[ { "uniprot_canonical_ac": "Q8VCK6-1", "uniprot_id": "FFAR2_MOUSE", "mass": 37124.0, "length": 330, "protein_name": "Free fatty acid receptor 2", "gene_name": "Ffar2", "organism": "Mouse", "refseq_name": "free fatty acid receptor 2", "refseq_ac": "NP_001161981", "gene_names_uniprotkb": "Ffar2; Gpr43; Lssig", "gene_names_refseq": "Ffar2; GPCR43; Gpr43", "protein_names_uniprotkb": "Free fatty acid receptor 2; G protein-coupled receptor 43; Leukocyte-specific STAT-induced GPCR", "protein_names_refseq": "G protein-coupled receptor 43; free fatty acid receptor 2; leukocyte-specific STAT-induced GPCR", "tax_id": 10090, "disease": "", "pathway": " (mmu:233079); (R-MMU-416476); (R-MMU-444209)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "12393494;12684041;16123168;18499755;19865172;19917676;20399779;21750661;22190648;23066016;23589301;23665276;30084848", "class_list": "", "function": "A potential role for GPR43 in regulating plasma lipid profiles and perhaps aspects of metabolic syndrome., [RefSeq, PubMed]; Acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43, but not through GPCR41., [RefSeq, PubMed]; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine (PubMed:22190648, PubMed:23589301). May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake (PubMed:20399779). Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes (PubMed:16123168, PubMed:23589301). In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines (PubMed:23665276). May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils (PubMed:19865172, PubMed:19917676). In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Induced by the activation of STAT3; might play pivotal role in differentiation and immune response of monocytes and granulocytes, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032722 positive regulation of chemokine production;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VCK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11088-1", "uniprot_id": "FILA_MOUSE", "mass": 35678.0, "length": 336, "protein_name": "Filaggrin", "gene_name": "Flg", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Flg", "gene_names_refseq": "", "protein_names_uniprotkb": "Filaggrin", "protein_names_refseq": "", "tax_id": 10090, "disease": "atopic dermatitis 2 (Disease Ontology:DOID:0110098)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "21750661;24751727;24832573;34428180;3680218;6174530", "class_list": "", "function": "Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990254 keratin filament binding;GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity;GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0001533 cornified envelope;GO:0036457 keratohyalin granule", "go_biological_process": "GO:0061436 establishment of skin barrier;GO:0008544 epidermis development;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P11088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20489-1", "uniprot_id": "FCERA_MOUSE", "mass": 28657.0, "length": 250, "protein_name": "High affinity immunoglobulin epsilon receptor subunit alpha", "gene_name": "Fcer1a", "organism": "Mouse", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit alpha precursor", "refseq_ac": "NP_034314", "gene_names_uniprotkb": "Fcer1a; Fce1a", "gene_names_refseq": "FcERI; Fce1a; Fcer1a; Fcr-5; fcepsilonri", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha", "protein_names_refseq": "fc-epsilon RI-alpha; high affinity immunoglobulin epsilon receptor subunit alpha precursor; high affinity immunoglobulin epsilon receptor subunit alpha; igE Fc receptor subunit alpha", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:14125); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "17728245;1839735;21750661;2527850;31219806;36210013", "class_list": "", "function": "High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QLR4", "ec_number_list": "", "go_molecular_function": "GO:0019767 IgE receptor activity;GO:0019863 IgE binding;GO:0019768 high-affinity IgE receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032752 positive regulation of interleukin-3 production;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0043306 positive regulation of mast cell degranulation;GO:0043406 positive regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20489-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q71KU9-1", "uniprot_id": "FGL1_MOUSE", "mass": 36439.0, "length": 314, "protein_name": "Fibrinogen-like protein 1", "gene_name": "Fgl1", "organism": "Mouse", "refseq_name": "fibrinogen-like protein 1 precursor", "refseq_ac": "NP_663569", "gene_names_uniprotkb": "Fgl1; Mfire1", "gene_names_refseq": "Fgl1; Mfire1", "protein_names_uniprotkb": "Fibrinogen-like protein 1; Fibrinogen-related protein 1; Liver fibrinogen-related protein-1; Mfire-1; Mfrep-1", "protein_names_refseq": "MFIRE-1; fibrinogen-like protein 1 precursor; fibrinogen-related protein 1; liver fibrinogen-related protein-1; mfrep-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234199)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12528893;21750661;23483972;26740625;30580966;34428180;36173010;37938970;38232308", "class_list": "", "function": "FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation., [RefSeq, PubMed]; Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade., [RefSeq, PubMed]; Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a ligand of LAG3. LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC25", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0008203 cholesterol metabolic process;GO:0060612 adipose tissue development;GO:0007596 blood coagulation;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q71KU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRA8-1", "uniprot_id": "EXOS5_MOUSE", "mass": 25194.0, "length": 235, "protein_name": "Exosome complex component RRP46", "gene_name": "Exosc5", "organism": "Mouse", "refseq_name": "exosome complex component RRP46", "refseq_ac": "NP_613052", "gene_names_uniprotkb": "Exosc5; D7Wsu180e; Rrp46", "gene_names_refseq": "D7Wsu180e; Exosc5", "protein_names_uniprotkb": "Exosome complex component RRP46; Exosome component 5; Ribosomal RNA-processing protein 46", "protein_names_refseq": "exosome complex component RRP46; exosome complex exonuclease RRP46; ribosomal RNA-processing protein 46", "tax_id": 10090, "disease": "", "pathway": " (mmu:27998); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "17242355;21183079;21750661", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1J2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000791 euchromatin", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006396 RNA processing;GO:0051607 defense response to virus;GO:0006402 mRNA catabolic process;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CRA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35622-1", "uniprot_id": "FGF15_MOUSE", "mass": 25236.0, "length": 218, "protein_name": "Fibroblast growth factor 15", "gene_name": "Fgf15", "organism": "Mouse", "refseq_name": "fibroblast growth factor 15 precursor", "refseq_ac": "NP_032029", "gene_names_uniprotkb": "Fgf15", "gene_names_refseq": "FGF19; Fgf15; Fgf8a", "protein_names_uniprotkb": "Fibroblast growth factor 15; FGF-15", "protein_names_refseq": "FGF-15; fibroblast growth factor 15 precursor; fibroblast growth factor 8a", "tax_id": 10090, "disease": "alcoholic hepatitis (Disease Ontology:DOID:12351)", "pathway": " (mmu:14170); (R-MMU-109704); (R-MMU-1257604); (R-MMU-1307965); (R-MMU-190322); (R-MMU-5654228); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 12, "publication_count": 4, "publication_id_list": "16213224;21750661;23747249;9310317", "class_list": "glycogene", "function": "Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0M0-1", "uniprot_id": "EXOS7_MOUSE", "mass": 31825.0, "length": 291, "protein_name": "Exosome complex exonuclease RRP42", "gene_name": "Exosc7", "organism": "Mouse", "refseq_name": "exosome complex exonuclease RRP42 isoform 1", "refseq_ac": "NP_001074657", "gene_names_uniprotkb": "Exosc7; Rrp42", "gene_names_refseq": "2610002K22Rik; Exosc7; mKIAA0116", "protein_names_uniprotkb": "Exosome complex exonuclease RRP42; Exosome component 7; Ribosomal RNA-processing protein 42", "protein_names_refseq": "exosome complex exonuclease RRP42 isoform 1; exosome complex exonuclease RRP42; ribosomal RNA-processing protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:66446); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;37507081", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBW5;Q9CT77", "ec_number_list": "", "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0000176 nuclear exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006396 RNA processing;GO:0016075 rRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D0M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZN0-1", "uniprot_id": "FBX15_MOUSE", "mass": 49486.0, "length": 433, "protein_name": "F-box only protein 15", "gene_name": "Fbxo15", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fbxo15; Fbx15", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box only protein 15", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:50764); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10531037;12665572;21750661", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A870-1", "uniprot_id": "FBF1_MOUSE", "mass": 130138.0, "length": 1173, "protein_name": "Fas-binding factor 1", "gene_name": "Fbf1", "organism": "Mouse", "refseq_name": "fas-binding factor 1 isoform 1", "refseq_ac": "NP_766159", "gene_names_uniprotkb": "Fbf1", "gene_names_refseq": "1110033G01Rik; 5930413D20; Fbf1; mKIAA1863", "protein_names_uniprotkb": "Fas-binding factor 1; FBF-1", "protein_names_refseq": "FBF-1; fas-binding factor 1 isoform 1; likely ortholog of H. sapiens Fas (TNFRSF6) binding factor 1 (FBF1)", "tax_id": 10090, "disease": "", "pathway": " (mmu:217335); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10978533;18838552;21750661;33561696;34348145;34428180", "class_list": "", "function": "FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue., [RefSeq, PubMed]; Fbf1 regulates mouse oocyte meiosis by influencing Plk1., [RefSeq, PubMed]; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis (By similarity)., [UniProtKB, UniProtKB]; Keratins and the keratin-binding protein Albatross are important for epithelial cell polarization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A871;B2RQ77;Q8BSP0;Q99MZ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0043297 apical junction assembly;GO:0060271 cilium assembly;GO:0090162 establishment of epithelial cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2A870-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64378-1", "uniprot_id": "FKBP5_MOUSE", "mass": 50966.0, "length": 456, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP5", "gene_name": "Fkbp5", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP5", "refseq_ac": "NP_034350", "gene_names_uniprotkb": "Fkbp5; Fkbp51", "gene_names_refseq": "D17Ertd592e; Dit1; FKBP-5; FKBP51; Fkbp5", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP5; 5.2.1.8; 51 kDa FK506-binding protein; 51 kDa FKBP; FK506-binding protein 5; FKBP-51; FKBP-5; PPIase FKBP5; Rotamase", "protein_names_refseq": "51 kDa FK506-binding protein; 51 kDa FKBP; PPIase FKBP5; peptidyl-prolyl cis-trans isomerase FKBP5; rotamase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); major depressive disorder (Disease Ontology:DOID:1470); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); cocaine abuse (Disease Ontology:DOID:809); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14229); (R-MMU-3371497); (R-MMU-8939211); (R-MMU-9909505)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11751894;21750661;21994940;38914303;7479941;7542743", "class_list": "", "function": "FKBP51 is involved in LPS-induced microglial activation via NF-kappaB signaling to mediate neuroinflammation., [RefSeq, PubMed]; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8;2.7.11.10;2.7.11.1;3.6.4.10;2.7.11.24;3.1.3.16;5.3.99.3", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031072 heat shock protein binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0097305 response to alcohol;GO:0009617 response to bacterium;GO:0042220 response to cocaine;GO:0006457 protein folding;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64378-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UPI1-1", "uniprot_id": "GAK1B_MOUSE", "mass": 58298.0, "length": 517, "protein_name": "Golgi-associated kinase 1B", "gene_name": "Gask1b", "organism": "Mouse", "refseq_name": "Golgi-associated kinase 1B", "refseq_ac": "NP_573450", "gene_names_uniprotkb": "Gask1b; Ened; Fam198b", "gene_names_refseq": "1110032E23Rik; 2210419I08Rik; Ened; Fam198b; Gask1b; GaskbB", "protein_names_uniprotkb": "Golgi-associated kinase 1B; Expressed in nerve and epithelium during development; Protein FAM198B", "protein_names_refseq": "Golgi-associated kinase 1B; expressed in nerve and epithelium during development; family with sequence similarity 198, member B; protein ENED; protein FAM198B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68659)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18956345;21750661", "class_list": "", "function": "Ened might be a novel target gene of the Fgfr signalling pathway during embryonic development, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B3VSA6;Q6PGJ9;Q8C781;Q9ET25", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UPI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGY7-1", "uniprot_id": "MIMS1_MOUSE", "mass": 31600.0, "length": 273, "protein_name": "Mitochondrial inner membrane scaffold 1", "gene_name": "Fam210a; Mims1", "organism": "Mouse", "refseq_name": "protein FAM210A", "refseq_ac": "NP_722489", "gene_names_uniprotkb": "Fam210a; Mims1; 4933403F05Rik; Fam210a", "gene_names_refseq": "4933403F05Rik; Fam210a; Mims1", "protein_names_uniprotkb": "Mitochondrial inner membrane scaffold 1; Protein FAM210A", "protein_names_refseq": "family with sequence similarity 210, member A; protein FAM210A; uncharacterized protein C18orf19 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:108654)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;29618611;31219806;31980842;33369227;37507081;37522353;37816711", "class_list": "", "function": "FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]; FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis., [RefSeq, PubMed]; Fam210a was expressed in muscle mitochondria and cytoplasm but not in bone. Nevertheless, in genetically modified mouse models, Fam210a strongly influenced the structure and strength of both muscle and bone., [RefSeq, PubMed]; MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling., [RefSeq, PubMed]; Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism (PubMed:29618611, PubMed:37522353). Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes (PubMed:37522353). Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis (PubMed:29618611, PubMed:31980842). In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing (PubMed:37816711). Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function (PubMed:37522353). In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors (PubMed:31980842)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXD0;Q8BNY5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BGY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIG9-1", "uniprot_id": "FBXL8_MOUSE", "mass": 41145.0, "length": 374, "protein_name": "F-box/LRR-repeat protein 8", "gene_name": "Fbxl8", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 8", "refseq_ac": "NP_056636", "gene_names_uniprotkb": "Fbxl8; Fbl8", "gene_names_refseq": "FBL8; Fbxl8", "protein_names_uniprotkb": "F-box/LRR-repeat protein 8; F-box and leucine-rich repeat protein 8; F-box protein FBL8", "protein_names_refseq": "F-box protein FBL8; F-box/LRR-repeat protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:50788); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10531037;21750661;34428180", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZN7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CIG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51880-1", "uniprot_id": "FABP7_MOUSE", "mass": 14893.0, "length": 132, "protein_name": "Fatty acid-binding protein, brain", "gene_name": "Fabp7", "organism": "Mouse", "refseq_name": "fatty acid-binding protein, brain", "refseq_ac": "NP_067247", "gene_names_uniprotkb": "Fabp7; Blbp", "gene_names_refseq": "B-FABP; BFABP; Blbp; Fabp7; MRG", "protein_names_uniprotkb": "Fatty acid-binding protein, brain; B-FABP; BLBP; Brain lipid-binding protein; Brain-type fatty acid-binding protein; Fatty acid-binding protein 7", "protein_names_refseq": "brain lipid-binding protein; brain-type fatty acid-binding protein; fatty acid-binding protein 7; fatty acid-binding protein, brain; mammary-derived growth inhibitor-related", "tax_id": 10090, "disease": "glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:12140); (R-MMU-163560)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;7956838;8161459;8722323", "class_list": "", "function": "B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJK4", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0043025 neuronal cell body;GO:0044297 cell body", "go_biological_process": "GO:0001964 startle response;GO:0060134 prepulse inhibition;GO:0015908 fatty acid transport;GO:0021846 cell proliferation in forebrain;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89106-1", "uniprot_id": "FHIT_MOUSE", "mass": 17235.0, "length": 150, "protein_name": "Bis(5'-adenosyl)-triphosphatase", "gene_name": "Fhit", "organism": "Mouse", "refseq_name": "bis(5'-adenosyl)-triphosphatase isoform 2", "refseq_ac": "NP_001295215", "gene_names_uniprotkb": "Fhit", "gene_names_refseq": "Fhit; Fra14A2", "protein_names_uniprotkb": "Bis(5'-adenosyl)-triphosphatase; 2.7.7.51; 3.6.1.29; 3.6.2.1; 3.9.1.-; AP3A hydrolase; AP3Aase; Adenosine 5'-monophosphoramidase FHIT; Adenylylsulfatase; Adenylylsulfate-ammonia adenylyltransferase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein", "protein_names_refseq": "AP3A hydrolase; AP3Aase; adenosine 5'-monophosphoramidase FHIT; adenylylsulfatase; adenylylsulfate-ammonia adenylyltransferase; bis(5'-adenosyl)-triphosphatase isoform 2; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad protein", "tax_id": 10090, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); squamous cell carcinoma (Disease Ontology:DOID:1749); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung non-small cell carcinoma (Disease Ontology:DOID:3908); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:14198)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10758156;11517343;14630947;21750661;24223161;24244712;26782170;27513973;9671749;9699672", "class_list": "", "function": "Fhit deficiency-induced global genome instability promotes mutation and clonal expansion Publication Status: Online-Only, [RefSeq, PubMed]; Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. Publication Status: Online-Only, [RefSeq, PubMed]; Fhit loss and subsequent thymidine kinase 1 inactivation, combined with selective pressures, leads to neoplasia-associated alterations in genes and gene expression patterns in vitro and in vivo, [RefSeq, PubMed]; Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient., [RefSeq, PubMed]; Possesses dinucleoside triphosphate hydrolase activity (By similarity). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as a tumor suppressor (PubMed:10758156, PubMed:11517343)., [UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6URW5;Q91VL1", "ec_number_list": "3.6.1.29;3.9.1.-;2.7.7.51;3.6.2.1;3.4.22.-;3.6.1.-;3.1.4.1;3.6.1.9", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0031625 ubiquitin protein ligase binding;GO:0016151 nickel cation binding;GO:0047710 bis(5'-adenosyl)-triphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0015964 diadenosine triphosphate catabolic process;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O89106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQK4-1", "uniprot_id": "EXOS3_MOUSE", "mass": 29546.0, "length": 274, "protein_name": "Exosome complex component RRP40", "gene_name": "Exosc3", "organism": "Mouse", "refseq_name": "exosome complex component RRP40 isoform 1", "refseq_ac": "NP_079789", "gene_names_uniprotkb": "Exosc3; Rrp40", "gene_names_refseq": "2310005D06Rik; Exosc3; Rrp40", "protein_names_uniprotkb": "Exosome complex component RRP40; 3.1.13.-; Exosome component 3; Ribosomal RNA-processing protein 40", "protein_names_refseq": "exosome complex component RRP40 isoform 1; exosome complex component RRP40; exosome complex exonuclease RRP40; ribosomal RNA-processing protein 40", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 1B (Disease Ontology:DOID:0060266); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:66362); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "21255825;21750661;22645316;23284067", "class_list": "", "function": "EXOSC3 mutations account for 30%-40% of patients with PCH1 with variability in survival and clinical severity that is correlated with the genotype., [RefSeq, PubMed]; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV81;Q9CVW2", "ec_number_list": "3.6.4.13;2.1.1.-;3.1.13.-;3.6.5.-;2.7.7.19;3.1.13.4;3.6.1.62;3.1.26.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0004527 exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006396 RNA processing;GO:0006402 mRNA catabolic process;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0045190 isotype switching;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TQK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55208-1", "uniprot_id": "FIGLA_MOUSE", "mass": 21529.0, "length": 194, "protein_name": "Factor in the germline alpha", "gene_name": "Figla", "organism": "Mouse", "refseq_name": "factor in the germline alpha", "refseq_ac": "NP_036143", "gene_names_uniprotkb": "Figla", "gene_names_refseq": "FIGalpha; Figla; bHLHc8", "protein_names_uniprotkb": "Factor in the germline alpha; FIGalpha; Transcription factor FIGa", "protein_names_refseq": "FIG alpha; factor in the germline alpha; transcription factor FIGa", "tax_id": 10090, "disease": "primary ovarian insufficiency 6 (Disease Ontology:DOID:0080863)", "pathway": " (mmu:26910)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11023867;32086523;33972571;9362457", "class_list": "", "function": "Figla promotes secondary follicle growth in mature mice. Publication Status: Online-Only, [RefSeq, PubMed]; Findings substantiate a major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis., [RefSeq, PubMed]; Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032502 developmental process;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O55208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11404-1", "uniprot_id": "FABPH_MOUSE", "mass": 14819.0, "length": 133, "protein_name": "Fatty acid-binding protein, heart", "gene_name": "Fabp3", "organism": "Mouse", "refseq_name": "fatty acid-binding protein, heart", "refseq_ac": "NP_034304", "gene_names_uniprotkb": "Fabp3; Fabph1", "gene_names_refseq": "Fabp3; Fabph-1; Fabph-4; Fabph1; Fabph4; H-FABP; Mdgi", "protein_names_uniprotkb": "Fatty acid-binding protein, heart; Fatty acid-binding protein 3; H-FABP; Heart-type fatty acid-binding protein; MDGI; Mammary-derived growth inhibitor", "protein_names_refseq": "fatty acid binding protein heart 1; fatty acid binding protein heart 4; fatty acid-binding protein 3; fatty acid-binding protein, heart; heart-type fatty acid-binding protein; mammary-derived growth inhibitor", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Down syndrome (Disease Ontology:DOID:14250); congenital heart disease (Disease Ontology:DOID:1682); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14077); (R-MMU-163560)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1429365;2740224;34428180;36288343;37507081;39008165;39012304;39927985;7926807", "class_list": "", "function": "Autophagy regulates age-related delayed jawbone regeneration and decreased osteoblast osteogenesis by degrading FABP3., [RefSeq, PubMed]; FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W23", "ec_number_list": "", "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0050543 icosatetraenoic acid binding;GO:0070538 oleic acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016528 sarcoplasm", "go_biological_process": "GO:2001245 regulation of phosphatidylcholine biosynthetic process;GO:0006631 fatty acid metabolic process;GO:0050873 brown fat cell differentiation;GO:0046320 regulation of fatty acid oxidation;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P11404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29699-1", "uniprot_id": "FETUA_MOUSE", "mass": 37326.0, "length": 345, "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "Ahsg", "organism": "Mouse", "refseq_name": "alpha-2-HS-glycoprotein isoform 1 precursor", "refseq_ac": "NP_038493", "gene_names_uniprotkb": "Ahsg; Fetua", "gene_names_refseq": "Ahsg", "protein_names_uniprotkb": "Alpha-2-HS-glycoprotein; Countertrypin; Fetuin-A", "protein_names_refseq": "alpha-2-HS-glycoprotein isoform 1 precursor; countertrypin; fetuin-A", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); alopecia-mental retardation syndrome 1 (Disease Ontology:DOID:0080628); gestational diabetes (Disease Ontology:DOID:11714); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11625); (R-MMU-114608); (R-MMU-381426); (R-MMU-6798695); (R-MMU-8957275)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;12648094;1373325;16113307;16944957;17242355;17330941;18630941;20571061;21183079;21750661;28011936;32069316;34428180;35984892;36288343;36647295;36716646;37507081;39627609;7688730;9395485", "class_list": "", "function": "(Microbial infection) Facilitates invasion of hepatocytes by Plasmodium berghei sporozoites., [UniProtKB, PubMed]; Exogenous fetuin-A protects against sepsis-induced myocardial injury by inhibiting oxidative stress and inflammation in mice., [RefSeq, PubMed]; FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway., [RefSeq, PubMed]; Probably involved in differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35634", "ec_number_list": "", "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006953 acute-phase response;GO:0045780 positive regulation of bone resorption;GO:0008584 male gonad development;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P29699-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39749-1", "uniprot_id": "FEN1_MOUSE", "mass": 42315.0, "length": 378, "protein_name": "Flap endonuclease 1", "gene_name": "Fen1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fen1; Fen-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Flap endonuclease 1; 3.1.-.-; FEN-1; Flap structure-specific endonuclease 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162)", "pathway": " (R-MMU-110362); (R-MMU-174437); (R-MMU-5651801); (R-MMU-5685939); (R-MMU-69166)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "23806337;25428506;30084848;34428180;7926735", "class_list": "", "function": "Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.-;2.4.2.30;3.2.1.143;2.7.7.102;3.1.11.2;3.1.21.-;2.7.7.7;3.1.-.-;3.1.11.-;3.6.-.-;4.2.99.18;4.2.99.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0004527 exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0007613 memory;GO:0006284 base-excision repair;GO:0006260 DNA replication;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P39749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55050-1", "uniprot_id": "FABPI_MOUSE", "mass": 15126.0, "length": 132, "protein_name": "Fatty acid-binding protein, intestinal", "gene_name": "Fabp2", "organism": "Mouse", "refseq_name": "fatty acid-binding protein, intestinal", "refseq_ac": "NP_032006", "gene_names_uniprotkb": "Fabp2; Fabpi", "gene_names_refseq": "Fabp2; Fabpi; I-FABP", "protein_names_uniprotkb": "Fatty acid-binding protein, intestinal; Fatty acid-binding protein 2; I-FABP; Intestinal-type fatty acid-binding protein", "protein_names_refseq": "fatty acid-binding protein, intestinal; intestinal fatty acid binding protein 2; intestinal-type fatty acid-binding protein", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); carotid stenosis (Disease Ontology:DOID:13001); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); coronary artery disease (Disease Ontology:DOID:3393); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14079); (R-MMU-163560)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11023988;1739433;17905650;38419457;9277406", "class_list": "", "function": "FABP2 is Involved in Intestinal alpha-Synuclein Pathologies., [RefSeq, PubMed]; FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor., [UniProtKB, PubMed]; Loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP, [RefSeq, PubMed]; The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within enterocytes, possibly to sense lipids as part of energy homeostasis. In humans polymorphisms are associated with increased fat oxidation and insulin resistance. In mice deficiency of this gene alters body weight in a gender-specific manner and causes hyperinsulinemia. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005902 microvillus", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0042594 response to starvation;GO:0032094 response to food;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55050-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61329-1", "uniprot_id": "FGF12_MOUSE", "mass": 27399.0, "length": 243, "protein_name": "Fibroblast growth factor 12", "gene_name": "Fgf12", "organism": "Mouse", "refseq_name": "fibroblast growth factor 12 isoform c", "refseq_ac": "NP_001263348", "gene_names_uniprotkb": "Fgf12; Fhf1", "gene_names_refseq": "B230343J05Rik; FGF-12; FHF-1; Fgf12; Fgf1a; Fhf1", "protein_names_uniprotkb": "Fibroblast growth factor 12; FGF-12; FHF-1; Fibroblast growth factor homologous factor 1; Myocyte-activating factor", "protein_names_refseq": "fibroblast growth factor 12 isoform c; fibroblast growth factor 1a; fibroblast growth factor homologous factor 1; myocyte-activating factor", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (mmu:14167)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;39142611;39234815;8790420;9232594", "class_list": "glycogene", "function": "FGF12 Positively Regulates Keratinocyte Proliferation by Stabilizing MDM2 and Inhibiting p53 Activity in Psoriasis., [RefSeq, PubMed]; Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation., [UniProtKB, UniProtKB]; Phenotyping of FGF12A[V52H] mutation in mouse implies a complex FGF12 network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35339;P70376;Q924B4;Q92912;Q93001", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0050905 neuromuscular process;GO:0007254 JNK cascade;GO:0007268 chemical synaptic transmission;GO:0010765 positive regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62932-1", "uniprot_id": "FBX40_MOUSE", "mass": 79951.0, "length": 710, "protein_name": "F-box only protein 40", "gene_name": "Fbxo40", "organism": "Mouse", "refseq_name": "F-box only protein 40", "refseq_ac": "NP_001032398", "gene_names_uniprotkb": "Fbxo40", "gene_names_refseq": "9830003A13Rik; Fbxo40; mKIAA1195", "protein_names_uniprotkb": "F-box only protein 40", "protein_names_refseq": "F-box only protein 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:207215); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17928169;22033112;36288343;37507081", "class_list": "", "function": "FBXO40 may function as a regulator involved in the postnatal myogenesis., [RefSeq, PubMed]; Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis., [UniProtKB, PubMed]; The Fbxo40 is muscle specific in expression and is upregulated during differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042692 muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62932-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70379-1", "uniprot_id": "FGF14_MOUSE", "mass": 27764.0, "length": 247, "protein_name": "Fibroblast growth factor 14", "gene_name": "Fgf14", "organism": "Mouse", "refseq_name": "fibroblast growth factor 14 isoform a", "refseq_ac": "NP_034331", "gene_names_uniprotkb": "Fgf14; Fhf4", "gene_names_refseq": "FGF-14; FHF-4; Fgf14; Fgf1b; Fhf4; Tg(tetO-MAPT*P301L)4510Kha; mFHF-4(1B)", "protein_names_uniprotkb": "Fibroblast growth factor 14; FGF-14; FHF-4; Fibroblast growth factor homologous factor 4", "protein_names_refseq": "fibroblast growth factor 14 isoform a; fibroblast growth factor 1b; fibroblast growth factor homologous factor 4", "tax_id": 10090, "disease": "spinocerebellar ataxia 27A (Disease Ontology:DOID:0050976); spinocerebellar ataxia 27B (Disease Ontology:DOID:0061137)", "pathway": " (mmu:14169)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10786625;21750661;26917740;8790420", "class_list": "glycogene", "function": "Probably involved in nervous system development and function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNZ6;Q8BST0;Q9JHL9", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0017080 sodium channel regulator activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0050905 neuromuscular process;GO:0007254 JNK cascade;GO:0007268 chemical synaptic transmission;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70379-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VDQ9-1", "uniprot_id": "FEZF1_MOUSE", "mass": 52006.0, "length": 475, "protein_name": "Fez family zinc finger protein 1", "gene_name": "Fezf1", "organism": "Mouse", "refseq_name": "fez family zinc finger protein 1", "refseq_ac": "NP_082738", "gene_names_uniprotkb": "Fezf1; Fez", "gene_names_refseq": "3110069A13Rik; Fezf1; Fez; Zfp312-like; fez-like", "protein_names_uniprotkb": "Fez family zinc finger protein 1", "protein_names_refseq": "fez family zinc finger protein 1", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 22 with or without anosmia (Disease Ontology:DOID:0090081)", "pathway": " (mmu:73191)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10781957;16540508;16971467;31219806", "class_list": "", "function": "Fez is involved in the axonal projection of olfactory sensory neurons., [RefSeq, PubMed]; These data indicate that Fez and Fezl repress the caudal diencephalon fate in the rostral diencephalon, and ZLI formation probably depends on Fez/Fezl-mediated formation of diencephalon subdivisions., [RefSeq, PubMed]; Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXM3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0VDQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24JP3-1", "uniprot_id": "F178B_MOUSE", "mass": 52581.0, "length": 464, "protein_name": "Protein FAM178B", "gene_name": "Fam178b", "organism": "Mouse", "refseq_name": "protein FAM178B isoform A", "refseq_ac": "NP_001119518", "gene_names_uniprotkb": "Fam178b", "gene_names_refseq": "1700024G10Rik; Fam178b; Gm990", "protein_names_uniprotkb": "Protein FAM178B", "protein_names_refseq": "protein FAM178B isoform A; protein FAM178B", "tax_id": 10090, "disease": "", "pathway": " (mmu:381337)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30084848;30779550", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URT9;Q80VJ7;Q9DA00", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q24JP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UY90-1", "uniprot_id": "GAK1A_MOUSE", "mass": 62298.0, "length": 562, "protein_name": "Golgi-associated kinase 1A", "gene_name": "Gask1a", "organism": "Mouse", "refseq_name": "Golgi-associated kinase 1A isoform 2 precursor", "refseq_ac": "NP_001186856", "gene_names_uniprotkb": "Gask1a; Fam198a", "gene_names_refseq": "C730027P07Rik; Fam198a; Gask1a", "protein_names_uniprotkb": "Golgi-associated kinase 1A; Protein FAM198A", "protein_names_refseq": "Golgi-associated kinase 1A isoform 2 precursor; family with sequence similarity 198, member A; protein FAM198A", "tax_id": 10090, "disease": "", "pathway": " (mmu:245050)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;30188967", "class_list": "", "function": "In mouse embryo fibroblasts (MEFs) obtained from cavin-1-/- or caveolin-1-/- mice, Fam198a precursor was retained in ER and no mature Fam198a could be formed in these cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYS0;Q3UTV8;Q8C7H6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005901 caveola", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UY90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q501J2-1", "uniprot_id": "ANKMT_MOUSE", "mass": 24740.0, "length": 229, "protein_name": "Adenine nucleotide translocase lysine N-methyltransferase", "gene_name": "Antkmt", "organism": "Mouse", "refseq_name": "adenine nucleotide translocase lysine N-methyltransferase isoform 1", "refseq_ac": "NP_663385", "gene_names_uniprotkb": "Antkmt; Fam173a", "gene_names_refseq": "ANT-KMT; Antkmt; Fam173a", "protein_names_uniprotkb": "Adenine nucleotide translocase lysine N-methyltransferase; 2.1.1.-; ANT-KMT", "protein_names_refseq": "adenine nucleotide translocase lysine N-methyltransferase isoform 1; adenine nucleotide translocase lysine N-methyltransferase; family with sequence similarity 173, member A; protein FAM173A; protein N-lysine methyltransferase FAM173A", "tax_id": 10090, "disease": "", "pathway": " (mmu:214917)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;35820727", "class_list": "", "function": "Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.372", "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0018023 peptidyl-lysine trimethylation;GO:1905706 regulation of mitochondrial ATP synthesis coupled proton transport;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q501J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q501P1-1", "uniprot_id": "FBLN7_MOUSE", "mass": 47927.0, "length": 440, "protein_name": "Fibulin-7", "gene_name": "Fbln7", "organism": "Mouse", "refseq_name": "fibulin-7 precursor", "refseq_ac": "NP_077199", "gene_names_uniprotkb": "Fbln7; Tm14", "gene_names_refseq": "1600015H20Rik; Fbln7; TM14", "protein_names_uniprotkb": "Fibulin-7; FIBL-7; Protein TM14", "protein_names_refseq": "FIBL-7; extracellular matrix protein TM14; fibulin-7 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:70370)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17699513;32297473;36278510;36370444", "class_list": "", "function": "A C-terminal fragment of adhesion protein fibulin-7 inhibits growth of murine breast tumor by regulating macrophage reprogramming., [RefSeq, PubMed]; An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation., [UniProtKB, PubMed]; Fibulin7 aggravates calcium oxalate-induced acute kidney injury by binding to calcium oxalate crystals., [RefSeq, PubMed]; TM14 is a cell adhesion molecule that interacts with extracellular matrix molecules in teeth and suggest that TM14 plays important roles in both the differentiation and maintenance of odontoblasts as well as in dentin formation., [RefSeq, PubMed]; The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAW5", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q501P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XJY6-1", "uniprot_id": "FANCB_MOUSE", "mass": 80088.0, "length": 703, "protein_name": "Fanconi anemia group B protein homolog", "gene_name": "Fancb", "organism": "Mouse", "refseq_name": "Fanconi anemia group B protein homolog isoform 1", "refseq_ac": "NP_001139553", "gene_names_uniprotkb": "Fancb", "gene_names_refseq": "Fancb", "protein_names_uniprotkb": "Fanconi anemia group B protein homolog; Protein FACB", "protein_names_refseq": "Fanconi anemia group B protein homolog isoform 1; fanconi anemia group B protein homolog", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group B (Disease Ontology:DOID:0111098); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520)", "pathway": " (mmu:237211); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;21913724;26123487;26658157;30084848;31219806;35596251", "class_list": "", "function": "DNA repair protein required for FANCD2 ubiquitination., [UniProtKB]; Data suggest that Fanconi anemia complementation group B protein Fancb(-/y) mouse model for studying the Fanconi anemia (FA) pathway not only in germ cell development but also in the maintenance of hematopoietic stem cell (HSC) function. Publication Status: Online-Only, [RefSeq, PubMed]; FANCB functions at critical stages of germ cell development and reveal a novel function of the FA pathway in the regulation of H3K9 methylation in the germline., [RefSeq, PubMed]; Fancb deficiency causes premature ovarian insufficiency in micedagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0000785 chromatin", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0060218 hematopoietic stem cell differentiation;GO:0071466 cellular response to xenobiotic stimulus;GO:0006950 response to stress;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5XJY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61559-1", "uniprot_id": "FCGRN_MOUSE", "mass": 40093.0, "length": 365, "protein_name": "IgG receptor FcRn large subunit p51", "gene_name": "Fcgrt", "organism": "Mouse", "refseq_name": "IgG receptor FcRn large subunit p51 isoform 1 precursor", "refseq_ac": "NP_034319", "gene_names_uniprotkb": "Fcgrt; Fcrn", "gene_names_refseq": "FcRn; Fcgrt", "protein_names_uniprotkb": "IgG receptor FcRn large subunit p51; FcRn; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor", "protein_names_refseq": "Fc receptor, IgG, alpha chain transporter; IgG receptor FcRn large subunit p51 isoform 1 precursor; igG Fc fragment receptor transporter alpha chain; igG receptor FcRn large subunit p51; neonatal Fc receptor; neonatal fragment crystallizable Fc receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14132)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26740625;32152506;34428180;7504013;7538537", "class_list": "", "function": "Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7504013). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUR0;Q9R2A5", "ec_number_list": "", "go_molecular_function": "GO:0030881 beta-2-microglobulin binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0010008 endosome membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61559-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZK7-1", "uniprot_id": "ATOSA_MOUSE", "mass": 119272.0, "length": 1075, "protein_name": "Atos homolog protein A", "gene_name": "Atosa", "organism": "Mouse", "refseq_name": "atos homolog protein A isoform 1", "refseq_ac": "NP_001106754", "gene_names_uniprotkb": "Atosa; Fam214a; Kiaa1370", "gene_names_refseq": "6330415I01Rik; Atosa; C130047D21Rik; Fam214a; Kiaa1370; mKIAA1370", "protein_names_uniprotkb": "Atos homolog protein A", "protein_names_refseq": "atos homolog protein A isoform 1; atos homolog protein A; family with sequence similarity 214, member A; protein FAM214A", "tax_id": 10090, "disease": "", "pathway": " (mmu:235493)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30084848;34428180;35319107", "class_list": "", "function": "Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PX00;Q8K0I6;Q8K266", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q69ZK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZT1-1", "uniprot_id": "FAN1_MOUSE", "mass": 112925.0, "length": 1020, "protein_name": "Fanconi-associated nuclease 1", "gene_name": "Fan1", "organism": "Mouse", "refseq_name": "fanconi-associated nuclease 1", "refseq_ac": "NP_808561", "gene_names_uniprotkb": "Fan1; Kiaa1018; Mtmr15", "gene_names_refseq": "6030441H18Rik; Fan1; Mtmr15; mFAN1", "protein_names_uniprotkb": "Fanconi-associated nuclease 1; 3.1.21.-; 3.1.4.1; FANCD2/FANCI-associated nuclease 1; Myotubularin-related protein 15; mFAN1", "protein_names_refseq": "coiled-coil domain-containing protein MTMR15; fanconi-associated nuclease 1; myotubularin-related protein 15", "tax_id": 10090, "disease": "karyomegalic interstitial nephritis (Disease Ontology:DOID:0060911); Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (mmu:330554); (R-MMU-6783310)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "24981866;32876667;34428180;34718701;35820727", "class_list": "", "function": "FAN1's protection against CGG repeat expansion requires its nuclease activity and is FANCD2-independent., [RefSeq, PubMed]; Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (PubMed:24981866). Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (By similarity). Also has endonuclease activity toward 5'-flaps (PubMed:24981866)., [UniProtKB, UniProtKB, PubMed]; Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14B88;Q8BVK2", "ec_number_list": "3.1.21.-;3.1.4.1;3.6.4.13;3.4.19.12;3.1.-.-;3.5.2.6;3.1.22.-;2.3.2.27", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0004528 phosphodiesterase I activity;GO:0008409 5'-3' exonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0045171 intercellular bridge", "go_biological_process": "GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q69ZT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A044-1", "uniprot_id": "EREP2_MOUSE", "mass": 54479.0, "length": 515, "protein_name": "Protein ENTREP2", "gene_name": "Entrep2", "organism": "Mouse", "refseq_name": "protein ENTREP2", "refseq_ac": "NP_898910", "gene_names_uniprotkb": "Entrep2; Fam189a1; Kiaa0574", "gene_names_refseq": "5730507A09Rik; Entrep2; Fam189a1", "protein_names_uniprotkb": "Protein ENTREP2; Endosomal transmembrane epsin interactor 2", "protein_names_refseq": "family with sequence similarity 189, member A1; protein ENTREP2; protein FAM189A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70638)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHP9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6A044-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9Q4-1", "uniprot_id": "FHOD1_MOUSE", "mass": 129600.0, "length": 1197, "protein_name": "FH1/FH2 domain-containing protein 1", "gene_name": "Fhod1", "organism": "Mouse", "refseq_name": "FH1/FH2 domain-containing protein 1", "refseq_ac": "NP_808367", "gene_names_uniprotkb": "Fhod1; Fhos1", "gene_names_refseq": "FHOS1; FHOS; Fhod1", "protein_names_uniprotkb": "FH1/FH2 domain-containing protein 1; FHOS; Formin homolog overexpressed in spleen 1; Formin homology 2 domain-containing protein 1", "protein_names_refseq": "FH1/FH2 domain-containing protein 1; formin homolog overexpressed in spleen 1; formin homology 2 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234686)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15966898;17242355;21183079;21605332;25428506;26495903;28528544;28708292;30084848;30779550;31008549;31219806;34428180;34887587;39627609;40885482", "class_list": "", "function": "FHOD1 is regulated by ROCK for cytoplasm actin assembly and spindle migration during mouse oocyte meiosis., [RefSeq, PubMed]; Fhod1 appears to be dispensable for normal development and function of the mouse heart, even if a marginal amount of Fhod1 is expressed in the heart., [RefSeq, PubMed]; Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets., [RefSeq, PubMed]; Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMK2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051496 positive regulation of stress fiber assembly;GO:0051492 regulation of stress fiber assembly;GO:0007097 nuclear migration", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6P9Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UG1-1", "uniprot_id": "FADS6_MOUSE", "mass": 38831.0, "length": 342, "protein_name": "Fatty acid desaturase 6", "gene_name": "Fads6", "organism": "Mouse", "refseq_name": "fatty acid desaturase 6", "refseq_ac": "NP_828874", "gene_names_uniprotkb": "Fads6", "gene_names_refseq": "Fads6", "protein_names_uniprotkb": "Fatty acid desaturase 6; 1.14.19.-", "protein_names_refseq": "fatty acid desaturase 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:328035)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12588793;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YA0;Q810B5", "ec_number_list": "", "go_molecular_function": "GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80UG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VF6-1", "uniprot_id": "F181B_MOUSE", "mass": 42437.0, "length": 417, "protein_name": "Protein FAM181B", "gene_name": "Fam181b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fam181b; MNCb-1231", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein FAM181B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:58238)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3URI7;Q9JJD9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80VF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG80-1", "uniprot_id": "FBX46_MOUSE", "mass": 65294.0, "length": 603, "protein_name": "F-box only protein 46", "gene_name": "Fbxo46", "organism": "Mouse", "refseq_name": "F-box only protein 46", "refseq_ac": "NP_780739", "gene_names_uniprotkb": "Fbxo46; Fbx46; Fbxo34l", "gene_names_refseq": "20D7-FC4; 4932704E22Rik; Fbxo34l; Fbxo46", "protein_names_uniprotkb": "F-box only protein 46; F-box only protein 34-like", "protein_names_refseq": "F-box only protein 46", "tax_id": 10090, "disease": "", "pathway": " (mmu:243867)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins. In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BG80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGE5-1", "uniprot_id": "FANCM_MOUSE", "mass": 226018.0, "length": 2021, "protein_name": "Fanconi anemia group M protein homolog", "gene_name": "Fancm", "organism": "Mouse", "refseq_name": "Fanconi anemia group M protein homolog isoform 1", "refseq_ac": "NP_849243", "gene_names_uniprotkb": "Fancm; Kiaa1596", "gene_names_refseq": "C730036B14Rik; D12Ertd364e; Fancm", "protein_names_uniprotkb": "Fanconi anemia group M protein homolog; 3.6.4.13; ATP-dependent RNA helicase FANCM; Protein FACM", "protein_names_refseq": "ATP-dependent RNA helicase FANCM; Fanconi anemia group M protein homolog isoform 1; fanconi anemia group M protein homolog", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); primary ovarian insufficiency 15 (Disease Ontology:DOID:0080872); spermatogenic failure 28 (Disease Ontology:DOID:0111916); Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (mmu:104806); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19561169;21750661;22872234;29895858;30022024;31219806;33882298;35984892", "class_list": "", "function": "DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; FANCM regulates repair pathway choice at stalled replication forks., [RefSeq, PubMed]; Fancm(Delta2/Delta2) mice also showed unique features atypical for Fanconi anemia mice, including underrepresentation of female Fancm(Delta2/Delta2) mice and decreased overall and tumor-free survival., [RefSeq, PubMed]; Suppression of Rad52 expression in combination with FANCM knockout drastically reduces cell and tumor growth, suggesting a synthetic lethality interaction between these two genes. Publication Status: Online-Only, [RefSeq, PubMed]; The loss-of-function FANCM pathogenic variants (PV) increased ICL sensitivity in lymphocytes of patients and Fancm(DeltaC/DeltaC) spermatogonia.neither bone marrow failure nor cancer/tumor was detected in all the patients or adult Fancm(DeltaC/DeltaC) mice. These findings revealed male infertility to be a novel phenotype of human patients with a biallelic FANCM PV. Erratum:[Genet Med. 2019 Jan;21(1):266. doi: 10.1038/s41436-018-0127-0. PMID: 30158692], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZF5;Q8BKB7;Q8BUA8", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;2.7.10.2;2.7.11.1;5.6.2.-;7.2.2.-;7.6.2.16;3.1.21.-;3.1.4.1;2.7.7.7;3.4.19.12;3.5.2.6;3.4.21.53;2.7.7.49;2.7.4.3;3.1.22.-;2.3.2.23", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000400 four-way junction DNA binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0071821 FANCM-MHF complex;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005634 nucleus", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0036297 interstrand cross-link repair;GO:0031297 replication fork processing;GO:1902527 positive regulation of protein monoubiquitination;GO:0045003 double-strand break repair via synthesis-dependent strand annealing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BGE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIX9-1", "uniprot_id": "FICD_MOUSE", "mass": 51754.0, "length": 458, "protein_name": "Protein adenylyltransferase FICD", "gene_name": "Ficd", "organism": "Mouse", "refseq_name": "protein adenylyltransferase FICD", "refseq_ac": "NP_001010825", "gene_names_uniprotkb": "Ficd; D5Ertd40e", "gene_names_refseq": "D5Ertd40e; Ficd; Hype", "protein_names_uniprotkb": "Protein adenylyltransferase FICD; 2.7.7.108; 3.1.4.-; AMPylator FICD; De-AMPylase FICD; FIC domain-containing protein", "protein_names_refseq": "AMPylator FICD; FIC domain-containing protein; adenosine monophosphate-protein transferase FICD; de-AMPylase FICD; huntingtin interacting protein E; huntingtin interactor protein E; protein adenylyltransferase FICD", "tax_id": 10090, "disease": "hereditary spastic paraplegia 92 (Disease Ontology:DOID:0070644); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:231630)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;31219806;34428180;35820727;35914137;38740171;39259589", "class_list": "", "function": "Fic-mediated AMPylation tempers the unfolded protein response during physiological stress., [RefSeq, PubMed]; FicD regulates adaptation to the unfolded protein response in the murine liver., [RefSeq, PubMed]; FicD sensitizes cellular response to glucose fluctuations in mouse embryonic fibroblasts., [RefSeq, PubMed]; Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (By similarity). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4QPF9;Q8BIC9;Q8BJ12", "ec_number_list": "3.1.4.-;2.7.7.108;2.7.7.-", "go_molecular_function": "GO:0044603 protein adenylylhydrolase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903894 regulation of IRE1-mediated unfolded protein response;GO:0044602 protein deadenylylation;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein;GO:0018117 protein adenylylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BIX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BK06-1", "uniprot_id": "FBX9_MOUSE", "mass": 50760.0, "length": 437, "protein_name": "F-box only protein 9", "gene_name": "Fbxo9", "organism": "Mouse", "refseq_name": "F-box only protein 9 isoform 2", "refseq_ac": "NP_001074959", "gene_names_uniprotkb": "Fbxo9; MNCb-2471", "gene_names_refseq": "9030401P18Rik; Fbxo9", "protein_names_uniprotkb": "F-box only protein 9", "protein_names_refseq": "F-box only protein 9 isoform 2; f-box only protein 9", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:71538); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17242355;20459822;21183079;21750661;23643813;27197753;32029586;38227647", "class_list": "", "function": "ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of Fbxo9 in neural crest progenitors down-regulated Neurog2 protein expression through ubiquitination and promoted the glial lineage at the expense of neuronal differentiation., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (By similarity). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (By similarity). Also regulates PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (PubMed:23643813, PubMed:27197753)., [UniProtKB, PubMed, PubMed, UniProtKB]; Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDY6;Q9D349;Q9JJC5", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BK06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BR21-1", "uniprot_id": "F180A_MOUSE", "mass": 19449.0, "length": 173, "protein_name": "Protein FAM180A", "gene_name": "Fam180a", "organism": "Mouse", "refseq_name": "protein FAM180A precursor", "refseq_ac": "NP_775551", "gene_names_uniprotkb": "Fam180a", "gene_names_refseq": "B230314O19; Fam180a", "protein_names_uniprotkb": "Protein FAM180A", "protein_names_refseq": "protein FAM180A precursor; protein FAM180A", "tax_id": 10090, "disease": "", "pathway": " (mmu:208164)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BR21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C790-1", "uniprot_id": "F221A_MOUSE", "mass": 33346.0, "length": 301, "protein_name": "Protein FAM221A", "gene_name": "Fam221a", "organism": "Mouse", "refseq_name": "protein FAM221A isoform 2", "refseq_ac": "NP_001165687", "gene_names_uniprotkb": "Fam221a; D330028D13Rik", "gene_names_refseq": "D330028D13Rik; Fam221a", "protein_names_uniprotkb": "Protein FAM221A", "protein_names_refseq": "protein FAM221A isoform 2; protein FAM221A; uncharacterized protein C7orf46 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:231946)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;32782141;32848054", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TML5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C790-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CAA5-1", "uniprot_id": "F163A_MOUSE", "mass": 17839.0, "length": 168, "protein_name": "Protein FAM163A", "gene_name": "Fam163a", "organism": "Mouse", "refseq_name": "protein FAM163A", "refseq_ac": "NP_808506", "gene_names_uniprotkb": "Fam163a", "gene_names_refseq": "A230106N23Rik; Fam163a", "protein_names_uniprotkb": "Protein FAM163A", "protein_names_refseq": "cebelin; protein FAM163A", "tax_id": 10090, "disease": "", "pathway": " (mmu:329274)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CAA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CAT8-1", "uniprot_id": "FBX48_MOUSE", "mass": 18762.0, "length": 161, "protein_name": "F-box only protein 48", "gene_name": "Fbxo48", "organism": "Mouse", "refseq_name": "F-box only protein 48", "refseq_ac": "NP_795956", "gene_names_uniprotkb": "Fbxo48; Fbx48", "gene_names_refseq": "A630050E13Rik; Fbxo48", "protein_names_uniprotkb": "F-box only protein 48; F-box protein 48", "protein_names_refseq": "F-box only protein 48; novel F-box domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:319701)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9J8", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CAT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDW1-1", "uniprot_id": "F228A_MOUSE", "mass": 34457.0, "length": 299, "protein_name": "Protein FAM228A", "gene_name": "Fam228a", "organism": "Mouse", "refseq_name": "protein FAM228A", "refseq_ac": "NP_083383", "gene_names_uniprotkb": "Fam228a", "gene_names_refseq": "4930417G10Rik; Fam228a", "protein_names_uniprotkb": "Protein FAM228A", "protein_names_refseq": "UPF0638 protein C2orf84 homolog; protein FAM228A", "tax_id": 10090, "disease": "", "pathway": " (mmu:74855)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5M5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CDW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEK7-1", "uniprot_id": "FATE1_MOUSE", "mass": 11726.0, "length": 99, "protein_name": "Fetal and adult testis-expressed transcript protein homolog", "gene_name": "Fate1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fate1; Fate", "gene_names_refseq": "", "protein_names_uniprotkb": "Fetal and adult testis-expressed transcript protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BM4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CEK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3B1-1", "uniprot_id": "FBSP1_MOUSE", "mass": 30605.0, "length": 286, "protein_name": "F-box/SPRY domain-containing protein 1", "gene_name": "Fbxo45", "organism": "Mouse", "refseq_name": "F-box/SPRY domain-containing protein 1", "refseq_ac": "NP_775615", "gene_names_uniprotkb": "Fbxo45", "gene_names_refseq": "2610017J04Rik; Fbxo45", "protein_names_uniprotkb": "F-box/SPRY domain-containing protein 1; F-box only protein 45; mFbxo45", "protein_names_refseq": "F-box only protein 45; F-box/SPRY domain-containing protein 1; mFbxo45", "tax_id": 10090, "disease": "", "pathway": " (mmu:268882)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "19398581;19996097;25428506;25605945;30084848;30779550;32341084;34428180;34779401;35820727;36127399;36853700;37828378", "class_list": "", "function": "Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but plays also an important role in assembly of the complex (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (PubMed:32341084). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome. Acts also by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation. Induces subsequently an increase in mitotic slippage and prevents mitotic cell death. In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Data suggest that Fbxo45 plays an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse., [RefSeq, PubMed]; Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation. Publication Status: Online-Only, [RefSeq, PubMed]; Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development. Publication Status: Online-Only, [RefSeq, PubMed]; Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation., [RefSeq, PubMed]; In vivo analysis of FBXO45-mediated fibrosis and liver tumorigenesis in a chemically induced mouse model of hepatocellular carcinoma., [RefSeq, PubMed]; Results suggest that Fbxo45 forms a novel Fbxo45-PAM ubiquitin ligase complex that plays an important role in neural development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M7B1", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060384 innervation;GO:0021799 cerebral cortex radially oriented cell migration;GO:0001764 neuron migration;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K3B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBV4-2", "uniprot_id": "FBXW7_MOUSE", "mass": 79848.0, "length": 710, "protein_name": "F-box/WD repeat-containing protein 7", "gene_name": "Fbxw7", "organism": "Mouse", "refseq_name": "F-box/WD repeat-containing protein 7 isoform 2", "refseq_ac": "NP_536353", "gene_names_uniprotkb": "Fbxw7; Fbw7; Fbwd6; Fbxw6", "gene_names_refseq": "1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; Fbxw7; SEL-10", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 7; F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; SEL-10", "protein_names_refseq": "F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7 isoform 2; F-box/WD repeat-containing protein 7; f-box only protein 30", "tax_id": 10090, "disease": "developmental delay, hypotonia, and impaired language (Disease Ontology:DOID:0070420)", "pathway": " (mmu:50754); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11425854;11461910;11735228;21953459;22748924;27238018;29149593;31219806", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459, PubMed:22748924). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:22748924). Mediates ubiquitination and subsequent degradation of CCNE1 and MYC (PubMed:22748924). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, MLST8, RICTOR and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (By similarity). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RRI5;D3YUA5;Q8CCS5;Q8VHP4", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010992 ubiquitin recycling;GO:0001570 vasculogenesis;GO:0006281 DNA repair;GO:0007219 Notch signaling pathway;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VBV4-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCM7-1", "uniprot_id": "FIBG_MOUSE", "mass": 49391.0, "length": 436, "protein_name": "Fibrinogen gamma chain", "gene_name": "Fgg", "organism": "Mouse", "refseq_name": "fibrinogen gamma chain isoform 1 precursor", "refseq_ac": "NP_598623", "gene_names_uniprotkb": "Fgg", "gene_names_refseq": "3010002H13Rik; Fgg", "protein_names_uniprotkb": "Fibrinogen gamma chain", "protein_names_refseq": "fibrinogen gamma chain isoform 1 precursor; fibrinogen, gamma polypeptide", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); brain small vessel disease (Disease Ontology:DOID:0112313); congenital afibrinogenemia (Disease Ontology:DOID:2236); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); multiple myeloma (Disease Ontology:DOID:9538); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:99571); (R-MMU-114608); (R-MMU-216083); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-381426); (R-MMU-5674135); (R-MMU-5686938); (R-MMU-8957275); (R-MMU-9769733)", "pathway_count": 11, "publication_count": 5, "publication_id_list": "19332769;23386199;26495903;34428180;40684658", "class_list": "", "function": "This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]., [RefSeq]; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8WUR3;Q91ZP0", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005198 structural molecule activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045202 synapse", "go_biological_process": "GO:0045087 innate immune response;GO:0051592 response to calcium ion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007160 cell-matrix adhesion;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VCM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Y47-1", "uniprot_id": "FA11_MOUSE", "mass": 69789.0, "length": 624, "protein_name": "Coagulation factor XI", "gene_name": "F11", "organism": "Mouse", "refseq_name": "coagulation factor XI isoform 1 preproprotein", "refseq_ac": "NP_082342", "gene_names_uniprotkb": "F11", "gene_names_refseq": "1600027G01Rik; Cf11; F11; FXI; PTA", "protein_names_uniprotkb": "Coagulation factor XI; 3.4.21.27; FXI; PTA; Plasma thromboplastin antecedent", "protein_names_refseq": "coagulation factor XI isoform 1 preproprotein; plasma thromboplastin antecedent", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); factor XI deficiency (Disease Ontology:DOID:2229); Noonan syndrome (Disease Ontology:DOID:3490)", "pathway": " (mmu:109821); (R-MMU-9769739); (R-MMU-9769743); (R-MMU-9935598)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11841337;30084848;31125187;34428180;36724509;9242536", "class_list": "", "function": "A non-circulating pool of factor XI associated with glycosaminoglycans in mice., [RefSeq, PubMed]; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX., [UniProtKB, UniProtKB]; Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development Review article, [RefSeq, PubMed]; This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]., [RefSeq]; Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAT3", "ec_number_list": "3.4.21.22;3.4.21.5;3.4.21.69;3.4.21.38;3.4.21.27", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity;GO:0070009 serine-type aminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0031639 plasminogen activation;GO:0030193 regulation of blood coagulation;GO:0051919 positive regulation of fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91Y47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920A9-1", "uniprot_id": "FCRLA_MOUSE", "mass": 38348.0, "length": 352, "protein_name": "Fc receptor-like A", "gene_name": "Fcrla", "organism": "Mouse", "refseq_name": "Fc receptor-like A isoform 1 precursor", "refseq_ac": "NP_001153687", "gene_names_uniprotkb": "Fcrla; Fcrl1; Fcrlm1; Fcrl; Fcrx; Freb", "gene_names_refseq": "FCRL1; FCRL; FREB; Fcrla; Fcrlm1; Fcrx; Freb1; mFREB; mFcrX", "protein_names_uniprotkb": "Fc receptor-like A; Fc receptor homolog expressed in B-cells; Fc receptor-like and mucin-like protein 1; Fc receptor-like protein; Fc receptor-related protein X; FcRX", "protein_names_refseq": "Fc receptor related X; Fc receptor related protein X; Fc receptor-like A isoform 1 precursor; Fc receptor-like mucin-like 1; fc receptor homolog expressed in B-cells; fc receptor-like and mucin-like protein 1; fc receptor-like protein; fc receptor-related protein X", "tax_id": 10090, "disease": "", "pathway": " (mmu:98752)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11754007;11891275;12202404;20668221;21750661;22078318;26495903;28011936", "class_list": "", "function": "FcRLA protein is expressed exclusively in all mouse B cells, where it plays a role in immunoglobulin assembly that can be compensated for by other proteins., [RefSeq, PubMed]; High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion., [RefSeq, PubMed]; May be implicated in B-cell differentiation and lymphomagenesis., [UniProtKB]; May function as a secreted or intracellular protein in normal and neoplastic B cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9Q2;Q8K3U9;Q8VHP5", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0030154 cell differentiation;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q920A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920L1-1", "uniprot_id": "FADS1_MOUSE", "mass": 52323.0, "length": 447, "protein_name": "Acyl-CoA (8-3)-desaturase", "gene_name": "Fads1", "organism": "Mouse", "refseq_name": "acyl-CoA (8-3)-desaturase", "refseq_ac": "NP_666206", "gene_names_uniprotkb": "Fads1", "gene_names_refseq": "0710001O03Rik; A930006B21Rik; DSD; Fads1", "protein_names_uniprotkb": "Acyl-CoA (8-3)-desaturase; 1.14.19.44; D5D; Delta(5) desaturase; Delta(5) fatty acid desaturase; Delta-5 desaturase; Fatty acid desaturase 1", "protein_names_refseq": "D5D; acyl-CoA (8-3)-desaturase; delta(5) desaturase; delta(5) fatty acid desaturase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:76267); (R-MMU-2046105); (R-MMU-2046106)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11792729;16846730;18483285;21750661;22534642;25428506;34428180;37453647;38682200;38926633", "class_list": "", "function": "Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (Probable). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (PubMed:22534642). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity)., [UniProtKB, PubMed, UniProtKB]; FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer., [RefSeq, PubMed]; N-3 fatty acid desaturase may have a role in colitis-associated colon cancer in mice, [RefSeq, PubMed]; Support a significant role for reverse Delta5-desaturase as a natural antisense regulator of Delta5-desaturase, [RefSeq, PubMed]; Targeted Knockdown of Hepatic Delta-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE[-/-] Mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U494;Q8BZX7;Q8R0G8;Q8VC07", "ec_number_list": "1.14.19.44", "go_molecular_function": "GO:0045485 omega-6 fatty acid desaturase activity;GO:0016491 oxidoreductase activity;GO:0016213 acyl-CoA 6-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0062076 acyl-CoA (8-3)-desaturase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0009267 cellular response to starvation;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q920L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Z4-1", "uniprot_id": "FER3L_MOUSE", "mass": 19463.0, "length": 168, "protein_name": "Fer3-like protein", "gene_name": "Ferd3l", "organism": "Mouse", "refseq_name": "fer3-like protein", "refseq_ac": "NP_277057", "gene_names_uniprotkb": "Ferd3l; Nato; Ntwist", "gene_names_refseq": "Ferd3l; Mnato3; N-twist; Nato3; Nato; Ntwist; Ptfb; bHLHa31; fer3", "protein_names_uniprotkb": "Fer3-like protein; Basic helix-loop-helix protein N-twist; Nephew of atonal 3; Neuronal twist", "protein_names_refseq": "Fer3-like; basic helix-loop-helix protein N-twist; fer3-like protein; nephew of atonal 3; neuronal twist; pancreas-specific transcription factor b", "tax_id": 10090, "disease": "", "pathway": " (mmu:114712)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11472856;12217327;20460368;24401371", "class_list": "", "function": "In the developing mesencephalon, loss of Nato3 did not affect floor plate (FP) differentiation, but led to loss of neurogenic activity in the medial subpopulation of mesFP cells by suppressing proneural gene expression and inducing cell cycle arrest, [RefSeq, PubMed]; Nato3 induces ectopic Foxa2-positive cells and indirectly downregulates Nkx2.2 expression., [RefSeq, PubMed]; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q923Z4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQS3-1", "uniprot_id": "FIBIN_MOUSE", "mass": 24760.0, "length": 217, "protein_name": "Fin bud initiation factor homolog", "gene_name": "Fibin", "organism": "Mouse", "refseq_name": "fin bud initiation factor homolog precursor", "refseq_ac": "NP_080547", "gene_names_uniprotkb": "Fibin", "gene_names_refseq": "1110018M03Rik; Fibin", "protein_names_uniprotkb": "Fin bud initiation factor homolog", "protein_names_refseq": "fin bud initiation factor homolog precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:67606)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17196583;21615908;34428180", "class_list": "", "function": "Fibin is expressed in cerebellum, skeletal muscle and many other embryonic and adult mouse tissues suggesting not only a role during embryonic development but also in adult functions Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX19-1", "uniprot_id": "F162B_MOUSE", "mass": 17686.0, "length": 157, "protein_name": "Protein FAM162B", "gene_name": "Fam162b", "organism": "Mouse", "refseq_name": "protein FAM162B", "refseq_ac": "NP_084170", "gene_names_uniprotkb": "Fam162b", "gene_names_refseq": "9430073N08Rik; Fam162b", "protein_names_uniprotkb": "Protein FAM162B", "protein_names_refseq": "protein FAM162B", "tax_id": 10090, "disease": "", "pathway": " (mmu:77296)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CX19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3R5-1", "uniprot_id": "F187A_MOUSE", "mass": 47878.0, "length": 417, "protein_name": "Ig-like V-type domain-containing protein FAM187A", "gene_name": "Fam187a", "organism": "Mouse", "refseq_name": "Ig-like V-type domain-containing protein FAM187A precursor", "refseq_ac": "NP_080042", "gene_names_uniprotkb": "Fam187a", "gene_names_refseq": "4933439F11Rik; Fam187a", "protein_names_uniprotkb": "Ig-like V-type domain-containing protein FAM187A", "protein_names_refseq": "Ig-like V-type domain-containing protein FAM187A precursor; ig-like V-type domain-containing protein ENSP00000329499 homolog; ig-like V-type domain-containing protein FAM187A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66784)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3Y8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D3R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4K4-1", "uniprot_id": "FACOS_MOUSE", "mass": 20228.0, "length": 178, "protein_name": "FANCD2 opposite strand protein", "gene_name": "Fancd2os", "organism": "Mouse", "refseq_name": "FANCD2 opposite strand protein", "refseq_ac": "NP_081909", "gene_names_uniprotkb": "Fancd2os", "gene_names_refseq": "4931417G12Rik; Fancd2os", "protein_names_uniprotkb": "FANCD2 opposite strand protein; Fanconi anemia group D2 protein opposite strand transcript protein", "protein_names_refseq": "FANCD2 opposite strand protein; Fanconi anemia group D2 protein opposite strand transcript protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70979)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35798552", "class_list": "", "function": "Reduces testosterone levels by inhibiting steroidogenic enzymes and by promoting apoptosis in Leydig cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J1W5;Q80XT0;Q80Y40", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:2000225 negative regulation of testosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4K5-1", "uniprot_id": "CMI2A_MOUSE", "mass": 36613.0, "length": 319, "protein_name": "Ciliary microtubule inner protein 2A", "gene_name": "Cimip2a", "organism": "Mouse", "refseq_name": "ciliary microtubule inner protein 2A isoform a", "refseq_ac": "NP_080900", "gene_names_uniprotkb": "Cimip2a; Fam166a", "gene_names_refseq": "4931415M17; Cimip2a; Fam166a", "protein_names_uniprotkb": "Ciliary microtubule inner protein 2A", "protein_names_refseq": "4931415M17 mRNA; ciliary microtubule inner protein 2A isoform a; family with sequence similarity 166, member A; protein FAM166A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68222)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "37295417;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme (PubMed:37295417, PubMed:37989994). Binds to the intra-tubulin interfaces (PubMed:37295417)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0036064 ciliary basal body;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D4K5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7I8-1", "uniprot_id": "FA83D_MOUSE", "mass": 64324.0, "length": 585, "protein_name": "Protein FAM83D", "gene_name": "Fam83d", "organism": "Mouse", "refseq_name": "protein FAM83D isoform 1", "refseq_ac": "NP_082251", "gene_names_uniprotkb": "Fam83d", "gene_names_refseq": "2310007D09Rik; Fam83d; Sack1d", "protein_names_uniprotkb": "Protein FAM83D", "protein_names_refseq": "family with sequence similarity 83, member D; protein FAM83D isoform 1; protein FAM83D", "tax_id": 10090, "disease": "", "pathway": " (mmu:71878); (R-MMU-177929)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "31219806;31338967", "class_list": "", "function": "Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (By similarity). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (By similarity). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AC91;Q3TXE0;Q6P396;Q8BYC0", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D7I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKV7-1", "uniprot_id": "EXTL1_MOUSE", "mass": 74079.0, "length": 669, "protein_name": "Exostosin-like 1", "gene_name": "Extl1", "organism": "Mouse", "refseq_name": "exostosin-like 1 isoform 1", "refseq_ac": "NP_062524", "gene_names_uniprotkb": "Extl1", "gene_names_refseq": "D430033M16Rik; Extl1", "protein_names_uniprotkb": "Exostosin-like 1; 2.4.1.224; Exostosin-L; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostosis-like protein", "protein_names_refseq": "Exostosin-like 1 (Exostosin-L) (Multiple exostosis-like protein); exostoses (multiple)-like 1; exostosin-L; exostosin-like 1 isoform 1; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; multiple exostoses-like 1; multiple exostosis-like protein", "tax_id": 10090, "disease": "hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (mmu:56219)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10878610;33300544", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity). Appears to lack GlcNAcT I and GlcAT-II activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 56, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKA3", "ec_number_list": "2.4.1.224", "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JKV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70433-1", "uniprot_id": "FHL2_MOUSE", "mass": 32073.0, "length": 279, "protein_name": "Four and a half LIM domains protein 2", "gene_name": "Fhl2", "organism": "Mouse", "refseq_name": "four and a half LIM domains protein 2", "refseq_ac": "NP_001276462", "gene_names_uniprotkb": "Fhl2", "gene_names_refseq": "FHL-2; Fhl2; SLIM-3; SLIM3", "protein_names_uniprotkb": "Four and a half LIM domains protein 2; FHL-2; SLIM-3; Skeletal muscle LIM-protein 3", "protein_names_refseq": "four and a half LIM domains protein 2; skeletal muscle LIM-protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:14200)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10049693;10906474;20013826;21540332;21750661;22851699;37507081;37834391;38569934;38814462", "class_list": "", "function": "Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:22851699)., [UniProtKB, UniProtKB, PubMed]; Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere., [RefSeq, PubMed]; Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97448", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0008134 transcription factor binding;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030018 Z disc;GO:0031430 M band", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70433-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02772-1", "uniprot_id": "FETA_MOUSE", "mass": 67337.0, "length": 605, "protein_name": "Alpha-fetoprotein", "gene_name": "Afp", "organism": "Mouse", "refseq_name": "alpha-fetoprotein precursor", "refseq_ac": "NP_031449", "gene_names_uniprotkb": "Afp", "gene_names_refseq": "Afp", "protein_names_uniprotkb": "Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin", "protein_names_refseq": "alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein precursor; alpha-foetoprotein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); endometrial cancer (Disease Ontology:DOID:1380); hepatitis C (Disease Ontology:DOID:1883); endodermal sinus tumor (Disease Ontology:DOID:1911); hepatitis (Disease Ontology:DOID:2237); teratocarcinoma (Disease Ontology:DOID:3305); embryonal carcinoma (Disease Ontology:DOID:3308); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:11576); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;2452956;6161929;6164927;6172714", "class_list": "glycogene", "function": "Binds estrogens, fatty acids and metals., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJD0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006955 immune response;GO:0006915 apoptotic process;GO:0031667 response to nutrient levels;GO:0042448 progesterone metabolic process;GO:0048872 homeostasis of number of cells", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02772-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59648-1", "uniprot_id": "FXYD7_MOUSE", "mass": 8487.0, "length": 80, "protein_name": "FXYD domain-containing ion transport regulator 7", "gene_name": "Fxyd7", "organism": "Mouse", "refseq_name": "FXYD domain-containing ion transport regulator 7", "refseq_ac": "NP_071290", "gene_names_uniprotkb": "Fxyd7", "gene_names_refseq": "1110035I01Rik; Fxyd7", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 7", "protein_names_refseq": "FXYD domain-containing ion transport regulator 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:57780); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10950925;12093728;15133029;16269407;21750661", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:12093728, PubMed:15133029, PubMed:16269407). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (PubMed:12093728, PubMed:15133029). Increases the apparent affinity for intracellular Na(+) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Expressed in Xenopus oocytes, mouse FXYD7 can interact with Na,K-ATPase alpha 1-beta 1, alpha 2-beta 1 and alpha 3-beta 1 but not with alpha-beta 2 isozymes whereas, in brain, it is only associated with alpha 1-beta isozymes., [RefSeq, PubMed]; FXYD7 is a new member of proteins with a regulated ER export and has a particular regulatory function in brain, [RefSeq, PubMed]; This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTD2", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P59648-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35550-1", "uniprot_id": "FBRL_MOUSE", "mass": 34307.0, "length": 327, "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "Fbl", "organism": "Mouse", "refseq_name": "rRNA 2'-O-methyltransferase fibrillarin isoform 1", "refseq_ac": "NP_032017", "gene_names_uniprotkb": "Fbl", "gene_names_refseq": "FIB; FLRN; Fbl; RNU3IP1", "protein_names_uniprotkb": "rRNA 2'-O-methyltransferase fibrillarin; 2.1.1.-; Histone-glutamine methyltransferase; Nucleolar protein 1; U6 snRNA 2'-O-methyltransferase fibrillarin", "protein_names_refseq": "U6 snRNA 2'-O-methyltransferase fibrillarin; histone-glutamine methyltransferase; nucleolar protein 1; rRNA 2'-O-methyltransferase fibrillarin isoform 1; rRNA 2'-O-methyltransferase fibrillarin", "tax_id": 10090, "disease": "", "pathway": " (mmu:14113); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;28135057;30283081;32017896;33300544;37453647;8218401", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:32017896). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017896). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017896). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L58", "ec_number_list": "2.1.1.-;3.1.13.-;3.6.4.13", "go_molecular_function": "GO:0003723 RNA binding;GO:0051117 ATPase binding;GO:0001094 TFIID-class transcription factor complex binding;GO:0008649 rRNA methyltransferase activity;GO:1990259 histone H2AQ104 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0005694 chromosome", "go_biological_process": "GO:0031167 rRNA methylation;GO:0016074 sno(s)RNA metabolic process;GO:0048254 snoRNA localization;GO:0000494 box C/D sno(s)RNA 3'-end processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35550-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11403-1", "uniprot_id": "FGF4_MOUSE", "mass": 21919.0, "length": 202, "protein_name": "Fibroblast growth factor 4", "gene_name": "Fgf4", "organism": "Mouse", "refseq_name": "fibroblast growth factor 4 precursor", "refseq_ac": "NP_034332", "gene_names_uniprotkb": "Fgf4; Fgf-4; Kfgf", "gene_names_refseq": "Fgf-4; Fgf4; Fgf7a; Fgfk; HBGF-4; Hst1; Hstf-1; KS3; hst-1; hst; kFGF", "protein_names_uniprotkb": "Fibroblast growth factor 4; FGF-4; HBGF-4; Heparin-binding growth factor 4; K-fibroblast growth factor", "protein_names_refseq": "K-fibroblast growth factor; fibroblast growth factor 4 precursor; fibroblast growth factor 7a; heparin-binding growth factor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:14175); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190372); (R-MMU-190373); (R-MMU-190375); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5658623); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 31, "publication_count": 4, "publication_id_list": "21750661;2318343;2740210;8898217", "class_list": "glycogene", "function": "Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (PubMed:8898217)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P15657;Q542N0", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11403-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53798-1", "uniprot_id": "FDFT_MOUSE", "mass": 48154.0, "length": 416, "protein_name": "Squalene synthase", "gene_name": "Fdft1", "organism": "Mouse", "refseq_name": "squalene synthase", "refseq_ac": "NP_034321", "gene_names_uniprotkb": "Fdft1; Erg9", "gene_names_refseq": "Fdft1; SQS; SS", "protein_names_uniprotkb": "Squalene synthase; 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; SQS; SS", "protein_names_refseq": "FPP:FPP farnesyltransferase; farnesyl-diphosphate farnesyltransferase; squalene synthase", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:14137); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10521476;20173027;21750661;22872234;25428506;25428507;25605945;30084848;30779550;31219806;34203471;34428180;37828378;7999794", "class_list": "", "function": "Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene (PubMed:10521476). Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPF5", "ec_number_list": "2.5.1.21", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051996 squalene synthase [NAD(P)H] activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol;GO:0008299 isoprenoid biosynthetic process;GO:0045338 farnesyl diphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A6H3-1", "uniprot_id": "FBX47_MOUSE", "mass": 51374.0, "length": 451, "protein_name": "F-box only protein 47", "gene_name": "Fbxo47", "organism": "Mouse", "refseq_name": "F-box only protein 47 isoform 1", "refseq_ac": "NP_001074904", "gene_names_uniprotkb": "Fbxo47", "gene_names_refseq": "2900052P03Rik; Fbxo47; Gm1562", "protein_names_uniprotkb": "F-box only protein 47", "protein_names_refseq": "F-box only protein 47 isoform 1; F-box only protein 47", "tax_id": 10090, "disease": "", "pathway": " (mmu:72973)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31724724", "class_list": "", "function": "Knockout of Fbxo47 in mice leads to infertility in males. The Fbxo47 deficient spermatocytes are unable to form a complete synaptonemal complex., [RefSeq, PubMed]; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RY07", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A6H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A9Q0-1", "uniprot_id": "FND10_MOUSE", "mass": 24417.0, "length": 223, "protein_name": "Fibronectin type III domain-containing protein 10", "gene_name": "Fndc10", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 10 precursor", "refseq_ac": "NP_848814", "gene_names_uniprotkb": "Fndc10", "gene_names_refseq": "B930041F14Rik; Fndc10; MNCb-3966", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 10", "protein_names_refseq": "fibronectin type III domain-containing protein 10 precursor; fibronectin type III domain-containing protein 10; fibronectin type-III domain-containing transmembrane protein C1orf233 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:230991)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXK6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2A9Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJL3-1", "uniprot_id": "FGGY_MOUSE", "mass": 60336.0, "length": 552, "protein_name": "FGGY carbohydrate kinase domain-containing protein", "gene_name": "Fggy", "organism": "Mouse", "refseq_name": "FGGY carbohydrate kinase domain-containing protein isoform a", "refseq_ac": "NP_001106883", "gene_names_uniprotkb": "Fggy", "gene_names_refseq": "2310009E04Rik; Fggy", "protein_names_uniprotkb": "FGGY carbohydrate kinase domain-containing protein; 2.7.1.47; D-ribulokinase FGGY", "protein_names_refseq": "D-ribulokinase FGGY; FGGY carbohydrate kinase domain-containing protein isoform a; FGGY carbohydrate kinase domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75578)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;29220483;31219806;34280510;34428180", "class_list": "", "function": "Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency., [UniProtKB, UniProtKB]; FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling., [RefSeq, PubMed]; The strength of Fggy mRNA expression significantly correlated with increased whole body weight and gonadal fat weight of males but not females., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUF2;Q8K0F0;Q9D7H0", "ec_number_list": "2.7.1.47", "go_molecular_function": "GO:0019150 D-ribulokinase activity;GO:0016301 kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0019321 pentose metabolic process;GO:0046835 carbohydrate phosphorylation;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AJL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52734-1", "uniprot_id": "FGD1_MOUSE", "mass": 106365.0, "length": 960, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 1", "gene_name": "Fgd1", "organism": "Mouse", "refseq_name": "FYVE, RhoGEF and PH domain-containing protein 1", "refseq_ac": "NP_032027", "gene_names_uniprotkb": "Fgd1", "gene_names_refseq": "Fgd1; ZFYVE3", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 1; Faciogenital dysplasia 1 protein homolog; Rho/Rac GEF; Rho/Rac guanine nucleotide exchange factor FGD1; Zinc finger FYVE domain-containing protein 3", "protein_names_refseq": "FYVE, RhoGEF and PH domain-containing protein 1; faciogenital dysplasia 1 protein homolog; rho/Rac GEF; rho/Rac guanine nucleotide exchange factor FGD1; zinc finger FYVE domain-containing protein 3", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); prostate cancer (Disease Ontology:DOID:10283); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); invasive ductal carcinoma (Disease Ontology:DOID:3008); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (mmu:14163); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013148)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12913069;17000758;19261807;21183079;21750661;21965325;25605945;30084848;8535076", "class_list": "", "function": "Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Activation of MLK3 specifically by FGD1/CDC42 is important for skeletal mineralization, [RefSeq, PubMed]; FGD1 is preferentially associated with the trans-Golgi network (TGN), suggesting its involvement in export of proteins from the Golgi., [RefSeq, PubMed]; This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q921L2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0046847 filopodium assembly;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P52734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D7PDD4-1", "uniprot_id": "G6B_MOUSE", "mass": 26010.0, "length": 242, "protein_name": "Megakaryocyte and platelet inhibitory receptor G6b", "gene_name": "Mpig6b", "organism": "Mouse", "refseq_name": "megakaryocyte and platelet inhibitory receptor G6b isoform 1 precursor", "refseq_ac": "NP_001177941", "gene_names_uniprotkb": "Mpig6b; AU023871; G6b-B; G6b", "gene_names_refseq": "C6orf25; G6b; Mpig6b; Ng31", "protein_names_uniprotkb": "Megakaryocyte and platelet inhibitory receptor G6b; ITIM-receptor G6b-B; Immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing platelet receptor", "protein_names_refseq": "ITIM-receptor G6b-B; immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor; megakaryocyte and platelet inhibitory receptor G6b isoform 1 precursor; protein G6b", "tax_id": 10090, "disease": "", "pathway": " (mmu:106722); (R-MMU-114604)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;23112346;29891536", "class_list": "", "function": "Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:23112346). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (By similarity). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:23112346). Appears to operate in a calcium-independent manner (By similarity)., [UniProtKB, PubMed, UniProtKB]; These findings establish G6b-B as a major inhibitory receptor regulating megakaryocyte activation, function, and platelet production. Publication Status: Online-Only, [RefSeq, PubMed]; Uncoupling of G6b-B from Shp1 and Shp2 results in severe macrothrombocytopenia and aberrant platelet function., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0007229 integrin-mediated signaling pathway;GO:0007596 blood coagulation;GO:0030218 erythrocyte differentiation;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D7PDD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59024-1", "uniprot_id": "FKB14_MOUSE", "mass": 24252.0, "length": 211, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP14", "gene_name": "Fkbp14", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP14 isoform 1 precursor", "refseq_ac": "NP_705801", "gene_names_uniprotkb": "Fkbp14", "gene_names_refseq": "FKBP-14; FKBP22; Fkbp14", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP14; 5.2.1.8; FK506-binding protein 14; FKBP-14; PPIase FKBP14; Rotamase", "protein_names_refseq": "PPIase FKBP14; peptidyl-prolyl cis-trans isomerase FKBP14 isoform 1 precursor; peptidyl-prolyl cis-trans isomerase FKBP14; rotamase", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome kyphoscoliotic type 2 (Disease Ontology:DOID:0080735)", "pathway": " (mmu:231997)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;34428180", "class_list": "", "function": "PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P59024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54130-1", "uniprot_id": "FGF9_MOUSE", "mass": 23414.0, "length": 208, "protein_name": "Fibroblast growth factor 9", "gene_name": "Fgf9", "organism": "Mouse", "refseq_name": "fibroblast growth factor 9 isoform 1", "refseq_ac": "NP_038546", "gene_names_uniprotkb": "Fgf9; Fgf-9", "gene_names_refseq": "Eks; FGF-9; Fgf4b; Fgf9; GAF; HBGF-9", "protein_names_uniprotkb": "Fibroblast growth factor 9; FGF-9; GAF; Glia-activating factor; HBGF-9", "protein_names_refseq": "elbow knee synostosis; fibroblast growth factor 4b; fibroblast growth factor 9 isoform 1; glia-activating factor", "tax_id": 10090, "disease": "multiple synostoses syndrome (Disease Ontology:DOID:0050794); multiple synostoses syndrome 3 (Disease Ontology:DOID:0081319); lung cancer (Disease Ontology:DOID:1324); kidney cancer (Disease Ontology:DOID:263); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pleuropulmonary blastoma (Disease Ontology:DOID:4769)", "pathway": " (mmu:14180); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190371); (R-MMU-190372); (R-MMU-190373); (R-MMU-190375); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 31, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10474167;21750661;7656983;8576175;8619928", "class_list": "glycogene", "function": "Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q499I9", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005604 basement membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0003231 cardiac ventricle development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P54130-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35450-1", "uniprot_id": "FKBPL_MOUSE", "mass": 38302.0, "length": 347, "protein_name": "FK506-binding protein-like", "gene_name": "Fkbpl", "organism": "Mouse", "refseq_name": "FK506-binding protein-like", "refseq_ac": "NP_063926", "gene_names_uniprotkb": "Fkbpl; Ng7", "gene_names_refseq": "DIR1; Fkbpl; NG7; Ppiase-X; Wisp39", "protein_names_uniprotkb": "FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; WISp39", "protein_names_refseq": "FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; immunophilin-like protein NG7", "tax_id": 10090, "disease": "", "pathway": " (mmu:56299); (R-MMU-8852276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14656967;15664193;21750661;25767277", "class_list": "", "function": "FKBPL is an important regulator of developmental and pathological angiogenesis., [RefSeq, PubMed]; May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21., [UniProtKB]; Results demonstrate the importance of posttranslational stabilization of p21 protein by WISp39 in regulating cellular p21 activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKG5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045765 regulation of angiogenesis;GO:1905553 regulation of blood vessel branching", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35450-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54998-1", "uniprot_id": "FKBP7_MOUSE", "mass": 24913.0, "length": 218, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP7", "gene_name": "Fkbp7", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP7 isoform 1 precursor", "refseq_ac": "NP_034352", "gene_names_uniprotkb": "Fkbp7; Fkbp23", "gene_names_refseq": "23kDa; FKBP-7; FKBP23; Fkbp7", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP7; 23 kDa FK506-binding protein; 23 kDa FKBP; 5.2.1.8; FK506-binding protein 7; FKBP-23; FKBP-7; PPIase FKBP7; Rotamase", "protein_names_refseq": "23 kDa FK506-binding protein; 23 kDa FKBP; FKBP-23; PPIase FKBP7; peptidyl-prolyl cis-trans isomerase FKBP7 isoform 1 precursor; peptidyl-prolyl cis-trans isomerase FKBP7; rotamase", "tax_id": 10090, "disease": "", "pathway": " (mmu:14231)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14960307;17223077;17425118;21527244;21750661;31219806;34428180;37507081;9806833", "class_list": "", "function": "Binds to Grp78 (Bip) in endoplasmic reticulum., [RefSeq, PubMed]; FKBP23 is demonstrated to mediate functions of BiP by catalyzing the Pro(117)cis/trans conformational interconversion in the ATPase domain of BiP., [RefSeq, PubMed]; In this study, we demonstrate the ability of mFKBP23 to modulate the ATPase activity of BiP, and that the bound mFKBP23, but not the free mFKBP23, can suppress the ATPase activity of mBiP through its PPIase activity., [RefSeq, PubMed]; MFKBP23 binds to immunoglobulin binding protein (mBiP,Hsp70); the binding of the C-terminus is Ca(2+)-dependent and the switch point is between 2 and 3 mM, no binding being detected at high concentration of calcium, [RefSeq, PubMed]; PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O54998-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09160-1", "uniprot_id": "FUT1_MOUSE", "mass": 42394.0, "length": 377, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 1", "gene_name": "Fut1", "organism": "Mouse", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 1 isoform 2", "refseq_ac": "NP_001258910", "gene_names_uniprotkb": "Fut1", "gene_names_refseq": "Fut1; MFUT-1", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 1; 2.4.1.344; 2.4.1.69; Alpha(1,2)FT 1; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; MFUT-1; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; H transferase; alpha(1,2)FT 1; beta-galactoside alpha-1,2-fucosyltransferase; galactoside 2-alpha-L-fucosyltransferase 1; galactoside alpha-(1,2)-fucosyltransferase 1 isoform 2; galactoside alpha-(1,2)-fucosyltransferase 1; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14343); (R-MMU-9033807); (R-MMU-9840309)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11368156;11713270;14967068;16884711;18379136;38840912;9355741", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:11368156, PubMed:14967068, PubMed:16884711). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:16884711). Preferentially fucosylates soluble lactose and to a lesser extent, fucosylates glycolipids gangliosides GA1 and GM1a (PubMed:11368156, PubMed:14967068)., [UniProtKB, PubMed, PubMed, PubMed]; Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is required for the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene impairs development of the olfactory nerve and maturation of the glomerular layer of the main olfactory bulb. Alternative splicing results in multiple transcript variants which encode distinct isoforms. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P97327", "ec_number_list": "2.4.1.344;2.4.1.69;2.4.1.-", "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006664 glycolipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0010595 positive regulation of endothelial cell migration;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 1540, "hit_score": 0.8, "record_id": "O09160-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35392-1", "uniprot_id": "FOXD2_MOUSE", "mass": 48937.0, "length": 492, "protein_name": "Forkhead box protein D2", "gene_name": "Foxd2", "organism": "Mouse", "refseq_name": "forkhead box protein D2", "refseq_ac": "NP_032619", "gene_names_uniprotkb": "Foxd2; Mf2", "gene_names_refseq": "Foxd2; Mf2", "protein_names_uniprotkb": "Forkhead box protein D2; MF-2; Mesoderm/mesenchyme forkhead 2", "protein_names_refseq": "MF-2; forkhead box protein D2; mesoderm/mesenchyme forkhead 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17301)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "38154558;9510020", "class_list": "", "function": "Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT)., [RefSeq, PubMed]; Probable transcription factor involved in embryogenesis and somatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AD43", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35392-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35465-1", "uniprot_id": "FKBP8_MOUSE", "mass": 43529.0, "length": 402, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP8", "gene_name": "Fkbp8", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP8 isoform a", "refseq_ac": "NP_001104536", "gene_names_uniprotkb": "Fkbp8; Fkbp38; Sam11", "gene_names_refseq": "38kDa; FKBP-38; FKBP-8; FKBPR38; Fkbp38; Fkbp8; mFKBP38", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP8; 38 kDa FK506-binding protein; 38 kDa FKBP; 5.2.1.8; FK506-binding protein 8; FKBP-38; FKBP-8; FKBPR38; PPIase FKBP8; Rotamase; mFKBP38", "protein_names_refseq": "38 kDa FK506-binding protein; 38 kDa FKBP; FK506-binding protein 38; PPIase FKBP8; peptidyl-prolyl cis-trans isomerase FKBP8 isoform a; peptidyl-prolyl cis-trans isomerase FKBP8; rotamase", "tax_id": 10090, "disease": "spina bifida (Disease Ontology:DOID:0080016); clubfoot (Disease Ontology:DOID:11836)", "pathway": " (mmu:14232); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10197430;12510191;14612567;14667822;15105374;18459960;21750661;31908024;32969478;33300544;34428180;35537812;36504053;38996665", "class_list": "", "function": "Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development., [UniProtKB]; FKBP38 deletion exacerbates ConA-induced hepatitis by promoting the immune response through the MCP-1/p38 pathway., [RefSeq, PubMed]; FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions., [RefSeq, PubMed]; FKBP8 variants are risk factors for spina bifida., [RefSeq, PubMed]; Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease., [RefSeq, PubMed]; Used systemic gene transfer in tumor-bearing mice to identify novel antiinvasive and antimetastatic functions for Fkbp8, and subsequently for Fkbp1a., [RefSeq, PubMed]; [Fkbp38 deletion induces premature ovarian insufficiency in mice by activating mTOR signaling and inducing granulosa cell apoptosis]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UK86;Q6GTX9;Q811M7;Q811R4;Q8C2F0;Q99L93", "ec_number_list": "5.2.1.8;3.4.19.12;3.6.5.-;3.1.1.29;2.3.2.27;3.4.24.56", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0097718 disordered domain specific binding;GO:0044183 protein folding chaperone;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0070585 protein localization to mitochondrion;GO:0043066 negative regulation of apoptotic process;GO:0001933 negative regulation of protein phosphorylation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35465-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70514-1", "uniprot_id": "FGFP1_MOUSE", "mass": 28294.0, "length": 251, "protein_name": "Fibroblast growth factor-binding protein 1", "gene_name": "Fgfbp1", "organism": "Mouse", "refseq_name": "fibroblast growth factor-binding protein 1 precursor", "refseq_ac": "NP_001258545", "gene_names_uniprotkb": "Fgfbp1", "gene_names_refseq": "FGF-BP1; FGF-BP; FGFBP-1; Fgfbp1", "protein_names_uniprotkb": "Fibroblast growth factor-binding protein 1; FGF-BP1; FGF-BP; FGF-binding protein 1; FGFBP-1", "protein_names_refseq": "FGF-binding protein 1; fibroblast growth factor-binding protein 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14181); (R-MMU-190377)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11819092;15806171;34341336;35951441;37828378;9178765", "class_list": "", "function": "Acts as a carrier protein that releases fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhances the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity)., [UniProtKB]; Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting FAPalpha-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models. Erratum:[J Clin Invest. 2023 Feb 01;133(3):e168771. doi: 10.1172/JCI168771. PMID: 36719375] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62399", "ec_number_list": "", "go_molecular_function": "GO:0019838 growth factor binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway;GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70514-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88819-1", "uniprot_id": "FUT9_MOUSE", "mass": 42041.0, "length": 359, "protein_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9", "gene_name": "Fut9", "organism": "Mouse", "refseq_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9", "refseq_ac": "NP_034373", "gene_names_uniprotkb": "Fut9", "gene_names_refseq": "Fut9; mFUT9; mFuc-TIX", "protein_names_uniprotkb": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; 2.4.1.152; Fuc-TIX; FucT-IX; Fucosyltransferase 9; Fucosyltransferase IX; Galactoside 3-L-fucosyltransferase", "protein_names_refseq": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; alpha-(1,3)-fucosyltransferase 9; fuc-TIX; fucT-IX; fucosyltransferase IX; galactoside 3-L-fucosyltransferase", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:14348); (R-MMU-9037629)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12626397;15121843;16973732;22645129;26244810;30476078;30899004;34203471;9756916", "class_list": "glycogene;glycosyltransferase", "function": "Alpha1,3-fucosyltransferase IX (Fut9)regulates expression of the Lewis X (Lex) carbohydrate structure in brain development, [RefSeq, PubMed]; Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (By similarity) (PubMed:12626397, PubMed:15121843, PubMed:16973732, PubMed:22645129, PubMed:9756916). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity) (PubMed:16973732, PubMed:22645129). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity). Can also modify milk oligosaccharides in particular type 2 tetrasaccharide LNnT (By similarity) (PubMed:9756916)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; It sought to transcriptionally activate the Fut9 gene in the well-known murine colorectal cancer cell line, MC38, which lacks expression of the FUT4 and FUT9 enzymes., [RefSeq, PubMed]; N-linked glycan mass spectrometry profile of wild-type mouse kidney glycoproteins revealed the presence of abundant terminal fucoses, which were lost following knockout of the Fut9 gene, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ63", "ec_number_list": "2.4.1.152;2.4.1.-", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 1336, "hit_score": 1.4, "record_id": "O88819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88842-1", "uniprot_id": "FGD3_MOUSE", "mass": 80624.0, "length": 733, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 3", "gene_name": "Fgd3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fgd3", "gene_names_refseq": "", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (R-MMU-193648); (R-MMU-416482); (R-MMU-9013148)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10721717;19144319;21750661;25605945;34428180", "class_list": "", "function": "Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RT26;Q8BQ72", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0046847 filopodium assembly;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88842-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36363-1", "uniprot_id": "FGF7_MOUSE", "mass": 22347.0, "length": 194, "protein_name": "Fibroblast growth factor 7", "gene_name": "Fgf7", "organism": "Mouse", "refseq_name": "fibroblast growth factor 7 precursor", "refseq_ac": "NP_032034", "gene_names_uniprotkb": "Fgf7; Fgf-7; Kgf", "gene_names_refseq": "Fgf5b; Fgf7; Kgf", "protein_names_uniprotkb": "Fibroblast growth factor 7; FGF-7; HBGF-7; Heparin-binding growth factor 7; KGF; Keratinocyte growth factor", "protein_names_refseq": "FGF-7; HBGF-7; Keratinocyte growth factor; fibroblast growth factor 5b; fibroblast growth factor 7 precursor; heparin-binding growth factor 7", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); prostate cancer (Disease Ontology:DOID:10283); prostatic hypertrophy (Disease Ontology:DOID:11132); leiomyoma (Disease Ontology:DOID:127); squamous cell carcinoma (Disease Ontology:DOID:1749); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:14178); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190377); (R-MMU-5654221); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654727); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "24447999;34428180;8186145", "class_list": "glycogene", "function": "Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 1, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 1, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043129 surfactant homeostasis;GO:0043410 positive regulation of MAPK cascade;GO:0030324 lung development;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P36363-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47931-1", "uniprot_id": "FST_MOUSE", "mass": 37866.0, "length": 344, "protein_name": "Follistatin", "gene_name": "Fst", "organism": "Mouse", "refseq_name": "follistatin isoform FST315 precursor", "refseq_ac": "NP_001288302", "gene_names_uniprotkb": "Fst", "gene_names_refseq": "FS; Fst", "protein_names_uniprotkb": "Follistatin; Activin-binding protein; FS", "protein_names_refseq": "activin-binding protein; follistatin isoform FST315 precursor", "tax_id": 10090, "disease": "restrictive dermopathy (Disease Ontology:DOID:0060762); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (mmu:14313); (R-MMU-2473224)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "20032047;20810712;21750661;22711699;7600958;7885475;7956942;9178255", "class_list": "", "function": "Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:7885475, PubMed:20810712). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (By similarity). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (PubMed:22711699, PubMed:20810712). Also promotes neural differentiation by antagonizing the action BMP4 (PubMed:9178255). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The FST288-only isoform is sufficient for development. Loss of FST303 and FST315 isoforms results in fertility defects that resemble activin hyperactivity and premature ovarian failure., [RefSeq, PubMed]; The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H6P0", "ec_number_list": "", "go_molecular_function": "GO:0038102 activin receptor antagonist activity;GO:0043395 heparan sulfate proteoglycan binding;GO:0048185 activin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0001501 skeletal system development;GO:0030509 BMP signaling pathway;GO:0042475 odontogenesis of dentin-containing tooth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58468-1", "uniprot_id": "SLX9_MOUSE", "mass": 24814.0, "length": 219, "protein_name": "Ribosome biogenesis protein SLX9 homolog", "gene_name": "Slx9", "organism": "Mouse", "refseq_name": "ribosome biogenesis protein SLX9 homolog", "refseq_ac": "NP_598759", "gene_names_uniprotkb": "Slx9; Fam207a", "gene_names_refseq": "1810008A18Rik; Fam207a; Slx9", "protein_names_uniprotkb": "Ribosome biogenesis protein SLX9 homolog", "protein_names_refseq": "family with sequence similarity 207, member A; protein FAM207A; ribosome biogenesis protein SLX9 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:108707)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11707072;19144319;21183079;34428180", "class_list": "", "function": "May be involved in ribosome biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P58468-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03160-1", "uniprot_id": "GRB7_MOUSE", "mass": 59959.0, "length": 535, "protein_name": "Growth factor receptor-bound protein 7", "gene_name": "Grb7", "organism": "Mouse", "refseq_name": "growth factor receptor-bound protein 7", "refseq_ac": "NP_034476", "gene_names_uniprotkb": "Grb7", "gene_names_refseq": "Grb7; mKIAA4028", "protein_names_uniprotkb": "Growth factor receptor-bound protein 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein", "protein_names_refseq": "GRB7 adapter protein; Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7); epidermal growth factor receptor GRB-7; growth factor receptor-bound protein 7", "tax_id": 10090, "disease": "gastrointestinal carcinoma (Disease Ontology:DOID:0050922); esophageal carcinoma (Disease Ontology:DOID:1107); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); esophagus adenocarcinoma (Disease Ontology:DOID:4914); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:14786); (R-MMU-1306955); (R-MMU-1433557); (R-MMU-186763); (R-MMU-210993); (R-MMU-8853659); (R-MMU-9696273)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10377264;10521483;1409582;17242355;17318180;18273060;21750661;34428180;38578949;8631863;8940081", "class_list": "", "function": "Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress., [UniProtKB, PubMed, PubMed]; Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH55", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0042995 cell projection;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0017148 negative regulation of translation;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03160-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKS9-1", "uniprot_id": "PUM3_MOUSE", "mass": 72800.0, "length": 647, "protein_name": "Pumilio homolog 3", "gene_name": "Pum3", "organism": "Mouse", "refseq_name": "pumilio homolog 3", "refseq_ac": "NP_803425", "gene_names_uniprotkb": "Pum3; D19Bwg1357e; Kiaa0020", "gene_names_refseq": "1110069H02Rik; D19Bwg1357e; Pum3", "protein_names_uniprotkb": "Pumilio homolog 3", "protein_names_refseq": "pumilio homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:52874)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19319195;21750661;23806337;31219806;34428180;36210013;37194574", "class_list": "", "function": "Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pum3 is dispensable for mouse oocyte maturation and embryo development in vitro., [RefSeq, PubMed]; This gene encodes a member of the evolutionarily conserved Pumilio and Fem-3 mRNA-binding factor family of proteins, which are characterized by tandem 36 amino acid pumilio homolog domains and which function in diverse biological processes. This protein belongs to a group of atypical Pumilio and Fem-3 mRNA-binding factor proteins, whose members are distinguished from other Pumilio and Fem-3 mRNA-binding factor proteins by a novel protein fold with 11 pumilio homolog domains and an ability to bind to DNA and single- and double-stranded RNA without sequence specificity. In mouse, lower levels of gene expression have been correlated with increased testicular germ cell tumors. A pseudogene of this gene is found on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0E6;Q8BU15", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005694 chromosome", "go_biological_process": "GO:0006417 regulation of translation;GO:0010835 regulation of protein ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BKS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58389-1", "uniprot_id": "PTPA_MOUSE", "mass": 36710.0, "length": 323, "protein_name": "Serine/threonine-protein phosphatase 2A activator", "gene_name": "Ptpa", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A activator isoform 2", "refseq_ac": "NP_620087", "gene_names_uniprotkb": "Ptpa; Ppp2r4", "gene_names_refseq": "2610042B21Rik; PR53; Ppp2r4; Ptpa", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A activator; 5.2.1.8; PP2A, subunit B', PR53 isoform; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B'", "protein_names_refseq": "phosphotyrosyl phosphatase activator; protein phosphatase 2A activator, regulatory subunit B; protein phosphatase 2A, regulatory subunit B (PR 53); serine/threonine-protein phosphatase 2A activator isoform 2; serine/threonine-protein phosphatase 2A activator; serine/threonine-protein phosphatase 2A regulatory subunit 4; serine/threonine-protein phosphatase 2A regulatory subunit B'", "tax_id": 10090, "disease": "Parkinson's disease 25 (Disease Ontology:DOID:0070486)", "pathway": " (mmu:110854)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12952889;17333320;19458393;21750661;22645316;25428506;31160454;31219806;32848054;35822049;37166997;40885482", "class_list": "", "function": "Findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3-dependent apoptosis, [RefSeq, PubMed]; Oxidative stress regulates the phosphorylation status of nonribosomal rpS3 by both activating PKCdelta and blocking the PP2A interaction with rpS3, [RefSeq, PubMed]; PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (By similarity). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (By similarity). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (By similarity). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (By similarity). Is involved in apoptosis; the function appears to be independent from PP2A (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results implicate a critical role of UBE3A-PTPA-PP2A signaling in the pathogenesis of UBE3A-related disorders and suggest that PP2A-based drugs could be potential therapeutic candidates for treatment of UBE3A-related disorders, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P58389-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0V2N1-1", "uniprot_id": "PTPRS_MOUSE", "mass": 211904.0, "length": 1907, "protein_name": "Receptor-type tyrosine-protein phosphatase S", "gene_name": "Ptprs", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase S isoform 2 precursor", "refseq_ac": "NP_001239382", "gene_names_uniprotkb": "Ptprs", "gene_names_refseq": "PTP-NU3; PTPNU-3; PTPsigma; PTP; Ptprs; Ptpt9; R-PTP-S; R-PTP-sigma; RPTPsigma", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase S; 3.1.3.48; PTPNU-3; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase sigma", "protein_names_refseq": "Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; receptor-type tyrosine-protein phosphatase S isoform 2 precursor; tissue-specific protein tyrosine phosphatase", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:19280); (R-MMU-388844); (R-MMU-8849932)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10080191;15797710;16075062;19780196;19833921;21454754;21750661;22027896;22406547;22519304;25385546;25428506;26231120;26495903;26740625;31219806;33300544;34428180;37828378;40885482;7529177", "class_list": "", "function": "Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19780196, PubMed:19833921, PubMed:21454754, PubMed:22406547, PubMed:22519304). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as a tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEC3;Q3TXC9;Q4JFC7;Q5XJV4;Q64503;Q64699;Q7TT17", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;2.7.10.1;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0035374 chondroitin sulfate binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0099054 presynapse assembly;GO:0007165 signal transduction;GO:0021510 spinal cord development;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "B0V2N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922R0-1", "uniprot_id": "PRKX_MOUSE", "mass": 40467.0, "length": 355, "protein_name": "cAMP-dependent protein kinase catalytic subunit PRKX", "gene_name": "Prkx", "organism": "Mouse", "refseq_name": "cAMP-dependent protein kinase catalytic subunit PRKX isoform 1", "refseq_ac": "NP_058675", "gene_names_uniprotkb": "Prkx; Pkare", "gene_names_refseq": "PKX1; Pkare; Prkx", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit PRKX; 2.7.11.1; PKA-related protein kinase; PrKX; Protein kinase X-linked; Protein kinase X; Serine/threonine-protein kinase PRKX", "protein_names_refseq": "PKA-related protein kinase; cAMP-dependent protein kinase catalytic subunit PRKX isoform 1; cAMP-dependent protein kinase catalytic subunit PRKX; putative serine/threonine kinase; serine/threonine-protein kinase PRKX", "tax_id": 10090, "disease": "", "pathway": " (mmu:19108)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10729225;15345747;15879576;16236808;19367327;20819953;21183079;21684272;21750661;26740625", "class_list": "", "function": "Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation., [UniProtKB, PubMed, PubMed, PubMed]; The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could contribute to the stimulating role of PRKX in angiogenesis. Erratum:[Dev Biol. 2013 Sep 15;381(2):502], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVU0;Q3UCD1;Q8BHD6;Q9QZ12", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0060562 epithelial tube morphogenesis;GO:2000696 regulation of epithelial cell differentiation involved in kidney development;GO:0060993 kidney morphogenesis;GO:0001525 angiogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q922R0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q612-1", "uniprot_id": "PTPRO_MOUSE", "mass": 138589.0, "length": 1226, "protein_name": "Receptor-type tyrosine-protein phosphatase O", "gene_name": "Ptpro", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase O isoform 1 precursor", "refseq_ac": "NP_035346", "gene_names_uniprotkb": "Ptpro; GLEPP1; PTPU2; Ptpn15", "gene_names_refseq": "D28; GLEPP1; PTPBK; PTPROt; PTPU2; PTPoc; PTPphi; Ptpn15; Ptpro; R-PTP-O", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase O; 3.1.3.48; Glomerular epithelial protein 1; PTP-U2; PTPase U2; Protein tyrosine phosphatase U2; R-PTP-O", "protein_names_refseq": "PTPase U2; glomerular epithelial protein 1; protein tyrosine phosphatase U2; protein tyrosine phosphatase, non-receptor type 15; receptor protein tyrosine phosphatase RO; receptor-type tyrosine-protein phosphatase O isoform 1 precursor; receptor-type tyrosine-protein phosphatase O", "tax_id": 10090, "disease": "nephrotic syndrome type 6 (Disease Ontology:DOID:0080384)", "pathway": " (mmu:19277)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11086029;19144319;20398064;21183079;21750661;30899004;34428180;37485875;37985496;38735138", "class_list": "", "function": "Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment. Publication Status: Online-Only, [RefSeq, PubMed]; Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis., [RefSeq, PubMed]; PTPRO inhibits LPS-induced apoptosis in alveolar epithelial cells., [RefSeq, PubMed]; Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSY7", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding;GO:0017147 Wnt-protein binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0036060 slit diaphragm assembly;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0003093 regulation of glomerular filtration;GO:0000902 cell morphogenesis;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "E9Q612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q0N2-1", "uniprot_id": "PTPRH_MOUSE", "mass": 106952.0, "length": 971, "protein_name": "Receptor-type tyrosine-protein phosphatase H", "gene_name": "Ptprh", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase H precursor", "refseq_ac": "NP_997153", "gene_names_uniprotkb": "Ptprh; SAP-1", "gene_names_refseq": "Ptprh; R-PTP-H; sap-1", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase H; 3.1.3.48; R-PTP-H; SAP-1; Stomach cancer-associated protein tyrosine phosphatase 1", "protein_names_refseq": "receptor type protein tyrosine phosphatase sap-1; receptor-type tyrosine-protein phosphatase H precursor; receptor-type tyrosine-protein phosphatase H; stomach cancer-associated protein tyrosine phosphatase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545902)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19170756;20398064;26195794;28431964", "class_list": "", "function": "Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of Jurkat cells (By similarity). Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response (PubMed:26195794)., [UniProtKB, PubMed, UniProtKB]; SAP-1 and CEACAM20 thus constitute a regulatory system through which the intestinal epithelium contributes to intestinal immunity., [RefSeq, PubMed]; The results of this study suggest the partial contribution of SAP-1 to the regulated transport of hydrophilic macromolecules through paracellular tight junctions., [RefSeq, PubMed]; These results thus suggest that SAP-1 is a microvillus-specific receptor-type protein tyrosine phosphatase that regulates intestinal tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B6ZDS3;Q8BIW7", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0045296 cadherin binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0016324 apical plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:0007165 signal transduction;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q0N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU22-1", "uniprot_id": "PTN4_MOUSE", "mass": 105832.0, "length": 926, "protein_name": "Tyrosine-protein phosphatase non-receptor type 4", "gene_name": "Ptpn4", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 4", "refseq_ac": "NP_064317", "gene_names_uniprotkb": "Ptpn4", "gene_names_refseq": "PTPMEG; Ptn4; Ptpn4; TEP/mPTPMEG; TEP; hPTP-MEG", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 4; 3.1.3.48; Testis-enriched protein tyrosine phosphatase", "protein_names_refseq": "testis-enriched protein tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:19258); (R-MMU-166016)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11054567;17953619;18614237;21183079;21750661;25825441;33158444;37747937", "class_list": "", "function": "E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4., [RefSeq, PubMed]; Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG. Publication Status: Online-Only, [RefSeq, PubMed]; Our results provide new insight into the TLR4 pathway and identify PTPN4 as a specific inhibitor of TRIF-dependent TLR4 pathway., [RefSeq, PubMed]; Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:17953619, PubMed:25825441). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (PubMed:18614237). May act at junctions between the membrane and the cytoskeleton., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E8E7", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0035254 glutamate receptor binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WU22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08586-1", "uniprot_id": "PTEN_MOUSE", "mass": 47152.0, "length": 403, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "Pten", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "refseq_ac": "NP_032986", "gene_names_uniprotkb": "Pten; Mmac1", "gene_names_refseq": "2310035O07Rik; A130070J02Rik; B430203M17Rik; MMAC1; PTENbeta; Pten; TEP1", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; 3.1.3.-; 3.1.3.16; 3.1.3.48; 3.1.3.67; Inositol polyphosphate 3-phosphatase; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog", "protein_names_refseq": "PTENepsilon; inositol polyphosphate 3-phosphatase; mitochondrial PTENalpha; mutated in multiple advanced cancers 1; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); Cowden syndrome 1 (Disease Ontology:DOID:0050657); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ovarian serous carcinoma (Disease Ontology:DOID:0050933); autism spectrum disorder (Disease Ontology:DOID:0060041); cerebral cavernous malformation (Disease Ontology:DOID:0060669); macrocephaly-autism syndrome (Disease Ontology:DOID:0060867); intestinal pseudo-obstruction (Disease Ontology:DOID:0080072); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); urinary bladder cancer (Disease Ontology:DOID:11054); peripheral nervous system neoplasm (Disease Ontology:DOID:1192); leiomyoma (Disease Ontology:DOID:127); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); biliary atresia (Disease Ontology:DOID:13608); endometrial cancer (Disease Ontology:DOID:1380); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); hemangiopericytoma (Disease Ontology:DOID:264); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); substance-related disorder (Disease Ontology:DOID:303); high grade glioma (Disease Ontology:DOID:3070); angiomyolipoma (Disease Ontology:DOID:3314); bladder squamous cell carcinoma (Disease Ontology:DOID:3742); lung non-small cell carcinoma (Disease Ontology:DOID:3908); follicular thyroid carcinoma (Disease Ontology:DOID:3962); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); esophageal cancer (Disease Ontology:DOID:5041); Cowden syndrome (Disease Ontology:DOID:6457); hepatocellular carcinoma (Disease Ontology:DOID:684); stomach disease (Disease Ontology:DOID:76); sporadic breast cancer (Disease Ontology:DOID:8029); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); brain disease (Disease Ontology:DOID:936); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:19211); (R-MMU-1660499); (R-MMU-1855204); (R-MMU-199418); (R-MMU-202424); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-8948747); (R-MMU-8948751)", "pathway_count": 9, "publication_count": 31, "publication_id_list": "10339565;17242355;17875968;17975737;19403525;19473982;19778506;20008297;20940307;21183079;24569712;25594415;25605945;25801959;26222260;28513223;29069834;29530069;29775456;30134988;31219806;31474552;31492966;31500401;32034125;33039560;33083717;33428810;34428180;35603900;9090379", "class_list": "", "function": "Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:10339565, PubMed:19778506, PubMed:31492966). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (By similarity). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (By similarity). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:10339565, PubMed:19778506). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFB0;Q542G1", "ec_number_list": "3.1.3.48;3.4.19.12;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.11.1;3.4.25.1;3.1.3.86;3.1.3.95;3.1.3.36;2.3.2.27;2.3.2.26;3.1.3.74;3.1.3.53;2.4.2.-;2.4.2.30;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;2.7.10.2;3.1.3.62;3.1.3.80", "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity;GO:0005161 platelet-derived growth factor receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0060024 rhythmic synaptic transmission;GO:0032535 regulation of cellular component size;GO:0033032 regulation of myeloid cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "O08586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18052-1", "uniprot_id": "PTPRA_MOUSE", "mass": 93698.0, "length": 829, "protein_name": "Receptor-type tyrosine-protein phosphatase alpha", "gene_name": "Ptpra", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor", "refseq_ac": "NP_033006", "gene_names_uniprotkb": "Ptpra; Lrp; Ptpa", "gene_names_refseq": "Ptpalpha; Ptpa; Ptpra; Rptpalpha; Rptralpha; Rptra", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase alpha; 3.1.3.48; LCA-related phosphatase; PTPTY-28; Protein-tyrosine phosphatase alpha; R-PTP-alpha", "protein_names_refseq": "LCA-related phosphatase; PTPTY-28; R-PTP-alpha; protein-tyrosine phosphatase alpha; receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor; receptor-type tyrosine-protein phosphatase alpha", "tax_id": 10090, "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (mmu:19262); (R-MMU-375165); (R-MMU-5673001)", "pathway_count": 3, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;12834342;1454056;15592455;1590786;16075062;17947660;18034455;19144319;1932742;21183079;2162042;2166945;21750661;22801373;30899004;33300544;34428180;35670474;37402225;37453647;37828378;39627609;7518772;7537734;7832766;8406469;8700232", "class_list": "", "function": "Clustering of phosphatase RPTPalpha promotes Src signaling and the arthritogenic action of synovial fibroblasts., [RefSeq, PubMed]; PTPalpha promotes fibroproliferative responses after acute lung injury., [RefSeq, PubMed]; Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (PubMed:22801373). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (PubMed:22801373)., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2AHF2;Q61808", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.2.1.31;2.7.10.1;3.6.5.2;2.7.11.17;2.7.10.2;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18;2.7.11.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0016020 membrane;GO:0043235 receptor complex;GO:0097060 synaptic membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P18052-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42669-1", "uniprot_id": "PURA_MOUSE", "mass": 34884.0, "length": 321, "protein_name": "Transcriptional activator protein Pur-alpha", "gene_name": "Pura", "organism": "Mouse", "refseq_name": "transcriptional activator protein Pur-alpha", "refseq_ac": "NP_033015", "gene_names_uniprotkb": "Pura", "gene_names_refseq": "6330411E07Rik; CAGER-1; Pur-alpha; Pura; ssCRE-BP", "protein_names_uniprotkb": "Transcriptional activator protein Pur-alpha; Purine-rich single-stranded DNA-binding protein alpha", "protein_names_refseq": "purine-rich single-stranded DNA-binding protein alpha; transcriptional activator protein Pur-alpha", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 31 (Disease Ontology:DOID:0070061)", "pathway": " (mmu:19290)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10318844;12147688;17242355;22645316;24788674;25153642;27651147;28135057;28528544;33300544;33333713;34108502;34428180;37453647;37909329;7959008;9334258", "class_list": "", "function": "Analysis of the role of Puralpha in the pathogenesis of Alzheimer's disease based on RNA-seq and ChIP-seq. Publication Status: Online-Only, [RefSeq, PubMed]; DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha. Publication Status: Online-Only, [RefSeq, PubMed]; Puralpha regulates the induction of Znf179 transcription during neuronal differentiation., [RefSeq, PubMed]; Quantitative immunohistochemical assays of the vermal region of the cerebellum and CA1-3 regions of the hippocampus revealed reduced numbers of neurons in general, as well as reduced numbers of Pur-alpha+-immunopositive neurons and dendrites in heterozygous Pur-alpha mice, compared to wild-type littermates, [RefSeq, PubMed]; This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the c-Myc gene. May play a role in the initiation of DNA replication and in recombination., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0098963 dendritic transport of messenger ribonucleoprotein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P42669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64487-4", "uniprot_id": "PTPRD_MOUSE", "mass": 214410.0, "length": 1912, "protein_name": "Receptor-type tyrosine-protein phosphatase delta", "gene_name": "Ptprd", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase delta isoform 1 precursor", "refseq_ac": "NP_035341", "gene_names_uniprotkb": "Ptprd", "gene_names_refseq": "1110002J03Rik; 3000002J10Rik; B230219D21Rik; Ptprd; R-PTP-delta", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase delta; 3.1.3.48; Protein-tyrosine phosphatase delta; R-PTP-delta", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase delta isoform 1 precursor; receptor-type tyrosine-protein phosphatase delta", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); hypertension (Disease Ontology:DOID:10763); azoospermia (Disease Ontology:DOID:14227); coronary artery disease (Disease Ontology:DOID:3393); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19266); (R-MMU-388844); (R-MMU-8849932)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11978849;21940441;25908590;25989451;28011936;30899004;34203471;34428180;37828378;38890753;7832766;8355697", "class_list": "", "function": "Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451)., [UniProtKB, PubMed, PubMed]; Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G3X9S7;Q64486;Q64488;Q64495;Q8VBV0", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.2.2.6;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0050839 cell adhesion molecule binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0042734 presynaptic membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0099054 presynapse assembly;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0050776 regulation of immune response;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q64487-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R326-1", "uniprot_id": "PSPC1_MOUSE", "mass": 58758.0, "length": 523, "protein_name": "Paraspeckle component 1", "gene_name": "Pspc1", "organism": "Mouse", "refseq_name": "paraspeckle component 1 isoform 1", "refseq_ac": "NP_079958", "gene_names_uniprotkb": "Pspc1; Psp1", "gene_names_refseq": "5730470C09Rik; PSP1; Pspc1", "protein_names_uniprotkb": "Paraspeckle component 1; Paraspeckle protein 1; mPSP1", "protein_names_refseq": "paraspeckle component 1 isoform 1; paraspeckle component 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66645)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15140795;16239143;16641145;21750661;22966205;24129315;27802388;29187734;31219806;31844057;33300544;34490876", "class_list": "", "function": "MPSP1 may regulate multiple phases of important nuclear events during spermatogenesis., [RefSeq, PubMed]; PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation., [RefSeq, PubMed]; PSPC1, NONO, and SFPQ form complexes with each other in Sertoli cells and may regulate androgen receptor-mediated transcriptional activity, [RefSeq, PubMed]; RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (PubMed:16641145). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:22966205). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUK2;Q9CYH1;Q9D0M8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08775-1", "uniprot_id": "RUNX2_MOUSE", "mass": 66205.0, "length": 607, "protein_name": "Runt-related transcription factor 2", "gene_name": "Runx2", "organism": "Mouse", "refseq_name": "runt-related transcription factor 2 isoform 1", "refseq_ac": "NP_001139510", "gene_names_uniprotkb": "Runx2; Aml3; Cbfa1; Osf2; Pebp2a", "gene_names_refseq": "AML3; CBF-alpha-1; Cbfa-1; Cbfa1; Cbf; LS3; Osf2; PEBP2aA; Pebp2a1; Pebpa2a; Runx2", "protein_names_uniprotkb": "Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; CBF-alpha-1; Core-binding factor subunit alpha-1; OSF-2; Oncogene AML-3; Osteoblast-specific transcription factor 2; PEA2-alpha A; PEBP2-alpha A; Polyomavirus enhancer-binding protein 2 alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit", "protein_names_refseq": "AKV core binding factor; PEA2-alpha A; PEBP2 alpha A; SL3-3 enhancer factor 1 alpha A subunit; acute myeloid leukemia 3 protein; core binding factor alpha 1; osteoblast-specific transcription factor 2; polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt-related transcription factor 2 isoform 1; transcription factor Cbfa1/Osf2", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); metabolic acidosis (Disease Ontology:DOID:0050758); glucocorticoid-induced osteoporosis (Disease Ontology:DOID:0060343); metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome (Disease Ontology:DOID:0111513); osteonecrosis (Disease Ontology:DOID:10159); osteoporosis (Disease Ontology:DOID:11476); cleidocranial dysplasia (Disease Ontology:DOID:13994); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12393)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10524201;10660618;15557274;16728642;16751105;17960593;20484411;21239498;21471200;21750661;24028588;24129315;29148101;32782141;34428180;35922041;39800889;8341710;8386878;9182762;9182763;9238031;9651525", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35183;Q08776;Q9JLN0;Q9QUQ6;Q9QY29;Q9R0U4;Q9Z2J7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002051 osteoblast fate commitment;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:1904383 response to sodium phosphate;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q08775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSQ9-1", "uniprot_id": "PB1_MOUSE", "mass": 187188.0, "length": 1634, "protein_name": "Protein polybromo-1", "gene_name": "Pbrm1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pbrm1; Baf180; Pb1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein polybromo-1; BAF180; BRG1-associated factor 180", "protein_names_refseq": "", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); lung small cell carcinoma (Disease Ontology:DOID:5409); Crohn's disease (Disease Ontology:DOID:8778); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:66923); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933939)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17640523;17947660;18299400;19144319;21183079;21750661;22872234;22952240;23806337;25428506;26601204;30084848;30779550;31219806;34428180;35820727;39627609", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPW1;Q05C64;Q05CL6;Q7TMP1;Q7TNU2;Q9CV51", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0016363 nuclear matrix;GO:0000776 kinetochore", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8BSQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGE9-1", "uniprot_id": "RGS12_MOUSE", "mass": 149637.0, "length": 1381, "protein_name": "Regulator of G protein signaling 12", "gene_name": "Rgs12", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 12 isoform A", "refseq_ac": "NP_775578", "gene_names_uniprotkb": "Rgs12", "gene_names_refseq": "1200016K18Rik; 4632412M04Rik; E130309H11; Rgs12", "protein_names_uniprotkb": "Regulator of G protein signaling 12; RGS12", "protein_names_refseq": "regulator of G-protein signaling 12 isoform A", "tax_id": 10090, "disease": "", "pathway": " (mmu:71729); (R-MMU-418594)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15525537;16145674;17042716;21183079;21750661;24129315;30016717;32842837;34428180;36260679;36797232", "class_list": "", "function": "Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo., [RefSeq, PubMed]; RGS12 is essential for the terminal differentiation of osteoclasts induced by RANKL., [RefSeq, PubMed]; RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells., [RefSeq, PubMed]; RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling. Publication Status: Online-Only, [RefSeq, PubMed]; RGS12 splice variants exhibit differential spatiotemporal patterns of expression during postimplantation embryogenesis, suggesting nonoverlapping roles, [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9PXX2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0038032 termination of G protein-coupled receptor signaling pathway;GO:0007165 signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CGE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49817-1", "uniprot_id": "CAV1_MOUSE", "mass": 20539.0, "length": 178, "protein_name": "Caveolin-1", "gene_name": "Cav1", "organism": "Mouse", "refseq_name": "caveolin-1 isoform 2", "refseq_ac": "NP_001229993", "gene_names_uniprotkb": "Cav1; Cav", "gene_names_refseq": "Cav-1; Cav1; Cav", "protein_names_uniprotkb": "Caveolin-1", "protein_names_refseq": "caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; caveolin-1 isoform 2; caveolin-1", "tax_id": 10090, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); alcohol-associated liver disease (Disease Ontology:DOID:0070658); congenital generalized lipodystrophy type 3 (Disease Ontology:DOID:0111137); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); acoustic neuroma (Disease Ontology:DOID:12689); leiomyoma (Disease Ontology:DOID:127); primary pulmonary hypertension (Disease Ontology:DOID:14557); hypothyroidism (Disease Ontology:DOID:1459); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); psoriasis (Disease Ontology:DOID:8893); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12389); (R-MMU-203615); (R-MMU-203641); (R-MMU-209968); (R-MMU-210991); (R-MMU-4641262); (R-MMU-5218920); (R-MMU-8980692); (R-MMU-9009391); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9035034); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 22, "publication_count": 47, "publication_id_list": "10631317;10816572;11094059;11805080;12036959;12531427;12921535;15592455;15692085;16877379;17517963;18506777;19074371;19546242;19713536;21183079;21385608;21610094;21750661;23372929;23472139;23806337;24244013;25097454;25238970;25407919;25572853;27259249;27572515;27658533;28542134;30188967;31219806;31599954;32152405;32238105;32685103;33314143;34321069;34428180;34799735;35820727;36288343;37507081;37828378;7608210;7926819", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242). Interacts directly with G protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (PubMed:34799735)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Binds 20(S)-hydroxycholesterol (20(S)-OHC)., [UniProtKB, UniProtKB, UniProtKB]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1X7;Q8CBP4;Q9QYH3;Q9QYH4", "ec_number_list": "", "go_molecular_function": "GO:0070320 inward rectifier potassium channel inhibitor activity;GO:0060090 molecular adaptor activity;GO:0008142 oxysterol binding;GO:0005102 signaling receptor binding;GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0003057 regulation of the force of heart contraction by chemical signal;GO:0032507 maintenance of protein location in cell;GO:0048550 negative regulation of pinocytosis;GO:0052547 regulation of peptidase activity", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P49817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTT2-1", "uniprot_id": "PSD1_MOUSE", "mass": 109687.0, "length": 1024, "protein_name": "PH and SEC7 domain-containing protein 1", "gene_name": "Psd", "organism": "Mouse", "refseq_name": "PH and SEC7 domain-containing protein 1 isoform 2", "refseq_ac": "NP_001334383", "gene_names_uniprotkb": "Psd; Efa6a; Kiaa2011; Psd1", "gene_names_refseq": "1110007H17Rik; A930015K15; Efa6a; Efa6; Psdl; Psd; mKIAA2011", "protein_names_uniprotkb": "PH and SEC7 domain-containing protein 1; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ARF6 A; Exchange factor for ARF6; Pleckstrin homology and SEC7 domain-containing protein 1", "protein_names_refseq": "PH and SEC7 domain-containing protein 1 isoform 2; PH and SEC7 domain-containing protein 1; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; exchange factor for ARF6 A; pleckstrin and Sec7 domain containing homolog; pleckstrin homology and SEC7 domain-containing protein 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:73728)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15540117;16707115;17114649;17298598;19494129;21183079;21750661;31219806;38725127;39126836", "class_list": "", "function": "Determined the complete primary sequence of mouse EFA6D encoding a protein of 1004 amino acids with a calculated molecular weight of 111,207 Da., [RefSeq, PubMed]; EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines, [RefSeq, PubMed]; EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells., [RefSeq, PubMed]; Guanine nucleotide exchange factor for ARF6 (By similarity). Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers (PubMed:19494129)., [UniProtKB, PubMed, UniProtKB]; Localization of EFA6A, an exchange factor for Arf6, in Z-lines and sarcoplasmic reticulum membranes in addition to myofilaments in I-domains of skeletal myofibers of peri-natal mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RS07;B7ZNN7;Q3TY69;Q6PE10", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0032154 cleavage furrow;GO:0032587 ruffle membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction;GO:0099562 maintenance of postsynaptic density structure;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5DTT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDS3-1", "uniprot_id": "CBX7_MOUSE", "mass": 18109.0, "length": 158, "protein_name": "Chromobox protein homolog 7", "gene_name": "Cbx7", "organism": "Mouse", "refseq_name": "chromobox protein homolog 7", "refseq_ac": "NP_659060", "gene_names_uniprotkb": "Cbx7; D15Ertd417e", "gene_names_refseq": "1600014J01Rik; Cbx7; D15Ertd417e", "protein_names_uniprotkb": "Chromobox protein homolog 7", "protein_names_refseq": "chromobox homolog 7; chromobox protein homolog 7", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); anaplastic thyroid carcinoma (Disease Ontology:DOID:0080522); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); clear cell adenocarcinoma (Disease Ontology:DOID:4468); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); myeloid leukemia (Disease Ontology:DOID:8692); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:52609)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14647293;16537902;20541999;21750661;22226355;34428180;37158107;38744845", "class_list": "", "function": "CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16537902, PubMed:22226355). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3) (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (PubMed:16537902, PubMed:22226355). Trimethylation at 'Lys-27' (H3K27me3) is important for chromatin recruitment (PubMed:16537902, PubMed:22226355). May possibly also bind trimethylated lysine residues in other proteins (in vitro) (PubMed:16537902). Binds non-coding, single-stranded RNA and double-stranded RNA (PubMed:16537902, PubMed:20541999). Plays a role in the timely repression of differentiation-specific genes in pluripotent embryonic stem cells to maintain the undifferentiated state (PubMed:22226355). Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity (PubMed:14647293)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 pathways Erratum:[Nat Cell Biol. 2022 Sep;24(9):1445. doi: 10.1038/s41556-022-00956-2. PMID: 35941232], [RefSeq, PubMed]; Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003727 single-stranded RNA binding;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VDS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63013-1", "uniprot_id": "PRRX1_MOUSE", "mass": 27269.0, "length": 245, "protein_name": "Paired mesoderm homeobox protein 1", "gene_name": "Prrx1", "organism": "Mouse", "refseq_name": "paired mesoderm homeobox protein 1 isoform a", "refseq_ac": "NP_035257", "gene_names_uniprotkb": "Prrx1; Pmx1; Pmx", "gene_names_refseq": "A230024N07Rik; K-2; MHox1; Pmx1; Pmx; Prrx1; Prx1; mHox", "protein_names_uniprotkb": "Paired mesoderm homeobox protein 1; Homeobox protein K-2; MHox; Muscle homeobox protein; PRX-1; Paired-related homeobox protein 1", "protein_names_refseq": "homeobox protein K-2; homeobox protein mHox; muscle homeobox protein; paired mesoderm homeobox protein 1 isoform a; paired mesoderm homeobox protein 1; paired-related homeobox protein 1", "tax_id": 10090, "disease": "agnathia-otocephaly complex (Disease Ontology:DOID:0060341)", "pathway": " (mmu:18933)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11373278;1360403;1383943;21750661;23806337;25153642;28135057;28528544;30084848;34428180;35589735;36456880;7910581", "class_list": "", "function": "Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (PubMed:1360403). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (PubMed:36456880)., [UniProtKB, PubMed, PubMed, PubMed]; Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain., [UniProtKB, PubMed]; Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P43271;Q02810;Q569N6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070570 regulation of neuron projection regeneration;GO:0045880 positive regulation of smoothened signaling pathway;GO:2000648 positive regulation of stem cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P63013-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61097-1", "uniprot_id": "KSR1_MOUSE", "mass": 96755.0, "length": 873, "protein_name": "Kinase suppressor of Ras 1", "gene_name": "Ksr1", "organism": "Mouse", "refseq_name": "kinase suppressor of Ras 1 isoform 2", "refseq_ac": "NP_001335136", "gene_names_uniprotkb": "Ksr1; Ksr", "gene_names_refseq": "B-KSR1; D11Bhm183e; D11Bhm184e; Ksr1; Ksr; RSU2; hb; mKSR1", "protein_names_uniprotkb": "Kinase suppressor of Ras 1; 2.7.11.1; Protein Hb; mKSR1", "protein_names_refseq": "kinase suppressor of Ras 1 isoform 2; protein Hb", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); breast adenocarcinoma (Disease Ontology:DOID:3458)", "pathway": " (mmu:16706); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5675221)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10409742;10891492;11741534;11786023;12007434;12932319;12941695;15371409;21102438;21183079;21441104;21750661;22206009;23250398;24158441;33766558;7626882;8521512;9858547", "class_list": "", "function": "Calmodulin influences MAPK signaling by binding KSR1., [RefSeq, PubMed]; Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438, PubMed:21441104). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (By similarity). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438). Its kinase activity is unsure (PubMed:21441104). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (PubMed:21441104)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 28, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61648;Q78DX8", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;3.6.5.2;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.6.4.-;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;2.3.2.27;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0007265 Ras protein signal transduction;GO:0043405 regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q61097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35984-1", "uniprot_id": "PBX2_MOUSE", "mass": 45809.0, "length": 430, "protein_name": "Pre-B-cell leukemia transcription factor 2", "gene_name": "Pbx2", "organism": "Mouse", "refseq_name": "pre-B-cell leukemia transcription factor 2", "refseq_ac": "NP_059491", "gene_names_uniprotkb": "Pbx2", "gene_names_refseq": "G17; Pbx2", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 2; Homeobox protein PBX2", "protein_names_refseq": "homeobox protein PBX2; pre-B-cell leukemia transcription factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18515)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10082572;14656967;21183079;21750661;34203471;37414772", "class_list": "", "function": "A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0030326 embryonic limb morphogenesis;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58281-1", "uniprot_id": "OPA1_MOUSE", "mass": 111339.0, "length": 960, "protein_name": "Dynamin-like GTPase OPA1, mitochondrial", "gene_name": "Opa1", "organism": "Mouse", "refseq_name": "dynamin-like GTPase OPA1, mitochondrial isoform 1", "refseq_ac": "NP_001186106", "gene_names_uniprotkb": "Opa1", "gene_names_refseq": "1200011N24Rik; Opa1; lilr3; mKIAA0567", "protein_names_uniprotkb": "Dynamin-like GTPase OPA1, mitochondrial; 3.6.5.5; Large GTP-binding protein; LargeG; Optic atrophy protein 1 homolog", "protein_names_refseq": "dynamin-like 120 kDa protein, mitochondrial; dynamin-like GTPase OPA1, mitochondrial isoform 1; dynamin-like GTPase OPA1, mitochondrial; large GTP-binding protein; largeG; optic atrophy 1 homolog; optic atrophy protein 1 homolog", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 14 (Disease Ontology:DOID:0080336); dominant optic atrophy plus syndrome (Disease Ontology:DOID:0111340); optic atrophy 1 (Disease Ontology:DOID:0111441); Behr syndrome (Disease Ontology:DOID:0111580); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); optic atrophy (Disease Ontology:DOID:5723); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); ocular hypertension (Disease Ontology:DOID:9282); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:74143); (R-MMU-169911)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "11847212;16839884;16839885;17003040;17314202;17428816;18419770;20038678;21081504;21346246;21750661;22433842;24055366;24550258;24616225;24627489;24703695;25298396;26785494;28636943;28746876;31219806;33200421;33237841;33300544;34428180;36171294;36288343;38225406;39627609", "class_list": "", "function": "Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:20038678, PubMed:22433842, PubMed:25298396). The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (By similarity). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (By similarity). Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion (PubMed:20038678, PubMed:22433842). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization by mediating flickering: cleavage by OMA1 leads to excess production of S-OPA1, preventing mitochondrial hyperfusion (PubMed:24627489, PubMed:33200421). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:16839884, PubMed:16839885, PubMed:25298396, PubMed:38225406). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (PubMed:38225406)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:20038678, PubMed:22433842, PubMed:25298396). L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (By similarity). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:16839884, PubMed:16839885, PubMed:25298396, PubMed:38225406). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (PubMed:38225406)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:11847212, PubMed:16839884, PubMed:16839885, PubMed:24055366, PubMed:24616225, PubMed:24627489, PubMed:25298396, PubMed:26785494, PubMed:28636943, PubMed:28746876, PubMed:33200421, PubMed:33237841, PubMed:36171294, PubMed:38225406). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (PubMed:24703695, PubMed:28636943, PubMed:33237841). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (PubMed:33237841). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (PubMed:33200421). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (PubMed:33200421, PubMed:38225406). Involved in remodeling cristae and the release of cytochrome c during apoptosis (PubMed:16839884). Proteolytic processing by PARL in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (PubMed:16839884, PubMed:16839885). Acts as a regulator of T-helper Th17 cells, which are characterized by cells with fused mitochondria with tight cristae, by mediating mitochondrial membrane remodeling: OPA1 is required for interleukin-17 (IL-17) production (PubMed:36171294). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Manipulation of OPA1 isoform 1 levels in induces changes in the mitochondrial network in the cell; mutations of isoform 1 could lead to devastating effects on retinal ganglion cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6Q3;H7BX01;Q3ULA5;Q8BKU7;Q8BLL3;Q8BM08;Q8R3J7", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-;3.4.24.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0097749 membrane tubulation;GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0032740 positive regulation of interleukin-17 production;GO:0016559 peroxisome fission", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P58281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U7U4-1", "uniprot_id": "CA162_MOUSE", "mass": 14354.0, "length": 132, "protein_name": "Transmembrane protein C1orf162 homolog", "gene_name": "I830077J02Rik", "organism": "Mouse", "refseq_name": "transmembrane protein C1orf162 homolog", "refseq_ac": "NP_001028952", "gene_names_uniprotkb": "I830077J02Rik", "gene_names_refseq": "I830077J02Rik", "protein_names_uniprotkb": "Transmembrane protein C1orf162 homolog", "protein_names_refseq": "transmembrane protein C1orf162 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:433638)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19144319;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWJ4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U7U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIS0-1", "uniprot_id": "CAR11_MOUSE", "mass": 134040.0, "length": 1159, "protein_name": "Caspase recruitment domain-containing protein 11", "gene_name": "Card11", "organism": "Mouse", "refseq_name": "caspase recruitment domain-containing protein 11 isoform 1", "refseq_ac": "NP_780571", "gene_names_uniprotkb": "Card11; Carma1", "gene_names_refseq": "0610008L17Rik; 2410011D02Rik; BIMP3; CARMA1; Card11", "protein_names_uniprotkb": "Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 1; Carma 1", "protein_names_refseq": "CARD-containing MAGUK protein 1; carma 1; caspase recruitment domain-containing protein 11 isoform 1; caspase recruitment domain-containing protein 11", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); immunodeficiency 11A (Disease Ontology:DOID:0111957); immunodeficiency 11B (Disease Ontology:DOID:0111958); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (mmu:108723); (R-MMU-1169091); (R-MMU-202424); (R-MMU-2871837); (R-MMU-5607764)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "12154356;12356734;16356855;19917688;21183079;22880103;25428506;26495903;28011936;31219806;34428180", "class_list": "", "function": "Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:12154356, PubMed:12356734, PubMed:16356855). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:12154356, PubMed:12356734, PubMed:16356855). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (By similarity). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (By similarity). Stimulates the phosphorylation of BCL10 (By similarity). Also activates the TORC1 signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA14;Q6KAS3;Q8BYV0", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity;GO:0050700 CARD domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0001772 immunological synapse;GO:0032449 CBM complex", "go_biological_process": "GO:0045061 thymic T cell selection;GO:0045577 regulation of B cell differentiation;GO:0046649 lymphocyte activation;GO:0007165 signal transduction;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CIS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKN6-1", "uniprot_id": "NOVA1_MOUSE", "mass": 51756.0, "length": 507, "protein_name": "RNA-binding protein Nova-1", "gene_name": "Nova1", "organism": "Mouse", "refseq_name": "RNA-binding protein Nova-1 isoform 1", "refseq_ac": "NP_067336", "gene_names_uniprotkb": "Nova1", "gene_names_refseq": "9430099M15Rik; G630039L02; Nova-1; Nova1", "protein_names_uniprotkb": "RNA-binding protein Nova-1; Neuro-oncological ventral antigen 1; Ventral neuron-specific protein 1", "protein_names_refseq": "RNA-binding protein Nova-1 isoform 1; RNA-binding protein Nova-1; neuro-oncological ventral antigen 1; ventral neuron-specific protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:664883)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10719891;10829067;11003693;12808107;14615540;15933722;17065982;21750661;30638744;34203471;35778567;36145242;36716149;39966351;8558240;9154818", "class_list": "", "function": "Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis., [RefSeq, PubMed]; NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons., [RefSeq, PubMed]; Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein which regulates alternative splicing of pre-mRNAs in the brain and spinal cord in a sequence-specific manner (PubMed:10719891, PubMed:14615540, PubMed:15933722, PubMed:17065982, PubMed:8558240, PubMed:9154818). Binds to 5'-YCAY-3' repeats, with a minimum of 2 to 3 repeats necessary for high-affinity binding. Mediates both exon inclusion and exclusion, depending upon the position of its binding site within the pre-mRNA (PubMed:10719891, PubMed:15933722, PubMed:9154818). Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 small nuclear ribonucleoprotein (snRNP) binding and inhibiting exon inclusion, whereas binding to an intronic 5'-YCAY-3' repeat enhances spliceosome assembly and favors exon inclusion (PubMed:17065982). Regulates the splicing of gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) and glycine receptor subunit alpha-2 (GLRA2) pre-mRNAs, among others (PubMed:10719891, PubMed:12808107, PubMed:15933722, PubMed:9154818). Autoregulates its own splicing. Binds to its own exon 4 and directs its exclusion, thus leading to NOVA1 isoform 2 production (PubMed:15933722, PubMed:9154818)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Splicing regulation activity of isoform 2 is similar to that of isoform 1, when tested with minigenes for autosplicing, as well as for GABRG2 and GLRA2 splicing in various cell lines., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8B9", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0007399 nervous system development;GO:0000398 mRNA splicing, via spliceosome;GO:0050684 regulation of mRNA processing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9JKN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01098-1", "uniprot_id": "NMDE3_MOUSE", "mass": 135420.0, "length": 1239, "protein_name": "Glutamate receptor ionotropic, NMDA 2C", "gene_name": "Grin2c", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, NMDA 2C isoform 1 precursor", "refseq_ac": "NP_034480", "gene_names_uniprotkb": "Grin2c", "gene_names_refseq": "GluN2C; Grin2c; NMDAR2C; NR2C", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2C; GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C", "protein_names_refseq": "GluRepsilon3; N-methyl D-aspartate receptor subtype 2C; glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor ionotropic, NMDA 2C isoform 1 precursor; glutamate receptor ionotropic, NMDA 2C", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:14813); (R-MMU-438066); (R-MMU-8849932); (R-MMU-9609736)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;1377365;21183079;22645316;27922130;30899004;34428180;38603856;40885482;7790891;8987814", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:1377365). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (PubMed:8987814). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:1377365). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex (PubMed:27922130)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0005261 monoatomic cation channel activity;GO:0004970 glutamate-gated receptor activity;GO:0016595 glutamate binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:1903539 protein localization to postsynaptic membrane;GO:0007626 locomotory behavior;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0042391 regulation of membrane potential;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q01098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESX4-1", "uniprot_id": "ZCC17_MOUSE", "mass": 27472.0, "length": 241, "protein_name": "Zinc finger CCHC domain-containing protein 17", "gene_name": "Zcchc17", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 17 isoform 1", "refseq_ac": "NP_694800", "gene_names_uniprotkb": "Zcchc17; Ldc4; Ps1d", "gene_names_refseq": "2810055E05Rik; HSPC251; LDC4; Zcchc17; pNO40; pS1D", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 17; Nucleolar protein of 40 kDa; PS1D protein; Putative S1 RNA-binding domain protein; pNO40", "protein_names_refseq": "nucleolar protein of 40 kDa; putative S1 RNA binding domain protein; zinc finger CCHC domain-containing protein 17 isoform 1; zinc finger CCHC domain-containing protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:619605)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12202495;12893261;23806337;26721440;28069438", "class_list": "", "function": "Molecular cloning and characterization; it is localized to nucleoli of diverse cultured cells, with some concentration in the granular component of nucleoli, [RefSeq, PubMed]; PNO40 may function as a general recruiter for nucleolar association of SR proteins and regulation of its expression may be crucial in cellular homeostasis., [RefSeq, PubMed]; These observations indicate that PS1D is the first eukaryotic ribosomal protein that is specific to higher eukaryotes., [RefSeq, PubMed]; We herein established a mouse model of MSC aging through pNO40-targeted depletion and demonstrated the effects of loss of pNO40 on bone homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0043489 RNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VD9-1", "uniprot_id": "NDUS1_MOUSE", "mass": 79777.0, "length": 727, "protein_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "gene_name": "Ndufs1", "organism": "Mouse", "refseq_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor", "refseq_ac": "NP_001153510", "gene_names_uniprotkb": "Ndufs1", "gene_names_refseq": "5830412M15Rik; 9930026A05Rik; Ndufs1", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; 7.1.1.2; CI-75kD; Complex I-75kD", "protein_names_refseq": "CI-75kD; NADH dehydrogenase (ubiquinone) Fe-S protein 1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; complex I-75kD", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 5 (Disease Ontology:DOID:0112068); inherited metabolic disorder (Disease Ontology:DOID:655); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:227197); (R-MMU-611105); (R-MMU-6799198); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "18299400;21183079;21750661;21952136;23576753;25428506;27799543;30084848;31219806;32072193;33300544;34418053;34428180;35820727;36288343;37453647;37507081;38575788;38697493;39627609;39927985", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:27799543, PubMed:32072193, PubMed:38575788). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:27799543). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:27799543)., [UniProtKB, PubMed, PubMed, PubMed]; Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQ73;Q8BM16", "ec_number_list": "2.1.1.-;1.-.-.-;3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;3.1.2.-;3.1.2.2;3.4.21.92;7.1.1.2;1.1.1.37;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;1.1.1.42;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;1.1.1.30;2.7.11.2;6.1.1.5;2.7.1.23;3.4.21.53;5.6.2.3;1.3.8.7;1.3.8.8;2.3.1.9;2.3.1.37;1.1.1.38;4.2.1.3;6.4.1.3;2.1.1.320;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;1.3.8.1;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0043209 myelin sheath;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q91VD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XU3-1", "uniprot_id": "NUCKS_MOUSE", "mass": 26313.0, "length": 234, "protein_name": "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1", "gene_name": "Nucks1", "organism": "Mouse", "refseq_name": "nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 2", "refseq_ac": "NP_001139276", "gene_names_uniprotkb": "Nucks1; Nucks", "gene_names_refseq": "2700010L10Rik; 8430423A01Rik; Nucks1; Nucks", "protein_names_uniprotkb": "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; JC7", "protein_names_refseq": "JC7; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 2; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; nuclear ubiquitous casein and cyclin-dependent kinases substrate; nuclear, casein kinase and cyclin-dependent kinase substrate", "tax_id": 10090, "disease": "", "pathway": " (mmu:98415)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15345747;16452087;17242355;18630941;19131326;21183079;21750661;27542204;28106169;28412246;34428180;34850570;35984892", "class_list": "", "function": "Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1., [UniProtKB, UniProtKB]; CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer., [RefSeq, PubMed]; In the context of Trp53 deficiency, wild type levels of Nucks1 are required to suppress radiation-induced thymic lymphoma, likely through the role of the NUCKS1 protein in the DNA damage response, [RefSeq, PubMed]; Study describes the role of NUCKS in corneal wound healing, inflammation and angiogenesis and links NUCKS to the activation of NF-kappa B and modulation of various cytokines. Publication Status: Online-Only, [RefSeq, PubMed]; This study demonstrates that depletion of NUCKS enhances the therapeutic efficacy of Bone marrow-derived mesenchymal stem cells for myocardial infarction via regulating the secretion of VEGFa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVD8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0044829 host-mediated activation of viral genome replication;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80XU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08553-1", "uniprot_id": "NFM_MOUSE", "mass": 95916.0, "length": 848, "protein_name": "Neurofilament medium polypeptide", "gene_name": "Nefm", "organism": "Mouse", "refseq_name": "neurofilament medium polypeptide", "refseq_ac": "NP_032717", "gene_names_uniprotkb": "Nefm; Nef3; Nfm", "gene_names_refseq": "NF-M; NF160; NF165; Nef3; Nefm; Nfm", "protein_names_uniprotkb": "Neurofilament medium polypeptide; 160 kDa neurofilament protein; NF-M; Neurofilament 3; Neurofilament triplet M protein", "protein_names_refseq": "160 kDa neurofilament protein; neurofilament 3, medium; neurofilament medium polypeptide; neurofilament protein M; neurofilament triplet M protein; neurofilament-M", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526)", "pathway": " (mmu:18040)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "15345747;16452087;16452088;17114649;18034455;19458039;19483694;21183079;21750661;22299025;22517741;22645316;22723690;22872234;24129315;25428506;28657654;28887429;3036526;3103856;32848054;33300544;34203471;34678516;35822049;40021952;40684658;40885482;8702840", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "A2VCT5;Q0VDM8;Q3HRJ6;Q3TNS4;Q3TPK2;Q61961;Q8BQ20", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005200 structural constituent of cytoskeleton;GO:0015643 toxic substance binding;GO:0044877 protein-containing complex binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0043204 perikaryon", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0008088 axo-dendritic transport;GO:0000226 microtubule cytoskeleton organization;GO:0060052 neurofilament cytoskeleton organization;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "P08553-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ48-1", "uniprot_id": "NUDC2_MOUSE", "mass": 17660.0, "length": 157, "protein_name": "NudC domain-containing protein 2", "gene_name": "Nudcd2", "organism": "Mouse", "refseq_name": "nudC domain-containing protein 2 isoform 2", "refseq_ac": "NP_001277626", "gene_names_uniprotkb": "Nudcd2; D11Ertd603e", "gene_names_refseq": "Nudcd2", "protein_names_uniprotkb": "NudC domain-containing protein 2", "protein_names_refseq": "nudC domain-containing protein 2 isoform 2; nudC domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52653)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17947660;21750661;29187734;35820727;39627609;40021952", "class_list": "", "function": "May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CD03;Q9CY63;Q9D0V4", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQ48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q7G0-1", "uniprot_id": "NUMA1_MOUSE", "mass": 235630.0, "length": 2094, "protein_name": "Nuclear mitotic apparatus protein 1", "gene_name": "Numa1", "organism": "Mouse", "refseq_name": "nuclear mitotic apparatus protein 1 isoform b", "refseq_ac": "NP_598708", "gene_names_uniprotkb": "Numa1", "gene_names_refseq": "6720401E04Rik; NuMA; Numa1", "protein_names_uniprotkb": "Nuclear mitotic apparatus protein 1; NuMA protein; Nuclear mitotic apparatus protein", "protein_names_refseq": "nuclear mitotic apparatus protein 1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:101706); (R-MMU-380320); (R-MMU-68875)", "pathway_count": 3, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18299400;19144319;19255246;21183079;21750661;21952136;22645316;23806337;24109598;25428506;25605945;25936915;26495903;26765568;26766442;28528544;31599954;32152506;32782141;34203471;34428180;35820727;36210013;36852467;39627609;40885482", "class_list": "", "function": "Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:19255246, PubMed:24109598, PubMed:26765568). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:26765568). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:24109598, PubMed:26765568). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation. Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (By similarity). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:26765568). Plays a role in mitotic MT aster assembly. Involved in anastral spindle assembly. Positively regulates TNKS protein localization to spindle poles in mitosis. Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (By similarity). Required for epidermal differentiation and hair follicle morphogenesis (PubMed:26765568)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y35", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0055028 cortical microtubule;GO:1905720 cytoplasmic microtubule bundle;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0055048 anastral spindle assembly;GO:1902365 positive regulation of protein localization to spindle pole body;GO:1902846 positive regulation of mitotic spindle elongation;GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "E9Q7G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64299-1", "uniprot_id": "CCN3_MOUSE", "mass": 38928.0, "length": 354, "protein_name": "CCN family member 3", "gene_name": "Ccn3", "organism": "Mouse", "refseq_name": "CCN family member 3 precursor", "refseq_ac": "NP_035060", "gene_names_uniprotkb": "Ccn3; Nov", "gene_names_refseq": "C130088N23Rik; Ccn3; Nov", "protein_names_uniprotkb": "CCN family member 3; Cellular communication network factor 3; Nephroblastoma-overexpressed gene protein homolog; NovH; Protein NOV homolog", "protein_names_refseq": "CCN family member 3 precursor; CCN family member 3; nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein homolog; novH; protein NOV homolog", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591)", "pathway": " (mmu:18133)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12050162;15213231;15611078;16294274;20139355;21063504;23653360;23705021;24722330;29287726;30899004;38987585;8622864;8975721", "class_list": "", "function": "A maternal brain hormone that builds bone., [RefSeq, PubMed]; CCN3 binds to the C terminus of Cx43 and has a role in mediating growth control induced by specific gap junction proteins, [RefSeq, PubMed]; Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (By similarity). Involved in bone regeneration as a negative regulator (PubMed:23653360). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (By similarity). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (PubMed:23705021). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (By similarity). Contributes to the control and coordination of inflammatory processes in atherosclerosis (PubMed:24722330). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (By similarity). Brain osteoanabolic hormone (PubMed:38987585). During lactation, maintains the maternal skeleton and viability of offspring (PubMed:38987585). In this context, may act on osteochondral skeletal stem cells (PubMed:38987585)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Study indicates that NOV is a positive modulator of chondrogenesis. Erratum:[J Bone Miner Res. 2006 Feb;21(2):352], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA67", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0005112 Notch binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0071603 endothelial cell-cell adhesion;GO:1904057 negative regulation of sensory perception of pain;GO:0090027 negative regulation of monocyte chemotaxis;GO:0001525 angiogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q64299-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ44-1", "uniprot_id": "NSF1C_MOUSE", "mass": 40710.0, "length": 370, "protein_name": "NSFL1 cofactor p47", "gene_name": "Nsfl1c", "organism": "Mouse", "refseq_name": "NSFL1 cofactor p47 isoform b", "refseq_ac": "NP_001278003", "gene_names_uniprotkb": "Nsfl1c", "gene_names_refseq": "Munc-18c; Nsfl1c; Stxbp3a; p47", "protein_names_uniprotkb": "NSFL1 cofactor p47; p97 cofactor p47", "protein_names_refseq": "NSFL1 cofactor p47 isoform b; NSFL1 cofactor p47; p97 cofactor p47", "tax_id": 10090, "disease": "", "pathway": " (mmu:386649); (R-MMU-9013407)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "14988733;17242355;17947660;18403597;19131326;21183079;21750661;23429921;27540115;34428180;35820727;36288343;37507081;38395304;39927985", "class_list": "", "function": "Data suggest that NADPH oxidase-derived cytosolic superoxide is increased in islets upon oleate exposure and leads to beta cell dysfunction; whole-body NADPH oxidase inhibition (via p47 knockout) decreases superoxide and restores islet function., [RefSeq, PubMed]; Genetic ablation of components of NADPH oxidase enhances susceptibility to the proinflammatory effects of CS leading to airspace enlargement and alveolar damage., [RefSeq, PubMed]; Munc18c accelerates SNARE-dependent membrane fusion in the presence of regulatory proteins alpha-SNAP and NSF., [RefSeq, PubMed]; Our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes., [RefSeq, PubMed]; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; That p47 ubiquitin regulatory X domain domains may act as general p97/valosin containing protein/CDC48 binding modules and that adaptor binding for N-ethylmaleimide sensitive factor and p97 might involve different binding sites, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AT03;Q80Y15;Q8BYL3", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0008289 lipid binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:1990730 VCP-NSFL1C complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005795 Golgi stack", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0000045 autophagosome assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061025 membrane fusion;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9CZ44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBY8-1", "uniprot_id": "NVL_MOUSE", "mass": 94476.0, "length": 855, "protein_name": "Nuclear valosin-containing protein-like", "gene_name": "Nvl", "organism": "Mouse", "refseq_name": "nuclear valosin-containing protein-like", "refseq_ac": "NP_080447", "gene_names_uniprotkb": "Nvl", "gene_names_refseq": "1200009I24Rik; Nvl", "protein_names_uniprotkb": "Nuclear valosin-containing protein-like; NVLp; Nuclear VCP-like protein", "protein_names_refseq": "nuclear valosin-containing protein-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:67459)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;19144319;21183079;21474449;23806337;30779550;31219806;34887587;39627609", "class_list": "", "function": "Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USC4;Q8BW27;Q8K2B5", "ec_number_list": "", "go_molecular_function": "GO:1990275 preribosome binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0032092 positive regulation of protein binding;GO:0042273 ribosomal large subunit biogenesis;GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:1905323 telomerase holoenzyme complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DBY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCN1-1", "uniprot_id": "NUD12_MOUSE", "mass": 51511.0, "length": 462, "protein_name": "NAD-capped RNA hydrolase NUDT12", "gene_name": "Nudt12", "organism": "Mouse", "refseq_name": "NAD-capped RNA hydrolase NUDT12 isoform 1", "refseq_ac": "NP_080773", "gene_names_uniprotkb": "Nudt12", "gene_names_refseq": "0610016O18Rik; Nudt12", "protein_names_uniprotkb": "NAD-capped RNA hydrolase NUDT12; 3.6.1.-; 3.6.1.22; DeNADding enzyme NUDT12; NADH pyrophosphatase NUDT12; Nucleoside diphosphate-linked moiety X motif 12; Nudix motif 12", "protein_names_refseq": "NAD-capped RNA hydrolase NUDT12 isoform 1; NAD-capped RNA hydrolase NUDT12; deNADding enzyme NUDT12; nucleoside diphosphate-linked moiety X motif 12; nudix (nucleoside diphosphate linked moiety X)-type motif 12; nudix (nucleoside diphosphnudix (nucleoside diphosphate linked moiety X)-type motif 12ate linked moiety X)-type motif 12; nudix motif 12; peroxisomal NADH pyrophosphatase NUDT12", "tax_id": 10090, "disease": "", "pathway": " (mmu:67993); (R-MMU-196807)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23806337;31101919;31875550;32432673;34105348;34428180", "class_list": "", "function": "Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs., [RefSeq, PubMed]; mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:32432673). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919). Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (By similarity). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (PubMed:31875550)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFA5", "ec_number_list": "3.6.1.22;3.6.1.18;3.6.1.-;2.7.7.2;3.1.-.-", "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0035529 NADH pyrophosphatase activity;GO:1990174 phosphodiesterase decapping endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006402 mRNA catabolic process;GO:0032922 circadian regulation of gene expression;GO:0006742 NADP+ catabolic process;GO:0110155 NAD-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DCN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHL0-1", "uniprot_id": "NTAL_MOUSE", "mass": 22876.0, "length": 203, "protein_name": "Linker for activation of T-cells family member 2", "gene_name": "Lat2", "organism": "Mouse", "refseq_name": "linker for activation of T-cells family member 2 isoform a", "refseq_ac": "NP_064428", "gene_names_uniprotkb": "Lat2; Lab; Ntal; Wbscr15; Wbscr5", "gene_names_refseq": "LAB; Lat2; NTAL; WSCR5; Wbscr15; Wbscr5", "protein_names_uniprotkb": "Linker for activation of T-cells family member 2; Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein homolog", "protein_names_refseq": "Williams-Beuren syndrome chromosome region 5 homolog; linker for activation of B-cells; linker for activation of T-cells family member 2 isoform a; membrane-associated adapter molecule; non-T cell activation linker; williams-Beuren syndrome chromosomal region 15 protein homolog", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:56743); (R-MMU-2730905)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11003705;11124535;12514734;15477348;15477350;15539154;15899851;16075062;17947660;19144319;21750661;24819605;25153696;30425164;32152506", "class_list": "", "function": "Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2., [UniProtKB, PubMed, PubMed, PubMed]; NTAL is a key inhibitor of mast cell chemotaxis toward PGE2, which may act through the RHOA/ERM/beta1-integrin and PI3K/AKT axes Publication Status: Online-Only, [RefSeq, PubMed]; NTAL is a negative regulator of FcepsilonRI activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations. Publication Status: Online-Only, [RefSeq, PubMed]; NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYF6;Q9JJ29", "ec_number_list": "", "go_molecular_function": "GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0035556 intracellular signal transduction;GO:0042113 B cell activation;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JHL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XZ2-1", "uniprot_id": "PCDB8_MOUSE", "mass": 84766.0, "length": 779, "protein_name": "Protocadherin beta-8", "gene_name": "Pcdhb8", "organism": "Mouse", "refseq_name": "protocadherin beta-8 precursor", "refseq_ac": "NP_444363", "gene_names_uniprotkb": "Pcdhb8", "gene_names_refseq": "Pcdhb5C; Pcdhb8; PcdhbH", "protein_names_uniprotkb": "Protocadherin beta-8; PCDH-beta-8", "protein_names_refseq": "PCDH-beta-8; protocadherin beta-8 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:93879)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11230163;21750661;27161523", "class_list": "", "function": "Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91XZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2EMV9-1", "uniprot_id": "PAR14_MOUSE", "mass": 203802.0, "length": 1817, "protein_name": "Protein mono-ADP-ribosyltransferase PARP14", "gene_name": "Parp14", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP14", "refseq_ac": "NP_001034619", "gene_names_uniprotkb": "Parp14; Kiaa1268", "gene_names_refseq": "1600029O10Rik; ARTD8; CoaSt6; Parp14; mKIAA1268", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP14; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; CoaSt6; Collaborator of STAT6; PARP-14; Poly [ADP-ribose] polymerase 14", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 8; PARP-14; collaborator of STAT6; poly [ADP-ribose] polymerase 14; protein mono-ADP-ribosyltransferase PARP14", "tax_id": 10090, "disease": "", "pathway": " (mmu:547253)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;16537510;17478423;18069692;19147789;22872234;26495903;26740625;27796300;29858569;31219806;33317392;34428180;35820727;38612413;38967223", "class_list": "", "function": "ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis., [RefSeq, PubMed]; Data show that Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood., [RefSeq, PubMed]; PARP enzymatic activity is associated with CoaSt6, and this function of CoaSt6 can append ADP-ribose to itself and p100, [RefSeq, PubMed]; PARP-14 mediates regulation of gene expression and lymphocyte physiology by IL-4 and has a function distinct from PARP-1., [RefSeq, PubMed]; PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery., [RefSeq, PubMed]; Stat6 binds to collaborator of Stat6 (CoaSt6), a protein that lacks conventional coactivator motifs but contains three iterations of a domain found in the variant histone macroH2A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QP48;Q571C6;Q8BN35;Q8VDT6", "ec_number_list": "2.4.2.-;2.4.2.30", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity;GO:0070403 NAD+ binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0045087 innate immune response;GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q2EMV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFF0-1", "uniprot_id": "PAR11_MOUSE", "mass": 38737.0, "length": 331, "protein_name": "Protein mono-ADP-ribosyltransferase PARP11", "gene_name": "Parp11", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP11 isoform 2", "refseq_ac": "NP_001333441", "gene_names_uniprotkb": "Parp11", "gene_names_refseq": "5330431N24Rik; ARTD11; HIN1L; PARP-11; Parp11", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP11; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 11; ARTD11; PARP-11; Poly [ADP-ribose] polymerase 11", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 11; poly [ADP-ribose] polymerase 11; protein mono-ADP-ribosyltransferase PARP11 isoform 2; protein mono-ADP-ribosyltransferase PARP11", "tax_id": 10090, "disease": "", "pathway": " (mmu:101187)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25673562;30988430", "class_list": "", "function": "Findings suggest that PARP11 is involved in regulating the IFN-I signaling pathway and antiviral efficacy by targeting beta-TrCP and degrading IFNAR1., [RefSeq, PubMed]; Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (By similarity). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (PubMed:25673562). Inhibits the type I interferon activated signaling pathway (By similarity). Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation (By similarity)., [UniProtKB, PubMed, UniProtKB]; PARP11 is a novel enzyme important for proper sperm head shaping and identifies it as a potential factor involved in idiopathic mammalian teratozoospermia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAF2;Q3UZR7", "ec_number_list": "2.4.2.-;2.4.2.30;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity;GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0007283 spermatogenesis;GO:0015031 protein transport;GO:0030154 cell differentiation;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CFF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBJ1-1", "uniprot_id": "PGAM1_MOUSE", "mass": 28832.0, "length": 254, "protein_name": "Phosphoglycerate mutase 1", "gene_name": "Pgam1", "organism": "Mouse", "refseq_name": "phosphoglycerate mutase 1", "refseq_ac": "NP_075907", "gene_names_uniprotkb": "Pgam1", "gene_names_refseq": "2310050F24Rik; Pgam-1; Pgam1", "protein_names_uniprotkb": "Phosphoglycerate mutase 1; 5.4.2.11; 5.4.2.4; BPG-dependent PGAM 1; PGAM-B; Phosphoglycerate mutase isozyme B", "protein_names_refseq": "BPG-dependent PGAM 1; PGAM-B; phosphoglycerate mutase 1; phosphoglycerate mutase isozyme B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18648); (R-MMU-6798695); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17947660;18034455;21183079;22645316;23806337;26740625;33725478;33914812;34428180;35984892;36288343;37453647;37507081", "class_list": "", "function": "Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate., [UniProtKB, UniProtKB]; Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6W0;Q9ERT3", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;5.4.2.11;5.4.2.4;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043209 myelin sheath", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0061621 canonical glycolysis;GO:0046166 glyceraldehyde-3-phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9DBJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17918-1", "uniprot_id": "PCNA_MOUSE", "mass": 28785.0, "length": 261, "protein_name": "DNA sliding clamp PCNA", "gene_name": "Pcna", "organism": "Mouse", "refseq_name": "DNA sliding clamp PCNA", "refseq_ac": "NP_035175", "gene_names_uniprotkb": "Pcna", "gene_names_refseq": "Pcna", "protein_names_uniprotkb": "DNA sliding clamp PCNA; Cyclin; PCNA; Proliferating cell nuclear antigen", "protein_names_refseq": "DNA sliding clamp PCNA; cyclin", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); ataxia-telangiectasia-like disorder 2 (Disease Ontology:DOID:0081385); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); leiomyoma (Disease Ontology:DOID:127); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cancer (Disease Ontology:DOID:3571); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18538); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174437); (R-MMU-4615885); (R-MMU-5358565); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6804114); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183); (R-MMU-8866654)", "pathway_count": 25, "publication_count": 23, "publication_id_list": "12573260;16075224;1674997;16857592;17115032;1726365;18299400;19224205;20173027;23201573;24115439;25428506;25605945;2906640;30084848;30779550;31219806;34203471;34428180;35628489;35820727;39627609;9371605", "class_list": "", "function": "Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0032139 dinucleotide insertion or deletion binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0043626 PCNA complex;GO:0070557 PCNA-p21 complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006287 base-excision repair, gap-filling;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P17918-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ61-1", "uniprot_id": "PESC_MOUSE", "mass": 67796.0, "length": 584, "protein_name": "Pescadillo homolog", "gene_name": "Pes1", "organism": "Mouse", "refseq_name": "pescadillo homolog", "refseq_ac": "NP_075027", "gene_names_uniprotkb": "Pes1; PES1; Pes", "gene_names_refseq": "Pes1", "protein_names_uniprotkb": "Pescadillo homolog", "protein_names_refseq": "pescadillo homolog 1, containing BRCT domain; pescadillo homolog", "tax_id": 10090, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (mmu:64934); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11071894;11112348;12237316;15169904;15225545;17308336;21750661;25557119;29187734;31106266;31219806;34428180;34887587;36210013;36775058;39627609", "class_list": "", "function": "Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, PubMed, HAMAP, PubMed, UniProtKB, UniProtKB]; Data show that pescadillo associates with several structures that are associated with nucleogenesis, and that loss of function results in embryonic lethality due to disrupted ribosome biosynthesis., [RefSeq, PubMed]; Effects of PES1 and UBF1 expression on the growth and differentiation of cell lines derived from 32D cells, an interleukin-3 (IL-3)-dependent murine myeloid cell line, [RefSeq, PubMed]; Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy., [RefSeq, PubMed]; PES1 facilitates telomerase assembly by promoting direct interaction between TERT and TR without affecting TERT and TR levels Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that PES1 is a marker of neuroblastoma outcome, that it regulates neuroblastoma cell proliferation, and is associated with neuroblastoma differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542F0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0007000 nucleolus organization;GO:0008283 cell population proliferation;GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9EQ61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2TJ95-1", "uniprot_id": "RSPO3_MOUSE", "mass": 31454.0, "length": 277, "protein_name": "R-spondin-3", "gene_name": "Rspo3", "organism": "Mouse", "refseq_name": "R-spondin-3 precursor", "refseq_ac": "NP_082627", "gene_names_uniprotkb": "Rspo3", "gene_names_refseq": "2810459H04Rik; Cristin1; Rspo3; Thsd2", "protein_names_uniprotkb": "R-spondin-3; Cabriolet; Cristin-1; Cysteine-rich and single thrombospondin domain-containing protein 1; Nucleopondin; Roof plate-specific spondin-3", "protein_names_refseq": "R-spondin 3 homolog; R-spondin-3 precursor; cabriolet; cristin 1; cysteine-rich and single thrombospondin domain-containing protein 1; nucleopondin; roof plate-specific spondin-3; thrombospondin, type I, domain 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72780); (R-MMU-4641263)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15469841;16543246;16963017;21693646;21750661;26766444", "class_list": "", "function": "Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:16543246, PubMed:21693646). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (PubMed:16543246, PubMed:21693646, PubMed:26766444). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Suggest a critical role for Rspo3 in the interaction between chorion and allantois in labyrinthine development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6M4;Q3SYI9;Q5R2V4;Q8BVW2;Q9CSB2", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0001974 blood vessel remodeling;GO:0016055 Wnt signaling pathway;GO:0060173 limb development;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2TJ95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97351-1", "uniprot_id": "RS3A_MOUSE", "mass": 29885.0, "length": 264, "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "Rps3a", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS1", "refseq_ac": "NP_058655", "gene_names_uniprotkb": "Rps3a; Rps3a1", "gene_names_refseq": "Rps3a1; Rps3a", "protein_names_uniprotkb": "Small ribosomal subunit protein eS1; 40S ribosomal protein S3a; Protein TU-11", "protein_names_refseq": "40S ribosomal protein S3a; ribosomal protein S3A; small ribosomal subunit protein eS1", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:20091); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 26, "publication_id_list": "10713066;11823430;17242355;17947660;21183079;22645316;23806337;25605945;26495903;31361958;31956894;33300544;33649389;33725478;34428180;35820727;35984892;36288343;36517592;37453647;37507081;37828378;39627609;39927985;9074506;9573378", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (PubMed:10713066)., [UniProtKB, HAMAP, UniProtKB, PubMed, PubMed]; This dysregulation is also seen in AdarDelta2-13; Mavs-/- but not in AdarE861A/E861A; Ifih1-/- mice, suggesting editing-independent functions of ADAR in regulating expression levels of Rps3a1 and Rps3a3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P97351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0T0-1", "uniprot_id": "RTN1_MOUSE", "mass": 83572.0, "length": 780, "protein_name": "Reticulon-1", "gene_name": "Rtn1", "organism": "Mouse", "refseq_name": "reticulon-1 isoform A2", "refseq_ac": "NP_001273377", "gene_names_uniprotkb": "Rtn1; Nsp", "gene_names_refseq": "Nsp; Rtn1", "protein_names_uniprotkb": "Reticulon-1; Neuroendocrine-specific protein", "protein_names_refseq": "neuroendocrine-specific protein; reticulon-1 isoform A2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:104001)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;12036513;12832288;21183079;21750661;22645316;25428506;31599954;32848054;33300544;35822049;37228035;40885482", "class_list": "", "function": "Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4S4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:1902430 negative regulation of amyloid-beta formation;GO:0007420 brain development;GO:0030182 neuron differentiation;GO:0071787 endoplasmic reticulum tubular network formation;GO:1990809 endoplasmic reticulum tubular network membrane organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8K0T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFI0-1", "uniprot_id": "NED4L_MOUSE", "mass": 115419.0, "length": 1004, "protein_name": "E3 ubiquitin-protein ligase NEDD4-like", "gene_name": "Nedd4l", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nedd4l; Kiaa0439; Nedd4b", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEDD4-like; 2.3.2.26; 2.3.2.36; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); Liddle syndrome (Disease Ontology:DOID:0050477); stroke (Disease Ontology:DOID:0051061)", "pathway": " (mmu:83814); (R-MMU-2173795); (R-MMU-2672351); (R-MMU-983168)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "11149908;11244092;11742982;12050153;12424229;14993279;15123669;15958725;17242355;21183079;21750661;22645316;27694961;30084848;32782141;32848054;33300544;34428180;34678516;37828378;39627609;40885482", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:15123669). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes (By similarity). Involved in the regulation of TOR signaling (By similarity). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF. Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (By similarity). Ubiquitinates TTYH2 and TYYH3 and regulates protein levels of TTYH2 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRT9;Q8BS42;Q99PK2", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0019871 sodium channel inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016324 apical plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:2001288 positive regulation of caveolin-mediated endocytosis;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1903861 positive regulation of dendrite extension;GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8CFI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00288-1", "uniprot_id": "PAX8_MOUSE", "mass": 48793.0, "length": 457, "protein_name": "Paired box protein Pax-8", "gene_name": "Pax8", "organism": "Mouse", "refseq_name": "paired box protein Pax-8", "refseq_ac": "NP_035170", "gene_names_uniprotkb": "Pax8; Pax-8", "gene_names_refseq": "Pax-8; Pax8", "protein_names_uniprotkb": "Paired box protein Pax-8", "protein_names_refseq": "paired box gene 8; paired box protein Pax-8", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nongoitrous hypothyroidism 2 (Disease Ontology:DOID:0070124)", "pathway": " (mmu:18510)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1516825;1723950;21183079;21750661;9205117", "class_list": "", "function": "This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]., [RefSeq]; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97342;Q6GU20", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:2000612 regulation of thyroid-stimulating hormone secretion;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0039003 pronephric field specification;GO:0072289 metanephric nephron tubule formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q00288-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YXG0-1", "uniprot_id": "HMCN1_MOUSE", "mass": 611561.0, "length": 5634, "protein_name": "Hemicentin-1", "gene_name": "Hmcn1", "organism": "Mouse", "refseq_name": "hemicentin-1 precursor", "refseq_ac": "NP_001019891", "gene_names_uniprotkb": "Hmcn1", "gene_names_refseq": "EG545370; FIBL-6; Gm201; Hmcn1", "protein_names_uniprotkb": "Hemicentin-1; FIBL-6; Fibulin-6", "protein_names_refseq": "fibulin-6; hemicentin-1 precursor", "tax_id": 10090, "disease": "age related macular degeneration 1 (Disease Ontology:DOID:0110014)", "pathway": " (mmu:545370)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17015624;21215633;21750661;24951538;25428506;29488390;30779550;32035013;34203471;34418053;34428180;34504132;35984892", "class_list": "", "function": "Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes (By similarity). Plays a role in basement membrane organization (PubMed:34504132). May promote cleavage furrow maturation during cytokinesis in preimplantation embryos (PubMed:21215633). May play a role in the architecture of adhesive and flexible epithelial cell junctions (PubMed:17015624). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (PubMed:24951538)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; This study showed that extracellular hemicentin-1[Hmcn1] assemble at the cleavage furrow of dividing cells in the C. elegans germline and in preimplantation mouse embryos., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "D3Z2Q7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005938 cell cortex", "go_biological_process": "GO:0051301 cell division;GO:0009617 response to bacterium;GO:0030036 actin cytoskeleton organization;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "D3YXG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22361-1", "uniprot_id": "HNF1A_MOUSE", "mass": 67253.0, "length": 628, "protein_name": "Hepatocyte nuclear factor 1-alpha", "gene_name": "Hnf1a", "organism": "Mouse", "refseq_name": "hepatocyte nuclear factor 1-alpha", "refseq_ac": "NP_033353", "gene_names_uniprotkb": "Hnf1a; Hnf-1a; Hnf-1; Tcf1", "gene_names_refseq": "HNF1-alpha; HNF1[a]; HNF1; Hnf-1; Hnf1alpha; Hnf1a; LFB1; Tcf-1; Tcf1", "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-alpha; HNF-1-alpha; HNF-1A; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1", "protein_names_refseq": "hepatocyte nuclear factor 1-alpha; liver-specific transcription factor LF-B1; transcription factor 1", "tax_id": 10090, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); hepatocellular adenoma (Disease Ontology:DOID:0050868); type 1 diabetes mellitus 20 (Disease Ontology:DOID:0110757); maturity-onset diabetes of the young type 3 (Disease Ontology:DOID:0111102); familial hepatic adenoma (Disease Ontology:DOID:0111366); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); gestational diabetes (Disease Ontology:DOID:11714); extrahepatic cholestasis (Disease Ontology:DOID:13619); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); renal cell carcinoma (Disease Ontology:DOID:4450); chromophobe renal cell carcinoma (Disease Ontology:DOID:4471); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); phenylketonuria (Disease Ontology:DOID:9281); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:21405)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10966642;11106484;11439029;1354855;18630941;19289501;21183079;21750661;2263635;30555544;37730861;38825059;38959885;40997131;9566924", "class_list": "", "function": "An Italian MODY family with proband and son carrying variants in GCK and HFN1A: is it a true case of digenic MODY?, [RefSeq, PubMed]; Pan-cancer mapping of single CD8[+] T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity., [RefSeq, PubMed]; The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop., [RefSeq, PubMed]; This gene encodes a hepatic transcription factor. The encoded protein is not a member of the T-cell factor family, and is distinct from T-cell specific transcription factor 7 which has also been referred to by the symbol Tcf1. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (PubMed:19289501). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QP86", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0035623 renal D-glucose absorption;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:1903799 negative regulation of miRNA processing;GO:2001171 positive regulation of ATP biosynthetic process;GO:0048341 paraxial mesoderm formation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P22361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "S4R1M9-1", "uniprot_id": "OSB10_MOUSE", "mass": 83856.0, "length": 766, "protein_name": "Oxysterol-binding protein-related protein 10", "gene_name": "Osbpl10", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 10", "refseq_ac": "NP_683761", "gene_names_uniprotkb": "Osbpl10; Orp10", "gene_names_refseq": "4933433D06Rik; C820004B04Rik; OPR-10; ORP-10; Osbpl10", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 10; ORP-10; OSBP-related protein 10", "protein_names_refseq": "OSBP-related protein 10; oxysterol-binding protein-related protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:74486); (R-MMU-1482801)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22645316", "class_list": "", "function": "Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2T7", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0001786 phosphatidylserine binding;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006649 phospholipid transfer to membrane;GO:0055091 phospholipid homeostasis;GO:0097212 lysosomal membrane organization;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "S4R1M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0N6-1", "uniprot_id": "HOT_MOUSE", "mass": 49937.0, "length": 465, "protein_name": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial", "gene_name": "Adhfe1", "organism": "Mouse", "refseq_name": "hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 1", "refseq_ac": "NP_780445", "gene_names_uniprotkb": "Adhfe1", "gene_names_refseq": "6330565B14Rik; Adh8; Adhfe1; HOT", "protein_names_uniprotkb": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial; 1.1.99.24; ADHFe1; Alcohol dehydrogenase iron-containing protein 1; HOT", "protein_names_refseq": "Fe-containing alcohol dehydrogenase 1; alcohol dehydrogenase 8; alcohol dehydrogenase iron-containing protein 1; hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 1; hydroxyacid-oxoacid transhydrogenase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:76187); (R-MMU-880009)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17559793;21183079;21750661;23576753;34428180", "class_list": "", "function": "Adhfe1 is a novel alcohol dehydrogenase with mitochondrial localization, [RefSeq, PubMed]; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q78SV3;Q8BYP0", "ec_number_list": "1.1.99.24", "go_molecular_function": "GO:0047988 hydroxyacid-oxoacid transhydrogenase activity;GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0046952 ketone body catabolic process;GO:0019552 L-glutamate catabolic process via 2-hydroxyglutarate", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R0N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78ZA7-1", "uniprot_id": "NP1L4_MOUSE", "mass": 42679.0, "length": 375, "protein_name": "Nucleosome assembly protein 1-like 4", "gene_name": "Nap1l4", "organism": "Mouse", "refseq_name": "nucleosome assembly protein 1-like 4 isoform a", "refseq_ac": "NP_001272418", "gene_names_uniprotkb": "Nap1l4", "gene_names_refseq": "2810410H14Rik; D7Wsu30e; Nap1l4; Nap2", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 4; Histone chaperone NAP1L4", "protein_names_refseq": "histone chaperone NAP1L4; nucleosome assembly protein 1-like 4 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:17955)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11063728;17242355;17499049;19131326;21183079;21333655;21750661;23550035;23806337;28366643;33300544;34076483;34428180;36288343;37828378;9618174", "class_list": "", "function": "Acts as a histone chaperone in nucleosome assembly (PubMed:28366643). In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AB1 and H2BC1/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells (PubMed:28366643)., [UniProtKB, PubMed]; Leukocyte migration is initiated by homotypic adhesive interactions between platelets, leading to the development of an NAP-2 chemotactic gradient within the thrombus body that guides leukocytes to sites of vascular injury., [RefSeq, PubMed]; NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88701", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q78ZA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88338-1", "uniprot_id": "CAD16_MOUSE", "mass": 89860.0, "length": 830, "protein_name": "Cadherin-16", "gene_name": "Cdh16", "organism": "Mouse", "refseq_name": "cadherin-16 isoform 1 precursor", "refseq_ac": "NP_031689", "gene_names_uniprotkb": "Cdh16", "gene_names_refseq": "Cdh16", "protein_names_uniprotkb": "Cadherin-16; Kidney-specific cadherin; Ksp-cadherin", "protein_names_refseq": "KSP-cadherin; cadherin-16 isoform 1 precursor; kidney-specific cadherin", "tax_id": 10090, "disease": "thyroid cancer (Disease Ontology:DOID:1781)", "pathway": " (mmu:12556)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10516284;21183079;21750661;39145457;9721215", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 8489, "biomarker_type": "", "glycan_count": 52, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLZ5", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045202 synapse;GO:0016020 membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "O88338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8WTY4-1", "uniprot_id": "CPIN1_MOUSE", "mass": 33429.0, "length": 309, "protein_name": "Anamorsin", "gene_name": "Ciapin1", "organism": "Mouse", "refseq_name": "anamorsin", "refseq_ac": "NP_598902", "gene_names_uniprotkb": "Ciapin1", "gene_names_refseq": "2810413N20Rik; Ciapin1; anamorsin", "protein_names_uniprotkb": "Anamorsin; Cytokine-induced apoptosis inhibitor 1; Fe-S cluster assembly protein DRE2 homolog", "protein_names_refseq": "anamorsin; fe-S cluster assembly protein DRE2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:109006)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14970183;16957168;21183079;21219862;21540332;21750661;22645316;24440520;24973211;25153642;25428506;28528544;30818058;31582212", "class_list": "", "function": "AM was essential for both autonomous and extrinsic regulation of fetal liver hematopoiesis. This study provided new insight into the molecular regulation of hematopoiesis., [RefSeq, PubMed]; Among 46 putative substrates identified in MN9D neuronal cells, we further evaluated whether caspase-3-mediated cleavage of anamorsin, a recently recognized cell death-defying factor in hematopoiesis, is a general feature of apoptosis., [RefSeq, PubMed]; Anamorsin exerts a neuroprotective effect by reducing intracellular ROS levels and subsequently attenuating activated stress-activated MAP kinases pathways, [RefSeq, PubMed]; Anamorsin is considered to be a necessary molecule for hematopoiesis that mediates antiapoptotic effects of various cytokines., [RefSeq, PubMed]; CIAPIN1 was localized in both the cytoplasm and the nucleus and was accumulated in the nucleolus. Bioinformatic prediction disclosed a putative nuclear localization signal and a putative nuclear export signal within mouse CIAPIN1., [RefSeq, PubMed]; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (PubMed:14970183)., [UniProtKB, PubMed, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Tat-CIAPIN1 protein transduced into HT-22cells and significantly inhibited cell death, DNA fragmentation, and reactive oxygen species (ROS) generation., [RefSeq, PubMed]; These data suggest that PKCtheta;, PKCdelta, and p38MAPK activation lead to cell cycle retardation in AM KO MEF cells, and that AM may negatively regulate novel PKCs and p38MAPK in MEF cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJW5;Q8VC24;Q91W83", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0009055 electron transfer activity;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8WTY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2Y3-1", "uniprot_id": "HOME1_MOUSE", "mass": 41413.0, "length": 366, "protein_name": "Homer protein homolog 1", "gene_name": "Homer1", "organism": "Mouse", "refseq_name": "homer protein homolog 1 isoform b", "refseq_ac": "NP_001271118", "gene_names_uniprotkb": "Homer1; Vesl1", "gene_names_refseq": "Homer1; PSD-Zip45; SYN47; Ves-1; homer-1; vesl-1", "protein_names_uniprotkb": "Homer protein homolog 1; Homer-1; VASP/Ena-related gene up-regulated during seizure and LTP 1; Vesl-1", "protein_names_refseq": "VASP/Ena-related gene up-regulated during seizure and LTP 1; homer homolog 1; homer protein homolog 1 isoform b; homer protein homolog 1; homer, neuronal immediate early gene, 1; immediate early gene protein Homer1A", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:26556); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10851183;12176012;12379179;17107665;21183079;21558424;21750661;22645316;24153177;25979765;27373832;33300544;40885482;9808458;9808459", "class_list": "", "function": "Molecular cloning of Homer1d, an alternativly splice isoform, that controls trafficking of group I metabotropic glutamate receptor, [RefSeq, PubMed]; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3E1;Q8K4M8;Q9Z0E9;Q9Z216", "ec_number_list": "", "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0031802 type 5 metabotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:0003009 skeletal muscle contraction;GO:0007613 memory;GO:0051262 protein tetramerization;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z2Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11103-1", "uniprot_id": "PARP1_MOUSE", "mass": 113100.0, "length": 1013, "protein_name": "Poly [ADP-ribose] polymerase 1", "gene_name": "Parp1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Parp1; Adprp; Adprt1; Adprt", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase 1; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; PARP-1; Poly [ADP-ribose] polymerase 1, 24-kDa form; Poly [ADP-ribose] polymerase 1, 89-kDa form; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; msPARP", "protein_names_refseq": "", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); nephritis (Disease Ontology:DOID:10952); leiomyoma (Disease Ontology:DOID:127); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); middle cerebral artery infarction (Disease Ontology:DOID:3525); autoimmune disease (Disease Ontology:DOID:417); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199); stomach carcinoma (Disease Ontology:DOID:5517); congestive heart failure (Disease Ontology:DOID:6000); arthritis (Disease Ontology:DOID:848); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-MMU-110362); (R-MMU-2173795); (R-MMU-3108214); (R-MMU-5685939); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696400)", "pathway_count": 7, "publication_count": 33, "publication_id_list": "10809783;11948190;12114629;12727891;14623329;16464859;17116882;17320046;19779455;21467298;21577210;21680843;21750661;22464733;22645316;23806337;2498841;25428506;25605945;25936915;28991266;30084848;30779550;31219806;31599954;32822587;34428180;34798058;35460603;36210013;39627609;7578427;9642267", "class_list": "", "function": "Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:21680843). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:32822587). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (By similarity). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (By similarity). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (PubMed:32822587). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (By similarity). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (By similarity). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (By similarity). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR and NFAT5 (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (By similarity). Required for PARP9 and DTX3L recruitment to DNA damage sites (By similarity). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (PubMed:34798058). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:32822587, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (By similarity). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (By similarity). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (By similarity). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (By similarity). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (PubMed:12114629, PubMed:17116882, PubMed:21467298). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (PubMed:32822587). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Plays a role in sister chromatid cohesion by mediating ADP-ribosylation of RSMC during S phase which promotes the interaction between RSMC and CDCA5/sororin, leading to enhanced interaction of CDCA5/sororin with the cohesin complex and promotion of sister chromatid cohesion (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Promotes AIFM1-mediated apoptosis. This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis., [UniProtKB, UniProtKB]; This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLX4;Q9QVQ3", "ec_number_list": "2.4.2.-;5.6.2.3;2.3.2.-;2.4.2.30;3.2.1.143;2.3.2.27;3.1.11.2;3.1.21.-;3.1.-.-;5.6.2.4;2.7.7.7;3.1.11.-;1.14.11.-;2.3.2.23;2.3.2.32;3.6.-.-;2.7.11.22;2.7.11.23;2.7.11.24;4.2.99.18;4.2.99.-;3.6.4.-", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1904762 positive regulation of myofibroblast differentiation;GO:1990166 protein localization to site of double-strand break;GO:0016051 carbohydrate biosynthetic process;GO:0032700 negative regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P11103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CAE2-1", "uniprot_id": "HENMT_MOUSE", "mass": 44921.0, "length": 395, "protein_name": "Small RNA 2'-O-methyltransferase", "gene_name": "Henmt1", "organism": "Mouse", "refseq_name": "small RNA 2'-O-methyltransferase", "refseq_ac": "NP_001072114", "gene_names_uniprotkb": "Henmt1; 4921515J06Rik", "gene_names_refseq": "4921515J06Rik; Hen1; Henmt1; mHEN1", "protein_names_uniprotkb": "Small RNA 2'-O-methyltransferase; 2.1.1.386; HEN1 methyltransferase homolog 1; mHEN1", "protein_names_refseq": "small RNA 2'-O-methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66715)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17652135;18029764;21750661;26496356;29703750;34590701", "class_list": "", "function": "DNA damage and a catastrophic deregulation of the haploid germ cell gene expression. Collectively these results define a critical role for HENMT1 and piRNAs in the maintenance of TE repression in adult germ cells and setting the spermatogenic program. Erratum:[PLoS Genet. 2015 Dec 29;11(12):e1005782. doi: 10.1371/journal.pgen.1005782. PMID: 26714033] Publication Status: Online-Only, [RefSeq, PubMed]; HENMT1 is involved in the maintenance of normal female fertility in the mouse., [RefSeq, PubMed]; Methylation substrates in mouse spermatogonial stem cells and the substrate-recognition mechanism of mammalian Hen1, [RefSeq, PubMed]; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VCS5;Q8C3K8", "ec_number_list": "3.6.4.13;2.1.1.386;3.1.26.-;5.6.2.5", "go_molecular_function": "GO:0090486 small RNA 2'-O-methyltransferase activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0008171 O-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043186 P granule", "go_biological_process": "GO:0030422 siRNA processing;GO:0034587 piRNA processing;GO:0001510 RNA methylation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CAE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCZ9-1", "uniprot_id": "HYPDH_MOUSE", "mass": 50723.0, "length": 456, "protein_name": "Hydroxyproline dehydrogenase", "gene_name": "Prodh2", "organism": "Mouse", "refseq_name": "hydroxyproline dehydrogenase isoform 1", "refseq_ac": "NP_062419", "gene_names_uniprotkb": "Prodh2; Hypdh", "gene_names_refseq": "2510028N04Rik; 2510038B11Rik; HYPDH; MmPOX1; MmPOX; POX1; Prodh2", "protein_names_uniprotkb": "Hydroxyproline dehydrogenase; 1.5.5.2; 1.5.5.3; HYPDH; Kidney and liver proline oxidase 1; MmPOX1; PO; Probable proline dehydrogenase 2; Probable proline oxidase 2; Proline oxidase-like protein; Proline oxidase", "protein_names_refseq": "PO; hydroxyproline dehydrogenase isoform 1; hydroxyproline dehydrogenase; kidney and liver proline oxidase 1; probable proline dehydrogenase 2; probable proline oxidase 2; proline oxidase 1; proline oxidase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56189); (R-MMU-389661); (R-MMU-70688)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15581617;21750661;23576753;24096872;25428506;26655602;34428180", "class_list": "", "function": "Converts proline to delta-1-pyrroline-5-carboxylate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Decreasing hepatic glycolate oxidase and HYPDH expression decreases oxalate excretion., [RefSeq, PubMed]; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis., [UniProtKB, UniProtKB]; Study revealed that the expression of PO and PDH was regulated by HNF1alpha and HNF4alpha, [RefSeq, PubMed]; The nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2V058;Q9QX62", "ec_number_list": "1.5.5.3;1.5.5.2", "go_molecular_function": "GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors;GO:0071949 FAD binding;GO:0004657 proline dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate;GO:0006562 L-proline catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VCZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61290-1", "uniprot_id": "CAC1E_MOUSE", "mass": 257236.0, "length": 2272, "protein_name": "Voltage-dependent R-type calcium channel subunit alpha-1E", "gene_name": "Cacna1e", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cacna1e; Cach6; Cacnl1a6; Cchra1", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent R-type calcium channel subunit alpha-1E; BII; Brain calcium channel II; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3", "protein_names_refseq": "", "tax_id": 10090, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); developmental and epileptic encephalopathy 69 (Disease Ontology:DOID:0112205); epilepsy (Disease Ontology:DOID:1826); migraine (Disease Ontology:DOID:6364)", "pathway": " (mmu:12290); (R-MMU-112308); (R-MMU-422356)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21183079;21750661;24129315;31219806;33300544;34428180;35820727;8071363", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity;GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007626 locomotory behavior;GO:0008542 visual learning;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61290-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UCV8-1", "uniprot_id": "OTUL_MOUSE", "mass": 40320.0, "length": 352, "protein_name": "Ubiquitin thioesterase otulin", "gene_name": "Otulin", "organism": "Mouse", "refseq_name": "ubiquitin thioesterase otulin isoform 1", "refseq_ac": "NP_001013814", "gene_names_uniprotkb": "Otulin; Fam105b; Gum", "gene_names_refseq": "Fam105b; Otulin; m3Sapc; m7-1Sapc", "protein_names_uniprotkb": "Ubiquitin thioesterase otulin; 3.4.19.12; Deubiquitinating enzyme otulin; OTU domain-containing deubiquitinase with linear linkage specificity; Ubiquitin thioesterase Gumby", "protein_names_refseq": "OTU domain-containing deubiquitinase with linear linkage specificity; deubiquitinating enzyme otulin; family with sequence similarity 105, member B; gumby; protein FAM105B; ubiquitin thioesterase Gumby; ubiquitin thioesterase otulin isoform 1; ubiquitin thioesterase otulin", "tax_id": 10090, "disease": "immunodeficiency 107 (Disease Ontology:DOID:0061076); autosomal dominant autoinflammation, panniculitis, and dermatosis syndrome (Disease Ontology:DOID:0061169); autosomal recessive autoinflammation, panniculitis, and dermatosis syndrome (Disease Ontology:DOID:0080163)", "pathway": " (mmu:432940); (R-MMU-5357905); (R-MMU-8866652)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;23708998;27523608;29950720;34428180;37598207;38827742", "class_list": "", "function": "Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:27523608, PubMed:29950720). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (By similarity). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:29950720). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608, PubMed:29950720). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; OTULIN haploinsufficiency predisposes to environmentally directed inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection. Publication Status: Online-Only, [RefSeq, PubMed]; Two distinct mutations in the (uro)chordate-specific gumby (also called Fam105b) gene cause an embryonic angiogenic phenotype in gumby mice, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY59;Q5M8N1;Q8R027", "ec_number_list": "3.4.19.12;2.3.2.31", "go_molecular_function": "GO:0008234 cysteine-type peptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0050728 negative regulation of inflammatory response;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UCV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJ76-1", "uniprot_id": "HMCN2_MOUSE", "mass": 547198.0, "length": 5100, "protein_name": "Hemicentin-2", "gene_name": "Hmcn2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Hmcn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Hemicentin-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "17015624;21215633;21750661;24129315;25428506;32035013;34418053;34504132", "class_list": "", "function": "", "predicted_glycosites": 43, "predicted_n_glycosites": 40, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 44, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNH3", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030054 cell junction;GO:0030424 axon", "go_biological_process": "GO:0050808 synapse organization;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2AJ76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R060-1", "uniprot_id": "NUBP1_MOUSE", "mass": 34085.0, "length": 320, "protein_name": "Cytosolic Fe-S cluster assembly factor NUBP1", "gene_name": "Nubp1", "organism": "Mouse", "refseq_name": "cytosolic Fe-S cluster assembly factor NUBP1", "refseq_ac": "NP_036085", "gene_names_uniprotkb": "Nubp1", "gene_names_refseq": "Nubp1", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor NUBP1; NBP 1; Nucleotide-binding protein 1", "protein_names_refseq": "cytosolic Fe-S cluster assembly factor NUBP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26425)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10486206;16638812;19263241;21750661;23028652;23807208;26153462;28135057;28528544;31219806;38386558", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Implicated in the regulation of centrosome duplication (PubMed:16638812, PubMed:23807208). Negatively regulates cilium formation and structure (PubMed:23807208)., [UniProtKB, PubMed, HAMAP, PubMed]; KATNAL2 isoforms interact with themselves, with each other and with Nubp1 and Nubp2., [RefSeq, PubMed]; KIFC5A interacts with nucleotide-binding proteins 1 and 2 (Nubp1 and Nubp2). Nubp1 and Nubp2 also interact with each other., [RefSeq, PubMed]; Nr5a2 ensures inner cell mass formation in mouse blastocyst., [RefSeq, PubMed]; Nubp1 represents an essential protein for lung progenitor survival by coordinating vital cellular processes including cell polarity and centrosomal dynamics, [RefSeq, PubMed]; The C-terminal domain or motif of Nubp1 plays an important role in regulation of localization of Nubp1 protein., [RefSeq, PubMed]; The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U053;Q7TMI1;Q9CRM5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0072697 protein localization to cell cortex;GO:0006879 intracellular iron ion homeostasis;GO:0001558 regulation of cell growth;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9R060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES97-1", "uniprot_id": "RTN3_MOUSE", "mass": 103879.0, "length": 964, "protein_name": "Reticulon-3", "gene_name": "Rtn3", "organism": "Mouse", "refseq_name": "reticulon-3 isoform 2", "refseq_ac": "NP_001003933", "gene_names_uniprotkb": "Rtn3", "gene_names_refseq": "RTN3-A1; Rtn3", "protein_names_uniprotkb": "Reticulon-3", "protein_names_refseq": "Nsp-like II; reticulon-3 isoform 2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:20168); (R-MMU-8849932)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "10.3389/fragi.2021.757801;11990451;12832288;15350194;15946766;19665976;20173027;21183079;22517741;22645316;24262037;25428506;25612671;28135057;28528544;30084848;30779550;32848054;33300544;33725478;34428180;34678516;35822049;37228035;38017147;38937317;40021952;40885482;40997131", "class_list": "", "function": "CDNA of mouse reticulon 3 (mRTN3) was cloned. The gene was mapped at band B of chromosome 19., [RefSeq, PubMed]; Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis., [RefSeq, PubMed]; May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (PubMed:24262037). Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition (By similarity)., [UniProtKB, UniProtKB, PubMed]; RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity, [RefSeq, PubMed]; Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development., [RefSeq, PubMed]; Since other reports have shown that RTN4-A inhibits neuronal outgrowth and restricts the plasticity of the central nervous system, we speculate that RTN3-A1 might play certain roles in the central nervous system., [RefSeq, PubMed]; Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF62;Q544J1;Q68FE4;Q6IM69;Q6R8K6;Q6R8K7;Q6T929;Q8C6D5;Q8CCU2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0006915 apoptotic process;GO:1902430 negative regulation of amyloid-beta formation;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "Q9ES97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0GA42-1", "uniprot_id": "CNNM1_MOUSE", "mass": 103980.0, "length": 951, "protein_name": "Metal transporter CNNM1", "gene_name": "Cnnm1", "organism": "Mouse", "refseq_name": "metal transporter CNNM1 isoform 2", "refseq_ac": "NP_113573", "gene_names_uniprotkb": "Cnnm1; Acdp1", "gene_names_refseq": "Acdp1; CLP-1; Cnnm1", "protein_names_uniprotkb": "Metal transporter CNNM1; Ancient conserved domain-containing protein 1; CLP-1; Cyclin-M1; Cyclin-like protein 1; mACDP1", "protein_names_refseq": "ancient conserved domain protein 1; ancient conserved domain-containing protein 1; cyclin-like protein 1; metal transporter CNNM1 isoform 2; metal transporter CNNM1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83674)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14723793;17608643;21183079;21750661;22399287;22645316;27251091", "class_list": "", "function": "CNNM1 expression was restricted to c-KIT- and OCT3/4-positive cells in the testis, indicating that they are early spermatogonial cells. Spermatogonial stem cells in primary culture expressed Cnnm1, and their differentiation into embryoid body-like clusters in vitro resulted in the loss of Cnnm1 expression. Silencing of Cnnm1 in GC1-spg cells reduced number of cells in G1 phase with increased cells in S and G2/M phases., [RefSeq, PubMed]; Metal transporter., [UniProtKB, UniProtKB]; Probable metal transporter., [UniProtKB]; We determined that ACDP-1 is a high affinity copper binding protein able to bind copper at nanomolar concentrations. In addition the promoter of ACDP-1 contains metal response elements and cellular expression of ACDP-1 alters cellular retention of copper., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIQ6", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0010960 magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q0GA42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97291-1", "uniprot_id": "CADH8_MOUSE", "mass": 88215.0, "length": 799, "protein_name": "Cadherin-8", "gene_name": "Cdh8", "organism": "Mouse", "refseq_name": "cadherin-8 isoform 2 preproprotein", "refseq_ac": "NP_031693", "gene_names_uniprotkb": "Cdh8", "gene_names_refseq": "Cdh8; cad8", "protein_names_uniprotkb": "Cadherin-8", "protein_names_refseq": "cadherin-8 isoform 2 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12564); (R-MMU-418990)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;30899004;9022055", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit reduced behavioral responses to cold, but not thermal stimuli. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "G3UVU4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0043679 axon terminus;GO:0043083 synaptic cleft", "go_biological_process": "GO:0009409 response to cold;GO:0016477 cell migration;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02789-1", "uniprot_id": "CAC1S_MOUSE", "mass": 210320.0, "length": 1852, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1S", "gene_name": "Cacna1s", "organism": "Mouse", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1S isoform 1", "refseq_ac": "NP_055008", "gene_names_uniprotkb": "Cacna1s; Cach1b; Cach1; Cacn1; Cacnl1a3", "gene_names_refseq": "Cacna1s; Cav1.1; Cchl1a3; DHPR alpha1s; DHPR; fmd; mdg; sj", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1S; Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; DHPR; Dihydropyridine receptor; Voltage-gated calcium channel subunit alpha Cav1.1", "protein_names_refseq": "dihydropyridine receptor alpha 1S; muscle dysgenesis; voltage-dependent L-type calcium channel subunit alpha-1S isoform 1; voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel subunit alpha Cav1.1", "tax_id": 10090, "disease": "Timothy syndrome (Disease Ontology:DOID:0060173); congenital myopathy 18 (Disease Ontology:DOID:0081350); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (mmu:12292)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1281468;12871958;16550931;16638807;21183079;2173707;21750661;28351836;29467163;39927985", "class_list": "", "function": "Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9Q7B5;E9QPX8;F8VQE0;Q3UPG8;Q99240", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0036094 small molecule binding;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031674 I band;GO:0042383 sarcolemma;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0045933 positive regulation of muscle contraction;GO:0006936 muscle contraction;GO:0007528 neuromuscular junction development;GO:0006816 calcium ion transport;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q02789-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZF7-1", "uniprot_id": "CNNM4_MOUSE", "mass": 86626.0, "length": 771, "protein_name": "Metal transporter CNNM4", "gene_name": "Cnnm4", "organism": "Mouse", "refseq_name": "metal transporter CNNM4 precursor", "refseq_ac": "NP_291048", "gene_names_uniprotkb": "Cnnm4; Acdp4; Kiaa1592", "gene_names_refseq": "5430430O18Rik; Acdp4; Cnnm4", "protein_names_uniprotkb": "Metal transporter CNNM4; Ancient conserved domain-containing protein 4; Cyclin-M4; mACDP4", "protein_names_refseq": "ancient conserved domain protein 4; ancient conserved domain-containing protein 4; mACDP4; metal transporter CNNM4 precursor; metal transporter CNNM4", "tax_id": 10090, "disease": "Jalili syndrome (Disease Ontology:DOID:0111404)", "pathway": " (mmu:94220)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;14723793;19144319;19200525;19200527;21183079;22399287;25347473;25428506;30670776;30899004;36433951", "class_list": "", "function": "Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function., [UniProtKB, PubMed, PubMed]; Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage. Publication Status: Online-Only, [RefSeq, PubMed]; The importance of CNNM4 in maintaining the normal balance between cell proliferation and differentiation in the colon epithelia., [RefSeq, PubMed]; These results indicate that CNNM4-dependent Mg(2+) efflux suppresses tumor progression by regulating energy metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIM7", "ec_number_list": "", "go_molecular_function": "GO:0015081 sodium ion transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0007601 visual perception;GO:0070166 enamel mineralization;GO:0010960 magnesium ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q69ZF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZU6-1", "uniprot_id": "CISY_MOUSE", "mass": 51737.0, "length": 464, "protein_name": "Citrate synthase, mitochondrial", "gene_name": "Cs", "organism": "Mouse", "refseq_name": "citrate synthase, mitochondrial precursor", "refseq_ac": "NP_080720", "gene_names_uniprotkb": "Cs", "gene_names_refseq": "2610511A05Rik; 9030605P22Rik; Ahl4; Cis; Cs", "protein_names_uniprotkb": "Citrate synthase, mitochondrial; 2.3.3.1; Citrate (Si)-synthase", "protein_names_refseq": "citrate (Si)-synthase; citrate synthase, mitochondrial precursor; citrate synthase, mitochondrial", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); left ventricular failure (Disease Ontology:DOID:0051064); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); bipolar disorder (Disease Ontology:DOID:3312); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:12974); (R-MMU-71403); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21183079;23576753;23806337;36288343;37453647;37507081;39927985", "class_list": "", "function": "Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate., [UniProtKB]; The protein encoded by this gene is a central metabolic pathway enzyme, catalyzing the first step of the tricarboxylic acid cycle in which acetyl coenzyme A and oxaloacetate are converted to citrate and coenzyme A. This enzyme is found in nearly all cells capable of oxidative metabolism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDP3", "ec_number_list": "3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;3.1.2.-;3.1.2.2;3.4.21.92;1.1.1.37;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;1.1.1.42;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;1.1.1.30;2.7.11.2;6.1.1.5;2.7.1.23;3.4.21.53;5.6.2.3;2.3.1.9;2.3.1.37;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;1.3.8.1;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer;GO:0036440 citrate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0005975 carbohydrate metabolic process;GO:0006084 acetyl-CoA metabolic process;GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CZU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTX5-1", "uniprot_id": "SKP1_MOUSE", "mass": 18672.0, "length": 163, "protein_name": "S-phase kinase-associated protein 1", "gene_name": "Skp1", "organism": "Mouse", "refseq_name": "S-phase kinase-associated protein 1", "refseq_ac": "NP_035673", "gene_names_uniprotkb": "Skp1; Skp1a", "gene_names_refseq": "15kDa; 2610043E24Rik; 2610206H23Rik; EMC19; OCP-II; OCP2; Skp1a; Skp1; Tceb1l; p19A; p19Skp1", "protein_names_uniprotkb": "S-phase kinase-associated protein 1; Cyclin-A/CDK2-associated protein p19; S-phase kinase-associated protein 1A; p19A; p19skp1", "protein_names_refseq": "S-phase kinase-associated protein 1A; S-phase kinase-associated protein 1; cyclin-A/CDK2-associated protein p19", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:21402); (R-MMU-1169091); (R-MMU-1170546); (R-MMU-174113); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2565942); (R-MMU-2871837); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-68949); (R-MMU-69231); (R-MMU-69601); (R-MMU-8854050); (R-MMU-8939902); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-917937); (R-MMU-9708530); (R-MMU-9762114); (R-MMU-983168); (R-MMU-9929356)", "pathway_count": 27, "publication_count": 17, "publication_id_list": "10097128;11735228;12140560;19996097;21183079;21750661;22872234;23319590;28135057;29937374;31219806;34203471;34428180;35489071;36210013;36592647;9990853", "class_list": "", "function": "Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2 (By similarity). Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Also acts as a core component of the Cul1-RING(FBXL4) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of BNIP3 and BNIP3L (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Loss of SKP1 prior to meiosis leads to aberrant localization of DSB repair proteins and a failure in synapsis initiation in meiosis of both males and females as well as a defect in sister chromatid cohesion. FBXO47 interacts with SKP1 and HORMAD1 and targets HORMAD1 for polyubiquitination and degradation in HEK293T cells., [RefSeq, PubMed]; MiR-582-5p targets Skp1 and regulates NF-kappaB signaling-mediated inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5H6", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0008013 beta-catenin binding;GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:1990444 F-box domain binding", "go_cellular_component": "GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9WTX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZB6-1", "uniprot_id": "NR4A3_MOUSE", "mass": 68454.0, "length": 627, "protein_name": "Nuclear receptor subfamily 4 group A member 3", "gene_name": "Nr4a3", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 4 group A member 3 isoform 2", "refseq_ac": "NP_001294918", "gene_names_uniprotkb": "Nr4a3; Tec", "gene_names_refseq": "CHN; CSMF; MINOR; NOR-1; Nor1; Nr4a3; TEC", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 3; Orphan nuclear receptor TEC; Translocated in extraskeletal chondrosarcoma", "protein_names_refseq": "neural orphan receptor 1; nuclear receptor subfamily 4 group A member 3 isoform 2; orphan nuclear receptor TEC; translocated in extraskeletal chondrosarcoma", "tax_id": 10090, "disease": "extraskeletal myxoid chondrosarcoma (Disease Ontology:DOID:4549)", "pathway": " (mmu:18124); (R-MMU-383280)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10701778;11784868;12709428;13129926;15456880;18325999;18945812;19153266;19523439;20558821;20566846;21750661;21868379;23897430;24586680;24806827;27802388;38629274", "class_list": "", "function": "Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation., [RefSeq, PubMed]; This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]; Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner (PubMed:12709428). Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (PubMed:21868379). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner (PubMed:24806827). During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (PubMed:11784868). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance (PubMed:15456880, PubMed:20566846). Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (PubMed:19153266). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (PubMed:24586680). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1 (PubMed:19523439, PubMed:23897430). Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (PubMed:18325999). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (By similarity). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration (PubMed:13129926). Inhibits adipogenesis (PubMed:18945812). Also participates in cardiac hypertrophy by activating PARP1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZB5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0060005 vestibular reflex;GO:2000108 positive regulation of leukocyte apoptotic process;GO:0048752 semicircular canal morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QZB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5TVM2-1", "uniprot_id": "ILDR2_MOUSE", "mass": 73235.0, "length": 661, "protein_name": "Immunoglobulin-like domain-containing receptor 2", "gene_name": "Ildr2", "organism": "Mouse", "refseq_name": "immunoglobulin-like domain-containing receptor 2 isoform 1 precursor", "refseq_ac": "NP_001158000", "gene_names_uniprotkb": "Ildr2; D1Ertd471e; Ll", "gene_names_refseq": "2810478N18Rik; 3110063L10Rik; D1Ertd471e; Dbsm1; Ildr2; Ll", "protein_names_uniprotkb": "Immunoglobulin-like domain-containing receptor 2; Angulin-3; Lisch-like protein", "protein_names_refseq": "angulin-3; immunoglobulin-like domain-containing receptor 2 isoform 1 precursor; lisch-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039795)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;18654634;21183079;21750661;23239027;23826244;24129315;28785060;29431694;31219806;32312711;33863978;34428180;35820727;40885482", "class_list": "", "function": "Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)., [RefSeq, PubMed]; Manipulation of Ildr2 expression in liver affects both lipid homeostasis and ER stress pathways. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion (PubMed:23826244, PubMed:33863978). With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (PubMed:23239027). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B5TVM3;B5TVM4;B5TVM5;B5TVM6;B5TVM7;B5TVM8;B5TVM9;E9Q9U5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0070160 tight junction", "go_biological_process": "GO:0030154 cell differentiation;GO:0048873 homeostasis of number of cells within a tissue;GO:0031016 pancreas development;GO:0009749 response to glucose;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "B5TVM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CID0-1", "uniprot_id": "CSR2B_MOUSE", "mass": 88217.0, "length": 779, "protein_name": "Cysteine-rich protein 2-binding protein", "gene_name": "Kat14", "organism": "Mouse", "refseq_name": "cysteine-rich protein 2-binding protein isoform 1", "refseq_ac": "NP_852082", "gene_names_uniprotkb": "Kat14; Csrp2bp", "gene_names_refseq": "2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e; D2Wsu131e; E430020F17; Kat14", "protein_names_uniprotkb": "Cysteine-rich protein 2-binding protein; ADA2A-containing complex subunit 2; ATAC2; CRP2-binding partner; CRP2BP; CSRP2-binding protein; Lysine acetyltransferase 14", "protein_names_refseq": "ADA2A-containing complex subunit 2; CRP2-binding partner; CRP2BP; CSRP2-binding protein; cysteine and glycine-rich protein 2 binding protein; cysteine-rich protein 2-binding protein isoform 1; cysteine-rich protein 2-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:228714); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19103755;21750661;23806337;27940555;38867256;40021952", "class_list": "", "function": "CSRP2BP strongly potentiates the expression of SRF smooth muscle target genes together with either Myocardin or CRP2, [RefSeq, PubMed]; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity)., [UniProtKB]; Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in ovarian endometrioma via co-operation with serum response factor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2ANA8", "ec_number_list": "", "go_molecular_function": "GO:0004402 histone acetyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072686 mitotic spindle;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CID0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00560-1", "uniprot_id": "IL6RB_MOUSE", "mass": 102451.0, "length": 917, "protein_name": "Interleukin-6 receptor subunit beta", "gene_name": "Il6st", "organism": "Mouse", "refseq_name": "interleukin-6 receptor subunit beta precursor", "refseq_ac": "NP_034690", "gene_names_uniprotkb": "Il6st", "gene_names_refseq": "5133400A03Rik; CD130; D13Ertd699e; Il6st; gp130", "protein_names_uniprotkb": "Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; Interleukin-6 signal transducer; Membrane glycoprotein 130; Oncostatin-M receptor subunit alpha; gp130", "protein_names_refseq": "IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; interleukin-6 receptor subunit beta precursor; interleukin-6 receptor subunit beta; membrane glycoprotein 130; oncostatin-M receptor subunit alpha", "tax_id": 10090, "disease": "immunodeficiency 94 (Disease Ontology:DOID:0061064); hyper IgE recurrent infection syndrome 4 (Disease Ontology:DOID:0080596); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hyperandrogenism (Disease Ontology:DOID:11613); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:16195); (R-MMU-1059683); (R-MMU-110056); (R-MMU-112411); (R-MMU-6788467); (R-MMU-8984722); (R-MMU-9020956); (R-MMU-9958825)", "pathway_count": 8, "publication_count": 37, "publication_id_list": "10.1101/2023.09.13.557529;10377352;10661409;11465105;1602143;16075062;17105399;17675186;19136654;19144319;19349973;21183079;21750661;22645316;24339143;25057188;25228504;25428506;25731159;26255596;26495903;27802388;27893700;28011936;28402851;28935714;30084848;30779550;30899004;31219806;31599954;35984892;37828378;8552649;9202125;9348227;9920829", "class_list": "", "function": "Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric complex CRLF1-CLCF1 (PubMed:1602143). Engages site 2 of CNTF, CLCF1, LIF, and IL-6, and site 3 of IL27 and IL6. Initiates signal transmission through three mechanisms (By similarity). Binding of cytokines, such as IL6 or IL11 to the alpha-chains of their specific cell surface receptor triggers homodimerization of IL6ST/gp130 (PubMed:10661409, PubMed:1602143). In contrast, binding of other IL-6 family cytokines can result in the formation of a IL6ST/gp130 heterodimer with another signal-transducing receptor, such as LIFR or OSMR (By similarity). Moreover, binding of CNTF or CLCF1 or the heterodimeric complex CRLF1-CLCF1 or MT-RNR2/humanin to the non-signaling receptor CNTFR induces heterodimerization of the IL6ST/gp130 with LIFR or IL27RA/WSX1 (in the case of MT-RNR2/humanin) (By similarity). Mechanistically, homodimerization or heterodimerization of IL6ST/gp130 activate JAK tyrosine kinases bound to their intracellular domains (PubMed:10661409, PubMed:1602143). These kinases subsequently phosphorylate the homodimer or heterodimer form of IL6ST/gp130 (PubMed:10661409, PubMed:1602143). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STATs) (PubMed:10661409, PubMed:1602143). The IL6 signaling pathway induces, in parallel, the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (PubMed:9202125). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (PubMed:25731159). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:25057188, PubMed:26255596, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (By similarity) (PubMed:24339143, PubMed:26255596, PubMed:9348227)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 11, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "G5E8D2", "ec_number_list": "", "go_molecular_function": "GO:0004897 ciliary neurotrophic factor receptor activity;GO:0004915 interleukin-6 receptor activity;GO:0019981 interleukin-6 binding;GO:0004923 leukemia inhibitory factor receptor activity;GO:0015026 coreceptor activity", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005896 interleukin-6 receptor complex;GO:0005900 oncostatin-M receptor complex;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0038165 oncostatin-M-mediated signaling pathway;GO:0070104 negative regulation of interleukin-6-mediated signaling pathway;GO:0070106 interleukin-27-mediated signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 7.1, "record_id": "Q00560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07901-1", "uniprot_id": "HS90A_MOUSE", "mass": 84788.0, "length": 733, "protein_name": "Heat shock protein HSP 90-alpha", "gene_name": "Hsp90aa1", "organism": "Mouse", "refseq_name": "heat shock protein HSP 90-alpha", "refseq_ac": "NP_034610", "gene_names_uniprotkb": "Hsp90aa1; Hsp86-1; Hsp86; Hspca", "gene_names_refseq": "86kDa; 89kDa; Hsp86-1; Hsp89; Hsp90aa1; Hsp90; Hspca; hsp4", "protein_names_uniprotkb": "Heat shock protein HSP 90-alpha; 3.6.4.10; HSP 86; HSP86; Heat shock 86 kDa; TSTA; Tumor-specific transplantation 86 kDa antigen", "protein_names_refseq": "HSP 86; HSP86; TSTA; heat shock 86 kDa; heat shock protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein HSP 90-alpha; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; tumor-specific transplantation 86 kDa antigen", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); varicocele (Disease Ontology:DOID:12337); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:15519); (R-MMU-1227986); (R-MMU-1474151); (R-MMU-168928); (R-MMU-2029482); (R-MMU-203615); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-3371511); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-399954); (R-MMU-4420097); (R-MMU-5218920); (R-MMU-5620912); (R-MMU-5675482); (R-MMU-6798695); (R-MMU-8852276); (R-MMU-8854518); (R-MMU-8863795); (R-MMU-8939211); (R-MMU-9009391); (R-MMU-9013418); (R-MMU-9018519); (R-MMU-9652282)", "pathway_count": 29, "publication_count": 48, "publication_id_list": "10.1101/2023.09.13.557529;10409742;11278753;11751894;16139798;17208939;17242355;17947660;18034455;18630941;19144319;1916807;21183079;21540332;21750661;22081021;22431752;22556278;22645316;23806337;2469626;24713123;24788674;2507541;25605945;26495903;27496612;27686098;2806771;29125738;29127155;2925609;30899004;31219806;33300544;33725478;34428180;3458168;34887587;35820727;37453647;37507081;37828378;39128813;39627609;39927985;8289821;9195923", "class_list": "", "function": "Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and differentiation of NSPCs, promoting the onset and progression of early post-ischemic stroke epilepsy., [RefSeq, PubMed]; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.1.-.-;3.4.22.52;3.4.19.12;7.6.2.1;2.7.11.1;3.6.1.5;3.4.22.27;1.1.1.42;3.4.24.-;3.6.-.-;3.4.21.46;4.1.2.13;2.7.11.11;3.6.5.-;2.7.10.2;5.3.1.9;5.1.3.-;2.4.2.7;3.1.3.1;3.9.1.1;1.16.3.1;4.2.1.24;3.4.22.1;2.7.11.22;2.7.11.23;3.6.1.-;3.2.1.31;2.7.1.11;5.2.1.8;3.4.23.5;2.5.1.18;5.6.2.5;4.2.99.18;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;3.6.4.12;5.6.1.6;5.3.2.1;5.3.3.12;2.7.10.1;3.4.24.35;3.6.4.6;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.1.40;3.6.5.2;3.5.4.5;3.6.1.15;3.1.4.-;3.4.25.1;1.14.13.39;2.7.11.39;2.7.4.6;2.7.13.3;2.7.11.21;5.6.2.-;2.7.1.1;2.7.1.-;7.2.2.-;7.6.2.16;3.1.3.16;3.1.1.47;2.3.2.26;5.4.2.2;5.4.2.7;3.1.6.14;3.1.26.-;3.4.21.53;2.7.7.7;2.7.7.49;2.7.1.35;3.4.19.1;3.6.1.6;2.7.4.3;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.7.11.26;2.4.1.1;3.1.11.-;2.4.1.186;5.3.99.3;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0030911 TPR domain binding;GO:0032564 dATP binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0003009 skeletal muscle contraction;GO:0009409 response to cold;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "P07901-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28028-3", "uniprot_id": "BRAF_MOUSE", "mass": 82515.0, "length": 751, "protein_name": "Serine/threonine-protein kinase B-raf", "gene_name": "Braf", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase B-raf", "refseq_ac": "NP_647455", "gene_names_uniprotkb": "Braf; B-raf", "gene_names_refseq": "9930012E13Rik; B-raf; Braf-2; Braf2; Braf; C230098H17; D6Ertd631e", "protein_names_uniprotkb": "Serine/threonine-protein kinase B-raf; 2.7.11.1; Proto-oncogene B-Raf", "protein_names_refseq": "B-Raf proto-oncogene serine/threonine-protein kinase (p94); Braf transforming; proto-oncogene B-Raf; serine/threonine-protein kinase B-raf", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); Noonan syndrome 7 (Disease Ontology:DOID:0060585); Noonan syndrome with multiple lentigines 3 (Disease Ontology:DOID:0080550); cardiofaciocutaneous syndrome 1 (Disease Ontology:DOID:0111460); lung cancer (Disease Ontology:DOID:1324); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); prostate adenocarcinoma (Disease Ontology:DOID:2526); Langerhans-cell histiocytosis (Disease Ontology:DOID:2571); dysembryoplastic neuroepithelial tumor (Disease Ontology:DOID:2679); endometrial carcinoma (Disease Ontology:DOID:2871); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); germinoma (Disease Ontology:DOID:3304); papillary thyroid carcinoma (Disease Ontology:DOID:3969); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); cholangiocarcinoma (Disease Ontology:DOID:4947); bile duct adenoma (Disease Ontology:DOID:5381); pancreatic acinar cell adenocarcinoma (Disease Ontology:DOID:5742); familial melanoma (Disease Ontology:DOID:6846); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:109880); (R-MMU-1295596); (R-MMU-170968); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5674499); (R-MMU-5675221)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "17242355;2052597;21102438;21183079;21917714;31219806;33300544;34428180", "class_list": "", "function": "Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2 (By similarity). May play a role in the postsynaptic responses of hippocampal neurons., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 26, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNG9;F6SZ47;Q3USE9", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;3.6.5.2;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.6.4.-;3.1.3.53;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;2.3.2.27;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0031434 mitogen-activated protein kinase kinase binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0002318 myeloid progenitor cell differentiation;GO:0010764 negative regulation of fibroblast migration;GO:0030878 thyroid gland development;GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P28028-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AW69-4", "uniprot_id": "CGNL1_MOUSE", "mass": 148169.0, "length": 1297, "protein_name": "Cingulin-like protein 1", "gene_name": "Cgnl1", "organism": "Mouse", "refseq_name": "cingulin-like protein 1", "refseq_ac": "NP_001291291", "gene_names_uniprotkb": "Cgnl1; Jacop; Kiaa1749", "gene_names_refseq": "4933421H10Rik; 9930020M10Rik; Cgnl1; Jacop", "protein_names_uniprotkb": "Cingulin-like protein 1; Junction-associated coiled-coil protein", "protein_names_refseq": "cingulin-like protein 1; junction-associated coiled-coil protein; paracingulin", "tax_id": 10090, "disease": "", "pathway": " (mmu:68178)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15292197;17242355;21183079;25428506;29016873;30084848;37013686", "class_list": "", "function": "Demonstrate a functional relevance for cingulin-like 1 as a defining factor in new vessel formation both in vitro and in vivo, [RefSeq, PubMed]; JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons., [RefSeq, PubMed]; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons., [UniProtKB, PubMed]; Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization., [RefSeq, PubMed]; This gene encodes a protein localized to the tight junctions and adherens junctions in vertebrate epithelial cells. The encoded protein regulates the activity of Rho family GTPases during junction assembly and at confluence. At the adherens junctions, the encoded protein is part of a protein complex that links E-cadherin to the microtubule cytoskeleton. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSU6;Q5U5U0;Q69ZB4;Q8BLZ5;Q8BZ26;Q9D2T3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0015629 actin cytoskeleton;GO:0030054 cell junction;GO:0032991 protein-containing complex;GO:0016459 myosin complex", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0001525 angiogenesis;GO:0007015 actin filament organization;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0045184 establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6AW69-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1T1-1", "uniprot_id": "CHMP7_MOUSE", "mass": 50633.0, "length": 451, "protein_name": "Charged multivesicular body protein 7", "gene_name": "Chmp7", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 7", "refseq_ac": "NP_598839", "gene_names_uniprotkb": "Chmp7", "gene_names_refseq": "4930596K11Rik; 6330407G04Rik; Chmp7", "protein_names_uniprotkb": "Charged multivesicular body protein 7; Chromatin-modifying protein 7", "protein_names_refseq": "CHMP family, member 7; charged multivesicular body protein 7; chromatin-modifying protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:105513); (R-MMU-1632852); (R-MMU-5620971); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15345747;21183079;26495903;30837566", "class_list": "", "function": "ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (By similarity). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (By similarity). Recruited to the reforming NE during anaphase by LEMD2 (By similarity). Plays a role in the endosomal sorting pathway (By similarity)., [UniProtKB, UniProtKB]; Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFW4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:0061763 multivesicular body-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R1T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKL5-1", "uniprot_id": "CHP3_MOUSE", "mass": 24600.0, "length": 214, "protein_name": "Calcineurin B homologous protein 3", "gene_name": "Tesc", "organism": "Mouse", "refseq_name": "calcineurin B homologous protein 3", "refseq_ac": "NP_067319", "gene_names_uniprotkb": "Tesc; Chp3", "gene_names_refseq": "1010001A17Rik; 2410011K10Rik; TE-1; Tesc", "protein_names_uniprotkb": "Calcineurin B homologous protein 3; TE-1; TSC; Tescalcin", "protein_names_refseq": "CHP3; TSC; calcineurin B homologous protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:57816)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11145610;14661968;17717601;19345287;22285131;27939885", "class_list": "", "function": "Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin., [UniProtKB, PubMed]; TESC has an important role in mediating the neuroprotective effect of class I histone deacetylase inhibitors, and may also be involved in the development of brain and neurodegenerative diseases through epigenetic mechanisms, [RefSeq, PubMed]; Tescalcin shares sequence and functional homology with calcineurin-B homologous protein (CHP), and like CHP can inhibit the phosphatase activity of calcineurin A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32Q85;Q8VCN1", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0004860 protein kinase inhibitor activity;GO:0019212 phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0030854 positive regulation of granulocyte differentiation;GO:0033628 regulation of cell adhesion mediated by integrin;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64458-1", "uniprot_id": "CP2CT_MOUSE", "mass": 55716.0, "length": 490, "protein_name": "Cytochrome P450 2C29", "gene_name": "Cyp2c29", "organism": "Mouse", "refseq_name": "cytochrome P450 2C29 isoform 1 precursor", "refseq_ac": "NP_031841", "gene_names_uniprotkb": "Cyp2c29", "gene_names_refseq": "AHOHase; AHOH; Ah-2; Ahh-1; Cyp2c29; Cyp2c; P450-2C", "protein_names_uniprotkb": "Cytochrome P450 2C29; 1.14.14.1; Aldehyde oxygenase; CYPIIC29; Cytochrome P-450 MUT-2", "protein_names_refseq": "CYPIIC29; aldehyde oxygenase; cytochrome P-450 MUT-2; cytochrome P450 2C29 isoform 1 precursor; cytochrome P450 2C29; cytochrome P450, 2c29", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:13095)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21750661;23576753;24519941;25428506;30084848;32587777;34428180;34438105;35748067;37453647;8130255;9721182", "class_list": "", "function": "A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of 14,15 double bond of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 14,15-epoxyeicosatrienoic acid (14,15-EET) regioisomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase)., [UniProtKB, PubMed]; Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage., [RefSeq, PubMed]; Gene-targeted knockdown of CYP2C55, the homologous gene of CYP2C9, demonstrated viability rescue to light-induced cell death, whereas stable expression of functional CYP2C9-GFP fusion protein further exacerbated light-induced cell death., [RefSeq, PubMed]; Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage., [RefSeq, PubMed]; Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QMD8;Q8WUN8", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q64458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z111-1", "uniprot_id": "GA45G_MOUSE", "mass": 17211.0, "length": 159, "protein_name": "Growth arrest and DNA damage-inducible protein GADD45 gamma", "gene_name": "Gadd45g", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gadd45g; Cr6", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth arrest and DNA damage-inducible protein GADD45 gamma; Cytokine-responsive protein CR6", "protein_names_refseq": "", "tax_id": 10090, "disease": "mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10490824", "class_list": "", "function": "Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0046330 positive regulation of JNK cascade;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z111-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UGR5-1", "uniprot_id": "HDHD2_MOUSE", "mass": 28730.0, "length": 259, "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "gene_name": "Hdhd2", "organism": "Mouse", "refseq_name": "haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1", "refseq_ac": "NP_001034290", "gene_names_uniprotkb": "Hdhd2", "gene_names_refseq": "0610039H12Rik; 3110052N05Rik; Hdhd2", "protein_names_uniprotkb": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "protein_names_refseq": "haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1; haloacid dehalogenase-like hydrolase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76987)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23806337;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8M0;Q6PEB2;Q9CXN1;Q9DCF2", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UGR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMG7-1", "uniprot_id": "HDGR3_MOUSE", "mass": 22431.0, "length": 202, "protein_name": "Hepatoma-derived growth factor-related protein 3", "gene_name": "Hdgfl3", "organism": "Mouse", "refseq_name": "hepatoma-derived growth factor-related protein 3", "refseq_ac": "NP_038914", "gene_names_uniprotkb": "Hdgfl3; Hdgfrp3", "gene_names_refseq": "2700022B06Rik; HRP-3; Hdgfl3; Hdgfrp3", "protein_names_uniprotkb": "Hepatoma-derived growth factor-related protein 3; HRP-3", "protein_names_refseq": "hepatoma-derived growth factor, related protein 3; hepatoma-derived growth factor-related protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:29877)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10581169;15689505;20890995;21183079;32647008", "class_list": "", "function": "Antibody-mediated neutralization of HRP-3 function results in neuronal degeneration; this protein also exerts a neurite outgrowth-promoting effect when it is presented as a coated substrate but not as a soluble factor., [RefSeq, PubMed]; Enhances DNA synthesis and may play a role in cell proliferation., [UniProtKB]; Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRX2;Q8BQ69;Q8BR62;Q9D2M7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008017 microtubule binding;GO:0008083 growth factor activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0031175 neuron projection development;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JMG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49429-1", "uniprot_id": "HPPD_MOUSE", "mass": 45054.0, "length": 393, "protein_name": "4-hydroxyphenylpyruvate dioxygenase", "gene_name": "Hpd", "organism": "Mouse", "refseq_name": "4-hydroxyphenylpyruvate dioxygenase", "refseq_ac": "NP_032303", "gene_names_uniprotkb": "Hpd", "gene_names_refseq": "4HPPD; Fla; Flp; Hpd; Hppd; Laf", "protein_names_uniprotkb": "4-hydroxyphenylpyruvate dioxygenase; 1.13.11.27; 2.1.1.348; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; F Alloantigen; F protein; HPD; HPPDase; N(6)-adenosine-methyltransferase HPD", "protein_names_refseq": "4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; F liver antigen; F protein; HPPDase; f Alloantigen", "tax_id": 10090, "disease": "tyrosinemia type III (Disease Ontology:DOID:0050727); hawkinsinuria (Disease Ontology:DOID:0111362)", "pathway": " (mmu:15445); (R-MMU-8963684)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16899383;1709870;17242355;21183079;21750661;23806337;30297903;31537781;34428180;37453647;7774914", "class_list": "", "function": "Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs., [UniProtKB, UniProtKB]; Gene expressions in tyrosinemia type I model mice with liver failure using microarrays. Numerous genes, including amino acid metabolism and apoptosis related genes, were up- or down-regulated at the onset of liver failure., [RefSeq, PubMed]; The findings reveal a previously unknown regulation of 4-hydroxyphenylpyruvic acid dioxygenase (HPD) expression and highlight the physiological significance of TTC36-STK33-PELI1-regulated HPD expression in tyrosinemia and tyrosinemia-associated neurological disorders. Publication Status: Online-Only, [RefSeq, PubMed]; We observed long-term postnatal persistence of edited cells in both models, with reduction of plasma PCSK9 and cholesterol levels following in utero Pcsk9 targeting and rescue of the lethal phenotype of hereditary tyrosinemia type 1 following in utero Hpd targeting, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97322;Q3UEQ0;Q91WV9", "ec_number_list": "1.13.11.27;2.1.1.348;2.1.1.-;2.1.1.346", "go_molecular_function": "GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity;GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P49429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38060-1", "uniprot_id": "HMGCL_MOUSE", "mass": 34239.0, "length": 325, "protein_name": "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "gene_name": "Hmgcl", "organism": "Mouse", "refseq_name": "hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 precursor", "refseq_ac": "NP_032280", "gene_names_uniprotkb": "Hmgcl", "gene_names_refseq": "HL; Hmgcl", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA lyase, mitochondrial; 3-hydroxy-3-methylglutarate-CoA lyase; 4.1.3.4; HL; HMG-CoA lyase", "protein_names_refseq": "3-hydroxy-3-methylglutarate-CoA lyase; HMG-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 precursor; hydroxymethylglutaryl-CoA lyase, mitochondrial", "tax_id": 10090, "disease": "3-hydroxy-3-methylglutaryl-CoA lyase deficiency (Disease Ontology:DOID:0070541); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:15356); (R-MMU-77111); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "23576753;23806337;28135057;31219806;34428180;36288343;36923932;37453647;37507081;7527399;8102917;8617516", "class_list": "", "function": "Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism., [UniProtKB, UniProtKB]; Phosphorylation by IKKbeta Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZS6", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0046872 metal ion binding;GO:0005198 structural molecule activity;GO:0031406 carboxylic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0046951 ketone body biosynthetic process;GO:0007005 mitochondrion organization;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70333-1", "uniprot_id": "HNRH2_MOUSE", "mass": 49280.0, "length": 449, "protein_name": "Heterogeneous nuclear ribonucleoprotein H2", "gene_name": "Hnrnph2", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein H2", "refseq_ac": "NP_001300645", "gene_names_uniprotkb": "Hnrnph2; Hnrph2", "gene_names_refseq": "DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrnph2; Hnrph2", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein H2; Heterogeneous nuclear ribonucleoprotein H'; hnRNP H'; hnRNP H2", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein H'; heterogeneous nuclear ribonucleoprotein H2; hnRNP H'; hnRNP H2", "tax_id": 10090, "disease": "syndromic X-linked intellectual developmental disorder bain type (Disease Ontology:DOID:0070538)", "pathway": " (mmu:56258); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21183079;22645316;24129315;24788674;25428506;30084848;33300544;34428180;35820727;37453647;37463454;7626884", "class_list": "", "function": "A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1. Erratum:[J Clin Invest. 2024 Apr 15;134(8):e181331. doi: 10.1172/JCI181331. PMID: 38618962] Publication Status: Online-Only, [RefSeq, PubMed]; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THV9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P70333-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88728-1", "uniprot_id": "IFM5_MOUSE", "mass": 14667.0, "length": 134, "protein_name": "Interferon-induced transmembrane protein 5", "gene_name": "Ifitm5", "organism": "Mouse", "refseq_name": "interferon-induced transmembrane protein 5", "refseq_ac": "NP_444318", "gene_names_uniprotkb": "Ifitm5; Bril; Fragilis4", "gene_names_refseq": "1110003J06Rik; Bril; DSPA1; Hrmp1; Hrtm1; Ifitm5", "protein_names_uniprotkb": "Interferon-induced transmembrane protein 5; Bone-restricted interferon-induced transmembrane protein-like protein; Bril; DSPA1; Dispanin subfamily A member 1; Fragilis family member 4", "protein_names_refseq": "bone-restricted interferon induced transmembrane protein-like protein; dispanin subfamily A member 1; fragilis family member 4; haemopoiesis related membrane protein 1; interferon-induced transmembrane protein 5", "tax_id": 10090, "disease": "osteogenesis imperfecta type 5 (Disease Ontology:DOID:0110344)", "pathway": " (mmu:73835)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11106657;12659663;18442316;20838829;22363774;24058703;24715519;38885336", "class_list": "", "function": "Bril is a novel osteoblast protein and showed a role in mineralization, possibly identifying a new regulatory pathway in bone formation., [RefSeq, PubMed]; Required for normal bone mineralization., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001501 skeletal system development;GO:0060349 bone morphogenesis;GO:0030500 regulation of bone mineralization;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WM4-1", "uniprot_id": "HPLN4_MOUSE", "mass": 42809.0, "length": 400, "protein_name": "Hyaluronan and proteoglycan link protein 4", "gene_name": "Hapln4", "organism": "Mouse", "refseq_name": "hyaluronan and proteoglycan link protein 4 precursor", "refseq_ac": "NP_808568", "gene_names_uniprotkb": "Hapln4; Bral2; Lpr4", "gene_names_refseq": "9330174O11; Bral2; Hapln4; Lpr4", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 4; Brain link protein 2", "protein_names_refseq": "brain link protein 2; brain linked protein 2; hyaluronan and proteoglycan link protein 4 precursor; link protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:330790)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12663660;14550776;22121037;29020454;30125937;30899004;31664654;33300544", "class_list": "glycogene", "function": "Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (PubMed:22121037). Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (PubMed:30125937)., [UniProtKB, PubMed, PubMed]; The Effect of Hapln4 Link Protein Deficiency on Extracellular Space Diffusion Parameters and Perineuronal Nets in the Auditory System During Aging., [RefSeq, PubMed]; The efficiency of the pre-pulse inhibition of the acoustic startle reflex significantly increased in post-natal wild-type mice compared to Bral2 knock-out mice., [RefSeq, PubMed]; These results imply that Bral2-brevican interaction may play a key role in synaptic stabilization and the structural integrity of brain perineuronal nets, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05AB1;Q80XX2", "ec_number_list": "", "go_molecular_function": "GO:0005540 hyaluronic acid binding;GO:0150043 structural constituent of synapse-associated extracellular matrix", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80WM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01582-1", "uniprot_id": "IL1A_MOUSE", "mass": 31023.0, "length": 270, "protein_name": "Interleukin-1 alpha", "gene_name": "Il1a", "organism": "Mouse", "refseq_name": "interleukin-1 alpha", "refseq_ac": "NP_034684", "gene_names_uniprotkb": "Il1a", "gene_names_refseq": "Il-1a; Il1a", "protein_names_uniprotkb": "Interleukin-1 alpha; IL-1 alpha", "protein_names_refseq": "IL-1 alpha; interleukin-1 alpha", "tax_id": 10090, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); urinary tract infection (Disease Ontology:DOID:0080784); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); endometritis (Disease Ontology:DOID:1002); keratoconus (Disease Ontology:DOID:10126); common cold (Disease Ontology:DOID:10459); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); cholesteatoma of middle ear (Disease Ontology:DOID:10964); corneal edema (Disease Ontology:DOID:11030); osteoporosis (Disease Ontology:DOID:11476); beta thalassemia (Disease Ontology:DOID:12241); vitiligo (Disease Ontology:DOID:12306); varicocele (Disease Ontology:DOID:12337); uveitis (Disease Ontology:DOID:13141); cholestasis (Disease Ontology:DOID:13580); Fabry disease (Disease Ontology:DOID:14499); cystic fibrosis (Disease Ontology:DOID:1485); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); Schnitzler syndrome (Disease Ontology:DOID:4371); pneumonia (Disease Ontology:DOID:552); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); cholesteatoma (Disease Ontology:DOID:869); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16175); (R-MMU-448706); (R-MMU-5620971); (R-MMU-9020702)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1386364;16256210;31219806;3126184;34428180;6209582;8565056", "class_list": "", "function": "Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:16256210). After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways (PubMed:1386364). Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as a signal for genotoxic stress without loss of cell integrity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005507 copper ion binding;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0033092 positive regulation of immature T cell proliferation in thymus;GO:0001660 fever generation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01582-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNI7-1", "uniprot_id": "IL17F_MOUSE", "mass": 17941.0, "length": 161, "protein_name": "Interleukin-17F", "gene_name": "Il17f", "organism": "Mouse", "refseq_name": "interleukin-17F precursor", "refseq_ac": "NP_665855", "gene_names_uniprotkb": "Il17f", "gene_names_refseq": "IL-17F; Il17f", "protein_names_uniprotkb": "Interleukin-17F; IL-17F", "protein_names_refseq": "interleukin-17F precursor", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); leprosy (Disease Ontology:DOID:1024); pneumoconiosis (Disease Ontology:DOID:10316); silicosis (Disease Ontology:DOID:10325); diffuse scleroderma (Disease Ontology:DOID:1580); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:257630)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12077275;15477493;16990136;17218320;17911633;18025225;19144317;21750661;23255360;28813677;29915298;32076265", "class_list": "", "function": "A role for IL-17F in the induction of neutrophilia in the lungs and in the exacerbation of Ag-induced pulmonary inflammation., [RefSeq, PubMed]; Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:18025225, PubMed:19144317, PubMed:23255360). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:15477493, PubMed:17911633, PubMed:18025225). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (PubMed:18025225, PubMed:23255360). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (PubMed:29915298)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Intranasal administration of adenovirus expressing IL-17F results in bronchoalveolar lavage neutrophilia and inflammatory gene expression in the lung., [RefSeq, PubMed]; THi cell differentiation is associated with epigenetic changes in the IL-17-IL-17F locus, which suggests novel mechanisms in T cell functional regulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4C3", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0019955 cytokine binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7TNI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZQ4-1", "uniprot_id": "PAXI1_MOUSE", "mass": 119269.0, "length": 1056, "protein_name": "PAX-interacting protein 1", "gene_name": "Paxip1", "organism": "Mouse", "refseq_name": "PAX-interacting protein 1", "refseq_ac": "NP_061366", "gene_names_uniprotkb": "Paxip1; Ptip", "gene_names_refseq": "D5Ertd149e; PTIP; Paxip1", "protein_names_uniprotkb": "PAX-interacting protein 1; PAX transactivation activation domain-interacting protein", "protein_names_refseq": "PAX transactivation activation domain-interacting protein; PAX-interacting protein 1", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:55982); (R-MMU-5693571); (R-MMU-9772755); (R-MMU-9818564)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10908331;12588986;17429055;17500065;17925232;19124460;19414588;20671152;21183079;21750661;25428506;26744420;34428180;36924252;37272101;39097652", "class_list": "", "function": "Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes such as the MLL2/MLL3 complex. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires Rnf8 and Ube2n. Recruits Tp53bp1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with Tp53bp1 phosphorylated by Atm. Together with Tp53bp1 regulates Atm association (By similarity). Proposed to recruit Pagr1 to sites of DNA damage and the Pagr1:Paxip1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, this function has been questioned (PubMed:19124460, PubMed:26744420). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and Rad51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as Pax2. Associates with gene promoters that are known to be regulated by Kmt2d/Mll2 (By similarity). During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (PubMed:20671152, PubMed:26744420)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PTIP Deficiency in B Lymphocytes Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice., [RefSeq, PubMed]; PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1. Publication Status: Online-Only, [RefSeq, PubMed]; PTIP is an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways, [RefSeq, PubMed]; Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity. Publication Status: Online-Only, [RefSeq, PubMed]; Pax transactivation domain-interacting protein is required for the urine concentration mechanism by modulating arginine vasopressin receptor 2 and AQP2 expression in the inner medulla., [RefSeq, PubMed]; This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013]., [RefSeq]; Without DNA damage agent treatment, endogenous PTIP associates with MLL3- and MLL4-containing histone H3 K4 methyltransferase complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, PA1 and JmjC domain-containing putative histone demethylase UTX., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z0W6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016363 nuclear matrix;GO:0005694 chromosome;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0060717 chorion development;GO:0001570 vasculogenesis;GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6NZQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32300-1", "uniprot_id": "OPRD_MOUSE", "mass": 40561.0, "length": 372, "protein_name": "Delta-type opioid receptor", "gene_name": "Oprd1", "organism": "Mouse", "refseq_name": "delta-type opioid receptor", "refseq_ac": "NP_038650", "gene_names_uniprotkb": "Oprd1", "gene_names_refseq": "DOR-1; DOR; Nbor; Oprd1; mDOR", "protein_names_uniprotkb": "Delta-type opioid receptor; D-OR-1; DOR-1; K56; MSL-2", "protein_names_refseq": "D-OR-1; K56; MSL-2; delta 1 opioid receptor; delta-type opioid receptor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); opioid abuse (Disease Ontology:DOID:11206); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); opiate dependence (Disease Ontology:DOID:2559); myocardial infarction (Disease Ontology:DOID:5844); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18386); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10677041;1334555;1335167;18836069;19412545;22596164;38909535;8393575;8397421;8415697;8844829", "class_list": "", "function": "G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine., [UniProtKB, PubMed, PubMed, PubMed]; Neuroprotective effects of miRNA-326 knockout in neonatal hypoxic-ischemic brain damage mice via the delta-opioid receptor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038046 G protein-coupled enkephalin receptor activity;GO:0004985 G protein-coupled opioid receptor activity;GO:0033612 receptor serine/threonine kinase binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043679 axon terminus;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008344 adult locomotory behavior;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50580-1", "uniprot_id": "PA2G4_MOUSE", "mass": 43699.0, "length": 394, "protein_name": "Proliferation-associated protein 2G4", "gene_name": "Pa2g4", "organism": "Mouse", "refseq_name": "proliferation-associated protein 2G4", "refseq_ac": "NP_035249", "gene_names_uniprotkb": "Pa2g4; Ebp1; Plfap", "gene_names_refseq": "38kDa; Ebp1; Pa2g4; Plfap", "protein_names_uniprotkb": "Proliferation-associated protein 2G4; IRES-specific cellular trans-acting factor 45 kDa; ITAF45; Mpp1; Proliferation-associated protein 1; Protein p38-2G4", "protein_names_refseq": "ErbB3-binding protein 1; IRES-specific cellular trans-acting factor 45 kDa; ITAF45; mpp1; proliferation-associated 2G4, 38kD; proliferation-associated protein 1; proliferation-associated protein 2G4; protein p38-2G4", "tax_id": 10090, "disease": "", "pathway": " (mmu:18813); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10950867;15064750;16452087;17690690;18299400;20484733;25428506;25605945;26740625;27802388;29125738;30084848;30779550;34428180;35984892;36288343;37453647;37712850;37817439;37828378;39627609;7556453;9284967", "class_list": "", "function": "ErbB3 binding protein 1 contributes to adult hippocampal neurogenesis by modulating Bmp4 and Ascl1 signaling., [RefSeq, PubMed]; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES. Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003714 transcription corepressor activity;GO:0031625 ubiquitin protein ligase binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P50580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61364-1", "uniprot_id": "OSTN_MOUSE", "mass": 14438.0, "length": 130, "protein_name": "Osteocrin", "gene_name": "Ostn", "organism": "Mouse", "refseq_name": "osteocrin precursor", "refseq_ac": "NP_932780", "gene_names_uniprotkb": "Ostn", "gene_names_refseq": "Ostc; Ostn", "protein_names_uniprotkb": "Osteocrin; Musclin", "protein_names_refseq": "musclin; osteocrin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:239790)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14523025;15044443;17950246;17951249;26668395;27830782;37047496;37170065;37468484;38232727", "class_list": "", "function": "Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis., [RefSeq, PubMed]; Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells., [RefSeq, PubMed]; Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (PubMed:14523025, PubMed:17951249). Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C (PubMed:26668395). May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (PubMed:15044443)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Musclin expression level is tightly regulated by nutritional changes and its physiological role could be linked to glucose metabolism, [RefSeq, PubMed]; Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice., [RefSeq, PubMed]; Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning. Publication Status: Online-Only, [RefSeq, PubMed]; Osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator, [RefSeq, PubMed]; Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide., [RefSeq, PubMed]; The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149W1", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0007166 cell surface receptor signaling pathway;GO:0030154 cell differentiation;GO:0008217 regulation of blood pressure;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61364-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QNQ6-1", "uniprot_id": "OSBP2_MOUSE", "mass": 101353.0, "length": 908, "protein_name": "Oxysterol-binding protein 2", "gene_name": "Osbp2", "organism": "Mouse", "refseq_name": "oxysterol-binding protein 2 isoform 1", "refseq_ac": "NP_690031", "gene_names_uniprotkb": "Osbp2; orp4", "gene_names_refseq": "1700095P05Rik; C630001G20Rik; Gm244; ORP-4; ORP4L; OSBPL1; Osbp2", "protein_names_uniprotkb": "Oxysterol-binding protein 2", "protein_names_refseq": "oxysterol-binding protein 2 isoform 1", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:74309)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21750661;22517741;24245814;25428506;34428180;35820727;36210013;38236177;40885482", "class_list": "", "function": "Mediates the bidirectional lipid exchange between intracellular compartments and the plasma membrane, delivering cholesterol to the plasma membrane while transferring PI(4,5)P(2) to internal organelles, thereby modulating membrane lipid composition and associated signaling pathways (By similarity). Binds 7-ketocholesterol (By similarity). Acts during spermatid development where its function is required prior to the removal of cytoplasm from the sperm head (PubMed:24245814)., [UniProtKB, PubMed, UniProtKB]; ORP4 is essential for the postmeiotic differentiation of germ cells, [RefSeq, PubMed]; The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF21", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0001669 acrosomal vesicle;GO:0097440 apical dendrite", "go_biological_process": "GO:0006869 lipid transport;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5QNQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQS5-1", "uniprot_id": "PAQR2_MOUSE", "mass": 43981.0, "length": 386, "protein_name": "Adiponectin receptor protein 2", "gene_name": "Adipor2", "organism": "Mouse", "refseq_name": "adiponectin receptor protein 2", "refseq_ac": "NP_932102", "gene_names_uniprotkb": "Adipor2; D6Ucla1e; Parq2", "gene_names_refseq": "1110001I14Rik; ADCR2; Adipor2; D6Ucla1e; Paqr2", "protein_names_uniprotkb": "Adiponectin receptor protein 2; Progestin and adipoQ receptor family member 2; Progestin and adipoQ receptor family member II", "protein_names_refseq": "adiponectin receptor protein 2; progestin and adipoQ receptor family member 2; progestin and adipoQ receptor family member II", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); glucose intolerance (Disease Ontology:DOID:10603); hyperinsulinism (Disease Ontology:DOID:2018); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:68465); (R-MMU-163680)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12802337;17068142;17268472;17327425;19661063;21750661;24742672;25428506;30084848;34428180;38485951;38815796", "class_list": "", "function": "Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17068142, PubMed:17268472, PubMed:17327425, PubMed:24742672). Required for normal body fat and glucose homeostasis (PubMed:17068142, PubMed:17268472, PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake (PubMed:12802337, PubMed:17268472, PubMed:24742672). Has intermediate affinity for globular and full-length adiponectin (PubMed:12802337). Required for normal revascularization after chronic ischemia caused by severing of blood vessels (PubMed:24742672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol., [RefSeq, PubMed]; Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA45;Q8CID6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0055100 adiponectin binding;GO:0038023 signaling receptor activity;GO:0097003 adipokinetic hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007507 heart development;GO:0007584 response to nutrient;GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BQS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XZ4-1", "uniprot_id": "PCDB6_MOUSE", "mass": 84280.0, "length": 772, "protein_name": "Protocadherin beta-6", "gene_name": "Pcdhb6", "organism": "Mouse", "refseq_name": "protocadherin beta-6 precursor", "refseq_ac": "NP_444361", "gene_names_uniprotkb": "Pcdhb6", "gene_names_refseq": "Pcdhb5B; Pcdhb6; PcdhbF", "protein_names_uniprotkb": "Protocadherin beta-6; PCDH-beta-6", "protein_names_refseq": "PCDH-beta-6; protocadherin beta-6 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:93877)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11230163;21750661;27161523", "class_list": "", "function": "Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009988 cell-cell recognition", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91XZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70261-1", "uniprot_id": "PALD_MOUSE", "mass": 96740.0, "length": 859, "protein_name": "Paladin", "gene_name": "Pald1", "organism": "Mouse", "refseq_name": "paladin isoform 1", "refseq_ac": "NP_038781", "gene_names_uniprotkb": "Pald1; Pald", "gene_names_refseq": "MMPAL; Pald1; Pald; mKIAA1274", "protein_names_uniprotkb": "Paladin", "protein_names_refseq": "paladin isoform 1; paladin", "tax_id": 10090, "disease": "", "pathway": " (mmu:27355)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;22354871;29133847;33369848;34428180", "class_list": "", "function": "Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis., [RefSeq, PubMed]; Paladin, a novel putative phosphatase, displays a dynamic expression pattern in the vasculature; During embryonic stages it is broadly expressed in endothelial cells, while in the adult it is selectively expressed in arterial smooth muscle cells, [RefSeq, PubMed]; Study describes the phenotype of Pald1 +/- and Pald1 -/- mice and characterize lung defects linking Pald1 to sex-specific endothelial cell apoptosis, development of emphysema and chronic obstructive pulmonary disease-like changes in females. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66JP9;Q8C2I4", "ec_number_list": "", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70261-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RRE7-1", "uniprot_id": "OTUD4_MOUSE", "mass": 123055.0, "length": 1107, "protein_name": "OTU domain-containing protein 4", "gene_name": "Otud4", "organism": "Mouse", "refseq_name": "OTU domain-containing protein 4 isoform 2", "refseq_ac": "NP_001074633", "gene_names_uniprotkb": "Otud4; Kiaa1046", "gene_names_refseq": "4930431L18Rik; D8Ertd69e; Otud4; mKIAA1046", "protein_names_uniprotkb": "OTU domain-containing protein 4; 3.4.19.12", "protein_names_refseq": "OTU domain-containing protein 4 isoform 2; OTU domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:73945)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "17242355;17947660;19144319;21183079;21750661;25153642;26495903;28528544;29395066;30084848;30410068;31964525;34428180;34887587;35820727;36288343;37162556;37507081", "class_list": "", "function": "Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6., [RefSeq, PubMed]; The authors show an essential role of OTUD4 in virus-triggered signaling and contribute to the understanding of deubiquitination-mediated regulation of innate antiviral responses., [RefSeq, PubMed]; Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNI5;Q80TL3;Q9CUN2", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination;GO:0006307 DNA alkylation repair;GO:0034122 negative regulation of toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "B2RRE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A9Q751-1", "uniprot_id": "PCDP1_MOUSE", "mass": 96956.0, "length": 836, "protein_name": "Cilia- and flagella-associated protein 221", "gene_name": "Cfap221", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 221", "refseq_ac": "NP_001108546", "gene_names_uniprotkb": "Cfap221; Gm101; Pcdp1", "gene_names_refseq": "Cfap221; Gm101; Pcdp1", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 221; Primary ciliary dyskinesia protein 1", "protein_names_refseq": "cilia- and flagella-associated protein 221; primary ciliary dyskinesia protein 1", "tax_id": 10090, "disease": "primary ciliary dyskinesia 55 (Disease Ontology:DOID:0061226)", "pathway": " (mmu:226356)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15613475;18039845;20421426;21750661;32704025", "class_list": "", "function": "Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in cilium morphogenesis., [UniProtKB, PubMed]; Pcdp1 plays an important role in ciliary and flagellar biogenesis and motility sperm flagella and the cilia of respiratory epithelial cells and brain ependymal cells in both mice and humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0002177 manchette", "go_biological_process": "GO:0060271 cilium assembly;GO:0044458 motile cilium assembly;GO:0090660 cerebrospinal fluid circulation;GO:0120197 mucociliary clearance;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A9Q751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88554-1", "uniprot_id": "PARP2_MOUSE", "mass": 63397.0, "length": 559, "protein_name": "Poly [ADP-ribose] polymerase 2", "gene_name": "Parp2", "organism": "Mouse", "refseq_name": "poly [ADP-ribose] polymerase 2 isoform 1", "refseq_ac": "NP_033762", "gene_names_uniprotkb": "Parp2; Adprt2; Adprtl2; Aspartl2", "gene_names_refseq": "ADPRT-2; ARTD2; Adprt2; Adprtl2; Aspartl2; PARP-2; Parp2; mPARP-2; pADPRT-2", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase 2; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 2; ADPRT-2; ARTD2; DNA ADP-ribosyltransferase PARP2; NAD(+) ADP-ribosyltransferase 2; PARP-2; Poly[ADP-ribose] synthase 2; Protein poly-ADP-ribosyltransferase PARP2; mPARP-2; pADPRT-2", "protein_names_refseq": "ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase diphtheria toxin-like 2; DNA ADP-ribosyltransferase PARP2; NAD(+) ADP-ribosyltransferase 2; poly (ADP-ribose) polymerase) 2; poly [ADP-ribose] polymerase 2 isoform 1; poly [ADP-ribose] polymerase 2; poly[ADP-ribose] synthase 2; poly[ADP-ribose] synthetase 2; protein poly-ADP-ribosyltransferase PARP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:11546); (R-MMU-110362); (R-MMU-5685939); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696400)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10338144;10364231;11133988;11948190;12065591;12727891;14739238;18436469;20173027;21750661;25428506;25605945;30084848;34203471;34428180;37188809;37351597", "class_list": "", "function": "Caspase-8 not only triggers and amplifies the apoptotic process at cytoplasmic sites but can also act as an executioner at nuclear levels where it cleaves PARP-2, [RefSeq, PubMed]; PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization. Publication Status: Online-Only, [RefSeq, PubMed]; PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes., [RefSeq, PubMed]; Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:12065591). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:12065591). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (By similarity). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (By similarity). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (By similarity). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains (By similarity). Specifically mediates formation of branched poly-ADP-ribosylation (By similarity). Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99N29", "ec_number_list": "2.4.2.-;5.6.2.3;2.3.2.-;2.4.2.30;3.2.1.143;2.3.2.27;3.1.11.2;3.1.21.-;3.1.-.-;5.6.2.4;2.7.7.7;3.1.11.-;1.14.11.-;2.3.2.23;2.3.2.32;3.6.-.-;2.7.11.22;2.7.11.23;2.7.11.24;4.2.99.18;4.2.99.-;3.6.4.-", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0072572 poly-ADP-D-ribose binding;GO:0003682 chromatin binding;GO:0003684 damaged DNA binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0090734 site of DNA damage", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0006281 DNA repair;GO:0006284 base-excision repair;GO:0006974 DNA damage response;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88622-1", "uniprot_id": "PARG_MOUSE", "mass": 109324.0, "length": 969, "protein_name": "Poly(ADP-ribose) glycohydrolase", "gene_name": "Parg", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Parg", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly(ADP-ribose) glycohydrolase; 3.2.1.143", "protein_names_refseq": "", "tax_id": 10090, "disease": "stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (Disease Ontology:DOID:0070352); brain infarction (Disease Ontology:DOID:3454); borna disease (Disease Ontology:DOID:5154)", "pathway": " (R-MMU-110362)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10449915;17242355;19144319;21183079;21750661;23806337;25153642;28528544;31219806", "class_list": "", "function": "Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80YQ6;Q8CB72", "ec_number_list": "2.4.2.-;2.4.2.30;3.2.1.143;3.1.11.2;3.1.21.-;3.1.-.-;3.5.1.-;3.2.2.-;2.7.7.7;4.2.99.18;4.2.99.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004649 poly(ADP-ribose) glycohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0016045 detection of bacterium;GO:0006974 DNA damage response;GO:0045739 positive regulation of DNA repair;GO:0009225 nucleotide-sugar metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O88622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52946-1", "uniprot_id": "PDX1_MOUSE", "mass": 30999.0, "length": 284, "protein_name": "Pancreas/duodenum homeobox protein 1", "gene_name": "Pdx1", "organism": "Mouse", "refseq_name": "pancreas/duodenum homeobox protein 1", "refseq_ac": "NP_032840", "gene_names_uniprotkb": "Pdx1; Ipf1", "gene_names_refseq": "IDX-1; IPF-1; Ipf1; Mody4; Pdx1; STF-1; pdx-1", "protein_names_uniprotkb": "Pancreas/duodenum homeobox protein 1; IDX-1; IPF-1; Insulin promoter factor 1; Islet/duodenum homeobox 1; STF-1; Somatostatin-transactivating factor 1", "protein_names_refseq": "insulin promoter factor 1, homeodomain transcription factor; islet/duodenum homeobox 1; pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; somatostatin-transactivating factor 1", "tax_id": 10090, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); pancreatic agenesis 1 (Disease Ontology:DOID:0061003); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); maturity-onset diabetes of the young type 4 (Disease Ontology:DOID:0111103); cerebral infarction (Disease Ontology:DOID:3526); placental insufficiency (Disease Ontology:DOID:3891); hyperglycemia (Disease Ontology:DOID:4195); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18609)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11279116;12219087;12831837;15121856;16166097;17052199;20637728;22308370;35820727;36672613;7901001;9710595", "class_list": "glycogene", "function": "Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZB03", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043279 response to alkaloid;GO:0010157 response to chlorate;GO:0033273 response to vitamin;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P52946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58501-1", "uniprot_id": "PAXB1_MOUSE", "mass": 104836.0, "length": 919, "protein_name": "PAX3- and PAX7-binding protein 1", "gene_name": "Paxbp1", "organism": "Mouse", "refseq_name": "PAX3- and PAX7-binding protein 1", "refseq_ac": "NP_080386", "gene_names_uniprotkb": "Paxbp1; Gcfc1; Gcfc", "gene_names_refseq": "1810007M14Rik; C21orf66; Gcfc1; Gcfc; Pax3/7bp; Paxbp1", "protein_names_uniprotkb": "PAX3- and PAX7-binding protein 1; GC-rich sequence DNA-binding factor 1; PAX3/7BP", "protein_names_refseq": "GC-rich sequence DNA-binding factor 1; GC-rich sequence DNA-binding factor homolog; PAX3- and PAX7-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67367)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11707072;21183079;21750661;22862948;33753492;34428180;37404821;38750609;40997131", "class_list": "", "function": "Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20., [UniProtKB, PubMed]; Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells., [RefSeq, PubMed]; Paxbp1 is indispensable for the maintenance of peripheral CD4 T cell homeostasis., [RefSeq, PubMed]; Paxbp1 is indispensable for the survival of CD4 and CD8 double-positive thymocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNN9;Q78XY2;Q8R2W3;Q9CRB7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:1990226 histone methyltransferase binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development;GO:0014842 regulation of skeletal muscle satellite cell proliferation;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P58501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIV7-1", "uniprot_id": "OVOL2_MOUSE", "mass": 30685.0, "length": 274, "protein_name": "Transcription factor Ovo-like 2", "gene_name": "Ovol2", "organism": "Mouse", "refseq_name": "transcription factor Ovo-like 2 isoform A", "refseq_ac": "NP_081200", "gene_names_uniprotkb": "Ovol2; Ovo2; Zfp339; Znf339", "gene_names_refseq": "1700108N11Rik; 1810007D21Rik; M-OVO-A; M-OVO-B; M-OVO; MOVO; Ovo2; Ovol2; Zfp339; movo2", "protein_names_uniprotkb": "Transcription factor Ovo-like 2; Zinc finger OVO2; Zinc finger protein 339; Zinc finger protein mOVO; mOvo2", "protein_names_refseq": "MOVO-B zinc finger protein; MOVO-C zinc finger protein; OVO homolog-like 2; ovo-like 2; transcription factor Ovo-like 2 isoform A; transcription factor Ovo-like 2; zinc finger OVO2; zinc finger protein 339; zinc finger protein mOVO", "tax_id": 10090, "disease": "posterior polymorphous corneal dystrophy 1 (Disease Ontology:DOID:0110855)", "pathway": " (mmu:107586)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12213202;15225875;16423343;23319585;24735878;24735879;25428506;28059165;36228616;38012144;38627980;38833344;9468311", "class_list": "", "function": "Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning., [RefSeq, PubMed]; Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics., [RefSeq, PubMed]; OVOL2 sustains postnatal thymic epithelial cell identity. Publication Status: Online-Only, [RefSeq, PubMed]; Ovol2 transcription was dramatically reduced in testes from blind-sterile mice, suggesting that Ovol2 is expressed in male germ cells, [RefSeq, PubMed]; Zinc-finger transcription repressor factor (PubMed:15225875, PubMed:23319585, PubMed:36228616). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (PubMed:24735878, PubMed:24735879). Positively regulates neuronal differentiation (PubMed:16423343, PubMed:23319585). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (By similarity). Important for the correct development of primordial germ cells in embryos (PubMed:28059165). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (PubMed:36228616)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505Q7;Q6F661;Q8CIV6;Q8K0D6;Q9D949", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001842 neural fold formation;GO:0060214 endocardium formation;GO:0009913 epidermal cell differentiation;GO:0045617 negative regulation of keratinocyte differentiation;GO:2000647 negative regulation of stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CIV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2C7-1", "uniprot_id": "OS9_MOUSE", "mass": 76108.0, "length": 672, "protein_name": "Protein OS-9", "gene_name": "Os9", "organism": "Mouse", "refseq_name": "protein OS-9 isoform 1 precursor", "refseq_ac": "NP_001164497", "gene_names_uniprotkb": "Os9", "gene_names_refseq": "4632413K17Rik; Os9", "protein_names_uniprotkb": "Protein OS-9", "protein_names_refseq": "osteosarcoma amplified 9; protein OS-9 isoform 1 precursor; protein OS-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:216440); (R-MMU-382556); (R-MMU-5358346); (R-MMU-9931269)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10403379;17932042;19084021;21750661;25428506;26721884;30899004;34428180;37828378", "class_list": "glycogene", "function": "Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1) prior to glycosylation/processing., [RefSeq, PubMed]; Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1., [UniProtKB, UniProtKB]; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation., [UniProtKB, UniProtKB]; OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0030246 carbohydrate binding;GO:0140032 glycosylation-dependent protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0000836 Hrd1p ubiquitin ligase complex", "go_biological_process": "GO:0006605 protein targeting;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K2C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PJ1-1", "uniprot_id": "PCD15_MOUSE", "mass": 214738.0, "length": 1943, "protein_name": "Protocadherin-15", "gene_name": "Pcdh15", "organism": "Mouse", "refseq_name": "protocadherin-15 isoform CD1-2 precursor", "refseq_ac": "NP_001136207", "gene_names_uniprotkb": "Pcdh15", "gene_names_refseq": "Gm9815; Pcdh15; Ush1f; av; nmf19; roda", "protein_names_uniprotkb": "Protocadherin-15", "protein_names_refseq": "Ames waltzer; protocadherin 15 CD2; protocadherin-15 isoform CD1-2 precursor", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 23 (Disease Ontology:DOID:0110481); Usher syndrome type 1D (Disease Ontology:DOID:0110831); Usher syndrome type 1F (Disease Ontology:DOID:0110832)", "pathway": " (mmu:11994)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11138007;11429292;16481439;16799054;16807332;17242355;17805295;21436032;21750661;23135401;23217710;25114259;25467981;34428180;38228630;38806495", "class_list": "", "function": "Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function., [UniProtKB]; Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 9, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 3, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "D6RCH0;E9Q7D7;E9Q7R1;E9Q7R2;F6KJX4;F6KKG6;F6R5Z7;F6RBV2;F6U3Q6;F6UPC9;F6VPR3;F6WUN7;F6X715;F6XPA1;F6Y0A5;F6YP25;F6YZQ9;F7ASH0;F7CIN1;F7D5J8;F7DFU0;F8VQ61;H3BKS0;Q0ZM15;Q0ZM16;Q0ZM18;Q0ZM19;Q0ZM20;Q0ZM21;Q0ZM22;Q0ZM23;Q0ZM24;Q0ZM25;Q0ZM26;Q0ZM27;Q0ZM28;Q0ZM29;Q0ZM30;Q0ZM31;Q0ZM32;Q0ZM33;Q0ZM34;Q0ZM35;Q0ZM37;Q2VQG7;Q3URZ1;Q3UTS7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0001964 startle response;GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q99PJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2V4-1", "uniprot_id": "PCKGC_MOUSE", "mass": 69355.0, "length": 622, "protein_name": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "gene_name": "Pck1", "organism": "Mouse", "refseq_name": "phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "refseq_ac": "NP_035174", "gene_names_uniprotkb": "Pck1; Pepck", "gene_names_refseq": "PEPCK-C; PEPCK; Pck-1; Pck1", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; 2.7.11.-; 4.1.1.32; PEPCK-C; Serine-protein kinase PCK1", "protein_names_refseq": "phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; serine-protein kinase PCK1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Alzheimer's disease (Disease Ontology:DOID:10652); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18534); (R-MMU-70263)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10221772;10938127;11792850;11916968;16100117;21183079;29230018;30193097;34428180;37507081;38017546", "class_list": "", "function": "Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:11792850, PubMed:11916968, PubMed:29230018, PubMed:30193097). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (PubMed:29230018). The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (PubMed:29230018). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (By similarity). The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; HnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEH3", "ec_number_list": "4.1.1.32;2.7.11.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0030145 manganese ion binding;GO:0031406 carboxylic acid binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046327 glycerol biosynthetic process from pyruvate;GO:0051365 cellular response to potassium ion starvation;GO:0097403 cellular response to raffinose;GO:0006629 lipid metabolic process;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z2V4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KP6-1", "uniprot_id": "PRP19_MOUSE", "mass": 55239.0, "length": 504, "protein_name": "Pre-mRNA-processing factor 19", "gene_name": "Prpf19", "organism": "Mouse", "refseq_name": "pre-mRNA-processing factor 19 isoform 1", "refseq_ac": "NP_001240772", "gene_names_uniprotkb": "Prpf19; Prp19; Snev", "gene_names_refseq": "D19Wsu55e; NMP200; PSO4; Prp19; Prpf19; Snev", "protein_names_uniprotkb": "Pre-mRNA-processing factor 19; 2.3.2.27; Nuclear matrix protein 200; PRP19/PSO4 homolog; RING-type E3 ubiquitin transferase PRP19; Senescence evasion factor", "protein_names_refseq": "PRP19/PSO4 homolog; PRP19/PSO4 pre-mRNA processing factor 19 homolog; RING-type E3 ubiquitin transferase PRP19; nuclear matrix protein 200; nuclear matrix protein SNEV; pre-mRNA-processing factor 19 isoform 1; prp19 beta; senescence evasion factor", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:28000); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-72163)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "16352598;17118936;17283042;17349974;17964290;20173027;23806337;25428506;25605945;29187734;30084848;34418053;34428180;35820727;37828378;38265236", "class_list": "", "function": "CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection by targeting ORF6 for ubiquitin-dependent degradation., [RefSeq, PubMed]; Down-regulation of Prp19p expression with RNA interference in 3T3-L1 cells repressed lipid droplet formation with the reduction in the level of expression of perilipin and S3-12, [RefSeq, PubMed]; Forced expression leads to suppression of neuronal differentiation, and on the contrary to stimulation of astroglial cell differentiation in retinoic acid-primed P19 cells (PubMed:16352598)., [UniProtKB, PubMed]; Immunofluorescence microscopy revealed that a domain of amino acids 167-250 is necessary for the recruitment of Prp19p to lipid droplets and that a domain of amino acids 1-166 is necessary for the recruitment of Prp19p to a nucleus., [RefSeq, PubMed]; SNEV protein is essential, functionally nonredundant, and indispensable for mouse development. GeneRIF: SNEV is indispensable for early mouse development; MEFs (mouse embryonic fibroblasts) with reduced SNEV levels have lowered proliferative potential., [RefSeq, PubMed]; The alpha-variant of Prp19 gene plays a pivotal role in neural differentiation and that the beta-variant participates in neuronal/astroglial cell fate decisions, [RefSeq, PubMed]; Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries. The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair. Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response. May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA. As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process. In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:17349974). May play a role in the biogenesis of lipid droplets (PubMed:17118936). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP64;Q4ADG5;Q8BKZ5;Q8BVQ4", "ec_number_list": "3.6.4.13;5.2.1.8;3.6.4.-;5.6.2.3;3.1.13.-;2.7.7.48;2.7.7.6;3.1.-.-;6.5.1.1;5.6.2.4;2.7.7.7;3.1.11.-;2.3.2.27;2.3.2.32;3.6.4.10;2.7.11.22;2.7.11.23;2.7.11.24;3.4.19.12", "go_molecular_function": "GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005819 spindle;GO:0016607 nuclear speck", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0008610 lipid biosynthetic process;GO:0045665 negative regulation of neuron differentiation;GO:0045666 positive regulation of neuron differentiation;GO:0000244 spliceosomal tri-snRNP complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q99KP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLR5-1", "uniprot_id": "PSD4_MOUSE", "mass": 112733.0, "length": 1005, "protein_name": "PH and SEC7 domain-containing protein 4", "gene_name": "Psd4", "organism": "Mouse", "refseq_name": "PH and SEC7 domain-containing protein 4", "refseq_ac": "NP_808279", "gene_names_uniprotkb": "Psd4; Efa6b", "gene_names_refseq": "EFA6B; Psd4", "protein_names_uniprotkb": "PH and SEC7 domain-containing protein 4; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B; Exchange factor for ARF6 B; Pleckstrin homology and SEC7 domain-containing protein 4", "protein_names_refseq": "PH and SEC7 domain-containing protein 4; SEC7 homolog; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B; exchange factor for ARF6 B; pleckstrin homology and SEC7 domain-containing protein 4", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:215632)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;34428180", "class_list": "", "function": "Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AIU4;Q3TE33;Q3TQF5;Q3UD59;Q3UFH9;Q80V44", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0030054 cell junction;GO:0032587 ruffle membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BLR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64512-1", "uniprot_id": "PTN13_MOUSE", "mass": 270334.0, "length": 2453, "protein_name": "Tyrosine-protein phosphatase non-receptor type 13", "gene_name": "Ptpn13", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 13", "refseq_ac": "NP_035334", "gene_names_uniprotkb": "Ptpn13; Ptp14", "gene_names_refseq": "PTP-BL; PTPL1; Ptpn13; Ptpri; RIP", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 13; 3.1.3.48; PTP36; Protein tyrosine phosphatase DPZPTP; Protein tyrosine phosphatase PTP-BL; Protein-tyrosine phosphatase RIP", "protein_names_refseq": "PTP36; protein tyrosine phosphatase DPZPTP; protein tyrosine phosphatase PTP-BL; protein-tyrosine phosphatase RIP; tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 13", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:19249); (R-MMU-1660499); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10526152;10826496;15663004;21183079;21750661;22645316;23108400;25428506;28924170;30084848;30189200;31599954;33537085;34428180;7832766;7843407;8074693;8749712;9487134", "class_list": "", "function": "Both in its ligand-free state and when bind to PRK2, PDZ3 of PTPN13 adopts the classical compact, globular D/E fold. PDZ3 of PTPN13 binds five carboxy-terminal amino acids of PRK2 via a groove located between the EB-strand and the DB-helix., [RefSeq, PubMed]; Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy. Publication Status: Online-Only, [RefSeq, PubMed]; Following TBI, calpain-2 activation cleaved PTPN13, activated c-Abl and triggered tau tyrosine phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling., [UniProtKB, UniProtKB]; Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61494;Q62135;Q64499", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.4.17.22;1.2.1.3;1.2.1.94;3.6.5.2;2.7.11.39;2.7.10.1;2.7.3.2;3.6.4.13;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0001933 negative regulation of protein phosphorylation;GO:0006470 protein dephosphorylation;GO:1904890 negative regulation of excitatory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q64512-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1P4-1", "uniprot_id": "PSA1_MOUSE", "mass": 29547.0, "length": 263, "protein_name": "Proteasome subunit alpha type-1", "gene_name": "Psma1", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-1", "refseq_ac": "NP_036095", "gene_names_uniprotkb": "Psma1", "gene_names_refseq": "C2; HC2; Pros-30; Psma1; alpha-type", "protein_names_uniprotkb": "Proteasome subunit alpha type-1; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chain; Proteasome subunit alpha-6; alpha-6", "protein_names_refseq": "20S proteasome subunit C2; alpha-6; macropain subunit C2; multicatalytic endopeptidase complex subunit C2; proteasome (prosome, macropain) subunit, alpha type 1; proteasome component C2; proteasome nu chain; proteasome subunit alpha type-1; proteasome subunit alpha-6", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:26440); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 18, "publication_id_list": "10436176;10873386;12874245;16317774;16581775;16857966;17521679;19526544;21183079;21750661;22341445;22556278;31219806;33725478;34428180;36288343;37453647;37507081", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9R1P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TXS7-1", "uniprot_id": "PSMD1_MOUSE", "mass": 105730.0, "length": 953, "protein_name": "26S proteasome non-ATPase regulatory subunit 1", "gene_name": "Psmd1", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 1", "refseq_ac": "NP_081633", "gene_names_uniprotkb": "Psmd1", "gene_names_refseq": "2410026J11Rik; P112; Psmd1; S1", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70247); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16487046;16857966;17242355;19131326;21183079;21750661;23806337;26495903;28011936;30084848;31219806;34203471;34428180;36210013;37507081;37828378;39627609", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB]; In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a self-compartmentalizing protease comprised of approximately 31 different subunits. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. Protein degradation by proteasomes is the source of most antigenic peptides presented on MHC class I molecules. This gene encodes a non-ATPase subunit of the 26S proteasome. [provided by RefSeq, Jul 2008]., [RefSeq]; Individual proteasome subunits are important for the regulation of age-related changes in both proteasome activity and protein oxidation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RRP8", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0042176 regulation of protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q3TXS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JF8-1", "uniprot_id": "PSIP1_MOUSE", "mass": 59697.0, "length": 528, "protein_name": "PC4 and SFRS1-interacting protein", "gene_name": "Psip1", "organism": "Mouse", "refseq_name": "PC4 and SFRS1-interacting protein isoform 2", "refseq_ac": "NP_001277456", "gene_names_uniprotkb": "Psip1; Ledgf", "gene_names_refseq": "Dfs70; Ledgfa; Ledgfb; Psip1; Psip2", "protein_names_uniprotkb": "PC4 and SFRS1-interacting protein; Lens epithelium-derived growth factor; mLEDGF", "protein_names_refseq": "PC4 and SFRS1 interacting protein 2; PC4 and SFRS1-interacting protein isoform 2; PC4 and SFRS1-interacting protein; dense fine speckles 70; lens epithelium-derived growth factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:101739); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15238362;16452087;17242355;19131326;19144319;21183079;21750661;24463520;28135057;28528544;33477970;34428180;37507081", "class_list": "", "function": "LEDGF is one of the transcriptional activators of these genes that facilitates cellular protection against ethanol stress and plays a role in retinoic acid production. GeneRIF: Alcohol (ADH) and ALDH dehydrogenases are implicated in cellular detoxification and conversion of vitamin A to RA. Lens epithelium-derived growth factor provides cellular protection against stress by transactivating stress-associated genes., [RefSeq, PubMed]; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity)., [UniProtKB, UniProtKB]; Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BI10;A2BI11;Q3TEJ7;Q3TTD7;Q3UTA1;Q80WQ7;Q99JF7;Q99LR4;Q9CT03", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0097100 supercoiled DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000791 euchromatin;GO:0034399 nuclear periphery;GO:0000792 heterochromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99JF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SW1-1", "uniprot_id": "SAHH2_MOUSE", "mass": 58951.0, "length": 530, "protein_name": "S-adenosylhomocysteine hydrolase-like protein 1", "gene_name": "Ahcyl1", "organism": "Mouse", "refseq_name": "S-adenosylhomocysteine hydrolase-like protein 1 isoform 1", "refseq_ac": "NP_663517", "gene_names_uniprotkb": "Ahcyl1; Irbit", "gene_names_refseq": "1110034F20Rik; Ahcy-rs3; Ahcyl1; DCAL; Irbit", "protein_names_uniprotkb": "S-adenosylhomocysteine hydrolase-like protein 1; AdoHcyase 2; IP3R-binding protein released with inositol 1,4,5-trisphosphate; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2", "protein_names_refseq": "IP3R binding protein released with inositol 1,4,5-trisphosphate; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase, related sequence 3; S-adenosylhomocysteine hydrolase-like protein 1 isoform 1; S-adenosylhomocysteine hydrolase-like protein 1; adoHcyase 2; putative adenosylhomocysteinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:229709); (R-MMU-5578775)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11904675;12525476;16527252;16769890;17242355;17635105;19033647;19220705;19224921;21183079;21317537;21750661;23542070;23806337;26509711;31219806;33727633;35351819;37828378", "class_list": "", "function": "Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO3(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2. Publication Status: Online-Only, [RefSeq, PubMed]; IRBIT can directly interact with the IP3R, and that both the suppressor domain and the IP3-binding core of the IP3R are essential for a strong interaction., [RefSeq, PubMed]; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (By similarity). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (By similarity). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (PubMed:12525476, PubMed:23542070). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:19224921). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (PubMed:19033647, PubMed:21317537). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2. Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (By similarity). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (PubMed:12525476). Functions as a SAH (S-adenosyl-L-homocysteine) sensor that inhibits autophagy through an MTORC1-independent mechanism. Upon SAH binding, interacts with the catalytic domain of PIK3C3, inhibiting its lipid kinase activity and reducing production of phosphatidylinositol-3-phosphate (PtdIns3P), thereby blocking autophagosome formation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP3 (IRBIT). Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0043231 intracellular membrane-bounded organelle;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042045 epithelial fluid transport;GO:0051592 response to calcium ion;GO:0006915 apoptotic process;GO:0038166 angiotensin-activated signaling pathway;GO:0006730 one-carbon metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80SW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70398-1", "uniprot_id": "USP9X_MOUSE", "mass": 290711.0, "length": 2559, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 9X", "gene_name": "Usp9x", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 9X isoform 1", "refseq_ac": "NP_033507", "gene_names_uniprotkb": "Usp9x; Fafl; Fam", "gene_names_refseq": "5730589N07Rik; Dffrx; FAF-X; Fafl; Usp9x", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 9X; 3.4.19.12; Deubiquitinating enzyme FAF-X; Fat facets homolog; Fat facets protein-related, X-linked; Ubiquitin carboxyl-terminal hydrolase FAM; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X", "protein_names_refseq": "deubiquitinating enzyme FAF-X; fat facets homolog; fat facets protein-related, X-linked; fats facets protein related, X; probable ubiquitin carboxyl-terminal hydrolase FAF-X; ubiquitin carboxyl-terminal hydrolase 9X isoform 1; ubiquitin carboxyl-terminal hydrolase 9X; ubiquitin carboxyl-terminal hydrolase FAM; ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-processing protease FAF-X", "tax_id": 10090, "disease": "female-restricted syndromic X-linked intellectual disability 99 (Disease Ontology:DOID:0112025); non-syndromic X-linked intellectual disability 99 (Disease Ontology:DOID:0112026)", "pathway": " (mmu:22284); (R-MMU-2173795); (R-MMU-5689880); (R-MMU-8866652); (R-MMU-9013420); (R-MMU-9013424); (R-MMU-9033241)", "pathway_count": 7, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;12895410;17242355;17947660;21183079;21750661;22645316;24607389;25428506;26495903;29626158;30084848;30779550;30951545;31219806;32848054;33300544;33378666;34203471;34428180;35820727;36210013;36653359;37507081;38878321;40885482;9119401;9178254", "class_list": "", "function": "Circ-USP9X accelerates deep vein thrombosis after fracture by acting as a miR-148b-3p sponge and upregulates SRC kinase signaling inhibitor 1. Publication Status: Online-Only, [RefSeq, PubMed]; Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:12895410, PubMed:29626158, PubMed:30951545). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:29626158, PubMed:30951545). Specifically hydrolyzes 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'-linked polyubiquitins chains (By similarity). Essential component of TGF-beta/BMP signaling cascade (By similarity). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (By similarity). Deubiquitinates alkylation repair enzyme ALKBH3 (By similarity). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity). Deubiquitinates RNA demethylase enzyme ALKBH5, promoting its stability (By similarity). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (By similarity). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (By similarity). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (By similarity). Deubiquitinates PEG10 (PubMed:30951545). Inhibits the activation of the Hippo signaling pathway via deubiquitination of AMOTL2 at 'Lys-337' and 'Lys-404' which prohibits its interaction with and activation of LATS2. Loss of LATS2 activation and subsequent loss of YAP1 phosphorylation results in an increase in YAP1-driven transcription of target genes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QLY0;Q62497", "ec_number_list": "2.7.11.1;3.6.5.2;3.4.19.12;2.7.10.1;2.3.2.27;2.7.11.25;2.3.2.26;2.7.10.2", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0001701 in utero embryonic development;GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P70398-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3Z5-1", "uniprot_id": "CACB1_MOUSE", "mass": 65486.0, "length": 597, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-1", "gene_name": "Cacnb1", "organism": "Mouse", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-1 isoform C", "refseq_ac": "NP_001152791", "gene_names_uniprotkb": "Cacnb1; Cacnlb1", "gene_names_refseq": "CAB1; Cacnb1; Cchb1; Cchlb1", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-1; CAB1; Calcium channel voltage-dependent subunit beta 1", "protein_names_refseq": "calcium channel voltage-dependent subunit beta 1; voltage-dependent L-type calcium channel subunit beta-1 isoform C; voltage-dependent L-type calcium channel subunit beta-1; voltage-dependent calcium channel beta1 subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:12295); (R-MMU-112308); (R-MMU-5576892); (R-MMU-5576893)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "1385409;14500989;16452087;16638807;21183079;21320436;21750661;21831364;24751537;28351836;33300544;39927985", "class_list": "", "function": "Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A544;O88517;Q7TPF2;Q8R3Z6;Q9EPT9", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005246 calcium channel regulator activity;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0016529 sarcoplasmic reticulum;GO:0030315 T-tubule", "go_biological_process": "GO:0045933 positive regulation of muscle contraction;GO:1904646 cellular response to amyloid-beta;GO:0006612 protein targeting to membrane;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R3Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBQ7-1", "uniprot_id": "PACE1_MOUSE", "mass": 81333.0, "length": 735, "protein_name": "Protein-associating with the carboxyl-terminal domain of ezrin", "gene_name": "Scyl3", "organism": "Mouse", "refseq_name": "protein-associating with the carboxyl-terminal domain of ezrin isoform 2", "refseq_ac": "NP_001272931", "gene_names_uniprotkb": "Scyl3; Pace1", "gene_names_refseq": "1200016D23Rik; 6030457O16; Pace1; Scyl3", "protein_names_uniprotkb": "Protein-associating with the carboxyl-terminal domain of ezrin; Ezrin-binding protein PACE-1; SCY1-like protein 3", "protein_names_refseq": "SCY1-like protein 3; ezrin-binding partner PACE-1; ezrin-binding protein PACE-1; protein-associating with the carboxyl-terminal domain of ezrin isoform 2; protein-associating with the carboxyl-terminal domain of ezrin", "tax_id": 10090, "disease": "", "pathway": " (mmu:240880)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;29437892;34428180", "class_list": "", "function": "May play a role in regulating cell adhesion/migration complexes in migrating cells., [UniProtKB]; SCYL1 and SCYL3 play overlapping roles in maintaining motor neuronal viability in vivo and confirm that SCYL family members are critical regulators of neuronal function and survival, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRA7;Q6NY01;Q8BQC9;Q8BRJ1", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0021522 spinal cord motor neuron differentiation;GO:0008104 intracellular protein localization;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DBQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLM9-1", "uniprot_id": "GRB14_MOUSE", "mass": 60573.0, "length": 538, "protein_name": "Growth factor receptor-bound protein 14", "gene_name": "Grb14", "organism": "Mouse", "refseq_name": "growth factor receptor-bound protein 14 isoform 1", "refseq_ac": "NP_057928", "gene_names_uniprotkb": "Grb14", "gene_names_refseq": "Grb14", "protein_names_uniprotkb": "Growth factor receptor-bound protein 14; GRB14 adapter protein", "protein_names_refseq": "GRB14 adapter protein; growth factor receptor-bound protein 14 isoform 1", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:50915); (R-MMU-210993)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10521483;10713090;14749734;15059968;17242355;21183079;21750661;32099031;33921658", "class_list": "", "function": "Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity)., [UniProtKB]; Grb14 functions in vivo as a tissue-specific modulator of insulin action, most likely via repression of IR-mediated IRS-1 tyrosine phosphorylation, [RefSeq, PubMed]; Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of Grb14 expression in adipose tissue may play a physiological role in insulin sensitivity, [RefSeq, PubMed]; Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI77;Q8VDI2;Q9CR03", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0051219 phosphoprotein binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JLM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBU6-1", "uniprot_id": "RSRC1_MOUSE", "mass": 38637.0, "length": 334, "protein_name": "Serine/Arginine-related protein 53", "gene_name": "Rsrc1", "organism": "Mouse", "refseq_name": "serine/Arginine-related protein 53 isoform 2", "refseq_ac": "NP_080098", "gene_names_uniprotkb": "Rsrc1; Srrp53", "gene_names_refseq": "1200013F24Rik; Rsrc1; SRrp53", "protein_names_uniprotkb": "Serine/Arginine-related protein 53; Arginine/serine-rich coiled-coil protein 1; SRrp53", "protein_names_refseq": "arginine/serine-rich coiled-coil protein 1; serine/Arginine-related protein 53 isoform 2; serine/Arginine-related protein 53", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 70 (Disease Ontology:DOID:0081231)", "pathway": " (mmu:66880)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15798186;21750661;40997131", "class_list": "", "function": "Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity)., [UniProtKB]; SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF06", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0008380 RNA splicing;GO:0046677 response to antibiotic;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DBU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46460-1", "uniprot_id": "NSF_MOUSE", "mass": 82613.0, "length": 744, "protein_name": "Vesicle-fusing ATPase", "gene_name": "Nsf", "organism": "Mouse", "refseq_name": "vesicle-fusing ATPase", "refseq_ac": "NP_032766", "gene_names_uniprotkb": "Nsf; Skd2", "gene_names_refseq": "Nsf; SKD2", "protein_names_uniprotkb": "Vesicle-fusing ATPase; 3.6.4.6; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; Protein SKD2; Suppressor of K(+) transport growth defect 2; Vesicular-fusion protein NSF", "protein_names_refseq": "N-ethylmaleimide sensitive factor; NEM-sensitive fusion protein; suppressor of K(+) transport growth defect 2; vesicle-fusing ATPase; vesicular-fusion protein NSF", "tax_id": 10090, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 96 (Disease Ontology:DOID:0070377); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:18195); (R-MMU-204005); (R-MMU-416993); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16461345;18034455;18272689;21183079;21750661;23806337;25605945;26740625;30084848;32152506;33300544;34428180;37507081;38395304;39627609;40684658;8082782", "class_list": "", "function": "Munc18c accelerates SNARE-dependent membrane fusion in the presence of regulatory proteins alpha-SNAP and NSF., [RefSeq, PubMed]; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack GRIA2 leads to influence GRIA2 membrane cycling (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A646;Q8BQ65;Q8C3R2;Q8CCT9;Q8CEF0;Q923C6", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;2.3.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0051260 protein homooligomerization;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P46460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80U30-1", "uniprot_id": "CL16A_MOUSE", "mass": 116232.0, "length": 1036, "protein_name": "Protein CLEC16A", "gene_name": "Clec16a", "organism": "Mouse", "refseq_name": "protein CLEC16A isoform 2", "refseq_ac": "NP_001191158", "gene_names_uniprotkb": "Clec16a; Kiaa0350", "gene_names_refseq": "4932416N17Rik; Clec16a; curt; mKIAA0350", "protein_names_uniprotkb": "Protein CLEC16A", "protein_names_refseq": "protein CLEC16A isoform 2; protein CLEC16A", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Addison's disease (Disease Ontology:DOID:13774); multiple sclerosis (Disease Ontology:DOID:2377); rheumatoid arthritis (Disease Ontology:DOID:7148); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:74374)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19855005;21750661;24949970;25428506;25891430;31361958;34428180", "class_list": "", "function": "CLEC16A associations in common variable immunodeficiency disorder represent the first robust evidence of non-HLA associations in this immunodeficiency condition. Publication Status: Online-Only, [RefSeq, PubMed]; Islets from mice with pancreas-specific deletion of Clec16a have abnormal mitochondria with reduced oxygen consumption and ATP concentration, both of which are required for normal beta cell function, Clec16a controls beta cell function and prevents diabetes by controlling mitophagy., [RefSeq, PubMed]; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6X932;B2RSL3;Q3TCF2;Q3U0F5;Q3U2F6;Q8CEQ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031982 vesicle;GO:0036020 endolysosome membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:1901097 negative regulation of autophagosome maturation;GO:1901525 negative regulation of mitophagy;GO:1904263 positive regulation of TORC1 signaling;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80U30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLY0-1", "uniprot_id": "SOCS6_MOUSE", "mass": 59077.0, "length": 533, "protein_name": "Suppressor of cytokine signaling 6", "gene_name": "Socs6", "organism": "Mouse", "refseq_name": "suppressor of cytokine signaling 6", "refseq_ac": "NP_061291", "gene_names_uniprotkb": "Socs6; Cis4; Cish4; Socs4", "gene_names_refseq": "1500012M23Rik; 5830401B18Rik; Cis4; Cish4; HSPC060; SOCS-4; SOCS-6; SSI4; STAI4; STATI4; Socs4; Socs6", "protein_names_uniprotkb": "Suppressor of cytokine signaling 6; CIS-4; Cytokine-inducible SH2 protein 4; SOCS-4; SOCS-6; Suppressor of cytokine signaling 4", "protein_names_refseq": "CIS-4; SH2 domain containing SOCS box protein SOCS6; cytokine inducible SH2-containing protein 4; cytokine inducible SH2-containing protein CIS4; cytokine-inducible SH2 protein 4; suppressor of cytokine signaling 4; suppressor of cytokine signaling 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:54607); (R-MMU-8951664); (R-MMU-9706369)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "12052866;12396724;14707129;15123678;16643902;21099329;21750661;24284072;26503265;31219806;34428180;35126805", "class_list": "", "function": "Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6, [RefSeq, PubMed]; Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling 'ON' and 'OFF' drive the fundamentally cyclic process of cell migration in the cortex., [RefSeq, PubMed]; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity)., [UniProtKB, PubMed]; SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6), [RefSeq, PubMed]; SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase, [RefSeq, PubMed]; SOCS4 expression, in contrast, does not appear to be EPO inducible.SOCS4 is ineffective at counteracting EPO-mediated events., [RefSeq, PubMed]; SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte Apoptosis and Is Negatively Regulated by Quaking-Mediated miR-19b. Publication Status: Online-Only, [RefSeq, PubMed]; SOCS6 has a role as a negative regulator of receptor tyrosine kinases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEN5;Q9D2A0", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0001772 immunological synapse", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0040008 regulation of growth;GO:0016567 protein ubiquitination;GO:0009968 negative regulation of signal transduction;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TEI4-1", "uniprot_id": "CO039_MOUSE", "mass": 108224.0, "length": 1023, "protein_name": "Uncharacterized protein C15orf39 homolog", "gene_name": "1700017B05Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C15orf39 homolog", "refseq_ac": "NP_083096", "gene_names_uniprotkb": "1700017B05Rik", "gene_names_refseq": "1700017B05Rik; D9Ertd278e; Prmt2ip", "protein_names_uniprotkb": "Uncharacterized protein C15orf39 homolog", "protein_names_refseq": "uncharacterized protein C15orf39 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74211)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;21183079;21750661;31219806;32782141;34428180;36852467", "class_list": "", "function": "Negatively regulates microglial inflammatory responses. Inhibits NF-kappa-B signaling by interacting with PRMT2, thereby reducing the production of pro-inflammatory cytokines, maintaining a steady-state in microglia and limiting excessive inflammation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q148A1;Q3TMF2;Q3U253;Q3UM75;Q9DA93", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0050728 negative regulation of inflammatory response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3TEI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60597-1", "uniprot_id": "ODO1_MOUSE", "mass": 116449.0, "length": 1023, "protein_name": "2-oxoglutarate dehydrogenase complex component E1", "gene_name": "Ogdh", "organism": "Mouse", "refseq_name": "2-oxoglutarate dehydrogenase complex component E1 isoform 1", "refseq_ac": "NP_001239211", "gene_names_uniprotkb": "Ogdh; Kiaa4192", "gene_names_refseq": "2210403E04Rik; 2210412K19Rik; E1o; OGDH-E1; Ogdh; d1401; mKIAA4192", "protein_names_uniprotkb": "2-oxoglutarate dehydrogenase complex component E1; 1.2.4.2; 2-oxoglutarate dehydrogenase, mitochondrial; Alpha-KGDH-E1; Alpha-ketoglutarate dehydrogenase; E1o; OGDC-E1; OGDH-E1; Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase", "protein_names_refseq": "2-oxoglutarate dehydrogenase complex component E1 isoform 1; 2-oxoglutarate dehydrogenase complex component E1; 2-oxoglutarate dehydrogenase, mitochondrial; OGDC-E1; alpha-KGDH-E1; alpha-ketoglutarate dehydrogenase; oxoglutarate dehydrogenase (lipoamide); thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase", "tax_id": 10090, "disease": "Yoon-Bellen neurodevelopmental syndrome (Disease Ontology:DOID:0070468); oxoglutarate dehydrogenase deficiency (Disease Ontology:DOID:0081326); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:18293); (R-MMU-6783984); (R-MMU-9837999); (R-MMU-9853506)", "pathway_count": 4, "publication_count": 43, "publication_id_list": "10755612;10770802;11172018;11207252;12469116;12707327;14978103;1606619;16424178;17418792;17670943;18941216;18973345;19755422;20007535;20173027;21183079;21750661;22101157;22233579;23576753;23806337;26523866;30084848;30779550;34428180;35820727;36288343;36854377;37453647;37507081;38956325;39627609;39927985;7544375;7972088;7972089;8084337;8248240;8752916;9130638;9391114;9551915", "class_list": "", "function": "2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC. Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Can also convert 2-keto-4-hydroxyglutarate (KHG) and CoA into malyl-CoA. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDM7;Q5DTI4;Q5SVX7;Q5SVX9;Q6PFZ2;Q80Y57;Q8K0K7;Q8K2Z3;Q8R3M2;Q91WP2", "ec_number_list": "3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;3.1.2.-;3.1.2.2;3.4.21.92;1.1.1.37;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;1.1.1.42;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;1.1.1.30;2.7.11.2;6.1.1.5;2.7.1.23;3.4.21.53;5.6.2.3;2.3.1.9;2.3.1.37;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.61;2.3.1.41;1.1.1.41;1.3.8.5;1.3.8.1;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0030976 thiamine pyrophosphate binding;GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0061034 olfactory bulb mitral cell layer development;GO:0006091 generation of precursor metabolites and energy;GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006104 succinyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q60597-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14206-1", "uniprot_id": "RSSA_MOUSE", "mass": 32838.0, "length": 295, "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "Rpsa", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS2", "refseq_ac": "NP_035159", "gene_names_uniprotkb": "Rpsa; Lamr1; P40-8", "gene_names_refseq": "67kDa; 67lr; Lamr1; Lamrl1; Lamr; MLR; P40-3; P40-8; P40; Rpsa", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2; 37 kDa laminin receptor precursor; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; LamR; Laminin receptor 1; Laminin-binding protein precursor p40; OFA/iLRP", "protein_names_refseq": "37 kDa laminin receptor; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; OFA/iLRP; P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA); laminin-binding protein precursor p40; small ribosomal subunit protein uS2", "tax_id": 10090, "disease": "arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); sciatic neuropathy (Disease Ontology:DOID:11446); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:16785); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 27, "publication_id_list": "10697612;11597123;11689427;1374897;15592455;16453457;18339329;20173027;21750661;23806337;2531008;25605945;31219806;3357791;34428180;35820727;35984892;36210013;36288343;37453647;37507081;37828378;38114488;39627609;6301485;6302102;8954992", "class_list": "", "function": "Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response. Erratum:[Nat Commun. 2024 Jan 29;15(1):855. doi: 10.1038/s41467-024-45275-2. PMID: 38287017] Publication Status: Online-Only, [RefSeq, PubMed]; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10., [UniProtKB, PubMed, PubMed, PubMed, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58E74;Q8BHL0;Q8BNL2;Q91V31;Q9CY13", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0043236 laminin binding;GO:0043022 ribosome binding;GO:0005055 laminin receptor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P14206-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88998-1", "uniprot_id": "NOE1_MOUSE", "mass": 55398.0, "length": 485, "protein_name": "Noelin", "gene_name": "Olfm1", "organism": "Mouse", "refseq_name": "noelin isoform b precursor", "refseq_ac": "NP_001033701", "gene_names_uniprotkb": "Olfm1; Noe1; Noel1; Noel", "gene_names_refseq": "AMY; Noe1; OlfA; Olfm1; Pancortin3; Pancortin", "protein_names_uniprotkb": "Noelin; Neuronal olfactomedin-related ER localized protein; Olfactomedin-1; Pancortin", "protein_names_refseq": "Noelin 1; Noelin 2; Pancortin 1-4; neuronal olfactomedin-related ER localized protein; noelin isoform b precursor; olfactomedin related ER localized protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56177)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12385760;17265465;21228389;21750661;22632720;22923615;25903135;26107991;26740625;30899004;32462291;33300544;9473566", "class_list": "", "function": "Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (PubMed:22923615). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (PubMed:26107991)., [UniProtKB, UniProtKB, PubMed, PubMed]; Roles of Olfactomedin 1 in Muscle and Bone Alterations Induced by Gravity Change in Mice., [RefSeq, PubMed]; Study of noelin expression during mouse development, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 20, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A3KGE5;O35429;O88999;Q91XK8;Q9QWQ9;Q9QWR0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "O88998-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N57-1", "uniprot_id": "RAF1_MOUSE", "mass": 72917.0, "length": 648, "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "Raf1", "organism": "Mouse", "refseq_name": "RAF proto-oncogene serine/threonine-protein kinase isoform 1", "refseq_ac": "NP_084056", "gene_names_uniprotkb": "Raf1; Craf", "gene_names_refseq": "6430402F14Rik; Craf1; D830050J10Rik; Raf-1; Raf1; c-Raf; cRaf; v-Raf", "protein_names_uniprotkb": "RAF proto-oncogene serine/threonine-protein kinase; 2.7.11.1; Proto-oncogene c-RAF; Raf-1; cRaf", "protein_names_refseq": "Craf1 transforming; RAF proto-oncogene serine/threonine-protein kinase isoform 1; RAF proto-oncogene serine/threonine-protein kinase; murine sarcoma 3611 oncogene 1; proto-oncogene c-RAF; v-raf-leukemia viral oncogene 1", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); Noonan syndrome 5 (Disease Ontology:DOID:0060583); Noonan syndrome with multiple lentigines 2 (Disease Ontology:DOID:0080549); dilated cardiomyopathy 1NN (Disease Ontology:DOID:0110432); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); Noonan syndrome (Disease Ontology:DOID:3490); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); pancreatic carcinoma (Disease Ontology:DOID:4905)", "pathway": " (mmu:110157); (R-MMU-2672351); (R-MMU-392517); (R-MMU-430116); (R-MMU-5621575); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5674499); (R-MMU-5675221); (R-MMU-9732724)", "pathway_count": 10, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;10862777;11262401;11597136;11716471;11997508;12604616;12675918;15026317;15238444;15379891;15664191;15753127;17242355;1741164;18706973;1886707;18922468;19298812;20926779;21183079;21750661;21926268;22081024;22826029;23509299;28210689;30127380;34428180;37625265;38117455;40128797;7692235;8288587;8321321;8876196", "class_list": "", "function": "Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Regulates Rho signaling and migration, and is required for normal wound healing., [UniProtKB, UniProtKB, PubMed]; Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model., [RefSeq, PubMed]; Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR68;Q58E75;Q91WH1;Q99N58;Q9QUU8", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;3.6.5.2;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.6.4.-;3.1.3.53;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.3.2.26;2.3.2.36;2.7.11.38;3.6.1.-;2.3.2.27;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0030878 thyroid gland development;GO:0038127 ERBB signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q99N57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6T0-1", "uniprot_id": "NOSIP_MOUSE", "mass": 33209.0, "length": 301, "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "Nosip", "organism": "Mouse", "refseq_name": "nitric oxide synthase-interacting protein isoform 2", "refseq_ac": "NP_001157156", "gene_names_uniprotkb": "Nosip", "gene_names_refseq": "2310061K06Rik; CGI-25; Nosip", "protein_names_uniprotkb": "Nitric oxide synthase-interacting protein; 2.3.2.27; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP", "protein_names_refseq": "E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP; nitric oxide synthase-interacting protein isoform 2", "tax_id": 10090, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:66394); (R-MMU-203754)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;18299400;19224205;19892989;20173027;21750661;21952136;25428506;25428507;25546391;25605945;26495903;28011936;28663132;30084848;31599954;34428180;35820727;37828378", "class_list": "", "function": "E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (PubMed:25546391). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; NOSIP mediates the monoubiquitination of the PP2A catalytic subunit and the loss of NOSIP results in an increase in PP2A activity in craniofacial tissue in NOSIP knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; Nosip is a novel factor critical for neural stem cell/progenitor self-renewal and neurogenesis during mouse and Xenopus development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8J9", "ec_number_list": "1.14.13.39;2.3.2.27", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043086 negative regulation of catalytic activity;GO:0016567 protein ubiquitination;GO:0051001 negative regulation of nitric-oxide synthase activity;GO:0045428 regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9D6T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62376-1", "uniprot_id": "RU17_MOUSE", "mass": 51992.0, "length": 448, "protein_name": "U1 small nuclear ribonucleoprotein 70 kDa", "gene_name": "Snrnp70", "organism": "Mouse", "refseq_name": "U1 small nuclear ribonucleoprotein 70 kDa", "refseq_ac": "NP_033250", "gene_names_uniprotkb": "Snrnp70; Snrp70", "gene_names_refseq": "2700022N21Rik; 3200002N22Rik; Rnu1p70; Rnulp70; Snrnp70; Snrp70; Srnp70; U1-70K; U1-70", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; snRNP70", "protein_names_refseq": "U1 small nuclear ribonucleoprotein 70 kDa polypeptide A; U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); disease of mental health (Disease Ontology:DOID:150); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:20637); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "15345747;17242355;17656373;21183079;21750661;2525092;25428506;25605945;30084848;30767021;30779550;31219806;32915994;34428180;39627609;7505633", "class_list": "", "function": "Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dissection of FUS domains involved in regulation of SnRNP70 gene expression., [RefSeq, PubMed]; SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing., [RefSeq, PubMed]; This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]; Truncated isoforms that lack the RRM domain cannot bind U1-snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIW4", "ec_number_list": "", "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:1904715 negative regulation of chaperone-mediated autophagy;GO:0071300 cellular response to retinoic acid;GO:0071560 cellular response to transforming growth factor beta stimulus;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q62376-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPR4-1", "uniprot_id": "S23A2_MOUSE", "mass": 70049.0, "length": 648, "protein_name": "Solute carrier family 23 member 2", "gene_name": "Slc23a2", "organism": "Mouse", "refseq_name": "solute carrier family 23 member 2 isoform a", "refseq_ac": "NP_061294", "gene_names_uniprotkb": "Slc23a2; Kiaa0238; Svct2; Yspl2", "gene_names_refseq": "NBTL1; SVCT2; Slc23a1; Slc23a2; YSPL2; YSPL3; mKIAA0238", "protein_names_uniprotkb": "Solute carrier family 23 member 2; Na(+)/L-ascorbic acid transporter 2; SVCT-2; Sodium-dependent vitamin C transporter 2; Yolk sac permease-like molecule 2; mSVCT2", "protein_names_refseq": "Na(+)/L-ascorbic acid transporter 2; SVCT-2; mSVCT2; sodium-dependent vitamin C transporter 2; solute carrier family 23 (nucleobase transporters), member 1; solute carrier family 23 member 2 isoform a; solute carrier family 23 member 2; yolk sac permease-like molecule 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:54338); (R-MMU-196836)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11214969;17689499;19144319;21183079;21750661;25428506;26740625;30084848;34428180;38180226;38972487", "class_list": "", "function": "Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages., [RefSeq, PubMed]; Modulation of microglia activation by the ascorbic acid transporter SVCT2., [RefSeq, PubMed]; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9420, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y23;Q8C327;Q9JM78", "ec_number_list": "", "go_molecular_function": "GO:0008520 L-ascorbate:sodium symporter activity;GO:0015229 L-ascorbic acid transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0015882 L-ascorbic acid transmembrane transport;GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0008015 blood circulation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9EPR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97445-1", "uniprot_id": "CAC1A_MOUSE", "mass": 267647.0, "length": 2368, "protein_name": "Voltage-dependent P/Q-type calcium channel subunit alpha-1A", "gene_name": "Cacna1a", "organism": "Mouse", "refseq_name": "voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 1", "refseq_ac": "NP_031604", "gene_names_uniprotkb": "Cacna1a; Caca1a; Cach4; Cacn3; Cacnl1a4; Ccha1a", "gene_names_refseq": "APCA; BI; Caca1a; Cacna1a; Cacnl1a4; Cav2.1; Ccha1a; EA2; FHM; HPCA; MHP1; MHP; SCA6; alpha1A; la; nmf352; rkr; smrl; tg", "protein_names_uniprotkb": "Voltage-dependent P/Q-type calcium channel subunit alpha-1A; BI; Brain calcium channel I; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1", "protein_names_refseq": "brain calcium channel I; calcium channel, L type, alpha-1 polypeptide; leaner; rocker; tottering; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 1; voltage-dependent P/Q-type calcium channel subunit alpha-1A; voltage-gated calcium channel subunit alpha Cav2.1", "tax_id": 10090, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); childhood electroclinical syndrome (Disease Ontology:DOID:0050704); cerebellar ataxia (Disease Ontology:DOID:0050753); generalized dystonia (Disease Ontology:DOID:0050835); hereditary ataxia (Disease Ontology:DOID:0050951); spinocerebellar ataxia 6 (Disease Ontology:DOID:0050956); episodic ataxia type 2 (Disease Ontology:DOID:0050990); familial hemiplegic migraine (Disease Ontology:DOID:0060178); absence epilepsy (Disease Ontology:DOID:0070309); developmental and epileptic encephalopathy 42 (Disease Ontology:DOID:0080454); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); migraine with aura (Disease Ontology:DOID:10024); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); generalized epilepsy (Disease Ontology:DOID:1827); temporal lobe epilepsy (Disease Ontology:DOID:3328); migraine (Disease Ontology:DOID:6364)", "pathway": " (mmu:12286); (R-MMU-112308); (R-MMU-422356)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16452087;17114649;21183079;21750661;22645316;35820727;40885482;8929530", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 17, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q2TPN3", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0019905 syntaxin binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0048787 presynaptic active zone membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060024 rhythmic synaptic transmission;GO:0050770 regulation of axonogenesis;GO:0030644 intracellular chloride ion homeostasis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CAK1-1", "uniprot_id": "CAF17_MOUSE", "mass": 38399.0, "length": 358, "protein_name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "gene_name": "Iba57", "organism": "Mouse", "refseq_name": "iron-sulfur cluster assembly factor IBA57, mitochondrial isoform 1 precursor", "refseq_ac": "NP_776146", "gene_names_uniprotkb": "Iba57; A230051G13Rik", "gene_names_refseq": "4930543L23Rik; A230051G13Rik; C1orf69; Iba57", "protein_names_uniprotkb": "Iron-sulfur cluster assembly factor IBA57, mitochondrial; Iron-sulfur cluster assembly factor homolog", "protein_names_refseq": "IBA57, iron-sulfur cluster assembly homolog; iron-sulfur cluster assembly factor IBA57, mitochondrial isoform 1 precursor; iron-sulfur cluster assembly factor IBA57, mitochondrial; iron-sulfur cluster assembly factor homolog; putative transferase C1orf69 homolog, mitochondrial; putative transferase CAF17 homolog, mitochondrial", "tax_id": 10090, "disease": "multiple mitochondrial dysfunctions syndrome 3 (Disease Ontology:DOID:0080135); hereditary spastic paraplegia 74 (Disease Ontology:DOID:0110819)", "pathway": " (mmu:216792)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19656490;20489182;21750661;23576753;23806337", "class_list": "", "function": "Mitochondrial protein involved in the maturation of mitochondrial [4Fe-4S]-proteins in the late stage of the iron-sulfur cluster assembly pathway. Operates in cooperation with ISCA2 in the maturation of [4Fe-4S] proteins., [UniProtKB, UniProtKB]; Mouse COG0354 represents an ancient, folate-dependent protein family involved in the metabolism of Fe/S cluster containing enzymes, [RefSeq, PubMed]; Required for functional heme biosynthesis in erythroid cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9H1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CAK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60952-1", "uniprot_id": "CP250_MOUSE", "mass": 276814.0, "length": 2414, "protein_name": "Centrosome-associated protein CEP250", "gene_name": "Cep250", "organism": "Mouse", "refseq_name": "centrosome-associated protein CEP250 isoform 2", "refseq_ac": "NP_001123471", "gene_names_uniprotkb": "Cep250; Cep2; Inmp", "gene_names_refseq": "B230210E21Rik; Cep250; Cep2; Inmp", "protein_names_uniprotkb": "Centrosome-associated protein CEP250; 250 kDa centrosomal protein; C-Nap1; Centrosomal Nek2-associated protein 1; Centrosomal protein 2; Cep250; Intranuclear matrix protein", "protein_names_refseq": "250 kDa centrosomal protein; C-Nap1; centrosomal Nek2-associated protein 1; centrosome-associated protein CEP250 isoform 2; centrosome-associated protein CEP250; intranuclear matrix protein", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:16328); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "16339073;21750661;27565344;28005958;30998843;34428180;36857066;37240188;37656476;8950169", "class_list": "", "function": "Dysregulated Arginine Metabolism Is Linked to Retinal Degeneration in Cep250 Knockout Mice., [RefSeq, PubMed]; Homozygous Knockout of Cep250 Leads to a Relatively Late-Onset Retinal Degeneration and Sensorineural Hearing Loss in Mice., [RefSeq, PubMed]; Plays an important role in centrosome cohesion during interphase. Recruits CCDC102B to the proximal ends of centrioles. Maintains centrosome cohesion by forming intercentriolar linkages. Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion. May be involved in ciliogenesis., [UniProtKB, UniProtKB]; RNA-Seq Analysis Reveals an Essential Role of the cGMP-PKG-MAPK Pathways in Retinal Degeneration Caused by Cep250 Deficiency. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMB2;Q2I8G3;Q3UTR4;Q6PFF6;Q8BLC6", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0001917 photoreceptor inner segment;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0030997 regulation of centriole-centriole cohesion;GO:0000278 mitotic cell cycle;GO:0060271 cilium assembly;GO:0008104 intracellular protein localization;GO:1904781 positive regulation of protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60952-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3W1-1", "uniprot_id": "CA198_MOUSE", "mass": 35316.0, "length": 322, "protein_name": "Uncharacterized protein C1orf198 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf198 homolog", "refseq_ac": "NP_780358", "gene_names_uniprotkb": "", "gene_names_refseq": "2310022B05Rik", "protein_names_uniprotkb": "Uncharacterized protein C1orf198 homolog", "protein_names_refseq": "uncharacterized protein C1orf198 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69551)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;28528544;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCS2;Q3U2K7;Q3U3E1;Q6PDM3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C3W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCQ3-1", "uniprot_id": "NRBF2_MOUSE", "mass": 32501.0, "length": 287, "protein_name": "Nuclear receptor-binding factor 2", "gene_name": "Nrbf2", "organism": "Mouse", "refseq_name": "nuclear receptor-binding factor 2 isoform 1", "refseq_ac": "NP_001031370", "gene_names_uniprotkb": "Nrbf2", "gene_names_refseq": "NRBF-2; Nrbf2", "protein_names_uniprotkb": "Nuclear receptor-binding factor 2; NRBF-2", "protein_names_refseq": "nuclear receptor-binding factor 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:641340); (R-MMU-383280)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18619852;21750661;24849286;25428506;26495903;26740625;32350405;32543313;34530854", "class_list": "", "function": "Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (By similarity). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (PubMed:24849286). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (By similarity). May be involved in autophagosome biogenesis (By similarity). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852)., [UniProtKB, PubMed, UniProtKB, PubMed]; Involved in the induction of starvation-induced autophagy. Modulates ATG14-linked lipid kinase activity of PIK3C3 and stabilizes PI3K complex I (PI3KC3-C1) assembly (PubMed:24849286). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852)., [UniProtKB, PubMed, UniProtKB, PubMed]; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity)., [UniProtKB, UniProtKB]; NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation., [RefSeq, PubMed]; Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCG3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005667 transcription regulator complex;GO:0005776 autophagosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006914 autophagy;GO:0034976 response to endoplasmic reticulum stress;GO:0043550 regulation of lipid kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VCQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42582-1", "uniprot_id": "NKX25_MOUSE", "mass": 34163.0, "length": 318, "protein_name": "Homeobox protein Nkx-2.5", "gene_name": "Nkx2-5", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-2.5", "refseq_ac": "NP_032726", "gene_names_uniprotkb": "Nkx2-5; Csx; Nkx-2.5; Nkx2e", "gene_names_refseq": "Csx; Nkx-2.5; Nkx2-5; Nkx2.5; tinman", "protein_names_uniprotkb": "Homeobox protein Nkx-2.5; Cardiac-specific homeobox; Homeobox protein CSX; Homeobox protein NK-2 homolog E", "protein_names_refseq": "Drosophila NK2 transcription factor related, locus 5; cardiac-specific homeobox; homeobox protein CSX; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5", "tax_id": 10090, "disease": "atrioventricular block (Disease Ontology:DOID:0050820); congenital nongoitrous hypothyroidism 5 (Disease Ontology:DOID:0070125); aortic valve disease 2 (Disease Ontology:DOID:0080334); atrial heart septal defect 7 (Disease Ontology:DOID:0110112); ventricular septal defect (Disease Ontology:DOID:1657); heart septal defect (Disease Ontology:DOID:1681); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:18091)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12023302;14757752;15542826;16556915;17584735;19483677;21750661;22560297;22719862;26160456;29187734;33574455;7690144;7904557;9584153;9748262;9778505", "class_list": "", "function": "Transcription factor required for the development of the heart and the spleen (PubMed:16556915, PubMed:19483677, PubMed:22560297, PubMed:9584153). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (PubMed:9584153). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed:12023302). Binds to the core DNA motif of NPPA promoter (PubMed:19483677). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97335", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0030878 thyroid gland development;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0003166 bundle of His development;GO:0003168 Purkinje myocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P42582-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55225-1", "uniprot_id": "OTOG_MOUSE", "mass": 313620.0, "length": 2911, "protein_name": "Otogelin", "gene_name": "Otog", "organism": "Mouse", "refseq_name": "otogelin precursor", "refseq_ac": "NP_038652", "gene_names_uniprotkb": "Otog; Otgn", "gene_names_refseq": "4932420K09; Otgn; Otog; twt", "protein_names_uniprotkb": "Otogelin", "protein_names_refseq": "otogelin precursor; twister", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 18B (Disease Ontology:DOID:0110474)", "pathway": " (mmu:18419)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10655058;11506947;21750661;31776257;9405633", "class_list": "", "function": "Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes., [UniProtKB, PubMed]; Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 3, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QMN3;G3UWC8;Q3TMP0", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0005201 extracellular matrix structural constituent;GO:0046556 alpha-L-arabinofuranosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031012 extracellular matrix;GO:0016324 apical plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0007605 sensory perception of sound;GO:0008104 intracellular protein localization;GO:0060122 inner ear receptor cell stereocilium organization;GO:0046373 L-arabinose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O55225-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61644-1", "uniprot_id": "PACN1_MOUSE", "mass": 50575.0, "length": 441, "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 1", "gene_name": "Pacsin1", "organism": "Mouse", "refseq_name": "protein kinase C and casein kinase substrate in neurons protein 1", "refseq_ac": "NP_001273672", "gene_names_uniprotkb": "Pacsin1; Pacsin", "gene_names_refseq": "A830061D09Rik; H74; Pacsin1; mKIAA1379; syndapin", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons protein 1; Syndapin-1", "protein_names_refseq": "Syndapin I; protein kinase C and casein kinase substrate in neurons protein 1; syndapin-1", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:23969); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11082044;15930129;16627472;18034455;20404169;21183079;21750661;21926968;23035120;24204982;32848054;34203471;34428180;34678516;36622335;40021952;40684658;40885482;9746365", "class_list": "", "function": "Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0030100 regulation of endocytosis;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q61644-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZN4-1", "uniprot_id": "NUAK2_MOUSE", "mass": 70675.0, "length": 639, "protein_name": "NUAK family SNF1-like kinase 2", "gene_name": "Nuak2", "organism": "Mouse", "refseq_name": "NUAK family SNF1-like kinase 2 isoform A", "refseq_ac": "NP_001181954", "gene_names_uniprotkb": "Nuak2; Omphk2", "gene_names_refseq": "1200013B22Rik; Nuak2; Omphk2; Snark; mKIAA0537", "protein_names_uniprotkb": "NUAK family SNF1-like kinase 2; 2.7.11.1; Omphalocele kinase 2", "protein_names_refseq": "NUAK family SNF1-like kinase 2 isoform A; SNF1/AMP-activated protein kinase; omphalocele kinase 2", "tax_id": 10090, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (mmu:74137)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16715502;17242355;18307533;20713714;21183079;33812060;34348766;34428180;35343079", "class_list": "", "function": "Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle., [RefSeq, PubMed]; GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2., [RefSeq, PubMed]; NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network. Publication Status: Online-Only, [RefSeq, PubMed]; Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model., [RefSeq, PubMed]; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway., [UniProtKB, UniProtKB]; The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1alpha inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZW3;Q8CIC0;Q9DBV0", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0035330 regulation of hippo signaling;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BZN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGY8-1", "uniprot_id": "OGT1_MOUSE", "mass": 116952.0, "length": 1046, "protein_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "gene_name": "Ogt", "organism": "Mouse", "refseq_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2", "refseq_ac": "NP_001277464", "gene_names_uniprotkb": "Ogt", "gene_names_refseq": "1110038P24Rik; 4831420N21Rik; Ogtl; Ogt", "protein_names_uniprotkb": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; 2.4.1.255; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT", "protein_names_refseq": "O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 106 (Disease Ontology:DOID:0080240); aortic valve stenosis (Disease Ontology:DOID:1712); congenital disorder of glycosylation (Disease Ontology:DOID:5212); congestive heart failure (Disease Ontology:DOID:6000); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:108155); (R-MMU-3214847); (R-MMU-5675482); (R-MMU-5689603); (R-MMU-9772755)", "pathway_count": 5, "publication_count": 32, "publication_id_list": "12504895;14749383;16182253;19483677;21183079;22517741;22645316;23337503;23352454;23395175;23395176;23624624;24563466;25428506;25605945;28528544;28554894;29465778;31219806;32782141;32848054;33300544;34428180;34678516;34887587;35822049;36064721;36210013;36852467;39627609;40684658;40885482", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:29465778). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (By similarity). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (By similarity). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (By similarity). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (By similarity). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (By similarity). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (PubMed:23337503, PubMed:23395176). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (PubMed:23337503, PubMed:23395176). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:23337503, PubMed:23395176). O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (By similarity). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (By similarity). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Ogt mutation results in the loss of O-GlcNAc and causes T-cell apoptosis, neuronal tau hyperphosphorylation, and fibroblast growth arrest with altered expression of c-Fos, c-Jun, c-Myc, Sp1, and p27, [RefSeq, PubMed]; This transferase mediates a novel hexosamine-dependent signal transduction pathway. It is now sequenced and compared to the human and rat ogt locus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 46, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2ALY1;Q6PG10;Q8BXH6;Q91Y38", "ec_number_list": "2.4.1.255;3.4.19.12;2.3.1.48;2.3.1.-;2.7.11.1", "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0042588 zymogen granule;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 5, "hit_score": 4.2, "record_id": "Q8CGY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PG2-1", "uniprot_id": "OGFR_MOUSE", "mass": 70679.0, "length": 633, "protein_name": "Opioid growth factor receptor", "gene_name": "Ogfr", "organism": "Mouse", "refseq_name": "opioid growth factor receptor", "refseq_ac": "NP_113550", "gene_names_uniprotkb": "Ogfr", "gene_names_refseq": "2010013E17Rik; Ogfr", "protein_names_uniprotkb": "Opioid growth factor receptor; OGFr; Zeta-type opioid receptor", "protein_names_refseq": "opioid growth factor receptor; zeta-type opioid receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:72075)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11113537;21183079;22338080;24788674;25153642;28135057;28528544;36812665", "class_list": "", "function": "Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain., [RefSeq, PubMed]; Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation (By similarity)., [UniProtKB]; These data demonstrate for the first time that stable genetic amplification of OGFr downregulates homeostatic cell proliferation, as well as pathophysiological processes with respect to wound repair., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ACT6;Q99L33", "ec_number_list": "", "go_molecular_function": "GO:0140625 opioid growth factor receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99PG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D051-1", "uniprot_id": "ODPB_MOUSE", "mass": 38937.0, "length": 359, "protein_name": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "gene_name": "Pdhb", "organism": "Mouse", "refseq_name": "pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor", "refseq_ac": "NP_077183", "gene_names_uniprotkb": "Pdhb", "gene_names_refseq": "2610103L06Rik; Pdhb", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; 1.2.4.1; PDHE1-B", "protein_names_refseq": "PDHE1-B; pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor; pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "tax_id": 10090, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (mmu:68263); (R-MMU-204174); (R-MMU-5362517); (R-MMU-9837999); (R-MMU-9861559)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "18034455;23576753;26740625;31219806;31599954;33300544;34260942;35820727;36288343;36564038;37453647;37507081;39927985", "class_list": "", "function": "Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis., [RefSeq, PubMed]; Together with PDHA1 forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TL86;Q505N8;Q99LW9", "ec_number_list": "3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;3.1.2.-;3.1.2.2;2.7.11.2;2.7.11.-;3.4.21.92;1.1.1.37;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;1.1.1.42;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;3.1.3.43;1.2.4.2;1.1.1.30;6.1.1.5;2.3.1.12;2.7.1.23;3.4.21.53;5.6.2.3;2.3.1.9;2.3.1.37;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;1.3.8.1;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2G2-1", "uniprot_id": "ODO2_MOUSE", "mass": 48995.0, "length": 454, "protein_name": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "gene_name": "Dlst", "organism": "Mouse", "refseq_name": "dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "refseq_ac": "NP_084501", "gene_names_uniprotkb": "Dlst", "gene_names_refseq": "1600017E01Rik; 4632413C10Rik; 4930529O08Rik; DLTS; Dlst", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; 2.3.1.61; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K; OGDC-E2", "protein_names_refseq": "2-oxoglutarate dehydrogenase complex component E2; E2K; OGDC-E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "tax_id": 10090, "disease": "pheochromocytoma/paraganglioma syndrome 7 (Disease Ontology:DOID:0061222); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:78920); (R-MMU-6783984); (R-MMU-9853506); (R-MMU-9857492); (R-MMU-9858328)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "19660549;20173027;21183079;21750661;22645316;23576753;31219806;31361958;34428180;35822049;36288343;36854377;37507081;39927985", "class_list": "", "function": "A reduction in the DLST subunit of alpha-ketoglutarate dehydrogenase complex (KGDHC) alters the overall KGDHC activity and susceptibility to mitochondrial toxins and may contribute to the pathogenesis of neurodegenerative diseases., [RefSeq, PubMed]; Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEA0;Q4FK55;Q8CIE8", "ec_number_list": "1.2.4.-;1.8.1.4;2.3.1.168;1.2.4.2;2.3.1.-;2.3.1.200;2.3.1.61", "go_molecular_function": "GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006104 succinyl-CoA metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D2G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK24-1", "uniprot_id": "P2R3C_MOUSE", "mass": 53407.0, "length": 453, "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "gene_name": "Ppp2r3c", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "refseq_ac": "NP_067504", "gene_names_uniprotkb": "Ppp2r3c; G5pr; MNCb-1932", "gene_names_refseq": "4930511A21Rik; 5730412A08Rik; G4-1; G5pr; Ppp2r3c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; Protein phosphatase subunit G5PR", "protein_names_refseq": "phosphatase subunit gene g4-1; protein phosphatase subunit G5PR; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "tax_id": 10090, "disease": "spermatogenic failure 36 (Disease Ontology:DOID:0111921)", "pathway": " (mmu:59032)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12167160;15820313;16129705;16343422;18022237;25601926;36210013", "class_list": "", "function": "Findings suggest that G5PR is involved in both the survival of B cells and the differentiation of peritoneal B1a cells into autoantibody-producing plasma cells., [RefSeq, PubMed]; G5PR is required for the B cell receptor-mediated proliferation associated with the prevention of activation-induced cell death in mature B cells., [RefSeq, PubMed]; G5PR regulates the thymocyte unique apoptotic signal involved in JNK-mediated Caspase-3 activation but not in Bim activation., [RefSeq, PubMed]; May regulate MCM3AP phosphorylation through phosphatase recruitment (PubMed:12167160). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (By similarity). May play a role in the activation-induced cell death of B-cells (PubMed:16129705, PubMed:16343422)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RR97;Q9CSA6;Q9JJD2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0002759 regulation of antimicrobial humoral response;GO:0051900 regulation of mitochondrial depolarization;GO:0035303 regulation of dephosphorylation;GO:0032147 activation of protein kinase activity;GO:0048536 spleen development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JK24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62852-1", "uniprot_id": "RS25_MOUSE", "mass": 13742.0, "length": 125, "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "Rps25", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS25", "refseq_ac": "NP_077228", "gene_names_uniprotkb": "Rps25", "gene_names_refseq": "2810009D21Rik; Rps25", "protein_names_uniprotkb": "Small ribosomal subunit protein eS25; 40S ribosomal protein S25", "protein_names_refseq": "40S ribosomal protein S25; small ribosomal subunit protein eS25", "tax_id": 10090, "disease": "", "pathway": " (mmu:75617); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 18, "publication_id_list": "21750661;23806337;26495903;26740625;28011936;28528544;31209405;31219806;31361958;33725478;34428180;35820727;35984892;36288343;36517592;37453647;37507081;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25111", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P62852-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AQ19-1", "uniprot_id": "RTF1_MOUSE", "mass": 80797.0, "length": 715, "protein_name": "RNA polymerase-associated protein RTF1 homolog", "gene_name": "Rtf1", "organism": "Mouse", "refseq_name": "RNA polymerase-associated protein RTF1 homolog", "refseq_ac": "NP_084388", "gene_names_uniprotkb": "Rtf1", "gene_names_refseq": "2900005O08Rik; 6530416A09Rik; Gtl7; Rtf1; cbp82", "protein_names_uniprotkb": "RNA polymerase-associated protein RTF1 homolog", "protein_names_refseq": "RNA polymerase-associated protein RTF1 homolog; Rtf1, Paf1/RNA polymerase II complex component, homolog; gene trap locus 7", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:76246)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17622165;18184592;19345177;27749823;31219806;34418053;34428180", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Binds single-stranded DNA (By similarity). Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex., [UniProtKB, PubMed]; Potential role of Rtf1 Plus single stranded DNA binding during transcription elongation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q08EC5", "ec_number_list": "", "go_molecular_function": "GO:0003697 single-stranded DNA binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016055 Wnt signaling pathway;GO:0006325 chromatin organization;GO:0019827 stem cell population maintenance;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2AQ19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70622-1", "uniprot_id": "RTN2_MOUSE", "mass": 51347.0, "length": 471, "protein_name": "Reticulon-2", "gene_name": "Rtn2", "organism": "Mouse", "refseq_name": "reticulon-2 isoform C", "refseq_ac": "NP_001020535", "gene_names_uniprotkb": "Rtn2; Nspl1", "gene_names_refseq": "MMS10-P; Ms10p; NSPLI; Nspl1; Rtn2", "protein_names_uniprotkb": "Reticulon-2; NSP-like protein 1; NSP-like protein I; NSPLI; Neuroendocrine-specific protein-like 1; Neuroendocrine-specific protein-like I", "protein_names_refseq": "NSP-like protein 1; NSP-like protein I; neuroendocrine-specific protein-like 1; neuroendocrine-specific protein-like I; reticulon-2 isoform C; reticulon-2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765)", "pathway": " (mmu:20167)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10672514;15345747;19720795;21183079;25428506;30084848;39927985;9530622", "class_list": "", "function": "Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (By similarity). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (PubMed:19720795)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70620", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0005789 endoplasmic reticulum membrane;GO:0005882 intermediate filament", "go_biological_process": "GO:0015031 protein transport;GO:0046324 regulation of D-glucose import;GO:1902430 negative regulation of amyloid-beta formation;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62242-1", "uniprot_id": "RS8_MOUSE", "mass": 24205.0, "length": 208, "protein_name": "Small ribosomal subunit protein eS8", "gene_name": "Rps8", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS8", "refseq_ac": "NP_033124", "gene_names_uniprotkb": "Rps8", "gene_names_refseq": "Rps8", "protein_names_uniprotkb": "Small ribosomal subunit protein eS8; 40S ribosomal protein S8", "protein_names_refseq": "40S ribosomal protein S8; small ribosomal subunit protein eS8", "tax_id": 10090, "disease": "", "pathway": " (mmu:20116); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 15, "publication_id_list": "21183079;23806337;31219806;33300544;33725478;34428180;35820727;35984892;36288343;36517592;37453647;37507081;37828378;39627609;7694236", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09058;Q8C2G6", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P62242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62862-1", "uniprot_id": "RS30_MOUSE", "mass": 14416.0, "length": 133, "protein_name": "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein", "gene_name": "Fau", "organism": "Mouse", "refseq_name": "ubiquitin-like FUBI-ribosomal protein eS30 fusion protein", "refseq_ac": "NP_001153711", "gene_names_uniprotkb": "Fau", "gene_names_refseq": "Fau; MNSFB; MNSFbeta", "protein_names_uniprotkb": "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein; 40S ribosomal protein S30; FAU ubiquitin-like and ribosomal protein S30", "protein_names_refseq": "40S ribosomal protein S30; FAU ubiquitin-like and ribosomal protein S30; Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); MNSF-beta; monoclonal non-specific suppressor factor beta; monoclonal nonspecific suppressor factor betamonoclonal nonspecific suppressor factor beta; ubiquitin-like FUBI-ribosomal protein eS30 fusion protein; ubiquitin-like protein FUBI", "tax_id": 10090, "disease": "", "pathway": " (mmu:14109); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "21750661;23806337;27581120;30710197;36288343;36517592;39404900;7724584;7774934;8395683", "class_list": "", "function": "Component of the 40S subunit of the ribosome (PubMed:36517592). Contributes to the assembly and function of 40S ribosomal subunits (By similarity)., [UniProtKB, UniProtKB, PubMed]; Investigating the regulatory mechanism of glucose metabolism by ubiquitin-like protein MNSFbeta. Publication Status: Online-Only, [RefSeq, PubMed]; MALDI-TOF mass spectrometry fingerprinting revealed that this MNSFbeta adduct consists of an 8.5 kDa MNSFbeta and heat shock protein 60 (HSP60), a mitochondrial protein involved in protein folding., [RefSeq, PubMed]; May have pro-apoptotic activity., [UniProtKB, UniProtKB]; The association of MNSFbeta with HSPA8 may promote RANKL-induced osteoclastogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35545;Q05472;Q642K5;Q95261;Q9JJ24", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0016567 protein ubiquitination;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q149F1-1", "uniprot_id": "RUSD2_MOUSE", "mass": 61535.0, "length": 553, "protein_name": "Pseudouridylate synthase RPUSD2", "gene_name": "Rpusd2", "organism": "Mouse", "refseq_name": "pseudouridylate synthase RPUSD2", "refseq_ac": "NP_775626", "gene_names_uniprotkb": "Rpusd2", "gene_names_refseq": "4921503C21Rik; 9630001E10; Rpusd2", "protein_names_uniprotkb": "Pseudouridylate synthase RPUSD2; 5.4.99.-; 5.4.99.28; 5.4.99.42; RNA pseudouridylate synthase domain-containing protein 2", "protein_names_refseq": "RNA pseudouridylate synthase domain-containing protein 2; pseudouridylate synthase RPUSD2", "tax_id": 10090, "disease": "", "pathway": " (mmu:271842)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. In addition, it catalyzes the formation of pseudouridine mainly at positions 31 and 32 in the anticodon loop of cytosolic and mitochondrial tRNAs, and at position 34 of certain cytosolic tRNAs such as tRNA(Ile)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXL2", "ec_number_list": "5.4.99.-;5.4.99.42;5.4.99.28;5.4.99.25;5.4.99.12", "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q149F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UC65-1", "uniprot_id": "RSRP1_MOUSE", "mass": 34539.0, "length": 298, "protein_name": "Arginine/serine-rich protein 1", "gene_name": "Rsrp1", "organism": "Mouse", "refseq_name": "arginine/serine-rich protein 1", "refseq_ac": "NP_076154", "gene_names_uniprotkb": "Rsrp1; D4Wsu53e; MNCb-0169", "gene_names_refseq": "2700043I21Rik; D4Ucla2; D4Wsu53e; Rsrp1", "protein_names_uniprotkb": "Arginine/serine-rich protein 1", "protein_names_refseq": "UPF0471 protein C1orf63 homolog; arginine/serine-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27981)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;24129315;34042961;34428180", "class_list": "", "function": "Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6., [UniProtKB, UniProtKB]; Spliceosome-regulated RSRP1-dependent NF-kappaB activation promotes the glioblastoma mesenchymal phenotype., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y97;Q9CSN6;Q9D194;Q9JJF1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UC65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVR6-1", "uniprot_id": "RSPRY_MOUSE", "mass": 64322.0, "length": 576, "protein_name": "RING finger and SPRY domain-containing protein 1", "gene_name": "Rspry1", "organism": "Mouse", "refseq_name": "RING finger and SPRY domain-containing protein 1 precursor", "refseq_ac": "NP_080550", "gene_names_uniprotkb": "Rspry1; Kiaa1972", "gene_names_refseq": "4930470D19Rik; Rspry1", "protein_names_uniprotkb": "RING finger and SPRY domain-containing protein 1", "protein_names_refseq": "RING finger and SPRY domain-containing protein 1 precursor; RING finger and SPRY domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67610)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;26365341;26497270;34428180", "class_list": "", "function": "Rspry1 is expressed in skeletal muscle.Nip30 and Rspry1 common promoter region contains a conserved E-box element. Rspry1 localizes to the cytoplasm., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9F1;Q3TM35;Q3U802;Q3UKF9;Q3UYN5;Q8BMH0;Q8C039;Q9CZ54", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BVR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PI8-1", "uniprot_id": "RTN4R_MOUSE", "mass": 50987.0, "length": 473, "protein_name": "Reticulon-4 receptor", "gene_name": "Rtn4r", "organism": "Mouse", "refseq_name": "reticulon-4 receptor precursor", "refseq_ac": "NP_075358", "gene_names_uniprotkb": "Rtn4r; Ngr1; Nogor", "gene_names_refseq": "NOGOR; NgR1; NgR; Rtn4r", "protein_names_uniprotkb": "Reticulon-4 receptor; NgR1; NgR; Nogo receptor; Nogo-66 receptor; Nogo66 receptor-1", "protein_names_refseq": "nogo66 receptor-1; reticulon-4 receptor precursor", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:65079)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11201742;11891768;12089450;12097502;15504325;15647357;18411262;19052207;19367338;20093372;22325200;22406547;22923615;26335717;27339102;29095159;30899004", "class_list": "", "function": "Localization of Nogo-66 receptor at sites of axon-myelin and synaptic contact, [RefSeq, PubMed]; Myelin-associated glycoprotein(MAG) binds directly, with high affinity, to NgR; MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury, [RefSeq, PubMed]; Nogo-66 retards neurite outgrowth and induces growth cone collapse by its interaction with NgR and as yet unidentified transmembrane coreceptors. Review article, [RefSeq, PubMed]; Receptor for RTN4, OMG and MAG (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:18411262, PubMed:22923615). Functions as a receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as a receptor for chondroitin sulfate proteoglycans (PubMed:22406547). Can also bind heparin (PubMed:22406547). Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:22923615). Plays a role in postnatal brain development (PubMed:27339102). Required for normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development (PubMed:20093372). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q80WQ1", "ec_number_list": "", "go_molecular_function": "GO:0038131 neuregulin receptor activity;GO:1905573 ganglioside GM1 binding;GO:0008201 heparin binding;GO:0044877 protein-containing complex binding;GO:0035374 chondroitin sulfate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030426 growth cone", "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0007409 axonogenesis;GO:0043547 positive regulation of GTPase activity;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q99PI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D394-1", "uniprot_id": "RUFY3_MOUSE", "mass": 53007.0, "length": 469, "protein_name": "Protein RUFY3", "gene_name": "Rufy3", "organism": "Mouse", "refseq_name": "protein RUFY3 isoform 2", "refseq_ac": "NP_001276704", "gene_names_uniprotkb": "Rufy3; D5Bwg0860e; Ripx", "gene_names_refseq": "2810428M05Rik; 6330416M07Rik; D5Bwg0860e; Ripx; Rpipx; Rufy3", "protein_names_uniprotkb": "Protein RUFY3; RIPx; Rap2-interacting protein x; Singar1; Single axon-regulated protein 1", "protein_names_refseq": "protein RUFY3 isoform 2; protein RUFY3; rap2 interacting protein x; singar1; singar; single axon-regulated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52822)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16452087;16928684;21183079;21750661;24720729;29089386;31221560;33300544", "class_list": "", "function": "ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (By similarity). Plays a role in the generation of neuronal polarity formation and axon growth (PubMed:24720729). Implicated in the formation of a single axon by developing neurons (PubMed:24720729). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (By similarity). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (PubMed:24720729)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; RUFY3, a neuronally enriched protein, is essential for caspase-mediated degeneration of TRKA+ sensory axons in vitro and in vivo. Deletion of Rufy3 protects axons from degeneration, even in the presence of activated CASP3 . Dephosphorylation of RUFY3 at residue S34 appears required for axon degeneration., [RefSeq, PubMed]; Rufy3 is a physiological adapter for Rap2 and activates Tiam2/STEF in glycoprotein M6A-regulated neuronal polarity and axon growth., [RefSeq, PubMed]; We propose that Rufy3 may control mouse neuron axon development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U348;Q3UF96;Q6PE64;Q8VD10", "ec_number_list": "", "go_molecular_function": "GO:0034452 dynactin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D394-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2J0-1", "uniprot_id": "S23A1_MOUSE", "mass": 65554.0, "length": 605, "protein_name": "Solute carrier family 23 member 1", "gene_name": "Slc23a1", "organism": "Mouse", "refseq_name": "solute carrier family 23 member 1", "refseq_ac": "NP_035527", "gene_names_uniprotkb": "Slc23a1; Svct1; Yspl3", "gene_names_refseq": "D18Ucla2; SVCT1; Slc23a1; Slc23a2; YSPL3", "protein_names_uniprotkb": "Solute carrier family 23 member 1; Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1; Yolk sac permease-like molecule 3", "protein_names_refseq": "Na(+)/L-ascorbic acid transporter 1; sodium-dependent vitamin C transporter 1; solute carrier family 23 (nucleobase transporters), member 2; solute carrier family 23 member 1; yolk sac permease-like molecule 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20522); (R-MMU-196836)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17242355;21183079;21750661;25428506;30084848;34428180;36749388;36914666;39145457;9804989", "class_list": "", "function": "Sodium:L-ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each L-ascorbate (PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (By similarity) (PubMed:36749388)., [UniProtKB, UniProtKB, PubMed]; Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter. Publication Status: Online-Only, [RefSeq, PubMed]; Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNA2;Q8C3M2;Q91WR7", "ec_number_list": "", "go_molecular_function": "GO:0008520 L-ascorbate:sodium symporter activity;GO:0015229 L-ascorbic acid transmembrane transporter activity;GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015882 L-ascorbic acid transmembrane transport;GO:0070837 dehydroascorbic acid transport;GO:0030324 lung development;GO:0007420 brain development;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z2J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03347-1", "uniprot_id": "RUNX1_MOUSE", "mass": 48610.0, "length": 451, "protein_name": "Runt-related transcription factor 1", "gene_name": "Runx1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Runx1; Aml1; Cbfa2; Pebp2ab", "gene_names_refseq": "", "protein_names_uniprotkb": "Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; CBF-alpha-2; Core-binding factor subunit alpha-2; Oncogene AML-1; PEA2-alpha B; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha B subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit", "protein_names_refseq": "", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stomach cancer (Disease Ontology:DOID:10534); endometrial cancer (Disease Ontology:DOID:1380); endometriosis (Disease Ontology:DOID:289); colon signet ring adenocarcinoma (Disease Ontology:DOID:3033); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (R-MMU-549127); (R-MMU-8877330); (R-MMU-8931987); (R-MMU-8934593); (R-MMU-8936459); (R-MMU-8939236); (R-MMU-8939243); (R-MMU-8939245); (R-MMU-8939246); (R-MMU-8939247); (R-MMU-9018519)", "pathway_count": 11, "publication_count": 22, "publication_id_list": "10903914;11203699;11243869;11257229;11375505;12217689;16917507;17377532;18258917;21151104;21750661;22193545;23481257;23806337;25428506;25605945;30084848;34428180;8164679;8437866;8565077;8622955", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (PubMed:23481257). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (PubMed:21151104)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08598;Q62049;Q9ESB9;Q9ET65", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005604 basement membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0002318 myeloid progenitor cell differentiation;GO:0002573 myeloid leukocyte differentiation;GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0035162 embryonic hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52825-1", "uniprot_id": "CPT2_MOUSE", "mass": 73981.0, "length": 658, "protein_name": "Carnitine O-palmitoyltransferase 2, mitochondrial", "gene_name": "Cpt2", "organism": "Mouse", "refseq_name": "carnitine O-palmitoyltransferase 2, mitochondrial precursor", "refseq_ac": "NP_034079", "gene_names_uniprotkb": "Cpt2; Cpt-2", "gene_names_refseq": "CPTII; Cpt2", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 2, mitochondrial; 2.3.1.21; CPT II; Carnitine palmitoyltransferase II", "protein_names_refseq": "carnitine O-palmitoyltransferase 2, mitochondrial precursor; carnitine O-palmitoyltransferase 2, mitochondrial; carnitine palmitoyltransferase II", "tax_id": 10090, "disease": "muscular disease (Disease Ontology:DOID:0080000); lipid metabolism disorder (Disease Ontology:DOID:3146); brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:12896); (R-MMU-200425); (R-MMU-77305)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23576753;23806337;34428180;36288343;37453647;37507081;39927985;8307575", "class_list": "", "function": "Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFS0", "ec_number_list": "2.3.1.137;2.3.1.7;2.3.1.21;2.3.1.-;3.1.2.22", "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity;GO:0008458 carnitine O-octanoyltransferase activity;GO:0016746 acyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0001701 in utero embryonic development;GO:0006635 fatty acid beta-oxidation;GO:0006853 carnitine shuttle;GO:0009437 carnitine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P52825-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51637-1", "uniprot_id": "CAV3_MOUSE", "mass": 17358.0, "length": 151, "protein_name": "Caveolin-3", "gene_name": "Cav3", "organism": "Mouse", "refseq_name": "caveolin-3", "refseq_ac": "NP_031643", "gene_names_uniprotkb": "Cav3", "gene_names_refseq": "Cav-3; Cav3; M-cav", "protein_names_uniprotkb": "Caveolin-3; M-caveolin", "protein_names_refseq": "M-caveolin; caveolin-3", "tax_id": 10090, "disease": "rippling muscle disease 2 (Disease Ontology:DOID:0060255); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); long QT syndrome 9 (Disease Ontology:DOID:0110650); distal myopathy Tateyama type (Disease Ontology:DOID:0111191); isolated elevated serum creatine phosphokinase levels (Disease Ontology:DOID:0111338); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); myocardial infarction (Disease Ontology:DOID:5844); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:12391)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19380584;19940021;24066022;26497963;36288343;37863387;38671439;39927985;8521953", "class_list": "", "function": "CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Cav3.2 T-Type Calcium Channel Mediates Acute Itch and Contributes to Chronic Itch and Inflammation in Experimental Atopic Dermatitis., [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (PubMed:19380584). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. The encoded protein is muscle-specific and forms homooligomers in muscle cells. The protein binds and regulates phosphofructokinase M and neuronal nitric oxide synthase. It also associates with dystrophin in muscle cells. Mutations in this gene are associated with muscular dystrophy. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0071253 connexin binding;GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010831 positive regulation of myotube differentiation;GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0031579 membrane raft organization;GO:0035995 detection of muscle stretch", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P51637-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRT1-1", "uniprot_id": "CLAP2_MOUSE", "mass": 140739.0, "length": 1286, "protein_name": "CLIP-associating protein 2", "gene_name": "Clasp2", "organism": "Mouse", "refseq_name": "CLIP-associating protein 2 isoform d", "refseq_ac": "NP_001273528", "gene_names_uniprotkb": "Clasp2; Kiaa0627", "gene_names_refseq": "1500004F14Rik; 8030404L10Rik; CLASP2beta; Clasp2; mKIAA0627", "protein_names_uniprotkb": "CLIP-associating protein 2; Cytoplasmic linker-associated protein 2", "protein_names_refseq": "CLASP2alpha; CLASP2gamma; CLIP-associating protein 2 isoform d; CLIP-associating protein CLASP2; cytoplasmic linker-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76499); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;11290329;15345747;16123238;16914514;18854161;21183079;21750661;22517741;22645316;22872234;25428506;26003921;28550165;30084848;30779550;32782141;32848054;33300544;34092082;34428180;35705037;35822049;36852467;39627609;40021952;40885482", "class_list": "", "function": "CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development., [RefSeq, PubMed]; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex., [UniProtKB, UniProtKB, PubMed]; Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHE3;Q99JI3;Q9DB80", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0002162 dystroglycan binding;GO:0051010 microtubule plus-end binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0045180 basal cortex;GO:1903754 cortical microtubule plus-end;GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q8BRT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1A2-1", "uniprot_id": "CNDP2_MOUSE", "mass": 52767.0, "length": 475, "protein_name": "Cytosolic non-specific dipeptidase", "gene_name": "Cndp2", "organism": "Mouse", "refseq_name": "cytosolic non-specific dipeptidase", "refseq_ac": "NP_001276460", "gene_names_uniprotkb": "Cndp2; Cn2", "gene_names_refseq": "0610010E05Rik; Cn2; Cndp2; Dip-2; Pep-1; Pep1", "protein_names_uniprotkb": "Cytosolic non-specific dipeptidase; 3.4.-.-; 3.4.13.18; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; N-lactoyl-amino acid synthase/hydrolase; Threonyl dipeptidase", "protein_names_refseq": "CNDP dipeptidase 2 (metallopeptidase M20 family); cytosolic non-specific dipeptidase; cytosolic nonspecific dipeptidase; glutamate carboxypeptidase-like protein 1; peptidase 1; peptidase A; threonyl dipeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66054); (R-MMU-174403); (R-MMU-9753281)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15749831;18550540;21750661;22645316;25605945;31219806;31587987;34428180;35705806;35820727;37453647", "class_list": "", "function": "Cytosolic metallodipeptidase with broad substrate specificity that catalyzes the hydrolysis of amide bonds in dipeptides and pseudopeptides (PubMed:15749831, PubMed:31587987, PubMed:35705806). Substrates include L-cysteinylglycine, an intermediate metabolite of the gamma-glutamyl cycle of glutathione metabolism (By similarity). Can also hydrolyze threonyl-containing dipeptides (PubMed:31587987). Upon physiological conditions of amino acids and lactate excess can also catalyze a reverse proteolysis reaction, generating N-[(S)-lactoyl]-L-phenylalanine and possibly other N-lactoyl-amino acids which it can also hydrolyze in vitro. N-[(S)-lactoyl]-L-phenylalanine is an exercise-induced metabolite that influences food intake and systemic energy balance (PubMed:35705806). Carnosine is probably not a physiological substrate and L-homocarnosine is not a substrate for this enzyme (PubMed:15749831). Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA80;Q3TI32;Q3U7B9;Q99PV1", "ec_number_list": "3.4.11.1;3.4.11.5;3.4.13.23;3.4.13.18;3.4.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0070573 metallodipeptidase activity;GO:0008233 peptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0019184 nonribosomal peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D1A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88543-1", "uniprot_id": "CSN3_MOUSE", "mass": 47832.0, "length": 423, "protein_name": "COP9 signalosome complex subunit 3", "gene_name": "Cops3", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 3 isoform 1", "refseq_ac": "NP_036121", "gene_names_uniprotkb": "Cops3; Csn3", "gene_names_refseq": "Cops3; Csn3; Sgn3", "protein_names_uniprotkb": "COP9 signalosome complex subunit 3; JAB1-containing signalosome subunit 3; SGN3; Signalosome subunit 3", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 3; COP9 (constitutive photomorphogenic), subunit 3; COP9 complex S3; COP9 signalosome complex subunit 3 isoform 1; COP9 signalosome complex subunit 3; JAB1-containing signalosome subunit 3; signalosome subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:26572); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "12972600;21183079;21750661;31219806;33300544;34264319;35491006;36451342;37507081;9707402", "class_list": "", "function": "COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype., [RefSeq, PubMed]; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (PubMed:12972600). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity)., [UniProtKB, UniProtKB, PubMed]; The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes., [RefSeq, PubMed]; The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0001701 in utero embryonic development;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88543-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09581-1", "uniprot_id": "CSF1R_MOUSE", "mass": 109179.0, "length": 977, "protein_name": "Macrophage colony-stimulating factor 1 receptor", "gene_name": "Csf1r", "organism": "Mouse", "refseq_name": "macrophage colony-stimulating factor 1 receptor precursor", "refseq_ac": "NP_001032948", "gene_names_uniprotkb": "Csf1r; Csfmr; Fms", "gene_names_refseq": "CD115; CSF-1R; Csf1r; Csfmr; Fim-2; Fim2; Fms; M-CSF-R; M-CSFR", "protein_names_uniprotkb": "Macrophage colony-stimulating factor 1 receptor; 2.7.10.1; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms", "protein_names_refseq": "CSF-1 receptor; CSF-1-R; c-fms; macrophage colony-stimulating factor 1 receptor precursor; macrophage colony-stimulating factor 1 receptor; proto-oncogene c-Fms; proto-oncogene fms", "tax_id": 10090, "disease": "CSF1R-related brain malformation and osteopetrosis (Disease Ontology:DOID:0070343); bone development disease (Disease Ontology:DOID:0080006); colorectal carcinoma (Disease Ontology:DOID:0080199); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (Disease Ontology:DOID:0080523); stomach cancer (Disease Ontology:DOID:10534); crescentic glomerulonephritis (Disease Ontology:DOID:13139); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); infertility (Disease Ontology:DOID:5223); lung small cell carcinoma (Disease Ontology:DOID:5409); lymphopenia (Disease Ontology:DOID:614); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:12978); (R-MMU-449836)", "pathway_count": 2, "publication_count": 43, "publication_id_list": "10.1101/2023.09.13.557529;10597251;10958675;11297560;11756160;11850825;1314163;15297464;15557176;1652061;16705167;16944957;16950670;17353186;17420255;17420256;17972959;18814279;19017797;19144319;19224205;20173027;20181277;20504948;21041311;21183079;2160591;21610095;21727904;21750661;2966922;30084848;30779550;31219806;34428180;35820727;8007983;8262059;8441691;8497248;9312046;9380408;9857184", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 25, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3P1;Q9DBH9", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.3.2.27;2.7.11.13;3.6.5.2;3.1.3.48;2.7.10.4;2.7.1.40;2.7.11.23;3.1.3.86;3.1.4.11;3.1.3.56;3.1.3.36", "go_molecular_function": "GO:0005011 macrophage colony-stimulating factor receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:1990682 CSF1-CSF1R complex;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0030316 osteoclast differentiation;GO:0038145 macrophage colony-stimulating factor signaling pathway;GO:0045124 regulation of bone resorption;GO:1905523 positive regulation of macrophage migration", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "P09581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBG1-1", "uniprot_id": "CP27A_MOUSE", "mass": 60720.0, "length": 533, "protein_name": "Sterol 26-hydroxylase, mitochondrial", "gene_name": "Cyp27a1", "organism": "Mouse", "refseq_name": "sterol 26-hydroxylase, mitochondrial precursor", "refseq_ac": "NP_077226", "gene_names_uniprotkb": "Cyp27a1", "gene_names_refseq": "1300013A03Rik; Cyp27a1; Cyp27", "protein_names_uniprotkb": "Sterol 26-hydroxylase, mitochondrial; 1.14.15.15; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase", "protein_names_refseq": "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; cholesterol 27 hydroxylase; cytochrome P-450C27/25; cytochrome P450, 27a1; sterol 26-hydroxylase, mitochondrial precursor; sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; vitamin D(3) 25-hydroxylase", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); extrahepatic cholestasis (Disease Ontology:DOID:13619); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810)", "pathway": " (mmu:104086); (R-MMU-193368); (R-MMU-193775); (R-MMU-193807); (R-MMU-211976)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "23576753;28190002;30340023;34428180;36890868;37453647;37607853;37648096", "class_list": "", "function": "CYP27A1 deficiency promoted osteoclast differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation., [RefSeq, PubMed]; Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives (PubMed:30340023). Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid (By similarity). Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways (By similarity). May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (By similarity). Catalyzes the conversion of 7-ketocholesterol (7-oxocholesterol) into 7-keto,27-hydroxycholesterol, a precursor of 7-keto,27-hydroxycholesterol, an active oxysterol that activates smoothened (SMO) and the smoothened signaling pathway (PubMed:30340023). Plays a role in cholestanol metabolism in the cerebellum (PubMed:28190002). Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation (By similarity). Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium (By similarity). May play a redundant role in vitamin D biosynthesis (By similarity). Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.15.15", "go_molecular_function": "GO:0008123 cholesterol 7-alpha-monooxygenase activity;GO:0031073 cholesterol 26-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0008203 cholesterol metabolic process;GO:0006700 C21-steroid hormone biosynthetic process;GO:0006707 cholesterol catabolic process;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DBG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZS1-1", "uniprot_id": "HIBCH_MOUSE", "mass": 43038.0, "length": 385, "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "Hibch", "organism": "Mouse", "refseq_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor", "refseq_ac": "NP_666220", "gene_names_uniprotkb": "Hibch", "gene_names_refseq": "2610509I15Rik; HIBYL-COA-H; Hibch", "protein_names_uniprotkb": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase; 3.1.2.4; HIB-CoA hydrolase; HIBYL-CoA-H", "protein_names_refseq": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; HIB-CoA hydrolase", "tax_id": 10090, "disease": "3-hydroxyisobutryl-CoA hydrolase deficiency (Disease Ontology:DOID:0060949); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:227095); (R-MMU-70895)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;23576753;23806337;34428180;36288343;37507081;39927985", "class_list": "", "function": "Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.4", "go_molecular_function": "GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8QZS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60843-1", "uniprot_id": "IF4A1_MOUSE", "mass": 46154.0, "length": 406, "protein_name": "Eukaryotic initiation factor 4A-I", "gene_name": "Eif4a1", "organism": "Mouse", "refseq_name": "eukaryotic initiation factor 4A-I isoform 1", "refseq_ac": "NP_659207", "gene_names_uniprotkb": "Eif4a1; Ddx2a; Eif4a", "gene_names_refseq": "BM-010; Ddx2a; Eif4a1; Eif4", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-I; 3.6.4.13; ATP-dependent RNA helicase eIF4A-1; eIF-4A-I; eIF4A-I", "protein_names_refseq": "ATP-dependent RNA helicase eIF4A-1; eIF-4A-I; eIF4A-I; eukaryotic initiation factor 4A-I isoform 1; eukaryotic initiation factor 4A-I; initiation factor eIF-4A long form", "tax_id": 10090, "disease": "", "pathway": " (mmu:13681); (R-MMU-1169408); (R-MMU-156827); (R-MMU-429947); (R-MMU-72649); (R-MMU-72662); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "1378397;21750661;22645316;23806337;25605945;3215517;33300544;33649389;34428180;36210013;37453647;37507081;37828378;38011999;3840589;39349455;39627609", "class_list": "", "function": "ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (By similarity)., [UniProtKB, UniProtKB]; RNA helicase EIF4A1-mediated translation is essential for the GC response. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04765;Q61516", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;2.7.7.52;2.7.7.19;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.1.13.4;3.4.21.53;2.7.7.7;2.7.7.49;3.1.13.-;2.7.11.1;2.7.4.3;3.4.19.12;3.6.5.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0003743 translation initiation factor activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P60843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIL5-1", "uniprot_id": "HOOK1_MOUSE", "mass": 84439.0, "length": 728, "protein_name": "Protein Hook homolog 1", "gene_name": "Hook1", "organism": "Mouse", "refseq_name": "protein Hook homolog 1", "refseq_ac": "NP_084290", "gene_names_uniprotkb": "Hook1", "gene_names_refseq": "A930033L17Rik; Hook1; azh", "protein_names_uniprotkb": "Protein Hook homolog 1; mHK1", "protein_names_refseq": "abnormal spermatozoon head shape; hook homolog 1; mHK1; protein Hook homolog 1", "tax_id": 10090, "disease": "Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (mmu:77963)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12075009;16452087;19091768;21183079;28003339;28283191;30084848;34428180;38807192", "class_list": "", "function": "Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (By similarity). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (PubMed:12075009)., [UniProtKB, PubMed, UniProtKB]; Hook1 is a binding partner of Ccdc181., [RefSeq, PubMed]; Protein homeostasis maintained by HOOK1 levels promotes the tumorigenic and stemness properties of ovarian cancer cells through reticulum stress and autophagy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIZ2;Q8K0P1;Q8K454;Q9CTN6", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0015031 protein transport;GO:0007286 spermatid development;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BIL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5T7-1", "uniprot_id": "HORM1_MOUSE", "mass": 44933.0, "length": 392, "protein_name": "HORMA domain-containing protein 1", "gene_name": "Hormad1", "organism": "Mouse", "refseq_name": "HORMA domain-containing protein 1 isoform a", "refseq_ac": "NP_001276461", "gene_names_uniprotkb": "Hormad1; Nohma", "gene_names_refseq": "4921522K05Rik; Hormad1; Nohma", "protein_names_uniprotkb": "HORMA domain-containing protein 1; Newborn ovary HORMA protein", "protein_names_refseq": "HORMA domain containing protein; HORMA domain-containing protein 1 isoform a; HORMA domain-containing protein 1; newborn ovary HORMA protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67981)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15567723;15999985;19686734;19851446;21079677;21183079;21478856;22346761;22549958;27723721;30272023;30746471;38897409", "class_list": "", "function": "Differential phosphorylation of two serine clusters in mouse HORMAD1 during meiotic prophase I progression., [RefSeq, PubMed]; HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13., [RefSeq, PubMed]; Plays a key role in meiotic progression (PubMed:19686734, PubMed:21079677, PubMed:21478856). Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends (PubMed:19686734, PubMed:21079677). Promotes synaptonemal-complex formation independently of its role in homology search (PubMed:19686734, PubMed:21079677). Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (PubMed:21478856)., [UniProtKB, PubMed, PubMed, PubMed]; Results suggest that also mammalian cells use a HORMA domain-containing protein (HORMAD1) as part of a surveillance system that monitors chromosomal synapsis or other interactions between homologs., [RefSeq, PubMed]; The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUF3;Q9D473", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0060629 regulation of homologous chromosome segregation;GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D5T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1Y5-1", "uniprot_id": "HIC1_MOUSE", "mass": 76828.0, "length": 733, "protein_name": "Hypermethylated in cancer 1 protein", "gene_name": "Hic1", "organism": "Mouse", "refseq_name": "hypermethylated in cancer 1 protein isoform 2", "refseq_ac": "NP_001091673", "gene_names_uniprotkb": "Hic1", "gene_names_refseq": "HIC-1; Hic1", "protein_names_uniprotkb": "Hypermethylated in cancer 1 protein; Hic-1", "protein_names_refseq": "hypermethylated in cancer 1 protein isoform 2; hypermethylated in cancer 1 protein", "tax_id": 10090, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469)", "pathway": " (mmu:15248); (R-MMU-3232118)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10072440;10371200;10655551;11073960;12539045;16269335;18347096;21183079;21750661;24129315;35820727;38928090", "class_list": "", "function": "Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor (PubMed:18347096). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (By similarity). May act as a tumor suppressor (PubMed:16269335, PubMed:18347096). Involved in development of head, face, limbs and ventral body wall (PubMed:10655551). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (By similarity). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (By similarity). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (By similarity). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (By similarity). Probably represses transcription from ACKR3, FGFBP1 and EFNA1 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ARH0;Q9R1Y6;Q9R2B0", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R1Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50220-1", "uniprot_id": "NKX21_MOUSE", "mass": 38570.0, "length": 372, "protein_name": "Homeobox protein Nkx-2.1", "gene_name": "Nkx2-1", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-2.1 isoform 1", "refseq_ac": "NP_033411", "gene_names_uniprotkb": "Nkx2-1; Nkx-2.1; Titf1; Ttf1", "gene_names_refseq": "Nkx2-1; Nkx2.1; T/EBP; Titf1; Ttf-1", "protein_names_uniprotkb": "Homeobox protein Nkx-2.1; T/EBP; TTF-1; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein", "protein_names_refseq": "homeobox protein Nkx-2.1 isoform 1; homeobox protein Nkx-2.1; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; tinman", "tax_id": 10090, "disease": "choreatic disease (Disease Ontology:DOID:12859); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:21869)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22356123;22955271;7711079", "class_list": "", "function": "Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0021879 forebrain neuron differentiation;GO:0021877 forebrain neuron fate commitment;GO:0031128 developmental induction;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SZT7-1", "uniprot_id": "NKAPL_MOUSE", "mass": 44894.0, "length": 395, "protein_name": "NKAP-like protein", "gene_name": "Nkapl", "organism": "Mouse", "refseq_name": "NKAP-like protein", "refseq_ac": "NP_079995", "gene_names_uniprotkb": "Nkapl", "gene_names_refseq": "4921504I05Rik; Nkapl", "protein_names_uniprotkb": "NKAP-like protein", "protein_names_refseq": "NKAP-like protein", "tax_id": 10090, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:66707)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;22037552;25428506;25875095", "class_list": "", "function": "Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV39;Q4KKZ9;Q5EBJ1;Q6P8T3;Q9CUJ2;Q9D5Y8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5SZT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60862-1", "uniprot_id": "ORC2_MOUSE", "mass": 65893.0, "length": 576, "protein_name": "Origin recognition complex subunit 2", "gene_name": "Orc2", "organism": "Mouse", "refseq_name": "origin recognition complex subunit 2 isoform A", "refseq_ac": "NP_001258455", "gene_names_uniprotkb": "Orc2; Orc2l", "gene_names_refseq": "Orc2l; Orc2", "protein_names_uniprotkb": "Origin recognition complex subunit 2", "protein_names_refseq": "origin recognition complex subunit 2 isoform A", "tax_id": 10090, "disease": "", "pathway": " (mmu:18393); (R-MMU-176187); (R-MMU-68616); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "12614612;21750661;22674395;25428506;30084848;34428180;8808289", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity)., [UniProtKB]; Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0000785 chromatin", "go_biological_process": "GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEB4-1", "uniprot_id": "PAG15_MOUSE", "mass": 47307.0, "length": 412, "protein_name": "Lysosomal phospholipase A and acyltransferase", "gene_name": "Pla2g15", "organism": "Mouse", "refseq_name": "lysosomal phospholipase A and acyltransferase isoform 1 precursor", "refseq_ac": "NP_598553", "gene_names_uniprotkb": "Pla2g15; Lypla3", "gene_names_refseq": "ACS; LLPL; Lpla2; Lypla3; Pla2g15", "protein_names_uniprotkb": "Lysosomal phospholipase A and acyltransferase; 1-O-acylceramide synthase; 2.3.1.-; 3.1.1.32; 3.1.1.4; 3.1.1.5; ACS; LCAT-like lysophospholipase; LLPL; LPLA2; Lysophospholipase 3; Lysosomal phospholipase A2; Phospholipase A2 group XV", "protein_names_refseq": "1-O-acylceramide synthase; LCAT-like lysophospholipase; group XV phospholipase A2; lysophospholipase 3; lysosomal phospholipase A and acyltransferase isoform 1 precursor; lysosomal phospholipase A and acyltransferase; lysosomal phospholipase A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:192654); (R-MMU-1483115)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11790796;15294901;15781238;16106046;16837646;16880524;17626977;19017977;20410020;21750661;23493550;26495903;27802388;27993948;30899004;32777483", "class_list": "", "function": "Activity is anti-atherogenic and indicate that the regulation of this enzyme might be a novel drug target for the treatment of atherosclerosis, [RefSeq, PubMed]; Esterification of side-chain oxysterols by lysosomal phospholipase A2., [RefSeq, PubMed]; Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:11790796, PubMed:16106046, PubMed:16837646, PubMed:16880524, PubMed:17626977, PubMed:19017977, PubMed:20410020). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:15294901, PubMed:20410020). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines, phosphatidylethanolamines, and phosphatidylglycerols (By similarity) (PubMed:16837646, PubMed:17626977). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:16837646, PubMed:17626977). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:27993948). Required for normal phospholipid degradation in alveolar macrophages with potential implications in the clearance of pulmonary surfactant, which is mainly composed of dipalmitoylphosphatidylcholine (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine) (PubMed:15294901, PubMed:16880524, PubMed:19017977). Involved in the first step of bis(monoacylglycero)phosphate (BMP) de novo synthesis from phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (By similarity). BMP is an important player in cargo sorting and degradation, regulation of cellular cholesterol levels and intercellular communication. At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of the catalytic triad and the role of cysteine residues in lysosomal phospholipase A2, [RefSeq, PubMed]; LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveolar macrophages, [RefSeq, PubMed]; LPLA2 plays a role in the generation of CD1d complexes with thymic lipids required for the normal selection and maturation of iNKT cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCB1;Q3U303", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.32;3.1.1.34;3.1.1.3;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;3.1.1.111;3.1.1.118;2.3.1.51;3.1.4.-;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016411 acylglycerol O-acyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0046338 phosphatidylethanolamine catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006631 fatty acid metabolic process;GO:0006672 ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q8VEB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49586-1", "uniprot_id": "PCY1A_MOUSE", "mass": 41667.0, "length": 367, "protein_name": "Choline-phosphate cytidylyltransferase A", "gene_name": "Pcyt1a", "organism": "Mouse", "refseq_name": "choline-phosphate cytidylyltransferase A", "refseq_ac": "NP_001156631", "gene_names_uniprotkb": "Pcyt1a; Ctpct; Pcyt1", "gene_names_refseq": "CTalpha; Cctalpha; Ctpct; Cttalpha; Pcyt1a", "protein_names_uniprotkb": "Choline-phosphate cytidylyltransferase A; 2.7.7.15; CCT A; CCT-alpha; CT A; CTP:phosphocholine cytidylyltransferase A; Phosphorylcholine transferase A", "protein_names_refseq": "CCT A; CCT-alpha; CT A; CTP phosphocholine cytidylyl transferase; CTP:phosphocholine cytidylyltransferase A; CTP:phosphocholine cytidylyltransferase alpha; choline-phosphate cytidylyltransferase A; phosphorylcholine transferase A", "tax_id": 10090, "disease": "congenital generalized lipodystrophy (Disease Ontology:DOID:0050585); spondylometaphyseal dysplasia with cone-rod dystrophy (Disease Ontology:DOID:0112300)", "pathway": " (mmu:13026); (R-MMU-1483191)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "12842190;15798219;17242355;19131326;19139091;21183079;21343341;21750661;22645316;25153642;28135057;28528544;34428180;36288343;38858683;7918629;8307580;9148929", "class_list": "", "function": "Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina. Erratum:[BMC Biol. 2024 Jul 10;22(1):155. doi: 10.1186/s12915-024-01954-6. PMID: 38987738] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542W4", "ec_number_list": "2.7.7.15", "go_molecular_function": "GO:0004105 choline-phosphate cytidylyltransferase activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006657 CDP-choline pathway;GO:0006656 phosphatidylcholine biosynthetic process;GO:0045190 isotype switching;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P49586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70176-1", "uniprot_id": "PACA_MOUSE", "mass": 19381.0, "length": 175, "protein_name": "Pituitary adenylate cyclase-activating polypeptide", "gene_name": "Adcyap1", "organism": "Mouse", "refseq_name": "pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein", "refseq_ac": "NP_001302432", "gene_names_uniprotkb": "Adcyap1; Pacap", "gene_names_refseq": "Adcyap1; PACAP", "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide; PACAP; PRP-48", "protein_names_refseq": "pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein; pituitary adenylate cyclase-activating polypeptide", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); cystitis (Disease Ontology:DOID:1679)", "pathway": " (mmu:11516); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18055122;21750661;23913443;9573339", "class_list": "", "function": "PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (By similarity). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (PubMed:18055122). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (PubMed:23913443). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016521 pituitary adenylate cyclase activating polypeptide activity;GO:0031858 pituitary adenylate cyclase-activating polypeptide receptor binding;GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043195 terminal bouton;GO:0043204 perikaryon;GO:0043005 neuron projection;GO:0099013 neuronal dense core vesicle lumen", "go_biological_process": "GO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus;GO:0090274 positive regulation of somatostatin secretion;GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TC46-1", "uniprot_id": "PATL1_MOUSE", "mass": 86770.0, "length": 770, "protein_name": "Protein PAT1 homolog 1", "gene_name": "Patl1", "organism": "Mouse", "refseq_name": "protein PAT1 homolog 1 isoform 1", "refseq_ac": "NP_766223", "gene_names_uniprotkb": "Patl1", "gene_names_refseq": "Pat1b; Patl1", "protein_names_uniprotkb": "Protein PAT1 homolog 1; PAT1-like protein 1; Pat1b; Protein PAT1 homolog b", "protein_names_refseq": "PAT1-like protein 1; protein PAT1 homolog 1 isoform 1; protein PAT1 homolog 1; protein PAT1 homolog b", "tax_id": 10090, "disease": "", "pathway": " (mmu:225929); (R-MMU-430039)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;24129315;34428180", "class_list": "", "function": "RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD30;Q3U4Q3;Q3UD09;Q6PD49;Q8BN50;Q8C3S7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030371 translation repressor activity;GO:0002151 G-quadruplex RNA binding;GO:0008266 poly(U) RNA binding;GO:0034046 poly(G) binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0000932 P-body;GO:0016605 PML body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0017148 negative regulation of translation;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TC46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER80-1", "uniprot_id": "RTP4_MOUSE", "mass": 28392.0, "length": 249, "protein_name": "Receptor-transporting protein 4", "gene_name": "Rtp4", "organism": "Mouse", "refseq_name": "receptor-transporting protein 4", "refseq_ac": "NP_075875", "gene_names_uniprotkb": "Rtp4; Ifrg28", "gene_names_refseq": "5830458K16Rik; Ifrg28; Rtp4", "protein_names_uniprotkb": "Receptor-transporting protein 4; 28 kDa interferon-responsive protein", "protein_names_refseq": "28 kDa interferon-responsive protein; 28kD interferon alpha responsive protein; receptor-transporting protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67775)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15550249;18836069;21750661;30348895;31599954;32709745;36291680;37382452;38941768", "class_list": "", "function": "Chaperone protein that facilitates the trafficking and functional cell surface expression of some G protein-coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (PubMed:18836069). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus (By similarity). Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (PubMed:38941768). In addition, restores antiviral signaling by interacting with and sequestering influenza virus protein NS1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology., [RefSeq, PubMed]; RTP4 restricts lyssavirus rabies infection by binding to viral genomic RNA., [RefSeq, PubMed]; RTP4, a Golgi chaperone, is a regulator of the levels of heterodimers at the cell surface; association with RTP4 protects mu-delta receptors from ubiquitination and degradation, [RefSeq, PubMed]; Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine. Publication Status: Online-Only, [RefSeq, PubMed]; Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4)., [RefSeq, PubMed]; Selective MOPr-mediated increase in RTP4 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3D6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031849 olfactory receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0051607 defense response to virus;GO:0006612 protein targeting to membrane;GO:0051205 protein insertion into membrane;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ER80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDC0-1", "uniprot_id": "RUN3B_MOUSE", "mass": 45138.0, "length": 408, "protein_name": "RUN domain-containing protein 3B", "gene_name": "Rundc3b", "organism": "Mouse", "refseq_name": "RUN domain-containing protein 3B isoform 2", "refseq_ac": "NP_941022", "gene_names_uniprotkb": "Rundc3b; Gm440", "gene_names_refseq": "Gm440; Rundc3b", "protein_names_uniprotkb": "RUN domain-containing protein 3B", "protein_names_refseq": "RUN domain-containing protein 3B isoform 2; RUN domain-containing protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:242819)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;24129315", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFX5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PDC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60122-1", "uniprot_id": "RUVB1_MOUSE", "mass": 50214.0, "length": 456, "protein_name": "RuvB-like 1", "gene_name": "Ruvbl1", "organism": "Mouse", "refseq_name": "ruvB-like 1", "refseq_ac": "NP_062659", "gene_names_uniprotkb": "Ruvbl1; Tip49a; Tip49", "gene_names_refseq": "2510009G06Rik; Pontin52; Ruvbl1; Tip49a", "protein_names_uniprotkb": "RuvB-like 1; 3.6.4.12; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; Pontin 52; TIP49a", "protein_names_refseq": "49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; Pontin 52; RuvB-like protein 1; ruvB-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56505); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5696394); (R-MMU-606279)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "21750661;26740625;29187734;31219806;34428180;36438486;37507081;38609375;39627609;40021952;9843967", "class_list": "", "function": "Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). Essential for cell proliferation (By similarity). May be able to bind plasminogen at cell surface and enhance plasminogen activation (By similarity)., [UniProtKB, UniProtKB]; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding., [UniProtKB, UniProtKB]; RUVBL1 ubiquitination by DTL promotes RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35753", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.4.-.-;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;1.14.11.-;3.6.5.-;2.3.2.32;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.19.12;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0051117 ATPase binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P60122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88574-1", "uniprot_id": "SAP30_MOUSE", "mass": 23231.0, "length": 220, "protein_name": "Histone deacetylase complex subunit SAP30", "gene_name": "Sap30", "organism": "Mouse", "refseq_name": "histone deacetylase complex subunit SAP30", "refseq_ac": "NP_068560", "gene_names_uniprotkb": "Sap30", "gene_names_refseq": "30kDa; Sap30", "protein_names_uniprotkb": "Histone deacetylase complex subunit SAP30; 30 kDa Sin3-associated polypeptide; Sin3 corepressor complex subunit SAP30; Sin3-associated polypeptide p30", "protein_names_refseq": "30 kDa Sin3-associated polypeptide; Sin3-associated protein; histone deacetylase complex subunit SAP30; sin3 associated polypeptide, 30kD; sin3 corepressor complex subunit SAP30; sin3-associated polypeptide p30; sin3-associated polypeptide, 30 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:60406); (R-MMU-3214815)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11087671;19144319;20478393;21183079;28554894;9702189", "class_list": "", "function": "Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSE9;Q99JB9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000118 histone deacetylase complex;GO:0070822 Sin3-type complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14069-1", "uniprot_id": "S10A6_MOUSE", "mass": 10051.0, "length": 89, "protein_name": "Protein S100-A6", "gene_name": "S100a6", "organism": "Mouse", "refseq_name": "protein S100-A6 isoform 1", "refseq_ac": "NP_035443", "gene_names_uniprotkb": "S100a6; Cacy", "gene_names_refseq": "2A9; 5B10; CALCYCLIN; Cacy; PRA; S100a6", "protein_names_uniprotkb": "Protein S100-A6; 5B10; Calcyclin; Prolactin receptor-associated protein; S100 calcium-binding protein A6", "protein_names_refseq": "S100 calcium-binding protein A6; calcium binding protein A6 (calcyclin); prolactin receptor-associated protein; protein S100-A6 isoform 1; protein S100-A6", "tax_id": 10090, "disease": "", "pathway": " (mmu:20200)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12042313;1874170;1999197;2002257;2177633;23806337;2597136;34428180;38593315;39627609;8449996", "class_list": "", "function": "May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity)., [UniProtKB]; S100a6 knockdown promotes the differentiation of dental epithelial cells toward the epidermal lineage instead of the odontogenic lineage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P14069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50543-1", "uniprot_id": "S10AB_MOUSE", "mass": 11083.0, "length": 98, "protein_name": "Protein S100-A11", "gene_name": "S100a11", "organism": "Mouse", "refseq_name": "protein S100-A11", "refseq_ac": "NP_058020", "gene_names_uniprotkb": "S100a11; S100c", "gene_names_refseq": "EMAPI; Emap1; S100a11; S100a14; S100c; cal", "protein_names_uniprotkb": "Protein S100-A11; Calgizzarin; EMAP; Endothelial monocyte-activating polypeptide; Protein S100-C; S100 calcium-binding protein A11", "protein_names_refseq": "EMAP; S100 calcium binding protein A14; calgizzarin; calizzarin; endothelial monocyte activating polypeptide 1; endothelial monocyte-activating polypeptide; protein S100-A11; protein S100-C", "tax_id": 10090, "disease": "", "pathway": " (mmu:20195); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23806337;25428506;33075563;34311201;34428180", "class_list": "", "function": "Dicalcin suppresses in vitro trophoblast attachment in human cell lines., [RefSeq, PubMed]; Facilitates the differentiation and the cornification of keratinocytes., [UniProtKB]; S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545S1", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0014911 positive regulation of smooth muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50543-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57725-1", "uniprot_id": "SAMN1_MOUSE", "mass": 41601.0, "length": 372, "protein_name": "SAM domain-containing protein SAMSN-1", "gene_name": "Samsn1", "organism": "Mouse", "refseq_name": "SAM domain-containing protein SAMSN-1", "refseq_ac": "NP_075869", "gene_names_uniprotkb": "Samsn1", "gene_names_refseq": "4930571B16Rik; 930571B16Rik; Hacs1; SLy2; Samsn1", "protein_names_uniprotkb": "SAM domain-containing protein SAMSN-1; SAM domain, SH3 domain and nuclear localization signals protein 1; SH3 protein expressed in lymphocytes 2; SH3-lymphocyte protein 2; SLy2", "protein_names_refseq": "SAM domain, SH3 domain and nuclear localisation signals, 1; SAM domain, SH3 domain and nuclear localization signals protein 1; SAM domain-containing protein SAMSN-1; SH3 protein expressed in lymphocytes 2; SH3-lymphocyte protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67742)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15381729;17242355;17947660;19144319;19923443;20478393;21183079;21296879;25117979;25330943;25605945;30759861;30779550;34428180;36210013", "class_list": "", "function": "Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells., [RefSeq, PubMed]; This is the first study to identify deletion of a key gene in the C57BL/KaLwRij mice that also displays reduced gene expression in patients with MM and is therefore likely to play an integral role in MM disease development., [RefSeq, PubMed]; This study suggests that Hacs1 is an immunoinhibitory adaptor that might be a useful target for immune suppression therapy., [RefSeq, PubMed]; We also carried out transgene rescue by adding Sly1/2 transgenes to mice with NPYq deletions. We demonstrated that SLY1/2 expression in mutant mice decreased proportionally to deletion size, with ~12% of SLY1/2 retained in shSLY sh367 testes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2LE09;Q5RKU0;Q6P210;Q8C6S2", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001726 ruffle", "go_biological_process": "GO:1902531 regulation of intracellular signal transduction;GO:0050869 negative regulation of B cell activation;GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation;GO:0002820 negative regulation of adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P57725-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VDN7-1", "uniprot_id": "RUND1_MOUSE", "mass": 67865.0, "length": 615, "protein_name": "RUN domain-containing protein 1", "gene_name": "Rundc1", "organism": "Mouse", "refseq_name": "RUN domain-containing protein 1", "refseq_ac": "NP_766154", "gene_names_uniprotkb": "Rundc1", "gene_names_refseq": "D930024B17; Rundc1", "protein_names_uniprotkb": "RUN domain-containing protein 1", "protein_names_refseq": "RUN domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "May play a role as p53/TP53 inhibitor and thus may have oncogenic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDN6;Q3U072;Q8C3C0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VDN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64131-1", "uniprot_id": "RUNX3_MOUSE", "mass": 43518.0, "length": 409, "protein_name": "Runt-related transcription factor 3", "gene_name": "Runx3", "organism": "Mouse", "refseq_name": "runt-related transcription factor 3 isoform 2", "refseq_ac": "NP_001355979", "gene_names_uniprotkb": "Runx3; Aml2; Cbfa3; Pebp2a3", "gene_names_refseq": "AML2; Cbfa3; Pebp2a3; Runx3; Rx3", "protein_names_uniprotkb": "Runt-related transcription factor 3; Acute myeloid leukemia 2 protein; CBF-alpha-3; Core-binding factor subunit alpha-3; Oncogene AML-2; PEA2-alpha C; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit", "protein_names_refseq": "CBF-alpha-3; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; acute myeloid leukemia 2 protein; core binding factor alpha 3; core-binding factor subunit alpha-3; oncogene AML-2; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; runt-related transcription factor 3 isoform 2; transcription factor AML2/CBFA3", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); developmental disorder of mental health (Disease Ontology:DOID:0060037); idiopathic scoliosis (Disease Ontology:DOID:0060250); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:12399); (R-MMU-8941855); (R-MMU-8941856); (R-MMU-8941858); (R-MMU-8951430); (R-MMU-8951671); (R-MMU-8951936)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "11733147;16651517;18258917;21151104;23481257;34428180;39919739;7607689;7607690", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (By similarity). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (PubMed:23481257). Necessary for the development and survival of sensory neurons expressing parvalbumin (PubMed:39919739)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2FDG4;Q99P92;Q9R199", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0071559 response to transforming growth factor beta;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLI8-1", "uniprot_id": "SART3_MOUSE", "mass": 109619.0, "length": 962, "protein_name": "Spliceosome associated factor 3, U4/U6 recycling protein", "gene_name": "Sart3", "organism": "Mouse", "refseq_name": "spliceosome associated factor 3, U4/U6 recycling protein isoform 2", "refseq_ac": "NP_058622", "gene_names_uniprotkb": "Sart3; Kiaa0156", "gene_names_refseq": "Sart3; mKIAA0156", "protein_names_uniprotkb": "Spliceosome associated factor 3, U4/U6 recycling protein; SART-3; Squamous cell carcinoma antigen recognized by T-cells 3; Tumor-rejection antigen SART3; mSART-3", "protein_names_refseq": "SART-3; mSART-3; spliceosome associated factor 3, U4/U6 recycling protein isoform 2; spliceosome associated factor 3, U4/U6 recycling protein; tumor-rejection antigen SART3", "tax_id": 10090, "disease": "spermatogenic failure (Disease Ontology:DOID:0111910)", "pathway": " (mmu:53890)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10463607;10761712;12578909;21447833;21913724;31219806;34428180;36210013;39627609", "class_list": "", "function": "U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (PubMed:21447833)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQI2;Q8BPK9;Q8C3B7;Q8CFU9", "ec_number_list": "", "go_molecular_function": "GO:0030624 U6atac snRNA binding;GO:0030621 U4 snRNA binding;GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0061574 ASAP complex", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000902 cell morphogenesis;GO:0006334 nucleosome assembly;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JLI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG87-1", "uniprot_id": "TET3_MOUSE", "mass": 194792.0, "length": 1803, "protein_name": "Methylcytosine dioxygenase TET3", "gene_name": "Tet3", "organism": "Mouse", "refseq_name": "methylcytosine dioxygenase TET3 isoform 1", "refseq_ac": "NP_001334242", "gene_names_uniprotkb": "Tet3; Cxxc10", "gene_names_refseq": "B430006D22Rik; D230004J03Rik; Tet3", "protein_names_uniprotkb": "Methylcytosine dioxygenase TET3; 1.14.11.80", "protein_names_refseq": "methylcytosine dioxygenase TET3 isoform 1; probable methylcytosine dioxygenase TET3; tet oncogene family member 3", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:194388)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "20639862;21321204;21407207;21750661;21778364;21892189;22645316;22722204;23151479;23217707;23690950;24129315;24357321;25557551;25568311;26774490;28930672;31219806;34428180;35820727;36210013;36852467;37903183;40997131", "class_list": "", "function": "All three mouse Tet proteins (Tet1, Tet2 and Tet3) can also catalyse conversion of 5-methylcytosine of DNA to 5-hydroxymethylcytosine, [RefSeq, PubMed]; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "K9JH93;L0HN04;Q4VAD3;Q8C8N8;Q8CI60", "ec_number_list": "2.1.1.319;1.14.11.80", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008327 methyl-CpG binding;GO:0070579 DNA 5-methylcytosine dioxygenase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001939 female pronucleus;GO:0005694 chromosome", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006493 protein O-linked glycosylation;GO:0044727 epigenetic programing of male pronucleus;GO:0010557 positive regulation of macromolecule biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8BG87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UND0-1", "uniprot_id": "SKAP2_MOUSE", "mass": 40712.0, "length": 358, "protein_name": "Src kinase-associated phosphoprotein 2", "gene_name": "Skap2", "organism": "Mouse", "refseq_name": "src kinase-associated phosphoprotein 2", "refseq_ac": "NP_061243", "gene_names_uniprotkb": "Skap2; Prap; Ra70; Saps; Scap2; Skap55r", "gene_names_refseq": "2610021A10Rik; RA70; SKAP-HOM; Saps; Scap2; Skap2; mSKAP55R", "protein_names_uniprotkb": "Src kinase-associated phosphoprotein 2; Pyk2/RAFTK-associated protein; SKAP-HOM; SKAP55 homolog; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; Src-associated adapter protein with PH and SH3 domains", "protein_names_refseq": "SKAP55 homologue; Src-associated adaptor protein; pyk2/RAFTK-associated protein; src kinase-associated phosphoprotein 2; src kinase-associated phosphoprotein 55-related protein; src-associated adapter protein with PH and SH3 domains", "tax_id": 10090, "disease": "", "pathway": " (mmu:54353); (R-MMU-391160)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10469599;11063873;11207596;12893833;15592455;15894167;16135797;17003372;17947660;19026786;21750661;25428506;25605945;28135057;30779550;32392230;34428180;35034964;35820727;9755858", "class_list": "", "function": "May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; SKAP2 suppresses inflammation-mediated tumorigenesis by regulating SHP-1 and SHP-2., [RefSeq, PubMed]; These findings reveal that YopH prevents activation of both SKAP2-dependent and -independent neutrophilic defenses, uncouple integrin- and GPCR-dependent ROS production from FcgammaR responses based on their SKAP2 dependency, and show that SKAP2 is not required for degranulation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK74;Q9Z2K4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042113 B cell activation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q3UND0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61202-1", "uniprot_id": "CSN2_MOUSE", "mass": 51597.0, "length": 443, "protein_name": "COP9 signalosome complex subunit 2", "gene_name": "Cops2", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 2 isoform c", "refseq_ac": "NP_001272441", "gene_names_uniprotkb": "Cops2; Csn2; Trip15", "gene_names_refseq": "Cops2; Csn2; Sgn2; TRIP-15; Trip15", "protein_names_uniprotkb": "COP9 signalosome complex subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; SGN2; Signalosome subunit 2; TR-interacting protein 15; TRIP-15; Thyroid receptor-interacting protein 15", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 2; COP9 signalosome complex subunit 2 isoform c; COP9 signalosome complex subunit 2; JAB1-containing signalosome subunit 2; TR-interacting protein 15; alien homolog; alien-like; thyroid receptor-interacting protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:12848); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664); (R-MMU-9013422)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10087198;11967155;12522100;12972599;21750661;22645316;27226076;31219806;32408015;33300544;34203471;34428180;36210013;9707402", "class_list": "", "function": "Cops2, but not the whole COP9 signalosome, is essential for pluripotency maintenance in mouse embryonic stem cells. Down-regulation of Cops2 reduces expression of pluripotency genes, slows proliferation rate, arrests G2/M cell cycle, and compromises ESC embryoid differentiation. Cops2 binds to Nanog protein and prevents degradation. Cops2 functions as transcriptional corepressor to facilitate pluripotency maintenance. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1., [UniProtKB, PubMed, PubMed, PubMed]; Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88950;Q15647;Q3V1W6;Q8R5B0;Q9CWU1;Q9R249;Q9UNQ5", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0008283 cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P61202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YA8-1", "uniprot_id": "CRUM2_MOUSE", "mass": 134760.0, "length": 1282, "protein_name": "Protein crumbs homolog 2", "gene_name": "Crb2", "organism": "Mouse", "refseq_name": "protein crumbs homolog 2 isoform 1 precursor", "refseq_ac": "NP_001157038", "gene_names_uniprotkb": "Crb2", "gene_names_refseq": "5930402A21; Crb2", "protein_names_uniprotkb": "Protein crumbs homolog 2; Crumbs-like protein 2; crumbs2", "protein_names_refseq": "crumbs-like protein 2; crumbs2; protein crumbs homolog 2 isoform 1 precursor; protein crumbs homolog 2", "tax_id": 10090, "disease": "Leber congenital amaurosis 8 (Disease Ontology:DOID:0110079); retinitis pigmentosa 12 (Disease Ontology:DOID:0110358); focal segmental glomerulosclerosis 9 (Disease Ontology:DOID:0111134); ventriculomegaly - cystic kidney disease (Disease Ontology:DOID:0111625); retinitis pigmentosa (Disease Ontology:DOID:10584); Leber congenital amaurosis (Disease Ontology:DOID:14791); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:241324)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15851977;17920587;21750661;22072575;23001562;26496195;26802325;27870829;35985815", "class_list": "", "function": "A Novel Mouse Model of Idiopathic Nephrotic Syndrome Induced by Immunization with the Podocyte Protein Crb2., [RefSeq, PubMed]; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (PubMed:26496195, PubMed:27870829). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (PubMed:27870829). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (PubMed:27870829). Also required for maintenance of the apical polarity complex during development of the cortex., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "A2ALU1;Q6P6N1", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding;GO:0019828 aspartic-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0055111 ingression involved in gastrulation with mouth forming second;GO:0072359 circulatory system development;GO:0045494 photoreceptor cell maintenance;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80YA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2V7-1", "uniprot_id": "CORO7_MOUSE", "mass": 100812.0, "length": 922, "protein_name": "Coronin-7", "gene_name": "Coro7", "organism": "Mouse", "refseq_name": "coronin-7", "refseq_ac": "NP_084481", "gene_names_uniprotkb": "Coro7", "gene_names_refseq": "0610011B16Rik; Coro7", "protein_names_uniprotkb": "Coronin-7; 70 kDa WD repeat tumor rejection antigen homolog; Crn7", "protein_names_refseq": "70 kDa WD repeat tumor rejection antigen homolog; coronin-7; crn7", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:78885)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15327992;21183079;21750661;25887538;26495903;26740625;27143109;31219806;39627609", "class_list": "", "function": "F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Profiling of Coro7 mRNA expression revealed it is highly expressed in appetite and energy balance regulating regions of the brain; food deprivation downregulates hypothalamic Coro7 mRNA; conclude that coronin 7 is involved in the regulation of energy homeostasis and this role stems, to some degree, from the effect on feeding for calories and Publication Status: Online-Only, [RefSeq, PubMed]; We conclude that CRN7 spatiotemporally influences F-actin organization and Golgi integrity in a Cdc42- and N-WASP-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDJ4;Q6P8Y8;Q8C9V7", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0016477 cell migration;GO:0030041 actin filament polymerization;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D2V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18760-1", "uniprot_id": "COF1_MOUSE", "mass": 18560.0, "length": 166, "protein_name": "Cofilin-1", "gene_name": "Cfl1", "organism": "Mouse", "refseq_name": "cofilin-1", "refseq_ac": "NP_031713", "gene_names_uniprotkb": "Cfl1", "gene_names_refseq": "Cfl1; Cof", "protein_names_uniprotkb": "Cofilin-1; Cofilin, non-muscle isoform", "protein_names_refseq": "cofilin-1; n-cofilin", "tax_id": 10090, "disease": "West syndrome (Disease Ontology:DOID:0050562); vitamin B12 deficiency (Disease Ontology:DOID:0050731); autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); brain compression (Disease Ontology:DOID:11457); nephrotic syndrome (Disease Ontology:DOID:1184); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); gallbladder carcinoma (Disease Ontology:DOID:4948); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:12631)", "pathway_count": 1, "publication_count": 43, "publication_id_list": "11809832;15592455;15649475;16452087;17947660;19129405;19131326;20173027;21183079;21540332;21750661;22645316;2349104;25107909;25153642;25208553;25428506;25605945;26740625;27723745;28315936;28528544;30115939;30550596;30779550;31219806;31375980;32782141;33300544;33392910;33649389;33725478;34428180;35820727;35984892;36210013;36288343;36852467;37453647;39627609;39927985;40885482;8294869", "class_list": "", "function": "Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11809832). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:25208553). Required for the centralization of the mitotic spindle and symmetric division of zygotes (PubMed:25208553). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (PubMed:15649475)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0051015 actin filament binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0090732 cofilin-actin rod;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001842 neural fold formation;GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0030835 negative regulation of actin filament depolymerization;GO:0051293 establishment of spindle localization;GO:2000814 positive regulation of barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P18760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60991-1", "uniprot_id": "CP7B1_MOUSE", "mass": 58470.0, "length": 507, "protein_name": "Cytochrome P450 7B1", "gene_name": "Cyp7b1", "organism": "Mouse", "refseq_name": "cytochrome P450 7B1 isoform 1", "refseq_ac": "NP_031851", "gene_names_uniprotkb": "Cyp7b1", "gene_names_refseq": "Cyp7b1; D3Ertd552e; hct-1", "protein_names_uniprotkb": "Cytochrome P450 7B1; 1.14.14.26; 1.14.14.29; 24-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; HCT-1; Hippocampal transcript 1 protein; Oxysterol 7-alpha-hydroxylase", "protein_names_refseq": "24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; cytochrome P450 7B1 isoform 1; cytochrome P450 7B1; cytochrome P450, 7b1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase", "tax_id": 10090, "disease": "hereditary spastic paraplegia 5A (Disease Ontology:DOID:0110810); congenital bile acid synthesis defect 3 (Disease Ontology:DOID:0111070)", "pathway": " (mmu:13123); (R-MMU-192105); (R-MMU-193368); (R-MMU-193807); (R-MMU-211976)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10748047;11067870;22999953;34428180;36210013;37648096;38382532;8530364;9144166;9295351", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10748047, PubMed:11067870, PubMed:9144166, PubMed:9295351). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:10748047, PubMed:11067870, PubMed:9144166, PubMed:9295351). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:10748047, PubMed:11067870, PubMed:9144166, PubMed:9295351). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (PubMed:22999953). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:9144166). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; CYP7B1-mediated 25-hydroxycholesterol degradation maintains quiescence-activation balance and improves therapeutic potential of mesenchymal stem cells., [RefSeq, PubMed]; Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZ39", "ec_number_list": "2.3.1.48;1.14.14.26;1.14.14.29;1.14.14.23", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008395 steroid hydroxylase activity;GO:0033782 24S-hydroxycholesterol 7-alpha-hydroxylase activity;GO:0033783 25-hydroxycholesterol 7-alpha-hydroxylase activity", "go_cellular_component": "GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0007613 memory;GO:0008203 cholesterol metabolic process;GO:0042632 cholesterol homeostasis;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60991-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29352-1", "uniprot_id": "PTN22_MOUSE", "mass": 89714.0, "length": 802, "protein_name": "Tyrosine-protein phosphatase non-receptor type 22", "gene_name": "Ptpn22", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 22 isoform 1", "refseq_ac": "NP_033005", "gene_names_uniprotkb": "Ptpn22; Ptpn8", "gene_names_refseq": "70zpep; PEP; Ptpn22; Ptpn8", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 22; 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; PEP; PEST-domain phosphatase", "protein_names_refseq": "PEST domain-enriched tyrosine phosphatase; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; protein tyrosine phosphatase, non-receptor type 8; tyrosine-protein phosphatase non-receptor type 22 isoform 1; tyrosine-protein phosphatase non-receptor type 22", "tax_id": 10090, "disease": "Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Addison's disease (Disease Ontology:DOID:13774); hypothyroidism (Disease Ontology:DOID:1459); urticaria (Disease Ontology:DOID:1555); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); coronary artery disease (Disease Ontology:DOID:3393); systemic scleroderma (Disease Ontology:DOID:418); myasthenia gravis (Disease Ontology:DOID:437); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Meniere's disease (Disease Ontology:DOID:9849); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:19260); (R-MMU-202427); (R-MMU-202430)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11685249;1373816;15786712;16938887;19144319;21183079;21750661;23871208;23991106;25428506;27043286;30084848;30779550;35820727;39083881;39227386;8890164", "class_list": "", "function": "Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (By similarity). Associates with and probably dephosphorylates CBL (By similarity). Dephosphorylates LCK at its activating 'Tyr-394' residue (By similarity). Dephosphorylates ZAP70 at its activating 'Tyr-492' residue (By similarity). Dephosphorylates the immune system activator SKAP2 (By similarity). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (PubMed:23871208). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (PubMed:16938887)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression. Publication Status: Online-Only, [RefSeq, PubMed]; PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMP9", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.10.2;2.7.10.4;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0016791 phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0042307 positive regulation of protein import into nucleus;GO:0032727 positive regulation of interferon-alpha production;GO:0006629 lipid metabolic process;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P29352-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26516-1", "uniprot_id": "PSMD7_MOUSE", "mass": 36540.0, "length": 321, "protein_name": "26S proteasome non-ATPase regulatory subunit 7", "gene_name": "Psmd7", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 7", "refseq_ac": "NP_034947", "gene_names_uniprotkb": "Psmd7; Mov-34; Mov34", "gene_names_refseq": "Mov-34; Mov34; Psmd7", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 7; 26S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Mov34 protein; Proteasome subunit p40", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 7; 26S proteasome regulatory subunit S12; 26S proteasome regulatory subunit rpn8; proteasome subunit p40", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); neurodegenerative disease (Disease Ontology:DOID:1289); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:17463); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 9, "publication_id_list": "1837787;2209467;23576753;26495903;30084848;31219806;34428180;34512150;37507081", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB]; Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW61;Q8C0I8", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0008021 synaptic vesicle;GO:0000502 proteasome complex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P26516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BU03-1", "uniprot_id": "PWP2_MOUSE", "mass": 102910.0, "length": 919, "protein_name": "Periodic tryptophan protein 2 homolog", "gene_name": "Pwp2", "organism": "Mouse", "refseq_name": "periodic tryptophan protein 2 homolog", "refseq_ac": "NP_083822", "gene_names_uniprotkb": "Pwp2; Pwp2h", "gene_names_refseq": "6530411D08Rik; Pwp2h; Pwp2; wdp103", "protein_names_uniprotkb": "Periodic tryptophan protein 2 homolog", "protein_names_refseq": "WD-repeat protein p103; periodic tryptophan protein 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:110816); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17242355;20173027;21183079;23806337;25428507;31219806;34428180;34887587;37828378", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTR0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BU03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4E6-1", "uniprot_id": "PURG_MOUSE", "mass": 39938.0, "length": 350, "protein_name": "Purine-rich element-binding protein gamma", "gene_name": "Purg", "organism": "Mouse", "refseq_name": "purine-rich element-binding protein gamma isoform b", "refseq_ac": "NP_001091703", "gene_names_uniprotkb": "Purg", "gene_names_refseq": "4930486B15Rik; Purg", "protein_names_uniprotkb": "Purine-rich element-binding protein gamma", "protein_names_refseq": "purine-rich element-binding protein gamma isoform b; purine-rich element-binding protein gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:75029)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12034829;21183079;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14B11;Q8R4E7", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0032422 purine-rich negative regulatory element binding", "go_cellular_component": "GO:0005634 nucleus;GO:0045202 synapse", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R4E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKV1-1", "uniprot_id": "ADRM1_MOUSE", "mass": 42060.0, "length": 407, "protein_name": "Proteasomal ubiquitin receptor ADRM1", "gene_name": "Adrm1", "organism": "Mouse", "refseq_name": "proteasomal ubiquitin receptor ADRM1", "refseq_ac": "NP_062796", "gene_names_uniprotkb": "Adrm1; Gp110", "gene_names_refseq": "1110063P18Rik; 2510006J17Rik; ARM-1; Adrm1; Arm1; Gp110; Rpn13", "protein_names_uniprotkb": "Proteasomal ubiquitin receptor ADRM1; 110 kDa cell membrane glycoprotein; ARM-1; Adhesion-regulating molecule 1; Gp110; Rpn13 homolog", "protein_names_refseq": "110 kDa cell membrane glycoprotein; adhesion-regulating molecule 1; glycoprotein 110; proteasomal ubiquitin receptor ADRM1; rpn13 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:56436); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 56, "publication_count": 27, "publication_id_list": "10919708;15819879;16815440;17139257;18497817;18497827;22645316;25605945;26495903;27815841;28011936;29209146;30016717;30059200;30414351;31219806;31599954;32782141;32848054;33725478;34203471;34428180;35820727;35822049;36852467;40021952;40885482", "class_list": "", "function": "ADRM1-dependent ubiquitin proteasome system (UPS) may be a general mechanism to guard cells from mutant Htt toxicity, [RefSeq, PubMed]; ARM-1 is a cytosolic protein associated with the plasma membrane. However, no cell surface expression of the protein was observed. These results suggest an indirect role of ARM-1 in adhesion rather than a direct role as an adhesion molecule itself., [RefSeq, PubMed]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:18497827). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:18497827). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:18497827). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497827). Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (By similarity). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (By similarity)., [UniProtKB, PubMed, UniProtKB]; Here, the authors show that Shigella flexneri invasion plasmid antigen H (IpaH) 4.5, a member of the E3 ubiquitin ligase effector family, targets the proteasome regulatory particle non-ATPase 13 (RPN13) and induces its degradation via the ubiquitin-proteasome system (UPS)., [RefSeq, PubMed]; Identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome, [RefSeq, PubMed]; Studies suggest that HAP40-mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKZ8;Q8BPH8;Q922A7", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0061133 endopeptidase activator activity;GO:0070628 proteasome binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0060399 positive regulation of growth hormone receptor signaling pathway;GO:0060612 adipose tissue development;GO:0007286 spermatid development;GO:0048538 thymus development", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q9JKV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63040-1", "uniprot_id": "CPLX1_MOUSE", "mass": 15122.0, "length": 134, "protein_name": "Complexin-1", "gene_name": "Cplx1", "organism": "Mouse", "refseq_name": "complexin-1", "refseq_ac": "NP_031782", "gene_names_uniprotkb": "Cplx1", "gene_names_refseq": "921-S; Cplx1", "protein_names_uniprotkb": "Complexin-1; 921-S; CPX I; Complexin I; Synaphin-2", "protein_names_refseq": "CPX I; complexin I; complexin-1; synaphin-2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 63 (Disease Ontology:DOID:0080426); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:12889); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642); (R-MMU-888590)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "15121237;15126625;15911881;16000319;21750661;23345244;38834904;7635198", "class_list": "", "function": "Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway., [RefSeq, PubMed]; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:23345244). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:23345244). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior (PubMed:15126625, PubMed:16000319)., [UniProtKB, PubMed, PubMed, PubMed]; We studied the mRNA distribution of CPLXI and CPLXII in mouse brain. We show that while CPLXs are expressed in distinct cell populations they do not segregate with particular neurotransmitters or different classes of transmitter action, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09057;O09142;Q3UYB3;Q64276;Q91WJ3", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0000149 SNARE binding;GO:0017075 syntaxin-1 binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0030073 insulin secretion;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis;GO:0099145 regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P63040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTV2-1", "uniprot_id": "CPSF7_MOUSE", "mass": 52011.0, "length": 471, "protein_name": "Cleavage and polyadenylation specificity factor subunit 7", "gene_name": "Cpsf7", "organism": "Mouse", "refseq_name": "cleavage and polyadenylation specificity factor subunit 7 isoform 2", "refseq_ac": "NP_001157744", "gene_names_uniprotkb": "Cpsf7", "gene_names_refseq": "5730453I16Rik; C330017N18Rik; Cpsf7", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 7", "protein_names_refseq": "cleavage and polyadenylation specificity factor subunit 7 isoform 2; cleavage and polyadenylation specificity factor subunit 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:269061); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9013422); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19131326;21183079;21750661;25428506;30084848;34428180;40997131", "class_list": "", "function": "Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNF1;Q8BKE7;Q8CFS8", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0051262 protein tetramerization;GO:0051290 protein heterotetramerization;GO:0031124 mRNA 3'-end processing;GO:0110104 mRNA alternative polyadenylation;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BTV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C196-1", "uniprot_id": "CPSM_MOUSE", "mass": 164618.0, "length": 1500, "protein_name": "Carbamoyl-phosphate synthase [ammonia], mitochondrial", "gene_name": "Cps1", "organism": "Mouse", "refseq_name": "carbamoyl-phosphate synthase [ammonia], mitochondrial precursor", "refseq_ac": "NP_001074278", "gene_names_uniprotkb": "Cps1", "gene_names_refseq": "4732433M03Rik; CPS; Cps1; D1Ucla3", "protein_names_uniprotkb": "Carbamoyl-phosphate synthase [ammonia], mitochondrial; 6.3.4.16; CPSase I; Carbamoyl-phosphate synthetase I", "protein_names_refseq": "CPSase I; carbamoyl-phosphate synthase [ammonia], mitochondrial precursor; carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase I; carbamoylphosphate synthetase I", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); hypertension (Disease Ontology:DOID:10763); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); vascular disease (Disease Ontology:DOID:178); hepatocellular carcinoma (Disease Ontology:DOID:684); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:227231); (R-MMU-70635)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19410549;20097174;21183079;22076378;23576753;23806337;24703693;25428506;28011936;29562282;30084848;34428180;34799567;35285892;36064721;37453647;37489865", "class_list": "", "function": "Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1., [RefSeq, PubMed]; Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1., [RefSeq, PubMed]; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell., [UniProtKB, PubMed]; SIRT5 deacetylates CPS1 and upregulates its activity, [RefSeq, PubMed]; This gene encodes a protein localized to the inner mitochondrial matrix. The encoded protein plays a role in the detoxification of ammonia by catalyzing the first step in the urea cycle in which carbomyl-phosphate is synthesized from ammonia and bicarbonate. Carbamoyl-phosphate is subsequently converted to urea that is excreted by the kidneys. Deficiency of the encoded enzyme leads to an accumulation of ammonia in the blood. High levels of ammonia are toxic to the central nervous system and result in neurological disorders. [provided by RefSeq, Oct 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A0JNU4;Q6NX75", "ec_number_list": "6.3.4.16;2.1.3.2;3.5.2.3;6.3.5.5;3.5.1.2;2.3.1.-", "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004175 endopeptidase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0055081 monoatomic anion homeostasis;GO:0070409 carbamoyl phosphate biosynthetic process;GO:0071400 cellular response to oleic acid;GO:0097305 response to alcohol", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q8C196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CF98-1", "uniprot_id": "COL10_MOUSE", "mass": 30524.0, "length": 277, "protein_name": "Collectin-10", "gene_name": "Colec10", "organism": "Mouse", "refseq_name": "collectin-10 precursor", "refseq_ac": "NP_775598", "gene_names_uniprotkb": "Colec10; Cll1", "gene_names_refseq": "CL-L1; Colec10", "protein_names_uniprotkb": "Collectin-10; CL-L1; Collectin liver protein 1", "protein_names_refseq": "collectin liver 1; collectin liver protein 1; collectin-10 precursor; collectin-10; collectin-L1", "tax_id": 10090, "disease": "3MC syndrome 3 (Disease Ontology:DOID:0060577)", "pathway": " (mmu:239447); (R-MMU-166662)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12450124;23814060;28301481;38036508", "class_list": "glycogene", "function": "During acute-phase responses, the CL-L1 levels display only minor variations. In serum, CL-L1 was found in complexes with mannan-binding lectin-associated serine proteases, suggesting a role in the lectin pathway of complement activation., [RefSeq, PubMed]; Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration., [UniProtKB, UniProtKB]; Mouse collectin liver 1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q, [RefSeq, PubMed]; The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1C5", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0009792 embryo development ending in birth or egg hatching;GO:0006508 proteolysis;GO:0006952 defense response;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CF98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKJ9-1", "uniprot_id": "CP39A_MOUSE", "mass": 53575.0, "length": 470, "protein_name": "24-hydroxycholesterol 7-alpha-hydroxylase", "gene_name": "Cyp39a1", "organism": "Mouse", "refseq_name": "24-hydroxycholesterol 7-alpha-hydroxylase isoform 1", "refseq_ac": "NP_061375", "gene_names_uniprotkb": "Cyp39a1", "gene_names_refseq": "Cyp39a1; mCYP39A1", "protein_names_uniprotkb": "24-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.26; Cytochrome P450 39A1; Oxysterol 7-alpha-hydroxylase; mCYP39A1", "protein_names_refseq": "24-hydroxycholesterol 7-alpha-hydroxylase isoform 1; 24-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P450, 39a1 (oxysterol 7alpha-hydroxylase); oxysterol 7-alpha-hydroxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56050); (R-MMU-193775); (R-MMU-211976)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10748047;21750661;34428180;36210013", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10748047)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.26;1.14.14.29;1.14.14.23", "go_molecular_function": "GO:0008387 steroid 7-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008395 steroid hydroxylase activity;GO:0033782 24S-hydroxycholesterol 7-alpha-hydroxylase activity", "go_cellular_component": "GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0042632 cholesterol homeostasis;GO:0007586 digestion;GO:0006707 cholesterol catabolic process;GO:0030573 bile acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JKJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18608-1", "uniprot_id": "HMGN1_MOUSE", "mass": 10152.0, "length": 96, "protein_name": "Non-histone chromosomal protein HMG-14", "gene_name": "Hmgn1", "organism": "Mouse", "refseq_name": "non-histone chromosomal protein HMG-14", "refseq_ac": "NP_032277", "gene_names_uniprotkb": "Hmgn1; Hmg-14; Hmg14", "gene_names_refseq": "HMG-14; Hmg14; Hmgn1", "protein_names_uniprotkb": "Non-histone chromosomal protein HMG-14; High mobility group nucleosome-binding domain-containing protein 1", "protein_names_refseq": "high mobility group nucleosome-binding domain-containing protein 1; high mobility group protein 14; non-histone chromosomal protein HMG-14", "tax_id": 10090, "disease": "", "pathway": " (mmu:15312)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15327773;17242355;21183079;21750661;23806337;2402471;26495903;3342876;34428180;37950483;38181856;38284254;7925294", "class_list": "", "function": "Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2., [UniProtKB, PubMed]; Chromatin binding protein HMGN1 promotes HBV cccDNA transcription and replication by regulating the phosphorylation of histone 3., [RefSeq, PubMed]; Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins., [RefSeq, PubMed]; [High mobility group nucleosome binding protein 1 (HMGN1) induces activation of mouse BV2 microglia and upregulates their pro-inflammatory mediator expression by activating TLR4/MyD88/NF-kappaB p65/IKK-beta signal pathway]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5HZY9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0050678 regulation of epithelial cell proliferation;GO:0000720 pyrimidine dimer repair by nucleotide-excision repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P18608-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54869-1", "uniprot_id": "HMCS2_MOUSE", "mass": 56823.0, "length": 508, "protein_name": "Hydroxymethylglutaryl-CoA synthase, mitochondrial", "gene_name": "Hmgcs2", "organism": "Mouse", "refseq_name": "hydroxymethylglutaryl-CoA synthase, mitochondrial precursor", "refseq_ac": "NP_032282", "gene_names_uniprotkb": "Hmgcs2", "gene_names_refseq": "1300002P16; Hmgcs2; mHS", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA synthase, mitochondrial; 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, mitochondrial precursor; hydroxymethylglutaryl-CoA synthase, mitochondrial", "tax_id": 10090, "disease": "HMG-CoA synthase 2 deficiency (Disease Ontology:DOID:0081168); extrahepatic cholestasis (Disease Ontology:DOID:13619); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15360); (R-MMU-77111); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17208939;21183079;22645316;23576753;23806337;24315375;31616917;34428180;37453647;38658970;7851882", "class_list": "", "function": "Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate., [UniProtKB, PubMed]; Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64740;Q9DBK1;Q9DBM4", "ec_number_list": "3.5.3.1;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;3.1.2.-;3.1.2.2;1.1.1.37;4.98.1.1;1.4.1.3;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;2.7.11.2;6.1.1.5;2.7.1.23;3.4.21.53;5.6.2.3;2.3.1.9;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;1.2.4.1;2.8.3.5;2.3.1.41;1.3.8.5;1.3.8.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004421 hydroxymethylglutaryl-CoA synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001889 liver development;GO:0007584 response to nutrient;GO:0032869 cellular response to insulin stimulus;GO:0042594 response to starvation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P54869-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00547-1", "uniprot_id": "HMMR_MOUSE", "mass": 91785.0, "length": 794, "protein_name": "Hyaluronan mediated motility receptor", "gene_name": "Hmmr", "organism": "Mouse", "refseq_name": "hyaluronan mediated motility receptor", "refseq_ac": "NP_038580", "gene_names_uniprotkb": "Hmmr; Ihabp; Rhamm", "gene_names_refseq": "AA386826; CD168; Hmmr; Rhamm", "protein_names_uniprotkb": "Hyaluronan mediated motility receptor; Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility", "protein_names_refseq": "hyaluronan mediated motility receptor; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motility", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:15366); (R-MMU-2142845); (R-MMU-2160916); (R-MMU-8854518)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "1376732;22666460;25428506;25605945;28135057;31219806;31338967;34428180;37075860;37405956;38838151;38904660;7518470;7590272;9556628;9601097;9845361;9889313", "class_list": "glycogene", "function": "HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression., [RefSeq, PubMed]; HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing., [RefSeq, PubMed]; Receptor for hyaluronic acid (HA) (PubMed:1376732). Involved in cell motility (PubMed:1376732). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenesis (PubMed:22666460)., [UniProtKB, PubMed, PubMed]; Single-cell transcriptomic analysis identifies a highly replicating Cd168[+] skeletal stem/progenitor cell population in mouse long bones., [RefSeq, PubMed]; The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q5NC88", "ec_number_list": "", "go_molecular_function": "GO:0005540 hyaluronic acid binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q00547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZR5-1", "uniprot_id": "HIPK2_MOUSE", "mass": 130498.0, "length": 1196, "protein_name": "Homeodomain-interacting protein kinase 2", "gene_name": "Hipk2", "organism": "Mouse", "refseq_name": "homeodomain-interacting protein kinase 2 isoform 1", "refseq_ac": "NP_001129537", "gene_names_uniprotkb": "Hipk2; Nbak1; Stank", "gene_names_refseq": "1110014O20Rik; B230339E18Rik; Hipk2; Stank", "protein_names_uniprotkb": "Homeodomain-interacting protein kinase 2; 2.7.11.1; Nuclear body-associated kinase 1; Sialophorin tail-associated nuclear serine/threonine-protein kinase", "protein_names_refseq": "homeodomain-interacting protein kinase 2 isoform 1; nuclear body-associated kinase 1; sialophorin tail-associated nuclear serine/threonine-protein kinase", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:15258); (R-MMU-3899300); (R-MMU-6804756); (R-MMU-8939243); (R-MMU-9022692)", "pathway_count": 5, "publication_count": 32, "publication_id_list": "10535925;11078605;11267674;11593421;11780126;11798164;14567915;14990717;15082531;15492043;15526030;16917507;19714248;20231426;20307497;20579985;20637728;21183079;21750661;22517741;23485397;27321923;30084848;30779550;34428180;36210013;38147784;38512421;39079624;40885482;40997131;9748262", "class_list": "", "function": "HIPK2 C-terminal domain inhibits NF-kappaB signaling and renal inflammation in kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (By similarity). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O88905;Q99P45;Q99P46;Q9D2E6;Q9D474;Q9EQL2;Q9QZR4", "ec_number_list": "2.7.11.1;2.7.11.25;2.3.1.48;2.3.1.-;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.3.2.-;2.7.11.39;2.7.11.31;3.6.5.-;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;5.2.1.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0030878 thyroid gland development;GO:0050882 voluntary musculoskeletal movement;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q9QZR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55091-1", "uniprot_id": "IMPCT_MOUSE", "mass": 36276.0, "length": 318, "protein_name": "Protein IMPACT", "gene_name": "Impact", "organism": "Mouse", "refseq_name": "protein IMPACT isoform 1", "refseq_ac": "NP_032404", "gene_names_uniprotkb": "Impact", "gene_names_refseq": "E430016J11Rik; Impact", "protein_names_uniprotkb": "Protein IMPACT; Imprinted and ancient gene protein", "protein_names_refseq": "imprinted and ancient gene protein; protein IMPACT isoform 1; protein IMPACT", "tax_id": 10090, "disease": "", "pathway": " (mmu:16210)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11116084;15871461;15937339;18260151;19131326;21183079;21750661;22404850;23447528;24333428;25605945;28135057;31166980;37507081;9256468", "class_list": "", "function": "Results indicate that IMPACT contributes to GCN2-dependent and -independent mechanisms involved in the regulation of autonomic functions in response to energy availability. Publication Status: Online-Only, [RefSeq, PubMed]; This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase., [RefSeq, PubMed]; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis (PubMed:15937339, PubMed:23447528, PubMed:24333428). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (PubMed:15937339, PubMed:23447528). Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth (PubMed:23447528)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUR6;Q9EQH0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0043022 ribosome binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0045666 positive regulation of neuron differentiation;GO:0001933 negative regulation of protein phosphorylation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O55091-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15247-1", "uniprot_id": "IL9_MOUSE", "mass": 16075.0, "length": 144, "protein_name": "Interleukin-9", "gene_name": "Il9", "organism": "Mouse", "refseq_name": "interleukin-9 precursor", "refseq_ac": "NP_032399", "gene_names_uniprotkb": "Il9", "gene_names_refseq": "Il-9; Il9; P40", "protein_names_uniprotkb": "Interleukin-9; Cytokine P40; IL-9; T-cell growth factor P40", "protein_names_refseq": "T-cell growth factor P40; cytokine P40; interleukin-9 precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); adult respiratory distress syndrome (Disease Ontology:DOID:11394); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:16198); (R-MMU-8985947)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10464327;11070175;12704113;19433802;1971295;2145361;2521242;2528451;3137580;38042840;38271093;7718508", "class_list": "", "function": "Interleukin-9 production by type 2 innate lymphoid cells induces Paneth cell metaplasia and small intestinal remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:11070175, PubMed:19433802). Affects intestinal epithelial permeability and adaptive immunity (PubMed:12704113). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells (PubMed:11070175, PubMed:19433802). Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG (PubMed:2145361, PubMed:7718508). Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs (PubMed:10464327). Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5 (PubMed:10464327)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; P40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005140 interleukin-9 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0030307 positive regulation of cell growth;GO:0050730 regulation of peptidyl-tyrosine phosphorylation;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P15247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20109-1", "uniprot_id": "IL13_MOUSE", "mass": 14108.0, "length": 131, "protein_name": "Interleukin-13", "gene_name": "Il13", "organism": "Mouse", "refseq_name": "interleukin-13 precursor", "refseq_ac": "NP_032381", "gene_names_uniprotkb": "Il13; Il-13", "gene_names_refseq": "Il-13; Il13", "protein_names_uniprotkb": "Interleukin-13; IL-13; T-cell activation protein P600", "protein_names_refseq": "T-cell activation protein P600; interleukin-13 precursor", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); respiratory allergy (Disease Ontology:DOID:0060496); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); lipoid nephrosis (Disease Ontology:DOID:10966); prostatic hypertrophy (Disease Ontology:DOID:11132); allergic conjunctivitis (Disease Ontology:DOID:11204); pulmonary edema (Disease Ontology:DOID:11396); onchocerciasis (Disease Ontology:DOID:11678); allergic disease (Disease Ontology:DOID:1205); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); peptic esophagitis (Disease Ontology:DOID:13976); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); multiple sclerosis (Disease Ontology:DOID:2377); dermatitis (Disease Ontology:DOID:2723); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); purpura (Disease Ontology:DOID:3326); mastocytosis (Disease Ontology:DOID:350); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); milk allergy (Disease Ontology:DOID:4376); egg allergy (Disease Ontology:DOID:4377); peanut allergy (Disease Ontology:DOID:4378); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); pneumonia (Disease Ontology:DOID:552); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); extrinsic allergic alveolitis (Disease Ontology:DOID:841); localized scleroderma (Disease Ontology:DOID:8472); lung disease (Disease Ontology:DOID:850); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:16163); (R-MMU-6785807)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15361238;24220297;2521353;25847241;29305434;29467919;34789557;34795444;8871614", "class_list": "", "function": "Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:15361238). Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (PubMed:34789557). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:34795444, PubMed:8871614). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:29305434). Induces inflammatory response in esophageal epithelium which results in a dysregulation of desmosome intercellular adhesion junctions, via down-regulation of DSG1 (PubMed:24220297)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005144 interleukin-13 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:2000231 positive regulation of pancreatic stellate cell proliferation;GO:0043032 positive regulation of macrophage activation;GO:0010155 regulation of proton transport;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20109-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXY6-1", "uniprot_id": "ILF2_MOUSE", "mass": 43062.0, "length": 390, "protein_name": "Interleukin enhancer-binding factor 2", "gene_name": "Ilf2", "organism": "Mouse", "refseq_name": "interleukin enhancer-binding factor 2", "refseq_ac": "NP_080650", "gene_names_uniprotkb": "Ilf2; Nf45", "gene_names_refseq": "6230405A16Rik; Ilf2; TEG-267; Tex261; Tex267", "protein_names_uniprotkb": "Interleukin enhancer-binding factor 2; Nuclear factor of activated T-cells 45 kDa", "protein_names_refseq": "interleukin enhancer-binding factor 2; nuclear factor of activated T-cells 45 kDa; testis expressed gene 267", "tax_id": 10090, "disease": "", "pathway": " (mmu:67781); (R-MMU-6798695); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10574923;11804788;24129315;25428506;28487382;29187734;33300544;34428180;7519613", "class_list": "", "function": "Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:10574923). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71 (By similarity) (PubMed:10574923)., [UniProtKB, UniProtKB, PubMed]; Data support a model in which NF45, NF90, and NF110 operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U083;Q5RKG0;Q8CCY9;Q99KS3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CXY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10749-1", "uniprot_id": "IL1B_MOUSE", "mass": 30931.0, "length": 269, "protein_name": "Interleukin-1 beta", "gene_name": "Il1b", "organism": "Mouse", "refseq_name": "interleukin-1 beta", "refseq_ac": "NP_032387", "gene_names_uniprotkb": "Il1b", "gene_names_refseq": "IL-1beta; Il-1b; Il1b", "protein_names_uniprotkb": "Interleukin-1 beta; IL-1 beta", "protein_names_refseq": "IL-1 beta; interleukin 1b; interleukin-1 beta", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); colitis (Disease Ontology:DOID:0060180); alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); urinary tract infection (Disease Ontology:DOID:0080784); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); keratoconus (Disease Ontology:DOID:10126); dry eye syndrome (Disease Ontology:DOID:10140); thalassemia (Disease Ontology:DOID:10241); pleurisy (Disease Ontology:DOID:10247); common cold (Disease Ontology:DOID:10459); stomach cancer (Disease Ontology:DOID:10534); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); hydronephrosis (Disease Ontology:DOID:11111); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); varicocele (Disease Ontology:DOID:12337); Graves' disease (Disease Ontology:DOID:12361); paracoccidioidomycosis (Disease Ontology:DOID:12662); agranulocytosis (Disease Ontology:DOID:12987); retinopathy of prematurity (Disease Ontology:DOID:13025); crescentic glomerulonephritis (Disease Ontology:DOID:13139); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); hypolipoproteinemia (Disease Ontology:DOID:1387); polyneuropathy (Disease Ontology:DOID:1389); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); thrombocytopenia (Disease Ontology:DOID:1588); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); hepatitis C (Disease Ontology:DOID:1883); dental caries (Disease Ontology:DOID:216); thrombocytosis (Disease Ontology:DOID:2228); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); endophthalmitis (Disease Ontology:DOID:4692); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); cochlear disease (Disease Ontology:DOID:5463); pneumonia (Disease Ontology:DOID:552); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); cholesteatoma (Disease Ontology:DOID:869); vascular dementia (Disease Ontology:DOID:8725); bacterial pneumonia (Disease Ontology:DOID:874); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); status asthmaticus (Disease Ontology:DOID:9362); epididymitis (Disease Ontology:DOID:9402); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); bronchiectasis (Disease Ontology:DOID:9563); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16176); (R-MMU-448706); (R-MMU-5620971); (R-MMU-5660668); (R-MMU-9020702); (R-MMU-9960519); (R-MMU-9960525)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "16407890;17284521;17641058;1807351;27802388;2967326;30084848;33723046;34428180;3491144;3492706", "class_list": "", "function": "Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 124, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2M4J6", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0030141 secretory granule;GO:0005764 lysosome", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0070164 negative regulation of adiponectin secretion;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0070498 interleukin-1-mediated signaling pathway;GO:0050691 regulation of defense response to virus by host", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P10749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1E3-1", "uniprot_id": "IKBA_MOUSE", "mass": 35071.0, "length": 314, "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "Nfkbia", "organism": "Mouse", "refseq_name": "NF-kappa-B inhibitor alpha", "refseq_ac": "NP_035037", "gene_names_uniprotkb": "Nfkbia; Ikba", "gene_names_refseq": "Nfkbia; Nfkbi", "protein_names_uniprotkb": "NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha", "protein_names_refseq": "I(Kappa)B(alpha); I-kappa-B-alpha; I-kappaBalpha; NF-kappa-B inhibitor alpha; ikB-alpha; ikappaBalpha; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); childhood-onset asthma (Disease Ontology:DOID:0080815); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); ectodermal dysplasia and immunodeficiency 2 (Disease Ontology:DOID:0081079); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); nephrotic syndrome (Disease Ontology:DOID:1184); alcoholic hepatitis (Disease Ontology:DOID:12351); Sjogren's syndrome (Disease Ontology:DOID:12894); lung cancer (Disease Ontology:DOID:1324); diarrhea (Disease Ontology:DOID:13250); toxic shock syndrome (Disease Ontology:DOID:14115); hepatitis C (Disease Ontology:DOID:1883); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); glioblastoma (Disease Ontology:DOID:3068); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastritis (Disease Ontology:DOID:4029); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); collagen disease (Disease Ontology:DOID:854); Hodgkin's lymphoma (Disease Ontology:DOID:8567); multiple myeloma (Disease Ontology:DOID:9538); encephalitis (Disease Ontology:DOID:9588); pulmonary emphysema (Disease Ontology:DOID:9675); toxoplasmosis (Disease Ontology:DOID:9965)", "pathway": " (mmu:18035); (R-MMU-1169091); (R-MMU-1810476); (R-MMU-202424); (R-MMU-209560); (R-MMU-2871837); (R-MMU-445989); (R-MMU-4755510); (R-MMU-5607764); (R-MMU-5689880); (R-MMU-9020702); (R-MMU-933542); (R-MMU-9860927)", "pathway_count": 13, "publication_count": 37, "publication_id_list": "10097128;10199915;10421793;10429205;10514433;10669746;10947072;11023547;11502888;11739551;12177064;12403772;12911789;14991073;15611577;15695559;15922723;16388856;17785622;20173027;20872791;22445657;23503581;25671697;26492364;29175419;30084848;31219806;33975230;34203471;34428180;36210013;38697463;7565683;7878466;9859996;9990853", "class_list": "", "function": "Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:10097128, PubMed:9990853). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:10097128, PubMed:7878466, PubMed:9990853)., [UniProtKB, PubMed, PubMed, PubMed]; Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9W9;Q3UB40;Q80ZX5", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0033256 I-kappaB/NF-kappaB complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070498 interleukin-1-mediated signaling pathway;GO:0010888 negative regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q9Z1E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70218-1", "uniprot_id": "M4K1_MOUSE", "mass": 91535.0, "length": 827, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase 1", "gene_name": "Map4k1", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 1 isoform 1", "refseq_ac": "NP_032305", "gene_names_uniprotkb": "Map4k1; Hpk1", "gene_names_refseq": "Hpk1; Map4k1; mHPK1", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase 1; 2.7.11.1; HPK; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1", "protein_names_refseq": "HPK; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; hematopoietic progenitor kinase 1; mitogen-activated protein kinase kinase kinase kinase 1 isoform 1", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:26411)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11509653;11514608;12130508;15100220;21183079;21750661;25605945;26495903;29187734;30282040;30913212;31209405;32631900;34428180;37140994;38828677;39627609;9003777", "class_list": "", "function": "Data provide novel findings that HKP1 kinase activity is critical in conferring suppressive functions of HPK1 in a wide range of immune cells including CD4+, CD8+, DC, NK to Tregs, and inactivation of kinase domain was sufficient to elicit robust anti-tumor immune responses. Publication Status: Online-Only, [RefSeq, PubMed]; HPK1 Dysregulation-Associated NK Cell Dysfunction and Defective Expansion Promotes Metastatic Melanoma Progression., [RefSeq, PubMed]; HPK1 Influences Regulatory T Cell Functions. Publication Status: Online-Only, [RefSeq, PubMed]; Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Hpk1 supports apoptosis of T lymphocytes by inhibiting the antiapoptotic action of NF-kappaB and inducing the proapoptotic activity of JNK., [RefSeq, PubMed]; Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix, [RefSeq, PubMed]; Results identify the importance of HPK1 kinase activity in the negative regulation of CD8 effector functions., [RefSeq, PubMed]; Serine/threonine-protein kinase, which plays a role in the response to environmental stress (By similarity). Appears to act upstream of the JUN N-terminal pathway (PubMed:9003777). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:9003777). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (PubMed:11509653)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3R0;Q99K62", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008283 cell population proliferation;GO:0035556 intracellular signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P70218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03391-1", "uniprot_id": "NMDE4_MOUSE", "mass": 142963.0, "length": 1323, "protein_name": "Glutamate receptor ionotropic, NMDA 2D", "gene_name": "Grin2d", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, NMDA 2D precursor", "refseq_ac": "NP_032198", "gene_names_uniprotkb": "Grin2d; GluN2D", "gene_names_refseq": "GluN2D; Grin2d; NMDAR2D; NR2D", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2D; GluN2D; Glutamate [NMDA] receptor subunit epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D", "protein_names_refseq": "GluRepsilon4; N-methyl D-aspartate receptor subtype 2D; glur epsilon 4; glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor ionotropic, NMDA 2D precursor; glutamate receptor ionotropic, NMDA 2D; ionotropic NMDA glutamate receptor epsilon 4 subunit type 2", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); developmental and epileptic encephalopathy 46 (Disease Ontology:DOID:0080456); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:14814); (R-MMU-438066); (R-MMU-5673001); (R-MMU-8849932); (R-MMU-9609736)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;1385220;21183079;21750661;24129315;25428506;30899004;31361958;35820727;7790891;8774946", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:1385220). Participates in synaptic plasticity for learning and memory formation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1385220, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "C9K0Z5", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0005261 monoatomic cation channel activity;GO:0004970 glutamate-gated receptor activity;GO:0016595 glutamate binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0001964 startle response;GO:0008344 adult locomotory behavior;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0060079 excitatory postsynaptic potential;GO:2000463 positive regulation of excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q03391-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D281-1", "uniprot_id": "NXP20_MOUSE", "mass": 61013.0, "length": 569, "protein_name": "Protein Noxp20", "gene_name": "Fam114a1", "organism": "Mouse", "refseq_name": "protein Noxp20", "refseq_ac": "NP_080943", "gene_names_uniprotkb": "Fam114a1; Noxp20", "gene_names_refseq": "1190001N04Rik; 9130005N14Rik; Fam114a1; Noxp20", "protein_names_uniprotkb": "Protein Noxp20; Nervous system overexpressed protein 20; Protein FAM114A1", "protein_names_refseq": "nervous system over-expressed protein 20; nervous system overexpressed protein 20; protein Noxp20", "tax_id": 10090, "disease": "", "pathway": " (mmu:68303)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17029606;21183079;21750661;25428506;28135057;31219806;34428180;34837888;35671117;36210013", "class_list": "", "function": "FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression., [RefSeq, PubMed]; May play a role in neuronal cell development., [UniProtKB]; The Noxp20 transcript encodes a putative protein with a predicted caspase recruitment domain. At embryonic days 12 and 15, Noxp20 is strongly expressed in the ventricular and intermediate zones of the brain and of the spinal cord., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMQ0;Q8R2U1;Q9D3K6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0038166 angiotensin-activated signaling pathway;GO:0048144 fibroblast proliferation;GO:0010761 fibroblast migration;GO:0072537 fibroblast activation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70313-1", "uniprot_id": "NOS3_MOUSE", "mass": 132916.0, "length": 1202, "protein_name": "Nitric oxide synthase 3", "gene_name": "Nos3", "organism": "Mouse", "refseq_name": "nitric oxide synthase 3", "refseq_ac": "NP_032739", "gene_names_uniprotkb": "Nos3; Ecnos", "gene_names_refseq": "2310065A03Rik; Nos-3; Nos3; eNOS; ecNOS", "protein_names_uniprotkb": "Nitric oxide synthase 3; 1.14.13.39; Constitutive NOS; EC-NOS; Endothelial NOS; NOS type III; NOSIII; Nitric oxide synthase, endothelial; cNOS; eNOS", "protein_names_refseq": "EC-NOS; NOS type III; NOSIII; cNOS; constitutive NOS; endothelial NOS; endothelial nitric oxide synthase; nitric oxide synthase 3; nitric oxide synthase, endothelial", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); cardiomyopathy (Disease Ontology:DOID:0050700); obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); respiratory allergy (Disease Ontology:DOID:0060496); polycystic kidney disease (Disease Ontology:DOID:0080322); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); essential hypertension (Disease Ontology:DOID:10825); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); intracranial aneurysm (Disease Ontology:DOID:10941); nephritis (Disease Ontology:DOID:10952); urinary bladder cancer (Disease Ontology:DOID:11054); pulmonary edema (Disease Ontology:DOID:11396); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); primary biliary cholangitis (Disease Ontology:DOID:12236); vulva cancer (Disease Ontology:DOID:1245); leiomyoma (Disease Ontology:DOID:127); telangiectasis (Disease Ontology:DOID:1272); retinopathy of prematurity (Disease Ontology:DOID:13025); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); Behcet's disease (Disease Ontology:DOID:13241); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); coronary artery disease (Disease Ontology:DOID:3393); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); macular retinal edema (Disease Ontology:DOID:4449); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); aortic valve disease (Disease Ontology:DOID:62); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); overnutrition (Disease Ontology:DOID:654); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); ileus (Disease Ontology:DOID:8440); retinal degeneration (Disease Ontology:DOID:8466); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); diabetic retinopathy (Disease Ontology:DOID:8947); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); central sleep apnea (Disease Ontology:DOID:9220); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); irritable bowel syndrome (Disease Ontology:DOID:9778); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18127); (R-MMU-1222556); (R-MMU-1474151); (R-MMU-203615); (R-MMU-203641); (R-MMU-203754); (R-MMU-392154); (R-MMU-5218920); (R-MMU-9009391); (R-MMU-9856530)", "pathway_count": 10, "publication_count": 25, "publication_id_list": "17242355;19131647;19654415;20852044;21183079;21454579;21750661;22081021;23291238;25428506;26269457;26598507;26660551;28011936;28562691;29030392;29379034;32364494;32653904;33908348;34428180;35820727;41476791;8764825;9843834", "class_list": "", "function": "Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 80, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O55056;Q7TSV7", "ec_number_list": "2.7.11.11;3.6.4.10;1.14.13.39;2.7.11.1;3.6.5.5;3.1.2.22;3.1.2.-;2.7.11.13;2.3.1.225;2.3.2.27", "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0034617 tetrahydrobiopterin binding;GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0003057 regulation of the force of heart contraction by chemical signal;GO:0014740 negative regulation of muscle hyperplasia;GO:0014806 smooth muscle hyperplasia;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P70313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35516-1", "uniprot_id": "NOTC2_MOUSE", "mass": 265633.0, "length": 2473, "protein_name": "Neurogenic locus notch homolog protein 2", "gene_name": "Notch2", "organism": "Mouse", "refseq_name": "neurogenic locus notch homolog protein 2 precursor", "refseq_ac": "NP_035058", "gene_names_uniprotkb": "Notch2", "gene_names_refseq": "N2; Notch2", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 2; Motch B; Notch 2", "protein_names_refseq": "Motch B; Notch gene homolog 2; neurogenic locus notch homolog protein 2 precursor; neurogenic locus notch homolog protein 2", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); brain cancer (Disease Ontology:DOID:1319); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Hajdu-Cheney syndrome (Disease Ontology:DOID:2736); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); Alagille syndrome (Disease Ontology:DOID:9245); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18129)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;10393120;11459941;11465105;11518718;15019995;17573339;18250455;18299578;18710934;19144319;21540332;21949356;22517741;25428506;26740625;27802388;28011936;30084848;30779550;31599954;32152506;33725478;34428180;35822049;35984892;37828378;37838775;40885482;7609614;8440332;8917536", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (PubMed:10393120). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:10393120, PubMed:18710934). Affects the implementation of differentiation, proliferation and apoptotic programs (PubMed:10393120, PubMed:18710934). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:18710934). Positively regulates self-renewal of liver cancer cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 14, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "G5E8J0;Q06008;Q60941", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding;GO:0051059 NF-kappaB binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0072574 hepatocyte proliferation;GO:0071228 cellular response to tumor cell;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "O35516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG93-1", "uniprot_id": "NUD15_MOUSE", "mass": 19576.0, "length": 170, "protein_name": "Nucleotide triphosphate diphosphatase NUDT15", "gene_name": "Nudt15", "organism": "Mouse", "refseq_name": "nucleotide triphosphate diphosphatase NUDT15", "refseq_ac": "NP_766115", "gene_names_uniprotkb": "Nudt15; Mth2", "gene_names_refseq": "6530403O17; A730068G11Rik; MTH2; Nudt15", "protein_names_uniprotkb": "Nucleotide triphosphate diphosphatase NUDT15; 3.6.1.68; 3.6.1.76; 3.6.1.9; MutT homolog 2; Nucleoside diphosphate-linked moiety X motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nudix hydrolase 15; Nudix motif 15; mMTH2", "protein_names_refseq": "7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; MutT homolog 2; nucleoside diphosphate-linked moiety X motif 15; nucleoside diphosphate-linked to another moiety X hydrolase 15; nucleotide triphosphate diphosphatase NUDT15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; nudix motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15", "tax_id": 10090, "disease": "poor metabolism of thiopurines 2 (Disease Ontology:DOID:0060996); neutropenia (Disease Ontology:DOID:1227); pancytopenia (Disease Ontology:DOID:12450); leukopenia (Disease Ontology:DOID:615)", "pathway": " (mmu:214254); (R-MMU-2393930); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12767940;19735921;31645647;32432673;37488179;39025986;8810257", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:12767940). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (By similarity). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:12767940). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (By similarity). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate. It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 redundancy factor [MTH2], [RefSeq, PubMed]; Nudt15-mediated inflammatory signaling contributes to divergent outcomes in leukemogenesis and hematopoiesis., [RefSeq, PubMed]; These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging., [RefSeq, PubMed]; Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15(R138C) knock-in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.62;3.6.1.64;3.1.4.1;3.6.1.9;3.6.1.-;3.6.1.77;3.6.1.17;3.6.1.58;3.6.1.68;3.6.1.76;3.1.3.-", "go_molecular_function": "GO:0044715 8-oxo-dGDP phosphatase activity;GO:0046872 metal ion binding;GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0047429 nucleoside triphosphate diphosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1901292 nucleoside phosphate catabolic process;GO:0000278 mitotic cell cycle;GO:0006195 purine nucleotide catabolic process;GO:0006203 dGTP catabolic process;GO:0042262 DNA protection", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BG93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0G9-1", "uniprot_id": "NU133_MOUSE", "mass": 128620.0, "length": 1155, "protein_name": "Nuclear pore complex protein Nup133", "gene_name": "Nup133", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup133", "refseq_ac": "NP_758492", "gene_names_uniprotkb": "Nup133", "gene_names_refseq": "Nup133; mermaid", "protein_names_uniprotkb": "Nuclear pore complex protein Nup133; 133 kDa nucleoporin; Nucleoporin Nup133", "protein_names_refseq": "133 kDa nucleoporin; nuclear pore complex protein Nup133; nucleoporin Nup133", "tax_id": 10090, "disease": "Galloway-Mowat syndrome 1 (Disease Ontology:DOID:0060364); nephrotic syndrome type 18 (Disease Ontology:DOID:0080393); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694)", "pathway": " (mmu:234865); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;23806337;24129315;25428506;25605945;29791854;30084848;30779550;31219806;31599954;34428180;34887587;36210013;37828378;39627609", "class_list": "", "function": "Involved in poly(A)+ RNA transport. Involved in nephrogenesis., [UniProtKB, UniProtKB]; Nup133 is dispensable for interphase and postmitotic nuclear pore complex scaffold assembly in pluripotent mouse embryonic stem cell. Erratum:[Cell Rep. 2018 Nov 13;25(7):1994. doi: 10.1016/j.celrep.2018.11.012. PMID: 30428363], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QLJ8", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0000776 kinetochore", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0072006 nephron development;GO:0006999 nuclear pore organization;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8R0G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43267-1", "uniprot_id": "SOX15_MOUSE", "mass": 25311.0, "length": 231, "protein_name": "Transcription factor SOX-15", "gene_name": "Sox15", "organism": "Mouse", "refseq_name": "transcription factor SOX-15", "refseq_ac": "NP_033261", "gene_names_uniprotkb": "Sox15; Sox-15; Sox16", "gene_names_refseq": "Sox15; Sox16", "protein_names_uniprotkb": "Transcription factor SOX-15; SRY-box transcription factor 15", "protein_names_refseq": "SRY (sex determining region Y)-box 16; SRY-box containing gene 15; SRY-box containing gene 16; SRY-box transcription factor 15; protein SOX-15; protein SOX-16; transcription factor SOX-15", "tax_id": 10090, "disease": "", "pathway": " (mmu:20670)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10524236;10821863;15367664;15863505;16759287;17363903;18393569;36852467;8479922;8921394", "class_list": "", "function": "These results suggest that the region from -297 to -8 of the Sox15 gene contains three distinct cis-elements, and that these sequences were conserved among eutherian mammals during vertebrate evolution., [RefSeq, PubMed]; Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (PubMed:10821863, PubMed:15863505, PubMed:16759287, PubMed:17363903). Acts as a transcriptional activator and repressor (PubMed:10821863, PubMed:15863505, PubMed:16759287). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (PubMed:15863505). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (PubMed:17363903). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (PubMed:10821863). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (PubMed:16759287). Regulates transcription of HRC via binding to its proximal enhancer region (PubMed:15863505). Involved in skeletal muscle regeneration (PubMed:15367664, PubMed:17363903). Also plays a role in the development of myogenic precursor cells (PubMed:15367664)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O70204;P70418;Q62246;Q62247;Q91V00;Q91V43;Q920T1;Q9JLG2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P43267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02085-1", "uniprot_id": "SNAI1_MOUSE", "mass": 29190.0, "length": 264, "protein_name": "Zinc finger protein SNAI1", "gene_name": "Snai1", "organism": "Mouse", "refseq_name": "zinc finger protein SNAI1", "refseq_ac": "NP_035557", "gene_names_uniprotkb": "Snai1; Sna", "gene_names_refseq": "Sna1; Snai1; Snail1; Snail; Sna", "protein_names_uniprotkb": "Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna", "protein_names_refseq": "snail homolog 1; zinc finger protein SNAI1", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); dilated cardiomyopathy (Disease Ontology:DOID:12930); skin cancer (Disease Ontology:DOID:4159); colorectal cancer (Disease Ontology:DOID:9256); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (mmu:20613)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10655586;11689706;12832491;1295727;1483390;18331720;19386897;19923321;19955572;21577210;22276203;24239292;30150766;9271672", "class_list": "", "function": "Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (By similarity). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'. In addition, may also activate the CDKN2B promoter by itself., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019900 kinase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0060806 negative regulation of cell differentiation involved in embryonic placenta development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q02085-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63166-1", "uniprot_id": "SUMO1_MOUSE", "mass": 11557.0, "length": 101, "protein_name": "Small ubiquitin-related modifier 1", "gene_name": "Sumo1", "organism": "Mouse", "refseq_name": "small ubiquitin-related modifier 1", "refseq_ac": "NP_033486", "gene_names_uniprotkb": "Sumo1; Smt3c; Smt3h3; Ubl1", "gene_names_refseq": "GMP1; PIC1; SENTRIN; SMT3H3; SMT3; SMTP3; SUMO-1; Smt3C; Sumo1; Ubl1", "protein_names_uniprotkb": "Small ubiquitin-related modifier 1; SMT3 homolog 3; SUMO-1; Smt3C; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C", "protein_names_refseq": "SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; SUMO-1 related peptidase; small ubiquitin-related modifier 1; ubiquitin-homology domain protein PIC1; ubiquitin-like 1; ubiquitin-like protein SMT3C", "tax_id": 10090, "disease": "orofacial cleft 10 (Disease Ontology:DOID:0080403); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:22218); (R-MMU-3065676); (R-MMU-3065678); (R-MMU-3065679); (R-MMU-3108214); (R-MMU-3232118); (R-MMU-3232142); (R-MMU-3899300); (R-MMU-4085377); (R-MMU-4090294); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-4655427); (R-MMU-4755510); (R-MMU-5693565); (R-MMU-5696395); (R-MMU-877312); (R-MMU-8866904); (R-MMU-9615933); (R-MMU-9793242); (R-MMU-9856649); (R-MMU-9937850)", "pathway_count": 23, "publication_count": 12, "publication_id_list": "15225651;15767674;16990542;18681895;19131326;21750661;25153642;31088288;37520526;37683133;40997131;9465300", "class_list": "", "function": "SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells., [RefSeq, PubMed]; Splenic SUMO1 controls systemic inflammation in experimental sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P55856;Q3TX92;Q93068", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0015459 potassium channel regulator activity;GO:0031625 ubiquitin protein ligase binding;GO:1990381 ubiquitin-specific protease binding;GO:0044389 ubiquitin-like protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0030578 PML body organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0006355 regulation of DNA-templated transcription;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P63166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60803-1", "uniprot_id": "TRAF3_MOUSE", "mass": 64294.0, "length": 567, "protein_name": "TNF receptor-associated factor 3", "gene_name": "Traf3", "organism": "Mouse", "refseq_name": "TNF receptor-associated factor 3 isoform a", "refseq_ac": "NP_035762", "gene_names_uniprotkb": "Traf3; Cap-1; Craf1; Trafamn", "gene_names_refseq": "CAP-1; CD40bp; CRAF1; LAP1; T-BAM; TRAFAMN; Traf3; amn", "protein_names_uniprotkb": "TNF receptor-associated factor 3; 2.3.2.27; CD40 receptor-associated factor 1; CD40-binding protein; CD40BP; CRAF1; RING-type E3 ubiquitin transferase TRAF3", "protein_names_refseq": "CD40 receptor-associated factor 1; CD40-binding protein; RING-type E3 ubiquitin transferase TRAF3; TNF receptor-associated factor 3 isoform a", "tax_id": 10090, "disease": "immunodeficiency 132B (Disease Ontology:DOID:0061097); immunodeficiency 132A (Disease Ontology:DOID:0061101)", "pathway": " (mmu:22031); (R-MMU-5668541); (R-MMU-5676594); (R-MMU-5689896); (R-MMU-936964); (R-MMU-9824878)", "pathway_count": 6, "publication_count": 27, "publication_id_list": "16306936;16306937;17015635;17158868;17723217;18313334;18849341;18997792;18997794;19228877;19898473;21750661;23150880;23334419;23542741;23871208;26029823;26305951;26474655;30579117;34428180;37207205;38527707;38651786;7533327;8660894;8934568", "class_list": "", "function": "Circular RNA circEfnb2 promotes cell injury after cerebral infarction by sponging miR-202-5p and regulating TRAF3 expression., [RefSeq, PubMed]; Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:17015635). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:19898473, PubMed:23150880, PubMed:23871208, PubMed:26305951). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines (PubMed:16306937). Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance. Also acts as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development (PubMed:17723217). Required for normal antibody isotype switching from IgM to IgG (PubMed:19228877). Plays a role T-cell dependent immune responses (PubMed:8934568). Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment., [RefSeq, PubMed]; The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RPW3;Q62380", "ec_number_list": "2.3.2.27;3.4.19.12;3.4.25.1;3.1.3.48;3.2.2.-;3.2.2.6;3.6.5.2;2.7.11.10;2.7.11.25;2.7.11.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0031996 thioesterase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0010008 endosome membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0032648 regulation of interferon-beta production;GO:0007166 cell surface receptor signaling pathway;GO:0006915 apoptotic process;GO:0030162 regulation of proteolysis;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q60803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61471-1", "uniprot_id": "TOB1_MOUSE", "mass": 40056.0, "length": 362, "protein_name": "Protein Tob1", "gene_name": "Tob1", "organism": "Mouse", "refseq_name": "protein Tob1", "refseq_ac": "NP_033453", "gene_names_uniprotkb": "Tob1; Tob; Trob", "gene_names_refseq": "Tob1; Tob; Trob", "protein_names_uniprotkb": "Protein Tob1; Transducer of erbB-2 1", "protein_names_refseq": "protein Tob1; transducer of erbB2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22057)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12050114;15235587;18250455;19224205;20173027;25428506;25428507;25605945;31219806;32782141;32848054;34428180;35822049;36852467;38165569;38512977;9210596", "class_list": "", "function": "A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay., [UniProtKB, UniProtKB]; Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation, [RefSeq, PubMed]; TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q640M3", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0030971 receptor tyrosine kinase binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0060390 regulation of SMAD protein signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0030514 negative regulation of BMP signaling pathway;GO:0017148 negative regulation of translation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06800-4", "uniprot_id": "PTPRC_MOUSE", "mass": 144837.0, "length": 1293, "protein_name": "Receptor-type tyrosine-protein phosphatase C", "gene_name": "Ptprc", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase C isoform 1 precursor", "refseq_ac": "NP_001104786", "gene_names_uniprotkb": "Ptprc; Ly-5", "gene_names_refseq": "B220; CD45R; Cd45; L-CA; Ly-5; Lyt-4; Ptprc; T200; loc", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase C; 3.1.3.48; L-CA; Leukocyte common antigen; Ly-5; Lymphocyte antigen 5; T200", "protein_names_refseq": "leukocyte common antigen; lymphocyte antigen 5; lymphocyte common antigen; receptor-type tyrosine-protein phosphatase C isoform 1 precursor; receptor-type tyrosine-protein phosphatase C", "tax_id": 10090, "disease": "severe combined immunodeficiency 105 (Disease Ontology:DOID:0061074); hypertension (Disease Ontology:DOID:10763); multiple sclerosis (Disease Ontology:DOID:2377); severe combined immunodeficiency (Disease Ontology:DOID:627); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:19264); (R-MMU-202427); (R-MMU-416700); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10415030;16075062;1822988;19144319;1932742;21183079;2522930;25428506;26495903;26740625;27802388;2944116;2948186;30084848;3037546;30779550;3211131;32152506;33725478;3417340;34428180;3570377;3864163;39627609;9148925", "class_list": "", "function": "Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 9, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 6, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "E9QLT5;Q61812;Q61813;Q61814;Q61815;Q78EF1;S4R1S4;S4R2V1", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.10.2;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.6.5.2;2.7.10.4;3.4.11.2;7.6.2.-;3.4.24.11;3.1.3.27;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.1.3.5;3.1.3.21;3.1.3.18;3.6.1.-", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0045202 synapse", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0001779 natural killer cell differentiation;GO:0002711 positive regulation of T cell mediated immunity;GO:0050857 positive regulation of antigen receptor-mediated signaling pathway;GO:0016311 dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P06800-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIG4-1", "uniprot_id": "FBX28_MOUSE", "mass": 40978.0, "length": 368, "protein_name": "F-box only protein 28", "gene_name": "Fbxo28", "organism": "Mouse", "refseq_name": "F-box only protein 28", "refseq_ac": "NP_780336", "gene_names_uniprotkb": "Fbxo28; D1Ertd578e; Kiaa0483", "gene_names_refseq": "4833428J17Rik; 5730505P19Rik; D1Ertd578e; Fbx28; Fbxo28; mKIAA0483", "protein_names_uniprotkb": "F-box only protein 28", "protein_names_refseq": "F-box only protein 28", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 100 (Disease Ontology:DOID:0070386)", "pathway": " (mmu:67948)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;30084848;31219806;38696123;38960234", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, promoting ubiquitination and proteasomal degradation of specific target proteins including TOP2A, RAB27A or itself. Regulates topoisomerase IIalpha/TOP2A decatenation activity and plays an important role in maintaining genomic stability (By similarity). Plays a role in lipid metabolism and inflammation through the ubiquitinated degradation of RAB27A (PubMed:38696123). Strongly regulates beta-cell survival without having any significant independent effect on insulin secretion (By similarity). Plays an essential role in spindle morphology and actin-based spindle migration probably through the ARPC2/ARP3 signaling pathway (PubMed:38960234)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS97;Q7TMH9;Q8BIF6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BIG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2W0-1", "uniprot_id": "FXYD4_MOUSE", "mass": 9269.0, "length": 88, "protein_name": "FXYD domain-containing ion transport regulator 4", "gene_name": "Fxyd4", "organism": "Mouse", "refseq_name": "FXYD domain-containing ion transport regulator 4 precursor", "refseq_ac": "NP_001166843", "gene_names_uniprotkb": "Fxyd4", "gene_names_refseq": "0610008I02Rik; Chif; Fxyd4", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 4; CHIF; Channel-inducing factor", "protein_names_refseq": "FXYD domain-containing ion transport regulator 4 precursor; channel inducing factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:108017); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12167609;14976412;21750661", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Increases the apparent affinity of the transporter for Na(+) and increases NKA activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Corticosteroid hormone induced factor (CHIF) is a small epithelial-specific protein regulated by aldosterone and K+ intake., [RefSeq, PubMed]; Data are consistent with an effect of CHIF on the Na(+)-K(+)-ATPase specific to the outer and inner medullary duct, [RefSeq, PubMed]; This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0005267 potassium channel activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005890 sodium:potassium-exchanging ATPase complex;GO:0016020 membrane", "go_biological_process": "GO:0006812 monoatomic cation transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0006813 potassium ion transport;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D2W0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPX5-1", "uniprot_id": "FXL12_MOUSE", "mass": 37231.0, "length": 326, "protein_name": "F-box/LRR-repeat protein 12", "gene_name": "Fbxl12", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 12 isoform b", "refseq_ac": "NP_001002846", "gene_names_uniprotkb": "Fbxl12; Fbl12", "gene_names_refseq": "3110048D16Rik; Fbl12; Fbxl12", "protein_names_uniprotkb": "F-box/LRR-repeat protein 12; F-box and leucine-rich repeat protein 12; F-box protein FBL12", "protein_names_refseq": "F-box protein FBL12; F-box protein containing leucine repeats 12; F-box/LRR-repeat protein 12 isoform b; F-box/LRR-repeat protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:30843); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10531037;21750661;26999371;31219806;34428180", "class_list": "", "function": "Study investigated the role of FBXL12 in T-cell development by examination of FBXL12-null mice, finding that the FBXL12-ALDH3 axis plays a key role in regulation of the positive selection of T cells., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVH7;Q8CDX0;Q9CY04;Q9QZN5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CG64-1", "uniprot_id": "FKRP_MOUSE", "mass": 54852.0, "length": 494, "protein_name": "Ribitol 5-phosphate transferase FKRP", "gene_name": "Fkrp", "organism": "Mouse", "refseq_name": "ribitol 5-phosphate transferase FKRP", "refseq_ac": "NP_775606", "gene_names_uniprotkb": "Fkrp", "gene_names_refseq": "A830029B19Rik; Fkrp; LGMD1I; MDC1C", "protein_names_uniprotkb": "Ribitol 5-phosphate transferase FKRP; 2.4.2.-; 2.7.8.-; Fukutin-related protein; Ribitol-5-phosphate transferase", "protein_names_refseq": "ribitol 5-phosphate transferase FKRP; ribitol-5-phosphate transferase", "tax_id": 10090, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); autosomal recessive limb-girdle muscular dystrophy type 2I (Disease Ontology:DOID:0110299); muscular dystrophy-dystroglycanopathy type B5 (Disease Ontology:DOID:0110635); congenital muscular dystrophy-dystroglycanopathy type A5 (Disease Ontology:DOID:0111241); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); dilated cardiomyopathy (Disease Ontology:DOID:12930); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:243853); (R-MMU-9939291)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12471058;15837576;17452335;17554798;19155270;19900540;20675713;21750661;23591631;26923585;29416295;31219806;38277301", "class_list": "glycogene", "function": "Basement membrane (BM) fragility may underlie abnormal phenotypes in fukutin-null embryos, and maintenance of BM function may require fukutin-mediated glycosylation of alpha-dystroglycan early in embryonic development., [RefSeq, PubMed]; Break Down of the Complexity and Inconsistency Between Levels of Matriglycan and Disease Phenotype in FKRP-Related Dystroglycanopathies: A Review and Model of Interpretation. Review article, [RefSeq, PubMed]; Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:26923585)., [UniProtKB, PubMed]; Data offer the first evidence of a fukutin-related protein (FKRP) complex in muscle and suggest that FKRP may influence the glycosylation status of dystroglycan from within the sarcolemmal dystrophin-glycoprotein complex, [RefSeq, PubMed]; Results suggest the generation of a mouse model for FKRP related muscular dystrophy requires a knock-down rather than a knock-in strategy in order to give rise to a disease phenotype., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJR3", "ec_number_list": "2.4.2.-;2.7.8.-;2.4.2.61;2.4.1.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0043236 laminin binding;GO:0002162 dystroglycan binding;GO:0016780 phosphotransferase activity, for other substituted phosphate groups", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060538 skeletal muscle organ development;GO:0097305 response to alcohol;GO:0001701 in utero embryonic development;GO:0003016 respiratory system process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CG64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R089-1", "uniprot_id": "FBRS_MOUSE", "mass": 49038.0, "length": 466, "protein_name": "Probable fibrosin-1", "gene_name": "Fbrs", "organism": "Mouse", "refseq_name": "probable fibrosin-1", "refseq_ac": "NP_034313", "gene_names_uniprotkb": "Fbrs; Fbs1; Fbs", "gene_names_refseq": "Fbrs; Fbs1; Fbs", "protein_names_uniprotkb": "Probable fibrosin-1", "protein_names_refseq": "fibrosin-1; probable fibrosin-1 long transcript protein; probable fibrosin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14123)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;24129315;40997131;7892239", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0048146 positive regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R089-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K064-1", "uniprot_id": "F174B_MOUSE", "mass": 16213.0, "length": 153, "protein_name": "Membrane protein FAM174B", "gene_name": "Fam174b", "organism": "Mouse", "refseq_name": "membrane protein FAM174B precursor", "refseq_ac": "NP_001156004", "gene_names_uniprotkb": "Fam174b", "gene_names_refseq": "Fam174b", "protein_names_uniprotkb": "Membrane protein FAM174B", "protein_names_refseq": "membrane protein FAM174B precursor; membrane protein FAM174B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100038347)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Essential for Golgi structural integrity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2NLC2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTJ4-1", "uniprot_id": "FIZ1_MOUSE", "mass": 52685.0, "length": 500, "protein_name": "Flt3-interacting zinc finger protein 1", "gene_name": "Fiz1", "organism": "Mouse", "refseq_name": "flt3-interacting zinc finger protein 1", "refseq_ac": "NP_001103798", "gene_names_uniprotkb": "Fiz1", "gene_names_refseq": "Fiz1; mFLJ00416", "protein_names_uniprotkb": "Flt3-interacting zinc finger protein 1", "protein_names_refseq": "flt3-interacting zinc finger protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23877)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10409713;12566383;15304385;18854042;20360400;21750661;28528544;31219806;34203471", "class_list": "", "function": "Addition of potent FLT3 inhibitors such as SU11248 to acute myeloid leukemia chemotherapy regimens could result in improved treatment results., [RefSeq, PubMed]; FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B lymphoblastic lymphomas., [RefSeq, PubMed]; Fiz1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W14;Q9CTG3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WTJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL70-1", "uniprot_id": "FANCA_MOUSE", "mass": 161213.0, "length": 1439, "protein_name": "Fanconi anemia group A protein homolog", "gene_name": "Fanca", "organism": "Mouse", "refseq_name": "Fanconi anemia group A protein homolog", "refseq_ac": "NP_058621", "gene_names_uniprotkb": "Fanca", "gene_names_refseq": "FACA; Fanca", "protein_names_uniprotkb": "Fanconi anemia group A protein homolog; Protein FACA", "protein_names_refseq": "Fanconi anemia group A protein homolog", "tax_id": 10090, "disease": "Fanconi anemia complementation group A (Disease Ontology:DOID:0111095); urinary bladder cancer (Disease Ontology:DOID:11054); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cervical cancer (Disease Ontology:DOID:4362); primary ovarian insufficiency (Disease Ontology:DOID:5426); skin melanoma (Disease Ontology:DOID:8923); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:14087); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10754110;10936049;21750661;22872234;31219806;34203471;34428180;36210013;36852467", "class_list": "", "function": "DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QKQ4;Q9ESU9;Q9ESV3;Q9ET44;Q9JL64;Q9JL65;Q9JL66;Q9JL67;Q9JL68;Q9JL69", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:2000348 regulation of CD40 signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0008584 male gonad development;GO:0050727 regulation of inflammatory response;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JL70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UWW6-1", "uniprot_id": "GA2L3_MOUSE", "mass": 74235.0, "length": 683, "protein_name": "GAS2-like protein 3", "gene_name": "Gas2l3", "organism": "Mouse", "refseq_name": "GAS2-like protein 3 isoform 1", "refseq_ac": "NP_001028503", "gene_names_uniprotkb": "Gas2l3", "gene_names_refseq": "8430435B07Rik; Gas2l3; Gm240", "protein_names_uniprotkb": "GAS2-like protein 3; Growth arrest-specific protein 2-like 3", "protein_names_refseq": "GAS2-like protein 3 isoform 1; GAS2-like protein 3; growth arrest-specific protein 2-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:237436)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;24706950;25428506;28698371", "class_list": "", "function": "Cardiomyocytes from Gas2l3-deficient mice exhibit increased expression of a p53-transcriptional program including the cell cycle inhibitor p21. Furthermore, loss of GAS2L3 results in premature binucleation of cardiomyocytes accompanied by unresolved midbody structures., [RefSeq, PubMed]; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCF5", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0009617 response to bacterium;GO:0030036 actin cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization;GO:0051764 actin crosslink formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UWW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9W6-1", "uniprot_id": "F217A_MOUSE", "mass": 46769.0, "length": 419, "protein_name": "Protein FAM217A", "gene_name": "Fam217a", "organism": "Mouse", "refseq_name": "protein FAM217A", "refseq_ac": "NP_082243", "gene_names_uniprotkb": "Fam217a; 1700026J04Rik", "gene_names_refseq": "1700026J04Rik; Fam217a", "protein_names_uniprotkb": "Protein FAM217A", "protein_names_refseq": "protein FAM217A; uncharacterized protein C6orf146 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71864)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;21750661", "class_list": "", "function": "1700026J04Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61576-1", "uniprot_id": "FKB10_MOUSE", "mass": 64697.0, "length": 581, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP10", "gene_name": "Fkbp10", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1 precursor", "refseq_ac": "NP_034351", "gene_names_uniprotkb": "Fkbp10; Fkbp-rs; Fkbp1-rs; Fkbp65; Fkbp6; Fkbprp", "gene_names_refseq": "FKBP-10; FKBP-65; FKBP65; Fkbp-rs1; Fkbp1-rs; Fkbp10; Fkbp6; Fkbprp", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP10; 5.2.1.8; 65 kDa FK506-binding protein; 65 kDa FKBP; FK506-binding protein 10; FKBP-10; FKBP-65; Immunophilin FKBP65; PPIase FKBP10; Rotamase", "protein_names_refseq": "65 kDa FK506-binding protein; 65 kDa FKBP; FK506 binding protein 6 (65 kDa); PPIase FKBP10; immunophilin FKBP65; peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1 precursor; peptidyl-prolyl cis-trans isomerase FKBP10; rotamase", "tax_id": 10090, "disease": "osteogenesis imperfecta type 11 (Disease Ontology:DOID:0110351)", "pathway": " (mmu:14230)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11071917;12036304;21750661;30899004;34161280;7493967;7507077", "class_list": "", "function": "Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta., [RefSeq, PubMed]; PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2A4I0;Q8VHI1", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005528 FK506 binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0001701 in utero embryonic development;GO:0030199 collagen fibril organization;GO:0006457 protein folding;GO:0035909 aorta morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q61576-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R059-1", "uniprot_id": "GALE_MOUSE", "mass": 38225.0, "length": 347, "protein_name": "UDP-glucose 4-epimerase", "gene_name": "Gale", "organism": "Mouse", "refseq_name": "UDP-glucose 4-epimerase", "refseq_ac": "NP_001343422", "gene_names_uniprotkb": "Gale", "gene_names_refseq": "2310002A12Rik; Gale", "protein_names_uniprotkb": "UDP-glucose 4-epimerase; 5.1.3.2; 5.1.3.7; Galactowaldenase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase", "protein_names_refseq": "UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase; UDP-glucose 4-epimerase; galactowaldenase", "tax_id": 10090, "disease": "galactose epimerase deficiency (Disease Ontology:DOID:0111458); thrombocytopenia (Disease Ontology:DOID:1588); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (mmu:74246); (R-MMU-70370)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;23257357;25605945;28877911;31219806;34428180", "class_list": "glycogene", "function": "Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids., [UniProtKB, UniProtKB]; Results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes., [RefSeq, PubMed]; These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.1.3.2;5.1.3.7", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003978 UDP-glucose 4-epimerase activity;GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0061623 glycolytic process from galactose;GO:0019388 galactose catabolic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R059-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KR8-1", "uniprot_id": "FUCO2_MOUSE", "mass": 53645.0, "length": 461, "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "Fuca2", "organism": "Mouse", "refseq_name": "plasma alpha-L-fucosidase isoform a precursor", "refseq_ac": "NP_001317127", "gene_names_uniprotkb": "Fuca2", "gene_names_refseq": "0610025O11Rik; 5530401P20Rik; Fuca2", "protein_names_uniprotkb": "Plasma alpha-L-fucosidase; 3.2.1.51; Alpha-L-fucosidase 2; Alpha-L-fucoside fucohydrolase 2", "protein_names_refseq": "alpha-L-fucoside fucohydrolase 2; plasma alpha-L-fucosidase isoform a precursor; plasma alpha-L-fucosidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66848); (R-MMU-381426); (R-MMU-6798695); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "glycogene;glycosylhydrolase", "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEM3;Q9D7Z8;Q9DCL7", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.4.24.81;3.6.4.-;3.2.1.17;5.3.4.1;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.4.21.69;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;2.7.11.1;3.4.21.76;1.16.3.1;1.11.1.9;1.16.3.4;3.5.3.1;1.6.5.5;3.5.1.26;3.4.21.-;2.4.1.145;3.1.6.14;3.1.3.16;3.1.1.3;1.8.3.2;5.3.99.3;6.3.4.21;2.4.1.1;3.1.1.98;2.3.3.8;1.8.4.-;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.21.112;3.4.19.9", "go_molecular_function": "GO:0004560 alpha-L-fucosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:0009617 response to bacterium;GO:0016139 glycoside catabolic process;GO:0006004 fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99KR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CF36-1", "uniprot_id": "F229B_MOUSE", "mass": 8765.0, "length": 80, "protein_name": "Protein FAM229B", "gene_name": "Fam229b", "organism": "Mouse", "refseq_name": "protein FAM229B isoform 1", "refseq_ac": "NP_899077", "gene_names_uniprotkb": "Fam229b; 1700025K23Rik", "gene_names_refseq": "1700025K23Rik; Fam229b", "protein_names_uniprotkb": "Protein FAM229B", "protein_names_refseq": "UPF0731 protein C6orf225 homolog; protein FAM229B isoform 1; protein FAM229B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66337)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CF36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIX9-1", "uniprot_id": "FASTK_MOUSE", "mass": 57726.0, "length": 511, "protein_name": "Fas-activated serine/threonine kinase", "gene_name": "Fastk", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fastk", "gene_names_refseq": "", "protein_names_uniprotkb": "Fas-activated serine/threonine kinase; 2.7.11.1; 2.7.11.8; FAST kinase", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "21750661;25704814;26495903;30084848;31219806;34428180", "class_list": "", "function": "Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor (By similarity). Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0003723 RNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0033867 Fas-activated serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0016607 nuclear speck;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0006468 protein phosphorylation;GO:0006915 apoptotic process;GO:0043484 regulation of RNA splicing;GO:0044528 regulation of mitochondrial mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JIX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CC14-1", "uniprot_id": "F216B_MOUSE", "mass": 15571.0, "length": 138, "protein_name": "Protein FAM216B", "gene_name": "Fam216b", "organism": "Mouse", "refseq_name": "protein FAM216B", "refseq_ac": "NP_808297", "gene_names_uniprotkb": "Fam216b; AU021034", "gene_names_refseq": "9330158N17; Fam216b", "protein_names_uniprotkb": "Protein FAM216B", "protein_names_refseq": "protein FAM216B", "tax_id": 10090, "disease": "", "pathway": " (mmu:219170)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CC14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZQ9-1", "uniprot_id": "ABITM_MOUSE", "mass": 21597.0, "length": 193, "protein_name": "Protein Abitram", "gene_name": "Abitram", "organism": "Mouse", "refseq_name": "protein Abitram", "refseq_ac": "NP_001074889", "gene_names_uniprotkb": "Abitram; Fam206a; Simiate", "gene_names_refseq": "Abitram; Fam206a; simiate", "protein_names_uniprotkb": "Protein Abitram; Actin-binding transcription modulator; Protein Simiate", "protein_names_refseq": "family with sequence similarity 206, member A; protein Abitram; protein FAM206A; protein Simiate", "tax_id": 10090, "disease": "", "pathway": " (mmu:230234)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;24349419;24782708;35787638", "class_list": "", "function": "Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons., [UniProtKB, PubMed]; Simiate and the focal adhesion kinase FAK1 cooperate in the regulation of dendritogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWF9", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0030027 lamellipodium;GO:0030425 dendrite;GO:0030426 growth cone", "go_biological_process": "GO:0048813 dendrite morphogenesis;GO:0051489 regulation of filopodium assembly;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80ZQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE08-1", "uniprot_id": "FBX33_MOUSE", "mass": 63363.0, "length": 562, "protein_name": "F-box only protein 33", "gene_name": "Fbxo33", "organism": "Mouse", "refseq_name": "F-box only protein 33", "refseq_ac": "NP_001028328", "gene_names_uniprotkb": "Fbxo33", "gene_names_refseq": "5730501N20Rik; Fbxo33", "protein_names_uniprotkb": "F-box only protein 33; AIG30-12-1", "protein_names_refseq": "AIG30-12-1; F-box only protein 33", "tax_id": 10090, "disease": "", "pathway": " (mmu:70611)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15380003;16797541;21750661;22872234;33649389;34203471;34428180;35820727", "class_list": "", "function": "FBX33 as a component of an SCF E3-ubiquitin ligase that targets the multifunctional regulator Y-box binding protein 1 (YB-1)/dbpB/p50 for polyubiquitination and destruction by the proteasome., [RefSeq, PubMed]; MRNA expression in the hippocampus 1 h following generalized convulsive seizure, in a pattern which is typical for other activity-dependant genes expressed in this structure., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JLR4;E9QMJ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VE08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMJ2-1", "uniprot_id": "FBXW4_MOUSE", "mass": 46142.0, "length": 410, "protein_name": "F-box/WD repeat-containing protein 4", "gene_name": "Fbxw4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fbxw4; Fbw4", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 4; F-box and WD-40 domain-containing protein 4; Protein hagoromo", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:30838); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10531037;10801422;21750661;29153991", "class_list": "", "function": "Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXW3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0060173 limb development;GO:0042733 embryonic digit morphogenesis;GO:0051216 cartilage development;GO:0002053 positive regulation of mesenchymal cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JMJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJY2-1", "uniprot_id": "G2E3_MOUSE", "mass": 81784.0, "length": 716, "protein_name": "G2/M phase-specific E3 ubiquitin-protein ligase", "gene_name": "G2e3", "organism": "Mouse", "refseq_name": "G2/M phase-specific E3 ubiquitin-protein ligase isoform 1", "refseq_ac": "NP_001015099", "gene_names_uniprotkb": "G2e3; Kiaa1333", "gene_names_refseq": "6030408C04Rik; 9030416F18; D930034K21Rik; G2e3; mKIAA1333", "protein_names_uniprotkb": "G2/M phase-specific E3 ubiquitin-protein ligase; 2.3.2.26; G2/M phase-specific HECT-type E3 ubiquitin transferase", "protein_names_refseq": "G2/M phase-specific E3 ubiquitin-protein ligase isoform 1; G2/M phase-specific E3 ubiquitin-protein ligase; G2/M phase-specific HECT-type E3 ubiquitin transferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:217558)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18511420;21750661;25428506;30084848;30779550;34203471", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in the establishment of constitutive heterochromatin at pericentric regions by catalyzing histone H3 'Lys-14' monoubiquitination (H3K14ub). H3K14ub represents a specific tag for heterochromatin formation by facilitating the deposition of histone H3 trimethylated at 'Lys-9' (H3K9me3). Highly expressed in G2/M phase and associates with mitotic chromosomes in an RNA-dependent manner to catalyze H3K14ub, thereby promoting recruitment of SUV39H (SUV39H1 and/or SUV39H2) and subsequent recruitment of HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones., [UniProtKB, UniProtKB]; G2E3 is a dual function ubiquitin ligase essential for prevention of apoptosis in early embryogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QK24;Q6ZPT7;Q8BNA4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0140851 histone H3K14 ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006915 apoptotic process;GO:0000209 protein polyubiquitination;GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;GO:0034502 protein localization to chromosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5RJY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZU9-1", "uniprot_id": "G137A_MOUSE", "mass": 43574.0, "length": 396, "protein_name": "Integral membrane protein GPR137", "gene_name": "Gpr137", "organism": "Mouse", "refseq_name": "integral membrane protein GPR137 isoform 2", "refseq_ac": "NP_001170831", "gene_names_uniprotkb": "Gpr137; Tm7sf1l1", "gene_names_refseq": "Gpr137", "protein_names_uniprotkb": "Integral membrane protein GPR137; Transmembrane 7 superfamily member 1-like 1 protein", "protein_names_refseq": "G protein-coupled receptor TM7SF1L1; integral membrane protein GPR137 isoform 2; integral membrane protein GPR137; transmembrane 7 superfamily member 1-like 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:107173)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12679517;21750661;28975893;31219806;36436172;38163861", "class_list": "", "function": "GPR137 Inhibits Cell Proliferation and Promotes Neuronal Differentiation in the Neuro2a Cells., [RefSeq, PubMed]; GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy., [UniProtKB, UniProtKB]; May activate Wnt/beta-catenin signaling to modulate epithelial cell function., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UB6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010506 regulation of autophagy;GO:0006914 autophagy;GO:0045671 negative regulation of osteoclast differentiation;GO:0045779 negative regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80ZU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SSG4-1", "uniprot_id": "GA2L2_MOUSE", "mass": 94318.0, "length": 860, "protein_name": "GAS2-like protein 2", "gene_name": "Gas2l2", "organism": "Mouse", "refseq_name": "GAS2-like protein 2", "refseq_ac": "NP_001013781", "gene_names_uniprotkb": "Gas2l2", "gene_names_refseq": "Gas2l2", "protein_names_uniprotkb": "GAS2-like protein 2; Growth arrest-specific protein 2-like 2", "protein_names_refseq": "GAS2-like protein 2", "tax_id": 10090, "disease": "primary ciliary dyskinesia 41 (Disease Ontology:DOID:0111858); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:237891)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23994616;24706950;30665704;31219806", "class_list": "", "function": "G2L2 is a new effector that controls the action of A2AR by modulating its ability to regulate the Galphas-mediated cAMP contents., [RefSeq, PubMed]; Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G protein complexes to ADORA2A (PubMed:23994616). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results show that a pathogenic variant in GAS2L2 causes a genetic defect in ciliary orientation and impairs mucociliary clearance and results in primary ciliary dyskinesia, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EJR3", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0008093 cytoskeletal anchor activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0001725 stress fiber;GO:0036064 ciliary basal body", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007026 negative regulation of microtubule depolymerization;GO:0051764 actin crosslink formation;GO:0060296 regulation of cilium beat frequency involved in ciliary motility", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SSG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5H8B9-1", "uniprot_id": "FREM3_MOUSE", "mass": 234999.0, "length": 2123, "protein_name": "FRAS1-related extracellular matrix protein 3", "gene_name": "Frem3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Frem3; Gm795; Nv2", "gene_names_refseq": "", "protein_names_uniprotkb": "FRAS1-related extracellular matrix protein 3; NV domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "Fraser syndrome (Disease Ontology:DOID:0090001)", "pathway": " (mmu:333315)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15345741;15878328;21750661;26495903;35820727", "class_list": "", "function": "Extracellular matrix protein which may play a role in cell adhesion., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0007154 cell communication;GO:0010669 epithelial structure maintenance;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5H8B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97324-1", "uniprot_id": "G6PD2_MOUSE", "mass": 59126.0, "length": 513, "protein_name": "Glucose-6-phosphate 1-dehydrogenase 2", "gene_name": "G6pd2", "organism": "Mouse", "refseq_name": "glucose-6-phosphate 1-dehydrogenase 2", "refseq_ac": "NP_062341", "gene_names_uniprotkb": "G6pd2; G6pd-2", "gene_names_refseq": "G6pd2; G6pdx-ps1; Gpd-2; Gpd2", "protein_names_uniprotkb": "Glucose-6-phosphate 1-dehydrogenase 2; 1.-.-.-; 1.1.1.49; G6PD", "protein_names_refseq": "G6PD; glucose-6-phosphate 1-dehydrogenase 2; glucose-6-phosphate dehydrogenase X-linked, pseudogene 1", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nonspherocytic hemolytic anemia 1 (Disease Ontology:DOID:0051003); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); malaria (Disease Ontology:DOID:12365); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); renovascular hypertension (Disease Ontology:DOID:1591); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); neonatal jaundice (Disease Ontology:DOID:2383); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); kidney disease (Disease Ontology:DOID:557); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); hyperhomocysteinemia (Disease Ontology:DOID:9279); phenylketonuria (Disease Ontology:DOID:9281); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14380)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;36565645;9169132", "class_list": "glycogene", "function": "Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 51, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 24, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB18", "ec_number_list": "1.-.-.-;1.1.1.49;3.1.1.31;1.1.1.47;1.1.1.363", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding;GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0006739 NADP+ metabolic process;GO:0043249 erythrocyte maturation;GO:0045471 response to ethanol;GO:0006098 pentose-phosphate shunt", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61315-1", "uniprot_id": "G3ST3_MOUSE", "mass": 49277.0, "length": 431, "protein_name": "Galactose-3-O-sulfotransferase 3", "gene_name": "Gal3st3", "organism": "Mouse", "refseq_name": "galactose-3-O-sulfotransferase 3", "refseq_ac": "NP_001019888", "gene_names_uniprotkb": "Gal3st3", "gene_names_refseq": "Gal3st3", "protein_names_uniprotkb": "Galactose-3-O-sulfotransferase 3; 2.8.2.-; Beta-galactose-3-O-sulfotransferase 3; Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3; Gal3ST-3", "protein_names_refseq": "beta-galactose-3-O-sulfotransferase 3; gal-beta-1, 3-GalNAc 3'-sulfotransferase 3; gal3ST-3; galactose-3-O-sulfotransferase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:545276)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;30899004", "class_list": "", "function": "Catalyzes the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (PAPS) to the C-3 hydroxyl group of terminal non-reducing beta-1,4-linked galactose residues in both N-glycans and O-glycans. It acts efficiently on type 2 chains (Gal-beta-1,4-GlcNAc-R) found in N-glycans and core 2-branched O-glycans (Gal-beta-1,4-GlcNAc-beta-1,6(Gal-beta-1,3)GalNAc-R). In contrast, it shows poor activity on type 1 chains (Gal-beta-1,3-GlcNAc-R) and intermediate activity on core 1 structures (Gal-beta-1,3-GalNAc-R). Participates in the glycoconjugates sulfation namely the 3'-sulfated Lewis X epitope (Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc), by sulfating N-acetyllactosamine (Gal-beta-1,4-GlcNAc) at the 3' position; then the resulting modification is fucosylated by FUT5., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050694 galactose 3-O-sulfotransferase activity;GO:0001733 galactosylceramide sulfotransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P61315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63075-1", "uniprot_id": "FGF17_MOUSE", "mass": 24924.0, "length": 216, "protein_name": "Fibroblast growth factor 17", "gene_name": "Fgf17", "organism": "Mouse", "refseq_name": "fibroblast growth factor 17 isoform 1 precursor", "refseq_ac": "NP_032030", "gene_names_uniprotkb": "Fgf17", "gene_names_refseq": "FGF-17; Fgf17; Fgf6b", "protein_names_uniprotkb": "Fibroblast growth factor 17; FGF-17", "protein_names_refseq": "fibroblast growth factor 17 isoform 1 precursor; fibroblast growth factor 6b", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 20 with or without anosmia (Disease Ontology:DOID:0090082)", "pathway": " (mmu:14171); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190371); (R-MMU-190372); (R-MMU-190373); (R-MMU-190375); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5658623); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 32, "publication_count": 3, "publication_id_list": "35545674;9514906;9651520", "class_list": "glycogene", "function": "Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development., [UniProtKB]; The expression from early streak stage to midgestation of Fgf17 is measured. It is closely related to Fgf8 (63.7% identical at the amino acid level). Fgf17 is expressed during gastrulation but at lower levels than Fgf8., [RefSeq, PubMed]; Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17. Erratum:[Nature. 2023 Jan;613(7942):E1. doi: 10.1038/s41586-022-05630-z. PMID: 36513761], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70627", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63075-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70377-1", "uniprot_id": "FGF13_MOUSE", "mass": 27588.0, "length": 245, "protein_name": "Fibroblast growth factor 13", "gene_name": "Fgf13", "organism": "Mouse", "refseq_name": "fibroblast growth factor 13 isoform 3", "refseq_ac": "NP_001277344", "gene_names_uniprotkb": "Fgf13; Fhf2", "gene_names_refseq": "Fgf13; Fgf1c; Fhf2", "protein_names_uniprotkb": "Fibroblast growth factor 13; FGF-13; FHF-2; Fibroblast growth factor homologous factor 2", "protein_names_refseq": "fibroblast growth factor 13 isoform 3; fibroblast growth factor 1c; fibroblast growth factor homologous factor 2", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); developmental and epileptic encephalopathy 90 (Disease Ontology:DOID:0070381); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:14168)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10644718;11378392;12244047;21183079;21750661;21817159;22726441;30679375;38821375;8790420;9232594", "class_list": "glycogene", "function": "Does not seem to be involved in neuroblast polarization and migration but regulates axon branching., [UniProtKB, PubMed]; FGF13 deficiency ameliorates calcium signaling abnormality in heart failure by regulating microtubule stability., [RefSeq, PubMed]; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (PubMed:22726441). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (PubMed:22726441). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (PubMed:22726441). Regulates voltage-gated sodium channel transport and function (PubMed:21817159). May also play a role in MAPK signaling (PubMed:11378392, PubMed:12244047). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (PubMed:30679375)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AU21;O35338;Q3UR31;Q8VCY9;Q9JLA5", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0017080 sodium channel regulator activity;GO:0030295 protein kinase activator activity;GO:0044325 transmembrane transporter binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0048755 branching morphogenesis of a nerve;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P70377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97376-1", "uniprot_id": "FRG1_MOUSE", "mass": 29127.0, "length": 258, "protein_name": "Protein FRG1", "gene_name": "Frg1", "organism": "Mouse", "refseq_name": "protein FRG1", "refseq_ac": "NP_038550", "gene_names_uniprotkb": "Frg1", "gene_names_refseq": "Frg1", "protein_names_uniprotkb": "Protein FRG1; FSHD region gene 1 protein", "protein_names_refseq": "FSHD region gene 1 protein; protein FRG1", "tax_id": 10090, "disease": "facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727)", "pathway": " (mmu:14300)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "16341202;20173027;20970242;22872234;23525014;23720823;24305066;25326393;25428506;27234941;30084848;31219806;34203471;34428180;36210013;9714712", "class_list": "", "function": "Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B., [UniProtKB, PubMed]; FRG1 is involved in the morphogenesis of the tooth germ, as well as in the formation of enamel and dentin matrices and that FRG1 may play a role in the odontogenesis in the mouse following BMP4 stimulation., [RefSeq, PubMed]; Mouse Frg1 genomic area lacks DUX4 binding sites and DUX4 is unable to activate the endogenous mouse Frg1 gene providing a possible explanation for the lack of muscle phenotype in DUX4 transgenic mice., [RefSeq, PubMed]; On the basis of these results, it was proposed that aberrant fTnT represents a biological marker of muscle phenotype severity and disease progression., [RefSeq, PubMed]; This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis., [RefSeq, PubMed]; Transgenic overexpression results in a muscle-growth defect and a muscle regeneration impairment, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M42", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0030018 Z disc;GO:0015030 Cajal body;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0007517 muscle organ development;GO:0008380 RNA splicing;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97376-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00420-1", "uniprot_id": "GABP1_MOUSE", "mass": 41358.0, "length": 383, "protein_name": "GA-binding protein subunit beta-1", "gene_name": "Gabpb1", "organism": "Mouse", "refseq_name": "GA-binding protein subunit beta-1 isoform a", "refseq_ac": "NP_001258396", "gene_names_uniprotkb": "Gabpb1; Gabpb2; Gabpb", "gene_names_refseq": "BABPB2; E4TF1-47; E4TF1-53; E4TF1; E4Tf1B; GABPB-1; GABPB-2; GABPB1-1; GABPB1-2; GABPB; Gabpb1; NRF2B1; NRF2B2", "protein_names_uniprotkb": "GA-binding protein subunit beta-1; GABP subunit beta-1; GABP subunit beta-2; GABPB-1; GABPB-2", "protein_names_refseq": "GA binding protein subunit beta1; GA-binding protein subunit beta-1 isoform a; GA-binding protein subunit beta-1; GABP subunit beta-1; GABP subunit beta-2; Gabp beta1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14391); (R-MMU-2151201)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11318655;1876836;21750661;22862946;25200183;37640449;9461436", "class_list": "", "function": "Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos. Publication Status: Online-Only, [RefSeq, PubMed]; SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1., [RefSeq, PubMed]; The findings identify the tetramer-forming GABPbeta1 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy., [RefSeq, PubMed]; Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:25200183). Acts as a master regulator of nuclear-encoded mitochondrial genes (PubMed:25200183)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ68;A2AQ70;Q00421;Q8BS31;Q91YZ0;Q9QVV2", "ec_number_list": "", "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00420-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00422-1", "uniprot_id": "GABPA_MOUSE", "mass": 51344.0, "length": 454, "protein_name": "GA-binding protein alpha chain", "gene_name": "Gabpa", "organism": "Mouse", "refseq_name": "GA-binding protein alpha chain isoform 1", "refseq_ac": "NP_032091", "gene_names_uniprotkb": "Gabpa; E4tf1a", "gene_names_refseq": "GABPalpha; Gabpa", "protein_names_uniprotkb": "GA-binding protein alpha chain; GABP subunit alpha", "protein_names_refseq": "GA-binding protein alpha chain isoform 1; GA-binding protein alpha chain; GA-binding protein alpha-subunit; GABP subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:14390); (R-MMU-2151201)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11318655;1876836;25605945;34428180;36852467;38765953;40885482;40997131;9461436", "class_list": "", "function": "Epigenetically active chromatin in neonatal iWAT reveals GABPalpha as a potential regulator of beige adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor Rhit/Zpf13., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TT22", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0038127 ERBB signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q00422-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TQB2-1", "uniprot_id": "FXRD1_MOUSE", "mass": 54178.0, "length": 487, "protein_name": "FAD-dependent oxidoreductase domain-containing protein 1", "gene_name": "Foxred1", "organism": "Mouse", "refseq_name": "FAD-dependent oxidoreductase domain-containing protein 1 isoform 2", "refseq_ac": "NP_001278377", "gene_names_uniprotkb": "Foxred1", "gene_names_refseq": "Foxred1; TEG-23; Tex23", "protein_names_uniprotkb": "FAD-dependent oxidoreductase domain-containing protein 1; 1.-.-.-", "protein_names_refseq": "FAD-dependent oxidoreductase domain-containing protein 1 isoform 2; FAD-dependent oxidoreductase domain-containing protein 1; testis expressed gene 23", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 19 (Disease Ontology:DOID:0112085)", "pathway": " (mmu:235169)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;35820727", "class_list": "", "function": "Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1D0", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TQB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NBU5-1", "uniprot_id": "FBX39_MOUSE", "mass": 52554.0, "length": 443, "protein_name": "F-box only protein 39", "gene_name": "Fbxo39", "organism": "Mouse", "refseq_name": "F-box only protein 39", "refseq_ac": "NP_001093158", "gene_names_uniprotkb": "Fbxo39", "gene_names_refseq": "1700010H23Rik; Fbxo39", "protein_names_uniprotkb": "F-box only protein 39", "protein_names_refseq": "F-box only protein 39; F-box protein 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:628100)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5NBU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SRY7-1", "uniprot_id": "FBW1B_MOUSE", "mass": 62063.0, "length": 542, "protein_name": "F-box/WD repeat-containing protein 11", "gene_name": "Fbxw11", "organism": "Mouse", "refseq_name": "F-box/WD repeat-containing protein 11 isoform b", "refseq_ac": "NP_001258276", "gene_names_uniprotkb": "Fbxw11; Btrcp2; Fbw1b; Fbxw1b", "gene_names_refseq": "2310065A07Rik; BTRC2; BTRCP2; Fbxw11; Fbxw1b; HOS", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 11; F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; HOS; Homologous to Slimb protein", "protein_names_refseq": "F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 1B; F-box/WD repeat-containing protein 11 isoform b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; homologous to Slimb protein", "tax_id": 10090, "disease": "Menkes disease (Disease Ontology:DOID:1838)", "pathway": " (mmu:103583); (R-MMU-1169091); (R-MMU-202424); (R-MMU-2565942); (R-MMU-2871837); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-69601); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 12, "publication_count": 9, "publication_id_list": "11850814;11896578;15917222;18782782;21750661;30031111;30391586;33640602;38182068", "class_list": "", "function": "Beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1., [RefSeq, PubMed]; Data show that beta-TrCP2 and beta-TrCP1 target PER2 protein in vitro, and also show that the beta-TrCP binding site of PER2 is recognized by both beta-TrCP1 and beta-TrCP2 [beta-TrCP2]., [RefSeq, PubMed]; E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-kappaB pathway activation in pancreatitis and pancreatic cancer., [RefSeq, PubMed]; FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-beta plaque formation via repression of ASK1 signaling., [RefSeq, PubMed]; Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11896578). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (By similarity). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (By similarity). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (PubMed:11896578). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (By similarity). SCF(FBXW11) mediates the ubiquitination of IFNAR1 (By similarity). SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1 (By similarity). Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2 (PubMed:18782782). SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (By similarity). SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGM9;Q3TLZ8;Q8BY90;Q8K022;Q923H0", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5SRY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SSF7-1", "uniprot_id": "TET5C_MOUSE", "mass": 44797.0, "length": 391, "protein_name": "Terminal nucleotidyltransferase 5C", "gene_name": "Tent5c", "organism": "Mouse", "refseq_name": "terminal nucleotidyltransferase 5C", "refseq_ac": "NP_001136424", "gene_names_uniprotkb": "Tent5c; Fam46c", "gene_names_refseq": "4930431B09Rik; Fam46c; Tent5c", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5C; 2.7.7.19", "protein_names_refseq": "DN-384L23.3; family with sequence similarity 46, member C; protein FAM46C; putative nucleotidyltransferase FAM46C; terminal nucleotidyltransferase 5C", "tax_id": 10090, "disease": "", "pathway": " (mmu:74645)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "28931820;30084848;30779550;34048638;34428180", "class_list": "", "function": "Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:34048638). Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (By similarity). Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820)., [UniProtKB, UniProtKB, PubMed, PubMed]; FAM46C protein is strongly induced during activation of primary splenocytes and that B lymphocytes isolated from newly generated FAM46C KO mice proliferate faster than those isolated from their WT littermates. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P629;Q80XL2;Q9CUN7", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:0003723 RNA binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0048255 mRNA stabilization;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SSF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5STT6-1", "uniprot_id": "GAR3_MOUSE", "mass": 68885.0, "length": 665, "protein_name": "Golgi-associated RAB2B interactor protein 3", "gene_name": "Garin3", "organism": "Mouse", "refseq_name": "Golgi-associated RAB2B interactor protein 3", "refseq_ac": "NP_001013805", "gene_names_uniprotkb": "Garin3; Fam71b", "gene_names_refseq": "Fam71b; Gari-l3; Garin3", "protein_names_uniprotkb": "Golgi-associated RAB2B interactor protein 3; Protein FAM71B", "protein_names_refseq": "Golgi associated RAB2B interactor protein 3; Golgi-associated RAB2B interactor protein 3; Golgi-associated Rab2B interactor-like 3; family with sequence similarity 71, member B; protein FAM71B", "tax_id": 10090, "disease": "", "pathway": " (mmu:432552)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;18256213;20485683;25609838", "class_list": "", "function": "May be involved in RNA biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head;GO:0005794 Golgi apparatus;GO:0015030 Cajal body", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5STT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SUS0-1", "uniprot_id": "FBW10_MOUSE", "mass": 117691.0, "length": 1030, "protein_name": "F-box/WD repeat-containing protein 10", "gene_name": "Fbxw10", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fbxw10", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 10; F-box and WD-40 domain-containing protein 10", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:213980); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4G1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006954 inflammatory response;GO:0009611 response to wounding;GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5SUS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DIA9-1", "uniprot_id": "FBX27_MOUSE", "mass": 31633.0, "length": 280, "protein_name": "F-box only protein 27", "gene_name": "Fbxo27", "organism": "Mouse", "refseq_name": "F-box only protein 27 isoform 1", "refseq_ac": "NP_001157174", "gene_names_uniprotkb": "Fbxo27", "gene_names_refseq": "E130008B10Rik; FBG5; Fbxo27; Gm161", "protein_names_uniprotkb": "F-box only protein 27", "protein_names_refseq": "F-box only protein 27 isoform 1; F-box only protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:233040); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;18203720;21750661;37658156", "class_list": "glycogene", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides., [UniProtKB]; The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYP0;Q8BKF7", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0036503 ERAD pathway;GO:0006516 glycoprotein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6DIA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDJ6-1", "uniprot_id": "FBX42_MOUSE", "mass": 77777.0, "length": 717, "protein_name": "F-box only protein 42", "gene_name": "Fbxo42", "organism": "Mouse", "refseq_name": "F-box only protein 42", "refseq_ac": "NP_766106", "gene_names_uniprotkb": "Fbxo42", "gene_names_refseq": "6720460I06Rik; Fbxo42; mKIAA1332", "protein_names_uniprotkb": "F-box only protein 42", "protein_names_refseq": "F-box only protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:213499)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21183079;31219806", "class_list": "", "function": "Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A824;Q8CE76;Q99KY2", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PDJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPG8-1", "uniprot_id": "TAFA1_MOUSE", "mass": 14873.0, "length": 133, "protein_name": "Chemokine-like protein TAFA-1", "gene_name": "Tafa1", "organism": "Mouse", "refseq_name": "chemokine-like protein TAFA-1 precursor", "refseq_ac": "NP_877960", "gene_names_uniprotkb": "Tafa1; Fam19a1", "gene_names_refseq": "C630007B19Rik; FAM19A1 TAFA-1; Fam19a1; Tafa-1; Tafa1", "protein_names_uniprotkb": "Chemokine-like protein TAFA-1", "protein_names_refseq": "chemokine-like protein TAFA-1 precursor; chemokine-like protein TAFA-1; family with sequence similarity 19, member A1; protein FAM19A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320265)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15028294;29799787;31689372;32706374;34440636", "class_list": "", "function": "Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1. Publication Status: Online-Only, [RefSeq, PubMed]; Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism., [RefSeq, PubMed]; In male mice, FAM19A1 deficiency alters food intake patterns during the light and dark cycle. Fam19a1 KO mice are hyperactive, and locomotor hyperactivity is more pronounced in female KO mice., [RefSeq, PubMed]; Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation., [UniProtKB, PubMed]; This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSN6", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0014016 neuroblast differentiation;GO:0010469 regulation of signaling receptor activity;GO:1902692 regulation of neuroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TPG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UZ0-1", "uniprot_id": "FGD5_MOUSE", "mass": 134719.0, "length": 1219, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 5", "gene_name": "Fgd5", "organism": "Mouse", "refseq_name": "FYVE, RhoGEF and PH domain-containing protein 5", "refseq_ac": "NP_766319", "gene_names_uniprotkb": "Fgd5", "gene_names_refseq": "C330025N11Rik; Fgd5; ZFYVE23; mFLJ00274", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 5", "protein_names_refseq": "FYVE, RhoGEF and PH domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:232237); (R-MMU-9013149)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;22328776;22661514;24958848;34428180;37507081", "class_list": "", "function": "A new endothelial specific gene named FYVE, RhoGEF, and PH domain-containing 5 (FGD5) plays a crucial role in vascular pruning in a murine model. Erratum:[Circulation. 2012 Sep 18;126(12):e194], [RefSeq, PubMed]; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)., [UniProtKB]; Fgd5 identifies hematopoietic stem cells in the murine bone marrow., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHM5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80UZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XI1-1", "uniprot_id": "FBX34_MOUSE", "mass": 77138.0, "length": 695, "protein_name": "F-box only protein 34", "gene_name": "Fbxo34", "organism": "Mouse", "refseq_name": "F-box only protein 34 isoform 2", "refseq_ac": "NP_001139557", "gene_names_uniprotkb": "Fbxo34", "gene_names_refseq": "2900057B08Rik; 5830426G16Rik; Fbxo34", "protein_names_uniprotkb": "F-box only protein 34", "protein_names_refseq": "F-box only protein 34 isoform 2; F-box only protein 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:78938)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;33842473;34428180", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex promoting ubiquitination and proteasomal degradation of specific target proteins including HNRNPU (By similarity). Regulates both the G2/M transition and anaphase entry in meiotic oocytes (PubMed:33842473)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D290", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80XI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFZ8-1", "uniprot_id": "FA72A_MOUSE", "mass": 16626.0, "length": 149, "protein_name": "Protein FAM72A", "gene_name": "Fam72a", "organism": "Mouse", "refseq_name": "protein FAM72A", "refseq_ac": "NP_780591", "gene_names_uniprotkb": "Fam72a", "gene_names_refseq": "2700049P18Rik; Fam72a; P17", "protein_names_uniprotkb": "Protein FAM72A", "protein_names_refseq": "protein FAM72A", "tax_id": 10090, "disease": "", "pathway": " (mmu:108900)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21317926;34819670;34819671", "class_list": "", "function": "FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation., [RefSeq, PubMed]; Fam72a enforces error-prone DNA repair during antibody diversification., [RefSeq, PubMed]; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RR49;Q3KQN3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BFZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG21-1", "uniprot_id": "FLOWR_MOUSE", "mass": 18343.0, "length": 171, "protein_name": "Calcium channel flower homolog", "gene_name": "Cacfd1", "organism": "Mouse", "refseq_name": "calcium channel flower homolog isoform 2", "refseq_ac": "NP_001230168", "gene_names_uniprotkb": "Cacfd1; 5930434B04Rik", "gene_names_refseq": "5930434B04Rik; Cacfd1; mFwe", "protein_names_uniprotkb": "Calcium channel flower homolog; Calcium channel flower domain-containing protein 1", "protein_names_refseq": "calcium channel flower domain-containing protein 1; calcium channel flower homolog isoform 2; calcium channel flower homolog; likely ortholog of H. sapiens chromosome 9 open reading frame 7 (C9orf7)", "tax_id": 10090, "disease": "", "pathway": " (mmu:381356)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22362363;28414717;29288152", "class_list": "", "function": "Skin papilloma cells take advantage of mFwe activity to facilitate their clonal expansion., [RefSeq, PubMed]; The Flower protein mutant lacking binding sites for the endocytic adaptor AP-2 proteins fails to rescue endocytosis, indicating that Flower protein interacts with proteins of the endocytic machinery to mediate granule endocytosis. Thus, our data identify Flower protein as a key protein mediating granule endocytosis., [RefSeq, PubMed]; Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:22362363, PubMed:29288152). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules (CGs) at the immuno synapse (PubMed:29288152). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:22362363)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR22;A2AR23;A6PWX1;Q8C9W0;Q8CC30;Q9CX69", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0031982 vesicle;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BG21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHC9-1", "uniprot_id": "OFUT4_MOUSE", "mass": 55533.0, "length": 489, "protein_name": "GDP-fucose protein O-fucosyltransferase 4", "gene_name": "Pofut4", "organism": "Mouse", "refseq_name": "GDP-fucose protein O-fucosyltransferase 4 precursor", "refseq_ac": "NP_082704", "gene_names_uniprotkb": "Pofut4; Fut11", "gene_names_refseq": "3110009G03Rik; Fut11; Pofut4", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 4; 2.4.1.-; 2.4.1.221; Alpha-(1,3)-fucosyltransferase 11; Fuc-TXI; FucT-XI; Fucosyltransferase 11; Fucosyltransferase XI; Galactoside 3-L-fucosyltransferase 11", "protein_names_refseq": "GDP-fucose protein O-fucosyltransferase 4 precursor; GDP-fucose protein O-fucosyltransferase 4; alpha-(1,3)-fucosyltransferase 11; fuc-TXI; fucT-XI; fucosyltransferase XI; galactoside 3-L-fucosyltransferase 11", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:73068); (R-MMU-5173105)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11698403;12370785;30899004;36403525;37828378", "class_list": "glycogene;glycosyltransferase", "function": "Amino acid sequence and expression, [RefSeq, PubMed]; Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma., [RefSeq, PubMed]; Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. Also shows minor alpha-(1,3)-fucosyltransferase activity toward activity toward biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXS9", "ec_number_list": "2.4.1.221;2.4.1.-", "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0006491 N-glycan processing", "synthesized_glycan_count": 1641, "hit_score": 1.4, "record_id": "Q8BHC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHZ0-1", "uniprot_id": "CYRIA_MOUSE", "mass": 37343.0, "length": 323, "protein_name": "CYFIP-related Rac1 interactor A", "gene_name": "Cyria", "organism": "Mouse", "refseq_name": "CYFIP-related Rac1 interactor A", "refseq_ac": "NP_001139591", "gene_names_uniprotkb": "Cyria; D12Ertd553e; Fam49a", "gene_names_refseq": "2410157M17Rik; 9630047E15; Cyria; D12Ertd553e; Fam49a", "protein_names_uniprotkb": "CYFIP-related Rac1 interactor A", "protein_names_refseq": "CYFIP-related Rac1 interactor A; family with sequence similarity 49, member A; family with sequence similarity 49, member B; protein FAM49A", "tax_id": 10090, "disease": "", "pathway": " (mmu:76820)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;26495903;26740625;31219806;34428180", "class_list": "", "function": "May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling. May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BHZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BID8-1", "uniprot_id": "FXL14_MOUSE", "mass": 43864.0, "length": 400, "protein_name": "F-box/LRR-repeat protein 14", "gene_name": "Fbxl14", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 14", "refseq_ac": "NP_598701", "gene_names_uniprotkb": "Fbxl14; Fbl14; Ppa", "gene_names_refseq": "Fbx14l; Fbxl14", "protein_names_uniprotkb": "F-box/LRR-repeat protein 14; F-box and leucine-rich repeat protein 14", "protein_names_refseq": "F-box/LRR-repeat protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:101358); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11976951;19955572;29070679;34428180", "class_list": "", "function": "Data show that Twist1 small interfering RNA prevents hypoxia-induced Fbxl14 down-regulation and SNAIL1 stabilization., [RefSeq, PubMed]; Results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process, [RefSeq, PubMed]; Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2Q9;Q8R5H7;Q8VDT7;Q922N5", "ec_number_list": "", "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BID8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKG4-1", "uniprot_id": "FZD10_MOUSE", "mass": 65318.0, "length": 582, "protein_name": "Frizzled-10", "gene_name": "Fzd10", "organism": "Mouse", "refseq_name": "frizzled-10 precursor", "refseq_ac": "NP_780493", "gene_names_uniprotkb": "Fzd10; Fz10", "gene_names_refseq": "Fz-10; Fzd10", "protein_names_uniprotkb": "Frizzled-10; Fz-10", "protein_names_refseq": "frizzled homolog 10; frizzled-10 precursor; frizzled-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:93897)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14758554;15923619;37728849", "class_list": "", "function": "Data demonstrate that Wnt7b signals through Fzd1 and -10 and LRP5 and implicate these Wnt coreceptors in the regulation of lung airway and vascular development., [RefSeq, PubMed]; MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3beta/beta-Catenin Signaling and Induce Enteric Glial Cell Apoptosis., [RefSeq, PubMed]; Receptor for Wnt proteins (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0046330 positive regulation of JNK cascade;GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BKG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQT2-1", "uniprot_id": "DIK1C_MOUSE", "mass": 45976.0, "length": 410, "protein_name": "Divergent protein kinase domain 1C", "gene_name": "Dipk1c", "organism": "Mouse", "refseq_name": "divergent protein kinase domain 1C isoform 3", "refseq_ac": "NP_776131", "gene_names_uniprotkb": "Dipk1c; Fam69c", "gene_names_refseq": "B230399E16Rik; Dipk1c; Fam69c", "protein_names_uniprotkb": "Divergent protein kinase domain 1C; Protein FAM69C", "protein_names_refseq": "divergent protein kinase domain 1C isoform 3; family with sequence similarity 69, member C; protein FAM69C", "tax_id": 10090, "disease": "", "pathway": " (mmu:240479)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21334309;21750661;36929224", "class_list": "", "function": "FAM69C functions as a kinase for eIF2alpha and promotes stress granule assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007613 memory;GO:0050808 synapse organization;GO:0051402 neuron apoptotic process;GO:0048167 regulation of synaptic plasticity;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BQT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ52-1", "uniprot_id": "FSD2_MOUSE", "mass": 81473.0, "length": 716, "protein_name": "Fibronectin type III and SPRY domain-containing protein 2", "gene_name": "Fsd2", "organism": "Mouse", "refseq_name": "fibronectin type III and SPRY domain-containing protein 2", "refseq_ac": "NP_766492", "gene_names_uniprotkb": "Fsd2; Spryd1", "gene_names_refseq": "9830160G03Rik; Fsd2; Spryd1", "protein_names_uniprotkb": "Fibronectin type III and SPRY domain-containing protein 2; Minispryn; SPRY domain-containing protein 1", "protein_names_refseq": "SPRY domain containing 1; SPRY domain-containing protein 1; fibronectin type III and SPRY domain-containing protein 2; minispryn", "tax_id": 10090, "disease": "", "pathway": " (mmu:244091)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28740084;34203471;34428180", "class_list": "", "function": "Data identify a novel muscle-expressed TRIM-related protein minispryn, encoded by Fsd2, that has extensive sequence similarity with the C-terminus of Cmya5. They appear to have originated by a chromosomal duplication and are found within evolutionarily-conserved gene clusters on different chromosomes. Both proteins co-localize with RyR2 at the junctional sarcoplasmic reticulum of isolated cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140T8J1;E9QMV0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BZ52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCH7-1", "uniprot_id": "FOG2_MOUSE", "mass": 127692.0, "length": 1151, "protein_name": "Zinc finger protein ZFPM2", "gene_name": "Zfpm2", "organism": "Mouse", "refseq_name": "zinc finger protein ZFPM2 isoform 1", "refseq_ac": "NP_035896", "gene_names_uniprotkb": "Zfpm2; Fog2", "gene_names_refseq": "B330005D23Rik; FOG-2; FOG2; Zfpm2", "protein_names_uniprotkb": "Zinc finger protein ZFPM2; FOG-2; Friend of GATA 2; Friend of GATA protein 2; Zinc finger protein multitype 2; mFOG-2", "protein_names_refseq": "Friend of GATA 2; friend of GATA protein 2; friend of GATA-1 2; friend of GATA-2; mFOG-2; zinc finger protein ZFPM2 isoform 1; zinc finger protein ZFPM2", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); tricuspid atresia (Disease Ontology:DOID:0080169); 46,XY sex reversal 9 (Disease Ontology:DOID:0111770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:22762); (R-MMU-983231)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10329627;10330188;10801815;10888889;10892744;10999851;11382775;12223418;23836893;25428506;38189150;9927674;9927675", "class_list": "", "function": "A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network., [RefSeq, PubMed]; Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z0F2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0003192 mitral valve formation;GO:0003195 tricuspid valve formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CCH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDU4-1", "uniprot_id": "FXL13_MOUSE", "mass": 90657.0, "length": 790, "protein_name": "F-box and leucine-rich repeat protein 13", "gene_name": "Fbxl13", "organism": "Mouse", "refseq_name": "F-box and leucine-rich repeat protein 13 isoform b", "refseq_ac": "NP_796050", "gene_names_uniprotkb": "Fbxl13; Drc6", "gene_names_refseq": "4921539K22Rik; Fbxl13", "protein_names_uniprotkb": "F-box and leucine-rich repeat protein 13; Dynein regulatory complex subunit 6; F-box/LRR-repeat protein 13", "protein_names_refseq": "F-box and leucine-rich repeat protein 13 isoform b; F-box/LRR-repeat protein 13; dynein regulatory complex subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:320118); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;28630322;31961863;34428180", "class_list": "", "function": "Deletion of Fbxl13 has no observable effect on sperm function. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDE9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CDU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0E8-1", "uniprot_id": "FIBB_MOUSE", "mass": 54753.0, "length": 481, "protein_name": "Fibrinogen beta chain", "gene_name": "Fgb", "organism": "Mouse", "refseq_name": "fibrinogen beta chain preproprotein", "refseq_ac": "NP_862897", "gene_names_uniprotkb": "Fgb", "gene_names_refseq": "2510049G14Rik; Fgb", "protein_names_uniprotkb": "Fibrinogen beta chain", "protein_names_refseq": "fibrinogen beta chain preproprotein; fibrinogen, B beta polypeptide", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); thrombosis (Disease Ontology:DOID:0060903); cardiovascular system disease (Disease Ontology:DOID:1287); alcohol use disorder (Disease Ontology:DOID:1574); congenital afibrinogenemia (Disease Ontology:DOID:2236); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (mmu:110135); (R-MMU-114608); (R-MMU-216083); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-5674135); (R-MMU-5686938); (R-MMU-9769733)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;25428506;26495903;30084848;30899004;34428180;36288343;36438895;37507081;39927985", "class_list": "", "function": "Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways., [UniProtKB, UniProtKB]; MiR-877-5p Inhibits Epithelial Mesenchymal Transformation of Breast Cancer Cells by Targeting FGB. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to form fibrin clots of abnormal structure, and may play an important role in Alzheimer's disease. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZP1", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051087 protein-folding chaperone binding;GO:0005198 structural molecule activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0045087 innate immune response;GO:0051592 response to calcium ion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007160 cell-matrix adhesion;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K0E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2I9-1", "uniprot_id": "FBH1_MOUSE", "mass": 118298.0, "length": 1042, "protein_name": "F-box DNA helicase 1", "gene_name": "Fbh1", "organism": "Mouse", "refseq_name": "F-box DNA helicase 1 isoform 1", "refseq_ac": "NP_056607", "gene_names_uniprotkb": "Fbh1; Fbx18; Fbxo18", "gene_names_refseq": "Fbh1; Fbx18; Fbxo18", "protein_names_uniprotkb": "F-box DNA helicase 1; 5.6.2.4; DNA 3'-5' helicase 1; F-box only protein 18", "protein_names_refseq": "DNA 3'-5' helicase 1; F-box DNA helicase 1 isoform 1; F-box only protein 18; F-box protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:50755)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10531037;20173027;20457012;21750661;23361013;24108124;25428506;30084848;31219806;34428180;35820727", "class_list": "", "function": "3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:24108124). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (By similarity)., [UniProtKB, UniProtKB, PubMed]; FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks., [RefSeq, PubMed]; FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination., [RefSeq, PubMed]; Role of the F-box helicase 1 (Fbh1) protein during genome maintenance in mammalian cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C444;Q99KS0;Q9CTC6;Q9QZG7", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0019005 SCF ubiquitin ligase complex;GO:0000785 chromatin", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0001934 positive regulation of protein phosphorylation;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K2I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZS3-1", "uniprot_id": "FLCN_MOUSE", "mass": 64327.0, "length": 579, "protein_name": "Folliculin", "gene_name": "Flcn", "organism": "Mouse", "refseq_name": "folliculin", "refseq_ac": "NP_001258285", "gene_names_uniprotkb": "Flcn; Bhd", "gene_names_refseq": "B430214A04Rik; Bhd; FLCL; Flcn", "protein_names_uniprotkb": "Folliculin; Birt-Hogg-Dube syndrome protein homolog", "protein_names_refseq": "birt-Hogg-Dube syndrome protein homolog; folliculin", "tax_id": 10090, "disease": "nonpapillary renal cell carcinoma (Disease Ontology:DOID:0050387); Birt-Hogg-Dube syndrome (Disease Ontology:DOID:0050676); primary spontaneous pneumothorax (Disease Ontology:DOID:0080218); renal cell carcinoma (Disease Ontology:DOID:4450); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:216805); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "18182616;18974783;19144319;19843504;19850877;21183079;21750661;23582324;24908670;27913603;30595499;31219806;31272105;31599954;32612235;34428180", "class_list": "", "function": "Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. Erratum:[PLoS ONE. 2008;3(11). doi: 10.1371/annotation/0f06471c-1993-4144-b785-d58924ac0b5c], [RefSeq, PubMed]; FLCN is shown as a general tumour suppressor in the kidney., [RefSeq, PubMed]; Homozygous loss of BHD may initiate renal tumorigenesis in the mouse. The conditional BHD knockout mouse may be a useful research model for dissecting multistep kidney carcinogenesis, and rapamycin may be a potential treatment for Birt-Hogg-Dube syndrome, [RefSeq, PubMed]; Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:23582324, PubMed:27913603, PubMed:32612235). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:23582324, PubMed:27913603, PubMed:32612235). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (By similarity). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (By similarity). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:27913603, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (PubMed:30595499). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (PubMed:27913603). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (By similarity). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (By similarity). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4U8;Q3UFZ1;Q5SWZ2;Q5SX01;Q5SX02;Q8CAC0", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0005096 GTPase activator activity;GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1901874 negative regulation of post-translational protein modification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8QZS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R070-1", "uniprot_id": "G6PT2_MOUSE", "mass": 57355.0, "length": 531, "protein_name": "Glucose-6-phosphate exchanger SLC37A1", "gene_name": "Slc37a1", "organism": "Mouse", "refseq_name": "glucose-6-phosphate exchanger SLC37A1", "refseq_ac": "NP_001229356", "gene_names_uniprotkb": "Slc37a1", "gene_names_refseq": "G3PP; Slc37a1", "protein_names_uniprotkb": "Glucose-6-phosphate exchanger SLC37A1; Solute carrier family 37 member 1", "protein_names_refseq": "glucose-6-phosphate exchanger SLC37A1; glycerol-3-phosphate transporter; solute carrier family 37 member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224674); (R-MMU-70263)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPC2", "ec_number_list": "", "go_molecular_function": "GO:0061513 glucose 6-phosphate:phosphate antiporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0015760 glucose-6-phosphate transport;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R070-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R507-1", "uniprot_id": "FKTN_MOUSE", "mass": 53579.0, "length": 461, "protein_name": "Ribitol-5-phosphate transferase FKTN", "gene_name": "Fktn", "organism": "Mouse", "refseq_name": "ribitol-5-phosphate transferase FKTN isoform 1", "refseq_ac": "NP_647470", "gene_names_uniprotkb": "Fktn; Fcmd", "gene_names_refseq": "D830030O17Rik; Fcmd; Fktn", "protein_names_uniprotkb": "Ribitol-5-phosphate transferase FKTN; 2.7.8.-; Fukutin; Fukuyama-type congenital muscular dystrophy protein; Ribitol-5-phosphate transferase", "protein_names_refseq": "Fukuyama type congenital muscular dystrophy (fukutin); Fukuyama type congenital muscular dystrophy homolog; fukuyama-type congenital muscular dystrophy protein; ribitol-5-phosphate transferase FKTN isoform 1; ribitol-5-phosphate transferase FKTN; ribitol-5-phosphate transferase", "tax_id": 10090, "disease": "Fukuyama congenital muscular dystrophy (Disease Ontology:DOID:0050559); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); autosomal recessive limb-girdle muscular dystrophy type 2L (Disease Ontology:DOID:0110284); autosomal recessive limb-girdle muscular dystrophy type 2M (Disease Ontology:DOID:0110296); dilated cardiomyopathy 1B (Disease Ontology:DOID:0110443); dilated cardiomyopathy 1X (Disease Ontology:DOID:0110444); muscular dystrophy-dystroglycanopathy type B4 (Disease Ontology:DOID:0112379); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:246179); (R-MMU-9939291)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12408965;12467726;12471058;12670716;19017726;21750661;22872234;22922256;29416295;31219806;31848331;32833332;34428180", "class_list": "glycogene", "function": "Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:12471058). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (By similarity). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:19017726). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:19017726, PubMed:22922256). Could be involved in brain development (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Fukuyama-type congenital muscular dystrophy (FCMD) murine ortholog, Fcmd is 90% identical to that of its human counterpart, [RefSeq, PubMed]; Merosin-deficient congenital muscular dystrophy with mental retardation and cerebellar cysts, unlinked to the FCMD locus, in three Tunisian patients, [RefSeq, PubMed]; Mitochondrial dysfunction in skeletal muscle of fukutin-deficient mice is resistant to exercise- and 5-aminoimidazole-4-carboxamide ribonucleotide-induced rescue., [RefSeq, PubMed]; Study shows molecular pathogenesis of muscular dystrophy-associated cardiomyopathy in mice lacking the Fktn gene. Although cardiac Fktn elimination markedly reduced alpha-dystroglycan glycosylation and dystrophin-glycoprotein complex proteins in sarcolemma at all developmental stages, cardiac dysfunction was observed only in later adulthood, suggesting that membrane fragility is not the sole etiology of cardiac dysfunc... Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD64", "ec_number_list": "2.4.2.-;2.7.8.-;2.4.2.61;2.4.1.-", "go_molecular_function": "GO:0016780 phosphotransferase activity, for other substituted phosphate groups", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0001764 neuron migration;GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V79-1", "uniprot_id": "FITM1_MOUSE", "mass": 32280.0, "length": 292, "protein_name": "Fat storage-inducing transmembrane protein 1", "gene_name": "Fitm1", "organism": "Mouse", "refseq_name": "fat storage-inducing transmembrane protein 1", "refseq_ac": "NP_081084", "gene_names_uniprotkb": "Fitm1; Fit1", "gene_names_refseq": "1110028A07Rik; Cg10671; Fit1; Fitm1", "protein_names_uniprotkb": "Fat storage-inducing transmembrane protein 1; Fat-inducing protein 1", "protein_names_refseq": "fat storage-inducing transmembrane protein 1; fat-inducing protein 1; fat-inducing transcript 1", "tax_id": 10090, "disease": "Siddiqi syndrome (Disease Ontology:DOID:0081273); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (mmu:68680); (R-MMU-8964572)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11345588;18160536;22106267;30923760", "class_list": "", "function": "FIT1 and FIT2 are endoplasmic reticulum resident membrane proteins that induce lipid droplet accumulation in cell culture and when expressed in mouse liver., [RefSeq, PubMed]; Findings indicate that lipid droplet (LD)produced by storage-inducing transmembrane proteins 2 (FIT2) were approximately 80% larger than storage-inducing transmembrane proteins 1 (FIT1)., [RefSeq, PubMed]; Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity) (PubMed:18160536, PubMed:22106267). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity) (PubMed:22106267)., [UniProtKB, PubMed, HAMAP, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZL0;Q8CI63;Q9CTD0", "ec_number_list": "", "go_molecular_function": "GO:0017129 triglyceride binding;GO:0019992 diacylglycerol binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0019915 lipid storage;GO:0034389 lipid droplet organization;GO:0008654 phospholipid biosynthetic process;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91V79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922G2-1", "uniprot_id": "FA76A_MOUSE", "mass": 35095.0, "length": 307, "protein_name": "Protein FAM76A", "gene_name": "Fam76a", "organism": "Mouse", "refseq_name": "protein FAM76A isoform B", "refseq_ac": "NP_001157264", "gene_names_uniprotkb": "Fam76a", "gene_names_refseq": "Fam76a", "protein_names_uniprotkb": "Protein FAM76A", "protein_names_refseq": "protein FAM76A isoform B; protein FAM76A", "tax_id": 10090, "disease": "", "pathway": " (mmu:230789)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADS2;Q3U3U8;Q3V3N2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q922G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LJ1-1", "uniprot_id": "FUCO_MOUSE", "mass": 52281.0, "length": 452, "protein_name": "Tissue alpha-L-fucosidase", "gene_name": "Fuca1", "organism": "Mouse", "refseq_name": "tissue alpha-L-fucosidase precursor", "refseq_ac": "NP_077205", "gene_names_uniprotkb": "Fuca1; Fuca", "gene_names_refseq": "0610006A03Rik; 9530055J05Rik; Afuc; Fuca1; Fuca", "protein_names_uniprotkb": "Tissue alpha-L-fucosidase; 3.2.1.51; Alpha-L-fucosidase 1; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1", "protein_names_refseq": "alpha-L-fucosidase 1; alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; tissue alpha-L-fucosidase precursor; tissue alpha-L-fucosidase", "tax_id": 10090, "disease": "fucosidosis (Disease Ontology:DOID:14500); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:71665); (R-MMU-6798695); (R-MMU-975578)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "26495903;26740625;28011936;31219806;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AV51;Q3UAH8;Q8BN13;Q9DD22", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0004560 alpha-L-fucosidase activity;GO:0015928 fucosidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016139 glycoside catabolic process;GO:0006004 fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99LJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99ML4-1", "uniprot_id": "DIK1B_MOUSE", "mass": 48792.0, "length": 431, "protein_name": "Divergent protein kinase domain 1B", "gene_name": "Dipk1b", "organism": "Mouse", "refseq_name": "divergent protein kinase domain 1B", "refseq_ac": "NP_062807", "gene_names_uniprotkb": "Dipk1b; Fam69b; Pip49", "gene_names_refseq": "B230317C12Rik; Dipk1b; Fam69b; PIP49", "protein_names_uniprotkb": "Divergent protein kinase domain 1B; Pancreatitis-induced protein 49; Protein FAM69B", "protein_names_refseq": "divergent protein kinase domain 1B; family with sequence similarity 69, member B; pancreatitis-induced protein 49; protein FAM69B", "tax_id": 10090, "disease": "", "pathway": " (mmu:56279)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10679242;11281735;21334309", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VG43;Q80UM6;Q9JMG0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99ML4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPU7-1", "uniprot_id": "FBX32_MOUSE", "mass": 41504.0, "length": 355, "protein_name": "F-box only protein 32", "gene_name": "Fbxo32", "organism": "Mouse", "refseq_name": "F-box only protein 32", "refseq_ac": "NP_080622", "gene_names_uniprotkb": "Fbxo32", "gene_names_refseq": "4833442G10Rik; ATROGIN1; Fbxo32; Gm20361; MAFbx", "protein_names_uniprotkb": "F-box only protein 32; Atrogin-1; MAFbx; Muscle atrophy F-box protein", "protein_names_refseq": "F-box only protein 32; atrogin 1; muscle atrophy F-box protein", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); primary pulmonary hypertension (Disease Ontology:DOID:14557); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:67731); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11717410;24789905;34428180;38336298;39986490", "class_list": "", "function": "ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-kappaB signaling pathway., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. Negatively regulates macrophage efferocytosis by promoting the ubiquitination of the transcription factor KLF4, suppressing the receptor tyrosine kinase MERTK transcription (PubMed:39986490). Regulates LPS-induced apoptosis and mitochondrial dysfunction through ANXA1 ubiquitination and degradation (PubMed:24789905). Mediates cyclin D1 protein stabilization via 'Lys-27'-linked ubiquitination (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0071549 cellular response to dexamethasone stimulus;GO:0016567 protein ubiquitination;GO:0014894 response to denervation involved in regulation of muscle adaptation;GO:0010666 positive regulation of cardiac muscle cell apoptotic process;GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CPU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ24-1", "uniprot_id": "FBX36_MOUSE", "mass": 22075.0, "length": 188, "protein_name": "F-box only protein 36", "gene_name": "Fbxo36", "organism": "Mouse", "refseq_name": "F-box only protein 36", "refseq_ac": "NP_079662", "gene_names_uniprotkb": "Fbxo36", "gene_names_refseq": "0610008D19Rik; 1110020F21Rik; 2410002G19Rik; D1Ertd757e; Fbxo36", "protein_names_uniprotkb": "F-box only protein 36", "protein_names_refseq": "F-box only protein 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:66153)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQ24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZV8-1", "uniprot_id": "FXL20_MOUSE", "mass": 48396.0, "length": 436, "protein_name": "F-box/LRR-repeat protein 20", "gene_name": "Fbxl20", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 20", "refseq_ac": "NP_082425", "gene_names_uniprotkb": "Fbxl20; Fbl2", "gene_names_refseq": "2610511F20Rik; 4632423N09Rik; Fbl2; Fbxl20; Scr; mKIAA4147", "protein_names_uniprotkb": "F-box/LRR-repeat protein 20; F-box and leucine-rich repeat protein 20; F-box/LRR-repeat protein 2-like", "protein_names_refseq": "F-box/LRR-repeat protein 20; scrapper", "tax_id": 10090, "disease": "", "pathway": " (mmu:72194); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17803915;19144319;21183079;21750661;23316391;28292828;32366828", "class_list": "", "function": "Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain. Publication Status: Online-Only, [RefSeq, PubMed]; SCRAPPER is synapse localized E3 ubiquitin ligase which binds/ubiquinates RIM1 to regulate synaptic transmission. Erratum:[Cell. 2007 Oct 5;131(1):190], [RefSeq, PubMed]; SCRAPPER plays a critical role in the anterior cingulate cortex pre-long term potentiation as well as synaptic transmission., [RefSeq, PubMed]; SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Isoform 3 regulates neural transmission by binding and ubiquitinating RIMS1, a modulator of presynaptic plasticity., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7YE80;Q3UMN2;Q571F7;Q8BZ95", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0019005 SCF ubiquitin ligase complex;GO:0098793 presynapse", "go_biological_process": "GO:0001662 behavioral fear response;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099575 regulation of protein catabolic process at presynapse, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CZV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D164-1", "uniprot_id": "FXYD6_MOUSE", "mass": 10374.0, "length": 94, "protein_name": "FXYD domain-containing ion transport regulator 6", "gene_name": "Fxyd6", "organism": "Mouse", "refseq_name": "FXYD domain-containing ion transport regulator 6 precursor", "refseq_ac": "NP_071287", "gene_names_uniprotkb": "Fxyd6; Plp", "gene_names_refseq": "0610030I18Rik; Fxyd6; Php", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 6; PLM-like protein; Phosphohippolin", "protein_names_refseq": "FXYD domain-containing ion transport regulator 6 precursor; PLM-like protein; phosphohippolin", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:59095); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17209044;34428180", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for intracellular Na(+) with no change in the apparent affinity for extracellular K(+) (By similarity). In addition to modulating NKA kinetics, may also function as a regulator of NKA localization to the plasma membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; FXYD6 is a novel regulator of Na,K-ATPase expressed in the inner ear., [RefSeq, PubMed]; This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99NC3;Q9CXD0", "ec_number_list": "", "go_molecular_function": "GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D518-1", "uniprot_id": "F227B_MOUSE", "mass": 62785.0, "length": 532, "protein_name": "Protein FAM227B", "gene_name": "Fam227b", "organism": "Mouse", "refseq_name": "protein FAM227B", "refseq_ac": "NP_083731", "gene_names_uniprotkb": "Fam227b", "gene_names_refseq": "4930525F21Rik; Fam227b", "protein_names_uniprotkb": "Protein FAM227B", "protein_names_refseq": "protein FAM227B", "tax_id": 10090, "disease": "", "pathway": " (mmu:75823)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR82", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D518-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC63-1", "uniprot_id": "FBX3_MOUSE", "mass": 55227.0, "length": 480, "protein_name": "F-box only protein 3", "gene_name": "Fbxo3", "organism": "Mouse", "refseq_name": "F-box only protein 3 isoform 2", "refseq_ac": "NP_065618", "gene_names_uniprotkb": "Fbxo3; Fba; Fbx3", "gene_names_refseq": "1200002G09Rik; 1700026K02Rik; Fba; Fbxo3", "protein_names_uniprotkb": "F-box only protein 3", "protein_names_refseq": "F-box only protein 3 isoform 2; F-box only protein 3; F-box protein FBA", "tax_id": 10090, "disease": "", "pathway": " (mmu:57443)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10945468;21750661;23542741;25605945;27365398;36362432;38134227", "class_list": "", "function": "AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity., [RefSeq, PubMed]; E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (By similarity). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (By similarity). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2: specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (PubMed:23542741)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BHN5;A2BHN7;Q3TKB0;Q3U9C1;Q8C7I0;Q8CEJ0;Q91VI9;Q9D2J5;Q9JIE4", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0016567 protein ubiquitination;GO:0006366 transcription by RNA polymerase II;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DC63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPC2-1", "uniprot_id": "FGF23_MOUSE", "mass": 27758.0, "length": 251, "protein_name": "Fibroblast growth factor 23", "gene_name": "Fgf23", "organism": "Mouse", "refseq_name": "fibroblast growth factor 23 precursor", "refseq_ac": "NP_073148", "gene_names_uniprotkb": "Fgf23", "gene_names_refseq": "Fgf23; Fgf8b", "protein_names_uniprotkb": "Fibroblast growth factor 23; FGF-23", "protein_names_refseq": "FGF-23; fibroblast growth factor 23 precursor; fibroblast growth factor 8b", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); autosomal dominant hypophosphatemic rickets (Disease Ontology:DOID:0050948); uremia (Disease Ontology:DOID:4676); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:64654); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190372); (R-MMU-190373); (R-MMU-190374); (R-MMU-190375); (R-MMU-381426); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5658623); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-8957275)", "pathway_count": 34, "publication_count": 6, "publication_id_list": "11032749;11062477;17086194;26273529;38530370;38726894", "class_list": "glycogene", "function": "Galpha11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia. Publication Status: Online-Only, [RefSeq, PubMed]; Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Up-regulates EGR1 expression in the presence of KL (PubMed:17086194)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes Cardiac Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth Factor 23) in Mice., [RefSeq, PubMed]; This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0042369 vitamin D catabolic process;GO:0010966 regulation of phosphate transport;GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1904383 response to sodium phosphate;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EPC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQD0-1", "uniprot_id": "FZD5_MOUSE", "mass": 64138.0, "length": 585, "protein_name": "Frizzled-5", "gene_name": "Fzd5", "organism": "Mouse", "refseq_name": "frizzled-5 precursor", "refseq_ac": "NP_001036124", "gene_names_uniprotkb": "Fzd5", "gene_names_refseq": "5330434N09Rik; Fz-5; Fz5; Fzd5; mFz5", "protein_names_uniprotkb": "Frizzled-5; Fz-5; mFz5", "protein_names_refseq": "frizzled homolog 5; frizzled-5 precursor; frizzled-5", "tax_id": 10090, "disease": "coloboma (Disease Ontology:DOID:12270)", "pathway": " (mmu:14367); (R-MMU-4086398); (R-MMU-4608870); (R-MMU-4641262); (R-MMU-4641263); (R-MMU-5140745)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "11092808;11520064;18230341;20530549;34428180;8626800", "class_list": "", "function": "Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341). In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (PubMed:11092808). In neurons, activation by WNT7A promotes formation of synapses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed:11092808). Plays a role in ocular development (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G5E8F0;O08975;Q8BMR2;Q8CHK9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0019901 protein kinase binding;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0060718 chorionic trophoblast cell differentiation;GO:0099054 presynapse assembly;GO:0001525 angiogenesis;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EQD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESL8-1", "uniprot_id": "FGF16_MOUSE", "mass": 23778.0, "length": 207, "protein_name": "Fibroblast growth factor 16", "gene_name": "Fgf16", "organism": "Mouse", "refseq_name": "fibroblast growth factor 16", "refseq_ac": "NP_085117", "gene_names_uniprotkb": "Fgf16", "gene_names_refseq": "Fgf16; Fgf4c", "protein_names_uniprotkb": "Fibroblast growth factor 16; FGF-16", "protein_names_refseq": "FGF-16; fibroblast growth factor 16; fibroblast growth factor 4c", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); syndactyly type 8 (Disease Ontology:DOID:0111813)", "pathway": " (mmu:80903); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190372); (R-MMU-190375); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 23, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12619867;36399125", "class_list": "glycogene", "function": "Cloning of the adult mouse FGF-16 cDNA, [RefSeq, PubMed]; Mettl3-mediated m[6]A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTU5;Q9ERQ5", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESS2-1", "uniprot_id": "FGF22_MOUSE", "mass": 18927.0, "length": 162, "protein_name": "Fibroblast growth factor 22", "gene_name": "Fgf22", "organism": "Mouse", "refseq_name": "fibroblast growth factor 22 isoform 1 precursor", "refseq_ac": "NP_075793", "gene_names_uniprotkb": "Fgf22", "gene_names_refseq": "2210414E06Rik; FGF-22; Fgf22; Fgf5d", "protein_names_uniprotkb": "Fibroblast growth factor 22; FGF-22", "protein_names_refseq": "fibroblast growth factor 22 isoform 1 precursor; fibroblast growth factor 5d", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (mmu:67112); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190370); (R-MMU-190377); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5658623); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 19, "publication_count": 5, "publication_id_list": "11342227;12837279;15260994;21750661;34314389", "class_list": "glycogene", "function": "Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1. Publication Status: Online-Only, [RefSeq, PubMed]; FGF22 is expressed by cerebellar granule cells during the period when they receive synapses. Its receptor, FGFR2, is expressed by pontine neurons when they are making synapses on granule cells., [RefSeq, PubMed]; Fgf22 has a potential role in cutaneous development and repair., [RefSeq, PubMed]; Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis;GO:0090128 regulation of synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ28-1", "uniprot_id": "FLII_MOUSE", "mass": 144803.0, "length": 1271, "protein_name": "Protein flightless-1 homolog", "gene_name": "Flii", "organism": "Mouse", "refseq_name": "protein flightless-1 homolog isoform 1", "refseq_ac": "NP_071292", "gene_names_uniprotkb": "Flii; Fli1; Fliih", "gene_names_refseq": "3632430F08Rik; Fliih; Flii", "protein_names_uniprotkb": "Protein flightless-1 homolog", "protein_names_refseq": "cytoskeletal actin-modulating protein; flightless I homolog; protein flightless-1 homolog isoform 1; protein flightless-1 homolog", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14248)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10902907;10947868;11171324;11971982;14966289;18250455;20173027;21430700;22581781;22645316;23525008;25428506;25605945;29898994;30084848;30779550;31599954;33649389;34428180;34887587;35820727;37126682;37172723;37828378;39627609", "class_list": "", "function": "Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (PubMed:22581781, PubMed:37126682). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (PubMed:11971982, PubMed:21430700, PubMed:22581781). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Performs an essential function in early embryonic development, [RefSeq, PubMed]; Stress-induced pseudokinase TRB3 augments IL1beta signaling by interacting with Flightless homolog 1., [RefSeq, PubMed]; This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K095;Q8VI44", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005903 brush border;GO:0005925 focal adhesion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q9JJ28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJN1-1", "uniprot_id": "FGF21_MOUSE", "mass": 23237.0, "length": 210, "protein_name": "Fibroblast growth factor 21", "gene_name": "Fgf21", "organism": "Mouse", "refseq_name": "fibroblast growth factor 21 precursor", "refseq_ac": "NP_064397", "gene_names_uniprotkb": "Fgf21", "gene_names_refseq": "Fgf21; Fgf8c", "protein_names_uniprotkb": "Fibroblast growth factor 21; FGF-21", "protein_names_refseq": "fibroblast growth factor 21 precursor; fibroblast growth factor 8c", "tax_id": 10090, "disease": "atherosclerosis (Disease Ontology:DOID:1936); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:56636); (R-MMU-189200)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10858549;15902306;30605666", "class_list": "glycogene", "function": "Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010898 positive regulation of triglyceride catabolic process;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL26-1", "uniprot_id": "FMNL1_MOUSE", "mass": 122060.0, "length": 1094, "protein_name": "Formin-like protein 1", "gene_name": "Fmnl1", "organism": "Mouse", "refseq_name": "formin-like protein 1 isoform 2", "refseq_ac": "NP_001071166", "gene_names_uniprotkb": "Fmnl1; Frl1; Frl", "gene_names_refseq": "8030453N10Rik; Fmnl1; Fmnl; Fnrl; Frls", "protein_names_uniprotkb": "Formin-like protein 1; Formin-related protein", "protein_names_refseq": "formin-like protein 1 isoform 2; formin-like protein 1; formin-related gene in leukocytes; formin-related protein; lymphocyte specific formin related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:57778); (R-MMU-5663220); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10958683;16480715;16556604;18250455;18299400;19144319;19224205;20173027;21148482;21183079;21750661;21952136;25605945;26495903;26740625;28361956;30084848;30779550;31219806;32510333;34428180;35820727;39627609", "class_list": "", "function": "Binding to interphase microtubules through exon-2-encoded domain of Fmn1 provides a novel mechanism by which Fmn1 isoform Ib could coordinate actin filaments and microtubules., [RefSeq, PubMed]; FMNL1 is required for actin assembly on lipid droplets (LDs) in vitro and for NMIIa recruitment to LDs in cells. We propose a novel acto-myosin structure regulating lipid storage: FMNL1-dependent assembly of myosin II-functionalized actin filaments on LDs facilitates their dissociation, thereby affecting LD surface-to-volume ratio and enzyme accessibility to triglycerides. Publication Status: Online-Only, [RefSeq, PubMed]; Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in actin cytoskeleton dynamics and regulation of cell shape (PubMed:10958683, PubMed:21148482)., [UniProtKB, PubMed, PubMed]; The bundling activities of FRL1 and mDia2, while producing phenotypically similar bundles, differ in mechanistic detail, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAN4;Q9Z2V7", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0032794 GTPase activating protein binding;GO:0005522 profilin binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0016477 cell migration;GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization;GO:0006929 substrate-dependent cell migration;GO:0051014 actin filament severing", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9JL26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZM8-1", "uniprot_id": "FBX17_MOUSE", "mass": 32500.0, "length": 286, "protein_name": "F-box only protein 17", "gene_name": "Fbxo17", "organism": "Mouse", "refseq_name": "F-box only protein 17 isoform 2", "refseq_ac": "NP_001297616", "gene_names_uniprotkb": "Fbxo17; Fbx17; Fbxo26", "gene_names_refseq": "Fbg4; Fbx17; Fbxo17; Fbxo26", "protein_names_uniprotkb": "F-box only protein 17; F-box only protein 26", "protein_names_refseq": "F-box only protein 17 isoform 2; F-box only protein 17; F-box only protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:50760); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10531037;18203720;28298444", "class_list": "glycogene", "function": "Identified FBXO17 as an F-box protein subunit that recognizes and mediates GSK3beta polyubiquitination., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0036503 ERAD pathway;GO:0006516 glycoprotein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU81-1", "uniprot_id": "G6PT3_MOUSE", "mass": 55073.0, "length": 501, "protein_name": "Glucose-6-phosphate exchanger SLC37A2", "gene_name": "Slc37a2", "organism": "Mouse", "refseq_name": "glucose-6-phosphate exchanger SLC37A2 isoform 1", "refseq_ac": "NP_001139432", "gene_names_uniprotkb": "Slc37a2; Ci2", "gene_names_refseq": "G3PP; Slc37a1; Slc37a2; cI-2; ci2", "protein_names_uniprotkb": "Glucose-6-phosphate exchanger SLC37A2; Solute carrier family 37 member 2; cAMP-inducible protein 2", "protein_names_refseq": "cAMP inducible 2 protein; cAMP inducible gene 2; cAMP-inducible protein 2; glucose-6-phosphate exchanger SLC37A2 isoform 1; glucose-6-phosphate exchanger SLC37A2; solute carrier family 37 (glycerol-3-phosphate transporter), member 1; solute carrier family 37 member 2; sugar phosphate exchanger 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56857); (R-MMU-70263)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11004510;17356011;19144319;34428180;36170813", "class_list": "", "function": "Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels., [UniProtKB, UniProtKB]; Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter., [RefSeq, PubMed]; The function of this macrophage-specific putative sugar transporter is central to the metabolism of the macrophage population specifically present in obese white adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q571N8;Q6P4P0;Q8BV90;Q8C144;Q8R1Y0", "ec_number_list": "", "go_molecular_function": "GO:0015169 glycerol-3-phosphate transmembrane transporter activity;GO:0061513 glucose 6-phosphate:phosphate antiporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015794 glycerol-3-phosphate transmembrane transport;GO:0006127 glycerol-3-phosphate shuttle;GO:0006072 glycerol-3-phosphate metabolic process;GO:0015760 glucose-6-phosphate transport;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WU81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z186-1", "uniprot_id": "G6PC2_MOUSE", "mass": 40681.0, "length": 355, "protein_name": "Glucose-6-phosphatase 2", "gene_name": "G6pc2", "organism": "Mouse", "refseq_name": "glucose-6-phosphatase 2 isoform 2", "refseq_ac": "NP_001276785", "gene_names_uniprotkb": "G6pc2; Igrp", "gene_names_refseq": "G6pc-rs; G6pc2; IGRP", "protein_names_uniprotkb": "Glucose-6-phosphatase 2; 3.1.3.9; G-6-Pase 2; G6Pase 2; Islet-specific glucose-6-phosphatase catalytic subunit-related protein", "protein_names_refseq": "G-6-Pase 2; glucose-6-phosphatase 2 isoform 2; glucose-6-phosphatase, catalytic, related sequence; islet-specific glucose-6-phosphatase catalytic subunit-related protein", "tax_id": 10090, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:14378); (R-MMU-70263)", "pathway_count": 2, "publication_count": 53, "publication_id_list": "10078553;10078554;12815107;12878201;14722102;15220199;15843527;15908957;15937548;16424193;16493087;16979383;17229843;17237389;17265032;17620420;18354167;18390725;19966211;20220085;20299469;20381385;20439719;21346176;21825122;22194932;22539795;22678909;22829452;22872234;22908330;23155466;23934554;24246305;24387268;24435807;24550292;24777314;25165150;25728493;25958206;27069933;28344989;32152506;32928873;33154070;34203471;34668580;35007324;36214093;37855366;38785154;39121091", "class_list": "glycogene", "function": "Cis-acting elements elsewhere in IGRP gene may be required for determining appropriate IGRP tissue-specific expression and for maintenance of IGRP gene expression in adult mice., [RefSeq, PubMed]; G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity. Publication Status: Online-Only, [RefSeq, PubMed]; IGRP is likely the authentic islet-specific glucose-6-phosphatase catalytic subunit, and selective inhibitors to this molecule can be obtained., [RefSeq, PubMed]; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity)., [UniProtKB]; Multiple promoter and enhancer differences likely contribute to augmented G6PC2 expression in human versus mouse pancreatic islet alpha cells. Publication Status: Online-Only, [RefSeq, PubMed]; Possible association of G6PC2 and MUC6 induced by low-dose-rate irradiation in mouse intestine with inflammatory bowel disease., [RefSeq, PubMed]; This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AUN2;Q2M2M7", "ec_number_list": "3.1.3.94;3.1.3.25;3.1.3.9", "go_molecular_function": "GO:0004346 glucose-6-phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "Q9Z186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z247-1", "uniprot_id": "FKBP9_MOUSE", "mass": 62995.0, "length": 570, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP9", "gene_name": "Fkbp9", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP9 precursor", "refseq_ac": "NP_036186", "gene_names_uniprotkb": "Fkbp9; Fkbp60; Fkbp63", "gene_names_refseq": "1810014L23; FKBP-63; FKBP-9; FKBP60; FKBP63; FKBP65RS; Fkbp9", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP9; 5.2.1.8; 63 kDa FK506-binding protein; 63 kDa FKBP; FK506-binding protein 9; FKBP-63; FKBP-9; FKBP65RS; PPIase FKBP9; Rotamase", "protein_names_refseq": "63 kDa FK506-binding protein; 63 kDa FKBP; PPIase FKBP9; peptidyl-prolyl cis-trans isomerase FKBP9 precursor; peptidyl-prolyl cis-trans isomerase FKBP9; rotamase", "tax_id": 10090, "disease": "", "pathway": " (mmu:27055)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10524204;11710534;19349973;25428506;30899004;34428180", "class_list": "", "function": "Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family., [RefSeq, PubMed]; PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZZ6;Q8R386;Q9CVM0;Q9JHX5", "ec_number_list": "5.2.1.8;3.6.4.13;3.4.19.12;3.4.21.53;3.1.13.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPS3-1", "uniprot_id": "GLCE_MOUSE", "mass": 70089.0, "length": 618, "protein_name": "D-glucuronyl C5-epimerase", "gene_name": "Glce", "organism": "Mouse", "refseq_name": "D-glucuronyl C5-epimerase", "refseq_ac": "NP_201577", "gene_names_uniprotkb": "Glce", "gene_names_refseq": "1110017N23Rik; C130034A12Rik; Glce; Hsepi", "protein_names_uniprotkb": "D-glucuronyl C5-epimerase; 5.1.3.17; Heparan sulfate C5-epimerase; Heparin sulfate C5-epimerase; Heparin/heparan sulfate:glucuronic acid C5-epimerase; Heparosan-N-sulfate-glucuronate 5-epimerase; Hsepi", "protein_names_refseq": "D-glucuronyl C5-epimerase; heparan sulfate C5-epimerase; heparan sulfate-glucuronic acid C5-epimerase; heparin sulfate C5-epimerase; heparin/heparan sulfate:glucuronic acid C5-epimerase; heparosan-N-sulfate-glucuronate 5-epimerase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); cerebrovascular disease (Disease Ontology:DOID:6713)", "pathway": " (mmu:93683)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11274177;11279150;11687650;12788935;15292174;16532012;20208005;21750661;25428506;26495903;30899004;31219806;32651954;37217020;37828378", "class_list": "glycogene", "function": "Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development., [RefSeq, PubMed]; Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15., [RefSeq, PubMed]; NDST-1 and C5-epimerase have roles in heparan sulfate structure alterations in mouse tissue, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q505E6;Q99MM0", "ec_number_list": "5.1.3.17", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity;GO:0050379 UDP-glucuronate 5'-epimerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0060391 positive regulation of SMAD protein signal transduction;GO:0031345 negative regulation of cell projection organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9EPS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K349-1", "uniprot_id": "GIMA6_MOUSE", "mass": 34145.0, "length": 305, "protein_name": "GTPase IMAP family member 6", "gene_name": "Gimap6", "organism": "Mouse", "refseq_name": "GTPase IMAP family member 6", "refseq_ac": "NP_694815", "gene_names_uniprotkb": "Gimap6; Ian6", "gene_names_refseq": "4833419H03Rik; Gimap6; Ian6; mFLJ00102", "protein_names_uniprotkb": "GTPase IMAP family member 6; IAN-6; Immunity-associated nucleotide 6 protein; mIAN6", "protein_names_refseq": "GTPase IMAP family member 6; IAN-6; immune associated nucleotide 6; immunity-associated nucleotide 6 protein; mIAN6", "tax_id": 10090, "disease": "", "pathway": " (mmu:231931)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16509771;21750661;26495903;29718959;34428180;35551368", "class_list": "", "function": "GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans., [RefSeq, PubMed]; The results indicate a requirement for GIMAP6 in the maintenance of a normal peripheral adaptive immune system and a significant role for the protein in normal autophagic processes. Moreover, as GIMAP6 is expressed in a cell-selective manner, this indicates the potential existence of a cell-restricted mode of autophagic regulation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU66;Q8K434", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006955 immune response;GO:0001822 kidney development;GO:0006914 autophagy;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K349-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q75N62-1", "uniprot_id": "GIMA8_MOUSE", "mass": 76843.0, "length": 688, "protein_name": "GTPase IMAP family member 8", "gene_name": "Gimap8", "organism": "Mouse", "refseq_name": "GTPase IMAP family member 8 isoform 1", "refseq_ac": "NP_001070878", "gene_names_uniprotkb": "Gimap8; Ian9; Imap8", "gene_names_refseq": "Gimap8; Gm457; IAN9; IMAP8", "protein_names_uniprotkb": "GTPase IMAP family member 8; IAN-9; Immune-associated nucleotide-binding protein 9; Immunity-associated protein 8; mGIMAP8", "protein_names_refseq": "GTPase IMAP family member 8 isoform 1; immune-associated nucleotide-binding protein 9; immunity-associated protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:243374)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16088918;16509771;21750661;29187734;30084848;31219806;34428180;36210013", "class_list": "", "function": "Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections., [UniProtKB, PubMed, UniProtKB, UniProtKB]; GIMAP8 exerts an anti-apoptotic effect in the immune system and is involved in responses to infections, [RefSeq, PubMed]; This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein is larger than the other gene family members and includes three AIG1 domains (corresponding to the AIG1 protein from Arabidopsis thaliana) whereas other family members have one AIG1 domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZ12", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0070232 regulation of T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q75N62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHC0-1", "uniprot_id": "GPX2_MOUSE", "mass": 21990.0, "length": 190, "protein_name": "Glutathione peroxidase 2", "gene_name": "Gpx2", "organism": "Mouse", "refseq_name": "glutathione peroxidase 2", "refseq_ac": "NP_109602", "gene_names_uniprotkb": "Gpx2", "gene_names_refseq": "GI-GPx; GPx-GI; GSHPx-2; GSHPx-GI; Gpx2", "protein_names_uniprotkb": "Glutathione peroxidase 2; 1.11.1.12; 1.11.1.9; GPx-2; GPx-GI; GSHPx-2; GSHPx-GI; Glutathione peroxidase-gastrointestinal; Phospholipid hydroperoxide glutathione peroxidase GPX2", "protein_names_refseq": "GPx-2; glutathione peroxidase 2; glutathione peroxidase-gastrointestinal; intestinal GPx; phospholipid hydroperoxide glutathione peroxidase GPX2", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199); ulcerative colitis (Disease Ontology:DOID:8577); alcoholic gastritis (Disease Ontology:DOID:8680); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:14776); (R-MMU-2142712); (R-MMU-2142770); (R-MMU-3299685); (R-MMU-5628897)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "21750661;22872234;23977205;36002187;8661011;9685647", "class_list": "", "function": "Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. Cannot reduce phosphatidycholine hydroperoxide., [UniProtKB, UniProtKB]; GPX2 activity is confined to the mucosal epithelium of the GI tract. Activity is detected all along the crypt-villus axis with concentration in the crypts. GPX1 activity is found in all layers of the gut and all parts of the mucosal epithelium., [RefSeq, PubMed]; GPx2 is up-regulated in dysplastic colonic crypts, where it appears to act inhibit apoptosis and, thus, supports tumor development. Publication Status: Online-Only, [RefSeq, PubMed]; Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response., [RefSeq, PubMed]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract in rodents, is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Knockout studies in mice lacking this gene suggest a role for this isozyme in intestinal inflammation and colon cancer development. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 7. [provided by RefSeq, Aug 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2B2", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.11.1.12;1.11.1.9;5.3.3.-;1.11.1.27;1.16.3.1;1.16.3.4;2.5.1.-;5.3.99.3", "go_molecular_function": "GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051702 biological process involved in interaction with symbiont;GO:0009609 response to symbiotic bacterium;GO:0001659 temperature homeostasis;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46412-1", "uniprot_id": "GPX3_MOUSE", "mass": 25424.0, "length": 226, "protein_name": "Glutathione peroxidase 3", "gene_name": "Gpx3", "organism": "Mouse", "refseq_name": "glutathione peroxidase 3 isoform 2 precursor", "refseq_ac": "NP_001316789", "gene_names_uniprotkb": "Gpx3", "gene_names_refseq": "EGPx; GPx; GSHPx-3; GSHPx-P; Gpx3", "protein_names_uniprotkb": "Glutathione peroxidase 3; 1.11.1.9; GPx-3; GPx-P; GSHPx-3; GSHPx-P; Plasma glutathione peroxidase", "protein_names_refseq": "GPx-3; GPx-P; extracellular GPx; glutathione peroxidase 3 isoform 2 precursor; plasma GPx; plasma glutathione peroxidase", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); colorectal adenoma (Disease Ontology:DOID:0050860); stroke (Disease Ontology:DOID:0051061); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); stomach cancer (Disease Ontology:DOID:10534); mild pre-eclampsia (Disease Ontology:DOID:10590); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); nephrotic syndrome (Disease Ontology:DOID:1184); spermatic cord torsion (Disease Ontology:DOID:11996); male infertility (Disease Ontology:DOID:12336); cardiovascular system disease (Disease Ontology:DOID:1287); severe pre-eclampsia (Disease Ontology:DOID:13129); lung cancer (Disease Ontology:DOID:1324); depressive disorder (Disease Ontology:DOID:1596); congenital heart disease (Disease Ontology:DOID:1682); atherosclerosis (Disease Ontology:DOID:1936); rectum cancer (Disease Ontology:DOID:1993); transient cerebral ischemia (Disease Ontology:DOID:224); endometrial adenocarcinoma (Disease Ontology:DOID:2870); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); systemic scleroderma (Disease Ontology:DOID:418); esophagus adenocarcinoma (Disease Ontology:DOID:4914); gallbladder carcinoma (Disease Ontology:DOID:4948); esophageal cancer (Disease Ontology:DOID:5041); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); Barrett's adenocarcinoma (Disease Ontology:DOID:7941); lung disease (Disease Ontology:DOID:850); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14778); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;30084848;30779550;34428180;35799890;36583727;36880685;7929449;8566787", "class_list": "", "function": "GPx3 deficiency exacerbates maladaptive right ventricular remodeling in experimental pulmonary artery banding., [RefSeq, PubMed]; Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload. Publication Status: Online-Only, [RefSeq, PubMed]; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]., [RefSeq]; Vitamin D-vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XKR0", "ec_number_list": "1.11.1.12;1.11.1.9;1.11.1.27;1.16.3.1;1.16.3.4", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity;GO:0008430 selenium binding;GO:0045340 mercury ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0042744 hydrogen peroxide catabolic process;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P46412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PW74-1", "uniprot_id": "GIMD1_MOUSE", "mass": 24219.0, "length": 217, "protein_name": "GTPase IMAP family member GIMD1", "gene_name": "Gimd1", "organism": "Mouse", "refseq_name": "GTPase IMAP family member GIMD1", "refseq_ac": "NP_001257359", "gene_names_uniprotkb": "Gimd1; Gm5549", "gene_names_refseq": "EG433653; Gimd1; Gm5549", "protein_names_uniprotkb": "GTPase IMAP family member GIMD1; GIMAP family P-loop NTPase domain-containing protein 1", "protein_names_refseq": "GIMAP family P-loop NTPase domain-containing protein 1; GTPase IMAP family member GIMD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:433653)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PW74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61133-1", "uniprot_id": "GSTT2_MOUSE", "mass": 27634.0, "length": 244, "protein_name": "Glutathione S-transferase theta-2", "gene_name": "Gstt2", "organism": "Mouse", "refseq_name": "glutathione S-transferase theta-2 isoform b", "refseq_ac": "NP_034491", "gene_names_uniprotkb": "Gstt2", "gene_names_refseq": "Gstt2; Yrs; mGSTT2", "protein_names_uniprotkb": "Glutathione S-transferase theta-2; 2.5.1.18; GST class-theta-2", "protein_names_refseq": "GST class-theta-2; glutathione S-transferase theta-2 isoform b", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (mmu:14872); (R-MMU-156590)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;30783009;36210013;8617493;8761485", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB]; Glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 2 (GSTT2) were required in astrocytes for the enhancement of microglia activation during brain inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61134;Q64472;Q91VB0", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61133-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TC93-1", "uniprot_id": "H1BP3_MOUSE", "mass": 43691.0, "length": 395, "protein_name": "HCLS1-binding protein 3", "gene_name": "Hs1bp3", "organism": "Mouse", "refseq_name": "HCLS1-binding protein 3", "refseq_ac": "NP_067404", "gene_names_uniprotkb": "Hs1bp3", "gene_names_refseq": "Hs1bp3", "protein_names_uniprotkb": "HCLS1-binding protein 3; HS1-binding protein 3; HSP1BP-3", "protein_names_refseq": "HCLS1-binding protein 3; HS1 binding protein 3; HSP1BP-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:58240)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10590261;21750661;31219806;37828378", "class_list": "", "function": "May be a modulator of IL-2 signaling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLQ4;Q9Z1K1", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0042981 regulation of apoptotic process;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TC93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61450-1", "uniprot_id": "LRB4B_MOUSE", "mass": 34194.0, "length": 303, "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 4B", "gene_name": "Lilrb4b", "organism": "Mouse", "refseq_name": "leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 1 precursor", "refseq_ac": "NP_032173", "gene_names_uniprotkb": "Lilrb4b; Gp49a; Gp49; Lilr4b", "gene_names_refseq": "Gp49a; Lilr4b; Lilrb4b; gp49", "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily B member 4B; Mast cell surface glycoprotein Gp49A", "protein_names_refseq": "glycoprotein 49 A; leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 1 precursor; mast cell surface glycoprotein Gp49A", "tax_id": 10090, "disease": "", "pathway": " (mmu:14727)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10630292;10982834;11046024;1714901;21750661;36642505", "class_list": "", "function": "LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells., [RefSeq, PubMed]; Plays a role in mast cell activation., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q549E3", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0045576 mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61450-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z282-1", "uniprot_id": "GP132_MOUSE", "mass": 42653.0, "length": 382, "protein_name": "Probable G protein-coupled receptor 132", "gene_name": "Gpr132", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 132", "refseq_ac": "NP_064309", "gene_names_uniprotkb": "Gpr132; G2a", "gene_names_refseq": "G2a; Gpr132", "protein_names_uniprotkb": "Probable G protein-coupled receptor 132; G2 accumulation protein", "protein_names_refseq": "G protein-coupled receptor G2A; G2 accumulation protein; probable G-protein coupled receptor 132", "tax_id": 10090, "disease": "autoimmune disease (Disease Ontology:DOID:417)", "pathway": " (mmu:56696); (R-MMU-373076); (R-MMU-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12482833;14681556;15728718;21750661;25428506;25605945;26495903;34504016;36437247;37435068;9770487", "class_list": "", "function": "Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; G2A is expressed predominantly by macrophages within atherosclerotic lesions at the aortic root of apolipoprotein E-deficient mice., [RefSeq, PubMed]; Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis. Publication Status: Online-Only, [RefSeq, PubMed]; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity (By similarity)., [UniProtKB, PubMed]; Role of G2A in lysophosphatidylcholine-mediated T-cell migration, [RefSeq, PubMed]; The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBS4;Q3U5A4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle;GO:0010972 negative regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEJ1-1", "uniprot_id": "GPN2_MOUSE", "mass": 34540.0, "length": 310, "protein_name": "GPN-loop GTPase 2", "gene_name": "Gpn2", "organism": "Mouse", "refseq_name": "GPN-loop GTPase 2 isoform 1", "refseq_ac": "NP_598645", "gene_names_uniprotkb": "Gpn2; Atpbd1b", "gene_names_refseq": "Atpbd1b; Gpn2", "protein_names_uniprotkb": "GPN-loop GTPase 2; 3.6.5.-; ATP-binding domain 1 family member B", "protein_names_refseq": "ATP binding domain 1 family, member B; GPN-loop GTPase 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100210)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase RNA polymerase II and III (RNAPII and RNAPIII) complexes, ensuring their proper nuclear import., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A9E9", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VEJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AUQ7-1", "uniprot_id": "GTA1L_MOUSE", "mass": 37953.0, "length": 319, "protein_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1", "gene_name": "Ggta1l1", "organism": "Mouse", "refseq_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 precursor", "refseq_ac": "NP_083739", "gene_names_uniprotkb": "Ggta1l1", "gene_names_refseq": "4930568D16Rik; Ggta1l1", "protein_names_uniprotkb": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1; 2.4.1.87", "protein_names_refseq": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 precursor; N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4R9", "ec_number_list": "2.4.1.87", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2AUQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KGW5-1", "uniprot_id": "GT253_MOUSE", "mass": 67672.0, "length": 592, "protein_name": "Inactive glycosyltransferase 25 family member 3", "gene_name": "Cercam", "organism": "Mouse", "refseq_name": "inactive glycosyltransferase 25 family member 3 precursor", "refseq_ac": "NP_997181", "gene_names_uniprotkb": "Cercam; Ceecam1; Glt25d3", "gene_names_refseq": "2600006K01Rik; Ceecam1; Cercam", "protein_names_uniprotkb": "Inactive glycosyltransferase 25 family member 3; Cerebral endothelial cell adhesion molecule", "protein_names_refseq": "cerebral endothelial cell adhesion molecule 1; glycosyltransferase 25 family member 3; inactive glycosyltransferase 25 family member 3 precursor; probable inactive glycosyltransferase 25 family member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:99151)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506", "class_list": "glycogene;glycosyltransferase", "function": "Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A3KGW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4FUP9-1", "uniprot_id": "GL1D1_MOUSE", "mass": 38841.0, "length": 346, "protein_name": "Glycosyltransferase 1 domain-containing protein 1", "gene_name": "Glt1d1", "organism": "Mouse", "refseq_name": "glycosyltransferase 1 domain-containing protein 1 precursor", "refseq_ac": "NP_795979", "gene_names_uniprotkb": "Glt1d1", "gene_names_refseq": "5730455A04Rik; Glt1d1", "protein_names_uniprotkb": "Glycosyltransferase 1 domain-containing protein 1; 2.4.-.-", "protein_names_refseq": "glycosyltransferase 1 domain-containing protein 1 precursor; glycosyltransferase 1 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319804)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "glycogene;glycosyltransferase", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWP4", "ec_number_list": "", "go_molecular_function": "GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FUP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B9EJV3-1", "uniprot_id": "GRB1L_MOUSE", "mass": 213628.0, "length": 1913, "protein_name": "GREB1-like protein", "gene_name": "Greb1l", "organism": "Mouse", "refseq_name": "GREB1-like protein", "refseq_ac": "NP_001077097", "gene_names_uniprotkb": "Greb1l; Kiaa4095", "gene_names_refseq": "Greb1l; mKIAA4095", "protein_names_uniprotkb": "GREB1-like protein", "protein_names_refseq": "GREB1-like protein", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 80 (Disease Ontology:DOID:0070602); renal agenesis (Disease Ontology:DOID:14766)", "pathway": " (mmu:381157)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;29100090;29100091;29955957;37852253", "class_list": "", "function": "Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells., [RefSeq, PubMed]; Plays a major role in early metanephros and genital development., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTN6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0060562 epithelial tube morphogenesis;GO:0003231 cardiac ventricle development;GO:0001822 kidney development;GO:0042254 ribosome biogenesis;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B9EJV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0N2-1", "uniprot_id": "GPAT3_MOUSE", "mass": 49000.0, "length": 438, "protein_name": "Glycerol-3-phosphate acyltransferase 3", "gene_name": "Gpat3", "organism": "Mouse", "refseq_name": "glycerol-3-phosphate acyltransferase 3", "refseq_ac": "NP_766303", "gene_names_uniprotkb": "Gpat3; Agpat9", "gene_names_refseq": "1-AGPAT 9; 1-AGPAT; 4933407I02Rik; 4933408F15; A230097K15Rik; AGPAT 10; Agpat9; GPAT-3; Gpat3; mGPAT3", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 3; 1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 2.3.1.15; 2.3.1.51; AGPAT 10; Acyl-CoA:glycerol-3-phosphate acyltransferase 3; GPAT-3; LPAAT-theta; Lysophosphatidic acid acyltransferase theta; mGPAT3", "protein_names_refseq": "1-AGP acyltransferase 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 1-acylglycerol-3-phosphate O-acyltransferase 9; LPAAT-theta; acyl-CoA:glycerol-3-phosphate acyltransferase 3; glycerol-3-phosphate acyltransferase 3; lysophosphatidic acid acyltransferase theta", "tax_id": 10090, "disease": "", "pathway": " (mmu:231510); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11003606;17170135;17242355;18630941;19144319;21183079;21750661;24714397;25428506;26644473;30084848;31219806;31873720;32094408;34428180", "class_list": "", "function": "Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Protects cells against lipotoxicity (By similarity)., [UniProtKB, UniProtKB, PubMed]; GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy., [RefSeq, PubMed]; GPAT3 is the primary GPAT in white adipose tissue and has an important role of the enzyme in regulating energy, glucose, and lipid homeostasis., [RefSeq, PubMed]; Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; These studies identify GPAT3 as a novel enzyme involved in intestinal lipid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5X0", "ec_number_list": "2.3.1.51;2.3.1.15;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.-;2.3.1.121;2.3.1.n6;2.3.1.n7;3.1.1.4;3.1.1.3", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process;GO:0032006 regulation of TOR signaling;GO:0008654 phospholipid biosynthetic process;GO:0006072 glycerol-3-phosphate metabolic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8C0N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JY3-1", "uniprot_id": "GIMA4_MOUSE", "mass": 38044.0, "length": 328, "protein_name": "GTPase IMAP family member 4", "gene_name": "Gimap4", "organism": "Mouse", "refseq_name": "GTPase IMAP family member 4 isoform c", "refseq_ac": "NP_001230128", "gene_names_uniprotkb": "Gimap4; Ian1; Imap4", "gene_names_refseq": "E430007K16Rik; Gimap4; Ian-1; Ian1; Imap4", "protein_names_uniprotkb": "GTPase IMAP family member 4; IAN-1; Immunity-associated nucleotide 1 protein; Immunity-associated protein 4", "protein_names_refseq": "GTPase IMAP family member 4 isoform c; immune associated nucleotide 1; immunity-associated protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:107526)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16509771;16569770;21750661;25428506", "class_list": "", "function": "During thymocyte development, may play a role in the regulation of apoptosis., [UniProtKB, PubMed, PubMed]; Gimap4 accelerates the execution of programmed cell death induced by intrinsic stimuli downstream of caspase-3 activation and phosphatidylserine exposure. Apoptosis directly correlates with the phosphorylation status of Gimap4., [RefSeq, PubMed]; This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. This gene exists within a cluster of other related genes located on mouse chromosome 6. This family member encodes a lymphoid signaling protein that functions to accelerate programmed T-cell death, which appears to correlate with the phosphorylation status of the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YTN4", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99JY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61599-1", "uniprot_id": "GDIR2_MOUSE", "mass": 22851.0, "length": 200, "protein_name": "Rho GDP-dissociation inhibitor 2", "gene_name": "Arhgdib", "organism": "Mouse", "refseq_name": "rho GDP-dissociation inhibitor 2 isoform 1", "refseq_ac": "NP_001288230", "gene_names_uniprotkb": "Arhgdib; Gdid4", "gene_names_refseq": "Arhgdib; D4; Gdid4; Ly-GDI", "protein_names_uniprotkb": "Rho GDP-dissociation inhibitor 2; D4; Rho GDI 2; Rho-GDI beta", "protein_names_refseq": "Rho, GDP dissociation inhibitor (GDI) beta; rho GDI 2; rho GDP-dissociation inhibitor 2 isoform 1; rho GDP-dissociation inhibitor 2; rho-GDI beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:11857); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "17049467;17142749;21518140;21750661;22777355;25778399;26469087;26495903;26740625;28011936;35820727;7512369", "class_list": "", "function": "Impaired interaction of RhoGDIbeta with Rac1 isoprenyl groups possibly makes RhoGDIbeta function as a positive regulator for Rac1 during metastasis., [RefSeq, PubMed]; Ly-GDI is a critical regulator of inflammatory injury after deposition of IgG immune complexes and that it negatively regulates the lung NF-kappaB activity. Publication Status: Online-Only, [RefSeq, PubMed]; Raptor siRNA suppressed the effects of GM3 on Ly-GDI expression and Akt phosphorylation at Thr(308) , suggesting GM3 signals to be transduced to mTOR-Raptor and Akt-Thr(308) , leading to Ly-GDI stimulation, [RefSeq, PubMed]; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members., [UniProtKB, UniProtKB]; Rho GDIalpha and Rho GDIbeta play synergistic roles in lymphocyte migration and development by modulating activation cycle of the Rho proteins in a lymphoid organ-specific manner., [RefSeq, PubMed]; Rictor regulates cell migration by suppressing RhoGDI2., [RefSeq, PubMed]; The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]., [RefSeq]; These results indicate that RhoGDIbeta functions as a novel BMP4 signaling target that regulates adipogenesis and myogensis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEB3", "ec_number_list": "", "go_molecular_function": "GO:0005094 Rho GDP-dissociation inhibitor activity;GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:1901164 negative regulation of trophoblast cell migration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61599-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922H4-1", "uniprot_id": "GMPPA_MOUSE", "mass": 46244.0, "length": 420, "protein_name": "Mannose-1-phosphate guanylyltransferase regulatory subunit alpha", "gene_name": "Gmppa", "organism": "Mouse", "refseq_name": "mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1", "refseq_ac": "NP_598469", "gene_names_uniprotkb": "Gmppa", "gene_names_refseq": "1810012N01Rik; Gmppa", "protein_names_uniprotkb": "Mannose-1-phosphate guanylyltransferase regulatory subunit alpha; GDP-mannose pyrophosphorylase A; GTP-mannose-1-phosphate guanylyltransferase alpha", "protein_names_refseq": "GTP-mannose-1-phosphate guanylyltransferase alpha; mannose-1-phosphate guanyltransferase alpha; mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1; mannose-1-phosphate guanylyltransferase regulatory subunit alpha", "tax_id": 10090, "disease": "alacrima, achalasia, and impaired intellectual development syndrome (Disease Ontology:DOID:0112321)", "pathway": " (mmu:69080); (R-MMU-446205)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;24035193;26495903;31219806;33755596;34428180;35820727;40684658", "class_list": "glycogene", "function": "GMPPA defects cause a neuromuscular disorder with alpha-dystroglycan hyperglycosylation., [RefSeq, PubMed]; Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex. Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose. Together with GMPPB regulates GDP-alpha-D-mannose levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCM2", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0016740 transferase activity;GO:0140299 molecular sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0120508 GDP-mannose pyrophosphorylase complex", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0019673 GDP-mannose metabolic process;GO:0050890 cognition;GO:0050905 neuromuscular process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q922H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LE2-1", "uniprot_id": "GP146_MOUSE", "mass": 36572.0, "length": 333, "protein_name": "G protein-coupled receptor 146", "gene_name": "Gpr146", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 146", "refseq_ac": "NP_001033792", "gene_names_uniprotkb": "Gpr146", "gene_names_refseq": "D830046C22Rik; Gpr146; PGR8", "protein_names_uniprotkb": "G protein-coupled receptor 146", "protein_names_refseq": "G-protein coupled receptor 146; probable G-protein coupled receptor 146", "tax_id": 10090, "disease": "", "pathway": " (mmu:80290)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;25428506;28464285;30084848;30779550;31778654;32203133;34428180;37926274;38503280", "class_list": "", "function": "GPCR receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280)., [UniProtKB, PubMed, PubMed]; GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling., [RefSeq, PubMed]; GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase., [RefSeq, PubMed]; Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice., [RefSeq, PubMed]; These findings outline a regulatory role for the GPR146/ERK axis in systemic cholesterol metabolism., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3K8;Q3U421;Q8BHR6;Q8BHU4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0051607 defense response to virus;GO:0045540 regulation of cholesterol biosynthetic process;GO:0009615 response to virus;GO:0045542 positive regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99LE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U3F9-1", "uniprot_id": "GP160_MOUSE", "mass": 38922.0, "length": 336, "protein_name": "Probable G protein-coupled receptor 160", "gene_name": "Gpr160", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 160", "refseq_ac": "NP_001127857", "gene_names_uniprotkb": "Gpr160", "gene_names_refseq": "1700025D19Rik; GPCR150; Gpr160", "protein_names_uniprotkb": "Probable G protein-coupled receptor 160", "protein_names_refseq": "probable G-protein coupled receptor 160", "tax_id": 10090, "disease": "", "pathway": " (mmu:71862)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;27259691;38198232;38750952", "class_list": "", "function": "Behavioral characterization of G-protein-coupled receptor 160 knockout mice., [RefSeq, PubMed]; GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; These findings suggest an important role of GPR160 in regulating the entry of BCG into macrophages by targeting the ERK signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9Y9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3U3F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6K1E7-1", "uniprot_id": "GGNB1_MOUSE", "mass": 40505.0, "length": 370, "protein_name": "Gametogenetin-binding protein 1", "gene_name": "Ggnbp1", "organism": "Mouse", "refseq_name": "gametogenetin-binding protein 1 isoform a", "refseq_ac": "NP_081820", "gene_names_uniprotkb": "Ggnbp1", "gene_names_refseq": "0610031G08Rik; Ggnbp1; mdf", "protein_names_uniprotkb": "Gametogenetin-binding protein 1", "protein_names_refseq": "deubiquitinating enzyme Usp15; gametogenetin-binding protein 1 isoform a; gametogenin binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70772)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15625700;15642376;15892049;19208545;21750661;32139124;38236177", "class_list": "", "function": "A testicular germ cell-specific protein interacting with GGN1. The protein seems to associate with the membrane system in the germ cell., [RefSeq, PubMed]; GGNBP1 ensures proper spermiogenesis in response to stress in mice., [RefSeq, PubMed]; GGNBP1 is involved in spermatogenesis by modifying mitochondrial dynamics and morphology., [RefSeq, PubMed]; Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9WZ58;Q8C5T9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6K1E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCE2-1", "uniprot_id": "GPN1_MOUSE", "mass": 41598.0, "length": 372, "protein_name": "GPN-loop GTPase 1", "gene_name": "Gpn1", "organism": "Mouse", "refseq_name": "GPN-loop GTPase 1", "refseq_ac": "NP_598517", "gene_names_uniprotkb": "Gpn1; Mbdin; Xab1", "gene_names_refseq": "2410004J02Rik; Gpn1; MBDIN; NTPBP; Xab1", "protein_names_uniprotkb": "GPN-loop GTPase 1; 3.6.5.-; MBD2-interacting protein; MBDin; XPA-binding protein 1", "protein_names_refseq": "GPN-loop GTPase 1; MBD2-interacting protein; XPA binding protein 1; methyl-CpG binding domain protein 2 interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74254)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;34428180", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII (By similarity). In vitro, exhibits a chaperone-like activity and a chaperone substrate protein can stimulate its GTPase activity. It is proposed to bind exposed hydrophobic peptide regions of newly synthesized RNAP II subunit, triggering the opening of a hydrophobic pocket in its GDP-bound state. This interaction likely traps exposed hydrophobic regions, preventing misassembly and providing a time window for association with the cognate RNAP II subunit. Peptide binding promotes GDP release, and increasing GTP affinity to facilitate GTP rebinding. Subsequent GTP hydrolysis would then lead to the release of the bound RNAP II subunit to enable association with cognate subunits and RNAP II assembly (By similarity). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0000993 RNA polymerase II complex binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VCE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62160-1", "uniprot_id": "GDIR3_MOUSE", "mass": 25296.0, "length": 225, "protein_name": "Rho GDP-dissociation inhibitor 3", "gene_name": "Arhgdig", "organism": "Mouse", "refseq_name": "rho GDP-dissociation inhibitor 3", "refseq_ac": "NP_032139", "gene_names_uniprotkb": "Arhgdig; Gdi5", "gene_names_refseq": "Arhgdig; Gdi5; RIP2; Rho-GDI-3; Rho-GDI2", "protein_names_uniprotkb": "Rho GDP-dissociation inhibitor 3; Rho GDI 3; Rho-GDI gamma; Rho-GDI2", "protein_names_refseq": "Rho GDP dissociation inhibitor (GDI) gamma; guanosine diphosphate (GDP) dissociation inhibitor 5, Rho associated; rho GDI 3; rho GDP-dissociation inhibitor 3; rho-GDI gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:14570); (R-MMU-9013026); (R-MMU-9013148); (R-MMU-9013407); (R-MMU-9013408)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "21750661;23996536;25274045;8939998", "class_list": "", "function": "Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP., [UniProtKB, UniProtKB, UniProtKB]; Our results indicate that the overexpression of Rho-GDIgamma maintains Neural stem cells in the stem cell state preventing migration, [RefSeq, PubMed]; RhoGDI2 is required for PKB and CREB activation and cdc42 expression in astrocyte migration after kainic acid-mediated excitotoxic lesion in mouse brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005094 Rho GDP-dissociation inhibitor activity;GO:0005096 GTPase activator activity;GO:0030695 GTPase regulator activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0032880 regulation of protein localization;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62160-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58929-1", "uniprot_id": "GMEB2_MOUSE", "mass": 56631.0, "length": 530, "protein_name": "Glucocorticoid modulatory element-binding protein 2", "gene_name": "Gmeb2", "organism": "Mouse", "refseq_name": "glucocorticoid modulatory element-binding protein 2", "refseq_ac": "NP_937812", "gene_names_uniprotkb": "Gmeb2", "gene_names_refseq": "Gmeb2", "protein_names_uniprotkb": "Glucocorticoid modulatory element-binding protein 2; GMEB-2", "protein_names_refseq": "GMEB-2; glucocorticoid modulatory element-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:229004)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21750661;22517741;22872234;25428506;29237092;30084848;30779550;32782141;32848054;34428180;34678516;35822049;36852467;40885482", "class_list": "", "function": "Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCY0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P58929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHK3-1", "uniprot_id": "GREB1_MOUSE", "mass": 216927.0, "length": 1954, "protein_name": "Protein GREB1", "gene_name": "Greb1", "organism": "Mouse", "refseq_name": "protein GREB1 isoform 1", "refseq_ac": "NP_056579", "gene_names_uniprotkb": "Greb1; Kiaa0575", "gene_names_refseq": "5730583K22Rik; 9130004E13; Greb1; mKIAA0575", "protein_names_uniprotkb": "Protein GREB1", "protein_names_refseq": "protein GREB1 isoform 1; protein GREB1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268527); (R-MMU-9018519)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10644441;21750661;33731348;38431630", "class_list": "", "function": "A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis. Publication Status: Online-Only, [RefSeq, PubMed]; GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERalpha glycosylation and stability to cancer. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in estrogen-stimulated cell proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E0CYB3;Q8BZT6;Q8CHE7;Q9JLG7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UHK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14246-1", "uniprot_id": "GTR2_MOUSE", "mass": 57107.0, "length": 523, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 2", "gene_name": "Slc2a2", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 2", "refseq_ac": "NP_112474", "gene_names_uniprotkb": "Slc2a2; Glut2", "gene_names_refseq": "Glut-2; Glut2; Slc2a2", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 2; GLUT-2; Glucose transporter type 2, liver", "protein_names_refseq": "glucose transporter type 2, liver; liver-type glucose transporter; solute carrier family 2, facilitated glucose transporter member 2", "tax_id": 10090, "disease": "Fanconi-Bickel syndrome (Disease Ontology:DOID:0070562); glycogen storage disease (Disease Ontology:DOID:2747); insulinoma (Disease Ontology:DOID:3892); gastrinoma (Disease Ontology:DOID:5577); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20526); (R-MMU-189200); (R-MMU-422356); (R-MMU-8981373)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "1289053;16377570;17242355;1765007;21183079;21750661;2602116;2771649;30084848;34428180;37453647;39334386;7929431", "class_list": "glycogene", "function": "Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate and urate., [UniProtKB, UniProtKB]; Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNA5;Q9DBA7", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005158 insulin receptor binding;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005911 cell-cell junction", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0008643 carbohydrate transport;GO:0015755 fructose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P14246-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50149-1", "uniprot_id": "GNAT2_MOUSE", "mass": 40118.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-2", "gene_name": "Gnat2", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-2", "refseq_ac": "NP_032167", "gene_names_uniprotkb": "Gnat2", "gene_names_refseq": "Gnat-2; Gnat2; Gt-2; Hg1d; Tcalpha", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha-2 chain", "protein_names_refseq": "guanine nucleotide binding protein, alpha transducing 2; guanine nucleotide-binding protein G(t) subunit alpha-2; heterotrimeric guanine nucleotide-binding protein 1d; transducin alpha-2 chain", "tax_id": 10090, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); achromatopsia 4 (Disease Ontology:DOID:0110010); color blindness (Disease Ontology:DOID:13399); achromatopsia (Disease Ontology:DOID:13911); McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:14686); (R-MMU-4086398); (R-MMU-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31696965;8013366", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0009583 detection of light stimulus;GO:0048877 homeostasis of number of retina cells;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50149-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WG8-1", "uniprot_id": "GLCNE_MOUSE", "mass": 79199.0, "length": 722, "protein_name": "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "gene_name": "Gne", "organism": "Mouse", "refseq_name": "bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1", "refseq_ac": "NP_001177343", "gene_names_uniprotkb": "Gne; Glcne; Uae1", "gene_names_refseq": "2310066H07Rik; DMRV; GLCNE; Gne; IBM2; NM; Uae1", "protein_names_uniprotkb": "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; ManAc kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimerase", "protein_names_refseq": "UDP-GlcNAc-2-epimerase/ManAc kinase; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "tax_id": 10090, "disease": "GNE myopathy (Disease Ontology:DOID:0080718); thrombocytopenia (Disease Ontology:DOID:1588); sialuria (Disease Ontology:DOID:3659)", "pathway": " (mmu:50798); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10103025;10745088;11929971;21750661;25428506;30084848;30779550;34428180;38224318;38237079;38875046", "class_list": "glycogene", "function": "Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation, playing a role in embryonic angiogenesis (PubMed:11929971, PubMed:38237079). Sialic acids represent a category of negatively charged sugars that reside on the surface of cells as terminal components of glycoconjugates and mediate important functions in various cellular processes, including cell adhesion, signal transduction, and cellular recognition (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; GNE deficiency impairs Myogenesis in C2C12 cells and cannot be rescued by ManNAc supplementation., [RefSeq, PubMed]; Inactivation of the UDP-GlcNAc 2-epimerase by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development, [RefSeq, PubMed]; Induced Muscle and Liver Absence of Gne in Postnatal Mice Does Not Result in Structural or Functional Muscle Impairment., [RefSeq, PubMed]; Novel GNE missense variants impair de novo sialylation and cause defective angiogenesis in the developing brain in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC83;Q8CCB0;Q9Z0P6", "ec_number_list": "2.7.1.60;3.2.1.183", "go_molecular_function": "GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity;GO:0009384 N-acylmannosamine kinase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006045 N-acetylglucosamine biosynthetic process;GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process;GO:0046380 N-acetylneuraminate biosynthetic process;GO:0006047 UDP-N-acetylglucosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91WG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WR6-1", "uniprot_id": "GINM1_MOUSE", "mass": 36079.0, "length": 327, "protein_name": "Glycoprotein integral membrane protein 1", "gene_name": "Ginm1", "organism": "Mouse", "refseq_name": "glycoprotein integral membrane protein 1 isoform 1 precursor", "refseq_ac": "NP_663393", "gene_names_uniprotkb": "Ginm1", "gene_names_refseq": "Ginm1", "protein_names_uniprotkb": "Glycoprotein integral membrane protein 1", "protein_names_refseq": "glycoprotein integral membrane protein 1 isoform 1 precursor; glycoprotein integral membrane protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215751)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30084848;32152506", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91WR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKV1-1", "uniprot_id": "GPC2_MOUSE", "mass": 63344.0, "length": 579, "protein_name": "Glypican-2", "gene_name": "Gpc2", "organism": "Mouse", "refseq_name": "glypican-2 isoform 1 precursor", "refseq_ac": "NP_766000", "gene_names_uniprotkb": "Gpc2", "gene_names_refseq": "2410016G05Rik; Gpc2", "protein_names_uniprotkb": "Glypican-2", "protein_names_refseq": "glypican-2 isoform 1 precursor; glypican-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71951); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "21750661", "class_list": "glycogene", "function": "Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity)., [UniProtKB]; Cell surface proteoglycan., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0016477 cell migration;GO:0030182 neuron differentiation;GO:0009966 regulation of signal transduction;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BKV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NB5-1", "uniprot_id": "GSDMC_MOUSE", "mass": 52743.0, "length": 468, "protein_name": "Gasdermin-C", "gene_name": "Gsdmc", "organism": "Mouse", "refseq_name": "gasdermin-C", "refseq_ac": "NP_113555", "gene_names_uniprotkb": "Gsdmc; Gsdmc1; Mlze", "gene_names_refseq": "Gsdmc1; Gsdmc; Mlze", "protein_names_uniprotkb": "Gasdermin-C; Gasdermin-C1; Melanoma-derived leucine zipper-containing extranuclear factor; mMLZE", "protein_names_refseq": "gasdermin C1; gasdermin-C; melanoma-derived leucine zipper, extra-nuclear factor; melanoma-derived leucine zipper-containing extranuclear factor", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:83492)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11223543;17350798;21750661;34428180", "class_list": "", "function": "Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis., [UniProtKB, UniProtKB]; This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99NB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2W8-1", "uniprot_id": "GRIA4_MOUSE", "mass": 100847.0, "length": 902, "protein_name": "Glutamate receptor 4", "gene_name": "Gria4", "organism": "Mouse", "refseq_name": "glutamate receptor 4 isoform 3 precursor", "refseq_ac": "NP_001106652", "gene_names_uniprotkb": "Gria4; Glur4", "gene_names_refseq": "GluA4; GluR-D; Glur-4; Glur4; Gluralpha4; Gria4; spkw1", "protein_names_uniprotkb": "Glutamate receptor 4; AMPA-selective glutamate receptor 4; GluA4; GluR-4; GluR-D; GluR4; Glutamate receptor ionotropic, AMPA 4", "protein_names_refseq": "AMPA-selective glutamate receptor 4; glutamate receptor 4 isoform 3 precursor; glutamate receptor 4; glutamate receptor channel alpha 4; glutamate receptor ionotropic, AMPA 4; spike wave 1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); central nervous system disease (Disease Ontology:DOID:331); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:14802); (R-MMU-399710); (R-MMU-399719); (R-MMU-416993); (R-MMU-438066); (R-MMU-8849932)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16129400;21183079;21750661;22645316;30899004;33300544;33981040;34203471", "class_list": "", "function": "Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]., [RefSeq]; Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9M7", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004970 glutamate-gated receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0034392 negative regulation of smooth muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9Z2W8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08742-1", "uniprot_id": "GPV_MOUSE", "mass": 63468.0, "length": 567, "protein_name": "Platelet glycoprotein V", "gene_name": "Gp5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gp5", "gene_names_refseq": "", "protein_names_uniprotkb": "Platelet glycoprotein V; GPV; Glycoprotein 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:14729); (R-MMU-430116); (R-MMU-76009); (R-MMU-9769739); (R-MMU-9769743); (R-MMU-9935598)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;9129030", "class_list": "", "function": "The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0009986 cell surface;GO:1990779 glycoprotein Ib-IX-V complex;GO:0016020 membrane", "go_biological_process": "GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0007160 cell-matrix adhesion;GO:0051209 release of sequestered calcium ion into cytosol;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88396-1", "uniprot_id": "GRPE2_MOUSE", "mass": 25030.0, "length": 224, "protein_name": "GrpE protein homolog 2, mitochondrial", "gene_name": "Grpel2", "organism": "Mouse", "refseq_name": "grpE protein homolog 2, mitochondrial precursor", "refseq_ac": "NP_067271", "gene_names_uniprotkb": "Grpel2; Mt-grpel2", "gene_names_refseq": "Grpel2; mt-GrpE#2; mt-Grpel2", "protein_names_uniprotkb": "GrpE protein homolog 2, mitochondrial; Mt-GrpE#2", "protein_names_refseq": "grpE protein homolog 2, mitochondrial precursor; grpE protein homolog 2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:17714)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22645316;36927450;9694873", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70., [UniProtKB]; Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULH8;Q9CQ97", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006457 protein folding;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88396-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30731-1", "uniprot_id": "GPR83_MOUSE", "mass": 48137.0, "length": 423, "protein_name": "G protein-coupled receptor 83", "gene_name": "Gpr83", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 83 isoform 1 precursor", "refseq_ac": "NP_034417", "gene_names_uniprotkb": "Gpr83; Gir; Gpr72; Jp05", "gene_names_refseq": "Gir; Gpr72; Gpr83; RP105; RP39; RP82", "protein_names_uniprotkb": "G protein-coupled receptor 83; Glucocorticoid-induced receptor", "protein_names_refseq": "G-protein coupled receptor 83 isoform 1 precursor; glucocorticoid-induced receptor; probable G-protein coupled receptor 83", "tax_id": 10090, "disease": "", "pathway": " (mmu:14608); (R-MMU-418555)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1663214;23744028;25428506;27117253;34512237;35605991;9675427", "class_list": "", "function": "G protein-coupled peptide receptor (PubMed:27117253, PubMed:35605991). G protein-coupled peptide receptor. Several peptides, PEN, derived from the proSAAS precursor (PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways. However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain (PubMed:27117253, PubMed:35605991). Plays a role in food intake and body weight regulation (PubMed:23744028). May contribute to the regulation of anxiety-related behaviors (PubMed:34512237)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q542Q9;Q544C4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097730 non-motile cilium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0051384 response to glucocorticoid;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36916-1", "uniprot_id": "GNL1_MOUSE", "mass": 68771.0, "length": 607, "protein_name": "Guanine nucleotide-binding protein-like 1", "gene_name": "Gnl1", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein-like 1", "refseq_ac": "NP_032162", "gene_names_uniprotkb": "Gnl1; Gna-rs1; Mmr1", "gene_names_refseq": "Gna-rs1; Gnal1; Gnl1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 1; GTP-binding protein MMR1", "protein_names_refseq": "GTP-binding protein MMR1; guanine nucleotide binding protein, related sequence 1; guanine nucleotide-binding protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14670)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1478666;21183079;31219806;33300544;36210013", "class_list": "", "function": "Possible regulatory or functional link with the histocompatibility cluster., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPZ9;Q91Z20", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36916-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70259-1", "uniprot_id": "GP143_MOUSE", "mass": 44564.0, "length": 405, "protein_name": "G protein-coupled receptor 143", "gene_name": "Gpr143", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 143", "refseq_ac": "NP_035081", "gene_names_uniprotkb": "Gpr143; Oa1", "gene_names_refseq": "Gpr143; Oa1", "protein_names_uniprotkb": "G protein-coupled receptor 143; MOA1; Ocular albinism type 1 protein homolog", "protein_names_refseq": "G-protein coupled receptor 143; MOA1; homolog of human ocular albinism 1 (Nettleship-Falls); ocular albinism type 1 protein homolog", "tax_id": 10090, "disease": "ocular albinism 1 (Disease Ontology:DOID:0050633); congenital nystagmus 6 (Disease Ontology:DOID:0111795)", "pathway": " (mmu:18241); (R-MMU-375280); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18697795;24650003;25601010;8889556;8921399", "class_list": "", "function": "Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL expression., [RefSeq, PubMed]; OA1 expression in both neuronal and non-neuronal tissues was examined by immunohistochemical analyses, results suggested that OA1 may modulate the monoaminergic functions in both peripheral and central nervous systems, [RefSeq, PubMed]; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O89031", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0035643 L-DOPA receptor activity;GO:0035240 dopamine binding;GO:0072544 L-DOPA binding;GO:0072545 L-tyrosine binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0032438 melanosome organization;GO:0032402 melanosome transport;GO:0032400 melanosome localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70259-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97494-1", "uniprot_id": "GSH1_MOUSE", "mass": 72571.0, "length": 637, "protein_name": "Glutamate--cysteine ligase catalytic subunit", "gene_name": "Gclc", "organism": "Mouse", "refseq_name": "glutamate--cysteine ligase catalytic subunit", "refseq_ac": "NP_034425", "gene_names_uniprotkb": "Gclc; Glclc", "gene_names_refseq": "D9Wsu168e; GLCL-H; Gclc; Ggcs-hs; Glclc", "protein_names_uniprotkb": "Glutamate--cysteine ligase catalytic subunit; 6.3.2.2; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase", "protein_names_refseq": "GCS heavy chain; gamma GCS-HS; gamma-ECS; gamma-glutamylcysteine synthetase heavy subunit; glutamate--cysteine ligase catalytic subunit", "tax_id": 10090, "disease": "congenital nonspherocytic hemolytic anemia 7 (Disease Ontology:DOID:0111681); cystic fibrosis (Disease Ontology:DOID:1485); liver cirrhosis (Disease Ontology:DOID:5082); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cataract (Disease Ontology:DOID:83); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:14629); (R-MMU-174403)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16608839;25428506;30084848;30779550;31599954;34418053;34428180;37453647;9223101;9224945", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09166;Q8VCS5", "ec_number_list": "6.3.2.2", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0044877 protein-containing complex binding;GO:0004357 glutamate-cysteine ligase activity", "go_cellular_component": "GO:0017109 glutamate-cysteine ligase complex;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0046685 response to arsenic-containing substance;GO:0051900 regulation of mitochondrial depolarization;GO:0097069 cellular response to thyroxine stimulus;GO:0006536 glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97494-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02596-1", "uniprot_id": "GLCM1_MOUSE", "mass": 16209.0, "length": 151, "protein_name": "Glycosylation-dependent cell adhesion molecule 1", "gene_name": "Glycam1", "organism": "Mouse", "refseq_name": "glycosylation-dependent cell adhesion molecule 1 isoform 2 precursor", "refseq_ac": "NP_032160", "gene_names_uniprotkb": "Glycam1", "gene_names_refseq": "Glycam1; MC26; Sgp50; glyCAM-1", "protein_names_uniprotkb": "Glycosylation-dependent cell adhesion molecule 1; Endothelial ligand FOR L-selectin; GlyCAM-1; MC26; SGP50; Sulfated 50 kDa glycoprotein", "protein_names_refseq": "GlyCAM 1; Glycosylation-dependent cell adhesion molecule 1; Sele ligand; endothelial ligand FOR L-selectin; glycosylation-dependent cell adhesion molecule 1 isoform 2 precursor; sulfated 50 kDa glycoprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14663)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1376638;21750661;28446179;7538131;7680041;8276769", "class_list": "glycogene", "function": "Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin., [UniProtKB]; GlyCam1 levels modulate immune cell entry from the vasculature into neural tissues. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6D0", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0043199 sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2NKH9-1", "uniprot_id": "GL6D1_MOUSE", "mass": 37081.0, "length": 311, "protein_name": "Glycosyltransferase 6 domain-containing protein 1", "gene_name": "Glt6d1", "organism": "Mouse", "refseq_name": "glycosyltransferase 6 domain-containing protein 1 isoform 1", "refseq_ac": "NP_001034184", "gene_names_uniprotkb": "Glt6d1", "gene_names_refseq": "4933411C14Rik; GT6m7; Glt6d1", "protein_names_uniprotkb": "Glycosyltransferase 6 domain-containing protein 1; 2.4.1.-", "protein_names_refseq": "glycosyltransferase 6 domain-containing protein 1 isoform 1; glycosyltransferase 6 domain-containing protein 1; novel glycosyltransferase family 6 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0031982 vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NKH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TCV3-1", "uniprot_id": "GSAP_MOUSE", "mass": 98694.0, "length": 858, "protein_name": "Gamma-secretase-activating protein", "gene_name": "Gsap", "organism": "Mouse", "refseq_name": "gamma-secretase-activating protein isoform 1", "refseq_ac": "NP_780646", "gene_names_uniprotkb": "Gsap; Pion", "gene_names_refseq": "A530088I07Rik; Gsap; Pion", "protein_names_uniprotkb": "Gamma-secretase-activating protein; GSAP; Protein pigeon homolog", "protein_names_refseq": "gamma-secretase-activating protein isoform 1; protein pigeon homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:212167)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20811458;21750661;23209290;26076991;34156424", "class_list": "", "function": "GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease., [RefSeq, PubMed]; Gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation, [RefSeq, PubMed]; Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD., [UniProtKB, PubMed]; Study reports discovery of a novel gamma-secretase activating protein (GSAP) that selectively increases amyloid-beta production through interactions with gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV93;Q8BJR8;Q8BZR8;Q8R1Y4", "ec_number_list": "", "go_molecular_function": "GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005802 trans-Golgi network", "go_biological_process": "GO:1902004 positive regulation of amyloid-beta formation;GO:0030162 regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TCV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TLS3-1", "uniprot_id": "GDPP1_MOUSE", "mass": 42515.0, "length": 386, "protein_name": "GDP-D-glucose phosphorylase 1", "gene_name": "Gdpgp1", "organism": "Mouse", "refseq_name": "GDP-D-glucose phosphorylase 1", "refseq_ac": "NP_848867", "gene_names_uniprotkb": "Gdpgp1", "gene_names_refseq": "D330012F22Rik; Gdpgp1", "protein_names_uniprotkb": "GDP-D-glucose phosphorylase 1; 2.7.7.78", "protein_names_refseq": "GDP-D-glucose phosphorylase 1; GDP-D-glucose phosphorylase C15orf58 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:269952)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21507950;31968056", "class_list": "", "function": "Specific and highly efficient GDP-D-glucose phosphorylase that regulates the levels of GDP-D-glucose in cells (By similarity). Is involved in adaptive response to stress conditions, and plays a key role in neuronal stress resistance by modulating neuronal glycogen levels and maintaining glucose balance (PubMed:31968056)., [UniProtKB, UniProtKB, PubMed]; The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP89;Q8C3L2;Q8C3Y3;Q8CI49", "ec_number_list": "2.7.7.78", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0080048 GDP-D-glucose phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TLS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TR54-1", "uniprot_id": "GSDC4_MOUSE", "mass": 53992.0, "length": 480, "protein_name": "Gasdermin-C4", "gene_name": "Gsdmc4", "organism": "Mouse", "refseq_name": "gasdermin-C4", "refseq_ac": "NP_083268", "gene_names_uniprotkb": "Gsdmc4", "gene_names_refseq": "9030605I04Rik; GsdmC-2; Gsdmc4", "protein_names_uniprotkb": "Gasdermin-C4", "protein_names_refseq": "gasdermin-C4; gasderminC-2", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:74548)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17350798;34012073", "class_list": "", "function": "Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C4 by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis., [UniProtKB, UniProtKB]; This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C4, N-terminal) binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKJ0;Q9D326", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TR54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TYR5-1", "uniprot_id": "GRCR2_MOUSE", "mass": 28601.0, "length": 254, "protein_name": "Glutaredoxin domain-containing cysteine-rich protein 2", "gene_name": "Grxcr2", "organism": "Mouse", "refseq_name": "glutaredoxin domain-containing cysteine-rich protein 2", "refseq_ac": "NP_001028598", "gene_names_uniprotkb": "Grxcr2; Gm851", "gene_names_refseq": "Gm851; Grxcr2", "protein_names_uniprotkb": "Glutaredoxin domain-containing cysteine-rich protein 2; GRXCR1-like protein; Glutaredoxin domain-containing cysteine-rich protein 1-like protein", "protein_names_refseq": "GRXCR1-like protein; glutaredoxin domain-containing cysteine-rich protein 1-like protein; glutaredoxin domain-containing cysteine-rich protein 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 101 (Disease Ontology:DOID:0110462)", "pathway": " (mmu:332309)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30157177;30380417;35752427", "class_list": "", "function": "GRXCR2 plays an intrinsic role in bundle orientation, organization, and sensory function in the inner ear during development and at maturity Publication Status: Online-Only, [RefSeq, PubMed]; Required for hearing (PubMed:30380417). Plays a role in maintaining cochlear stereocilia bundles that are involved in sound detection (PubMed:15489334, PubMed:35752427). Ensures the restriction of TPRN to the basal region of stereocilia in hair cells (PubMed:30380417)., [UniProtKB, PubMed, PubMed]; Stereocilia lacking GRXCR2 are longer than normal and disorganized due to the mislocalization of taperin, which could modulate the actin cytoskeleton in stereocilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYQ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005902 microvillus;GO:0120043 stereocilium shaft;GO:0120044 stereocilium base", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization;GO:0060122 inner ear receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TYR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHH8-1", "uniprot_id": "GXLT1_MOUSE", "mass": 46491.0, "length": 404, "protein_name": "Glucoside xylosyltransferase 1", "gene_name": "Gxylt1", "organism": "Mouse", "refseq_name": "glucoside xylosyltransferase 1 isoform 1", "refseq_ac": "NP_001028447", "gene_names_uniprotkb": "Gxylt1; Glt8d3; Gm87", "gene_names_refseq": "Glt8d3; Gm1228; Gm87; Gxylt1", "protein_names_uniprotkb": "Glucoside xylosyltransferase 1; 2.4.2.42; Glycosyltransferase 8 domain-containing protein 3", "protein_names_refseq": "glucoside xylosyltransferase 1 isoform 1; glycosyltransferase 8 domain containing 3; glycosyltransferase 8 domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:223827)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30899004;32152506", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B7ZWC3", "ec_number_list": "2.4.2.42", "go_molecular_function": "GO:0035252 UDP-xylosyltransferase activity;GO:0140563 UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 7, "hit_score": 1.4, "record_id": "Q3UHH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M8Q2-1", "uniprot_id": "H2AL1_MOUSE", "mass": 12122.0, "length": 105, "protein_name": "Histone H2A-like 1", "gene_name": "H2al1a; H2al1c; H2al1d; H2al1f; H2al1g; H2al1h; H2al1i", "organism": "Mouse", "refseq_name": "histone H2A-like 1", "refseq_ac": "NP_001104507", "gene_names_uniprotkb": "H2al1a; H2al1c; H2al1d; H2al1f; H2al1g; H2al1h; H2al1i", "gene_names_refseq": "Gm14483; H2A.L.1; H2AL1; H2al1a; H2al1c; H2al1d; H2al1f; H2al1g; H2al1h; H2al1i", "protein_names_uniprotkb": "Histone H2A-like 1; H2A.L.1; H2AL1; Histone H2Alike 1", "protein_names_refseq": "histone H2A-like 1; histone H2Alike 1; histone cluster 2 family member", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042922); (mmu:100042929); (mmu:100042931); (mmu:100042939); (mmu:100042943); (mmu:100042944); (mmu:100042946)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "17261847;18703863", "class_list": "", "function": "Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0031507 heterochromatin formation;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M8Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SDA5-1", "uniprot_id": "GUC2F_MOUSE", "mass": 124425.0, "length": 1108, "protein_name": "Retinal guanylyl cyclase 2", "gene_name": "Gucy2f", "organism": "Mouse", "refseq_name": "retinal guanylyl cyclase 2 precursor", "refseq_ac": "NP_001007577", "gene_names_uniprotkb": "Gucy2f", "gene_names_refseq": "A930002I06; GC-F; GC2; Gucy2f", "protein_names_uniprotkb": "Retinal guanylyl cyclase 2; 4.6.1.2; Guanylate cyclase 2F", "protein_names_refseq": "retinal guanylyl cyclase 2 precursor; retinal guanylyl cyclase 2", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:245650); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15718098;17255100;21078983", "class_list": "", "function": "Guanylate cyclase 1 and guanylate cyclase 2 have roles in function of rod and cone photoreceptors, [RefSeq, PubMed]; Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (By similarity). Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (PubMed:17255100)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLL8", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042622 photoreceptor outer segment membrane;GO:0120200 rod photoreceptor outer segment;GO:0120202 rod photoreceptor disc membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5SDA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61858-1", "uniprot_id": "GPAN1_MOUSE", "mass": 41011.0, "length": 372, "protein_name": "G patch domain and ankyrin repeat-containing protein 1", "gene_name": "Gpank1", "organism": "Mouse", "refseq_name": "G patch domain and ankyrin repeat-containing protein 1 isoform 2", "refseq_ac": "NP_001122069", "gene_names_uniprotkb": "Gpank1; Bat-4; Bat4; G5", "gene_names_refseq": "Bat-4; Bat4; D17H6S54E; G5; Gpank1", "protein_names_uniprotkb": "G patch domain and ankyrin repeat-containing protein 1; G5 protein; HLA-B-associated transcript 4", "protein_names_refseq": "G patch domain and ankyrin repeat-containing protein 1 isoform 2; G patch domain and ankyrin repeat-containing protein 1; G patch domain and ankyrin repeats-containing protein 1; HLA-B associated transcript 4; protein BAT4", "tax_id": 10090, "disease": "", "pathway": " (mmu:81845)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14656967;21750661;31219806;9196000", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBG8;Q9R065", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61858-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64516-3", "uniprot_id": "GLPK_MOUSE", "mass": 61227.0, "length": 559, "protein_name": "Glycerol kinase", "gene_name": "Gk", "organism": "Mouse", "refseq_name": "glycerol kinase isoform 4", "refseq_ac": "NP_001281069", "gene_names_uniprotkb": "Gk; Gyk", "gene_names_refseq": "D930012N15Rik; Gk; Gyk", "protein_names_uniprotkb": "Glycerol kinase; 2.7.1.30; ATP:glycerol 3-phosphotransferase; Glycerokinase", "protein_names_refseq": "ATP:glycerol 3-phosphotransferase; glycerokinase; glycerol kinase isoform 4", "tax_id": 10090, "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363); familial hypercholesterolemia (Disease Ontology:DOID:13810)", "pathway": " (mmu:14933); (R-MMU-75109)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15845384;31219806;32273338;33300544;34428180;34551152;8884278", "class_list": "", "function": "Deletion of pleiotrophin impairs glucose tolerance and liver metabolism in pregnant mice: Moonlighting role of glycerol kinase., [RefSeq, PubMed]; Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes., [RefSeq, PubMed]; Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASZ1;Q8C2M1;Q8C8X0", "ec_number_list": "2.7.1.30", "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0045471 response to ethanol;GO:0019217 regulation of fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64516-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68EF4-1", "uniprot_id": "GRM4_MOUSE", "mass": 101824.0, "length": 912, "protein_name": "Metabotropic glutamate receptor 4", "gene_name": "Grm4", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 4 isoform 2 precursor", "refseq_ac": "NP_001013403", "gene_names_uniprotkb": "Grm4; Gprc1d; Mglur4", "gene_names_refseq": "Gprc1d; Grm4; mGluR4", "protein_names_uniprotkb": "Metabotropic glutamate receptor 4; mGluR4", "protein_names_refseq": "G protein-coupled receptor GRM4; G protein-coupled receptor, family C, group 1, member D; metabotropic glutamate receptor 4 isoform 2 precursor; metabotropic glutamate receptor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:268934); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12679517;21750661;30899004;33300544;37029391", "class_list": "", "function": "G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity)., [UniProtKB]; The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80UC2", "ec_number_list": "", "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding;GO:0001642 group III metabotropic glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043195 terminal bouton;GO:0043198 dendritic shaft", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007612 learning;GO:0043410 positive regulation of MAPK cascade;GO:0007268 chemical synaptic transmission;GO:0051966 regulation of synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q68EF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDE7-1", "uniprot_id": "GGT6_MOUSE", "mass": 51467.0, "length": 497, "protein_name": "Glutathione hydrolase 6", "gene_name": "Ggt6", "organism": "Mouse", "refseq_name": "glutathione hydrolase 6 isoform 1", "refseq_ac": "NP_082095", "gene_names_uniprotkb": "Ggt6", "gene_names_refseq": "9030405D14Rik; Ggt6", "protein_names_uniprotkb": "Glutathione hydrolase 6; 2.3.2.2; 3.4.19.13; GGT 6; Gamma-glutamyltransferase 6; Gamma-glutamyltranspeptidase 6", "protein_names_refseq": "GGT 6; gamma-glutamyltranspeptidase 6; glutathione hydrolase 6 isoform 1; glutathione hydrolase 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:71522); (R-MMU-174403); (R-MMU-5423646); (R-MMU-9753281)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5F245;Q9D347", "ec_number_list": "2.3.2.2;3.4.19.13;3.4.19.14", "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PDE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6YNI2-1", "uniprot_id": "GPR6_MOUSE", "mass": 38085.0, "length": 363, "protein_name": "G protein-coupled receptor 6", "gene_name": "Gpr6", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 6", "refseq_ac": "NP_951013", "gene_names_uniprotkb": "Gpr6; Gm233", "gene_names_refseq": "Gm233; Gpr6", "protein_names_uniprotkb": "G protein-coupled receptor 6; Sphingosine 1-phosphate receptor GPR6", "protein_names_refseq": "G-protein coupled receptor 6; sphingosine 1-phosphate receptor GPR6", "tax_id": 10090, "disease": "", "pathway": " (mmu:140741)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14592418;17284443;17934457;24747358", "class_list": "", "function": "Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes including neuronal development, through activation of intracellular signaling pathways via G(s) (PubMed:17284443). May be activated by lipid-derived agonists such as oleic acid or sphingosine 1-phosphate, leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed:24747358)., [UniProtKB, PubMed, PubMed]; Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal., [RefSeq, PubMed]; Identification, characterization and cloning; identified sphingosine-1-phosphate as a high-affinity ligand, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6YNI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQC7-1", "uniprot_id": "GPTC2_MOUSE", "mass": 58218.0, "length": 527, "protein_name": "G patch domain-containing protein 2", "gene_name": "Gpatch2", "organism": "Mouse", "refseq_name": "G patch domain-containing protein 2 isoform 1", "refseq_ac": "NP_080643", "gene_names_uniprotkb": "Gpatch2; Gpatc2", "gene_names_refseq": "5830433G22Rik; 5830436K05Rik; Gpatc2; Gpatch2", "protein_names_uniprotkb": "G patch domain-containing protein 2", "protein_names_refseq": "G patch domain-containing protein 2 isoform 1; g patch domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67769)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;36973252", "class_list": "", "function": "Deletion of Gpatch2 does not alter Tnf expression in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Enhances the ATPase activity of DHX15 in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNJ9;Q8BPM1;Q8CDH9", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TQC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQP2-1", "uniprot_id": "GP135_MOUSE", "mass": 49361.0, "length": 457, "protein_name": "G protein-coupled receptor 135", "gene_name": "Gpr135", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 135", "refseq_ac": "NP_861417", "gene_names_uniprotkb": "Gpr135", "gene_names_refseq": "Gpr135; PAFR", "protein_names_uniprotkb": "G protein-coupled receptor 135", "protein_names_refseq": "G-protein coupled receptor 135; probable G-protein coupled receptor 135", "tax_id": 10090, "disease": "", "pathway": " (mmu:238252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14623098", "class_list": "", "function": "Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQP3-1", "uniprot_id": "GP119_MOUSE", "mass": 36995.0, "length": 335, "protein_name": "Glucose-dependent insulinotropic receptor", "gene_name": "Gpr119", "organism": "Mouse", "refseq_name": "glucose-dependent insulinotropic receptor", "refseq_ac": "NP_861416", "gene_names_uniprotkb": "Gpr119", "gene_names_refseq": "Gpr119", "protein_names_uniprotkb": "Glucose-dependent insulinotropic receptor; G protein-coupled receptor 119", "protein_names_refseq": "glucose-dependent insulinotropic receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:236781); (R-MMU-381771); (R-MMU-400511)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14623098;15607732;16517404;17070774;17289847", "class_list": "", "function": "AR231453 also enhanced glucose-dependent insulin release in vivo and improved oral glucose tolerance in wild-type mice but not in GPR119-deficient mice. Erratum:[Endocrinology. 2007 Oct;148(10):4753], [RefSeq, PubMed]; GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders., [RefSeq, PubMed]; Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway., [UniProtKB, PubMed]; The Gpr119 mRNA levels were elevated in islets of obese hyperglycemic db/db mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2ABS2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0030073 insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TQP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T62-1", "uniprot_id": "GP101_MOUSE", "mass": 56245.0, "length": 511, "protein_name": "Probable G protein-coupled receptor 101", "gene_name": "Gpr101", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 101", "refseq_ac": "NP_001028532", "gene_names_uniprotkb": "Gpr101; Gm365", "gene_names_refseq": "GPCR6; Gm365; Gpr101", "protein_names_uniprotkb": "Probable G protein-coupled receptor 101", "protein_names_refseq": "G protein-coupled receptor GPR101; probable G-protein coupled receptor 101", "tax_id": 10090, "disease": "growth hormone secreting pituitary adenoma 2 (Disease Ontology:DOID:0112007)", "pathway": " (mmu:245424)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12679517;16647048;25470569;31793912;36400250", "class_list": "", "function": "Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation., [RefSeq, PubMed]; Findings demonstrate a fundamental role for GPR101 in mediating the leukocyte-directed actions of RvD5n-3 DPA., [RefSeq, PubMed]; Murine Gpr101 mRNA was detected predominantly in the brain within discrete nuclei and that GPR101 participates in a potentially wide range of activities in the CNS via modulation of cAMP levels., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUI9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80T62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810K9-1", "uniprot_id": "GXLT2_MOUSE", "mass": 51479.0, "length": 444, "protein_name": "Glucoside xylosyltransferase 2", "gene_name": "Gxylt2", "organism": "Mouse", "refseq_name": "glucoside xylosyltransferase 2", "refseq_ac": "NP_941014", "gene_names_uniprotkb": "Gxylt2; Glt8d4", "gene_names_refseq": "Glt8d4; Gm152; Gxylt2", "protein_names_uniprotkb": "Glucoside xylosyltransferase 2; 2.4.2.42; Glycosyltransferase 8 domain-containing protein 4", "protein_names_refseq": "glucoside xylosyltransferase 2; glycosyltransferase 8 domain containing 4; glycosyltransferase 8 domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:232313)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.42", "go_molecular_function": "GO:0035252 UDP-xylosyltransferase activity;GO:0140563 UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 7, "hit_score": 0.2, "record_id": "Q810K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGR8-1", "uniprot_id": "GSKIP_MOUSE", "mass": 15642.0, "length": 139, "protein_name": "GSK3B-interacting protein", "gene_name": "Gskip", "organism": "Mouse", "refseq_name": "GSK3B-interacting protein", "refseq_ac": "NP_848728", "gene_names_uniprotkb": "Gskip", "gene_names_refseq": "4933433P14Rik; Gskip", "protein_names_uniprotkb": "GSK3B-interacting protein; GSKIP", "protein_names_refseq": "GSK3-beta interaction protein; GSK3B-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66787)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26582204;32828530;34748402", "class_list": "", "function": "A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (PubMed:26582204)., [UniProtKB, UniProtKB, PubMed]; GSKIP protects cardiomyocytes from hypoxia/reoxygenation-induced injury by enhancing Nrf2 activation via GSK-3beta inhibition., [RefSeq, PubMed]; Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size., [RefSeq, PubMed]; These findings reveal a novel, crucial role for GSKIP in the coordination of GSK3beta signaling in palatal shelf fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDW3;Q8K2G9", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0034237 protein kinase A regulatory subunit binding;GO:0051018 protein kinase A binding;GO:0019207 kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006469 negative regulation of protein kinase activity;GO:0030111 regulation of Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIY1-1", "uniprot_id": "GPTC3_MOUSE", "mass": 59180.0, "length": 525, "protein_name": "G patch domain-containing protein 3", "gene_name": "Gpatch3", "organism": "Mouse", "refseq_name": "G patch domain-containing protein 3", "refseq_ac": "NP_766464", "gene_names_uniprotkb": "Gpatch3; Gpatc3", "gene_names_refseq": "D930035B09Rik; Gpatc3; Gpatch3", "protein_names_uniprotkb": "G patch domain-containing protein 3", "protein_names_refseq": "G patch domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:242691)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Involved in transcriptional regulation. It is able to activate transcription from CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9E8", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0039536 negative regulation of RIG-I signaling pathway;GO:0032480 negative regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BIY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTZ7-1", "uniprot_id": "GMPPB_MOUSE", "mass": 39917.0, "length": 360, "protein_name": "Mannose-1-phosphate guanylyltransferase catalytic subunit beta", "gene_name": "Gmppb", "organism": "Mouse", "refseq_name": "mannose-1-phosphate guanylyltransferase catalytic subunit beta", "refseq_ac": "NP_808578", "gene_names_uniprotkb": "Gmppb", "gene_names_refseq": "E430010H19; Gmppb", "protein_names_uniprotkb": "Mannose-1-phosphate guanylyltransferase catalytic subunit beta; 2.7.7.13; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta", "protein_names_refseq": "GTP-mannose-1-phosphate guanylyltransferase beta; mannose-1-phosphate guanyltransferase beta; mannose-1-phosphate guanylyltransferase catalytic subunit beta", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2T (Disease Ontology:DOID:0110294); congenital muscular dystrophy-dystroglycanopathy type A14 (Disease Ontology:DOID:0111233); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B14 (Disease Ontology:DOID:0112377)", "pathway": " (mmu:331026); (R-MMU-446205)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26495903", "class_list": "glycogene", "function": "Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex (By similarity). Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids (By similarity). Can catalyze the reverse reaction in vitro (By similarity). Together with GMPPA regulates GDP-alpha-D-mannose levels (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.13", "go_molecular_function": "GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0120508 GDP-mannose pyrophosphorylase complex", "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BTZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUV8-1", "uniprot_id": "GP107_MOUSE", "mass": 62056.0, "length": 551, "protein_name": "Protein GPR107", "gene_name": "Gpr107", "organism": "Mouse", "refseq_name": "protein GPR107 precursor", "refseq_ac": "NP_848875", "gene_names_uniprotkb": "Gpr107; Kiaa1624", "gene_names_refseq": "9930033D15Rik; C530034M11; Gpr107; mKIAA1624", "protein_names_uniprotkb": "Protein GPR107", "protein_names_refseq": "protein GPR107 precursor; protein GPR107", "tax_id": 10090, "disease": "", "pathway": " (mmu:277463)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;22933024;24849652;26561648;34428180", "class_list": "", "function": "GPR107 interacts directly or indirectly with a limited subset of surface receptors., [RefSeq, PubMed]; GPR107 is a promising candidate receptor for neuronostatin, and neuronostatin, interacting with GPR107, may play an important role in the central control of cardiovascular function., [RefSeq, PubMed]; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity)., [UniProtKB, UniProtKB]; Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPL4;Q8BM58;Q8BMN6;Q8BTW1", "ec_number_list": "", "go_molecular_function": "GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BUV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVG5-1", "uniprot_id": "GLT14_MOUSE", "mass": 63989.0, "length": 550, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 14", "gene_name": "Galnt14", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 14", "refseq_ac": "NP_082140", "gene_names_uniprotkb": "Galnt14", "gene_names_refseq": "0610033M06Rik; Galnt14", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 14; 2.4.1.41; GalNAc-T14; Polypeptide GalNAc transferase 14; Protein-UDP acetylgalactosaminyltransferase 14; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14; pp-GaNTase 14", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14; galNAc-T14; polypeptide GalNAc transferase 14; polypeptide N-acetylgalactosaminyltransferase 14; pp-GaNTase 14; protein-UDP acetylgalactosaminyltransferase 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:71685); (R-MMU-913709)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22872234;34203471;34428180;38763428", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney (By similarity)., [UniProtKB]; Polypeptide N-Acetylgalactosaminyl transferase 14 is a novel mediator in pancreatic beta-cell function and growth. Erratum:[Mol Cell Endocrinol. 2024 Sep 15;591:112291. doi: 10.1016/j.mce.2024.112291. PMID: 38838620], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60GT2;Q8BTI6;Q9DCJ2", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.5, "record_id": "Q8BVG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX05-1", "uniprot_id": "GLPK5_MOUSE", "mass": 59812.0, "length": 534, "protein_name": "Glycerol kinase 5", "gene_name": "Gk5", "organism": "Mouse", "refseq_name": "glycerol kinase 5 isoform 2", "refseq_ac": "NP_796326", "gene_names_uniprotkb": "Gk5", "gene_names_refseq": "C330018K18Rik; G630067D24Rik; Gk5", "protein_names_uniprotkb": "Glycerol kinase 5; 2.7.1.30; ATP:glycerol 3-phosphotransferase 5; GK 5; Glycerokinase 5", "protein_names_refseq": "ATP:glycerol 3-phosphotransferase 5; GK 5; glycerokinase 5; glycerol kinase 5 (putative); glycerol kinase 5 isoform 2; putative glycerol kinase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:235533)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28607088;31219806", "class_list": "", "function": "GK5 formed a complex with the sterol regulatory element-binding proteins (SREBPs) through their C-terminal regulatory domains, inhibiting SREBP processing and activation., [RefSeq, PubMed]; Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14B67;Q3TK02;Q3TSE0;Q80VA9", "ec_number_list": "2.7.1.30", "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BX05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZM1-1", "uniprot_id": "GLMN_MOUSE", "mass": 67756.0, "length": 596, "protein_name": "Glomulin", "gene_name": "Glmn", "organism": "Mouse", "refseq_name": "glomulin isoform a", "refseq_ac": "NP_001155210", "gene_names_uniprotkb": "Glmn; Fap48", "gene_names_refseq": "9330160J16Rik; Fap48; Fap68; Glmn", "protein_names_uniprotkb": "Glomulin; FAP; FK506-binding protein-associated protein; FKBP-associated protein", "protein_names_refseq": "FAP; FK506-binding protein-associated protein; FKBP-associated protein; glomulin isoform a", "tax_id": 10090, "disease": "arteriovenous malformation (Disease Ontology:DOID:11294); glomus tumor (Disease Ontology:DOID:2431); glomangioma (Disease Ontology:DOID:2436)", "pathway": " (mmu:170823); (R-MMU-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15053987;21750661;22405651;25246571;29191979;34428180", "class_list": "", "function": "Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1 (By similarity). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (PubMed:22405651). Essential for normal development of the vasculature (PubMed:22405651). Contributes to the regulation of RPS6KB1 phosphorylation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase and glomulin (GLMN)., [RefSeq, PubMed]; Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation., [RefSeq, PubMed]; The glomulin expression during murine development (E9.5 days post-coitum until adulthood) by non-radioactive in situ hybridization was studied., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFR5;Q99LB8", "ec_number_list": "", "go_molecular_function": "GO:0005171 hepatocyte growth factor receptor binding;GO:0005102 signaling receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0055105 ubiquitin-protein transferase inhibitor activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0031461 cullin-RING ubiquitin ligase complex", "go_biological_process": "GO:0072359 circulatory system development;GO:0001570 vasculogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BZM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C010-1", "uniprot_id": "GPR61_MOUSE", "mass": 49382.0, "length": 449, "protein_name": "G protein-coupled receptor 61", "gene_name": "Gpr61", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 61", "refseq_ac": "NP_001292390", "gene_names_uniprotkb": "Gpr61", "gene_names_refseq": "Gpr61", "protein_names_uniprotkb": "G protein-coupled receptor 61", "protein_names_refseq": "G-protein coupled receptor 61", "tax_id": 10090, "disease": "", "pathway": " (mmu:229714)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21971119;28912303", "class_list": "", "function": "Orphan G protein-coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). May be involved in the regulation of food intake and body weight (PubMed:21971119)., [UniProtKB, UniProtKB, PubMed]; These findings suggest that GPR61 is involved in the regulation of food intake and body weight, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZR6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0010008 endosome membrane", "go_biological_process": "GO:0038035 ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0P0-1", "uniprot_id": "GWL_MOUSE", "mass": 95975.0, "length": 865, "protein_name": "Serine/threonine-protein kinase greatwall", "gene_name": "Mastl", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase greatwall", "refseq_ac": "NP_080255", "gene_names_uniprotkb": "Mastl; Gwl; Gw", "gene_names_refseq": "2700091H24Rik; GWL; GW; MAST-L; Mastl; THC2", "protein_names_uniprotkb": "Serine/threonine-protein kinase greatwall; 2.7.11.1; GWL; GW; MAST-L; Microtubule-associated serine/threonine-protein kinase-like", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase-like; serine/threonine-protein kinase greatwall", "tax_id": 10090, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": " (mmu:67121); (R-MMU-2465910)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "21156286;24101512;25246615;25428506;27631493;28528544;30252678;30293837;32978522;34428180;35820727;36354735", "class_list": "", "function": "Data show that Mastl (Greatwall)-null cells display mitotic collapse after nuclear envelope breakdown (NEB) characterized by defective chromosome condensation and prometaphase arrest., [RefSeq, PubMed]; Findings reveal the role of RSK in mouse oocytes, showing that the RSK-MASTL pathway allows mammalian-specific prolonged meiotic exit and ensures the faithful conversion from sperm to paternal pronuclei., [RefSeq, PubMed]; Mastl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 activity., [RefSeq, PubMed]; Reveal an unexpected role of Mastl in actin cytoskeletal dynamics in postmitotic cells and suggest that the thrombocytopenia-associated mutation in MASTL is a pathogenic dominant mutation that mimics decreased PP2A activity resulting in altered phosphorylation of cytoskeletal regulatory pathways., [RefSeq, PubMed]; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:21156286). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (By similarity). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (By similarity). Following DNA damage, it is also involved in checkpoint recovery by being inhibited., [UniProtKB, PubMed, UniProtKB]; The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis., [RefSeq, PubMed]; The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner., [RefSeq, PubMed]; Using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 pathway in preventing premature SAC silencing Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQY2;Q3MIA9;Q5RJW0;Q6NXX9;Q8BVF3;Q9CZH9;Q9D9V0", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0044325 transmembrane transporter binding;GO:0051721 protein phosphatase 2A binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0032154 cleavage furrow", "go_biological_process": "GO:0007147 female meiosis II;GO:0000278 mitotic cell cycle;GO:0035556 intracellular signal transduction;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8C0P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB12-1", "uniprot_id": "GSDC3_MOUSE", "mass": 54188.0, "length": 480, "protein_name": "Gasdermin-C3", "gene_name": "Gsdmc3", "organism": "Mouse", "refseq_name": "gasdermin-C3", "refseq_ac": "NP_899017", "gene_names_uniprotkb": "Gsdmc3", "gene_names_refseq": "9930109F21Rik; Gsdmc3", "protein_names_uniprotkb": "Gasdermin-C3", "protein_names_refseq": "gasdermin-C3", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:270328)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17350798", "class_list": "", "function": "Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C3 by caspase CASP8 in response to death signals (By similarity). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity)., [UniProtKB, UniProtKB]; This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C3, N-terminal) binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJY6", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CB12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K297-1", "uniprot_id": "GT251_MOUSE", "mass": 71061.0, "length": 617, "protein_name": "Procollagen galactosyltransferase 1", "gene_name": "Colgalt1", "organism": "Mouse", "refseq_name": "procollagen galactosyltransferase 1 isoform 1 precursor", "refseq_ac": "NP_666323", "gene_names_uniprotkb": "Colgalt1; Glt25d1", "gene_names_refseq": "2810024B22Rik; Colgalt1; Glt25d1", "protein_names_uniprotkb": "Procollagen galactosyltransferase 1; 2.4.1.50; Collagen beta(1-O)galactosyltransferase 1; Glycosyltransferase 25 family member 1; Hydroxylysine galactosyltransferase 1", "protein_names_refseq": "glycosyltransferase 25 domain containing 1; glycosyltransferase 25 family member 1; hydroxylysine galactosyltransferase 1; procollagen galactosyltransferase 1 isoform 1 precursor; procollagen galactosyltransferase 1", "tax_id": 10090, "disease": "brain small vessel disease 3 (Disease Ontology:DOID:0112315)", "pathway": " (mmu:234407); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;19349973;25428506;26740625;29187734;30084848;30132521;30899004;31101663;31726007;31759980;33649389;34428180;35820727;37828378;40997131", "class_list": "glycogene;glycosyltransferase", "function": "Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV., [UniProtKB, UniProtKB]; Colgalt1 mutant could serve as a model of a human connective tissue disorder and/or congenital muscular dystrophy or myopathy. Publication Status: Online-Only, [RefSeq, PubMed]; GLT25D1 catalyzes galactosylation of Hyl throughout the type I collagen molecule and that this modification may regulate maturation of collagen cross-linking, fibrillogenesis, and mineralization, [RefSeq, PubMed]; Results demonstrate that Glt25d1 knockout results in embryonic lethality and down-regulation of Glt25d1 may inhibit collagen secretion during liver fibrogenesis., [RefSeq, PubMed]; The downregulation of Glt25d1 deteriorated CCl4induced liver injury in mice, which may involve triggering inflammatory responses, apoptosis and TGFbeta1/Smad2 signaling pathway activation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3R5;Q6PGL1", "ec_number_list": "2.4.1.50;1.14.11.4;2.4.1.66", "go_molecular_function": "GO:0050211 procollagen galactosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:1904028 positive regulation of collagen fibril organization;GO:0180062 protein O-linked glycosylation via galactose", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8K297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2Q2-1", "uniprot_id": "GSTO2_MOUSE", "mass": 28599.0, "length": 248, "protein_name": "Glutathione S-transferase omega-2", "gene_name": "Gsto2", "organism": "Mouse", "refseq_name": "glutathione S-transferase omega-2", "refseq_ac": "NP_080895", "gene_names_uniprotkb": "Gsto2", "gene_names_refseq": "1700020F09Rik; 4930425C18Rik; GSTO 2-2; Gsto2", "protein_names_uniprotkb": "Glutathione S-transferase omega-2; 1.20.4.2; 1.8.5.1; 2.5.1.18; GSTO 2-2; GSTO-2; Glutathione S-transferase omega 2-2; Glutathione-dependent dehydroascorbate reductase; MMA(V) reductase; Monomethylarsonic acid reductase", "protein_names_refseq": "GSTO-2; MMA(V) reductase; glutathione S-transferase omega 2-2; glutathione S-transferase omega-2; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 6 (Disease Ontology:DOID:0060198); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:68214); (R-MMU-156590); (R-MMU-196836)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;29036365;31087045;38386166", "class_list": "", "function": "Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GSTO2 is transported and deposited in the postacrosomal sheath (PAS) region by the manchette, and that the late assembly of GSTO2 and its localization in the PAS suggests a role in regulating the oxidative and reductive state of covalently linked spermatid/sperm proteins, especially during the disassembly of the sperm accessory structures after fertilization, [RefSeq, PubMed]; Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage. Publication Status: Online-Only, [RefSeq, PubMed]; Sperm-borne glutathione-S-transferase omega 2 accelerates the nuclear decondensation of spermatozoa during fertilization in micedagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2;1.8.-.-", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity;GO:0050610 methylarsonate reductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019852 L-ascorbic acid metabolic process;GO:0071243 cellular response to arsenic-containing substance;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K2Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R088-1", "uniprot_id": "GLP3L_MOUSE", "mass": 32906.0, "length": 285, "protein_name": "Golgi phosphoprotein 3-like", "gene_name": "Golph3l", "organism": "Mouse", "refseq_name": "Golgi phosphoprotein 3-like isoform 2", "refseq_ac": "NP_001171140", "gene_names_uniprotkb": "Golph3l", "gene_names_refseq": "2010204I15Rik; Golph3l; Gpp34r", "protein_names_uniprotkb": "Golgi phosphoprotein 3-like", "protein_names_refseq": "Golgi phosphoprotein 3-like isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:229593)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23345592", "class_list": "", "function": "Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIX2;Q3TV24", "ec_number_list": "", "go_molecular_function": "GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0140312 cargo adaptor activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0043001 Golgi to plasma membrane protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization;GO:0048194 Golgi vesicle budding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1W2-1", "uniprot_id": "GSG1_MOUSE", "mass": 36108.0, "length": 324, "protein_name": "Germ cell-specific gene 1 protein", "gene_name": "Gsg1", "organism": "Mouse", "refseq_name": "germ cell-specific gene 1 protein isoform a", "refseq_ac": "NP_001074021", "gene_names_uniprotkb": "Gsg1", "gene_names_refseq": "Gsg1", "protein_names_uniprotkb": "Germ cell-specific gene 1 protein; Germ cell-associated protein 1", "protein_names_refseq": "germ cell-associated protein 1; germ cell-specific gene 1 protein isoform a; germ cell-specific gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14840)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18325338;21750661;30779550;7957958;9337410", "class_list": "", "function": "Expression of GSG1 stimulates TPAP targeting to the ER, suggesting that interactions between the two proteins lead to the redistribution of TPAP from the cytosol to the ER, [RefSeq, PubMed]; May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2N5;Q9D9Z3;Q9Z1H7", "ec_number_list": "", "go_molecular_function": "GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R1W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHD6-1", "uniprot_id": "GTR10_MOUSE", "mass": 56579.0, "length": 536, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 10", "gene_name": "Slc2a10", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 10", "refseq_ac": "NP_569718", "gene_names_uniprotkb": "Slc2a10; Glut10", "gene_names_refseq": "Glut10; Slc2a10", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 10; GLUT-10; Glucose transporter type 10", "protein_names_refseq": "glucose transporter type 10; solute carrier family 2, facilitated glucose transporter member 10", "tax_id": 10090, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645)", "pathway": " (mmu:170441); (R-MMU-189200)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11592815;12890477;18693279;20639396;31219806;37170065;37220836", "class_list": "glycogene", "function": "Expression in adipose tissue, [RefSeq, PubMed]; Facilitative glucose transporter required for the development of the cardiovascular system., [UniProtKB, UniProtKB]; GLUT10 protects cells from oxidative injury., [RefSeq, PubMed]; Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function., [RefSeq, PubMed]; Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice., [RefSeq, PubMed]; Report that two mouse models, homozygous respectively for G128E and S150F missense substitutions in glut10 do not present any of the vascular, anatomical, or immunohistological abnormalities as encountered in human Arterial tortuosity syndrome patients., [RefSeq, PubMed]; This gene encodes a class III facilitative glucose transporter. Mutations in the related gene in human are associated with arterial tortuosity syndrome. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:0072359 circulatory system development;GO:1904659 D-glucose transmembrane transport;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VHD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L27-1", "uniprot_id": "GMPR2_MOUSE", "mass": 38019.0, "length": 348, "protein_name": "GMP reductase 2", "gene_name": "Gmpr2", "organism": "Mouse", "refseq_name": "GMP reductase 2", "refseq_ac": "NP_818773", "gene_names_uniprotkb": "Gmpr2", "gene_names_refseq": "1810008P16Rik; 5730544D12Rik; GMPR 2; Gmpr2", "protein_names_uniprotkb": "GMP reductase 2; 1.7.1.7; GMPR 2; Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2", "protein_names_refseq": "GMP reductase 2; guanosine 5'-monophosphate oxidoreductase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:105446); (R-MMU-74217)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity)., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542X2;Q8R1T5", "ec_number_list": "1.7.1.7", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003920 GMP reductase activity", "go_cellular_component": "GO:1902560 GMP reductase complex", "go_biological_process": "GO:0046037 GMP metabolic process;GO:0032264 IMP salvage;GO:0006144 purine nucleobase metabolic process;GO:0030224 monocyte differentiation;GO:0046038 GMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99L27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N64-1", "uniprot_id": "GMCL2_MOUSE", "mass": 57827.0, "length": 498, "protein_name": "Germ cell-less protein-like 2", "gene_name": "Btbd35f1; Gmcl2", "organism": "Mouse", "refseq_name": "germ cell-less protein-like 2", "refseq_ac": "NP_001161809", "gene_names_uniprotkb": "Btbd35f1; Gmcl2; Btbd35f1; Gmcl1l; Gmcl1p1", "gene_names_refseq": "100040533; Btbd35f5; GMCL1P1; Gclh; Gm2825; Gmcl1l; Gmcl2", "protein_names_uniprotkb": "Germ cell-less protein-like 2; BTB domain containing 35, family member 1; Germ cell-less protein-like 1-like; mGclh", "protein_names_refseq": "BTB domain containing 35, family member 1; germ cell-less protein-like 2; mGclh", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040533); (mmu:100861966); (mmu:100862329); (mmu:71847)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Possible function in spermatogenesis. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJS3;Q99N65;Q99N66;Q9DA87", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016363 nuclear matrix", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016567 protein ubiquitination;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99N64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQI3-1", "uniprot_id": "GMFB_MOUSE", "mass": 16723.0, "length": 142, "protein_name": "Glia maturation factor beta", "gene_name": "Gmfb", "organism": "Mouse", "refseq_name": "glia maturation factor beta", "refseq_ac": "NP_071306", "gene_names_uniprotkb": "Gmfb", "gene_names_refseq": "3110001H22Rik; 3110001O16Rik; D14Ertd630e; Gmfb", "protein_names_uniprotkb": "Glia maturation factor beta; GMF-beta", "protein_names_refseq": "GMF-beta; glia maturation factor beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:63985)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11435704;12697657;12791701;19768801;21750661;31219806;32200671;32737763;35953024;37307824", "class_list": "", "function": "G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury., [RefSeq, PubMed]; Glia Maturation Factor-beta Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals., [RefSeq, PubMed]; Neuroinflammation Mediated by Glia Maturation Factor Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain Injury., [RefSeq, PubMed]; Proteinuria induction of GMF-beta in renal proximal tubular cells may play a critical role in the progression of renal diseases by enhancing oxidative injuries, [RefSeq, PubMed]; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQX5;Q9ERL8", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008083 growth factor activity;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0030864 cortical actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071944 cell periphery", "go_biological_process": "GO:0071846 actin filament debranching;GO:0007612 learning;GO:0007626 locomotory behavior;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQQ4-1", "uniprot_id": "GEMI2_MOUSE", "mass": 30441.0, "length": 269, "protein_name": "Gem-associated protein 2", "gene_name": "Gemin2", "organism": "Mouse", "refseq_name": "gem-associated protein 2", "refseq_ac": "NP_079932", "gene_names_uniprotkb": "Gemin2; Sip1", "gene_names_refseq": "Gemin2; Sip1; gemin-2", "protein_names_uniprotkb": "Gem-associated protein 2; Component of gems 2; Gemin-2; SMN-interacting protein 1; Survival of motor neuron protein-interacting protein 1", "protein_names_refseq": "SMN-interacting protein 1; component of gems 2; gem-associated protein 2; survival of motor neuron protein-interacting protein 1; survivor of motor neuron protein interacting protein 1", "tax_id": 10090, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377)", "pathway": " (mmu:66603); (R-MMU-191859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12091709;20620147;35820727", "class_list": "", "function": "Gene targeting in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death (gemin2; SMN interacting protein 1), [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity)., [UniProtKB, UniProtKB]; This gene encodes one of the proteins found in the survival of motor neuron (SMN) complex, which consists of the SMN protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal small nuclear ribonucleoproteins (snRNP) and for pre-mRNA splicing. This protein interacts directly with the SMN protein and it is required for formation of the SMN complex. Disruption of this gene in mouse resulted in impaired snRNP assembly, and motor neuron degeneration. [provided by RefSeq, Sep 2015]., [RefSeq]; Utilised a targeted screen to identify mRNA associated with SMN, Gemin2 and Gemin3 in the cytoplasm of a human neuroblastoma cell line, SHSY5Y, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAD7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000245 spliceosomal complex assembly;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR60-1", "uniprot_id": "GOT1B_MOUSE", "mass": 15422.0, "length": 138, "protein_name": "Vesicle transport protein GOT1B", "gene_name": "Golt1b", "organism": "Mouse", "refseq_name": "vesicle transport protein GOT1B isoform 3", "refseq_ac": "NP_080148", "gene_names_uniprotkb": "Golt1b", "gene_names_refseq": "2310061A22Rik; CGI-141; Golt1b", "protein_names_uniprotkb": "Vesicle transport protein GOT1B; Golgi transport 1 homolog B", "protein_names_refseq": "vesicle transport protein GOT1B isoform 3; vesicle transport protein GOT1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66964)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in fusion of ER-derived transport vesicles with the Golgi complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CR60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWD0-1", "uniprot_id": "GTSFL_MOUSE", "mass": 17282.0, "length": 151, "protein_name": "Gametocyte-specific factor 1-like", "gene_name": "Gtsf1l", "organism": "Mouse", "refseq_name": "gametocyte-specific factor 1-like", "refseq_ac": "NP_080906", "gene_names_uniprotkb": "Gtsf1l; Fam112a", "gene_names_refseq": "2410116G06Rik; Gtsf1l", "protein_names_uniprotkb": "Gametocyte-specific factor 1-like; Protein FAM112A", "protein_names_refseq": "gametocyte-specific factor 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:68236)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26930067", "class_list": "", "function": "Data show that gametocyte specific factor 1-like Gtsf1l and Gtsf2 (BC048502) protein were sequentially but not simultaneously expressed in gonocytes and spermatids. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVG1;Q9D2S8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESM6-1", "uniprot_id": "GDE3_MOUSE", "mass": 61165.0, "length": 539, "protein_name": "Glycerophosphodiester phosphodiesterase 3", "gene_name": "Gdpd2", "organism": "Mouse", "refseq_name": "glycerophosphoinositol inositolphosphodiesterase GDPD2", "refseq_ac": "NP_001292870", "gene_names_uniprotkb": "Gdpd2; Gde3; Obdpf", "gene_names_refseq": "9130017L10Rik; Gde3; Gdpd2; Obdpf", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 3; 3.1.4.-; 3.1.4.43; Glycerophosphodiester phosphodiesterase domain-containing protein 2; Glycerophosphoinositol inositolphosphodiesterase; Lysophosphatidylinositol-specific ectophospholipase C; Osteoblast differentiation promoting factor", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 3; glycerophosphoinositol inositolphosphodiesterase GDPD2; osteoblast differentiation promoting factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71584)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12933806;15276213;19596859;26740625;28849762;32629025;32917725;34428180;37078963", "class_list": "", "function": "Calcium-dependent ecto-phospholipase C that cleaves the phosphodiester bond between the glycerol backbone and phosphate group of glycerophospholipids at the cell surface, regulating multiple signaling pathways (PubMed:19596859, PubMed:32629025, PubMed:32917725). Substrates include GPI-anchored proteins, which are released from the membrane upon cleavage of the inositol-phosphate linkage. For example, cleavage and release of UPAR/PLAUR regulates cell-matrix adhesion and extracellular matrix remodeling. Also cleaves the glycosylphosphatidylinositol (GPI) anchor of metalloproteases TRABD2A and TRABD2B, releasing them from the plasma membrane. This release modulates their regulation of Wnt signaling. Also hydrolyzes lysophosphatidylinositol (LPI) to monoacylglycerol and inositol-1-phosphate (By similarity). Also hydrolyzes lysophosphatidylinositol (LPI) to monoacylglycerol and inositol-1-phosphate. Converts 2-arachidonoyl-LPI, the endogenous GPR55 agonist, into 2-arachidonoylglycerol (2-AG), an endocannabinoid that activates CNR1/CNR2. Thereby, acts as a switch redirecting signaling from GPR55 to CNR1/CNR2 within the endocannabinoid system that could alternatively regulate osteoblast proliferation and differentiation (PubMed:12933806, PubMed:32629025, PubMed:32917725). Can also cleave glycerophosphoinositol to glycerol and inositol-1-phosphate in vitro (PubMed:19596859). May also play a role in remodeling of the actin cytoskeleton (PubMed:12933806, PubMed:19596859)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; GDE3 is a novel seven-transmembrane protein with a GP-PDE-like extracellular motif expressed during osteoblast differentiation that accelerates the program of osteoblast differentiation and is involved in morphological change of cells, [RefSeq, PubMed]; GDE3 substrate GroPIns is a candidate mediator for osteoblast proliferation, [RefSeq, PubMed]; Nitric oxide hinders club cell proliferation through Gdpd2 during allergic airway inflammation., [RefSeq, PubMed]; The results establish GDE3 as a negative regulator of the uPAR signaling network and, furthermore, highlight GPI-anchor hydrolysis as a cell-intrinsic mechanism to alter cell behavior. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9652, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.2;3.1.4.43", "go_molecular_function": "GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity;GO:0046872 metal ion binding;GO:0004629 phospholipase C activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0007015 actin filament organization;GO:0009306 protein secretion;GO:0045669 positive regulation of osteoblast differentiation;GO:0006505 GPI anchor metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9ESM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EST1-1", "uniprot_id": "GSDMA_MOUSE", "mass": 49593.0, "length": 446, "protein_name": "Gasdermin-A", "gene_name": "Gsdma", "organism": "Mouse", "refseq_name": "gasdermin-A", "refseq_ac": "NP_067322", "gene_names_uniprotkb": "Gsdma; Gsdm1; Gsdma1; Gsdm", "gene_names_refseq": "Gsdm1; Gsdma1; Gsdma; Gsdm; H312E", "protein_names_uniprotkb": "Gasdermin-A; Gasdermin-1; Gasdermin-A1", "protein_names_refseq": "gasdermin 1; gasdermin-A1; gasdermin-A", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:57911)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10967128;17350798;35034587;35110732;35545676;36965577", "class_list": "", "function": "CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis., [RefSeq, PubMed]; Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model., [RefSeq, PubMed]; Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:35110732). Released upon cleavage by bacterial effector protein SpeB, and binds to membrane inner leaflet lipids (PubMed:35110732). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity). Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response (PubMed:35110732, PubMed:35545676). This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen (PubMed:35110732, PubMed:35545676). Binds to cardiolipin and other acidic phospholipids, such as phosphatidylserine, which mediate its targeting to the inner leaflet membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This form constitutes the precursor of the pore-forming protein and acts as a sensor of bacterial infection: upon infection, specifically cleaved by bacterial effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N-terminal) that binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KFN3", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EST1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESY9-1", "uniprot_id": "GILT_MOUSE", "mass": 27784.0, "length": 248, "protein_name": "Gamma-interferon-inducible lysosomal thiol reductase", "gene_name": "Ifi30", "organism": "Mouse", "refseq_name": "gamma-interferon-inducible lysosomal thiol reductase precursor", "refseq_ac": "NP_075552", "gene_names_uniprotkb": "Ifi30; Gilt; Ip30", "gene_names_refseq": "GILT; IP30; Ifi30", "protein_names_uniprotkb": "Gamma-interferon-inducible lysosomal thiol reductase; 1.8.4.-; Gamma-interferon-inducible protein IP-30; Lysosomal thiol reductase IP30", "protein_names_refseq": "gamma-interferon-inducible lysosomal thiol reductase precursor; gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30; lysosomal thio reductase IP30; lysosomal thiol reductase IP30", "tax_id": 10090, "disease": "", "pathway": " (mmu:65972); (R-MMU-2132295)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11701933;18250455;18815593;20538950;26495903;26740625;27802388;28011936;30059200;32269095;34015674;40885482", "class_list": "", "function": "Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells., [RefSeq, PubMed]; GILT facilitated the processing and presentation to antigen-specific T cells of protein antigens containing disulfide bonds., [RefSeq, PubMed]; GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen., [RefSeq, PubMed]; Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction (By similarity). Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation (PubMed:11701933, PubMed:20538950). Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate (Probable). Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme (Probable). Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction (By similarity). Dithiothreitol, cysteine, and cysteinyl glycine, but not glutathione, are capable of regenerating active precursor and mature IFI30 in vitro (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3X911;Q3U0F9;Q9EP56", "ec_number_list": "1.8.4.-", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0016667 oxidoreductase activity, acting on a sulfur group of donors;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0030054 cell junction;GO:0005764 lysosome", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050821 protein stabilization;GO:0048147 negative regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9ESY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI57-1", "uniprot_id": "GT2D1_MOUSE", "mass": 123483.0, "length": 1104, "protein_name": "General transcription factor II-I repeat domain-containing protein 1", "gene_name": "Gtf2ird1", "organism": "Mouse", "refseq_name": "general transcription factor II-I repeat domain-containing protein 1 isoform b", "refseq_ac": "NP_001074931", "gene_names_uniprotkb": "Gtf2ird1; Ben", "gene_names_refseq": "1700012P16Rik; BEN; Cream1; ESTM9; GTF3; Gtf2il; Gtf2ird1; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11", "protein_names_uniprotkb": "General transcription factor II-I repeat domain-containing protein 1; Binding factor for early enhancer; GTF2I repeat domain-containing protein 1", "protein_names_refseq": "Alb/c-myc line 166.8; GTF2I repeat domain-containing 1; GTF2I repeat domain-containing protein 1; Williams-Beuren syndrome chromosome region 11; binding factor for early enhancer; c-myc line 166.8; general transcription factor 3; general transcription factor II-I repeat domain-containing protein 1 isoform b; general transcription factor II-I repeat domain-containing protein 1; muscle TFII-I repeat domain-containing protein 1; transcription factor GTF3 alpha 2; transcription factor GTF3 gamma 2", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:57080)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10861001;11352562;11438732;11827466;12780350;21750661;32313931", "class_list": "", "function": "Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA binding and long-term behavioral consequences., [RefSeq, PubMed]; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q547E0;Q80WJ8;Q80WJ9;Q80WK0;Q80WK1;Q8R4X5;Q8R4X6;Q8R4X7;Q8R4X8;Q8VHD5;Q8VI58;Q9EQE7;Q9ESZ6;Q9ESZ7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0014886 transition between slow and fast fiber;GO:0006351 DNA-templated transcription;GO:0014733 regulation of skeletal muscle adaptation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JI57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK38-1", "uniprot_id": "GNA1_MOUSE", "mass": 20791.0, "length": 184, "protein_name": "Glucosamine 6-phosphate N-acetyltransferase", "gene_name": "Gnpnat1", "organism": "Mouse", "refseq_name": "glucosamine 6-phosphate N-acetyltransferase isoform 4", "refseq_ac": "NP_062298", "gene_names_uniprotkb": "Gnpnat1; Gna1", "gene_names_refseq": "EMeg32; Gnpnat1; Gpnat1; Gsnpat", "protein_names_uniprotkb": "Glucosamine 6-phosphate N-acetyltransferase; 2.3.1.4; Phosphoglucosamine acetylase; Phosphoglucosamine transacetylase; Protein EMeg32", "protein_names_refseq": "glucosamine 6-phosphate N-acetyltransferase isoform 4; glucosamine 6-phosphate N-acetyltransferase; glucosamine-6-phosphate acetyltransferase; glucosamine-phosphate N-acetyltransferase 1; glucosamine-phosphate N-acetyltransferase; phosphoglucosamine acetylase; phosphoglucosamine transacetylase", "tax_id": 10090, "disease": "keratosis follicularis spinulosa decalvans (Disease Ontology:DOID:0080753); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:54342); (R-MMU-446210)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10777580;21750661;22872234;25428506;25605945;34203471;34428180;37453647;37507081", "class_list": "glycogene", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.4", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005770 late endosome;GO:0010008 endosome membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:1990830 cellular response to leukemia inhibitory factor;GO:0006041 glucosamine metabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JK38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL60-1", "uniprot_id": "GMEB1_MOUSE", "mass": 61058.0, "length": 562, "protein_name": "Glucocorticoid modulatory element-binding protein 1", "gene_name": "Gmeb1", "organism": "Mouse", "refseq_name": "glucocorticoid modulatory element-binding protein 1", "refseq_ac": "NP_001116464", "gene_names_uniprotkb": "Gmeb1", "gene_names_refseq": "1110050A04Rik; Gmeb1", "protein_names_uniprotkb": "Glucocorticoid modulatory element-binding protein 1; GMEB-1", "protein_names_refseq": "GMEB-1; glucocorticoid modulatory element-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56809)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10692587;25428506;31175277;32782141;35820727", "class_list": "", "function": "Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling. Specifically binds AT-rich DNA motifs known as glucocorticoid modulatory elements (GMEs), repressing or enhancing transcription depending on cellular context. Forms heterodimeric complexes with GMEB2, which enhances its DNA-binding specificity and transcriptional activity. This complex plays a critical role in the repression of glucocorticoid receptor (GR/NR3C1) transcriptional activity, acting as a negative modulator of glucocorticoid signaling (By similarity). Regulates dopamine-enriched midbrain genes, including tyrosine hydroxylase/TH and the dopamine transporter SLC6A3, essential for dopamine signaling (PubMed:31175277). Also binds the transferrin receptor promoter. In the cytoplasm, inhibits caspase activation and neuronal apoptosis by stabilizing CFLARL and blocking pro-caspase 8 activation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Gmeb1 knockdown in midbrain dopamine (mDA) neurons resulted in downregulation of tyrosine hydroxylase and dopamine transporter, as well as in severe motor deficits. This study thus identifies Gmeb1 as a master regulator of mDA gene expression and function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y88", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JL60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYS2-1", "uniprot_id": "GRM3_MOUSE", "mass": 99114.0, "length": 879, "protein_name": "Metabotropic glutamate receptor 3", "gene_name": "Grm3", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 3 precursor", "refseq_ac": "NP_862898", "gene_names_uniprotkb": "Grm3; Gprc1c; Mglur3", "gene_names_refseq": "0710001G23Rik; Gprc1c; Grm3; mGlu3; mGluR3", "protein_names_uniprotkb": "Metabotropic glutamate receptor 3; mGluR3", "protein_names_refseq": "G protein-coupled receptor, family C, group 1, member C; metabotropic glutamate receptor 3 precursor; metabotropic glutamate receptor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:108069); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10544282;30899004;33300544;35822049;38864289", "class_list": "", "function": "Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses., [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q14DJ9", "ec_number_list": "", "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0097110 scaffold protein binding;GO:0001641 group II metabotropic glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043197 dendritic spine", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0019233 sensory perception of pain;GO:0035249 synaptic transmission, glutamatergic;GO:0051930 regulation of sensory perception of pain;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9QYS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R087-1", "uniprot_id": "GPC6_MOUSE", "mass": 63057.0, "length": 555, "protein_name": "Glypican-6", "gene_name": "Gpc6", "organism": "Mouse", "refseq_name": "glypican-6 isoform 2 precursor", "refseq_ac": "NP_035951", "gene_names_uniprotkb": "Gpc6", "gene_names_refseq": "Gpc6", "protein_names_uniprotkb": "Glypican-6", "protein_names_refseq": "glypican-6 isoform 2 precursor", "tax_id": 10090, "disease": "omodysplasia 1 (Disease Ontology:DOID:0080844)", "pathway": " (mmu:23888); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "10480909;16452087;19481194;25428506", "class_list": "glycogene", "function": "Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0016477 cell migration;GO:0009966 regulation of signal transduction;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1K6-1", "uniprot_id": "GPR34_MOUSE", "mass": 43173.0, "length": 375, "protein_name": "Probable G protein-coupled receptor 34", "gene_name": "Gpr34", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 34", "refseq_ac": "NP_035953", "gene_names_uniprotkb": "Gpr34", "gene_names_refseq": "Gpr34; Lypsr1", "protein_names_uniprotkb": "Probable G protein-coupled receptor 34", "protein_names_refseq": "G-protein-coupled receptor; probable G-protein coupled receptor 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:23890)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10395919;21097509;22343749;25142016;25428506;26851221;34107271;39358444", "class_list": "", "function": "G protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:21097509, PubMed:26851221, PubMed:34107271). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (PubMed:34107271). Plays an important role in microglial function, controlling morphology and phagocytosis (PubMed:25142016)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity. Erratum:[Nat Immunol. 2024 Nov;25(11):2167. doi: 10.1038/s41590-024-02001-w. PMID: 39375551], [RefSeq, PubMed]; GPR34-deficient mice showed significantly increased paw swelling in the delayed type hypersensitivity test and higher pathogen burden in extrapulmonary tissues after pulmonary infection with Cryptococcus neoformans compared with wild-type mice., [RefSeq, PubMed]; The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R1K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU65-1", "uniprot_id": "GLPK2_MOUSE", "mass": 60630.0, "length": 554, "protein_name": "Glycerol kinase 2", "gene_name": "Gk2", "organism": "Mouse", "refseq_name": "glycerol kinase 2", "refseq_ac": "NP_034424", "gene_names_uniprotkb": "Gk2; Gk-rs2; Gkrs2", "gene_names_refseq": "GKTA; Gk-rs2; Gk2", "protein_names_uniprotkb": "Glycerol kinase 2; 2.7.1.30; ATP:glycerol 3-phosphotransferase 2; GK 2; Glycerokinase 2; Glycerol kinase, testis specific 2", "protein_names_refseq": "ATP:glycerol 3-phosphotransferase 2; GK 2; glucokinase activity, related sequence 2; glycerokinase 2; glycerol kinase 2; glycerol kinase, testis specific 2", "tax_id": 10090, "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363)", "pathway": " (mmu:14626); (R-MMU-75109)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10444329;28852571;30662012;33300544;34428180", "class_list": "", "function": "GK2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis., [RefSeq, PubMed]; Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (PubMed:28852571, PubMed:30662012). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (PubMed:30662012). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.30", "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WU65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2A9-1", "uniprot_id": "GGT5_MOUSE", "mass": 61674.0, "length": 573, "protein_name": "Glutathione hydrolase 5 proenzyme", "gene_name": "Ggt5", "organism": "Mouse", "refseq_name": "glutathione hydrolase 5 proenzyme isoform 1 precursor", "refseq_ac": "NP_035950", "gene_names_uniprotkb": "Ggt5; Ggtla1", "gene_names_refseq": "GGL; GGT-REL; Ggt5; Ggtla1", "protein_names_uniprotkb": "Glutathione hydrolase 5 proenzyme; 2.3.2.2; 3.4.19.13; 3.4.19.14; GGL; GGT 5; Gamma-glutamyl leukotrienase; Gamma-glutamyltransferase 5; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase", "protein_names_refseq": "gamma-glutamyl leukotrienase; gamma-glutamyltransferase-like activity 1; gamma-glutamyltranspeptidase 5; glutathione hydrolase 5 proenzyme isoform 1 precursor; glutathione hydrolase 5 proenzyme; leukotriene-C4 hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:23887); (R-MMU-174403); (R-MMU-2142691); (R-MMU-5423646); (R-MMU-9753281)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11463821;12163373;21750661;27397680;30084848;30842656;30899004;34088745;34428180;9774450", "class_list": "", "function": "Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione., [RefSeq, PubMed]; Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates (PubMed:11463821, PubMed:12163373, PubMed:30842656, PubMed:9774450). Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis (By similarity). Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine (PubMed:11463821, PubMed:12163373, PubMed:9774450). Converts extracellular LTC4 to LTD4 during acute inflammatory response (PubMed:11463821). Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (PubMed:30842656, PubMed:34088745). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; GGT5/oxidative stress cascade plays a central role during luteinizing hormone-stimulated steroidogenesis., [RefSeq, PubMed]; Plays an important role in inflammatory processes, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7B4", "ec_number_list": "2.3.2.2;3.4.19.13;3.4.19.14", "go_molecular_function": "GO:0000048 peptidyltransferase activity;GO:0002951 leukotriene-C(4) hydrolase;GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:0006508 proteolysis;GO:0006631 fatty acid metabolic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9Z2A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQF2-1", "uniprot_id": "KELL_MOUSE", "mass": 80866.0, "length": 713, "protein_name": "Kell blood group glycoprotein homolog", "gene_name": "Kel", "organism": "Mouse", "refseq_name": "kell blood group glycoprotein homolog isoform 1", "refseq_ac": "NP_115929", "gene_names_uniprotkb": "Kel", "gene_names_refseq": "CD238; Ece3; Kel", "protein_names_uniprotkb": "Kell blood group glycoprotein homolog; 3.4.24.-", "protein_names_refseq": "Kel blood group protein; Kell blood group, metallo-endopeptidase; Kell protein; kell blood group glycoprotein homolog isoform 1; kell blood group glycoprotein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:23925); (R-MMU-375276)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11132157;19544475;21750661;23122227;25428506;28836263", "class_list": "", "function": "Absence of Kell was accompanied by changes in erythrocyte K(+), Mg(2+), Na(+) & Ca(2+) transport associated with changes in mean cellular volume & corpuscular hemoglobin concentration mean. Kel loss increased Mg(2+) permeability. Erratum:[Blood Cells Mol Dis. 2014 Jan;52(1):52], [RefSeq, PubMed]; B cells require signaling from IFN-alpha/beta to produce alloantibodies to the human KEL glycoprotein in mice, [RefSeq, PubMed]; The targeted disruption of Kel in mouse enabled us to identify phenotypes that would not be easily detected in humans lacking Kell glycoprotein., [RefSeq, PubMed]; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q499D7", "ec_number_list": "3.4.24.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1901380 negative regulation of potassium ion transmembrane transport;GO:0016485 protein processing;GO:0006874 intracellular calcium ion homeostasis;GO:0042552 myelination;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61622-1", "uniprot_id": "ITA11_MOUSE", "mass": 133012.0, "length": 1188, "protein_name": "Integrin alpha-11", "gene_name": "Itga11", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Itga11", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-11", "protein_names_refseq": "", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:319480); (R-MMU-216083)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;19656770;21750661;34428180", "class_list": "", "function": "Integrin alpha-11/beta-1 is a receptor for collagen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0038023 signaling receptor activity;GO:0038064 collagen receptor activity;GO:0098639 collagen binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0034681 integrin alpha11-beta1 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion;GO:0006929 substrate-dependent cell migration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P61622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD98-1", "uniprot_id": "KLRBF_MOUSE", "mass": 24681.0, "length": 217, "protein_name": "Killer cell lectin-like receptor subfamily B member 1F", "gene_name": "Klrb1f", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily B member 1F", "refseq_ac": "NP_694734", "gene_names_uniprotkb": "Klrb1f; Nkrp1f", "gene_names_refseq": "A630024B12Rik; Klrb1f; Nkr-p1f; Nkrp1-f; Nkrp1f", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1F; CD161 antigen-like family member F; Natural killer cell surface protein NKR-P1F", "protein_names_refseq": "CD161 antigen-like family member F; killer cell lectin-like receptor subfamily B member 1F; natural killer cell surface protein NKR-P1F", "tax_id": 10090, "disease": "", "pathway": " (mmu:232408)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11685472;12858173;15963483;16143319;16751398;21750661;23071282;30995786;31219806", "class_list": "glycogene", "function": "Binds CLEC2I/Clr-g leading to activation of natural killer cells or costimulation of IL-2 production and proliferation of T-cells in response to antigen stimulation. May contribute to the formation of the immunological synapse between T-cells and antigen-presenting dendritic cells., [UniProtKB, PubMed, PubMed, PubMed]; Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface. Publication Status: Online-Only, [RefSeq, PubMed]; Studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo, [RefSeq, PubMed]; The electrostatic profile of NKR-P1F is complementary to that of Clr-g, which suggests a plausible interaction mechanism based on contacts between surface sites of opposite potential., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1AFZ8;Q3TDT3;Q8C9Q1", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VD98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFQ9-1", "uniprot_id": "KLH42_MOUSE", "mass": 55599.0, "length": 493, "protein_name": "Kelch-like protein 42", "gene_name": "Klhl42", "organism": "Mouse", "refseq_name": "kelch-like protein 42 isoform a", "refseq_ac": "NP_001074706", "gene_names_uniprotkb": "Klhl42; Kiaa1340; Klhdc5", "gene_names_refseq": "A330079N23Rik; C230080I20Rik; Ctb9; Klhdc5; Klhl42; mKIAA1340", "protein_names_uniprotkb": "Kelch-like protein 42; Ctb9; Cullin-3-binding protein 9; Kelch domain-containing protein 5", "protein_names_refseq": "cullin-3-binding protein 9; kelch domain containing 5; kelch domain-containing protein 5; kelch-like protein 42 isoform a; kelch-like protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:232539); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "19261606;21750661;22872234;31219806;34203471;34428180;35820727", "class_list": "", "function": "Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPT4", "ec_number_list": "", "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032886 regulation of microtubule-based process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BFQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V300-1", "uniprot_id": "KIF22_MOUSE", "mass": 73190.0, "length": 660, "protein_name": "Kinesin-like protein KIF22", "gene_name": "Kif22", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF22 isoform 1", "refseq_ac": "NP_663563", "gene_names_uniprotkb": "Kif22", "gene_names_refseq": "Kid; Kif22a; Kif22", "protein_names_uniprotkb": "Kinesin-like protein KIF22", "protein_names_refseq": "kinesin family member 22A; kinesin-like protein KIF22 isoform 1; kinesin-like protein KIF22", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia with joint laxity type 2 (Disease Ontology:DOID:0112199)", "pathway": " (mmu:110033); (R-MMU-2132295); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "18329364;21750661;27550518;31219806;34428180;34887587;9339368", "class_list": "", "function": "Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells., [UniProtKB, UniProtKB, UniProtKB]; Phosphorylation of Thr463 switches the mitotic chromosome movement from an anti-poleward direction to a poleward direction by converting the Kid functional mode from polar-ejection-force-ON to -OFF during the metaphase-anaphase transition., [RefSeq, PubMed]; These data suggest that Kid-mediated anaphase/telophase chromosome compaction prevents formation of multinucleated cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35232;Q99LC7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016607 nuclear speck", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0006281 DNA repair;GO:0007018 microtubule-based movement;GO:0007080 mitotic metaphase chromosome alignment;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3V300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2P1-1", "uniprot_id": "KLH25_MOUSE", "mass": 65826.0, "length": 589, "protein_name": "Kelch-like protein 25", "gene_name": "Klhl25", "organism": "Mouse", "refseq_name": "kelch-like protein 25", "refseq_ac": "NP_001116252", "gene_names_uniprotkb": "Klhl25", "gene_names_refseq": "2810402K13Rik; Enc-1; Klhl25", "protein_names_uniprotkb": "Kelch-like protein 25", "protein_names_refseq": "ENC-2; ectoderm-neural cortex protein 2; ectoderm-neural cortex-1; kelch-like protein 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:207952); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;22578813;34491895", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0016567 protein ubiquitination;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R2P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTH8-1", "uniprot_id": "KC1G1_MOUSE", "mass": 52744.0, "length": 459, "protein_name": "Casein kinase I isoform gamma-1", "gene_name": "Csnk1g1", "organism": "Mouse", "refseq_name": "casein kinase I isoform gamma-1", "refseq_ac": "NP_775277", "gene_names_uniprotkb": "Csnk1g1", "gene_names_refseq": "9130020E21Rik; Csnk1g1", "protein_names_uniprotkb": "Casein kinase I isoform gamma-1; 2.7.11.1; CKI-gamma 1", "protein_names_refseq": "CKI-gamma 1; casein kinase I isoform gamma-1; casein kinase I, gamma 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:214897)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16014721;21750661;31219806;31801942", "class_list": "", "function": "CK1 regulates fast synaptic transmission by glutamate in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 &/or 2A & increased dephosphorylation of NMDA receptors., [RefSeq, PubMed]; Casein kinase-1gamma1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CLSPN (By similarity). Regulates fast synaptic transmission mediated by glutamate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QPK6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0046777 protein autophosphorylation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BTH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T74-1", "uniprot_id": "KLH29_MOUSE", "mass": 94359.0, "length": 875, "protein_name": "Kelch-like protein 29", "gene_name": "Klhl29", "organism": "Mouse", "refseq_name": "kelch-like protein 29", "refseq_ac": "NP_001157965", "gene_names_uniprotkb": "Klhl29; Kbtbd9; Kiaa1921", "gene_names_refseq": "A230106N14Rik; Gm68; Kbtbd9; Klhl29; mKIAA1921", "protein_names_uniprotkb": "Kelch-like protein 29; Kelch repeat and BTB domain-containing protein 9", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 9; kelch repeat and BTB domain-containing protein 9; kelch-like protein 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:208439)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6H646", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80T74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYE5-1", "uniprot_id": "JAG2_MOUSE", "mass": 134745.0, "length": 1247, "protein_name": "Protein jagged-2", "gene_name": "Jag2", "organism": "Mouse", "refseq_name": "protein jagged-2 isoform 1 precursor", "refseq_ac": "NP_034718", "gene_names_uniprotkb": "Jag2", "gene_names_refseq": "D12Ggc2e; Jag2; Serh; mJagged2-1; sm", "protein_names_uniprotkb": "Protein jagged-2; Jagged2", "protein_names_refseq": "protein jagged-2 isoform 1 precursor; protein jagged-2; syndactylism", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 27 (Disease Ontology:DOID:0061133); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:16450); (R-MMU-2122948); (R-MMU-9013507)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;9315665;9341252;9486542", "class_list": "", "function": "Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "F8VPV5;O55139;O70219", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0045061 thymic T cell selection;GO:0001701 in utero embryonic development;GO:0003016 respiratory system process;GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QYE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ADZ8-1", "uniprot_id": "IQCC_MOUSE", "mass": 46912.0, "length": 418, "protein_name": "IQ domain-containing protein C", "gene_name": "Iqcc", "organism": "Mouse", "refseq_name": "IQ domain-containing protein C isoform 1", "refseq_ac": "NP_932143", "gene_names_uniprotkb": "Iqcc", "gene_names_refseq": "Iqcc", "protein_names_uniprotkb": "IQ domain-containing protein C", "protein_names_refseq": "IQ domain-containing protein C isoform 1; IQ domain-containing protein C", "tax_id": 10090, "disease": "", "pathway": " (mmu:230767)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0F9;Q8R0F4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2ADZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTY1-1", "uniprot_id": "KAT1_MOUSE", "mass": 47564.0, "length": 424, "protein_name": "Kynurenine--oxoglutarate transaminase 1", "gene_name": "Kyat1", "organism": "Mouse", "refseq_name": "kynurenine--oxoglutarate transaminase 1 isoform a", "refseq_ac": "NP_765992", "gene_names_uniprotkb": "Kyat1; Ccbl1; Kat", "gene_names_refseq": "2010009K05Rik; Ccbl1; Gtk; Kat1; KatI; Kyat1", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 1; 2.6.1.64; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase; GTK; Glutamine transaminase K; Glutamine--phenylpyruvate transaminase; KATI; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; Kynurenine--oxoglutarate transaminase I", "protein_names_refseq": "cysteine conjugate-beta lyase 1; cysteine-S-conjugate beta-lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); glutamine transaminase K; glutamine--phenylpyruvate transaminase; kynurenine aminotransferase I; kynurenine--oxoglutarate transaminase 1 isoform a; kynurenine--oxoglutarate transaminase 1; kynurenine--oxoglutarate transaminase I", "tax_id": 10090, "disease": "", "pathway": " (mmu:70266); (R-MMU-71240); (R-MMU-8964208); (R-MMU-8964539)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "20482848;21750661;23806337;28097769;30084848;37507081", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; KAT I inhibited by equimolar tryptophan and half-life is 69.7 minutes at 65 degree C. Publication Status: Online-Only, [RefSeq, PubMed]; One is the native structure with the cofactor in the PLP form bound to Lys247 with the highest resolution yet available for KAT-I at 1.28 A resolution, and the other with the general PLP-dependent aminotransferase inhibitor, aminooxyacetate (AOAA) covalently bound to the cofactor at 1.54 A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY27", "ec_number_list": "2.6.1.7;2.6.1.1;4.4.1.13;2.6.1.63;2.6.1.64;2.6.1.39;2.6.1.4;2.6.1.73", "go_molecular_function": "GO:0047316 glutamine-phenylpyruvate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0070189 kynurenine metabolic process;GO:0009617 response to bacterium;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BTY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6PWV3-1", "uniprot_id": "IZUM3_MOUSE", "mass": 30314.0, "length": 263, "protein_name": "Izumo sperm-egg fusion protein 3", "gene_name": "Izumo3", "organism": "Mouse", "refseq_name": "izumo sperm-egg fusion protein 3 precursor", "refseq_ac": "NP_081310", "gene_names_uniprotkb": "Izumo3", "gene_names_refseq": "1700011H22Rik; Izumo3", "protein_names_uniprotkb": "Izumo sperm-egg fusion protein 3", "protein_names_refseq": "izumo sperm-egg fusion protein 3 precursor; izumo sperm-egg fusion protein 3; transmembrane protein C9orf134", "tax_id": 10090, "disease": "", "pathway": " (mmu:69314); (R-MMU-1300645)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19658160;21750661;34114279", "class_list": "", "function": "IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation., [RefSeq, PubMed]; Plays an important role in the biogenesis of the acrosome during sperm development., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAG1", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0002079 inner acrosomal membrane", "go_biological_process": "GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A6PWV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0M1-1", "uniprot_id": "KPRA_MOUSE", "mass": 39432.0, "length": 356, "protein_name": "Phosphoribosyl pyrophosphate synthase-associated protein 1", "gene_name": "Prpsap1", "organism": "Mouse", "refseq_name": "phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 3", "refseq_ac": "NP_080640", "gene_names_uniprotkb": "Prpsap1", "gene_names_refseq": "5730409F23Rik; PAP39; Prpsap1", "protein_names_uniprotkb": "Phosphoribosyl pyrophosphate synthase-associated protein 1; 39 kDa phosphoribosypyrophosphate synthase-associated protein; PAP39; PRPP synthase-associated protein 1", "protein_names_refseq": "39 kDa phosphoribosypyrophosphate synthase-associated protein; 39 kDa phosphoribosypyrophosphate synthetase-associated protein; PRPP synthase-associated protein 1; PRPP synthetase-associated protein 1; phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 3; phosphoribosyl pyrophosphate synthase-associated protein 1", "tax_id": 10090, "disease": "X-linked nonsyndromic deafness (Disease Ontology:DOID:0050566); Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210)", "pathway": " (mmu:67763)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;25605945;27802388;28528544;30084848;30779550;31219806;34428180;35820727;37828378", "class_list": "", "function": "Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0033673 negative regulation of kinase activity;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0009165 nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9D0M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52187-1", "uniprot_id": "KCJ12_MOUSE", "mass": 48427.0, "length": 427, "protein_name": "ATP-sensitive inward rectifier potassium channel 12", "gene_name": "Kcnj12", "organism": "Mouse", "refseq_name": "ATP-sensitive inward rectifier potassium channel 12 isoform 2", "refseq_ac": "NP_001254522", "gene_names_uniprotkb": "Kcnj12; Irk2", "gene_names_refseq": "IRK-2; IRK2; Kcnj12; Kir2.2; MB-IRK2", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 12; IRK-2; Inward rectifier K(+) channel Kir2.2; Potassium channel, inwardly rectifying subfamily J member 12", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 12 isoform 2; ATP-sensitive inward rectifier potassium channel 12; inward rectifier K(+) channel Kir2.2", "tax_id": 10090, "disease": "EAST syndrome (Disease Ontology:DOID:0060484)", "pathway": " (mmu:16515); (R-MMU-1296041); (R-MMU-1296053); (R-MMU-5576886); (R-MMU-997272)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "21750661;25428506;32990585;8083233", "class_list": "", "function": "A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells (By similarity). It probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCR0;Q9QYF2", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030165 PDZ domain binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52187-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YS8-1", "uniprot_id": "KCC1A_MOUSE", "mass": 41624.0, "length": 374, "protein_name": "Calcium/calmodulin-dependent protein kinase type 1", "gene_name": "Camk1", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase type 1", "refseq_ac": "NP_598687", "gene_names_uniprotkb": "Camk1", "gene_names_refseq": "CaMKIalpha; Camk1; Camk; D6Ertd263e", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1; 2.7.11.17; CaM kinase I alpha; CaM kinase I; CaM-KI; CaMKI-alpha", "protein_names_refseq": "caM kinase I alpha; caM-KI; caMKI-alpha; calcium/calmodulin-dependent protein kinase type 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52163); (R-MMU-9619229)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12538590;15150258;21750661;25153642;28135057;28528544;35145192;35412911;35820727;38216068", "class_list": "", "function": "A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences, [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-673', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I (By similarity)., [UniProtKB, PubMed]; ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI, [RefSeq, PubMed]; IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91YS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCV7-1", "uniprot_id": "K2C7_MOUSE", "mass": 50709.0, "length": 457, "protein_name": "Keratin, type II cytoskeletal 7", "gene_name": "Krt7", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 7", "refseq_ac": "NP_149064", "gene_names_uniprotkb": "Krt7; Krt2-7", "gene_names_refseq": "D15Wsu77e; K7; Krt2-7; Krt7", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 7; CK-7; Cytokeratin-7; K7; Keratin-7; Type-II keratin Kb7", "protein_names_refseq": "CK-7; Cytokeratin 7; cytokeratin-7; keratin complex 2, basic, gene 7; keratin, type II cytoskeletal 7; sarcolectin; type-II keratin Kb7", "tax_id": 10090, "disease": "pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:110310); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12359226;18299400;21183079;21750661;32152506;34428180;37660597", "class_list": "", "function": "Blocks interferon-dependent interphase and stimulates DNA synthesis in cells., [UniProtKB]; Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DCV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSH7-1", "uniprot_id": "KCNF1_MOUSE", "mass": 55647.0, "length": 493, "protein_name": "Voltage-gated potassium channel regulatory subunit KCNF1", "gene_name": "Kcnf1", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel regulatory subunit KCNF1", "refseq_ac": "NP_963289", "gene_names_uniprotkb": "Kcnf1", "gene_names_refseq": "Gm1182; Kcnf1; Kv5.1", "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNF1; Potassium voltage-gated channel subfamily F member 1; Voltage-gated potassium channel subunit Kv5.1", "protein_names_refseq": "voltage-gated potassium channel regulatory subunit KCNF1; voltage-gated potassium channel subunit Kv5.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:382571); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex;GO:0097546 ciliary base", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0043266 regulation of potassium ion transport;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TSH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86046-1", "uniprot_id": "KCJ13_MOUSE", "mass": 40565.0, "length": 360, "protein_name": "Inward rectifier potassium channel 13", "gene_name": "Kcnj13", "organism": "Mouse", "refseq_name": "inward rectifier potassium channel 13", "refseq_ac": "NP_001103697", "gene_names_uniprotkb": "Kcnj13", "gene_names_refseq": "100040591; Kcnj13; Kir7.1", "protein_names_uniprotkb": "Inward rectifier potassium channel 13; Inward rectifier K(+) channel Kir7.1; Potassium channel, inwardly rectifying subfamily J member 13", "protein_names_refseq": "inward rectifier K(+) channel Kir7.1; inward rectifier potassium channel 13", "tax_id": 10090, "disease": "Leber congenital amaurosis 16 (Disease Ontology:DOID:0110118); snowflake vitreoretinal degeneration (Disease Ontology:DOID:0111570); Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:100040591)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;25056913;25600267;30228185;31056263;31309576;32086565;39951488", "class_list": "", "function": "A critical role for the inward rectifying potassium channel Kir7.1 in oligodendrocytes of the mouse optic nerve., [RefSeq, PubMed]; Coupling of MC4R to Kir7.1 may explain unusual aspects of the control of energy homeostasis by melanocortin signalling, including the gene dosage effect of MC4R and the sustained effects of AgRP on food intake., [RefSeq, PubMed]; Glial and neuronal expression of the Inward Rectifying Potassium Channel Kir7.1 in the adult mouse brain., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium., [UniProtKB, UniProtKB]; Kir7.1 regulates the transition from quiescence to contractions in the pregnant uterus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005267 potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:1990573 potassium ion import across plasma membrane;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P86046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0T4-1", "uniprot_id": "ITAD_MOUSE", "mass": 127829.0, "length": 1168, "protein_name": "Integrin alpha-D", "gene_name": "Itgad", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Itgad", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-D", "protein_names_refseq": "", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:381924); (R-MMU-216083)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;29187734;30084848;34418053;34428180", "class_list": "", "function": "Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood., [UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 10, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0038023 signaling receptor activity;GO:0004895 cell adhesion receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0008305 integrin complex;GO:0034690 integrin alphaD-beta2 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0033631 cell-cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion;GO:0050798 activated T cell proliferation;GO:0034113 heterotypic cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3V0T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYN3-1", "uniprot_id": "ITPK1_MOUSE", "mass": 46145.0, "length": 419, "protein_name": "Inositol-tetrakisphosphate 1-kinase", "gene_name": "Itpk1", "organism": "Mouse", "refseq_name": "inositol-tetrakisphosphate 1-kinase", "refseq_ac": "NP_766172", "gene_names_uniprotkb": "Itpk1", "gene_names_refseq": "Itpk1", "protein_names_uniprotkb": "Inositol-tetrakisphosphate 1-kinase; 2.7.1.134; 2.7.1.159; Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase", "protein_names_refseq": "inositol 1,3,4-trisphosphate 5/6-kinase; inositol-tetrakisphosphate 1-kinase; inositol-triphosphate 5/6-kinase; ins(1,3,4)P(3) 5/6-kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:217837); (R-MMU-1855167); (R-MMU-1855204); (R-MMU-983231)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16537650;19914276;21750661;28528544;31219806;31599954", "class_list": "", "function": "Apical localization of Itpk1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis., [RefSeq, PubMed]; Data suggest that relative deficiency of one or more inositol phosphates accounts for neural tube defects in inositol 1,3,4-trisphosphate 5/6-kinase knockout mice., [RefSeq, PubMed]; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0J6;Q8R0Z0", "ec_number_list": "3.1.3.56;3.1.3.36;3.1.3.86;2.7.1.134;2.7.1.159", "go_molecular_function": "GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity;GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity;GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity;GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0021915 neural tube development;GO:0070266 necroptotic process;GO:0032957 inositol trisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BYN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35071-1", "uniprot_id": "KIF1C_MOUSE", "mass": 122434.0, "length": 1100, "protein_name": "Kinesin-like protein KIF1C", "gene_name": "Kif1c", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF1C", "refseq_ac": "NP_694743", "gene_names_uniprotkb": "Kif1c", "gene_names_refseq": "B430105J22Rik; D11Bwg1349e; Kif1c; Ltxs1; Orch3", "protein_names_uniprotkb": "Kinesin-like protein KIF1C", "protein_names_refseq": "N-3 kinsin; kinesin 1C; kinesin superfamily protein 1C; kinesin-like protein KIF1C; lethal factor toxin susceptibility 1", "tax_id": 10090, "disease": "spastic ataxia 2 (Disease Ontology:DOID:0050941); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:16562); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21183079;21750661;24129315;28096452;28528544;31217419;31887784;34428180;9275178", "class_list": "", "function": "Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas., [RefSeq, PubMed]; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility (By similarity)., [UniProtKB]; Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells. Publication Status: Online-Only, [RefSeq, PubMed]; The melanocore-interacting Kif1c-tail (M-INK) probe localize melanosomes in keratinocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SX62", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1990048 anterograde neuronal dense core vesicle transport;GO:1990049 retrograde neuronal dense core vesicle transport;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35071-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35231-1", "uniprot_id": "KIFC3_MOUSE", "mass": 92556.0, "length": 824, "protein_name": "Kinesin-like protein KIFC3", "gene_name": "Kifc3", "organism": "Mouse", "refseq_name": "kinesin-like protein KIFC3 isoform b", "refseq_ac": "NP_001139303", "gene_names_uniprotkb": "Kifc3", "gene_names_refseq": "Kifc3", "protein_names_uniprotkb": "Kinesin-like protein KIFC3", "protein_names_refseq": "kinesin-like protein KIFC3 isoform b; kinesin-like protein KIFC3", "tax_id": 10090, "disease": "", "pathway": " (mmu:16582)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11154264;11581287;21750661;22872234;29845728;34428180;38553728;39227687;9275178", "class_list": "", "function": "KIFC3 promotes the proliferation, migration and invasion of non-small cell lung cancer through the PI3K/AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The study connects defects in intracellular trafficking with insufficient autophagy in old organisms and identifies Kifc3 as a novel target for future interventions aiming at correcting autophagic activity with anti-aging purposes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35072;Q1WNZ8;Q3UX36;Q3V0U4;Q6NS71;Q8R3Y4;Q91YQ2;Q99KP7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0007030 Golgi organization;GO:0045218 zonula adherens maintenance;GO:0090136 epithelial cell-cell adhesion;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05555-1", "uniprot_id": "ITAM_MOUSE", "mass": 127481.0, "length": 1153, "protein_name": "Integrin alpha-M", "gene_name": "Itgam", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Itgam", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1", "protein_names_refseq": "", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); lupus nephritis (Disease Ontology:DOID:0080162); pre-eclampsia (Disease Ontology:DOID:10591); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); Behcet's disease (Disease Ontology:DOID:13241); atherosclerosis (Disease Ontology:DOID:1936); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); abdominal aortic aneurysm (Disease Ontology:DOID:7693); intermediate coronary syndrome (Disease Ontology:DOID:8805); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16409); (R-MMU-166016); (R-MMU-202733); (R-MMU-216083); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;11465105;18685038;21750661;25605945;26495903;26740625;28011936;29255075;2942940;30084848;3044779;30899004;31219806;34428180;35984892;3887182;39627609;8986723;9207125;9382884;9862668", "class_list": "", "function": "Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, and factor X. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Integrin ITGAM/ITGB2 is also a receptor for ICAM1 ligand ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 16, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA73", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0046872 metal ion binding;GO:0031072 heat shock protein binding;GO:0001851 complement component C3b binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:1904151 positive regulation of microglial cell mediated cytotoxicity;GO:0001774 microglial cell activation;GO:0006911 phagocytosis, engulfment;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P05555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08414-1", "uniprot_id": "KCC4_MOUSE", "mass": 52628.0, "length": 469, "protein_name": "Calcium/calmodulin-dependent protein kinase type IV", "gene_name": "Camk4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Camk4", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type IV; 2.7.11.17; CaM kinase-GR; CaMK IV", "protein_names_refseq": "", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (R-MMU-111932); (R-MMU-442729)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10932193;11572782;11951046;18829949;1893997;21183079;21750661;22645316;22826440;2536634;25605945;3033675;32848054;33300544;40885482;8195196;9727976", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). May be involved in spermatogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q61381", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P08414-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23299-1", "uniprot_id": "KCNE1_MOUSE", "mass": 14578.0, "length": 129, "protein_name": "Potassium voltage-gated channel subfamily E member 1", "gene_name": "Kcne1", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily E member 1", "refseq_ac": "NP_032450", "gene_names_uniprotkb": "Kcne1", "gene_names_refseq": "Isk; Kcne1; MinK; nmf190", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; MinK; Minimal potassium channel; mISK", "protein_names_refseq": "IKs producing slow voltage-gated potassium channel subunit beta Mink; delayed rectifier potassium channel subunit IsK; minimal potassium channel; potassium voltage-gated channel subfamily E member 1", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 5 (Disease Ontology:DOID:0110647); Jervell-Lange Nielsen syndrome (Disease Ontology:DOID:2842); long QT syndrome (Disease Ontology:DOID:2843); seminoma (Disease Ontology:DOID:4440); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:16509)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1568475;1655403;8900282", "class_list": "", "function": "Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0044877 protein-containing complex binding;GO:0031433 telethonin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903817 negative regulation of voltage-gated potassium channel activity;GO:0086003 cardiac muscle cell contraction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P23299-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48543-1", "uniprot_id": "KCNJ9_MOUSE", "mass": 43974.0, "length": 393, "protein_name": "G protein-activated inward rectifier potassium channel 3", "gene_name": "Kcnj9", "organism": "Mouse", "refseq_name": "G protein-activated inward rectifier potassium channel 3", "refseq_ac": "NP_032455", "gene_names_uniprotkb": "Kcnj9; Girk3", "gene_names_refseq": "1700085N21Rik; Girk3; Kcnj9; Kir3.3; mbGIRK3", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 3; GIRK-3; Inward rectifier K(+) channel Kir3.3; Potassium channel, inwardly rectifying subfamily J member 9", "protein_names_refseq": "G protein-activated inward rectifier potassium channel 3; GIRK-3; inward rectifier K(+) channel Kir3.3; inwardly rectifier K(+) channel Kir3.3; potassium channel, inwardly rectifying subfamily J member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:16524); (R-MMU-1296041); (R-MMU-997272)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10341034;7926018", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor is controlled by G proteins. Unable to produce channel activity when expressed alone (PubMed:7926018). Forms a functional channel in association with KCNJ3/GIRK1 (PubMed:10341034)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUE1", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015467 G-protein activated inward rectifier potassium channel activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:1990573 potassium ion import across plasma membrane;GO:0099505 regulation of presynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48543-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58390-1", "uniprot_id": "KCNN2_MOUSE", "mass": 63482.0, "length": 574, "protein_name": "Small conductance calcium-activated potassium channel protein 2", "gene_name": "Kcnn2", "organism": "Mouse", "refseq_name": "small conductance calcium-activated potassium channel protein 2 isoform SK2-L", "refseq_ac": "NP_001299834", "gene_names_uniprotkb": "Kcnn2; Sk2", "gene_names_refseq": "KCa2.2; Kcnn2; SK2; SKCA2; bc; fri", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 2; KCa2.2; SK2; SKCa 2; SKCa2", "protein_names_refseq": "small conductance calcium-activated potassium channel protein 2 isoform SK2-L; small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel subfamily N member 2", "tax_id": 10090, "disease": "myoclonic dystonia 34 (Disease Ontology:DOID:0060957); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); essential tremor (Disease Ontology:DOID:4990)", "pathway": " (mmu:140492); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11557517;13679367;14657188;16055520;18624921;20689065;21750661;33029124;37469037;38336298", "class_list": "", "function": "MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice., [RefSeq, PubMed]; Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-kappaB signaling pathway., [RefSeq, PubMed]; Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11557517, PubMed:13679367, PubMed:14657188). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:14657188). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:13679367). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B0GT12;B4YDY0;E9QNY5;Q3UF29;Q540U9;Q8CCH4", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0006811 monoatomic ion transport;GO:0043268 positive regulation of potassium ion transport;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P58390-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00651-1", "uniprot_id": "ITA4_MOUSE", "mass": 115696.0, "length": 1039, "protein_name": "Integrin alpha-4", "gene_name": "Itga4", "organism": "Mouse", "refseq_name": "integrin alpha-4 precursor", "refseq_ac": "NP_034706", "gene_names_uniprotkb": "Itga4", "gene_names_refseq": "CD49D; Itga4B; Itga4", "protein_names_uniprotkb": "Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; LPAM subunit alpha; Lymphocyte Peyer patch adhesion molecules subunit alpha; VLA-4 subunit alpha", "protein_names_refseq": "CD49 antigen-like family member D; LPAM subunit alpha; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha; integrin alpha-4 precursor; integrin alpha-IV; integrin alpha4B; lymphocyte Peyer patch adhesion molecules subunit alpha", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); pre-eclampsia (Disease Ontology:DOID:10591); nephritis (Disease Ontology:DOID:10952); pancreatic cancer (Disease Ontology:DOID:1793); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pneumonia (Disease Ontology:DOID:552); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:16401); (R-MMU-198933); (R-MMU-202733); (R-MMU-216083)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18250455;1840602;19144319;21183079;25428506;26495903;28011936;30899004;32152506;34428180;35802072;35984892;38806623", "class_list": "", "function": "Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072)., [UniProtKB, UniProtKB, PubMed]; The protective roles of integrin alpha4beta7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 8, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding;GO:1990405 protein antigen binding;GO:0001968 fibronectin binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q00651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0ZUP1-1", "uniprot_id": "KLRB1_MOUSE", "mass": 23909.0, "length": 214, "protein_name": "Killer cell lectin-like receptor subfamily B member 1", "gene_name": "Klrb1", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily B member 1", "refseq_ac": "NP_001093388", "gene_names_uniprotkb": "Klrb1; Gm4696; Klrb1d; Klrb1g; Klrb6; Nkrp1g", "gene_names_refseq": "100043861; 4930431A04Rik; Gm4696; Klrb1g; Klrb1; Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1; Killer cell lectin-like receptor subfamily B member 1G; Natural killer cell surface protein NKR-P1G; Natural killer lectin-like receptor 1E", "protein_names_refseq": "immunoreceptor NKR-P1G; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B member 1; lectin-like transmembrane protein Nkrp1g; lymphocyte antigen 55; natural killer cell surface protein NKR-P1G; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e", "tax_id": 10090, "disease": "", "pathway": " (mmu:100043861)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16751398;29263211", "class_list": "glycogene", "function": "In the spleen, Nkrp1g is selectively expressed by a subset of Natural Killer Cells, thereby potentially allowing for an inhibitory engagement with Clr-g-expressing activated Dendritic Cells during immune responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1A4F6", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0ZUP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q307W7-1", "uniprot_id": "KNCN_MOUSE", "mass": 12809.0, "length": 124, "protein_name": "Kinocilin", "gene_name": "Kncn", "organism": "Mouse", "refseq_name": "kinocilin isoform 2", "refseq_ac": "NP_001034213", "gene_names_uniprotkb": "Kncn; Kino", "gene_names_refseq": "Kino; Kncn; L5", "protein_names_uniprotkb": "Kinocilin", "protein_names_refseq": "kinocilin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:654462)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15855039", "class_list": "", "function": "May play a role in stabilizing dense microtubular networks or in vesicular trafficking., [UniProtKB]; We propose that kinocilin has a role in stabilizing dense microtubular networks or in vesicular trafficking. (Kinocilin), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0045177 apical part of cell;GO:0015630 microtubule cytoskeleton;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q307W7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3LS21-1", "uniprot_id": "KCNK9_MOUSE", "mass": 44911.0, "length": 402, "protein_name": "Potassium channel subfamily K member 9", "gene_name": "Kcnk9", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 9 precursor", "refseq_ac": "NP_001029048", "gene_names_uniprotkb": "Kcnk9; Task3", "gene_names_refseq": "A930009L07Rik; Kcnk9; Task3", "protein_names_uniprotkb": "Potassium channel subfamily K member 9; Acid-sensitive potassium channel protein TASK-3; TWIK-related acid-sensitive K(+) channel 3", "protein_names_refseq": "TWIK-related acid-sensitive K(+) channel 3; acid-sensitive potassium channel protein TASK-3; potassium channel subfamily K member 9 precursor", "tax_id": 10090, "disease": "Birk-Barel syndrome (Disease Ontology:DOID:0050675)", "pathway": " (mmu:223604); (R-MMU-1299316); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;16731510;16760342;16837582;17704508;17728447;18094244;18250325;28630209;30416196;36070380;37428352;37821107;38297831;38757583", "class_list": "", "function": "Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis., [RefSeq, PubMed]; Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment., [RefSeq, PubMed]; Inhibition by glucose in neurons is mediated by ion channels not previously implicated in central or peripheral glucose sensing: tandem-pore K(+) (K(2P)) channels, [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (By similarity). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (By similarity). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (PubMed:17728447, PubMed:18250325, PubMed:30416196). In granule neurons, hyperpolarizes the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, supports high-frequency action potential firing and increased neuronal excitability. Homomeric and/or heteromeric KCNK3:KCNK9 channels operate in cerebellar granule cells, whereas heteromeric KCNK1:KCNK9 enables currents in hippocampal dentate gyrus granule neurons (PubMed:17728447, PubMed:30416196). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex (PubMed:18094244). In retinal ganglion cells, mediates outward rectifying currents that regulate action potentials in response to acidification of the synaptic cleft. Involved in transmission of image-forming and nonimage-forming visual information in the retina (PubMed:36070380). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (PubMed:18250325, PubMed:28630209)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Kcnk9 gene is imprinted, with preferential expression from the maternal allele in mouse brain., [RefSeq, PubMed]; TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment., [RefSeq, PubMed]; TASK-like conductances are more prevalent in inhibitory interneurons than previously supposed., [RefSeq, PubMed]; TASK3 and HCN2 channels stabilize the membrane potential by a mutual functional interactions., [RefSeq, PubMed]; TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RT82", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007601 visual perception;GO:0006813 potassium ion transport;GO:0060075 regulation of resting membrane potential;GO:1990573 potassium ion import across plasma membrane;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3LS21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U410-1", "uniprot_id": "KLH21_MOUSE", "mass": 66547.0, "length": 597, "protein_name": "Kelch-like protein 21", "gene_name": "Klhl21", "organism": "Mouse", "refseq_name": "kelch-like protein 21", "refseq_ac": "NP_001028524", "gene_names_uniprotkb": "Klhl21", "gene_names_refseq": "1810045K06Rik; D330008A20; Klhl21; mKIAA0469", "protein_names_uniprotkb": "Kelch-like protein 21", "protein_names_refseq": "kelch-like protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:242785); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "27387502;28620047;31219806", "class_list": "", "function": "Data (including data from studies using cells cultured from knockout mice) suggest that Sccro neddylates Cul3 with Nedd8, promoting Cul3/Klhl21 complex formation and localization of Cul3 during telophase. (Sccro = squamous cell carcinoma-related oncogene; Cul3 = cullin 3; Nedd8 = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 = kelch-like protein 21), [RefSeq, PubMed]; Data clearly demonstrate that KLHL21 negatively regulates TNFalpha-activated NF-kappaB signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB regulation in cells., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AS70;Q3TZ30", "ec_number_list": "", "go_molecular_function": "GO:0097602 cullin family protein binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005827 polar microtubule;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0035853 chromosome passenger complex localization to spindle midzone;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U410-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3USL1-1", "uniprot_id": "KLDC9_MOUSE", "mass": 38185.0, "length": 350, "protein_name": "Kelch domain-containing protein 9", "gene_name": "Klhdc9", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 9", "refseq_ac": "NP_001028211", "gene_names_uniprotkb": "Klhdc9", "gene_names_refseq": "1190002J23Rik; ESTM31; Klhdc9", "protein_names_uniprotkb": "Kelch domain-containing protein 9", "protein_names_refseq": "kelch domain-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:68874)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVR4", "ec_number_list": "", "go_molecular_function": "GO:0030332 cyclin binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3USL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UWR2-1", "uniprot_id": "KHD1A_MOUSE", "mass": 19690.0, "length": 166, "protein_name": "KH homology domain-containing protein 1A", "gene_name": "Khdc1a", "organism": "Mouse", "refseq_name": "KH homology domain-containing protein 1A", "refseq_ac": "NP_899145", "gene_names_uniprotkb": "Khdc1a; Ndg1", "gene_names_refseq": "AU014713; C88118; Khdc1a; Ndg1", "protein_names_uniprotkb": "KH homology domain-containing protein 1A; Nur77 downstream gene 1 protein", "protein_names_refseq": "KH homology domain containing 1A; KH homology domain-containing protein 1A; Nur77 downstream protein 1; nur77 downstream gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:368204)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14657025;20668163", "class_list": "", "function": "Has pro-apoptotic activity., [UniProtKB, PubMed]; The paper describes the connection of this gene to translational machinery including CPEB, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNM0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UWR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M956-1", "uniprot_id": "KCTD1_MOUSE", "mass": 29405.0, "length": 257, "protein_name": "BTB/POZ domain-containing protein KCTD1", "gene_name": "Kctd1", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD1 isoform 2", "refseq_ac": "NP_598873", "gene_names_uniprotkb": "Kctd1", "gene_names_refseq": "4933402K10Rik; Kctd1", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD1; Potassium channel tetramerization domain-containing protein 1", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD1 isoform 2; BTB/POZ domain-containing protein KCTD1; potassium channel tetramerization domain containing 1", "tax_id": 10090, "disease": "scalp-ear-nipple syndrome (Disease Ontology:DOID:0111550)", "pathway": " (mmu:106931); (R-MMU-8866904)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21183079;21750661;28818080;31465887;33440155;39413138", "class_list": "", "function": "Is a regulator of different signaling pathways. Up-regulates ADCY5 thereby enhancing cAMP signaling, and is involved in the negative regulation of Wnt canonical, Hh and Notch signaling (By similarity). Is a repressor of transcriptional activation mediated by AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent (By similarity)., [UniProtKB, UniProtKB]; KCTD1 promotes adipogenesis through the interaction with transcription factor AP2 alpha and by removing it from the nucleus., [RefSeq, PubMed]; KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling., [RefSeq, PubMed]; Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron., [RefSeq, PubMed]; The main pathological phenotype of the Kctd1 (I27N) heterozygous mutant mice consists of kidney dysfunction and secondary effects thereof, without gross additional primary alterations in the other phenotypic parameters analyzed. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EER9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5M956-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60677-1", "uniprot_id": "ITAE_MOUSE", "mass": 128906.0, "length": 1167, "protein_name": "Integrin alpha-E", "gene_name": "Itgae", "organism": "Mouse", "refseq_name": "integrin alpha-E isoform 1 precursor", "refseq_ac": "NP_032425", "gene_names_uniprotkb": "Itgae", "gene_names_refseq": "A530055J10; CD103; Itgae; aM290; alpha-E1; alpha-M290", "protein_names_uniprotkb": "Integrin alpha-E; Integrin alpha M290", "protein_names_refseq": "integrin alpha M290; integrin alpha-E isoform 1 precursor; integrin alpha-E", "tax_id": 10090, "disease": "", "pathway": " (mmu:16407); (R-MMU-216083)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "30059200;34428180;7882170", "class_list": "", "function": "Integrin ITGAE/ITGB7 (alpha-E/beta-7) is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers., [UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "B1AUD5", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0008305 integrin complex;GO:0034691 integrin alphaE-beta7 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60677-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61738-1", "uniprot_id": "ITA7_MOUSE", "mass": 129329.0, "length": 1179, "protein_name": "Integrin alpha-7", "gene_name": "Itga7", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Itga7", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-7", "protein_names_refseq": "", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); muscular disease (Disease Ontology:DOID:0080000); congenital muscular dystrophy due to integrin alpha-7 deficiency (Disease Ontology:DOID:0110639); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); arteriosclerosis (Disease Ontology:DOID:2349)", "pathway": " (R-MMU-3000157); (R-MMU-3000178)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;1839357;18940796;19656770;21750661;25428506;30899004;31219806;34428180;35820727;37507081;37828378;7721841;8253814;8360188;8626012;8798472;9354797", "class_list": "", "function": "Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variability in different muscle types. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O88731;O88732;P70350;Q61737;Q61741", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0043236 laminin binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031594 neuromuscular junction;GO:0042383 sarcolemma;GO:0005927 muscle tendon junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0098609 cell-cell adhesion;GO:0048514 blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q61738-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXH9-1", "uniprot_id": "K2C73_MOUSE", "mass": 58911.0, "length": 539, "protein_name": "Keratin, type II cytoskeletal 73", "gene_name": "Krt73", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 73", "refseq_ac": "NP_997650", "gene_names_uniprotkb": "Krt73; Kb36", "gene_names_refseq": "CK-73; K73; Kb36; Krt73", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 73; CK-73; Cytokeratin-73; K73; Keratin-73; Type II inner root sheath-specific keratin-K6irs3; Type-II keratin Kb36", "protein_names_refseq": "cytokeratin-73; keratin, type II cytoskeletal 73; type II inner root sheath-specific keratin-K6irs3; type II keratin Kb36", "tax_id": 10090, "disease": "", "pathway": " (mmu:223915); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15085952;33822842;34428180;37507081;39627609;41018975", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NXH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFD6-1", "uniprot_id": "KI18B_MOUSE", "mass": 91936.0, "length": 834, "protein_name": "Kinesin-like protein KIF18B", "gene_name": "Kif18b", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF18B", "refseq_ac": "NP_932063", "gene_names_uniprotkb": "Kif18b", "gene_names_refseq": "3000004C01Rik; Kif18b", "protein_names_uniprotkb": "Kinesin-like protein KIF18B", "protein_names_refseq": "N-8 kinesin; kinesin-like protein KIF18B", "tax_id": 10090, "disease": "", "pathway": " (mmu:70218); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "25428506;28135057;31219806;31599954;34432485;35820727", "class_list": "", "function": "In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity)., [UniProtKB]; KIF18B is a cell type-specific regulator of spindle orientation in the epidermis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0T0;Q80V20", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0000235 astral microtubule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PFD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPS0-1", "uniprot_id": "KS6A6_MOUSE", "mass": 86571.0, "length": 764, "protein_name": "Ribosomal protein S6 kinase alpha-6", "gene_name": "Rps6ka6", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase alpha-6 isoform 1", "refseq_ac": "NP_080225", "gene_names_uniprotkb": "Rps6ka6", "gene_names_refseq": "2610524K04Rik; RSK4; Rps6ka6; S6K-alpha-6", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-6; 2.7.11.1; S6K-alpha-6", "protein_names_refseq": "ribosomal protein S6 kinase alpha-6 isoform 1; ribosomal protein S6 kinase alpha-6; ribosomal protein S6 kinase polypeptide 6", "tax_id": 10090, "disease": "Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (mmu:67071); (R-MMU-442742); (R-MMU-444257)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15121846;21183079;21750661;22872234;29684350;34203471;34428180;38577978", "class_list": "", "function": "Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis., [UniProtKB, PubMed]; Rsk4 inhibits the transcriptional activation of specific targets of receptor tyrosine kinase signaling as well as the activation of ERK, [RefSeq, PubMed]; TRAF4 knockdown significantly inhibited proliferation, invasion and metastasis in the xenograft nude mouse model, possibly involving in the interaction with RSK4., [RefSeq, PubMed]; Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWZ2;Q9CUR6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0038202 TORC1 signaling;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:2000381 negative regulation of mesoderm development;GO:0045992 negative regulation of embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TPS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSU7-1", "uniprot_id": "KIRR2_MOUSE", "mass": 74529.0, "length": 700, "protein_name": "Kin of IRRE-like protein 2", "gene_name": "Kirrel2", "organism": "Mouse", "refseq_name": "kin of IRRE-like protein 2 precursor", "refseq_ac": "NP_766486", "gene_names_uniprotkb": "Kirrel2; Neph3", "gene_names_refseq": "C330019F22Rik; Kirrel2; NEPH3; NLG1", "protein_names_uniprotkb": "Kin of IRRE-like protein 2; Kin of irregular chiasm-like protein 2", "protein_names_refseq": "X kin of IRRE like 2; kin of IRRE-like protein 2 precursor; kin of IRRE-like protein 2; kin of irregular chiasm-like 2; kin of irregular chiasm-like protein 2", "tax_id": 10090, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:243911); (R-MMU-373753)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12424224;12837264;19887377;21750661;26324709;31142543;34731636", "class_list": "", "function": "Kirrel2 is required for axonal coalescence in subsets of Olfactory sensory neurons that project axons to the DII (dorsal) region; Kirrel2/3-independent mechanisms also control olfactory sensory neurons axonal coalescence in certain regions of the Olfactory bulb. Publication Status: Online-Only, [RefSeq, PubMed]; May regulate basal insulin secretion., [UniProtKB, PubMed]; Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9343, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ98", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0034451 centriolar satellite;GO:0036057 slit diaphragm", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7TSU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W68-1", "uniprot_id": "KIRR1_MOUSE", "mass": 87176.0, "length": 789, "protein_name": "Kin of IRRE-like protein 1", "gene_name": "Kirrel1", "organism": "Mouse", "refseq_name": "kin of IRRE-like protein 1 isoform 1 precursor", "refseq_ac": "NP_001164456", "gene_names_uniprotkb": "Kirrel1; Kirrel; Neph1", "gene_names_refseq": "6720469N11Rik; Kirrel1; Kirrel; Neph1", "protein_names_uniprotkb": "Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1", "protein_names_refseq": "kin of IRRE like 1; kin of IRRE-like protein 1 isoform 1 precursor; kin of IRRE-like protein 1; kin of irregular chiasm-like protein 1; nephrin 1; nephrin-like protein 1", "tax_id": 10090, "disease": "nephrotic syndrome type 23 (Disease Ontology:DOID:0112266); nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:170643); (R-MMU-373753)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11416156;12424224;12538735;12660326;12865409;19349973;25428506;29717104;34391780;34887587;37828378", "class_list": "", "function": "Analysis of five promoter-reporter gene constructs showed that regulatory elements driving expression encoded by exon 1A in kidney and brain are localized in region between -4 kb and 2.1 kb., [RefSeq, PubMed]; KIRREL was overexpressed in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair., [RefSeq, PubMed]; Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:11416156). Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIJ4;Q8CJ59;Q923L4", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0043198 dendritic shaft;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0097017 renal protein absorption;GO:0001933 negative regulation of protein phosphorylation;GO:0098609 cell-cell adhesion;GO:0030838 positive regulation of actin filament polymerization;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q80W68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGY4-1", "uniprot_id": "KLH26_MOUSE", "mass": 67031.0, "length": 606, "protein_name": "Kelch-like protein 26", "gene_name": "Klhl26", "organism": "Mouse", "refseq_name": "kelch-like protein 26 isoform 3", "refseq_ac": "NP_001116302", "gene_names_uniprotkb": "Klhl26", "gene_names_refseq": "C630013N10Rik; Klhl26; Klkl26", "protein_names_uniprotkb": "Kelch-like protein 26", "protein_names_refseq": "kelch-like protein 26 isoform 3; kelch-like protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:234378)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "May play a role in endo(sarco)plasmic reticulum (ER/SR) mitochondrial signaling (By similarity). May be part of the ubiquitin-proteasome system (UPS) and affect ubiquitination and degradation of target substrates in cardiomyocytes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIG6;Q8R153", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRB7-1", "uniprot_id": "KAT6B_MOUSE", "mass": 208526.0, "length": 1872, "protein_name": "Histone acetyltransferase KAT6B", "gene_name": "Kat6b", "organism": "Mouse", "refseq_name": "histone acetyltransferase KAT6B isoform 1", "refseq_ac": "NP_059507", "gene_names_uniprotkb": "Kat6b; Myst4", "gene_names_refseq": "B130044K16Rik; Kat6b; MYST-4; Morf; Myst4; mKIAA0383; qkf; querkopf", "protein_names_uniprotkb": "Histone acetyltransferase KAT6B; 2.3.1.48; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MYST-4; Protein querkopf", "protein_names_refseq": "MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MYST histone acetyltransferase monocytic leukemia 4; histone acetyltransferase KAT6B isoform 1; histone acetyltransferase KAT6B; histone acetyltransferase MYST4; histone acetyltransferase querkopf; monocytic leukemia; protein querkopf", "tax_id": 10090, "disease": "Ohdo syndrome, SBBYS variant (Disease Ontology:DOID:0060290); leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); bipolar disorder (Disease Ontology:DOID:3312); Noonan syndrome (Disease Ontology:DOID:3490)", "pathway": " (mmu:54169); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10821753;11782361;21750661;22077973;23806337;31219806;34428180;34678516;36210013;36852467", "class_list": "", "function": "Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors., [RefSeq, PubMed]; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). Involved in cerebral cortex development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QK86;Q7TNW5;Q8BG35;Q8C441;Q9JKX5", "ec_number_list": "2.3.1.48;2.3.1.-;2.7.11.1;2.3.1.259;2.3.1.57;2.3.1.80;4.2.1.-", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0070776 MOZ/MORF histone acetyltransferase complex;GO:0000786 nucleosome", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BRB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRG6-1", "uniprot_id": "KLH24_MOUSE", "mass": 68364.0, "length": 600, "protein_name": "Kelch-like protein 24", "gene_name": "Klhl24", "organism": "Mouse", "refseq_name": "kelch-like protein 24", "refseq_ac": "NP_083712", "gene_names_uniprotkb": "Klhl24", "gene_names_refseq": "1110046J11Rik; 4930429H24Rik; 6530402O20Rik; Klhl24", "protein_names_uniprotkb": "Kelch-like protein 24; KRIP6; Kainate receptor-interacting protein for GluR6", "protein_names_refseq": "KRIP6; kainate receptor-interacting protein for GluR6; kelch-like protein 24", "tax_id": 10090, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (mmu:75785)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18250455;20173027;21750661;25428507;27798626;27802388;30084848;30779550;31599954;34428180;35066002;35984892;36716923", "class_list": "", "function": "Controls KRT14 levels during keratinocytes differentiation (PubMed:27798626). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Excess KLHL24 Impairs Skin Wound Healing through the Degradation of Vimentin., [RefSeq, PubMed]; KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQG0;Q78J30;Q8BQU1;Q9D5K3", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0030424 axon;GO:0043204 perikaryon;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045109 intermediate filament organization;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BRG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSF5-1", "uniprot_id": "KLH38_MOUSE", "mass": 65651.0, "length": 581, "protein_name": "Kelch-like protein 38", "gene_name": "Klhl38", "organism": "Mouse", "refseq_name": "kelch-like protein 38", "refseq_ac": "NP_808423", "gene_names_uniprotkb": "Klhl38", "gene_names_refseq": "8230402K04Rik; Klhl38", "protein_names_uniprotkb": "Kelch-like protein 38", "protein_names_refseq": "kelch-like protein 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:268807)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35112472", "class_list": "", "function": "KLHL38 facilitates staurosporine-induced apoptosis in HL-1 cells via myocardin degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BSF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3F7-1", "uniprot_id": "KLH30_MOUSE", "mass": 64605.0, "length": 581, "protein_name": "Kelch-like protein 30", "gene_name": "Klhl30", "organism": "Mouse", "refseq_name": "kelch-like protein 30", "refseq_ac": "NP_081827", "gene_names_uniprotkb": "Klhl30", "gene_names_refseq": "4631423F02Rik; Klhl30", "protein_names_uniprotkb": "Kelch-like protein 30", "protein_names_refseq": "kelch-like protein 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:70788)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D692", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C3F7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4X2-1", "uniprot_id": "KC1G3_MOUSE", "mass": 48938.0, "length": 424, "protein_name": "Casein kinase I isoform gamma-3", "gene_name": "Csnk1g3", "organism": "Mouse", "refseq_name": "casein kinase I isoform gamma-3", "refseq_ac": "NP_690022", "gene_names_uniprotkb": "Csnk1g3", "gene_names_refseq": "3300002K07Rik; C330049O21Rik; Csnk1g3", "protein_names_uniprotkb": "Casein kinase I isoform gamma-3; 2.7.11.1; CKI-gamma 3", "protein_names_refseq": "CKI-gamma 3; casein kinase I isoform gamma-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70425)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15782199;16014721;19144319;21183079;21750661;31801942;34428180;36210013", "class_list": "", "function": "Casein kinase-1gamma1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Regulates fast synaptic transmission mediated by glutamate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM57;Q8C001;Q8K079", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0046777 protein autophosphorylation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C4X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCX5-1", "uniprot_id": "KT222_MOUSE", "mass": 34198.0, "length": 294, "protein_name": "Keratin-like protein KRT222", "gene_name": "Krt222", "organism": "Mouse", "refseq_name": "keratin-like protein KRT222 isoform 1", "refseq_ac": "NP_766534", "gene_names_uniprotkb": "Krt222", "gene_names_refseq": "6330509G02Rik; Krt222", "protein_names_uniprotkb": "Keratin-like protein KRT222; Keratin-222", "protein_names_refseq": "keratin-like protein KRT222 isoform 1; keratin-like protein KRT222", "tax_id": 10090, "disease": "", "pathway": " (mmu:268481)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU52;Q68FD8", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CCX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFA7-1", "uniprot_id": "KLF17_MOUSE", "mass": 38076.0, "length": 341, "protein_name": "Krueppel-like factor 17", "gene_name": "Klf17", "organism": "Mouse", "refseq_name": "Krueppel-like factor 17", "refseq_ac": "NP_083692", "gene_names_uniprotkb": "Klf17; Gzf; Zfp393; Znf393", "gene_names_refseq": "7420700M05Rik; D4Ertd561e; Gzf; Klf17; Zfp393", "protein_names_uniprotkb": "Krueppel-like factor 17; Germ cell-specific zinc finger protein; Zinc finger protein 393", "protein_names_refseq": "Krueppel-like factor 17; Kruppel-like factor 17; germ cell specific zinc finger protein; zinc finger protein 393", "tax_id": 10090, "disease": "", "pathway": " (mmu:75753)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12351194;19801974;35391627;38325372", "class_list": "", "function": "Demonstrate that KLF17 expression is significantly downregulated in primary human breast cancer samples and that the combined expression pattern of KLF17 and Id1 can serve as a potential biomarker for lymph node metastasis in breast cancer, [RefSeq, PubMed]; KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2., [RefSeq, PubMed]; Maternal KLF17 controls zygotic genome activation by acting as a messenger for RNA Pol II recruitment in mouse embryos., [RefSeq, PubMed]; Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development., [UniProtKB, PubMed]; ZFP393 functions as a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ASI5;Q3UT30;Q6P233;Q9D351", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CFA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1C0-1", "uniprot_id": "KCNC4_MOUSE", "mass": 68655.0, "length": 628, "protein_name": "Voltage-gated potassium channel KCNC4", "gene_name": "Kcnc4", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel KCNC4 isoform 2", "refseq_ac": "NP_666034", "gene_names_uniprotkb": "Kcnc4", "gene_names_refseq": "KSHIIIC; Kcnc4; Kcr2-4; Kv3.4", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC4; Potassium voltage-gated channel subfamily C member 4; Voltage-gated potassium channel subunit Kv3.4", "protein_names_refseq": "potassium voltage-gated channel subfamily C member 4; voltage-gated potassium channel KCNC4 isoform 2; voltage-gated potassium channel KCNC4; voltage-gated potassium channel subunit Kv3.4", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:99738); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28390823;33032555;40885482", "class_list": "", "function": "Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice. Publication Status: Online-Only, [RefSeq, PubMed]; KV3.4 channel subunits are precociously upregulated in cultured astrocytes exposed to Ab oligomers., [RefSeq, PubMed]; Voltage-gated potassium channel that opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005249 voltage-gated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0046928 regulation of neurotransmitter secretion;GO:1904456 negative regulation of neuronal action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R1C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R574-1", "uniprot_id": "KPRB_MOUSE", "mass": 40881.0, "length": 369, "protein_name": "Phosphoribosyl pyrophosphate synthase-associated protein 2", "gene_name": "Prpsap2", "organism": "Mouse", "refseq_name": "phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a", "refseq_ac": "NP_001157714", "gene_names_uniprotkb": "Prpsap2", "gene_names_refseq": "A230054F23Rik; PAP41; Prpsap2", "protein_names_uniprotkb": "Phosphoribosyl pyrophosphate synthase-associated protein 2; 41 kDa phosphoribosypyrophosphate synthetase-associated protein; PAP41; PRPP synthase-associated protein 2", "protein_names_refseq": "41 kDa phosphoribosypyrophosphate synthetase-associated protein; PRPP synthase-associated protein 2; PRPP synthetase-associated protein 2; phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a; phosphoribosyl pyrophosphate synthase-associated protein 2", "tax_id": 10090, "disease": "X-linked nonsyndromic deafness (Disease Ontology:DOID:0050566); Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210)", "pathway": " (mmu:212627)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;22872234;31219806;34428180;35820727", "class_list": "", "function": "Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060348 bone development;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCK5-1", "uniprot_id": "KLH20_MOUSE", "mass": 67412.0, "length": 604, "protein_name": "Kelch-like protein 20", "gene_name": "Klhl20", "organism": "Mouse", "refseq_name": "kelch-like protein 20", "refseq_ac": "NP_001034571", "gene_names_uniprotkb": "Klhl20; Kiaa4210; Kleip", "gene_names_refseq": "D930050H05Rik; Kleip; Klhl20; mKIAA4210", "protein_names_uniprotkb": "Kelch-like protein 20; Kelch-like ECT2-interacting protein", "protein_names_refseq": "Kelch-like ECT2 interacting protein; kelch-like ECT2-interacting protein; kelch-like protein 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:226541); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "22511632;25428506;26687681;30016717;30084848;35820727", "class_list": "", "function": "KLEIP is an important molecule regulating corneal epithelial integrity Publication Status: Online-Only, [RefSeq, PubMed]; Study identifies a key role of Cul3-KLHL20 in autophagy termination by controlling autophagy-dependent turnover of ULK1 and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTH3;Q8BWA2", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0019964 type II interferon binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VCK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCP8-1", "uniprot_id": "KAD6_MOUSE", "mass": 19947.0, "length": 172, "protein_name": "Adenylate kinase isoenzyme 6", "gene_name": "Ak6", "organism": "Mouse", "refseq_name": "adenylate kinase isoenzyme 6", "refseq_ac": "NP_081868", "gene_names_uniprotkb": "Ak6; Cinap", "gene_names_refseq": "2810046E22Rik; 4921516M08Rik; AK/ATPase; Ak6", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 6; 2.7.4.3; AK/ATPase; AK6; Coilin-interacting nuclear ATPase protein; Dual activity adenylate kinase/ATPase", "protein_names_refseq": "ATP-AMP transphosphorylase 6; adenylate kinase isoenzyme 6; coilin-interacting nuclear ATPase protein; dual activity adenylate kinase/ATPase", "tax_id": 10090, "disease": "", "pathway": " (mmu:102216272); (R-MMU-499943)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18299400;19224205;20173027;21750661;21952136;25428506;25428507;34428180;35820727", "class_list": "", "function": "Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;2.7.4.6;2.7.4.4;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;2.7.4.3;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.14", "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004140 dephospho-CoA kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis;GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VCP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V45-1", "uniprot_id": "KISSR_MOUSE", "mass": 43061.0, "length": 396, "protein_name": "KiSS-1 receptor", "gene_name": "Kiss1r", "organism": "Mouse", "refseq_name": "kiSS-1 receptor isoform 1", "refseq_ac": "NP_444474", "gene_names_uniprotkb": "Kiss1r; Gpr54", "gene_names_refseq": "Gpr54; KiSS-1; Kiss1r; kiSS-1R", "protein_names_uniprotkb": "KiSS-1 receptor; G protein-coupled receptor 54; G protein-coupled receptor OT7T175; KiSS-1R; Kisspeptins receptor; Metastin receptor; mOT7T175", "protein_names_refseq": "G-protein coupled receptor 54; G-protein coupled receptor OT7T175; kiSS-1 receptor isoform 1; kiSS-1 receptor; kisspeptins receptor; metastin receptor; orphan G protein-coupled receptor 54", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 8 with or without anosmia (Disease Ontology:DOID:0090074); central precocious puberty 1 (Disease Ontology:DOID:0112310); breast cancer (Disease Ontology:DOID:1612); hypogonadism (Disease Ontology:DOID:1924); transitional cell carcinoma (Disease Ontology:DOID:2671); papillary carcinoma (Disease Ontology:DOID:3113)", "pathway": " (mmu:114229); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11414709;12359743;14573733;14652023;15519892;15665093;18434521;18483150;25147978;38346942;38976640", "class_list": "", "function": "Mutations in GPR54 cause autosomal recessive idiopathic hypogonadotropic hypogonadism in humans and mice, suggesting that this receptor is essential for normal gonadotropin-releasing hormone physiology and for puberty., [RefSeq, PubMed]; Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54) (PubMed:12359743). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:14573733, PubMed:14652023, PubMed:15665093). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (PubMed:18434521, PubMed:18483150). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (PubMed:25147978). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (PubMed:38346942). KISS1R is also involved in the regulation of other processes, including cell proliferation and cell migration (PubMed:12359743)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features., [RefSeq, PubMed]; The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3P2", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91V45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WD7-1", "uniprot_id": "KI18A_MOUSE", "mass": 100935.0, "length": 886, "protein_name": "Kinesin-like protein KIF18A", "gene_name": "Kif18a", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF18A isoform 1", "refseq_ac": "NP_647464", "gene_names_uniprotkb": "Kif18a", "gene_names_refseq": "B130001M12Rik; Kif18a; gcd2", "protein_names_uniprotkb": "Kinesin-like protein KIF18A", "protein_names_refseq": "N-8 kinesin; kinesin superfamily protein 18A; kinesin-like protein KIF18A isoform 1; kinesin-like protein KIF18A", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:228421); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-6811434); (R-MMU-68877); (R-MMU-9648025); (R-MMU-983189)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "31677127;34515734", "class_list": "", "function": "Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis., [RefSeq, PubMed]; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression (By similarity)., [UniProtKB]; Phylogenetic analysis revealed that the KIF18A gene family is remarkably conserved across vertebrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP77;Q8BLL1", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005871 kinesin complex", "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement;GO:0072520 seminiferous tubule development;GO:0007140 male meiotic nuclear division;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JB0-1", "uniprot_id": "KLF7_MOUSE", "mass": 33337.0, "length": 301, "protein_name": "Krueppel-like factor 7", "gene_name": "Klf7", "organism": "Mouse", "refseq_name": "Krueppel-like factor 7", "refseq_ac": "NP_291041", "gene_names_uniprotkb": "Klf7", "gene_names_refseq": "9830124P08Rik; Klf7", "protein_names_uniprotkb": "Krueppel-like factor 7", "protein_names_refseq": "Krueppel-like factor 7; Kruppel-like factor 7 (ubiquitous)", "tax_id": 10090, "disease": "", "pathway": " (mmu:93691)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11245580;11336497;14729953;15937222;15964824;21750661;28916725;34428180;38184286", "class_list": "", "function": "Klf7 gene ablation reduces TrkA expression in sensory neurons due to effect on cell death, [RefSeq, PubMed]; MiR-520f-3p blocks MNNG-induced gastric precancerous lesions via the KLF7/NFkappaB pathway., [RefSeq, PubMed]; Transcriptional factor (PubMed:11245580). Plays a critical role in neuronal morphogenesis (PubMed:11336497, PubMed:15964824). Represses the corneal epithelium differentiation (By similarity). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99P62", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99JB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR40-1", "uniprot_id": "KLH28_MOUSE", "mass": 64125.0, "length": 571, "protein_name": "Kelch-like protein 28", "gene_name": "Klhl28", "organism": "Mouse", "refseq_name": "kelch-like protein 28", "refseq_ac": "NP_079983", "gene_names_uniprotkb": "Klhl28; Btbd5", "gene_names_refseq": "2810440N09Rik; 4122402F11Rik; 4931401E10Rik; Btbd5; Klhl28", "protein_names_uniprotkb": "Kelch-like protein 28; BTB/POZ domain-containing protein 5", "protein_names_refseq": "BTB (POZ) domain containing 5; BTB/POZ domain-containing protein 5; kelch-like protein 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:66689)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;30084848;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYV0", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CUL5-1", "uniprot_id": "DRC11_MOUSE", "mass": 99875.0, "length": 857, "protein_name": "Dynein regulatory complex subunit 11", "gene_name": "Drc11; Iqca1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Drc11; Iqca1; Iqca1; Iqca", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein regulatory complex subunit 11; IQ and AAA domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT65;Q9D4P1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CUL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3V1-1", "uniprot_id": "DRC10_MOUSE", "mass": 53351.0, "length": 458, "protein_name": "Dynein regulatory complex subunit 10", "gene_name": "Drc10", "organism": "Mouse", "refseq_name": "dynein regulatory complex subunit 10", "refseq_ac": "NP_083684", "gene_names_uniprotkb": "Drc10; Iqcd", "gene_names_refseq": "4933433C09Rik; Drc10; Iqcd", "protein_names_uniprotkb": "Dynein regulatory complex subunit 10; IQ domain-containing protein D", "protein_names_refseq": "IQ domain-containing protein D; dynein regulatory complex protein 10; dynein regulatory complex subunit 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:75732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497P6;Q8C5X0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036064 ciliary basal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D3V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D618-1", "uniprot_id": "KBTBC_MOUSE", "mass": 71191.0, "length": 625, "protein_name": "Kelch repeat and BTB domain-containing protein 12", "gene_name": "Kbtbd12", "organism": "Mouse", "refseq_name": "kelch repeat and BTB domain-containing protein 12", "refseq_ac": "NP_001265600", "gene_names_uniprotkb": "Kbtbd12; Klhdc6", "gene_names_refseq": "4833415F11Rik; 4933428M03Rik; Kbtbd12; Klhdc6", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 12; Kelch domain-containing protein 6", "protein_names_refseq": "kelch domain containing 6; kelch repeat and BTB domain-containing protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:74589)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJU5", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D618-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D892-1", "uniprot_id": "ITPA_MOUSE", "mass": 21897.0, "length": 198, "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "Itpa", "organism": "Mouse", "refseq_name": "inosine triphosphate pyrophosphatase isoform 1", "refseq_ac": "NP_080198", "gene_names_uniprotkb": "Itpa", "gene_names_refseq": "2010016I08Rik; ITPase; Itpa; Itp; NTPase", "protein_names_uniprotkb": "Inosine triphosphate pyrophosphatase; 3.6.1.66; ITPase; Inosine triphosphatase; NTPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; XTP/dITP diphosphatase", "protein_names_refseq": "XTP/dITP diphosphatase; inosine triphosphate pyrophosphatase isoform 1; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; nucleoside triphosphate pyrophosphatase; nucleoside-triphosphate diphosphatase", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 35 (Disease Ontology:DOID:0080458); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); anemia (Disease Ontology:DOID:2355); hemolytic anemia (Disease Ontology:DOID:583); rheumatoid arthritis (Disease Ontology:DOID:7148); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:16434); (R-MMU-74259); (R-MMU-9755088)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "17090528;20081199;20601097;21183079;27618981;33208550;37507081", "class_list": "", "function": "Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, PubMed, HAMAP, PubMed, PubMed]; The authors analysed ITPA-deficient human and mouse cells, and revealed that ITPA deficiency induces MLH1/PMS2- and p53-dependent growth arrest and DNA instability in mammalian cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0Q8", "ec_number_list": "3.6.1.66", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0035870 dITP diphosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009143 nucleoside triphosphate catabolic process;GO:0051276 chromosome organization;GO:0006193 ITP catabolic process;GO:0009204 deoxyribonucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA16-1", "uniprot_id": "IZUM2_MOUSE", "mass": 24868.0, "length": 220, "protein_name": "Izumo sperm-egg fusion protein 2", "gene_name": "Izumo2", "organism": "Mouse", "refseq_name": "izumo sperm-egg fusion protein 2 isoform 1 precursor", "refseq_ac": "NP_083593", "gene_names_uniprotkb": "Izumo2", "gene_names_refseq": "1700023D19Rik; Izumo2", "protein_names_uniprotkb": "Izumo sperm-egg fusion protein 2", "protein_names_refseq": "izumo sperm-egg fusion protein 2 isoform 1 precursor; izumo sperm-egg fusion protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75510); (R-MMU-1300645)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19658160;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5Z2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DA16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL16-1", "uniprot_id": "ISG20_MOUSE", "mass": 32503.0, "length": 300, "protein_name": "Interferon-stimulated gene 20 kDa protein", "gene_name": "Isg20", "organism": "Mouse", "refseq_name": "interferon-stimulated gene 20 kDa protein isoform b", "refseq_ac": "NP_001106999", "gene_names_uniprotkb": "Isg20", "gene_names_refseq": "1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL; HEM45; Isg20", "protein_names_uniprotkb": "Interferon-stimulated gene 20 kDa protein; 3.1.13.1; Promyelocytic leukemia nuclear body-associated protein ISG20; Protein DnaQL", "protein_names_refseq": "interferon stimulated exonuclease; interferon-stimulated gene 20 kDa protein isoform b; interferon-stimulated gene 20 kDa protein; promyelocytic leukemia nuclear body-associated protein ISG20", "tax_id": 10090, "disease": "", "pathway": " (mmu:57444)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19321657;21750661;30232164;31219806;31599954;31600344;37452495", "class_list": "", "function": "ISG20 upregulated IFIT1 genes and inhibited translation of the alphavirus genome. Furthermore, IFIT1-sensitive alphavirus replication was increased in Isg20(-/-) mice compared to the replication of wild-type viruses but not in cells ectopically expressing ISG20. Publication Status: Online-Only, [RefSeq, PubMed]; Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA. Inhibition of several viruses does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (PubMed:30232164). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies (PubMed:31600344). May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (PubMed:30232164). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Suggest that the recruitment of peripheral CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance., [RefSeq, PubMed]; Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CPZ5", "ec_number_list": "", "go_molecular_function": "GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0008859 exoribonuclease II activity;GO:0030620 U2 snRNA binding;GO:0046872 metal ion binding;GO:0004527 exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0016605 PML body", "go_biological_process": "GO:0006396 RNA processing;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JL16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXL2-1", "uniprot_id": "KI21A_MOUSE", "mass": 186536.0, "length": 1672, "protein_name": "Kinesin-like protein KIF21A", "gene_name": "Kif21a", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF21A isoform 1", "refseq_ac": "NP_001102510", "gene_names_uniprotkb": "Kif21a; Kiaa1708", "gene_names_refseq": "Kif21a", "protein_names_uniprotkb": "Kinesin-like protein KIF21A", "protein_names_refseq": "N-5 kinesin; kinesin-like protein KIF21A isoform 1; kinesin-like protein KIF21A", "tax_id": 10090, "disease": "congenital fibrosis of the extraocular muscles (Disease Ontology:DOID:0080143); congenital fibrosis of the extraocular muscles 1 (Disease Ontology:DOID:0081015)", "pathway": " (mmu:16564); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10225949;17242355;21183079;21750661;25428506;29217769;30059200;30084848;33300544;34274317", "class_list": "", "function": "Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A., [RefSeq, PubMed]; Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5H1;Q6ZPJ8;Q8BWZ9;Q8BXF1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005938 cell cortex;GO:0030425 dendrite", "go_biological_process": "GO:1902667 regulation of axon guidance;GO:0031113 regulation of microtubule polymerization;GO:0007018 microtubule-based movement;GO:0008089 anterograde axonal transport;GO:0043622 cortical microtubule organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0Y5-1", "uniprot_id": "KAD1_MOUSE", "mass": 21540.0, "length": 194, "protein_name": "Adenylate kinase isoenzyme 1", "gene_name": "Ak1", "organism": "Mouse", "refseq_name": "adenylate kinase isoenzyme 1 isoform 2", "refseq_ac": "NP_001185719", "gene_names_uniprotkb": "Ak1", "gene_names_refseq": "Ak-1; Ak1; B430205N08Rik", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 1; 2.7.4.3; 2.7.4.4; 2.7.4.6; AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase", "protein_names_refseq": "adenylate kinase isoenzyme 1 isoform 2; cytosolic adenylate kinase", "tax_id": 10090, "disease": "congenital nonspherocytic hemolytic anemia 3 (Disease Ontology:DOID:0051004); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); middle cerebral artery infarction (Disease Ontology:DOID:3525); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11636); (R-MMU-499943)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10557075;16452087;16790685;21183079;21750661;32744313;33300544;34192805;36288343;36804949;37507081;39927985", "class_list": "", "function": "Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity., [RefSeq, PubMed]; Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stressdagger., [RefSeq, PubMed]; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)., [UniProtKB, UniProtKB, HAMAP, UniProtKB]; The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AK80;Q542C5;Q9R0Y4", "ec_number_list": "2.7.4.6;2.7.4.4;3.1.11.-;2.7.11.1;2.7.13.3;2.7.4.18;3.1.24.-;2.7.4.3;2.7.4.14", "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0047506 dAMP kinase activity;GO:0019205 nucleobase-containing compound kinase activity", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046103 inosine biosynthetic process;GO:0046034 ATP metabolic process;GO:2000045 regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9R0Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHF9-1", "uniprot_id": "LY96_MOUSE", "mass": 18394.0, "length": 160, "protein_name": "Lymphocyte antigen 96", "gene_name": "Ly96", "organism": "Mouse", "refseq_name": "lymphocyte antigen 96 isoform B precursor", "refseq_ac": "NP_001153183", "gene_names_uniprotkb": "Ly96; Esop1; Md2", "gene_names_refseq": "ESOP-1; Ly96; MD-2; MD2", "protein_names_uniprotkb": "Lymphocyte antigen 96; ESOP-1; Ly-96; Protein MD-2", "protein_names_refseq": "ly-96; lymphocyte antigen 96 isoform B precursor; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17087); (R-MMU-140534); (R-MMU-166016); (R-MMU-166166); (R-MMU-2562578); (R-MMU-5686938); (R-MMU-936964); (R-MMU-937041); (R-MMU-937072); (R-MMU-9707616); (R-MMU-975163); (R-MMU-9824878)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10725698;10891475;11884465;17803912;20133493;21750661;22532668;24380872;36115635;36698311", "class_list": "", "function": "Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis., [RefSeq, PubMed]; Heme induces inflammatory injury by directly binding to the complex of myeloid differentiation protein 2 and toll-like receptor 4., [RefSeq, PubMed]; MD-2 in complex with toll-like receptor 4 mediates signal transduction induced by the amino acid-containing bacterial lipid, flavolipin. Erratum:[J Immunol 2002 May 15;168(10):5376], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0035662 Toll-like receptor 4 binding;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0046696 lipopolysaccharide receptor complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0071222 cellular response to lipopolysaccharide;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JHF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53776-1", "uniprot_id": "LHX4_MOUSE", "mass": 43078.0, "length": 390, "protein_name": "LIM/homeobox protein Lhx4", "gene_name": "Lhx4", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx4", "refseq_ac": "NP_034842", "gene_names_uniprotkb": "Lhx4; Gsh-4; Gsh4", "gene_names_refseq": "A330062J17Rik; Gsh-4; Gsh4; Lhx4", "protein_names_uniprotkb": "LIM/homeobox protein Lhx4; LIM homeobox protein 4", "protein_names_refseq": "LIM homeo box protein 4; LIM/homeobox protein Lhx4", "tax_id": 10090, "disease": "combined pituitary hormone deficiency 4 (Disease Ontology:DOID:0061017); combined pituitary hormone deficiency (Disease Ontology:DOID:9410)", "pathway": " (mmu:16872)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;32937137;38970652;7913017;9286712", "class_list": "", "function": "LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes., [RefSeq, PubMed]; Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons. Publication Status: Online-Only, [RefSeq, PubMed]; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08916;Q810K7;Q9R280", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008327 methyl-CpG binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59481-1", "uniprot_id": "LMA2L_MOUSE", "mass": 39881.0, "length": 347, "protein_name": "VIP36-like protein", "gene_name": "Lman2l", "organism": "Mouse", "refseq_name": "VIP36-like protein isoform 2 precursor", "refseq_ac": "NP_001013392", "gene_names_uniprotkb": "Lman2l; Vipl", "gene_names_refseq": "A630028F14Rik; Lman2l; VIP36-like; VIPL", "protein_names_uniprotkb": "VIP36-like protein; LMAN2-like protein; Lectin mannose-binding 2-like", "protein_names_refseq": "LMAN2-like protein; VIP36-like protein isoform 2 precursor", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 69 (Disease Ontology:DOID:0061042); autosomal recessive intellectual developmental disorder 52 (Disease Ontology:DOID:0081215)", "pathway": " (mmu:214895); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;40997131", "class_list": "glycogene", "function": "May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ91", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005537 D-mannose binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P59481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04945-1", "uniprot_id": "KV6AB_MOUSE", "mass": 11713.0, "length": 108, "protein_name": "Ig kappa chain V-VI region NQ2-6.1", "gene_name": "Igkv4-55", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Igkv4-55", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-VI region NQ2-6.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;6877353", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04945-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01632-1", "uniprot_id": "KV1A1_MOUSE", "mass": 12717.0, "length": 114, "protein_name": "Ig kappa chain V-I region S107A", "gene_name": "Igkv7-33", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Igkv7-33", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-I region S107A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "21750661;3141511;34428180;6788890", "class_list": "", "function": "Anti-phosphocholine antibody., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3Y4-1", "uniprot_id": "KNTC1_MOUSE", "mass": 250358.0, "length": 2207, "protein_name": "Kinetochore-associated protein 1", "gene_name": "Kntc1", "organism": "Mouse", "refseq_name": "kinetochore-associated protein 1", "refseq_ac": "NP_001035886", "gene_names_uniprotkb": "Kntc1; Kiaa0166", "gene_names_refseq": "D330012D13; Kntc1; jgl", "protein_names_uniprotkb": "Kinetochore-associated protein 1", "protein_names_refseq": "kinetochore-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:208628); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "21750661;22872234;25428506;26495903;30084848;31219806;34203471;34428180", "class_list": "", "function": "Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0B3", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:1990423 RZZ complex;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1903394 protein localization to kinetochore involved in kinetochore assembly;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C3Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CTN8-1", "uniprot_id": "LHPL3_MOUSE", "mass": 24686.0, "length": 222, "protein_name": "LHFPL tetraspan subfamily member 3 protein", "gene_name": "Lhfpl3", "organism": "Mouse", "refseq_name": "LHFPL tetraspan subfamily member 3 protein isoform 1", "refseq_ac": "NP_084266", "gene_names_uniprotkb": "Lhfpl3", "gene_names_refseq": "A930031L14Rik; Lhfpl3", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 3 protein; Lipoma HMGIC fusion partner-like 3 protein", "protein_names_refseq": "LHFPL tetraspan subfamily member 3 protein isoform 1; LHFPL tetraspan subfamily member 3 protein; lipoma HMGIC fusion partner-like 3 protein", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 67 (Disease Ontology:DOID:0110518)", "pathway": " (mmu:269629)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15905332;21750661;26964900", "class_list": "", "function": "The authors present an overview of the Lhfp gene family in mouse and humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CTN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08288-1", "uniprot_id": "LYAR_MOUSE", "mass": 43736.0, "length": 388, "protein_name": "Cell growth-regulating nucleolar protein", "gene_name": "Lyar", "organism": "Mouse", "refseq_name": "cell growth-regulating nucleolar protein isoform 1", "refseq_ac": "NP_079557", "gene_names_uniprotkb": "Lyar", "gene_names_refseq": "Lyar; MLZ-264", "protein_names_uniprotkb": "Cell growth-regulating nucleolar protein; Ly1 antibody-reactive protein; MLZ-264; Protein expressed in male leptotene and zygotene spermatocytes 264", "protein_names_refseq": "cell growth-regulating nucleolar protein isoform 1; cell growth-regulating nucleolar protein; ly1 antibody-reactive protein; protein expressed in male leptotene and zygotene spermatocytes 264", "tax_id": 10090, "disease": "", "pathway": " (mmu:17089)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19489080;20339383;21750661;22645316;23212345;24990247;25092918;25735755;30779550;34428180;8491376", "class_list": "", "function": "Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755). Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Results show that LYAR protein expression is testis-predominant but can also be found in cancer cells originated from tissues other than testis. Lyar seems to promote proliferation of NIH-3T3 cells., [RefSeq, PubMed]; These results suggest that Lyar is a genuine RPE phagocytosis ligand, which in turn supports the validity of OPD/PFC as the only available approach for unbiased identification of phagocytosis ligands with broad applicability to various phagocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9X2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0140416 transcription regulator inhibitor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0050766 positive regulation of phagocytosis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q08288-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJC7-1", "uniprot_id": "KLRE1_MOUSE", "mass": 26265.0, "length": 226, "protein_name": "Killer cell lectin-like receptor subfamily E member 1", "gene_name": "Klre1", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily E member 1 isoform 1", "refseq_ac": "NP_705818", "gene_names_uniprotkb": "Klre1; NKG2I", "gene_names_refseq": "Klre-1; Klre1; NKG2I", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily E member 1", "protein_names_refseq": "killer cell lectin-like receptor subfamily E member 1 isoform 1; killer cell lectin-like receptor subfamily E member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243655)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12715246;12782717;14707119;15069013;18713988;21750661", "class_list": "glycogene", "function": "Cloning and functional characterization of a novel natural killer (NK) cell receptor termed KLRE1, [RefSeq, PubMed]; Lectin-like receptor for natural killer (NK) cells (PubMed:14707119, PubMed:15069013, PubMed:18713988). Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:14707119, PubMed:15069013, PubMed:18713988). Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988). Plays a role in allogeneic recognition by the immune system (PubMed:14707119, PubMed:15069013)., [UniProtKB, PubMed, PubMed, PubMed]; Mediates recognition and rejection of allogeneic target cells in the host immune system, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80WP0", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0032729 positive regulation of type II interferon production;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0030101 natural killer cell activation;GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CJC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35652-1", "uniprot_id": "LHX8_MOUSE", "mass": 40710.0, "length": 367, "protein_name": "LIM/homeobox protein Lhx8", "gene_name": "Lhx8", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx8 isoform 1", "refseq_ac": "NP_034843", "gene_names_uniprotkb": "Lhx8; Lhx7", "gene_names_refseq": "L3; Lhx7; Lhx8", "protein_names_uniprotkb": "LIM/homeobox protein Lhx8; L3; LIM homeobox protein 7; LIM homeobox protein 8; LIM/homeobox protein Lhx7", "protein_names_refseq": "LIM homeo box protein 8; LIM homeobox protein 7; LIM/homeobox protein Lhx7; LIM/homeobox protein Lhx8 isoform 1; LIM/homeobox protein Lhx8", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:16875)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;8929991;9570771;9598319", "class_list": "", "function": "Transcription factor involved in differentiation of certain neurons and mesenchymal cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70163;O88707;Q3TMT2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001674 female germ cell nucleus", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007611 learning or memory;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35652-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97873-1", "uniprot_id": "LOXL1_MOUSE", "mass": 66506.0, "length": 607, "protein_name": "Lysyl oxidase homolog 1", "gene_name": "Loxl1", "organism": "Mouse", "refseq_name": "lysyl oxidase homolog 1 preproprotein", "refseq_ac": "NP_034859", "gene_names_uniprotkb": "Loxl1; Lox2; Loxl", "gene_names_refseq": "Loxl1; Loxl", "protein_names_uniprotkb": "Lysyl oxidase homolog 1; 1.4.3.13; Lysyl oxidase 2; Lysyl oxidase-like protein 1", "protein_names_refseq": "lysyl oxidase 2; lysyl oxidase homolog 1 preproprotein; lysyl oxidase homolog 1; lysyl oxidase-like protein 1", "tax_id": 10090, "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); exfoliation syndrome (Disease Ontology:DOID:13641)", "pathway": " (mmu:16949); (R-MMU-1566948); (R-MMU-2243919)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "14745449;21750661;34428180;34569648;37828378;37905384;38466882;9119402;9250877", "class_list": "", "function": "Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers (PubMed:14745449). Essential for the elastic fiber homeostasis and for their maintenance at adult age (PubMed:14745449)., [UniProtKB, PubMed]; Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic background determines severity of Loxl1-mediated systemic and ocular elastosis in mice., [RefSeq, PubMed]; Selective depletion of hepatic stellate cells-specific LOXL1 alleviates liver fibrosis., [RefSeq, PubMed]; This gene encodes a member of the lysyl oxidase family of copper-dependent enzymes that catalyze the formation of lysine-derived crosslinks in proteins such as collagen and elastin. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional enzyme. Mice lacking the encoded protein fail to deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZY4;Q99KX3", "ec_number_list": "1.4.3.13;3.4.24.19;3.4.24.-;1.4.3.-", "go_molecular_function": "GO:0005507 copper ion binding;GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001669 acrosomal vesicle;GO:0005604 basement membrane;GO:0001527 microfibril", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0032496 response to lipopolysaccharide;GO:0035904 aorta development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97873-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01639-1", "uniprot_id": "KV5A7_MOUSE", "mass": 14311.0, "length": 130, "protein_name": "Immunoglobulin kappa chain variable 9-120", "gene_name": "Igkv9-120", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Igkv9-120; Gm5571", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa chain variable 9-120; Ig kappa chain V-V region MOPC 41", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "111146;21750661;34428180;403522;4162931", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01640", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01639-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01633-1", "uniprot_id": "KV5A1_MOUSE", "mass": 16434.0, "length": 149, "protein_name": "Immunoglobulin kappa chain variable 6-17", "gene_name": "Igkv6-17", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Igkv6-17; Igk-V19-17", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa chain variable 6-17; Ig kappa chain V-V region MPC11; Ig kappa chain V19-17", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "21750661;34428180;35984892;418775;6245773;6288267", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZP3-1", "uniprot_id": "KLHL2_MOUSE", "mass": 65983.0, "length": 593, "protein_name": "Kelch-like protein 2", "gene_name": "Klhl2", "organism": "Mouse", "refseq_name": "kelch-like protein 2", "refseq_ac": "NP_848748", "gene_names_uniprotkb": "Klhl2", "gene_names_refseq": "6030411N21Rik; 8530402H02Rik; ABP-KELCH; Klhl2; Mav", "protein_names_uniprotkb": "Kelch-like protein 2", "protein_names_refseq": "kelch-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77113); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21549840;21750661;25556166;26607111;28414128", "class_list": "", "function": "Accordingly, medullary WNK4 protein levels were significantly increased in the kidneys of KLHL2(-/-) mice. KLHL2 is indeed a physiological regulator of WNK4 in vivo; however, its function might be different from that of KLHL3 because KLHL2 mainly localized in medulla., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:21549840). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (PubMed:21549840). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Plays a role in the reorganization of the actin cytoskeleton (By similarity). Promotes growth of cell projections in oligodendrocyte precursors (By similarity)., [UniProtKB, PubMed, UniProtKB]; These results suggest that KLHL2 likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4., [RefSeq, PubMed]; This study showed that KLHL2 is involved in the physiologic regulation of the WNK signal cascade., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCU0;Q8R3U4", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0001725 stress fiber", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8JZP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXD8-1", "uniprot_id": "LIMD1_MOUSE", "mass": 71422.0, "length": 668, "protein_name": "LIM domain-containing protein 1", "gene_name": "Limd1", "organism": "Mouse", "refseq_name": "LIM domain-containing protein 1 isoform 1", "refseq_ac": "NP_038888", "gene_names_uniprotkb": "Limd1", "gene_names_refseq": "D9Ertd192e; Limd1", "protein_names_uniprotkb": "LIM domain-containing protein 1", "protein_names_refseq": "LIM domain-containing protein 1 isoform 1; LIM domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:29806); (R-MMU-1234176)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10647888;17092936;18331720;18657804;21183079;21750661;25153642;26495903;28528544;30016717;30059200;31219806;32782141;33891898;36084651;40885482", "class_list": "", "function": "Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation., [UniProtKB, PubMed, PubMed]; LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8G4;Q9CW55", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016477 cell migration;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9QXD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XD2-1", "uniprot_id": "LIMS2_MOUSE", "mass": 39031.0, "length": 341, "protein_name": "LIM and senescent cell antigen-like-containing domain protein 2", "gene_name": "Lims2", "organism": "Mouse", "refseq_name": "LIM and senescent cell antigen-like-containing domain protein 2 isoform 1", "refseq_ac": "NP_659111", "gene_names_uniprotkb": "Lims2; Pinch2", "gene_names_refseq": "Lims2; PINCH2", "protein_names_uniprotkb": "LIM and senescent cell antigen-like-containing domain protein 2; PINCH-2; Particularly interesting new Cys-His protein 2", "protein_names_refseq": "LIM and senescent cell antigen-like-containing domain protein 2 isoform 1; LIM and senescent cell antigen-like-containing domain protein 2; particularly interesting new Cys-His protein 2", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2W (Disease Ontology:DOID:0110288)", "pathway": " (mmu:225341); (R-MMU-446343); (R-MMU-446353)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12651156;16317048;16737959;19652092;21750661;34428180;36385586", "class_list": "", "function": "Absence of either PINCH1 or PINCH2 in myocardium leads to exacerbated cardiac injury and deterioration in cardiac function after myocardial infarction., [RefSeq, PubMed]; Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors., [UniProtKB]; LIM1 domain only of either PINCH1 or PINCH2 can prevent ILK degradation despite their failure to localize to focal adhesions. Erratum:[J Cell Sci. 2006 Jan 1;119(Pt 1):196], [RefSeq, PubMed]; Requirement for PINCH in skeletal myoblast differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0050680 negative regulation of epithelial cell proliferation;GO:0098609 cell-cell adhesion;GO:0061351 neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91XD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JQ7-1", "uniprot_id": "KNL1_MOUSE", "mass": 238185.0, "length": 2119, "protein_name": "Outer kinetochore KNL1 complex subunit KNL1", "gene_name": "Knl1", "organism": "Mouse", "refseq_name": "outer kinetochore KNL1 complex subunit KNL1 isoform 1", "refseq_ac": "NP_083893", "gene_names_uniprotkb": "Knl1; Casc5", "gene_names_refseq": "2310043D08Rik; 5730505K17Rik; Casc5; Knl1", "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit KNL1; Cancer susceptibility candidate gene 5 protein homolog; Kinetochore scaffold 1; Kinetochore-null protein 1; Protein CASC5", "protein_names_refseq": "cancer susceptibility candidate 5; kinetochore-null protein 1; outer kinetochore KNL1 complex subunit KNL1 isoform 1; outer kinetochore KNL1 complex subunit KNL1; protein CASC5", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 4 (Disease Ontology:DOID:0070291); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); primary microcephaly (Disease Ontology:DOID:0070297); sarcoma (Disease Ontology:DOID:1115)", "pathway": " (mmu:76464)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;25428506;31197172;32782141;35167144;36852467;36904774", "class_list": "", "function": "Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1. Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (By similarity). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (PubMed:35167144, PubMed:36904774). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (PubMed:35167144, PubMed:36904774)., [UniProtKB, UniProtKB, PubMed, PubMed]; Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation., [RefSeq, PubMed]; Study in mouse model finds that following Knl1 deletion, segregation errors in mitotic neural progenitor cells give rise to DNA damage on the missegregated chromosomes. This triggers rapid p53 activation and robust apoptotic and microglial phagocytic responses that extensively eliminate cells with somatic genome damage, thus causing microcephaly. Publication Status: Online-Only, [RefSeq, PubMed]; The Loss-Function of KNL1 Causes Oligospermia and Asthenospermia in Mice by Affecting the Assembly and Separation of the Spindle through Flow Cytometry and Immunofluorescence. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A3KGI3;A3KGI4;Q8CCH6;Q9CV38", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q66JQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AQ75-1", "uniprot_id": "KRT36_MOUSE", "mass": 52790.0, "length": 473, "protein_name": "Keratin, type I cuticular Ha6", "gene_name": "Krt36", "organism": "Mouse", "refseq_name": "keratin, type I cuticular Ha6", "refseq_ac": "NP_001167570", "gene_names_uniprotkb": "Krt36; Hra-1; Krt1-22; Krt1-5", "gene_names_refseq": "HRa-1; K36; Krt1-22; Krt1-5; Krt36; MHRa-1", "protein_names_uniprotkb": "Keratin, type I cuticular Ha6; K36; Keratin-36; Keratin-5; MHRa-1; Type I keratin 48 kDa", "protein_names_refseq": "keratin complex 1, acidic, gene 5; keratin, type I cuticular Ha6; keratin-5; type I keratin 48 kDa (MHRa-1)", "tax_id": 10090, "disease": "", "pathway": " (mmu:16673); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1385239;34428180;37738023", "class_list": "", "function": "E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61861", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0045616 regulation of keratinocyte differentiation;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1AQ75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1B1A0-1", "uniprot_id": "LMBL4_MOUSE", "mass": 70898.0, "length": 621, "protein_name": "Lethal(3)malignant brain tumor-like protein 4", "gene_name": "L3mbtl4", "organism": "Mouse", "refseq_name": "lethal(3)malignant brain tumor-like protein 4 isoform 1", "refseq_ac": "NP_796252", "gene_names_uniprotkb": "L3mbtl4", "gene_names_refseq": "A730037L19Rik; D930040M24Rik; L3mbtl4", "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 4; L(3)mbt-like protein 4", "protein_names_refseq": "l(3)mbt-like protein 4; lethal(3)malignant brain tumor-like protein 4 isoform 1; lethal(3)malignant brain tumor-like protein 4", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:320858)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RVB2;Q8BHZ8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1B1A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RUR4-1", "uniprot_id": "KPRP_MOUSE", "mass": 71740.0, "length": 657, "protein_name": "Keratinocyte proline-rich protein", "gene_name": "Kprp", "organism": "Mouse", "refseq_name": "keratinocyte proline-rich protein", "refseq_ac": "NP_082905", "gene_names_uniprotkb": "Kprp", "gene_names_refseq": "1110001M24Rik; Kprp", "protein_names_uniprotkb": "Keratinocyte proline-rich protein", "protein_names_refseq": "keratinocyte proline-rich protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:433619)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30905808", "class_list": "", "function": "Heterozygous knockout (Kprp+/-) mice exhibited reduced KPRP expression to level like that of human atopic dermatitis (AD) lesional skin. Kprp+/- mice showed abnormal desmosome structure and detachment of lower layers of the stratum corneum. Percutaneous inflammation by topical application of croton oil or oxazolone was enhanced, and epicutaneous immunization with ovalbumin induced a high level of IgE in Kprp+/- mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1P8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0061436 establishment of skin barrier;GO:0008544 epidermis development;GO:0043588 skin development;GO:0002934 desmosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RUR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35125-1", "uniprot_id": "LRC23_MOUSE", "mass": 39292.0, "length": 340, "protein_name": "Leucine-rich repeat-containing protein 23", "gene_name": "Lrrc23", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 23", "refseq_ac": "NP_001289484", "gene_names_uniprotkb": "Lrrc23; Lrpb7", "gene_names_refseq": "4921537K05Rik; B7; Lrpb7; Lrrc23", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 23; Leucine-rich protein B7", "protein_names_refseq": "leucine-rich protein B7; leucine-rich repeat-containing protein 23", "tax_id": 10090, "disease": "spermatogenic failure 92 (Disease Ontology:DOID:0070591)", "pathway": " (mmu:16977)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17971504;21750661;21952136;34428180;34585727;38091523;9445485", "class_list": "", "function": "Essential for sperm motility and male fertility. Plays an important role in the proper assembly of the third radial spoke (RS3) head and the bridge structure between RS2 and RS3 in the sperm flagella., [UniProtKB, PubMed, PubMed]; LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice., [RefSeq, PubMed]; LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility. Publication Status: Online-Only, [RefSeq, PubMed]; Lrrc23 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0062177 radial spoke assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R502-1", "uniprot_id": "LRC8C_MOUSE", "mass": 92372.0, "length": 803, "protein_name": "Volume-regulated anion channel subunit LRRC8C", "gene_name": "Lrrc8c", "organism": "Mouse", "refseq_name": "volume-regulated anion channel subunit LRRC8C", "refseq_ac": "NP_598658", "gene_names_uniprotkb": "Lrrc8c; Ad158; Fad158", "gene_names_refseq": "AD158; E430036I04Rik; Lrrc8c; fad158", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8C; Factor for adipocyte differentiation 158; Leucine-rich repeat-containing protein 8C", "protein_names_refseq": "factor for adipocyte differentiation 158; leucine-rich repeat-containing protein 8C; volume-regulated anion channel subunit LRRC8C", "tax_id": 10090, "disease": "", "pathway": " (mmu:100604); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;15184384;15564382;18250455;20173027;20484733;21750661;21804215;24782309;25428506;25605945;27802388;29187734;29769723;30084848;30779550;31219806;34428180;36522427;36928458;37828378;39627609;39950214", "class_list": "", "function": "Fad158 has a role in regulating adipocyte differentiation, [RefSeq, PubMed]; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723, PubMed:36522427, PubMed:36928458). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:36522427, PubMed:36928458). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Structure of a volume-regulated heteromeric LRRC8A/C channel., [RefSeq, PubMed]; These results indicate that fad158 is a key factor in the development of obesity and insulin resistance caused by a high-fat diet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEP9;Q8C296;Q8R0N7;Q8R3G5", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0045444 fat cell differentiation;GO:0015734 taurine transmembrane transport;GO:0071470 cellular response to osmotic stress;GO:0034214 protein hexamerization", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q8R502-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0F3-1", "uniprot_id": "LMAN1_MOUSE", "mass": 57789.0, "length": 517, "protein_name": "Protein ERGIC-53", "gene_name": "Lman1", "organism": "Mouse", "refseq_name": "protein ERGIC-53 precursor", "refseq_ac": "NP_001165533", "gene_names_uniprotkb": "Lman1; Ergic53", "gene_names_refseq": "2610020P13Rik; C730041J05; ERGIC53; F5F8D; Lman1; MCFD1; MR60; P58; gp58", "protein_names_uniprotkb": "Protein ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; Lectin mannose-binding 1; p58", "protein_names_refseq": "ER-Golgi intermediate compartment 53 kDa protein; protein ERGIC-53 precursor; protein ERGIC-53", "tax_id": 10090, "disease": "factor XIII deficiency (Disease Ontology:DOID:2211); factor V deficiency (Disease Ontology:DOID:2216)", "pathway": " (mmu:70361); (R-MMU-204005); (R-MMU-5694530); (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "21606357;21750661;30791981;33196840;34428180;35820727;37453647", "class_list": "glycogene", "function": "Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression., [RefSeq, PubMed]; LMAN1 promotes the surface trafficking of endogenous gamma-aminobutyric acid type A receptors., [RefSeq, PubMed]; Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005537 D-mannose binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D0F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA39-1", "uniprot_id": "LFG4_MOUSE", "mass": 26647.0, "length": 238, "protein_name": "Protein lifeguard 4", "gene_name": "Tmbim4", "organism": "Mouse", "refseq_name": "protein lifeguard 4", "refseq_ac": "NP_080893", "gene_names_uniprotkb": "Tmbim4; Lfg4", "gene_names_refseq": "0610007H07Rik; Tmbim4", "protein_names_uniprotkb": "Protein lifeguard 4; Transmembrane BAX inhibitor motif-containing protein 4; Z-protein", "protein_names_refseq": "Z-protein; protein lifeguard 4; transmembrane BAX inhibitor motif-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:68212)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19784873;21750661;25428506;30084848;31219806;34203471;35820727;38579014", "class_list": "", "function": "Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release (By similarity)., [UniProtKB]; Regulation of BCR-mediated Ca[2+] mobilization by MIZ1-TMBIM4 safeguards IgG1[+] GC B cell-positive selection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005795 Golgi stack", "go_biological_process": "GO:0007626 locomotory behavior;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DA39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924C6-1", "uniprot_id": "LOXL4_MOUSE", "mass": 84779.0, "length": 757, "protein_name": "Lysyl oxidase homolog 4", "gene_name": "Loxl4", "organism": "Mouse", "refseq_name": "lysyl oxidase homolog 4 isoform 2 precursor", "refseq_ac": "NP_444313", "gene_names_uniprotkb": "Loxl4; Loxc", "gene_names_refseq": "4833426I20Rik; Loxc; Loxl4", "protein_names_uniprotkb": "Lysyl oxidase homolog 4; 1.4.3.13; Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C", "protein_names_refseq": "lysyl oxidase homolog 4 isoform 2 precursor; lysyl oxidase homolog 4; lysyl oxidase-like protein 4; lysyl oxidase-related protein C", "tax_id": 10090, "disease": "", "pathway": " (mmu:67573); (R-MMU-1566948); (R-MMU-2243919)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11292829;21750661;28060764;33807332", "class_list": "", "function": "Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrate that weak LOXL4 expression leads to remodeling of the extracellular matrix through induction of collagen synthesis, deposition, and structural changes., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PXI3", "ec_number_list": "1.4.3.13;3.4.24.19;3.4.24.-;1.4.3.-", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0043235 receptor complex", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q924C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JW4-1", "uniprot_id": "LIMS1_MOUSE", "mass": 37240.0, "length": 325, "protein_name": "LIM and senescent cell antigen-like-containing domain protein 1", "gene_name": "Lims1", "organism": "Mouse", "refseq_name": "LIM and senescent cell antigen-like-containing domain protein 1 isoform 1", "refseq_ac": "NP_080424", "gene_names_uniprotkb": "Lims1; Pinch1", "gene_names_refseq": "2310016J22Rik; 4921524A02Rik; C430041B13Rik; Lims1l; Lims1; PINCH1; PINCH", "protein_names_uniprotkb": "LIM and senescent cell antigen-like-containing domain protein 1; PINCH-1; Particularly interesting new Cys-His protein 1", "protein_names_refseq": "LIM and senescent cell antigen-like-containing domain protein 1 isoform 1; LIM and senescent cell antigen-like-containing domain protein 1; particularly interesting new Cys-His protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:110829); (R-MMU-446343); (R-MMU-446353); (R-MMU-446388)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16737959;21750661;34428180;36385586;38062244", "class_list": "", "function": "Requirement for PINCH in skeletal myoblast differentiation., [RefSeq, PubMed]; The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway., [RefSeq, PubMed]; Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAT7;Q8BTR6;Q9D5T4", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99JW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQR5-1", "uniprot_id": "LIME1_MOUSE", "mass": 29551.0, "length": 269, "protein_name": "Lck-interacting transmembrane adapter 1", "gene_name": "Lime1", "organism": "Mouse", "refseq_name": "lck-interacting transmembrane adapter 1", "refseq_ac": "NP_076173", "gene_names_uniprotkb": "Lime1; Lime", "gene_names_refseq": "2810038K19Rik; LIME; Lime1", "protein_names_uniprotkb": "Lck-interacting transmembrane adapter 1; Lck-interacting molecule", "protein_names_refseq": "lck-interacting molecule; lck-interacting transmembrane adapter 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72699)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14610044;16249387;21750661", "class_list": "", "function": "Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules., [UniProtKB, PubMed, PubMed]; LIME is an essential transmembrane adaptor linking B-cell receptor ligation to the downstream signaling events that lead to B-cell activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0019815 B cell receptor complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006357 regulation of transcription by RNA polymerase II;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q149R9-1", "uniprot_id": "LPAR5_MOUSE", "mass": 41394.0, "length": 372, "protein_name": "Lysophosphatidic acid receptor 5", "gene_name": "Lpar5", "organism": "Mouse", "refseq_name": "lysophosphatidic acid receptor 5", "refseq_ac": "NP_001156740", "gene_names_uniprotkb": "Lpar5; Gm1072; Gpr92", "gene_names_refseq": "GPR93; Gm1072; Gpr92; LPA5; Lpar5", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 5; G protein-coupled receptor 92; LPA receptor 5; LPA-5", "protein_names_refseq": "G protein-coupled receptor 92; LPA receptor 5; LPA-5; lysophosphatidic acid receptor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:381810); (R-MMU-416476); (R-MMU-418594); (R-MMU-419408)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12679517;16651401;21750661;37837357;38593468", "class_list": "", "function": "Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling., [RefSeq, PubMed]; GPR92 is highly expressed in the lymphocyte compartment of the gastrointestinal tract, [RefSeq, PubMed]; LPA5-Dependent signaling regulates regeneration of the intestinal epithelium following irradiation., [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2G2;Q80T30", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0048266 behavioral response to pain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q149R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZU5-1", "uniprot_id": "KR151_MOUSE", "mass": 16242.0, "length": 150, "protein_name": "Keratin-associated protein 15-1", "gene_name": "Krtap15-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 15-1", "refseq_ac": "NP_038741", "gene_names_uniprotkb": "Krtap15-1; Krtap15; Pmg2", "gene_names_refseq": "Krtap15-1; Krtap15; Pmg-2; Pmg2", "protein_names_uniprotkb": "Keratin-associated protein 15-1; Keratin-associated protein 15; Pubertal mammary gland-specific protein 2", "protein_names_refseq": "keratin associated protein 15; keratin-associated protein 15-1; pubertal mammary gland-specific protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26560)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10446281;15385554;21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60652-1", "uniprot_id": "KLRA5_MOUSE", "mass": 30843.0, "length": 266, "protein_name": "Killer cell lectin-like receptor 5", "gene_name": "Klra5", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor 5", "refseq_ac": "NP_032489", "gene_names_uniprotkb": "Klra5; Ly-49e; Ly49-e; Ly49e", "gene_names_refseq": "Klra5; Ly49e", "protein_names_uniprotkb": "Killer cell lectin-like receptor 5; Ly-49e; Lymphocyte antigen 49e; T-cell surface glycoprotein Ly-49E", "protein_names_refseq": "Ly49E receptor; T-cell surface glycoprotein Ly-49E; class I MHC receptor KLRA5; killer cell lectin-like receptor 5; ly-49e; lymphocyte antigen 49e", "tax_id": 10090, "disease": "", "pathway": " (mmu:16636)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11254682;21750661;25310588;27469529;27585789;34428180;36210013;8027540", "class_list": "", "function": "Ly49E is expressed on a high proportion of CD8alphaalpha-positive intestinal intraepithelial lymphocytes. Erratum:[PLoS One. 2015 Apr 09;10(4):e0124464. doi: 10.1371/journal.pone.0124464. PMID: 25856310] Publication Status: Online-Only, [RefSeq, PubMed]; Ly49E is highly expressed on epidermal gammadelta T cells and liver NK cells, this receptor does not play a major role in the control of skin tumour formation or in lung and liver tumour development. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor on natural killer (NK) cells for class I MHC., [UniProtKB]; This study shows that Ly49E expression on intraepithelial lymphocytes does not influence the development or progression of intestinal cancer, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q60652-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7Q0-1", "uniprot_id": "LYG1_MOUSE", "mass": 21870.0, "length": 197, "protein_name": "Lysozyme g-like protein 1", "gene_name": "Lyg1", "organism": "Mouse", "refseq_name": "lysozyme g-like protein 1 precursor", "refseq_ac": "NP_081387", "gene_names_uniprotkb": "Lyg1", "gene_names_refseq": "2300002O18Rik; Lyg1", "protein_names_uniprotkb": "Lysozyme g-like protein 1; 3.2.1.-", "protein_names_refseq": "lysozyme g-like protein 1 precursor; lysozyme g-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69541)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34262560", "class_list": "glycogene;glycosylhydrolase", "function": "LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells. Erratum:[Front Immunol. 2021 Sep 16;12:762728. doi: 10.3389/fimmu.2021.762728. PMID: 34603343] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0009253 peptidoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D7Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1L9-1", "uniprot_id": "LTOR5_MOUSE", "mass": 9642.0, "length": 91, "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "Lamtor5", "organism": "Mouse", "refseq_name": "ragulator complex protein LAMTOR5", "refseq_ac": "NP_081050", "gene_names_uniprotkb": "Lamtor5; Hbxip; Xip", "gene_names_refseq": "1110003H18Rik; Hbxip; Lamtor5; XIP", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR5; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5", "protein_names_refseq": "HBV X-interacting protein homolog; HBX-interacting protein homolog; hepatitis B virus X-interacting protein homolog; hepatitis B virus x interacting protein; late endosomal/lysosomal adaptor and MAPK and MTOR activator 5; ragulator complex protein LAMTOR5", "tax_id": 10090, "disease": "", "pathway": " (mmu:68576); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "21750661;29259128;31337951;31467416;35608036;38639386", "class_list": "", "function": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Defective Lamtor5 Leads to Autoimmunity by Deregulating v-ATPase and Lysosomal Acidification., [RefSeq, PubMed]; Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1., [RefSeq, PubMed]; Hbxip stimulated insulin enhancer activity by interacting with Pdx-1 and recruiting Neurod1 to Pdx-1., [RefSeq, PubMed]; Study found LAMTOR5 was overexpressed in human and Pten cKO mice head and neck squamous cell carcinoma (HNSCC), and its expression was significantly associated with patients' overall survival, lymph node metastasis and lymph node grade. Furthermore, LAMTOR5 expression was significantly correlated with the expression of immune checkpoints and macrophage markers. Publication Status: Online-Only, [RefSeq, PubMed]; The metabolic regulator Lamtor5 suppresses inflammatory signaling via regulating mTOR-mediated TLR4 degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJV9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0032008 positive regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D1L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCX6-1", "uniprot_id": "KPTN_MOUSE", "mass": 47545.0, "length": 430, "protein_name": "KICSTOR complex protein kaptin", "gene_name": "Kptn", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kptn", "gene_names_refseq": "", "protein_names_uniprotkb": "KICSTOR complex protein kaptin", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 41 (Disease Ontology:DOID:0081206)", "pathway": " (mmu:70394); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;37507081", "class_list": "", "function": "As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0140007 KICSTOR complex;GO:0098871 postsynaptic actin cytoskeleton;GO:0030027 lamellipodium;GO:0005765 lysosomal membrane;GO:0032420 stereocilium", "go_biological_process": "GO:0007015 actin filament organization;GO:0042149 cellular response to glucose starvation;GO:0034198 cellular response to amino acid starvation;GO:1904262 negative regulation of TORC1 signaling;GO:0061462 protein localization to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08677-1", "uniprot_id": "KNG1_MOUSE", "mass": 73102.0, "length": 661, "protein_name": "Kininogen-1", "gene_name": "Kng1", "organism": "Mouse", "refseq_name": "kininogen-1 isoform 1 precursor", "refseq_ac": "NP_001095881", "gene_names_uniprotkb": "Kng1; Kng", "gene_names_refseq": "Kng1; Kng", "protein_names_uniprotkb": "Kininogen-1", "protein_names_refseq": "H-kininigen; L-kininogen; kininogen-1 isoform 1 precursor", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); high molecular weight kininogen deficiency (Disease Ontology:DOID:0111676); IgA vasculitis (Disease Ontology:DOID:11123); hereditary angioedema (Disease Ontology:DOID:14735); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (mmu:16644)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12023845;14506238;15134344;16944957;17330941;20116414;21750661;26495903;30899004;32152506;32707450;33706097;33827130;34428180;36288343;37507081;39627609;9199253", "class_list": "", "function": "Domain 5 of kininogen was identified as an anti-adhesive component with a potent anti-inflammatory action in a peritonitis mouse model. Review article, [RefSeq, PubMed]; His-Gly-Lys motif and lysine residue (Lys487) play essential roles in inhibition of cell adhesion and invasion in vitro and in prevention of metastasis of cancer cells in vivo, [RefSeq, PubMed]; Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis., [RefSeq, PubMed]; Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting., [UniProtKB]; Overexpression of Kininogen-1 aggravates oxidative stress and mitochondrial dysfunction in DOX-induced cardiotoxicity., [RefSeq, PubMed]; Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure., [RefSeq, PubMed]; The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O08676;Q32MX7;Q6S9I1;Q91XK5", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006954 inflammatory response;GO:0007162 negative regulation of cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O08677-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35739-1", "uniprot_id": "KLF9_MOUSE", "mass": 27170.0, "length": 244, "protein_name": "Krueppel-like factor 9", "gene_name": "Klf9", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Klf9; Bteb-1; Bteb1; Bteb", "gene_names_refseq": "", "protein_names_uniprotkb": "Krueppel-like factor 9; BTE-binding protein 1; Basic transcription element-binding protein 1; GC-box-binding protein 1; Transcription factor BTEB1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9858544", "class_list": "", "function": "Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54785-1", "uniprot_id": "LIMK2_MOUSE", "mass": 72202.0, "length": 638, "protein_name": "LIM domain kinase 2", "gene_name": "Limk2", "organism": "Mouse", "refseq_name": "LIM domain kinase 2 isoform c", "refseq_ac": "NP_001029202", "gene_names_uniprotkb": "Limk2", "gene_names_refseq": "Limk-2; Limk2; whe", "protein_names_uniprotkb": "LIM domain kinase 2; 2.7.11.1; LIMK-2", "protein_names_refseq": "LIM domain kinase 2 isoform c; LIM kinase 2; LIM motif-containing protein kinase 2", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:16886)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18332102;21750661;25605945;34407403;34428180;36922679;39153710;40021952;9425257;9441759;9610354;9705845", "class_list": "", "function": "LIM kinase 2 activates cardiac fibroblasts and exacerbates postinfarction left ventricular remodeling via crosstalk between the canonical and non-canonical Wnt pathways., [RefSeq, PubMed]; LIMK2 promotes melanoma tumor growth and metastasis through G3BP1-ESM1 pathway-mediated apoptosis inhibition., [RefSeq, PubMed]; NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54776;O55238;Q9QUL4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0030036 actin cytoskeleton organization;GO:1900182 positive regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O54785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88855-1", "uniprot_id": "LT4R1_MOUSE", "mass": 38252.0, "length": 351, "protein_name": "Leukotriene B4 receptor 1", "gene_name": "Ltb4r", "organism": "Mouse", "refseq_name": "leukotriene B4 receptor 1", "refseq_ac": "NP_032545", "gene_names_uniprotkb": "Ltb4r; Bltr; Ltb4r1", "gene_names_refseq": "BLT1; BLTR; LTB4-R1; Ltb4r1; Ltb4r; mBLTR", "protein_names_uniprotkb": "Leukotriene B4 receptor 1; LTB4-R 1; LTB4-R1", "protein_names_refseq": "LTB4 receptor; leukotriene B4 receptor 1", "tax_id": 10090, "disease": "hereditary folate malabsorption (Disease Ontology:DOID:0111678); carotid artery disease (Disease Ontology:DOID:3407); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16995); (R-MMU-391906); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10085095;27802388;35820727;9743525", "class_list": "", "function": "Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0001632 leukotriene B4 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01629-1", "uniprot_id": "KV2A4_MOUSE", "mass": 12221.0, "length": 112, "protein_name": "Ig kappa chain V-II region 2S1.3", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-II region 2S1.3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7141411", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01629-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01630-1", "uniprot_id": "KV2A6_MOUSE", "mass": 12496.0, "length": 113, "protein_name": "Ig kappa chain V-II region 7S34.1", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-II region 7S34.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6409088", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune 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"reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04941-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04943-1", "uniprot_id": "KV6A9_MOUSE", "mass": 11573.0, "length": 107, "protein_name": "Ig kappa chain V-VI region NQ6-8.3.1", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-VI region NQ6-8.3.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6877353", "class_list": "", "function": "Anti-2-phenyl oxazolone (PHOX) Antibody., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04944-1", "uniprot_id": "KV6AA_MOUSE", "mass": 11613.0, "length": 107, "protein_name": "Ig kappa chain V-VI region NQ5-78.2.6", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-VI region NQ5-78.2.6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6877353", "class_list": "", "function": "Anti-2-phenyl oxazolone (PHOX) Antibody., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04946-1", "uniprot_id": "KV5AM_MOUSE", "mass": 11870.0, "length": 108, "protein_name": "Ig kappa chain V-V region NQ5-89.4", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-V region NQ5-89.4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6877353", "class_list": "", "function": "Anti-2-phenyl oxazolone (PHOX) Antibody., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11369-1", "uniprot_id": "LORF2_MOUSE", "mass": 149581.0, "length": 1281, "protein_name": "LINE-1 retrotransposable element ORF2 protein", "gene_name": "Pol", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pol; Gm17492", "gene_names_refseq": "", "protein_names_uniprotkb": "LINE-1 retrotransposable element ORF2 protein; L1; Long interspersed element-1; ORF2p; Retrovirus-related Pol polyprotein LINE-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "28662698;3008107;3023821;31219806;7533116", "class_list": "", "function": "Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition (By similarity). Selectively binds and reversely transcribes RNA with a poly(A) tail consisting of at least 20 adenosines (By similarity). Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA (By similarity). Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to the sites of LINE-1 integration in the genome (By similarity). Conformational properties of the target DNA sequence rather than specific nucleotides are key determinants of the ORF2p capacity for sequence-specific DNA recognition (By similarity). Unlike related endonucleases, does not bend the DNA helix but causes compression near the cleavage site (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60713;Q61787", "ec_number_list": "2.7.7.49;3.1.11.-;2.7.7.31;3.1.21.-;2.7.7.7;4.2.99.-;2.7.7.102;5.6.2.-;4.2.99.18", "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004519 endonuclease activity", "go_cellular_component": "", "go_biological_process": "GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11369-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20937-1", "uniprot_id": "KLRA1_MOUSE", "mass": 30498.0, "length": 262, "protein_name": "T-cell surface glycoprotein YE1/48", "gene_name": "Klra1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Klra1; Ly-49a; Ly-49; Ly49A; Ly49", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell surface glycoprotein YE1/48; Ly-49a; Lymphocyte antigen 49a; T lymphocyte antigen A1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10604468;2783949;2787364", "class_list": "glycogene", "function": "Receptor on natural killer (NK) cells for H-2d alleles. Inhibits the activity of NK cells thus preventing cell lysis., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20937-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27656-1", "uniprot_id": "LIPC_MOUSE", "mass": 57389.0, "length": 510, "protein_name": "Hepatic triacylglycerol lipase", "gene_name": "Lipc", "organism": "Mouse", "refseq_name": "hepatic triacylglycerol lipase isoform 1 precursor", "refseq_ac": "NP_001311401", "gene_names_uniprotkb": "Lipc; Hpl", "gene_names_refseq": "HL; Hpl; Lipc", "protein_names_uniprotkb": "Hepatic triacylglycerol lipase; 3.1.1.32; 3.1.1.3; 3.1.1.5; HL; Hepatic lipase; Lipase member C; Lysophospholipase; Phospholipase A1", "protein_names_refseq": "hepatic lipase; hepatic triacylglycerol lipase isoform 1 precursor; hepatic triacylglycerol lipase; lipase member C; lipase, hepatic; lysophospholipase; phospholipase A1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); familial hyperlipidemia (Disease Ontology:DOID:1168); protein-energy malnutrition (Disease Ontology:DOID:11801); nephrotic syndrome (Disease Ontology:DOID:1184); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypothyroidism (Disease Ontology:DOID:1459); hyperinsulinism (Disease Ontology:DOID:2018); hepatitis (Disease Ontology:DOID:2237); ischemia (Disease Ontology:DOID:326); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15450); (R-MMU-8963889); (R-MMU-8964026)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1840530;2025643;21750661;25428506;26423094;27172975;30084848;34197964", "class_list": "", "function": "Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Hepatic lipase KO mice had dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. Also glucose intolerance, pancreatic and hepatic inflammation and steatosis., [RefSeq, PubMed]; Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain., [RefSeq, PubMed]; The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC44", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;3.1.1.4;3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.23;3.1.1.79;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;3.1.1.116;3.1.1.111;3.1.1.118;2.3.1.51;3.1.-.-;3.1.4.-", "go_molecular_function": "GO:0008201 heparin binding;GO:0016298 lipase activity;GO:0034185 apolipoprotein binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle;GO:0005770 late endosome", "go_biological_process": "GO:0046473 phosphatidic acid metabolic process;GO:0097006 regulation of plasma lipoprotein particle levels;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39655-1", "uniprot_id": "LOX12_MOUSE", "mass": 75390.0, "length": 663, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX12", "gene_name": "Alox12", "organism": "Mouse", "refseq_name": "polyunsaturated fatty acid lipoxygenase ALOX12 isoform 2", "refseq_ac": "NP_001318047", "gene_names_uniprotkb": "Alox12; Alox12p", "gene_names_refseq": "9930022G08Rik; Alox12p; Alox12; P-12LO", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX12; 1.13.11.-; 1.13.11.31; 1.13.11.33; 12S-LOX; 12S-lipoxygenase; Arachidonate (12S)-lipoxygenase; Arachidonate (15S)-lipoxygenase; Linoleate (13S)-lipoxygenase; Lipoxin synthase 12-LO; P-12LO; Platelet-type lipoxygenase 12", "protein_names_refseq": "12S-LOX; 12S-lipoxygenase; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; platelet-type lipoxygenase 12; polyunsaturated fatty acid lipoxygenase ALOX12 isoform 2; polyunsaturated fatty acid lipoxygenase ALOX12", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11684); (R-MMU-2142696); (R-MMU-2142700); (R-MMU-2142712); (R-MMU-9018677); (R-MMU-9025106); (R-MMU-9026290)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10383730;11256953;25293588;34428180;35129022;36599368;7576099;7792391;7868854;8188678;9501222", "class_list": "", "function": "Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:11256953, PubMed:25293588, PubMed:8188678). Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE (PubMed:11256953, PubMed:8188678). Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:9501222). It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA. Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (By similarity). An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)-hydroperoxyoctadecadienoate/ (13S-HPODE) (PubMed:11256953). Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic. Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy. Review article, [RefSeq, PubMed]; Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHG4", "ec_number_list": "1.13.11.-;1.13.11.31;1.13.11.33;1.13.11.12;1.13.11.34", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0047977 hepoxilin-epoxide hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0034440 lipid oxidation;GO:2001301 lipoxin biosynthetic process;GO:0006629 lipid metabolic process;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P39655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43137-1", "uniprot_id": "LIT1_MOUSE", "mass": 18519.0, "length": 165, "protein_name": "Lithostathine-1", "gene_name": "Reg1", "organism": "Mouse", "refseq_name": "lithostathine-1 precursor", "refseq_ac": "NP_033068", "gene_names_uniprotkb": "Reg1", "gene_names_refseq": "PSP; PTP; Reg1", "protein_names_uniprotkb": "Lithostathine-1; Islet of Langerhans regenerating protein 1; PSP; PTP; Pancreatic stone protein 1; Pancreatic thread protein 1; REG 1; Regenerating protein 1", "protein_names_refseq": "REG 1; islet of Langerhans regenerating protein 1; lithostathine-1 precursor; lithostathine-1; pancreatic stone protein 1; pancreatic thread protein 1; regenerating protein 1", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Alzheimer's disease (Disease Ontology:DOID:10652); Sjogren's syndrome (Disease Ontology:DOID:12894); colon cancer (Disease Ontology:DOID:219); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:19692)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "30914711;31166710;36470473;8340418", "class_list": "glycogene", "function": "Keratinocyte Regnase-1, a Downregulator of Skin Inflammation, Contributes to Protection against Tumor Promotion by Limiting Cyclooxygenase-2 Expression., [RefSeq, PubMed]; MiR-7 directly targets reg1 expression in murine pancreatic cells., [RefSeq, PubMed]; Might act as an inhibitor of spontaneous calcium carbonate precipitation., [UniProtKB]; Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0030426 growth cone;GO:0031012 extracellular matrix;GO:0045178 basal part of cell", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:1904699 positive regulation of acinar cell proliferation;GO:1990798 pancreas regeneration;GO:1990864 response to growth hormone-releasing hormone;GO:1990878 cellular response to gastrin", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P43137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51885-1", "uniprot_id": "LUM_MOUSE", "mass": 38265.0, "length": 338, "protein_name": "Lumican", "gene_name": "Lum", "organism": "Mouse", "refseq_name": "lumican precursor", "refseq_ac": "NP_032550", "gene_names_uniprotkb": "Lum; Lcn; Ldc", "gene_names_refseq": "Ldc; Lum; SLRR2D", "protein_names_uniprotkb": "Lumican; KSPG lumican; Keratan sulfate proteoglycan lumican", "protein_names_refseq": "KSPG lumican; keratan sulfate proteoglycan lumican; lumican precursor", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830); Ehlers-Danlos syndrome classic type 1 (Disease Ontology:DOID:14720); pancreatic cancer (Disease Ontology:DOID:1793); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); ureteral obstruction (Disease Ontology:DOID:5199); varicose veins (Disease Ontology:DOID:799)", "pathway": " (mmu:17022); (R-MMU-2022854); (R-MMU-2022857); (R-MMU-216083)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "16944957;17330941;17558413;34428180;36288343;37972853;38081351;7558724", "class_list": "glycogene", "function": "Downregulation of B4GALT5 attenuates cardiac fibrosis through Lumican and Akt/GSK-3beta/beta-catenin pathway., [RefSeq, PubMed]; Impaired healing in an incision wound in corneal stroma in a lumican-null mouse., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP25;Q99JZ3;Q9CXK0", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005583 fibrillar collagen trimer;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:1904010 response to Aroclor 1254;GO:0032914 positive regulation of transforming growth factor beta1 production;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070848 response to growth factor;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P51885-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56563-1", "uniprot_id": "LMIP_MOUSE", "mass": 19621.0, "length": 173, "protein_name": "Lens fiber membrane intrinsic protein", "gene_name": "Lim2", "organism": "Mouse", "refseq_name": "lens fiber membrane intrinsic protein", "refseq_ac": "NP_808361", "gene_names_uniprotkb": "Lim2", "gene_names_refseq": "4833403J20; Lim2; MP17; MP18; MP19; MP20; To3", "protein_names_uniprotkb": "Lens fiber membrane intrinsic protein; MP17; MP18; MP19; MP20", "protein_names_refseq": "lens fiber membrane intrinsic protein; total opacity 3", "tax_id": 10090, "disease": "cataract 19 multiple types (Disease Ontology:DOID:0110263); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:233187)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11290961;21617753;9238094", "class_list": "", "function": "A novel missense mutation in the Lim2 gene affects lens development in a semidominant manner. Since homozygous mutants develop congenital lens opacities, this mouse line can be used as a model for inherited cataract formation in humans., [RefSeq, PubMed]; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 2, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEF3;Q3TNV8;Q99PA6", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0031982 vesicle", "go_biological_process": "GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56563-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57785-1", "uniprot_id": "LFTY2_MOUSE", "mass": 41175.0, "length": 368, "protein_name": "Left-right determination factor 2", "gene_name": "Lefty2", "organism": "Mouse", "refseq_name": "left-right determination factor 2 preproprotein", "refseq_ac": "NP_796073", "gene_names_uniprotkb": "Lefty2; Leftb", "gene_names_refseq": "6030463A22Rik; Ebaf; Lefta; Leftb; Lefty2; lefty-2; lefty-B", "protein_names_uniprotkb": "Left-right determination factor 2; Left-right determination factor B; Protein lefty-2; Protein lefty-B", "protein_names_refseq": "endometrial bleeding associated factor; left-right determination factor 2 preproprotein; left-right determination factor B; left-right determination, factor A", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:320202); (R-MMU-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25428506;9348041", "class_list": "", "function": "Required for left-right asymmetry determination of organ systems in mammals., [UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This protein is also important in self-renewal and differentiation of mouse embryonic stem cells. Mice lacking a functional copy of this gene exhibit defects in axial and left-right patterning. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMF7", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0030509 BMP signaling pathway;GO:0009948 anterior/posterior axis specification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P57785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58022-1", "uniprot_id": "LOXL2_MOUSE", "mass": 87003.0, "length": 776, "protein_name": "Lysyl oxidase homolog 2", "gene_name": "Loxl2", "organism": "Mouse", "refseq_name": "lysyl oxidase homolog 2 precursor", "refseq_ac": "NP_201582", "gene_names_uniprotkb": "Loxl2", "gene_names_refseq": "1110004B06Rik; 4930526G11Rik; 9430067E15Rik; Loxl2", "protein_names_uniprotkb": "Lysyl oxidase homolog 2; 1.4.3.13; Lysyl oxidase-like protein 2", "protein_names_refseq": "lysyl oxidase homolog 2 precursor; lysyl oxidase homolog 2; lysyl oxidase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:94352); (R-MMU-1566948); (R-MMU-2243919)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10842102;15652501;21071451;21835952;24414204;25959397;26495903;31219806;37828378;38824593;39011679", "class_list": "", "function": "LoxL2 is not expressed in MC3T3-E1 cells., [RefSeq, PubMed]; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (By similarity). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (PubMed:25959397). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (By similarity). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (By similarity). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (PubMed:21071451)., [UniProtKB, UniProtKB, PubMed, PubMed]; MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRE6;Q8BS86;Q8C4K0;Q9JJ39", "ec_number_list": "1.4.3.13;3.4.24.19;3.4.24.-;1.4.3.-", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0036211 protein modification process;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P58022-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0L5-1", "uniprot_id": "LRC43_MOUSE", "mass": 74942.0, "length": 667, "protein_name": "Leucine-rich repeat-containing protein 43", "gene_name": "Lrrc43", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 43 isoform 1", "refseq_ac": "NP_001028633", "gene_names_uniprotkb": "Lrrc43; Gm1061", "gene_names_refseq": "Gm1061; Lrrc43", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 43", "protein_names_refseq": "leucine-rich repeat-containing protein 43 isoform 1; leucine-rich repeat-containing protein 43", "tax_id": 10090, "disease": "", "pathway": " (mmu:381741)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIS6;Q3TJS5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V0L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1I0-1", "uniprot_id": "LYG2_MOUSE", "mass": 23762.0, "length": 213, "protein_name": "Lysozyme g-like protein 2", "gene_name": "Lyg2", "organism": "Mouse", "refseq_name": "lysozyme g-like protein 2 precursor", "refseq_ac": "NP_001028599", "gene_names_uniprotkb": "Lyg2; Gm776", "gene_names_refseq": "Gm776; Lyg2", "protein_names_uniprotkb": "Lysozyme g-like protein 2; 3.2.1.-", "protein_names_refseq": "lysozyme g-like protein 2 precursor; lysozyme g-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:332427)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "May act as a potent antibacterial protein that may play a role in the innate immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJU6", "ec_number_list": "", "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0042742 defense response to bacterium;GO:0009253 peptidoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V1I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V2T4-1", "uniprot_id": "KTDAP_MOUSE", "mass": 11497.0, "length": 102, "protein_name": "Keratinocyte differentiation-associated protein", "gene_name": "Krtdap", "organism": "Mouse", "refseq_name": "keratinocyte differentiation-associated protein isoform 1 precursor", "refseq_ac": "NP_001028303", "gene_names_uniprotkb": "Krtdap; Kdap", "gene_names_refseq": "Kdap; Krtdap; sk221", "protein_names_uniprotkb": "Keratinocyte differentiation-associated protein", "protein_names_refseq": "keratinocyte differentiation-associated protein isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:64661)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15256262;17330888;21750661;30084848", "class_list": "", "function": "Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice., [RefSeq, PubMed]; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNU7;Q3V2T1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0042599 lamellar body;GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3V2T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60651-1", "uniprot_id": "KLRA4_MOUSE", "mass": 30872.0, "length": 263, "protein_name": "Killer cell lectin-like receptor 4", "gene_name": "Klra4", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor 4 isoform 2", "refseq_ac": "NP_001239506", "gene_names_uniprotkb": "Klra4; Ly-49d; Ly49-d; Ly49d", "gene_names_refseq": "Chok; Klra32; Klra33; Klra4; Ly-49d; Ly49d; ly49r<129>", "protein_names_uniprotkb": "Killer cell lectin-like receptor 4; Ly-49d; Lymphocyte antigen 49d; T-cell surface glycoprotein Ly-49D", "protein_names_refseq": "T-cell surface glycoprotein Ly-49D; killer cell lectin-like receptor 4 isoform 2; killer cell lectin-like receptor 4; killer cell lectin-like receptor subfamily A member 32; killer cell lectin-like receptor subfamily A member 33; lymphocyte antigen 49d", "tax_id": 10090, "disease": "", "pathway": " (mmu:16635)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10925254;19247984;27438766;33649389;34418053;8027540;8824161;9647200", "class_list": "glycogene", "function": "Receptor on natural killer (NK) cells for class I MHC., [UniProtKB, PubMed]; These data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells., [RefSeq, PubMed]; This study shows that after mouse cytomegalovirus infection, Ly49D augmented IFN-gamma production by virus-specific Ly49H(+) NK cells and preferentially promoted the generation of memory Ly49H(+) NK cells, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 112, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O78026;Q9EPA5", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q60651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60653-1", "uniprot_id": "KLRA6_MOUSE", "mass": 31269.0, "length": 266, "protein_name": "Killer cell lectin-like receptor 6", "gene_name": "Klra6", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor 6", "refseq_ac": "NP_032490", "gene_names_uniprotkb": "Klra6; Ly-49f; Ly49-f; Ly49F", "gene_names_refseq": "Klra6; Ly49f; ly-49f", "protein_names_uniprotkb": "Killer cell lectin-like receptor 6; Ly-49f; Lymphocyte antigen 49f; T-cell surface glycoprotein Ly-49F", "protein_names_refseq": "T-cell surface glycoprotein Ly-49F; killer cell lectin-like receptor 6; lymphocyte antigen 49f", "tax_id": 10090, "disease": "", "pathway": " (mmu:16637)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "36210013;8027540", "class_list": "", "function": "Receptor on natural killer (NK) cells for class I MHC., [UniProtKB]; This gene belongs to the highly polymorphic family of C-type lectin-like Ly49 genes that are expressed in natural killer (NK) cells. The encoded protein is a homodimeric type II transmembrane receptor located at the cell surface and inhibits NK cell activation upon ligand binding. This gene is located in a cluster of several Klra paralogs on chromosome 6. Different strains of mice show variation in the number of paralogs, including strain specific duplications, deletions and pseudogene sequences. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60653-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60660-1", "uniprot_id": "KLRA2_MOUSE", "mass": 33607.0, "length": 288, "protein_name": "Killer cell lectin-like receptor 2", "gene_name": "Klra2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Klra2; Ly49-b; Ly49b", "gene_names_refseq": "", "protein_names_uniprotkb": "Killer cell lectin-like receptor 2; Ly-49b; Lymphocyte antigen 49b; T-cell surface glycoprotein Ly-49B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:16633)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;1869832;21750661", "class_list": "glycogene", "function": "Receptor on natural killer (NK) cells for class I MHC., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60660-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60682-1", "uniprot_id": "KLRA8_MOUSE", "mass": 31393.0, "length": 266, "protein_name": "Killer cell lectin-like receptor 8", "gene_name": "Klra8", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor 8 isoform 1", "refseq_ac": "NP_001095090", "gene_names_uniprotkb": "Klra8; Ly-49h; Ly49-h; Ly49H", "gene_names_refseq": "Cmv-1; Cmv1; Klra8; Ly49h; Ly49u<129>", "protein_names_uniprotkb": "Killer cell lectin-like receptor 8; Ly-49h; Lymphocyte antigen 49h; T-cell surface glycoprotein Ly-49H", "protein_names_refseq": "T-cell surface glycoprotein Ly-49H; cytomegalovirus resistance 1; killer cell lectin-like receptor 8 isoform 1; killer cell lectin-like receptor 8; ly-49h; lymphocyte antigen 49h", "tax_id": 10090, "disease": "", "pathway": " (mmu:16639)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12060703;14597723;17182575;17537914;18566392;23666294;7964501;8824161;9647200", "class_list": "glycogene", "function": "Receptor on natural killer (NK) cells for class I MHC., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 92, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O78027", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q60682-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60860-1", "uniprot_id": "LTC4S_MOUSE", "mass": 16814.0, "length": 150, "protein_name": "Leukotriene C4 synthase", "gene_name": "Ltc4s", "organism": "Mouse", "refseq_name": "leukotriene C4 synthase isoform 1", "refseq_ac": "NP_032547", "gene_names_uniprotkb": "Ltc4s", "gene_names_refseq": "Ltc4s", "protein_names_uniprotkb": "Leukotriene C4 synthase; 2.5.1.-; 4.4.1.20; Glutathione S-transferase LTC4; LTC4 synthase; Leukotriene-C(4) synthase", "protein_names_refseq": "LTC4 synthase; glutathione S-transferase LTC4; leukotriene C4 synthase isoform 1; leukotriene-C(4) synthase", "tax_id": 10090, "disease": "aspirin allergy (Disease Ontology:DOID:0040002); sinusitis (Disease Ontology:DOID:0050127); obstructive sleep apnea (Disease Ontology:DOID:0050848); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); allergic disease (Disease Ontology:DOID:1205); urticaria (Disease Ontology:DOID:1555); intrahepatic cholestasis (Disease Ontology:DOID:1852); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); cerebral infarction (Disease Ontology:DOID:3526); allergic rhinitis (Disease Ontology:DOID:4481); peripheral nervous system disease (Disease Ontology:DOID:574); periodontitis (Disease Ontology:DOID:824); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:17001); (R-MMU-2142688); (R-MMU-2142691); (R-MMU-2142700); (R-MMU-9026762); (R-MMU-9026766)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "11319240;11748223;21750661;31219806;7766706;8706658;9342232", "class_list": "", "function": "Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:11319240, PubMed:8706658). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]; These results suggest that LTC(4) synthase, thought to be specific for the conjugation of GSH to LTA(4), can also recognize 5-oxoETE as an electrophilic substrate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVR7;Q9QVS1", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.13.11.-;1.13.11.34;2.5.1.-", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0006691 leukotriene metabolic process;GO:0019370 leukotriene biosynthetic process;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60860-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64281-1", "uniprot_id": "LRB4A_MOUSE", "mass": 37544.0, "length": 335, "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 4A", "gene_name": "Gm49339; Lilrb4a", "organism": "Mouse", "refseq_name": "leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 1 precursor", "refseq_ac": "NP_038560", "gene_names_uniprotkb": "Gm49339; Lilrb4a; Gp49b", "gene_names_refseq": "CD85K; Gp49b; HM18; ILT3; LIR-5; Lilrb4a; Lilrb4; gp49", "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily B member 4A; Mast cell surface glycoprotein Gp49B", "protein_names_refseq": "glycoprotein 49 B; leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 1 precursor; leukocyte immunoglobulin-like receptor, subfamily B, member 4; mast cell surface glycoprotein Gp49B", "tax_id": 10090, "disease": "", "pathway": " (mmu:14728)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10026201;10982834;11323698;11457897;12682239;12884301;14557414;17761953;18792399;19144319;21750661;24935931;34089617;37461040;38232701;38636927;38971897;8132564;8855262;8977169;8977170;9338594;9422771;9973385", "class_list": "", "function": "Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors., [RefSeq, PubMed]; Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:10026201, PubMed:11323698, PubMed:11457897, PubMed:8855262). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; LILRB4 knockdown inhibits aortic dissection development by regulating pyroptosis and the JAK2/STAT3 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection. Publication Status: Online-Only, [RefSeq, PubMed]; Leukocyte Ig-like receptor B4 (Lilrb4a) alleviates cardiac dysfunction and isoproterenol-induced arrhythmogenic remodeling associated with cardiac fibrosis and inflammation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q64312", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005178 integrin binding;GO:0019903 protein phosphatase binding;GO:0001968 fibronectin binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0051707 response to other organism;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0002437 inflammatory response to antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q64281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64329-1", "uniprot_id": "KLRA3_MOUSE", "mass": 31311.0, "length": 266, "protein_name": "Killer cell lectin-like receptor 3", "gene_name": "Klra3", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor 3", "refseq_ac": "NP_001276533", "gene_names_uniprotkb": "Klra3; Ly-49c; Ly49C", "gene_names_refseq": "5E6; Klra3; Ly49c; NK-2.1; Nk-2; Nk2.1; Nk2", "protein_names_uniprotkb": "Killer cell lectin-like receptor 3; 5E6; Ly-49c; Lymphocyte antigen 49c; Nk2.1; T-cell surface glycoprotein Ly-49C", "protein_names_refseq": "T-cell surface glycoprotein Ly-49C; killer cell lectin-like receptor 3; lymphocyte antigen 49c; natural killer cell-associated antigen 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16634); (mmu:16640)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11777974;14595439;18426793;1869832;23666294;27385590;30249666;30381460;33891944;7629496;8892625;8976165", "class_list": "glycogene", "function": "Clearance of lung cancer is facilitated by up-regulation of NKG2D, NKp46, and other activating receptors upon exposure to environmental MHCI. Surface expression of the inhibitory receptor Ly49C/I, on the other hand, is down-regulated upon exposure to tumor-bearing tissue., [RefSeq, PubMed]; Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor., [RefSeq, PubMed]; Receptor on natural killer (NK) cells for class I MHC., [UniProtKB, PubMed]; The Ly49 family of class I MHC receptors have critical role for adaptive natural killer cell responses., [RefSeq, PubMed]; This docking mode was conserved with that previously observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar energetic footprints focused around residues located within the Ly49C beta4-stand and L5 loop, which contact the underside of the peptide-binding platform floor., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 53, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWQ1;Q3ZB40;Q499I4;Q61154;Q61198;Q64257", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q64329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZK5-1", "uniprot_id": "KLH14_MOUSE", "mass": 70953.0, "length": 630, "protein_name": "Kelch-like protein 14", "gene_name": "Klhl14", "organism": "Mouse", "refseq_name": "kelch-like protein 14", "refseq_ac": "NP_001074872", "gene_names_uniprotkb": "Klhl14; Kiaa1384", "gene_names_refseq": "6330403N15Rik; Klhl14; printor", "protein_names_uniprotkb": "Kelch-like protein 14; Printor; Protein interactor of Torsin-1A; Protein interactor of torsinA", "protein_names_refseq": "kelch-like protein 14; protein interactor of Torsin-1A; protein interactor of torsinA", "tax_id": 10090, "disease": "", "pathway": " (mmu:225266)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19535332;29939266;30084848;30779550;34686337", "class_list": "", "function": "Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting., [RefSeq, PubMed]; KLHL14 promotes B-1a development in mice, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CU51", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q69ZK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NVG1-1", "uniprot_id": "LPCT4_MOUSE", "mass": 57143.0, "length": 524, "protein_name": "Lysophospholipid acyltransferase LPCAT4", "gene_name": "Lpcat4", "organism": "Mouse", "refseq_name": "lysophospholipid acyltransferase LPCAT4", "refseq_ac": "NP_997089", "gene_names_uniprotkb": "Lpcat4; Agpat7; Aytl3", "gene_names_refseq": "Agpat7; Aytl3; LPEAT2; Lpcat4", "protein_names_uniprotkb": "Lysophospholipid acyltransferase LPCAT4; 1-AGP acyltransferase 7; 1-AGPAT 7; 1-acylglycerol-3-phosphate O-acyltransferase 7; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 1-alkenylglycerophosphoethanolamine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.121; 2.3.1.23; 2.3.1.67; 2.3.1.n6; 2.3.1.n7; Acyltransferase-like 3; Lysophosphatidylcholine acyltransferase 4; Lysophosphatidylethanolamine acyltransferase 2; Plasmalogen synthase", "protein_names_refseq": "-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); 1-AGP acyltransferase 7; 1-AGPAT 7; 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 1-alkenylglycerophosphoethanolamine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; acyltransferase-like 3; lysophosphatidylethanolamine acyltransferase 2; lysophospholipid acyltransferase LPCAT4; plasmalogen synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:99010); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "18156367;18458083;31219806;32204912;38226852", "class_list": "", "function": "Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity). Converts lysophosphatidylcholine to phosphatidycholine (PubMed:18156367)., [UniProtKB, PubMed, UniProtKB]; Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2) incorporates DHA into phospholipids and has possible functions for fatty acid-induced cell death., [RefSeq, PubMed]; Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66JP7", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.51;2.3.1.67;2.3.1.25;2.3.1.-;2.3.1.121;2.3.1.n6;2.3.1.n7;2.3.1.15;2.3.1.22;2.3.1.62", "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0047166 1-alkenylglycerophosphoethanolamine O-acyltransferase activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006644 phospholipid metabolic process;GO:0008654 phospholipid biosynthetic process;GO:0036150 phosphatidylserine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NVG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TDP3-1", "uniprot_id": "KLH17_MOUSE", "mass": 69732.0, "length": 640, "protein_name": "Kelch-like protein 17", "gene_name": "Klhl17", "organism": "Mouse", "refseq_name": "kelch-like protein 17", "refseq_ac": "NP_938047", "gene_names_uniprotkb": "Klhl17", "gene_names_refseq": "Klhl17", "protein_names_uniprotkb": "Kelch-like protein 17; Actinfilin", "protein_names_refseq": "actinfilin; kelch-like protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:231003)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;31599954;33256713;38898681", "class_list": "", "function": "KLHL17 differentially controls the expression of AMPA- and KA-type glutamate receptors to regulate dendritic spine enlargement., [RefSeq, PubMed]; KLHL17/Actinfilin, a brain-specific gene associated with infantile spasms and autism, regulates dendritic spine enlargement. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0051015 actin filament binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140252 regulation protein catabolic process at postsynapse", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6TDP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSF4-1", "uniprot_id": "LR75A_MOUSE", "mass": 37574.0, "length": 339, "protein_name": "Leucine-rich repeat-containing protein 75A", "gene_name": "Lrrc75a", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 75A isoform 1", "refseq_ac": "NP_942561", "gene_names_uniprotkb": "Lrrc75a; Fam211a", "gene_names_refseq": "Fam211a; Lrrc75a", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 75A; Leucine-rich repeat-containing protein FAM211A", "protein_names_refseq": "family with sequence similarity 211, member A; leucine-rich repeat-containing protein 75A isoform 1; leucine-rich repeat-containing protein 75A; leucine-rich repeat-containing protein C17orf76 homolog; leucine-rich repeat-containing protein FAM211A", "tax_id": 10090, "disease": "", "pathway": " (mmu:192976)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19144319;21183079", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIX7;Q811G5", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TSF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TF4-1", "uniprot_id": "KLH13_MOUSE", "mass": 73787.0, "length": 654, "protein_name": "Kelch-like protein 13", "gene_name": "Klhl13", "organism": "Mouse", "refseq_name": "kelch-like protein 13 isoform 2", "refseq_ac": "NP_001277405", "gene_names_uniprotkb": "Klhl13; Bklhd2; Kiaa1309", "gene_names_refseq": "1200009K10Rik; Bklhd2; D130072F20Rik; Klhl13", "protein_names_uniprotkb": "Kelch-like protein 13; BTB and kelch domain-containing protein 2", "protein_names_refseq": "BTB and kelch domain-containing protein 2; kelch-like protein 13 isoform 2; kelch-like protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:67455); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19892989;30779550;34428180", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AL86;A2AL87;A2AL88;A2AL89;Q9DBY7", "ec_number_list": "", "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80TF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGB5-1", "uniprot_id": "LIMD2_MOUSE", "mass": 14237.0, "length": 128, "protein_name": "LIM domain-containing protein 2", "gene_name": "Limd2", "organism": "Mouse", "refseq_name": "LIM domain-containing protein 2", "refseq_ac": "NP_765985", "gene_names_uniprotkb": "Limd2", "gene_names_refseq": "0610025L06Rik; Limd2", "protein_names_uniprotkb": "LIM domain-containing protein 2", "protein_names_refseq": "LIM domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67803)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26495903;34428180", "class_list": "", "function": "Acts as an activator of the protein-kinase ILK, thereby regulating cell motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM86-1", "uniprot_id": "LHPL6_MOUSE", "mass": 21626.0, "length": 200, "protein_name": "LHFPL tetraspan subfamily member 6 protein", "gene_name": "Lhfpl6", "organism": "Mouse", "refseq_name": "LHFPL tetraspan subfamily member 6 protein precursor", "refseq_ac": "NP_780595", "gene_names_uniprotkb": "Lhfpl6; Lhfp", "gene_names_refseq": "2810489O06Rik; Lhfpl6; Lhfp", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 6 protein; Lipoma HMGIC fusion partner", "protein_names_refseq": "LHFPL tetraspan subfamily member 6 protein precursor; LHFPL tetraspan subfamily member 6 protein; lipoma HMGIC fusion partner", "tax_id": 10090, "disease": "", "pathway": " (mmu:108927)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31042701", "class_list": "", "function": "Lhfp is a regulator of osteoblast activity and bone mass. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9G7;Q3TWU2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BM86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMC0-1", "uniprot_id": "LPAR6_MOUSE", "mass": 39439.0, "length": 344, "protein_name": "Lysophosphatidic acid receptor 6", "gene_name": "Lpar6", "organism": "Mouse", "refseq_name": "lysophosphatidic acid receptor 6", "refseq_ac": "NP_780325", "gene_names_uniprotkb": "Lpar6; P2ry5; P2y5", "gene_names_refseq": "2610302I02Rik; Lpar6; P2ry5; P2y5", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5", "protein_names_refseq": "LPA receptor 6; LPA-6; P2Y purinoceptor 5; lysophosphatidic acid receptor 6; oleoyl-L-alpha-lysophosphatidic acid receptor; purinergic receptor (family A group 5); purinergic receptor 5; purinergic receptor P2Y, G-protein coupled, 5", "tax_id": 10090, "disease": "hypotrichosis 8 (Disease Ontology:DOID:0110705)", "pathway": " (mmu:67168); (R-MMU-416476); (R-MMU-417957)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18297070;18297072;25605945", "class_list": "", "function": "Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6H6N5;Q3TEJ6", "ec_number_list": "", "go_molecular_function": "GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BMC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4N4-1", "uniprot_id": "LAAT1_MOUSE", "mass": 32200.0, "length": 293, "protein_name": "Lysosomal amino acid transporter 1 homolog", "gene_name": "Slc66a1", "organism": "Mouse", "refseq_name": "lysosomal amino acid transporter 1 homolog", "refseq_ac": "NP_663359", "gene_names_uniprotkb": "Slc66a1; Pqlc2", "gene_names_refseq": "Pqlc2; Slc66a1", "protein_names_uniprotkb": "Lysosomal amino acid transporter 1 homolog; PQ-loop repeat-containing protein 2; Solute carrier family 66 member 1", "protein_names_refseq": "PQ loop repeat containing 2; PQ-loop repeat-containing protein 2; lysosomal amino acid transporter 1 homolog", "tax_id": 10090, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:212555); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20173027;21750661;23169667", "class_list": "", "function": "Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R132", "ec_number_list": "", "go_molecular_function": "GO:0015174 basic amino acid transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0015819 lysine transport;GO:0080144 intracellular amino acid homeostasis;GO:0089709 L-histidine transmembrane transport;GO:1903401 L-lysine transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C4N4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C561-1", "uniprot_id": "LMBD2_MOUSE", "mass": 81101.0, "length": 694, "protein_name": "G protein-coupled receptor-associated protein LMBRD2", "gene_name": "Lmbrd2", "organism": "Mouse", "refseq_name": "G-protein coupled receptor-associated protein LMBRD2 isoform 1", "refseq_ac": "NP_796152", "gene_names_uniprotkb": "Lmbrd2", "gene_names_refseq": "9930036E21Rik; Lmbrd2", "protein_names_uniprotkb": "G protein-coupled receptor-associated protein LMBRD2; LMBR1 domain-containing protein 2", "protein_names_refseq": "G-protein coupled receptor-associated protein LMBRD2 isoform 1; G-protein coupled receptor-associated protein LMBRD2; LMBR1 domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320506)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;25428506;31219806;34428180", "class_list": "", "function": "Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G protein-coupled receptors including type-1 angiotensin II receptor/AGTR1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9552, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5C1;Q501M6;Q8BQ06", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071875 adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C8H8-1", "uniprot_id": "KY_MOUSE", "mass": 75090.0, "length": 661, "protein_name": "Kyphoscoliosis peptidase", "gene_name": "Ky", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ky", "gene_names_refseq": "", "protein_names_uniprotkb": "Kyphoscoliosis peptidase; 3.4.-.-", "protein_names_refseq": "", "tax_id": 10090, "disease": "myofibrillar myopathy 7 (Disease Ontology:DOID:0080098)", "pathway": " (mmu:16716)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11136708;15385448;16622832;20206623;21750661;34428180;36210013", "class_list": "", "function": "Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPK9", "ec_number_list": "", "go_molecular_function": "GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030018 Z disc", "go_biological_process": "GO:0006508 proteolysis;GO:0007528 neuromuscular junction development;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C8H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CF66-1", "uniprot_id": "LTOR4_MOUSE", "mass": 10678.0, "length": 99, "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "Lamtor4", "organism": "Mouse", "refseq_name": "ragulator complex protein LAMTOR4", "refseq_ac": "NP_001074577", "gene_names_uniprotkb": "Lamtor4", "gene_names_refseq": "0910001L09Rik; Lamtor4", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR4; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4", "protein_names_refseq": "UPF0539 protein C7orf59 homolog; late endosomal/lysosomal adaptor and MAPK and MTOR activator 4; ragulator complex protein LAMTOR4", "tax_id": 10090, "disease": "", "pathway": " (mmu:66096); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN18;Q8CEW4;Q8CF77", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0071986 Ragulator complex;GO:1990877 FNIP-folliculin RagC/D GAP", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032008 positive regulation of TOR signaling;GO:0038202 TORC1 signaling;GO:0071230 cellular response to amino acid stimulus;GO:0061462 protein localization to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CF66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGK3-1", "uniprot_id": "LONM_MOUSE", "mass": 105843.0, "length": 949, "protein_name": "Lon protease homolog, mitochondrial", "gene_name": "Lonp1", "organism": "Mouse", "refseq_name": "lon protease homolog, mitochondrial precursor", "refseq_ac": "NP_083058", "gene_names_uniprotkb": "Lonp1; Prss15", "gene_names_refseq": "1200017E13Rik; LON; Lonp1; Prss15", "protein_names_uniprotkb": "Lon protease homolog, mitochondrial; 3.4.21.53; 3.6.4.10; LONP; Lon protease-like protein; Mitochondrial ATP-dependent protease Lon; Mitochondrial chaperone LONP1; Serine protease 15", "protein_names_refseq": "LONP; lon protease homolog, mitochondrial precursor; lon protease homolog, mitochondrial; lon protease-like protein; mitochondrial ATP-dependent protease Lon; protease, serine, 15; serine protease 15", "tax_id": 10090, "disease": "CODAS syndrome (Disease Ontology:DOID:0111274); brain ischemia (Disease Ontology:DOID:2316); ischemia (Disease Ontology:DOID:326)", "pathway": " (mmu:74142); (R-MMU-9837999)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12372343;12459471;12657466;21750661;34105348;34428180;36288343;37453647;37507081;38625722;39261902;39627609", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. In addtion to its protease activity, has also an ATP-dependent protein folding chaperone activity and functions in mitochondrial protein folding. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters., [UniProtKB, HAMAP, PubMed, UniProtKB]; Aging of alveolar type 2 cells induced by Lonp1 deficiency exacerbates pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Epidermal growth factor up-regulates the transcription of ATP-dependent protease through extracellular signal-regulated protein kinase- and 1-phosphatidylinositol 3-kinase-dependent pathways., [RefSeq, PubMed]; LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis., [RefSeq, PubMed]; Modulation of Lon protease activity during aging and oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSK9;Q3TVL2;Q3TXE4;Q3TZW3;Q9DBP9", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.5.3.1;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.-.-;5.3.3.21;7.6.2.1;3.6.1.5;3.1.2.-;3.1.2.2;3.4.24.-;3.6.-.-;1.1.1.37;3.1.3.1;3.9.1.1;3.6.1.-;4.98.1.1;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;1.4.1.3;5.3.3.8;3.6.4.6;1.2.1.3;2.3.1.168;2.3.3.10;7.1.2.2;3.6.5.-;5.6.1.7;3.6.1.15;3.1.4.-;4.2.1.2;5.6.2.-;7.2.2.-;7.6.2.16;1.2.4.2;1.1.98.-;2.7.11.2;6.1.1.5;2.7.1.23;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.3.1.9;2.7.4.3;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;2.1.2.1;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;1.2.4.1;2.8.3.5;2.3.1.41;1.3.8.5;1.3.8.1", "go_molecular_function": "GO:0001018 mitochondrial promoter sequence-specific DNA binding;GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006508 proteolysis;GO:0001666 response to hypoxia;GO:0050730 regulation of peptidyl-tyrosine phosphorylation;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CGK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI70-1", "uniprot_id": "LRC20_MOUSE", "mass": 20809.0, "length": 184, "protein_name": "Leucine-rich repeat-containing protein 20", "gene_name": "Lrrc20", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 20", "refseq_ac": "NP_705770", "gene_names_uniprotkb": "Lrrc20", "gene_names_refseq": "Lrrc20", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 20", "protein_names_refseq": "leucine-rich repeat-containing protein 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:216011)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CI70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZS0-1", "uniprot_id": "LIN7A_MOUSE", "mass": 25993.0, "length": 233, "protein_name": "Protein lin-7 homolog A", "gene_name": "Lin7a", "organism": "Mouse", "refseq_name": "protein lin-7 homolog A isoform 1", "refseq_ac": "NP_001034443", "gene_names_uniprotkb": "Lin7a; Mals1; Veli1", "gene_names_refseq": "LIN-7A; Lin7a; MALS-1; TIP-33; Veli1; Veli", "protein_names_uniprotkb": "Protein lin-7 homolog A; Lin-7A; MALS-1; Mammalian lin-seven protein 1; Veli-1; Vertebrate lin-7 homolog 1; mLin-7", "protein_names_refseq": "lin 7 homolog a; mammalian LIN-7 1; mammalian lin-seven protein 1; protein lin-7 homolog A isoform 1; protein lin-7 homolog A; vertebrate homolog of C. elegans Lin-7 type 1; vertebrate lin-7 homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:108030); (R-MMU-212676)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10846156;10921879;14622577;15466885;15494546;22645316;22767515;22872234;32848054;34428180;36210013", "class_list": "", "function": "LIN7 is a novel regulator of IRSp53., [RefSeq, PubMed]; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0030165 PDZ domain binding;GO:0097016 L27 domain binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0048839 inner ear development;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8JZS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K097-1", "uniprot_id": "LFG2_MOUSE", "mass": 35258.0, "length": 317, "protein_name": "Protein lifeguard 2", "gene_name": "Faim2", "organism": "Mouse", "refseq_name": "protein lifeguard 2 isoform 2", "refseq_ac": "NP_001033747", "gene_names_uniprotkb": "Faim2; Kiaa0950; Lfg2; Lfg; Nmp35", "gene_names_refseq": "2900002L20Rik; Faim2; Lfg2; Lfg; NMP25; Nmp35; Tmbim2", "protein_names_uniprotkb": "Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35", "protein_names_refseq": "neural membrane protein 35; protein lifeguard 2 isoform 2; protein lifeguard 2", "tax_id": 10090, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:72393)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17635665;19784873;21209208;21957071;23029562;28708137;29315561", "class_list": "", "function": "Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development., [UniProtKB, PubMed, PubMed, PubMed]; Expression of Faim2 is triggered, at least in part, by Fas-receptor activation and subsequent ERK signaling., [RefSeq, PubMed]; Faim2 up-regulation may contribute to the neuroprotective effects of low-dose erythropoietin in transient brain ischemia, [RefSeq, PubMed]; LFG is an endogenous inhibitor of FasL-mediated neuronal death detected in lipid rafts microdomains, and it mediates the FasL resistance of CNS differentiated neurons, [RefSeq, PubMed]; Mechanism of action of LFG as an inhibitor of the Fas pathway and evidence of the neuroprotective role of LFG in cerebellar granule neurons and Purkinje cells in an organotypic cerebellar culture system Erratum:[Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11906], [RefSeq, PubMed]; That FAIM2 is an intrinsic neuroprotective factor activated by stress in photoreceptors and delays FAS-mediated photoreceptor apoptosis, [RefSeq, PubMed]; This study demonistrated that lack of Faim2 caused an increase in susceptibility to combined oxygen-glucose deprivation in primary neurons as well as in caspase-associated cell death, stroke volume, and neurological impairment after cerebral ischemia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY22;Q8K1F6;Q9D6K4", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0021681 cerebellar granular layer development;GO:0002931 response to ischemia;GO:0006915 apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0021680 cerebellar Purkinje cell layer development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K274-1", "uniprot_id": "KT3K_MOUSE", "mass": 34468.0, "length": 309, "protein_name": "Ketosamine-3-kinase", "gene_name": "Fn3krp", "organism": "Mouse", "refseq_name": "ketosamine-3-kinase", "refseq_ac": "NP_852085", "gene_names_uniprotkb": "Fn3krp", "gene_names_refseq": "FN3K-RP; Fn3krp", "protein_names_uniprotkb": "Ketosamine-3-kinase; 2.7.1.-; 2.7.1.172; FN3K-RP; FN3K-related protein; Fructosamine-3-kinase-related protein; Protein-psicosamine 3-kinase FN3KRP", "protein_names_refseq": "FN3K-related protein; ketosamine-3-kinase; ortholog of human fructosamine-3-kinase-related protein FN3KRP; protein-psicosamine 3-kinase FN3KRP", "tax_id": 10090, "disease": "", "pathway": " (mmu:238024); (R-MMU-163841)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14633848;15331600;25428506", "class_list": "", "function": "Fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate, [RefSeq, PubMed]; Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848). Not able to phosphorylate fructoselysine (PubMed:14633848)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATT5", "ec_number_list": "2.7.1.-;2.7.1.172;2.7.1.171", "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0102193 protein-ribulosamine 3-kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0036528 peptidyl-lysine deglycation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K274-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDQ9-1", "uniprot_id": "KRI1_MOUSE", "mass": 82057.0, "length": 704, "protein_name": "Protein KRI1 homolog", "gene_name": "Kri1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kri1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein KRI1 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:215194)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;19144319;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VDQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V13-1", "uniprot_id": "LEAP2_MOUSE", "mass": 8536.0, "length": 76, "protein_name": "Liver-expressed antimicrobial peptide 2", "gene_name": "Leap2", "organism": "Mouse", "refseq_name": "liver-expressed antimicrobial peptide 2 precursor", "refseq_ac": "NP_694709", "gene_names_uniprotkb": "Leap2", "gene_names_refseq": "Leap2; leap-2", "protein_names_uniprotkb": "Liver-expressed antimicrobial peptide 2; LEAP-2", "protein_names_refseq": "liver-expressed antimicrobial peptide 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:259301); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12493837;29233536;31424424;31469195;37414204;38641041;39292603;39331742;39433849", "class_list": "", "function": "Decoding the influence of central LEAP2 on food intake and its effect on accumbal dopamine release., [RefSeq, PubMed]; Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model., [RefSeq, PubMed]; Has an antimicrobial activity., [UniProtKB]; Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of GHSR., [RefSeq, PubMed]; Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of LEAP-2 alleviates obesity-induced myocardial injury by regulating macrophage polarization., [RefSeq, PubMed]; Plasma LEAP2/acyl-ghrelin molar ratio may be a key determinant modulating acyl-ghrelin activity in response to body mass, feeding status, and blood glucose., [RefSeq, PubMed]; The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner. Publication Status: Online-Only, [RefSeq, PubMed]; The LEAP2 Response to Cancer-Related Anorexia-Cachexia Syndrome in Male Mice and Patients., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBH6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0042742 defense response to bacterium;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91V13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WN4-1", "uniprot_id": "KMO_MOUSE", "mass": 54532.0, "length": 479, "protein_name": "Kynurenine 3-monooxygenase", "gene_name": "Kmo", "organism": "Mouse", "refseq_name": "kynurenine 3-monooxygenase", "refseq_ac": "NP_598570", "gene_names_uniprotkb": "Kmo", "gene_names_refseq": "Kmo", "protein_names_uniprotkb": "Kynurenine 3-monooxygenase; 1.14.13.9; Kynurenine 3-hydroxylase", "protein_names_refseq": "kynurenine 3-hydroxylase; kynurenine 3-monooxygenase", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:98256); (R-MMU-71240)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19000912;23568529;26752518;30084848;31219806;34428180;37453647", "class_list": "", "function": "Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract., [UniProtKB, HAMAP, PubMed]; Expression of KMO by Th17 cells serves to limit their continuous exposure to physiological levels of endogenous aryl hydrocarbon receptor ligands in vivo., [RefSeq, PubMed]; Partial protection against cerebral malaria was observed in C57BL/6 mice treated with Ro 61-8048, an inhibitor of kynurenine-3-hydroxylase. Protection was associated with suppressed levels of picolinic acid within the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.13.9", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004502 kynurenine 3-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1903296 positive regulation of glutamate secretion, neurotransmission;GO:0097052 L-kynurenine metabolic process;GO:0006569 L-tryptophan catabolic process;GO:0070189 kynurenine metabolic process;GO:0014049 positive regulation of glutamate secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91WN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M73-1", "uniprot_id": "KRT84_MOUSE", "mass": 64983.0, "length": 603, "protein_name": "Keratin, type II cuticular Hb4", "gene_name": "Krt84", "organism": "Mouse", "refseq_name": "keratin, type II cuticular Hb4", "refseq_ac": "NP_032500", "gene_names_uniprotkb": "Krt84; Krt2-16; Krthb4", "gene_names_refseq": "HRb-1; Krt2-16; Krt2-3; Krt84", "protein_names_uniprotkb": "Keratin, type II cuticular Hb4; 65 kDa type II keratin; K84; Keratin-84; Type II hair keratin Hb4; Type-II keratin Kb24", "protein_names_refseq": "65 kDa type II keratin; K84; keratin complex 2, basic, gene 16; keratin complex 2, gene 16; keratin, type II cuticular Hb4; type II hair keratin Hb4; type-II keratin Kb24", "tax_id": 10090, "disease": "", "pathway": " (mmu:16680); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11445569;12399393;1385239;34428180;37738023", "class_list": "", "function": "E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84., [RefSeq, PubMed]; Structural component of intermediate filaments in keratinizing epithelia (By similarity). As a type II hair keratin, forms obligate heterodimers with type I keratins to assemble keratin intermediate filaments (By similarity). Expressed predominantly in the posterior compartment of the filiform papillae of the tongue, where it contributes to the structural integrity and mechanical resilience of specialized keratinized epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMQ6;Q1RME6;Q61862", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0045616 regulation of keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99M73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M74-1", "uniprot_id": "KRT82_MOUSE", "mass": 57140.0, "length": 516, "protein_name": "Keratin, type II cuticular Hb2", "gene_name": "Krt82", "organism": "Mouse", "refseq_name": "keratin, type II cuticular Hb2", "refseq_ac": "NP_444479", "gene_names_uniprotkb": "Krt82; Krt2-20; Krthb2", "gene_names_refseq": "Krt2-20; Krt82", "protein_names_uniprotkb": "Keratin, type II cuticular Hb2; K82; Keratin-82; Type II hair keratin Hb2; Type-II keratin Kb22", "protein_names_refseq": "K82; keratin complex 2, basic, gene 20; keratin, type II cuticular Hb2; type II hair keratin Hb2; type-II keratin Kb22", "tax_id": 10090, "disease": "", "pathway": " (mmu:114566); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12399393;28011936;34428180;36583994", "class_list": "", "function": "Structural component of intermediate filaments in the hair follicle. As a type II hair keratin, forms obligate heterodimers with type I hair keratins that assemble into keratin intermediate filaments. Expressed specifically in cuticle-forming cells of the hair shaft during the anagen phase, where it contributes to the formation and structural integrity of the hair cuticle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32MV2", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99M74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPP7-1", "uniprot_id": "LIPF_MOUSE", "mass": 44637.0, "length": 395, "protein_name": "Gastric triacylglycerol lipase", "gene_name": "Lipf", "organism": "Mouse", "refseq_name": "gastric triacylglycerol lipase precursor", "refseq_ac": "NP_080610", "gene_names_uniprotkb": "Lipf", "gene_names_refseq": "2310051B21Rik; Lipf", "protein_names_uniprotkb": "Gastric triacylglycerol lipase; 3.1.1.3; GL; Gastric lipase", "protein_names_refseq": "GL; gastric lipase; gastric triacylglycerol lipase precursor; gastric triacylglycerol lipase; lipase, gastric", "tax_id": 10090, "disease": "", "pathway": " (mmu:67717); (R-MMU-192456)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (By similarity). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK78;Q9CPP8;Q9D6L1;Q9D6L9;Q9D6M9;Q9D6N8;Q9D6P3;Q9D6Q2;Q9D6Q3;Q9D6Q6;Q9D6S5;Q9D6T5;Q9D6X0;Q9D760;Q9D766;Q9D767;Q9D796;Q9D798;Q9D7C5", "ec_number_list": "3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.13;3.1.1.6;3.1.1.-;3.1.1.116;2.3.1.51", "go_molecular_function": "GO:0004806 triacylglycerol lipase activity;GO:0016615 malate dehydrogenase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CPP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ74-1", "uniprot_id": "LERL1_MOUSE", "mass": 14414.0, "length": 131, "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "Leprotl1", "organism": "Mouse", "refseq_name": "leptin receptor overlapping transcript-like 1", "refseq_ac": "NP_080885", "gene_names_uniprotkb": "Leprotl1", "gene_names_refseq": "1110067H13Rik; 1520402O14Rik; Leprotl1", "protein_names_uniprotkb": "Leptin receptor overlapping transcript-like 1; Endospanin-2", "protein_names_refseq": "endospanin-2; leptin receptor overlapping transcript-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68192)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19907080;27807798", "class_list": "", "function": "Both LEPROT and LEPROTL1 expression were regulated in liver by physiologic and pathologic changes in glucose homeostasis, [RefSeq, PubMed]; Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1. Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively., [RefSeq, PubMed]; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U662", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQ74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYI4-1", "uniprot_id": "LUC7L_MOUSE", "mass": 43934.0, "length": 371, "protein_name": "Putative RNA-binding protein Luc7-like 1", "gene_name": "Luc7l", "organism": "Mouse", "refseq_name": "putative RNA-binding protein Luc7-like 1 isoform 1", "refseq_ac": "NP_080157", "gene_names_uniprotkb": "Luc7l", "gene_names_refseq": "1810045C04Rik; 2410018D03Rik; Luc7l", "protein_names_uniprotkb": "Putative RNA-binding protein Luc7-like 1", "protein_names_refseq": "Luc7 homolog-like; putative RNA-binding protein Luc7-like 1 isoform 1; putative RNA-binding protein Luc7-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66978)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15474286;21750661;29187734;34428180", "class_list": "", "function": "Luc7l is thought to play an important role in the regulation of muscle differentiation., [RefSeq, PubMed]; May bind to RNA via its Arg/Ser-rich domain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K247;Q9CWM1", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0006376 mRNA splice site recognition;GO:0045843 negative regulation of striated muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CYI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5V2-1", "uniprot_id": "KLH10_MOUSE", "mass": 68977.0, "length": 608, "protein_name": "Kelch-like protein 10", "gene_name": "Klhl10", "organism": "Mouse", "refseq_name": "kelch-like protein 10 isoform 1", "refseq_ac": "NP_080003", "gene_names_uniprotkb": "Klhl10", "gene_names_refseq": "4921517C11Rik; Klhl10", "protein_names_uniprotkb": "Kelch-like protein 10", "protein_names_refseq": "kelch-like protein 10 isoform 1; kelch-like protein 10", "tax_id": 10090, "disease": "spermatogenic failure 11 (Disease Ontology:DOID:0070180)", "pathway": " (mmu:66720)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15136734;16162871;34433733", "class_list": "", "function": "Both alleles are required for male fertility and haploinsufficiency prevents genetic transmission of both mutant and WT alleles., [RefSeq, PubMed]; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Required for male fertility., [UniProtKB, PubMed, PubMed]; The I510V mutation in KLHL10 in a patient with oligoasthenoteratozoospermia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVM3;Q9DA07", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0009566 fertilization;GO:0000902 cell morphogenesis;GO:0007286 spermatid development;GO:0048873 homeostasis of number of cells within a tissue;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D5V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7I5-1", "uniprot_id": "LHPP_MOUSE", "mass": 29144.0, "length": 270, "protein_name": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "gene_name": "Lhpp", "organism": "Mouse", "refseq_name": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "refseq_ac": "NP_083885", "gene_names_uniprotkb": "Lhpp", "gene_names_refseq": "2310007H09Rik; Lhpp", "protein_names_uniprotkb": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; 3.1.3.-; 3.6.1.1", "protein_names_refseq": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:76429); (R-MMU-71737)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;36460727;37678540", "class_list": "", "function": "LHPP in Glutamatergic Neurons of the Ventral Hippocampus Mediates Depression-like Behavior by Dephosphorylating CaMKIIalpha and ERK., [RefSeq, PubMed]; LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity., [RefSeq, PubMed]; Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USP1;Q6P070", "ec_number_list": "3.1.3.1;3.9.1.1;3.6.1.1;3.1.3.-", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004427 inorganic diphosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7Z7-1", "uniprot_id": "LYPD5_MOUSE", "mass": 27450.0, "length": 256, "protein_name": "Ly6/PLAUR domain-containing protein 5", "gene_name": "Lypd5", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 5 precursor", "refseq_ac": "NP_084082", "gene_names_uniprotkb": "Lypd5", "gene_names_refseq": "2210003I03Rik; 2310011E23Rik; Lypd5", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 5", "protein_names_refseq": "ly6/PLAUR domain-containing protein 5 precursor; ly6/PLAUR domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:76942); (R-MMU-163125)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDW0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D7Z7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAK8-1", "uniprot_id": "LRC51_MOUSE", "mass": 22008.0, "length": 192, "protein_name": "Leucine-rich repeat-containing protein 51", "gene_name": "Lrrc51", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 51 isoform 2", "refseq_ac": "NP_001156446", "gene_names_uniprotkb": "Lrrc51", "gene_names_refseq": "1700008D07Rik; Lrrc51; Lrtomt", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 51", "protein_names_refseq": "leucine-rich repeat-containing protein 51 isoform 2; leucine-rich repeat-containing protein 51", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 63 (Disease Ontology:DOID:0110515)", "pathway": " (mmu:69358)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18953341;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6CZ58;B6CZ59;Q8R171", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBH5-1", "uniprot_id": "LMAN2_MOUSE", "mass": 40430.0, "length": 358, "protein_name": "Vesicular integral-membrane protein VIP36", "gene_name": "Lman2", "organism": "Mouse", "refseq_name": "vesicular integral-membrane protein VIP36 precursor", "refseq_ac": "NP_080104", "gene_names_uniprotkb": "Lman2", "gene_names_refseq": "1110003H06Rik; 1300009F09Rik; GP36B; Lman2; VIP36", "protein_names_uniprotkb": "Vesicular integral-membrane protein VIP36; Lectin mannose-binding 2; VIP36; Vesicular integral-membrane protein 36", "protein_names_refseq": "vesicular integral-membrane protein 36; vesicular integral-membrane protein VIP36 precursor; vesicular integral-membrane protein VIP36", "tax_id": 10090, "disease": "", "pathway": " (mmu:66890); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;26740625;30899004;34428180;37507081;37828378;40997131", "class_list": "glycogene", "function": "Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJL4;Q9CXG7", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031072 heat shock protein binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0050766 positive regulation of phagocytosis;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9DBH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DD23-1", "uniprot_id": "LYPD2_MOUSE", "mass": 13280.0, "length": 127, "protein_name": "Ly6/PLAUR domain-containing protein 2", "gene_name": "Lypd2", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 2 precursor", "refseq_ac": "NP_080947", "gene_names_uniprotkb": "Lypd2; Lypdc2", "gene_names_refseq": "0610005K03Rik; Lypd2; Lypdc2; VLL", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 2; Protein H8C4", "protein_names_refseq": "H8C4 protein; ly6/PLAUR domain-containing protein 2 precursor; ly6/PLAUR domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68311); (R-MMU-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RT83", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DD23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERE2-1", "uniprot_id": "KRT81_MOUSE", "mass": 52863.0, "length": 481, "protein_name": "Keratin, type II cuticular Hb1", "gene_name": "Krt81", "organism": "Mouse", "refseq_name": "keratin, type II cuticular Hb1", "refseq_ac": "NP_001159629", "gene_names_uniprotkb": "Krt81; Krt2-19", "gene_names_refseq": "Krt2-19; Krt81", "protein_names_uniprotkb": "Keratin, type II cuticular Hb1; K81; Keratin-81; Type II hair keratin Hb1", "protein_names_refseq": "K81; keratin complex 2, basic, gene 19; keratin, type II cuticular Hb1; type II hair keratin Hb1", "tax_id": 10090, "disease": "monilethrix 2 (Disease Ontology:DOID:0061152); breast cancer (Disease Ontology:DOID:1612); hair disease (Disease Ontology:DOID:421)", "pathway": " (mmu:64818); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12399393;29187734", "class_list": "", "function": "Structural component of intermediate filaments in the hair cortex. Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLY5", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ERE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIT0-1", "uniprot_id": "LMBR1_MOUSE", "mass": 55115.0, "length": 490, "protein_name": "Limb region 1 protein", "gene_name": "Lmbr1", "organism": "Mouse", "refseq_name": "limb region 1 protein", "refseq_ac": "NP_064691", "gene_names_uniprotkb": "Lmbr1", "gene_names_refseq": "1110048D14Rik; Lmbr1", "protein_names_uniprotkb": "Limb region 1 protein", "protein_names_refseq": "limb region 1 protein", "tax_id": 10090, "disease": "acheiropody (Disease Ontology:DOID:0050603); preaxial polydactyly II (Disease Ontology:DOID:0060986); bone development disease (Disease Ontology:DOID:0080006); Laurin-Sandrow syndrome (Disease Ontology:DOID:0111350); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818)", "pathway": " (mmu:56873)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10945466;12491086;14727139;21750661", "class_list": "", "function": "Disruption is associated with preaxial polydactyly, [RefSeq, PubMed]; Putative membrane receptor., [UniProtKB]; This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q766D0;Q91WC6;Q9JIS9", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0035116 embryonic hindlimb morphogenesis;GO:0042733 embryonic digit morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JIT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJL9-1", "uniprot_id": "LT4R2_MOUSE", "mass": 37867.0, "length": 360, "protein_name": "Leukotriene B4 receptor 2", "gene_name": "Ltb4r2", "organism": "Mouse", "refseq_name": "leukotriene B4 receptor 2", "refseq_ac": "NP_065236", "gene_names_uniprotkb": "Ltb4r2; Blt2", "gene_names_refseq": "5830462O07Rik; BLT2; LTB4-R 2; LTB4-R-2; LTB4-R2; Ltb4r2", "protein_names_uniprotkb": "Leukotriene B4 receptor 2; LTB4-R 2; LTB4-R2; Leukotriene B4 receptor BLT2", "protein_names_refseq": "leukotriene B4 receptor 2; leukotriene B4 receptor BLT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:57260); (R-MMU-391906); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10934230;12895595;15866883;34635780;34887363;38097183", "class_list": "", "function": "360 amino acid sequence determined and aligned with human sequence Review article, [RefSeq, PubMed]; BLT2 is a leukotriene B4 receptor with a role in ERK activation and cell migration of primary mouse keratinocytes, [RefSeq, PubMed]; Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis., [RefSeq, PubMed]; Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation., [RefSeq, PubMed]; Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation., [RefSeq, PubMed]; Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KP98", "ec_number_list": "", "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0001632 leukotriene B4 receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0051546 keratinocyte migration;GO:0007165 signal transduction;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL06-1", "uniprot_id": "LPAR2_MOUSE", "mass": 39003.0, "length": 348, "protein_name": "Lysophosphatidic acid receptor 2", "gene_name": "Lpar2", "organism": "Mouse", "refseq_name": "lysophosphatidic acid receptor 2", "refseq_ac": "NP_064412", "gene_names_uniprotkb": "Lpar2; Edg4; Lpa2", "gene_names_refseq": "Edg4; IPA2; LPA2; Lpar2", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 2; LPA receptor 2; LPA-2; Lysophosphatidic acid receptor Edg-4", "protein_names_refseq": "LPA receptor 2; LPA-2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4; lysophosphatidic acid receptor 2; lysophosphatidic acid receptor Edg-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:53978); (R-MMU-416476); (R-MMU-418594); (R-MMU-419408)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10729222;11093753;21750661;33427061;35151977;38149778", "class_list": "", "function": "Functional modulation of lysophosphatidic acid type 2 G-protein coupled receptor facilitates alveolar bone formation., [RefSeq, PubMed]; LPA2 promotes neuronal differentiation and neurite formation in neocortical development., [RefSeq, PubMed]; Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion., [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P290", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030165 PDZ domain binding;GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JL06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1R0-1", "uniprot_id": "LHX6_MOUSE", "mass": 40044.0, "length": 363, "protein_name": "LIM/homeobox protein Lhx6", "gene_name": "Lhx6", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx6 isoform 3", "refseq_ac": "NP_001076595", "gene_names_uniprotkb": "Lhx6; Lhx6.1", "gene_names_refseq": "Lhx6.1; Lhx6", "protein_names_uniprotkb": "LIM/homeobox protein Lhx6; LIM homeobox protein 6; LIM/homeobox protein Lhx6.1", "protein_names_refseq": "LIM-homeodomain protein 6.1; LIM/homeobox protein Lhx6 isoform 3; LIM/homeobox protein Lhx6.1; LIM/homeobox protein Lhx6", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:16874)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10393337;10479690;15201337;15944132;17376969;18339674;18613121;21750661;9570771", "class_list": "", "function": "Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88706;Q6P1H2;Q9R1R1", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021877 forebrain neuron fate commitment;GO:0021799 cerebral cortex radially oriented cell migration;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R1R0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2B9-1", "uniprot_id": "KS6A4_MOUSE", "mass": 85652.0, "length": 773, "protein_name": "Ribosomal protein S6 kinase alpha-4", "gene_name": "Rps6ka4", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase alpha-4", "refseq_ac": "NP_064308", "gene_names_uniprotkb": "Rps6ka4; Msk2", "gene_names_refseq": "1110069D02Rik; 90kDa; Msk2; Rps6ka4; mMSK2", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-4; 2.7.11.1; 90 kDa ribosomal protein S6 kinase 4; Nuclear mitogen- and stress-activated protein kinase 2; RLSK; RSK-like protein kinase; S6K-alpha-4", "protein_names_refseq": "90 kDa ribosomal protein S6 kinase 4; RLSK; RSK-like protein kinase; S6K-alpha-4; mitogen- and stress-activated protein kinase-2; nuclear mitogen- and stress-activated protein kinase 2; ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase, 90kD, polypeptide 4; ribosomal protein S6 kinase, polypeptide 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:56613)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11909979;16517600;18690222;21183079;21750661;25605945;27973548;30084848;31219806;34428180;35820727;9687510", "class_list": "", "function": "Chromatin modifier, MSK1/2, has a role in suppressing endocrine and promoting acinar differentiation during pancreatic development Publication Status: Online-Only, [RefSeq, PubMed]; MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts., [RefSeq, PubMed]; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3M8;Q91X18", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0035175 histone H3S10 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0043687 post-translational protein modification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z2B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q3S4-1", "uniprot_id": "M3K19_MOUSE", "mass": 146412.0, "length": 1311, "protein_name": "Mitogen-activated protein kinase kinase kinase 19", "gene_name": "Map3k19", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 19", "refseq_ac": "NP_035867", "gene_names_uniprotkb": "Map3k19; Ysk4", "gene_names_refseq": "Map3k19; Ysk4", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 19; 2.7.11.1; SPS1/STE20-related protein kinase YSK4", "protein_names_refseq": "SPS1/STE20-related protein kinase YSK4; Yeast Sps1/Ste20-related kinase 4; mitogen-activated protein kinase kinase kinase 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:22625)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34418053", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9Q3S4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJ15-1", "uniprot_id": "MA1B1_MOUSE", "mass": 75150.0, "length": 658, "protein_name": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "gene_name": "Man1b1", "organism": "Mouse", "refseq_name": "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "refseq_ac": "NP_001025154", "gene_names_uniprotkb": "Man1b1", "gene_names_refseq": "E430019H13Rik; ERMan1; Gm108; MANA-ER; Man1b1", "protein_names_uniprotkb": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; 3.2.1.113; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1", "protein_names_refseq": "ER alpha-1,2-mannosidase; ER mannosidase 1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; man9GlcNAc2-specific-processing alpha-mannosidase", "tax_id": 10090, "disease": "Rafiq syndrome (Disease Ontology:DOID:0081097)", "pathway": " (mmu:227619)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;25428506;26495903;30084848;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.113;3.2.1.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway;GO:1904380 endoplasmic reticulum mannose trimming;GO:0006491 N-glycan processing;GO:0140277 endoplasmic reticulum N-glycan trimming", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AJ15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AQW0-1", "uniprot_id": "M3K15_MOUSE", "mass": 149327.0, "length": 1331, "protein_name": "Mitogen-activated protein kinase kinase kinase 15", "gene_name": "Map3k15", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 15", "refseq_ac": "NP_001156557", "gene_names_uniprotkb": "Map3k15", "gene_names_refseq": "MEKK15; Map3k15", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 15; 2.7.11.25; MAPK/ERK kinase kinase 15; MEK kinase 15; MEKK 15", "protein_names_refseq": "MAPK/ERK kinase kinase 15; MEK kinase 15; mitogen-activated protein kinase kinase kinase 15", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (mmu:270672)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29187734", "class_list": "", "function": "Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway. Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases. May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0007254 JNK cascade;GO:0038066 p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AQW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AR95-1", "uniprot_id": "LRAD3_MOUSE", "mass": 37467.0, "length": 345, "protein_name": "Low-density lipoprotein receptor class A domain-containing protein 3", "gene_name": "Ldlrad3", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor class A domain-containing protein 3 isoform b precursor", "refseq_ac": "NP_001277713", "gene_names_uniprotkb": "Ldlrad3", "gene_names_refseq": "6430500P08; Ldlrad3; Lrad3", "protein_names_uniprotkb": "Low-density lipoprotein receptor class A domain-containing protein 3", "protein_names_refseq": "low-density lipoprotein receptor class A domain-containing protein 3 isoform b precursor; low-density lipoprotein receptor class A domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:241576)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21795536;33208938;37556325", "class_list": "", "function": "Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice., [RefSeq, PubMed]; LDLRAD3 is a receptor for Venezuelan equine encephalitis virus., [RefSeq, PubMed]; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production (PubMed:21795536). May regulate ITCH and NEDD4 E3 ligase activity and degradation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AR96;Q8CCS0;Q8CDR7", "ec_number_list": "", "go_molecular_function": "GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0070613 regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AR95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H694-1", "uniprot_id": "LRC63_MOUSE", "mass": 71730.0, "length": 638, "protein_name": "Leucine-rich repeat-containing protein 63", "gene_name": "Lrrc63", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 63", "refseq_ac": "NP_081857", "gene_names_uniprotkb": "Lrrc63", "gene_names_refseq": "4921509B22Rik; Lrrc63", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 63", "protein_names_refseq": "leucine-rich repeat-containing protein 63", "tax_id": 10090, "disease": "", "pathway": " (mmu:70859)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X8V0;Q9D5X5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H694-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54782-1", "uniprot_id": "MA2B2_MOUSE", "mass": 115610.0, "length": 1018, "protein_name": "Epididymis-specific alpha-mannosidase", "gene_name": "Man2b2", "organism": "Mouse", "refseq_name": "epididymis-specific alpha-mannosidase isoform 1 precursor", "refseq_ac": "NP_032576", "gene_names_uniprotkb": "Man2b2; Kiaa0935", "gene_names_refseq": "Man2b2; mKIAA0935", "protein_names_uniprotkb": "Epididymis-specific alpha-mannosidase; 3.2.1.24; Core-specific lysosomal alpha-1,6-Mannosidase; Epman; Mannosidase alpha class 2B member 2", "protein_names_refseq": "135 kD alpha-D-mannosidase; 135 kDa alpha-D-mannosidase; core-specific lysosomal alpha-1,6-Mannosidase; epididymis-specific alpha-mannosidase isoform 1 precursor; epididymis-specific alpha-mannosidase; epman; mannosidase alpha class 2B member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17160); (R-MMU-8853383)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;25428506;26495903;26740625;28011936;31219806;34428180;37828378;9425289", "class_list": "glycogene;glycosylhydrolase", "function": "Specifically cleaves terminal alpha 1,6-linked mannose residues on Man3GlcNAc and Man2GlcNAc core oligosaccharides generated by N-glycan degradation pathways, having little activity, if any, on larger mannose oligosaccharides. Does not cleave terminal alpha 1,6-linked mannose on Man3GlcNAc2, and is also unable to hydrolyze terminal alpha 1,3-mannose linkages., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 83, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZV1;Q8BH85;Q9DBK2", "ec_number_list": "3.2.1.24", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0008496 mannan endo-1,6-alpha-mannosidase activity;GO:0052767 mannosyl-oligosaccharide 1,6-alpha-mannosidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0006013 mannose metabolic process;GO:0009313 oligosaccharide catabolic process;GO:0006516 glycoprotein catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54782-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35900-1", "uniprot_id": "LSM2_MOUSE", "mass": 10835.0, "length": 95, "protein_name": "U6 snRNA-associated Sm-like protein LSm2", "gene_name": "Lsm2", "organism": "Mouse", "refseq_name": "U6 snRNA-associated Sm-like protein LSm2 isoform 2", "refseq_ac": "NP_001103571", "gene_names_uniprotkb": "Lsm2; G7b", "gene_names_refseq": "D17H6S56E-2; D17H6S56E2; Dmapl; Dmpkap; G7b; Lsm2; Sm-X5; SmX5; snRNP", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm2; Protein G7b; snRNP core Sm-like protein Sm-x5", "protein_names_refseq": "G7b alternative form; LSM2 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm2 isoform 2; U6 snRNA-associated Sm-like protein LSm2; dystrophia myotonica-protein kinase associated protein; small ribonuclear protein G7b; snRNP core Sm-like protein Sm-x5; snRNP core protein SMX5", "tax_id": 10090, "disease": "", "pathway": " (mmu:27756); (R-MMU-430039); (R-MMU-72163)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11797099;20173027;21750661;30084848;31219806;34428180;35820727;9271633", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0000932 P-body", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0006402 mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "H3BJG9-1", "uniprot_id": "LY6L_MOUSE", "mass": 15540.0, "length": 140, "protein_name": "Lymphocyte antigen 6L", "gene_name": "Ly6l", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6L precursor", "refseq_ac": "NP_001333978", "gene_names_uniprotkb": "Ly6l; Gm20654", "gene_names_refseq": "Gm20654; Ly6l", "protein_names_uniprotkb": "Lymphocyte antigen 6L; Lymphocyte antigen 6 complex locus protein L", "protein_names_refseq": "lymphocyte antigen 6 complex locus protein L; lymphocyte antigen 6 complex, locus L; lymphocyte antigen 6L precursor; lymphocyte antigen 6L", "tax_id": 10090, "disease": "", "pathway": " (mmu:102637705)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H3BJG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08663-1", "uniprot_id": "MAP2_MOUSE", "mass": 52922.0, "length": 478, "protein_name": "Methionine aminopeptidase 2", "gene_name": "Metap2", "organism": "Mouse", "refseq_name": "methionine aminopeptidase 2", "refseq_ac": "NP_062622", "gene_names_uniprotkb": "Metap2; Mnpep; P67eif2", "gene_names_refseq": "4930584B20Rik; A930035J23Rik; Amp2; Metap2; Mnpep; p67eIF2; p67", "protein_names_uniprotkb": "Methionine aminopeptidase 2; 3.4.11.18; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MetAP 2; Peptidase M; p67eIF2; p67", "protein_names_refseq": "MAP 2; eIF-2-associated p67; initiation factor 2-associated 67 kDa glycoprotein; initiation factor 2-associated protein (p67); metAP 2; methionine aminopeptidase 2; peptidase M 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56307); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11994292;18828628;21750661;22517741;25428506;31219806;31877115;32708166;34428180;35296207", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)., [UniProtKB, HAMAP]; Discovery, identification, and characterization of candidate pharmacodynamic markers of Metap2 inhibition are reported., [RefSeq, PubMed]; MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity. Publication Status: Online-Only, [RefSeq, PubMed]; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis., [UniProtKB, HAMAP]; The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The functional role of S100A4 in regulating endothelial cell growth and tumor metastasis involves interaction with the N-terminal half of Methionine Aminopeptidase 2., [RefSeq, PubMed]; Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.11.18;3.6.5.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006446 regulation of translational initiation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08663-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13297-1", "uniprot_id": "MSX1_MOUSE", "mass": 31672.0, "length": 303, "protein_name": "Homeobox protein MSX-1", "gene_name": "Msx1", "organism": "Mouse", "refseq_name": "homeobox protein MSX-1", "refseq_ac": "NP_034965", "gene_names_uniprotkb": "Msx1; Hox7.1; Hox7", "gene_names_refseq": "Hox-7; Hox7.1; Hox7; Msx1; msh", "protein_names_uniprotkb": "Homeobox protein MSX-1; Homeobox protein Hox-7; Hox-7.1; Msh homeobox 1-like protein", "protein_names_refseq": "homeo box, msh-like 1; homeobox protein Hox-7; homeobox protein MSX-1; homeobox, msh-like 1; hox-7.1; msh homeobox 1-like protein; muscle-segment homeobox", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); tooth agenesis (Disease Ontology:DOID:0050591); orofacial cleft 5 (Disease Ontology:DOID:0080399); anodontia (Disease Ontology:DOID:13714); tooth and nail syndrome (Disease Ontology:DOID:6678); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:17701)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10215616;11369996;11580277;16600910;16678795;1673109;1677742;1682128;22629437;23371388;24028588;2565278;2565810;27713059;29148101;33080014;7823952;7914451;8898217", "class_list": "", "function": "Acts as a transcriptional repressor (PubMed:23371388, PubMed:7823952). Capable of transcription autoinactivation (PubMed:10215616). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (PubMed:23371388). Represses transcription of myoblast differentiation factors (PubMed:16600910). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (PubMed:16600910). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (PubMed:24028588, PubMed:27713059, PubMed:29148101, PubMed:7914451, PubMed:8898217). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (PubMed:8898217). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (PubMed:27713059). Required for BMP4 expression in dental mesenchyme cells (PubMed:8898217). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (PubMed:8898217). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (PubMed:8898217). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (PubMed:8898217). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as a homeostatic regulator of the cell cycle (PubMed:24028588, PubMed:29148101). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (PubMed:24028588, PubMed:29148101). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (PubMed:7914451). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (PubMed:7914451). Required for correct formation and thickness of the nail plate (PubMed:11369996). May play a role in limb-pattern formation (PubMed:1677742)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W75;Q9ERF6", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0043584 nose development;GO:0097152 mesenchymal cell apoptotic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P13297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78PY7-1", "uniprot_id": "SND1_MOUSE", "mass": 102088.0, "length": 910, "protein_name": "Staphylococcal nuclease domain-containing protein 1", "gene_name": "Snd1", "organism": "Mouse", "refseq_name": "staphylococcal nuclease domain-containing protein 1", "refseq_ac": "NP_062750", "gene_names_uniprotkb": "Snd1", "gene_names_refseq": "Snd1; Tudor-SN", "protein_names_uniprotkb": "Staphylococcal nuclease domain-containing protein 1; 100 kDa coactivator; 3.1.31.1; p100 co-activator", "protein_names_refseq": "100 kDa coactivator; p100 co-activator; staphylococcal nuclease domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56463)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;12709443;12819296;17242355;18250455;21183079;21750661;23806337;24882364;25428506;26495903;28011936;28315936;28935714;30084848;32152506;34203471;34428180;35820727;36210013;37453647;37828378;37905668;37973913;38279051;39627609", "class_list": "", "function": "Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (PubMed:12819296)., [UniProtKB, PubMed, UniProtKB]; Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma., [RefSeq, PubMed]; P100 regulates the binding activity of RelB/p50 dimers via at least two distinct mechanisms depending on the signaling pathway involved., [RefSeq, PubMed]; SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT46;Q922L5;Q9R0S1", "ec_number_list": "", "go_molecular_function": "GO:1905172 RISC complex binding;GO:0003723 RNA binding;GO:0004519 endonuclease activity;GO:0004521 RNA endonuclease activity;GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0042470 melanosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0010564 regulation of cell cycle process;GO:0010587 miRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q78PY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17553-1", "uniprot_id": "WNT3_MOUSE", "mass": 39659.0, "length": 355, "protein_name": "Proto-oncogene Wnt-3", "gene_name": "Wnt3", "organism": "Mouse", "refseq_name": "proto-oncogene Wnt-3 precursor", "refseq_ac": "NP_033547", "gene_names_uniprotkb": "Wnt3; Int-4; Wnt-3", "gene_names_refseq": "Int-4; Wnt-3; Wnt3", "protein_names_uniprotkb": "Proto-oncogene Wnt-3; Proto-oncogene Int-4", "protein_names_refseq": "proto-oncogene Int-4; proto-oncogene Wnt-3 precursor; proto-oncogene Wnt-3; proto-oncogene protein Wnt-3; wingless-related MMTV integration site 3", "tax_id": 10090, "disease": "tetraamelia syndrome 1 (Disease Ontology:DOID:0112192)", "pathway": " (mmu:22415); (R-MMU-201681); (R-MMU-3238698)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10431240;10866835;12569130;19841259;2162045", "class_list": "glycogene", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis (PubMed:10431240). Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development (PubMed:12569130)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0019904 protein domain specific binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060323 head morphogenesis;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P17553-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22724-1", "uniprot_id": "WNT4_MOUSE", "mass": 39050.0, "length": 351, "protein_name": "Protein Wnt-4", "gene_name": "Wnt4", "organism": "Mouse", "refseq_name": "protein Wnt-4 precursor", "refseq_ac": "NP_033549", "gene_names_uniprotkb": "Wnt4; Wnt-4", "gene_names_refseq": "Wnt-4; Wnt4", "protein_names_uniprotkb": "Protein Wnt-4", "protein_names_refseq": "protein Wnt-4 precursor; protein Wnt-4; signal molecule; wingless-related MMTV integration site 4", "tax_id": 10090, "disease": "Mullerian aplasia and hyperandrogenism (Disease Ontology:DOID:0111526); endometrial carcinoma (Disease Ontology:DOID:2871); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (mmu:22417); (R-MMU-3238698); (R-MMU-4086400)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10866835;16054034;17537789;19830824;2279700;26321050;7990960;9989404", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:16054034, PubMed:17537789, PubMed:19830824, PubMed:26321050, PubMed:7990960, PubMed:9989404). Required for normal mesenchyme to epithelium transition during embryonic kidney development (PubMed:16054034, PubMed:17537789, PubMed:19830824, PubMed:7990960). Required for the formation of early epithelial renal vesicles during kidney development (PubMed:16054034). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:19830824, PubMed:9989404). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:9989404). Required for normal lung development and for normal patterning of trachael cartilage rings (PubMed:26321050)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0003714 transcription corepressor activity;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0045836 positive regulation of meiotic nuclear division;GO:0072006 nephron development;GO:0060993 kidney morphogenesis;GO:0060126 somatotropin secreting cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P22724-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PM9-1", "uniprot_id": "UCK2_MOUSE", "mass": 29404.0, "length": 261, "protein_name": "Uridine-cytidine kinase 2", "gene_name": "Uck2", "organism": "Mouse", "refseq_name": "uridine-cytidine kinase 2 isoform a", "refseq_ac": "NP_109649", "gene_names_uniprotkb": "Uck2; Umpk", "gene_names_refseq": "TSA903; UK; UMK; Uck2; Umpk", "protein_names_uniprotkb": "Uridine-cytidine kinase 2; 2.7.1.48; Cytidine monophosphokinase 2; UCK 2; Uridine monophosphokinase 2", "protein_names_refseq": "UCK 2; cytidine monophosphokinase 2; uridine monophosphate kinase 2; uridine monophosphokinase 2; uridine-cytidine kinase 2 isoform a", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:80914); (R-MMU-73614)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11306702;21750661;37953355", "class_list": "", "function": "Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor., [UniProtKB, UniProtKB]; Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral beta-d-N4-hydroxycytidine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99PM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q52KG5-1", "uniprot_id": "KI26A_MOUSE", "mass": 196313.0, "length": 1881, "protein_name": "Kinesin-like protein KIF26A", "gene_name": "Kif26a", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF26A", "refseq_ac": "NP_001091090", "gene_names_uniprotkb": "Kif26a; Kiaa1236", "gene_names_refseq": "Kif26a; mKIAA1236", "protein_names_uniprotkb": "Kinesin-like protein KIF26A", "protein_names_refseq": "N-11 kinesin; kinesin-like protein KIF26A", "tax_id": 10090, "disease": "complex cortical dysplasia with other brain malformations 11 (Disease Ontology:DOID:0061142)", "pathway": " (mmu:668303); (R-MMU-2132295); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11416179;19914172;25428506;30084848;33542431;34203471;36228617;36564622", "class_list": "", "function": "Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (PubMed:19914172). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617)., [UniProtKB, PubMed, PubMed]; Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon., [RefSeq, PubMed]; Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis., [RefSeq, PubMed]; Mice with a homozygous deletion of Kif26a developed a megacolon with enteric nerve hyperplasia. Kif26a-/- enteric neurons showed hypersensitivity for GDNF-Ret signaling, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "C9EF47;Q6PCY3;Q6ZPV4;Q99PT4", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0001560 regulation of cell growth by extracellular stimulus;GO:0021987 cerebral cortex development;GO:0009968 negative regulation of signal transduction;GO:0010975 regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q52KG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVP6-1", "uniprot_id": "PAPOB_MOUSE", "mass": 72329.0, "length": 642, "protein_name": "Poly(A) polymerase beta", "gene_name": "Papolb", "organism": "Mouse", "refseq_name": "poly(A) polymerase beta", "refseq_ac": "NP_064327", "gene_names_uniprotkb": "Papolb; Papt; Tpap", "gene_names_refseq": "PAP; Paplob; Papola-ps; Papolb; Papt; Plap-ps; Tpap", "protein_names_uniprotkb": "Poly(A) polymerase beta; 2.7.7.19; PAP-beta; Polynucleotide adenylyltransferase beta; Testis-specific poly(A) polymerase", "protein_names_refseq": "PAP-beta; poly(A) polymerase beta; polynucleotide adenylyltransferase beta; testis-specific poly(A) polymerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56522)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11087630;11150526;12471261;18325338;29109362;30779550", "class_list": "", "function": "Propose that TPAP governs germ cell morphogenesis by modulating specific transcription factors at posttranscriptional and posttranslational levels, [RefSeq, PubMed]; While PIWIL1 and YBX2 were associated with translationally inactive messenger ribonucleoproteins and translating polyribosomes, PAPOLB was present almost exclusively in the mRNA-free fractions of sucrose gradients. These results suggest that PAPOLB may regulate spermiogenesis through a pathway distinct from that mediated by chromatoid body-associated factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1R3", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006397 mRNA processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2WF71-1", "uniprot_id": "LRFN1_MOUSE", "mass": 81945.0, "length": 766, "protein_name": "Leucine-rich repeat and fibronectin type III domain-containing protein 1", "gene_name": "Lrfn1", "organism": "Mouse", "refseq_name": "leucine-rich repeat and fibronectin type III domain-containing protein 1 isoform 1 precursor", "refseq_ac": "NP_001135393", "gene_names_uniprotkb": "Lrfn1; Salm2; Semo1", "gene_names_refseq": "Lrfn1; SALM2; Semo1", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type III domain-containing protein 1; Synaptic adhesion-like molecule 2; Synaptic differentiation-enhancing molecule 1", "protein_names_refseq": "leucine-rich repeat and fibronectin type III domain-containing protein 1 isoform 1 precursor; leucine-rich repeat and fibronectin type III domain-containing protein 1; synaptic adhesion-like molecule 2; synaptic differentiation enhancing molecule 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:80749); (R-MMU-8849932)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16495444;16630835;16828986;18227064;18585462;21750661;33300544;34203471", "class_list": "", "function": "Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth., [RefSeq, PubMed]; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q460M4;Q8C1V9;Q99KT6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0098839 postsynaptic density membrane;GO:0016020 membrane", "go_biological_process": "GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q2WF71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35685-1", "uniprot_id": "NUDC_MOUSE", "mass": 38358.0, "length": 332, "protein_name": "Nuclear migration protein nudC", "gene_name": "Nudc", "organism": "Mouse", "refseq_name": "nuclear migration protein nudC", "refseq_ac": "NP_035078", "gene_names_uniprotkb": "Nudc", "gene_names_refseq": "Nudc; SIG-92; Silg92", "protein_names_uniprotkb": "Nuclear migration protein nudC; Nuclear distribution protein C homolog; SIG-92; Silica-induced gene 92 protein", "protein_names_refseq": "nuclear distribution gene C homolog; nuclear distribution protein C homolog; nuclear migration protein nudC; silica-induced gene 92 protein", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:18221); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025); (R-MMU-9696270)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "11734602;25428506;30084848;34428180;37828378;38441532;7868905;9601647", "class_list": "", "function": "NUDC is critical for rod photoreceptor function, maintenance, and survival., [RefSeq, PubMed]; Plays a role in neurogenesis and neuronal migration (PubMed:11734602). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). Necessary for cytokinesis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJS7", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0006457 protein folding;GO:0007080 mitotic metaphase chromosome alignment;GO:0043434 response to peptide hormone;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60764-1", "uniprot_id": "RAC3_MOUSE", "mass": 21379.0, "length": 192, "protein_name": "Ras-related C3 botulinum toxin substrate 3", "gene_name": "Rac3", "organism": "Mouse", "refseq_name": "ras-related C3 botulinum toxin substrate 3", "refseq_ac": "NP_573486", "gene_names_uniprotkb": "Rac3", "gene_names_refseq": "Rac1B; Rac3", "protein_names_uniprotkb": "Ras-related C3 botulinum toxin substrate 3; 3.6.5.2; p21-Rac3", "protein_names_refseq": "RAS-related C3 botulinum substrate 3; p21-Rac3; ras-related C3 botulinum toxin substrate 3", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 48 (Disease Ontology:DOID:0080235); alcohol use disorder (Disease Ontology:DOID:1574); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:170758); (R-MMU-4086400); (R-MMU-9013423)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14622142;15964829;15964830;21750661;33300544;36744839;37204479", "class_list": "", "function": "Data implicate Rac3 in neuronal differentiation, and support a specific role of this GTPase in actin-mediated remodelling of Purkinje cell neuritic terminals at time of synaptogenesis, [RefSeq, PubMed]; Dispensable role of Rac1 and Rac3 after cochlear hair cell specification., [RefSeq, PubMed]; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner., [UniProtKB, UniProtKB]; Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons., [RefSeq, PubMed]; The generation and characterization of Rac3 knockout mice are described., [RefSeq, PubMed]; The role of Rac3 was studied in Bcr-Abl-caused lymphoblastic leukemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O14658", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;2.7.11.1;3.6.5.4;3.6.5.5;3.6.1.-;2.7.10.1;3.6.1.15;1.3.1.70;2.7.10.2;1.6.3.-;3.1.3.86;3.1.3.56;3.1.3.36;3.6.-.-;2.3.1.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0048306 calcium-dependent protein binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030426 growth cone", "go_biological_process": "GO:0021894 cerebral cortex GABAergic interneuron development;GO:0007015 actin filament organization;GO:0031175 neuron projection development;GO:0032956 regulation of actin cytoskeleton organization;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P60764-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A028-1", "uniprot_id": "SWP70_MOUSE", "mass": 68996.0, "length": 585, "protein_name": "Switch-associated protein 70", "gene_name": "Swap70", "organism": "Mouse", "refseq_name": "switch-associated protein 70 isoform 1", "refseq_ac": "NP_033328", "gene_names_uniprotkb": "Swap70; Kiaa0640", "gene_names_refseq": "70kDa; Swap70", "protein_names_uniprotkb": "Switch-associated protein 70; SWAP-70", "protein_names_refseq": "SWAP complex protein, 70 kDa; SWAP-70; switch-associated protein 70 isoform 1; switch-associated protein 70", "tax_id": 10090, "disease": "", "pathway": " (mmu:20947); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10382743;11500831;11920580;25428506;34428180;36974751;38760173;9642267", "class_list": "", "function": "In mast cells SWAP-70 plays a role both in establishing the initial competence to degranulate and to develop into mature mast cells., [RefSeq, PubMed]; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)., [UniProtKB]; SWAP-70 deficient mice exhibit B cell anomalies including increased autoantibody production and impaired isotype switching., [RefSeq, PubMed]; SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner., [RefSeq, PubMed]; The F-actin bundler SWAP-70 promotes tumor metastasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88443;Q3TQR6;Q3UCA3;Q6P1D0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0032233 positive regulation of actin filament bundle assembly;GO:0008064 regulation of actin polymerization or depolymerization;GO:0033633 negative regulation of cell-cell adhesion mediated by integrin;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6A028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXK9-1", "uniprot_id": "SH22A_MOUSE", "mass": 40953.0, "length": 374, "protein_name": "SH2 domain-containing protein 2A", "gene_name": "Sh2d2a", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 2A isoform 1", "refseq_ac": "NP_067284", "gene_names_uniprotkb": "Sh2d2a; Lad; Ribp", "gene_names_refseq": "Lad; Ribp; Sh2d2a; Tsad", "protein_names_uniprotkb": "SH2 domain-containing protein 2A; Lad; Lck-associated adapter protein; Ribp; Rlk/Itk-binding protein", "protein_names_refseq": "Lck-associated adapter protein; Rlk/Itk-binding protein; SH2 domain protein 2A; SH2 domain-containing protein 2A isoform 1; SH2 domain-containing protein 2A; T cell-specific adapter protein; p56Lck-associated adapter protein", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676)", "pathway": " (mmu:27371); (R-MMU-4420097)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10553045;10587356;12953096;15752554;25605945;27436360;30190583;31541025;33046503", "class_list": "", "function": "Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in p56-LCK-mediated T-cell signaling. Could be involved in the regulation of responses to T-cell activation stimuli, specifically proliferation and lymphokine production. Interactions with ITK and TXK may provide important biochemical links of these two important kinases with other components in the T-cell activation machinery., [UniProtKB, PubMed]; Data suggest that TSAd modulates differentiation of experienced T cells possibly through polarization of CD4+ T cells towards the APC. Publication Status: Online-Only, [RefSeq, PubMed]; Role of TSAd as a critical regulator of T cell death whose absence promotes systemic autoimmunity, [RefSeq, PubMed]; TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response., [RefSeq, PubMed]; TSAd appears to contribute to interleukin-2 synthesis at multiple different levels Review article, [RefSeq, PubMed]; The TSAd serves as a critical cell-intrinsic molecule in CD4(+)Foxp3(+) Tregs to regulate the translocation of Lck to mitochondria, cellular activation responses, and the development of immunoregulation following solid organ transplantation., [RefSeq, PubMed]; These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHP6", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QXK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02858-1", "uniprot_id": "TIE2_MOUSE", "mass": 125701.0, "length": 1122, "protein_name": "Angiopoietin-1 receptor", "gene_name": "Tek", "organism": "Mouse", "refseq_name": "angiopoietin-1 receptor isoform 2 precursor", "refseq_ac": "NP_001277478", "gene_names_uniprotkb": "Tek; Hyk; Tie-2; Tie2", "gene_names_refseq": "Cd202b; Hyk; STK1; Tek; Tie-2; Tie2", "protein_names_uniprotkb": "Angiopoietin-1 receptor; 2.7.10.1; Endothelial tyrosine kinase; HYK; STK1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; mTIE2; p140 TEK", "protein_names_refseq": "angiopoietin-1 receptor isoform 2 precursor; angiopoietin-1 receptor; endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; p140 TEK; tunica interna endothelial cell kinase; tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protein kinase receptor TEK; tyrosine-protein kinase receptor TIE-2", "tax_id": 10090, "disease": "multiple cutaneous and mucosal venous malformations (Disease Ontology:DOID:0050792); gastric ulcer (Disease Ontology:DOID:10808); arteriovenous malformation (Disease Ontology:DOID:11294); goiter (Disease Ontology:DOID:12176); acute kidney tubular necrosis (Disease Ontology:DOID:12556); brain ischemia (Disease Ontology:DOID:2316); coronary artery disease (Disease Ontology:DOID:3393); renal Wilms' tumor (Disease Ontology:DOID:5176); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:21687); (R-MMU-210993); (R-MMU-5673001)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10521483;10557082;11375937;12082108;12427764;12665569;1282811;15284220;1630810;18299400;19451274;20973951;21750661;27270174;28179430;30084848;30899004;34428180;7596437;7958865;8187650;8217221;8386827;8395828;8415706;9632797", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for postnatal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 11, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.1;3.2.1.31;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;3.6.5.2;2.7.11.17;3.1.3.48;3.1.27.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q02858-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01728-1", "uniprot_id": "LV2A_MOUSE", "mass": 12222.0, "length": 117, "protein_name": "Immunoglobulin lambda variable 2", "gene_name": "Iglv2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Iglv2", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin lambda variable 2; Ig lambda-2 chain V region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;418414", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P01728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05533-1", "uniprot_id": "LY6A_MOUSE", "mass": 14377.0, "length": 134, "protein_name": "Lymphocyte antigen 6A-2/6E-1", "gene_name": "Ly6a", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6A-2/6E-1 precursor", "refseq_ac": "NP_001258345", "gene_names_uniprotkb": "Ly6a; Ly6", "gene_names_refseq": "Ly-6A.2; Ly-6A/E; Ly-6E.1; Ly6a; Sca-1; Sca1; TAP", "protein_names_uniprotkb": "Lymphocyte antigen 6A-2/6E-1; Ly-6A.2/Ly-6E.1; SCA-1; Stem cell antigen 1; T-cell-activating protein; TAP", "protein_names_refseq": "T-cell-activating protein; lymphocyte antigen 6 complex, locus A; lymphocyte antigen 6A-2/6E-1 precursor; lymphocyte antigen 6A-2/6E-1; stem cell antigen 1", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (mmu:110454)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1315719;15930324;1697928;1709198;21750661;2660142;2822573;2895473;3028776;3033645;34428180", "class_list": "", "function": "T-cell activation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPD0", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P05533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TX51-1", "uniprot_id": "LRC28_MOUSE", "mass": 41735.0, "length": 367, "protein_name": "Leucine-rich repeat-containing protein 28", "gene_name": "Lrrc28", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 28 isoform 1", "refseq_ac": "NP_780333", "gene_names_uniprotkb": "Lrrc28", "gene_names_refseq": "1300004K21Rik; 2210012C09Rik; 2310058O11Rik; Lrrc28", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 28", "protein_names_refseq": "leucine-rich repeat-containing protein 28 isoform 1; leucine-rich repeat-containing protein 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:67867)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGR7;Q8BK43", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016605 PML body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TX51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49138-1", "uniprot_id": "MAPK2_MOUSE", "mass": 44050.0, "length": 386, "protein_name": "MAP kinase-activated protein kinase 2", "gene_name": "Mapkapk2", "organism": "Mouse", "refseq_name": "MAP kinase-activated protein kinase 2", "refseq_ac": "NP_032577", "gene_names_uniprotkb": "Mapkapk2; Rps6kc1", "gene_names_refseq": "MAPKAP-K2; MK-2; MK2; Mapkapk2; Rps6kc1", "protein_names_uniprotkb": "MAP kinase-activated protein kinase 2; 2.7.11.1; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2", "protein_names_refseq": "MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17164); (R-MMU-171007); (R-MMU-199920); (R-MMU-2142691); (R-MMU-2559580); (R-MMU-3371453); (R-MMU-4420097); (R-MMU-450302); (R-MMU-450385); (R-MMU-450513); (R-MMU-5357905)", "pathway_count": 11, "publication_count": 20, "publication_id_list": "10559880;12052889;12456657;14688255;15850461;17030606;17242355;17906627;20724476;21323643;21750661;26495903;26740625;28935714;31599954;34428180;7592979;8093612;8262198;9628873", "class_list": "", "function": "Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (By similarity). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress following ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (By similarity). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P561", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.3.2.27;2.7.1.153;2.7.1.137;1.13.11.-;1.13.11.34;2.7.1.40;2.7.11.21;3.6.4.-;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P49138-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51949-1", "uniprot_id": "MAT1_MOUSE", "mass": 35848.0, "length": 309, "protein_name": "CDK-activating kinase assembly factor MAT1", "gene_name": "Mnat1", "organism": "Mouse", "refseq_name": "CDK-activating kinase assembly factor MAT1", "refseq_ac": "NP_032638", "gene_names_uniprotkb": "Mnat1; Mat1", "gene_names_refseq": "E130115E11Rik; MAT1; Mnat1; P36", "protein_names_uniprotkb": "CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; Menage a trois; RING finger protein MAT1; p35; p36", "protein_names_refseq": "CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; RING finger protein MAT1; p35", "tax_id": 10090, "disease": "", "pathway": " (mmu:17420); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-69200); (R-MMU-69202); (R-MMU-69231); (R-MMU-69273); (R-MMU-69656); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-8939236)", "pathway_count": 25, "publication_count": 11, "publication_id_list": "17276355;20231280;21183079;21385826;21750661;21952136;31219806;31421084;34428180;40997131;7553872", "class_list": "", "function": "Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (By similarity). Binds and activates CDK7, the catalytic subunit of CAK (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in cell cycle control and in RNA transcription by RNA polymerase II (By similarity)., [UniProtKB, UniProtKB]; Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation., [RefSeq, PubMed]; Investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells, [RefSeq, PubMed]; MAT1 serves as a promoter in the lung metastasis of osteosarcoma through increasing AKT1 expression., [RefSeq, PubMed]; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II., [UniProtKB, UniProtKB, UniProtKB]; This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BS9;Q3TZP0;Q9D8A0;Q9D8D2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0070985 transcription factor TFIIK complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P51949-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61969-1", "uniprot_id": "LMO4_MOUSE", "mass": 17994.0, "length": 165, "protein_name": "LIM domain transcription factor LMO4", "gene_name": "Lmo4", "organism": "Mouse", "refseq_name": "LIM domain transcription factor LMO4", "refseq_ac": "NP_001155241", "gene_names_uniprotkb": "Lmo4", "gene_names_refseq": "A730077C12Rik; Crp3; Etohi4; Lmo4", "protein_names_uniprotkb": "LIM domain transcription factor LMO4; Breast tumor autoantigen; LIM domain only protein 4; LMO-4", "protein_names_refseq": "LIM domain only protein 4; LIM domain transcription factor LMO4; LMO-4; breast tumor autoantigen; ethanol induced 4", "tax_id": 10090, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (mmu:16911)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11751867;12727888;15343268;17001033;18539116;21750661;22723967;23353824;37552690;9736723;9840944;9860983", "class_list": "", "function": "Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription cofactor (PubMed:18539116). Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons (PubMed:18539116)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O00158;O88894", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031252 cell leading edge;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0E1-1", "uniprot_id": "M1AP_MOUSE", "mass": 58618.0, "length": 529, "protein_name": "Meiosis 1 arrest protein", "gene_name": "M1ap", "organism": "Mouse", "refseq_name": "meiosis 1 arrest protein", "refseq_ac": "NP_149070", "gene_names_uniprotkb": "M1ap; D6Mm5e; Spata37", "gene_names_refseq": "D6Mm5e; M1ap", "protein_names_uniprotkb": "Meiosis 1 arrest protein; Meiosis 1-arresting protein; Meiosis 1-associated protein; Spermatogenesis-associated protein 37", "protein_names_refseq": "meiosis 1 arrest protein; meiosis 1-arresting protein; spermatogenesis-associated protein 37", "tax_id": 10090, "disease": "spermatogenic failure 48 (Disease Ontology:DOID:0112176)", "pathway": " (mmu:110958)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15044690;16881047;21183079;21750661;23269666;32673564;34428180;9927484", "class_list": "", "function": "Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility., [RefSeq, PubMed]; D6Mm5e is expressed in the germ cells of the female embryo upon their initial entry into meiosis, and in male germ cells during the last stages of spermatogenesis., [RefSeq, PubMed]; Deficiency in M1ap results in a wide range of tubular defects, which led to severe oligozoospermia and infertility. Publication Status: Online-Only, [RefSeq, PubMed]; Required for meiosis I progression during spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2A0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006396 RNA processing;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006325 chromatin organization;GO:0007292 female gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z0E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2R5-1", "uniprot_id": "LRC61_MOUSE", "mass": 27964.0, "length": 259, "protein_name": "Leucine-rich repeat-containing protein 61", "gene_name": "Lrrc61", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 61", "refseq_ac": "NP_001103630", "gene_names_uniprotkb": "Lrrc61", "gene_names_refseq": "Lrrc61", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 61", "protein_names_refseq": "leucine-rich repeat-containing protein 61", "tax_id": 10090, "disease": "", "pathway": " (mmu:243371)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22872234;31219806;34203471;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB45;Q3UPT0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R2R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08731-1", "uniprot_id": "LIT2_MOUSE", "mass": 19407.0, "length": 173, "protein_name": "Lithostathine-2", "gene_name": "Reg2", "organism": "Mouse", "refseq_name": "lithostathine-2 precursor", "refseq_ac": "NP_033069", "gene_names_uniprotkb": "Reg2", "gene_names_refseq": "PSP; PTP; REG-2; Reg2", "protein_names_uniprotkb": "Lithostathine-2; Islet of Langerhans regenerating protein 2; PSP; PTP; Pancreatic stone protein 2; Pancreatic thread protein 2; REG-2", "protein_names_refseq": "islet of Langerhans regenerating protein 2; lithostathine-2 precursor; lithostathine-2; pancreatic stone protein 2; pancreatic thread protein 2; regenerating islet-derived, mouse homolog 2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Sjogren's syndrome (Disease Ontology:DOID:12894); cholangiocarcinoma (Disease Ontology:DOID:4947); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:19693)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;36063729;8340418", "class_list": "glycogene", "function": "Might act as an inhibitor of spontaneous calcium carbonate precipitation., [UniProtKB]; Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001967 suckling behavior;GO:0008284 positive regulation of cell population proliferation;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0042552 myelination;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2I4-1", "uniprot_id": "MANBA_MOUSE", "mass": 100831.0, "length": 879, "protein_name": "Beta-mannosidase", "gene_name": "Manba", "organism": "Mouse", "refseq_name": "beta-mannosidase precursor", "refseq_ac": "NP_081564", "gene_names_uniprotkb": "Manba; Bmn", "gene_names_refseq": "2410030O07Rik; B930014J03Rik; Bmn; Manba", "protein_names_uniprotkb": "Beta-mannosidase; 3.2.1.25; Lysosomal beta A mannosidase; Mannanase; Mannase", "protein_names_refseq": "beta-mannosidase precursor; beta-mannosidase; lysosomal beta A mannosidase; mannanase; mannase", "tax_id": 10090, "disease": "beta-mannosidosis (Disease Ontology:DOID:3633)", "pathway": " (mmu:110173); (R-MMU-6798695); (R-MMU-8853383)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11892998;16377659;21750661;26740625;30552791;30899004;31219806;34428180;40997131", "class_list": "glycogene;glycosylhydrolase", "function": "Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 65, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDB3;Q3TLS7;Q3UQT5;Q99MS1;Q9CRH3", "ec_number_list": "2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.6.5.2;3.4.23.-;3.2.1.20;7.6.2.1;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;7.6.2.-;3.4.16.2;3.1.3.5;3.1.3.2;3.1.3.48;3.2.1.25;2.5.1.18;3.5.1.92", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0005537 D-mannose binding;GO:0004567 beta-mannosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8K2I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDB8-1", "uniprot_id": "LRRC2_MOUSE", "mass": 42956.0, "length": 371, "protein_name": "Leucine-rich repeat-containing protein 2", "gene_name": "Lrrc2", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 2", "refseq_ac": "NP_083114", "gene_names_uniprotkb": "Lrrc2", "gene_names_refseq": "2400002D05Rik; 4933431K03Rik; Lrrc2", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 2", "protein_names_refseq": "leucine-rich repeat-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74249)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12461651;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CX04", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VDB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D009-1", "uniprot_id": "LIPT2_MOUSE", "mass": 24955.0, "length": 231, "protein_name": "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial", "gene_name": "Lipt2", "organism": "Mouse", "refseq_name": "octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial", "refseq_ac": "NP_080286", "gene_names_uniprotkb": "Lipt2", "gene_names_refseq": "2610209A20Rik; Lipt2", "protein_names_uniprotkb": "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial; 2.3.1.181; Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Lipoyltransferase 2", "protein_names_refseq": "lipoate-protein ligase B; lipoyl/octanoyl transferase; octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase; octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial; putative lipoyltransferase 2, mitochondrial; putative octanoyltransferase, mitochondrial", "tax_id": 10090, "disease": "dystonia (Disease Ontology:DOID:543); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (mmu:67164); (R-MMU-9857492)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;23806337;29987032;31219806", "class_list": "", "function": "Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes such as the protein H of the glycine cleavage system (GCSH) (PubMed:29987032). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14C29;Q9CVA5", "ec_number_list": "2.3.1.181", "go_molecular_function": "GO:0016874 ligase activity;GO:0033819 lipoyl(octanoyl) transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPD7-1", "uniprot_id": "LR75B_MOUSE", "mass": 34160.0, "length": 306, "protein_name": "Leucine-rich repeat-containing protein 75B", "gene_name": "Lrrc75b", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 75B", "refseq_ac": "NP_942560", "gene_names_uniprotkb": "Lrrc75b; Fam211b", "gene_names_refseq": "Fam211b; Lrrc75b", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 75B; Leucine-rich repeat-containing protein FAM211B", "protein_names_refseq": "family with sequence similarity 211, member B; leucine-rich repeat-containing protein 75B; leucine-rich repeat-containing protein C22orf36 homolog; leucine-rich repeat-containing protein FAM211B", "tax_id": 10090, "disease": "", "pathway": " (mmu:192734)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27633041", "class_list": "", "function": "Data show that leucine rich repeat containing 75B (Lrrc75b) is a suppressor of C2C12 myoblast myogenic differentiation., [RefSeq, PubMed]; May suppress myogenic differentiation by modulating MYOG expression and Erk1/2 signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1Q4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TPD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIM1-1", "uniprot_id": "LRC45_MOUSE", "mass": 76384.0, "length": 670, "protein_name": "Leucine-rich repeat-containing protein 45", "gene_name": "Lrrc45", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 45", "refseq_ac": "NP_705773", "gene_names_uniprotkb": "Lrrc45", "gene_names_refseq": "Lrrc45", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 45", "protein_names_refseq": "leucine-rich repeat-containing protein 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:217366)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AC12;Q3U5Z2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0120329 protein localization to centriolar satellite", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CIM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXH2-1", "uniprot_id": "MANEA_MOUSE", "mass": 53183.0, "length": 462, "protein_name": "Glycoprotein endo-alpha-1,2-mannosidase", "gene_name": "Manea", "organism": "Mouse", "refseq_name": "glycoprotein endo-alpha-1,2-mannosidase isoform 1", "refseq_ac": "NP_766453", "gene_names_uniprotkb": "Manea", "gene_names_refseq": "4932703L02Rik; Manea", "protein_names_uniprotkb": "Glycoprotein endo-alpha-1,2-mannosidase; 3.2.1.130; Endo-alpha mannosidase; Endomannosidase; mEndo", "protein_names_refseq": "endo-alpha mannosidase; endomannosidase; glycoprotein endo-alpha-1,2-mannosidase isoform 1; glycoprotein endo-alpha-1,2-mannosidase; mEndo", "tax_id": 10090, "disease": "anxiety disorder (Disease Ontology:DOID:2030); panic disorder (Disease Ontology:DOID:594); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:242362); (R-MMU-964739)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;30084848;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0N9", "ec_number_list": "3.2.1.130", "go_molecular_function": "GO:0004559 alpha-mannosidase activity;GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NXH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1G5-1", "uniprot_id": "LRC57_MOUSE", "mass": 26760.0, "length": 239, "protein_name": "Leucine-rich repeat-containing protein 57", "gene_name": "Lrrc57", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lrrc57", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 57", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC95", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D1G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVP6-1", "uniprot_id": "LYPD4_MOUSE", "mass": 26996.0, "length": 246, "protein_name": "Ly6/PLAUR domain-containing protein 4", "gene_name": "Lypd4", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 4 precursor", "refseq_ac": "NP_877586", "gene_names_uniprotkb": "Lypd4", "gene_names_refseq": "4933400F01Rik; Lypd4", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 4", "protein_names_refseq": "ly6/PLAUR domain-containing protein 4 precursor; ly6/PLAUR domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:232973); (R-MMU-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;32040177", "class_list": "", "function": "LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertilitydagger., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0044853 plasma membrane raft;GO:0001669 acrosomal vesicle;GO:0098552 side of membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0160131 sperm migration through the uterotubal junction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BVP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWV0-1", "uniprot_id": "MASU1_MOUSE", "mass": 26020.0, "length": 228, "protein_name": "Mitochondrial assembly of ribosomal large subunit protein 1", "gene_name": "Malsu1", "organism": "Mouse", "refseq_name": "mitochondrial assembly of ribosomal large subunit protein 1", "refseq_ac": "NP_083629", "gene_names_uniprotkb": "Malsu1; 2410003K15Rik", "gene_names_refseq": "2410003K15Rik; Malsu1; Matsu1", "protein_names_uniprotkb": "Mitochondrial assembly of ribosomal large subunit protein 1", "protein_names_refseq": "mitochondrial assembly of ribosomal large subunit protein 1; protein C7orf30 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75593); (R-MMU-9937383)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043023 ribosomal large subunit binding;GO:0140978 mitochondrial large ribosomal subunit binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0017148 negative regulation of translation;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0070130 negative regulation of mitochondrial translation;GO:0090071 negative regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YS5-1", "uniprot_id": "LRC27_MOUSE", "mass": 59853.0, "length": 523, "protein_name": "Leucine-rich repeat-containing protein 27", "gene_name": "Lrrc27", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 27 isoform a", "refseq_ac": "NP_081440", "gene_names_uniprotkb": "Lrrc27", "gene_names_refseq": "1700071K18Rik; 2310044E02Rik; Lrrc27", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 27", "protein_names_refseq": "leucine-rich repeat-containing protein 27 isoform a; leucine-rich repeat-containing protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:76612)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6Z2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80YS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPX3-1", "uniprot_id": "LYZL1_MOUSE", "mass": 16802.0, "length": 148, "protein_name": "Lysozyme-like protein 1", "gene_name": "Lyzl1", "organism": "Mouse", "refseq_name": "lysozyme-like protein 1 isoform 1 precursor", "refseq_ac": "NP_080368", "gene_names_uniprotkb": "Lyzl1; Lyc2", "gene_names_refseq": "1700038F02Rik; Lyc2; Lyzd1; Lyzl1", "protein_names_uniprotkb": "Lysozyme-like protein 1; 3.2.1.17", "protein_names_refseq": "lysozyme d1; lysozyme-like protein 1 isoform 1 precursor; lysozyme-like protein 1; lysozyme-like protein 2", "tax_id": 10090, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:67328)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CPX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K377-1", "uniprot_id": "LRRT1_MOUSE", "mass": 58718.0, "length": 522, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 1", "gene_name": "Lrrtm1", "organism": "Mouse", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 1 precursor", "refseq_ac": "NP_083156", "gene_names_uniprotkb": "Lrrtm1", "gene_names_refseq": "4632401D06Rik; Lrrtm1", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 1", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 1 precursor; leucine-rich repeat transmembrane neuronal protein 1", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:74342); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12676565;16860615;17667961;19285470;21750661;33300544;34203471;35662394;36709330", "class_list": "", "function": "Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions. Publication Status: Online-Only, [RefSeq, PubMed]; Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits. Publication Status: Online-Only, [RefSeq, PubMed]; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVX1", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007626 locomotory behavior;GO:0050808 synapse organization;GO:0035640 exploration behavior;GO:0051965 positive regulation of synapse assembly;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8K377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZP0-1", "uniprot_id": "MALD2_MOUSE", "mass": 63662.0, "length": 555, "protein_name": "MARVEL domain-containing protein 2", "gene_name": "Marveld2", "organism": "Mouse", "refseq_name": "MARVEL domain-containing protein 2 isoform 1", "refseq_ac": "NP_001033691", "gene_names_uniprotkb": "Marveld2; Mrvldc2; Tric", "gene_names_refseq": "MARVD2; Marveld2; Mrvldc2; Trica; Tricb; Tricc; Tric", "protein_names_uniprotkb": "MARVEL domain-containing protein 2; Tricellulin", "protein_names_refseq": "MARVEL domain-containing protein 2 isoform 1; MARVEL domain-containing protein 2; tricellulin", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 49 (Disease Ontology:DOID:0110506)", "pathway": " (mmu:218518)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "16365161;17186462;18768749;20164257;21097846;21183079;21245199;21750661;23239027;24889144;25217574;26677943;35820727;37569268", "class_list": "", "function": "In the inner ear, tricellulin is concentrated at the tricellular tight-junctions in cochlear and vestibular epithelia, including the structurally complex and extensive junctions between supporting and hair cells., [RefSeq, PubMed]; In this study, we identify tricellulin, the first integral membrane protein that is concentrated at the vertically oriented TJ strands of tricellular contacts., [RefSeq, PubMed]; Knockdown of occludin caused mislocalization of tricellulin to bTJs, implying that occludin supports tricellular localization of tricellulin by excluding tricellulin from bicellular tight junctions., [RefSeq, PubMed]; MarvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family, [RefSeq, PubMed]; Plays a role in the formation of tricellular tight junctions and of epithelial barriers (PubMed:16365161, PubMed:21245199). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:26677943)., [UniProtKB, PubMed, PubMed, PubMed]; The tricellulin may be a component to maintain the integrity for PNS myelin function and morphology., [RefSeq, PubMed]; Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UJ4;Q99LE8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0007605 sensory perception of sound;GO:0070830 bicellular tight junction assembly;GO:0045216 cell-cell junction organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UZP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4C1-1", "uniprot_id": "LMTD1_MOUSE", "mass": 45937.0, "length": 413, "protein_name": "Lamin tail domain-containing protein 1", "gene_name": "Lmntd1", "organism": "Mouse", "refseq_name": "lamin tail domain-containing protein 1 isoform a", "refseq_ac": "NP_083018", "gene_names_uniprotkb": "Lmntd1; Ifltd1; Lmna-rs1", "gene_names_refseq": "4933403M22Rik; Ifltd1; Lmna-rs1; Lmna1; Lmntd1", "protein_names_uniprotkb": "Lamin tail domain-containing protein 1; Intermediate filament tail domain-containing protein 1; Lamin-A-related sequence 1 protein", "protein_names_refseq": "intermediate filament tail domain containing 1; intermediate filament tail domain-containing protein 1; lamin A-related sequence 1; lamin tail domain-containing protein 1 isoform a; lamin tail domain-containing protein 1; lamin-A-related sequence 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74071)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15064703;15688036;21750661", "class_list": "", "function": "Lmna-rs1 is part of the complex multigenic Pas1 locus. It may be a tumor suppressor. AA changes and downregulation are associated with lung adenoma susceptibility., [RefSeq, PubMed]; Pas1c1(lmna-rs1) is a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation in lung adenoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5UE52", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005882 intermediate filament", "go_biological_process": "GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D4C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4U7-1", "uniprot_id": "LUZP1_MOUSE", "mass": 119311.0, "length": 1068, "protein_name": "Leucine zipper protein 1", "gene_name": "Luzp1", "organism": "Mouse", "refseq_name": "leucine zipper protein 1", "refseq_ac": "NP_077772", "gene_names_uniprotkb": "Luzp1; Luzp", "gene_names_refseq": "2700072H04Rik; Luzp1; Luzp; mFLJ00226", "protein_names_uniprotkb": "Leucine zipper protein 1; Filamin mechanobinding actin cross-linking protein; Fimbacin; Leucine zipper motif-containing protein", "protein_names_refseq": "filamin mechanobinding actin cross-linking protein; fimbacin; leucine zipper motif-containing protein; leucine zipper protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269593)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11702014;16452087;17242355;18801334;19131326;19144319;21183079;21750661;22645316;26192747;28528544;32553112;32848054;33346378;33869174;34197713;34428180;34887587;36852467;37806546;40021952;40885482;8812416", "class_list": "", "function": "A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction., [RefSeq, PubMed]; Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1., [RefSeq, PubMed]; F-actin cross-linking protein (By similarity). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32553112). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (By similarity). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (By similarity). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (PubMed:33346378). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (PubMed:33869174). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (PubMed:34197713). Plays a role in embryonic brain and cardiovascular development (PubMed:18801334)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A3KG96;Q3UV18;Q7TS71;Q8BQW1;Q99NG3;Q9CSL6", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005884 actin filament;GO:0005923 bicellular tight junction", "go_biological_process": "GO:1903119 protein localization to actin cytoskeleton;GO:1902018 negative regulation of cilium assembly;GO:0060840 artery development;GO:0003281 ventricular septum development;GO:0043149 stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q8R4U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFF7-1", "uniprot_id": "LYPL1_MOUSE", "mass": 26354.0, "length": 239, "protein_name": "Lysophospholipase-like protein 1", "gene_name": "Lyplal1", "organism": "Mouse", "refseq_name": "lysophospholipase-like protein 1", "refseq_ac": "NP_666218", "gene_names_uniprotkb": "Lyplal1", "gene_names_refseq": "Lyplal1; Q96AVO", "protein_names_uniprotkb": "Lysophospholipase-like protein 1; 3.1.2.22", "protein_names_refseq": "lysophospholipase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226791)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25958046;36748836", "class_list": "", "function": "Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity. Publication Status: Online-Only, [RefSeq, PubMed]; Lyplal1 mRNA was up-regulated during adipogenesis and enriched in mature adipocytes through a PPARgamma-independent mechanism. overexpression and knockdown of Lyplal1 did not perturb adipogenesis, triacylglycerol accumulation and/or insulin signaling., [RefSeq, PubMed]; Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1. Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R065", "ec_number_list": "3.1.2.22;3.1.2.2;3.1.2.-;2.3.1.-;3.1.1.93;3.4.-.-;3.4.19.12", "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042997 negative regulation of Golgi to plasma membrane protein transport;GO:0002084 protein depalmitoylation;GO:0160049 negative regulation of cGAS/STING signaling pathway;GO:0140896 cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UFF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70699-1", "uniprot_id": "LYAG_MOUSE", "mass": 106248.0, "length": 953, "protein_name": "Lysosomal alpha-glucosidase", "gene_name": "Gaa", "organism": "Mouse", "refseq_name": "lysosomal alpha-glucosidase preproprotein", "refseq_ac": "NP_001152796", "gene_names_uniprotkb": "Gaa", "gene_names_refseq": "E430018M07Rik; Gaa", "protein_names_uniprotkb": "Lysosomal alpha-glucosidase; 3.2.1.20; Acid maltase", "protein_names_refseq": "acid maltase; lysosomal alpha-glucosidase preproprotein; lysosomal alpha-glucosidase", "tax_id": 10090, "disease": "glycogen storage disease II (Disease Ontology:DOID:2752)", "pathway": " (mmu:14387); (R-MMU-6798695); (R-MMU-70221)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;19349973;20173027;21750661;25428506;26495903;26740625;28011936;30084848;30899004;31219806;32152506;33300544;34428180;35820727;35984892;37828378;40021952;40885482", "class_list": "glycogene;glycosylhydrolase", "function": "Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans., [UniProtKB, UniProtKB]; This gene encodes a lysosomal acid glucosidase that is involved in the degradation of glycogen. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that cleaves alpha-1-4 and alpha-1-6 glycosidic bonds of glycogen, maltose and intermediate oligosaccharides within the lysosome. Mice lacking the encoded protein exhibit symptoms similar to human Pompe syndrome such as accumulation of glycogen in cardiac and skeletal muscle lysosomes resulting in reduced mobility and strength. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 65, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJB2;Q8BGI6;Q91Z45", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;3.4.24.81;3.4.21.73;3.6.5.2;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.4.23.-;1.1.1.-;3.2.1.20;3.1.3.-;3.4.24.-;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.78;7.6.2.-;1.6.3.-;3.4.16.2;3.6.1.29;3.1.3.5;3.1.3.2;3.2.1.25;2.5.1.18;3.6.1.-;2.4.1.186;3.5.1.92;3.1.4.4", "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0030246 carbohydrate binding;GO:0090599 alpha-glucosidase activity;GO:0043896 glucan 1,6-alpha-glucosidase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0120282 autolysosome lumen;GO:0005576 extracellular region", "go_biological_process": "GO:0007626 locomotory behavior;GO:0046716 muscle cell cellular homeostasis;GO:0050885 neuromuscular process controlling balance;GO:0005977 glycogen metabolic process;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P70699-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01102-1", "uniprot_id": "LYAM3_MOUSE", "mass": 83099.0, "length": 768, "protein_name": "P-selectin", "gene_name": "Selp", "organism": "Mouse", "refseq_name": "P-selectin precursor", "refseq_ac": "NP_035477", "gene_names_uniprotkb": "Selp; Grmp", "gene_names_refseq": "CD62P; GMP-140; Grmp; LECAM3; PADGEM; Selp", "protein_names_uniprotkb": "P-selectin; CD62 antigen-like family member P; GMP-140; Granule membrane protein 140; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein", "protein_names_refseq": "CD62 antigen-like family member P; P-selectin precursor; P-selectin; granule membrane protein 140; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); brain small vessel disease (Disease Ontology:DOID:0112313); Alzheimer's disease (Disease Ontology:DOID:10652); Sjogren's syndrome (Disease Ontology:DOID:12894); Kawasaki disease (Disease Ontology:DOID:13378); atherosclerosis (Disease Ontology:DOID:1936); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ulcerative colitis (Disease Ontology:DOID:8577); intermediate coronary syndrome (Disease Ontology:DOID:8805); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20344); (R-MMU-114608); (R-MMU-202733)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12370362;12393631;1378846;1379089;21750661;25428506;30779550;34428180;37322469;38355315;39627609", "class_list": "glycogene", "function": "A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage. Publication Status: Online-Only, [RefSeq, PubMed]; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3) (By similarity)., [UniProtKB, PubMed, UniProtKB]; Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 62, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q32MF1", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0031092 platelet alpha granule membrane", "go_biological_process": "GO:0033623 regulation of integrin activation;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0045785 positive regulation of cell adhesion;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q01102-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q505F5-1", "uniprot_id": "LRC47_MOUSE", "mass": 63590.0, "length": 581, "protein_name": "Leucine-rich repeat-containing protein 47", "gene_name": "Lrrc47", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 47", "refseq_ac": "NP_957678", "gene_names_uniprotkb": "Lrrc47; Kiaa1185", "gene_names_refseq": "2900010D03Rik; Lrrc47; mKIAA1185", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 47", "protein_names_refseq": "leucine-rich repeat-containing protein 47", "tax_id": 10090, "disease": "", "pathway": " (mmu:72946)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28528544;31219806;34428180;34887587;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U380;Q6ZPW2;Q9CUZ0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004826 phenylalanine-tRNA ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0006432 phenylalanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q505F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVA4-1", "uniprot_id": "LMOD1_MOUSE", "mass": 66310.0, "length": 595, "protein_name": "Leiomodin-1", "gene_name": "Lmod1", "organism": "Mouse", "refseq_name": "leiomodin-1", "refseq_ac": "NP_444336", "gene_names_uniprotkb": "Lmod1", "gene_names_refseq": "9530015K06Rik; Lmod1; SM-Lmod", "protein_names_uniprotkb": "Leiomodin-1", "protein_names_refseq": "leiomodin-1", "tax_id": 10090, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610)", "pathway": " (mmu:93689); (R-MMU-445355)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;22157009;28292896", "class_list": "", "function": "Lmod1 is a new SMC-restricted SRF/MYOCD target gene., [RefSeq, PubMed]; Loss of LMOD1 results in a reduction of filamentous actin, elongated cytoskeletal dense bodies, and impaired intestinal smooth muscle contractility., [RefSeq, PubMed]; Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments (By similarity)., [UniProtKB, UniProtKB, PubMed]; Required for proper contractility of visceral smooth muscle cells. Mediates nucleation of actin filaments., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0045010 actin nucleation;GO:0030838 positive regulation of actin filament polymerization;GO:0051694 pointed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BVA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W89-1", "uniprot_id": "MA2C1_MOUSE", "mass": 115688.0, "length": 1039, "protein_name": "Alpha-mannosidase 2C1", "gene_name": "Man2c1", "organism": "Mouse", "refseq_name": "alpha-mannosidase 2C1", "refseq_ac": "NP_082912", "gene_names_uniprotkb": "Man2c1", "gene_names_refseq": "1110025H24Rik; Man2c1", "protein_names_uniprotkb": "Alpha-mannosidase 2C1; 3.2.1.24; Alpha-D-mannoside mannohydrolase; Mannosidase alpha class 2C member 1; Neutral/cytosolic alpha-mannosidase", "protein_names_refseq": "alpha-D-mannoside mannohydrolase; alpha-mannosidase 2C1; cytosolic alpha-D-mannosidase; neutral/cytosolic alpha-mannosidase", "tax_id": 10090, "disease": "congenital disorder of deglycosylation 2 (Disease Ontology:DOID:0060990)", "pathway": " (mmu:73744); (R-MMU-8853383)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16904268;21750661;24550399;34428180;37507081", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Comparison of the mouse genomic sequence with the cDNA sequence revealed the presence of 25 introns within the cytosolic alpha-mannosidase gene. The gene spans 11.5 kb from the major transcription initiation site to the RNA cleavage site., [RefSeq, PubMed]; These findings confirm the key role played by Man2c1 in the catabolism of free oligosaccharides., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 57, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCX9", "ec_number_list": "3.2.1.24", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006013 mannose metabolic process;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91W89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRX9-1", "uniprot_id": "MARH3_MOUSE", "mass": 24491.0, "length": 218, "protein_name": "E3 ubiquitin-protein ligase MARCHF3", "gene_name": "Marchf3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF3 isoform 2", "refseq_ac": "NP_796089", "gene_names_uniprotkb": "Marchf3; March3", "gene_names_refseq": "6330411I15Rik; A530081L18Rik; MARCH-III; March3; Marchf3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF3; 2.3.2.27; MARCH-III; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING-type E3 ubiquitin transferase MARCHF3", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH3; E3 ubiquitin-protein ligase MARCHF3 isoform 2; E3 ubiquitin-protein ligase MARCHF3; RING-type E3 ubiquitin transferase MARCH3; RING-type E3 ubiquitin transferase MARCHF3; membrane-associated RING finger protein 3; membrane-associated RING-CH protein III; membrane-associated ring finger (C3HC4) 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:320253)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;35075102;35982175", "class_list": "", "function": "E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha. Publication Status: Online-Only, [RefSeq, PubMed]; The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNK5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BRX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07174-1", "uniprot_id": "M3K8_MOUSE", "mass": 52942.0, "length": 467, "protein_name": "Mitogen-activated protein kinase kinase kinase 8", "gene_name": "Map3k8", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 8", "refseq_ac": "NP_031772", "gene_names_uniprotkb": "Map3k8; Cot; Tpl2", "gene_names_refseq": "Cot/Tpl2; Cot; Estf; Est; Map3k8; Tpl-2; Tpl2; c-COT", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 8; 2.7.11.25; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; TPL-2; Tumor progression locus 2", "protein_names_refseq": "COT proto-oncogene serine/threonine-protein kinase; cancer Osaka thyroid oncogene; mitogen-activated protein kinase kinase kinase 8; proto-oncogene c-Cot; serine/threonine-protein kinase cot; tumor progression locus 2", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); lung non-small cell carcinoma (Disease Ontology:DOID:3908); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:26410); (R-MMU-389357); (R-MMU-5684264)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11163183;12667451;12881420;15833743;19001140;19808894;20173027;21750661;23842752;30084848;30779550;31599954;35980186;37555828;8320169", "class_list": "", "function": "Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice. Publication Status: Online-Only, [RefSeq, PubMed]; Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000165 MAPK cascade;GO:0050729 positive regulation of inflammatory response;GO:0002376 immune system process;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q07174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3W5-1", "uniprot_id": "LRC71_MOUSE", "mass": 61351.0, "length": 558, "protein_name": "Leucine-rich repeat-containing protein 71", "gene_name": "Lrrc71", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 71", "refseq_ac": "NP_083247", "gene_names_uniprotkb": "Lrrc71; 4933430H15Rik", "gene_names_refseq": "4933430H15Rik; Lrrc71", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 71", "protein_names_refseq": "leucine-rich repeat-containing protein 71; leucine-rich repeat-containing protein C10orf92 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74485)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0S9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D3W5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62322-1", "uniprot_id": "LSM5_MOUSE", "mass": 9937.0, "length": 91, "protein_name": "U6 snRNA-associated Sm-like protein LSm5", "gene_name": "Lsm5", "organism": "Mouse", "refseq_name": "U6 snRNA-associated Sm-like protein LSm5", "refseq_ac": "NP_079796", "gene_names_uniprotkb": "Lsm5", "gene_names_refseq": "2010208O10Rik; 2310034K10Rik; Lsm5", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm5", "protein_names_refseq": "LSM5 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66373); (R-MMU-430039); (R-MMU-72163)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTT1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0120115 Lsm2-8 complex", "go_biological_process": "GO:0009617 response to bacterium;GO:0006402 mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62322-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54791-1", "uniprot_id": "MAFF_MOUSE", "mass": 16955.0, "length": 156, "protein_name": "Transcription factor MafF", "gene_name": "Maff", "organism": "Mouse", "refseq_name": "transcription factor MafF", "refseq_ac": "NP_001291759", "gene_names_uniprotkb": "Maff", "gene_names_refseq": "Maff", "protein_names_uniprotkb": "Transcription factor MafF; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F", "protein_names_refseq": "V-maf musculoaponeurotic fibrosarcoma oncogene homolog F; transcription factor MafF; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F", "tax_id": 10090, "disease": "", "pathway": " (mmu:17133); (R-MMU-983231)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10409670;21750661;33626882;39412062", "class_list": "", "function": "HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis., [RefSeq, PubMed]; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition., [UniProtKB, UniProtKB]; Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70582-1", "uniprot_id": "LX12B_MOUSE", "mass": 80578.0, "length": 701, "protein_name": "Arachidonate 12-lipoxygenase, 12R-type", "gene_name": "Alox12b", "organism": "Mouse", "refseq_name": "arachidonate 12-lipoxygenase, 12R-type", "refseq_ac": "NP_033789", "gene_names_uniprotkb": "Alox12b; Aloxe2", "gene_names_refseq": "12R-LOX; Alox12b; Aloxe2; e-LOX2", "protein_names_uniprotkb": "Arachidonate 12-lipoxygenase, 12R-type; 1.13.11.-; 12R-LOX; 12R-lipoxygenase; Epidermis-type lipoxygenase 12; Epidermis-type lipoxygenase 2; e-LOX 2", "protein_names_refseq": "12R-lipoxygenase; arachidonate 12-lipoxygenase, 12R-type; epidermis-type lipoxygenase 12; epidermis-type lipoxygenase 2", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 2 (Disease Ontology:DOID:0060710)", "pathway": " (mmu:11686); (R-MMU-2142712)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10100631;11256953;16129665;17403930;17429434;21558561;23954555;33607042;34428180;36116510;9518531;9837935", "class_list": "", "function": "ALOX12B and PNPLA1 Have Distinct Roles in Epidermal Lipid Lamellar Organization., [RefSeq, PubMed]; Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:16129665). Does not convert arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE (PubMed:10100631, PubMed:11256953). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:17403930, PubMed:17429434, PubMed:21558561). May also play a role in the regulation of the expression of airway mucins (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis. [review] Review article Erratum:[Biochim Biophys Acta. 2014 Dec;1841(12):1767], [RefSeq, PubMed]; This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyosiform phenotype. [provided by RefSeq, Sep 2015]., [RefSeq]; Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support a Specific Role in Lipid-Protein Cross-Linking., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.13.11.-;1.13.11.31", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:1990136 linoleate 9S-lipoxygenase activity;GO:0047677 arachidonate 8(R)-lipoxygenase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O70582-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89029-1", "uniprot_id": "MATN4_MOUSE", "mass": 68918.0, "length": 624, "protein_name": "Matrilin-4", "gene_name": "Matn4", "organism": "Mouse", "refseq_name": "matrilin-4 precursor", "refseq_ac": "NP_001239492", "gene_names_uniprotkb": "Matn4", "gene_names_refseq": "Matn4; matrilin-4", "protein_names_uniprotkb": "Matrilin-4; MAT-4", "protein_names_refseq": "MAT-4; matrilin-4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17183)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12009334;21750661;9771906;9827539", "class_list": "", "function": "Expression of matrilin-4 during maturation of mouse skeletal tissues, [RefSeq, PubMed]; Major component of the extracellular matrix of cartilage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O89030;Q9QWS3", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0120216 matrilin complex", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0048678 response to axon injury", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O89029-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01725-1", "uniprot_id": "LV1C_MOUSE", "mass": 11654.0, "length": 110, "protein_name": "Ig lambda-1 chain V region S178", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-1 chain V region S178", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "4516208", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01725-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01727-1", "uniprot_id": "LV1E_MOUSE", "mass": 13529.0, "length": 129, "protein_name": "Ig lambda-1 chain V region S43", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-1 chain V region S43", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6283385", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11260-1", "uniprot_id": "LORF1_MOUSE", "mass": 41226.0, "length": 357, "protein_name": "LINE-1 retrotransposable element ORF1 protein", "gene_name": "Lire1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lire1", "gene_names_refseq": "", "protein_names_uniprotkb": "LINE-1 retrotransposable element ORF1 protein; L1-ORF1p; LINE retrotransposable element 1; LINE1 retrotransposable element 1; Transposase element L1Md-A101/L1Md-A102/L1Md-A2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "11134335;11591644;14615577;17569664;28662698;28806172;3023821;34428180", "class_list": "", "function": "Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91V68", "ec_number_list": "", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032197 retrotransposition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18165-1", "uniprot_id": "LORI_MOUSE", "mass": 38200.0, "length": 486, "protein_name": "Loricrin", "gene_name": "Loricrin", "organism": "Mouse", "refseq_name": "loricrin", "refseq_ac": "NP_032534", "gene_names_uniprotkb": "Loricrin; Lor", "gene_names_refseq": "Loricrin; Lor", "protein_names_uniprotkb": "Loricrin", "protein_names_refseq": "loricrin", "tax_id": 10090, "disease": "", "pathway": " (mmu:16939)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11038186;20485683;2190691;24751727;32758484;7738016", "class_list": "", "function": "Major keratinocyte cell envelope protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0I9", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009898 cytoplasmic side of plasma membrane;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18165-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18337-1", "uniprot_id": "LYAM1_MOUSE", "mass": 42288.0, "length": 372, "protein_name": "L-selectin", "gene_name": "Sell", "organism": "Mouse", "refseq_name": "L-selectin isoform 1 precursor", "refseq_ac": "NP_035476", "gene_names_uniprotkb": "Sell; Lnhr; Ly-22; Ly22", "gene_names_refseq": "CD62L; L-selectin; LAM-1; LECAM-1; LECAM1; Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1; Sell", "protein_names_uniprotkb": "L-selectin; CD62 antigen-like family member L; LAM-1; LECAM1; Leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 1; Ly-22; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen", "protein_names_refseq": "CD62 antigen-like family member L; L-selectin isoform 1 precursor; leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 1; lymph node homing receptor; lymphocyte antigen 22; lymphocyte surface MEL-14 antigen", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); toxic shock syndrome (Disease Ontology:DOID:14115); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis (Disease Ontology:DOID:2237); endometriosis (Disease Ontology:DOID:289); IgA glomerulonephritis (Disease Ontology:DOID:2986); peripheral vascular disease (Disease Ontology:DOID:341); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); abdominal aortic aneurysm (Disease Ontology:DOID:7693); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20343); (R-MMU-198933); (R-MMU-202733); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1693096;2004776;21750661;2646713;2647302;34428180;38060451", "class_list": "glycogene", "function": "CD62L expression marks a functionally distinct subset of memory B cells., [RefSeq, PubMed]; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes (PubMed:1693096). Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0002020 protease binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0034097 response to cytokine;GO:0042981 regulation of apoptotic process;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050901 leukocyte tethering or rolling;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21812-1", "uniprot_id": "MCPT4_MOUSE", "mass": 27204.0, "length": 246, "protein_name": "Mast cell protease 4", "gene_name": "Mcpt4", "organism": "Mouse", "refseq_name": "mast cell protease 4 precursor", "refseq_ac": "NP_034909", "gene_names_uniprotkb": "Mcpt4", "gene_names_refseq": "MMCP-4A; MMCP-4B; MMCP-4; Mcp-4; Mcp4; Mcpt4", "protein_names_uniprotkb": "Mast cell protease 4; 3.4.21.-; MSMCP; Myonase; Serosal mast cell protease; mMCP-4", "protein_names_refseq": "MSMCP; mast cell protease 4 precursor; myonase; serosal mast cell protease", "tax_id": 10090, "disease": "", "pathway": " (mmu:17227)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11141502;12900518;1988455;2060576;20940421;2326280;31866111;33154104;35154114;8363563;9538257", "class_list": "", "function": "Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing., [UniProtKB, PubMed, PubMed]; Mast Cell Chymase/Mcpt4 Suppresses the Host Immune Response to Plasmodium yoelii, Limits Malaria-Associated Disruption of Intestinal Barrier Integrity and Reduces Parasite Transmission to Anopheles stephensi. Publication Status: Online-Only, [RefSeq, PubMed]; Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I., [RefSeq, PubMed]; Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPQ9;Q9EQT2", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:0002002 regulation of angiotensin levels in blood", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P21812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21843-1", "uniprot_id": "MCPT3_MOUSE", "mass": 2328.0, "length": 21, "protein_name": "Mast cell protease 3", "gene_name": "Mcpt3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mcpt3", "gene_names_refseq": "", "protein_names_uniprotkb": "Mast cell protease 3; 3.4.21.-; mMCP-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2326280;8505310", "class_list": "", "function": "Thrombin inactivating protease. Displays chymotrypsin-like substrate specificity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008236 serine-type peptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51942-1", "uniprot_id": "MATN1_MOUSE", "mass": 54421.0, "length": 500, "protein_name": "Matrilin-1", "gene_name": "Matn1", "organism": "Mouse", "refseq_name": "matrilin-1 precursor", "refseq_ac": "NP_034899", "gene_names_uniprotkb": "Matn1; Cmp; Crtm", "gene_names_refseq": "CMP; Crtm; Mat1; Matn1; matrilin-1", "protein_names_uniprotkb": "Matrilin-1; Cartilage matrix protein", "protein_names_refseq": "cartilage matrix protein; matrilin 1, cartilage matrix protein 1; matrilin-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17180)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10633862;24692560;27270603;35820727;8665920", "class_list": "", "function": "A major component of the extracellular matrix of non-articular cartilage (By similarity). Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix (By similarity). Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy (PubMed:10633862). Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1 (PubMed:27270603). Acts as a moderator of angiogenesis in response to injury (PubMed:24692560)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80VN5", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0002062 chondrocyte differentiation;GO:0030500 regulation of bone mineralization;GO:0003429 growth plate cartilage chondrocyte morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P51942-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55249-1", "uniprot_id": "LX12E_MOUSE", "mass": 75456.0, "length": 662, "protein_name": "Polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type", "gene_name": "Alox12e", "organism": "Mouse", "refseq_name": "polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type", "refseq_ac": "NP_663717", "gene_names_uniprotkb": "Alox12e; Alox12-ps2; Aloxe", "gene_names_refseq": "12-LOX-e; 12-LOX; 8-LOX; Alox12-ps1; Alox12-ps2; Alox12e; Aloxe; e-LOX1", "protein_names_uniprotkb": "Polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type; 1.13.11.-; 1.13.11.31; 12-LOX-e; Arachidonate (12S)-lipoxygenase, epidermal-type; Linoleate (13S)-lipoxygenase; e(12S)-LOX", "protein_names_refseq": "arachidonate (12S)-lipoxygenase, epidermal-type; arachidonate 12-lipoxygenase, epidermal-type; arachidonate 12-lipoxygenase, epidermal; e(12S)-LOX; linoleate (13S)-lipoxygenase; polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type", "tax_id": 10090, "disease": "", "pathway": " (mmu:11685)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11256953;30084848;31353262;34428180;35158337;7492614;8798535;9037187", "class_list": "", "function": "12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Erratum:[Cell Metab. 2025 Dec 2;37(12):2470-2475. doi: 10.1016/j.cmet.2025.10.019. PMID: 41197629], [RefSeq, PubMed]; Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:11256953, PubMed:8798535, PubMed:9037187). Shows increasing catalytic activity within the series arachidonic acid < 5,8,11-eicosatrienoic acid < linoleic acid < 8,11,14-eicosatrienoic acid (PubMed:11256953)., [UniProtKB, PubMed, PubMed, PubMed]; Senescence-associated tumor growth is promoted by 12-Lipoxygenase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YW6", "ec_number_list": "1.13.11.-;1.13.11.31;1.13.11.33;1.13.11.12;1.13.11.34", "go_molecular_function": "GO:0005506 iron ion binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0050473 arachidonate 15-lipoxygenase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0034440 lipid oxidation;GO:0019372 lipoxygenase pathway;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P55249-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58500-1", "uniprot_id": "M3KCL_MOUSE", "mass": 16271.0, "length": 142, "protein_name": "MAP3K7 C-terminal-like protein", "gene_name": "Map3k7cl", "organism": "Mouse", "refseq_name": "MAP3K7 C-terminal-like protein", "refseq_ac": "NP_659103", "gene_names_uniprotkb": "Map3k7cl; ORF63; Tak1l", "gene_names_refseq": "C21orf7; Map3k7cl; ORF63; Tak1l", "protein_names_uniprotkb": "MAP3K7 C-terminal-like protein; TAK1-like protein", "protein_names_refseq": "MAP3K7 C-terminal-like protein; TAK1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:224419)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11707072", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58500-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60853-1", "uniprot_id": "LZTS1_MOUSE", "mass": 67290.0, "length": 599, "protein_name": "Leucine zipper putative tumor suppressor 1", "gene_name": "Lzts1", "organism": "Mouse", "refseq_name": "leucine zipper putative tumor suppressor 1", "refseq_ac": "NP_955396", "gene_names_uniprotkb": "Lzts1; Fez1", "gene_names_refseq": "F37; FEZ1; Lzts1; PSD-Zip70", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; Fez1", "protein_names_refseq": "F37 esophageal cancer-related leucine zipper motif 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; leucine zipper putative tumor suppressor 1; leucine-zipper protein FEZ1", "tax_id": 10090, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (mmu:211134)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10097140;17349584;17419986;18192690", "class_list": "", "function": "Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity)., [UniProtKB]; Loss of one or both LZTS1 alleles hampers the normal defenses of urothelial cells against carcinogens, favoring bladder cancer development, which may make FEZ1 a target for gene therapy., [RefSeq, PubMed]; Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice., [RefSeq, PubMed]; Partial or complete loss of Lzts1 downregulates Cdc25C and inhibits Cdk1 activity during mitosis, leading to premature transition from metaphase to anaphase., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RTI1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0043197 dendritic spine;GO:0043198 dendritic shaft;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0048167 regulation of synaptic plasticity;GO:0016242 negative regulation of macroautophagy;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P60853-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62313-1", "uniprot_id": "LSM6_MOUSE", "mass": 9128.0, "length": 80, "protein_name": "U6 snRNA-associated Sm-like protein LSm6", "gene_name": "Lsm6", "organism": "Mouse", "refseq_name": "U6 snRNA-associated Sm-like protein LSm6", "refseq_ac": "NP_001177933", "gene_names_uniprotkb": "Lsm6", "gene_names_refseq": "1500031N17Rik; 2410088K19Rik; Lsm6", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm6", "protein_names_refseq": "LSM6 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm6", "tax_id": 10090, "disease": "", "pathway": " (mmu:78651); (R-MMU-430039); (R-MMU-72163)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "25428506;25605945;34428180", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Y4Y8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0000932 P-body", "go_biological_process": "GO:0008033 tRNA processing;GO:0006402 mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70202-1", "uniprot_id": "LXN_MOUSE", "mass": 25492.0, "length": 222, "protein_name": "Latexin", "gene_name": "Lxn", "organism": "Mouse", "refseq_name": "latexin", "refseq_ac": "NP_058033", "gene_names_uniprotkb": "Lxn", "gene_names_refseq": "Lxn", "protein_names_uniprotkb": "Latexin; ECI; Endogenous carboxypeptidase inhibitor; TCI; Tissue carboxypeptidase inhibitor", "protein_names_refseq": "ECI; TCI; endogenous carboxypeptidase inhibitor; latexin; tissue carboxypeptidase inhibitor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17035)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15698574;18250455;26495903;35820727;36933218;9119386", "class_list": "", "function": "Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation., [UniProtKB, PubMed]; Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1. Erratum:[Cell Rep. 2026 Mar 24;45(3):117153. doi: 10.1016/j.celrep.2026.117153. PMID: 41793714], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDQ0;Q8CCS8", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00690-1", "uniprot_id": "LYAM2_MOUSE", "mass": 66750.0, "length": 612, "protein_name": "E-selectin", "gene_name": "Sele", "organism": "Mouse", "refseq_name": "E-selectin precursor", "refseq_ac": "NP_035475", "gene_names_uniprotkb": "Sele; Elam-1", "gene_names_refseq": "CD62E; E-selectin; ELAM-1; Elam; LECAM2; Sele", "protein_names_uniprotkb": "E-selectin; CD62 antigen-like family member E; ELAM-1; Endothelial leukocyte adhesion molecule 1; LECAM2; Leukocyte-endothelial cell adhesion molecule 2", "protein_names_refseq": "CD62 antigen-like family member E; E-selectin precursor; endothelial leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 2", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); aortic atherosclerosis (Disease Ontology:DOID:10230); brain ischemia (Disease Ontology:DOID:2316); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); cerebrovascular disease (Disease Ontology:DOID:6713); rheumatic myocarditis (Disease Ontology:DOID:8481); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20339); (R-MMU-202733)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1375914;1378846;35013188;37930129;38428409", "class_list": "glycogene", "function": "Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1 (PubMed:1375914). May have a role in capillary morphogenesis., [UniProtKB, UniProtKB, PubMed]; Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG., [RefSeq, PubMed]; PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay., [RefSeq, PubMed]; Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 53, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0004888 transmembrane signaling receptor activity;GO:0005509 calcium ion binding;GO:0033691 sialic acid binding;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0007159 leukocyte cell-cell adhesion;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0034097 response to cytokine;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q00690-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05512-1", "uniprot_id": "MARK2_MOUSE", "mass": 86306.0, "length": 776, "protein_name": "Serine/threonine-protein kinase MARK2", "gene_name": "Mark2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase MARK2 isoform 2", "refseq_ac": "NP_001073857", "gene_names_uniprotkb": "Mark2; Emk", "gene_names_refseq": "EMK-1; Emk; Mark2; Par-1b; Par-1", "protein_names_uniprotkb": "Serine/threonine-protein kinase MARK2; 2.7.11.1; 2.7.11.26; ELKL motif kinase 1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR1 homolog b; PAR1 homolog; Par-1b; mPar-1b", "protein_names_refseq": "ELKL motif kinase 1; PAR1 homolog b; serine/threonine-protein kinase MARK2 isoform 2; serine/threonine-protein kinase MARK2", "tax_id": 10090, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:13728)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10491259;11287624;17242355;17372192;18299400;19144319;21183079;21750661;22645316;22872234;25428506;27465397;30084848;30779550;31219806;32841502;33300544;34428180;38709923;8358177", "class_list": "", "function": "LKB1-MARK2 signalling mediates lipopolysaccharide-induced production of cytokines in mouse macrophages., [RefSeq, PubMed]; MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites., [RefSeq, PubMed]; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of disheveled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Phosphorylates UBAC2 at 'Ser-223' during ER stress or starvation-induced autophagy, promoting UBAC2 dimerization and interaction with GABARAP to mediate ER-phagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9L3;Q6PDR4;Q8BR95", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0048156 tau protein binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0006468 protein phosphorylation;GO:0010976 positive regulation of neuron projection development;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q05512-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0ZCJ7-1", "uniprot_id": "MASTR_MOUSE", "mass": 45403.0, "length": 421, "protein_name": "MEF2-activating motif and SAP domain-containing transcriptional regulator", "gene_name": "Mamstr", "organism": "Mouse", "refseq_name": "MEF2-activating motif and SAP domain-containing transcriptional regulator", "refseq_ac": "NP_766006", "gene_names_uniprotkb": "Mamstr; Mastr", "gene_names_refseq": "2810022D01Rik; 5430432N15Rik; Mamstr; Mastr", "protein_names_uniprotkb": "MEF2-activating motif and SAP domain-containing transcriptional regulator; MEF2-activating SAP transcriptional regulatory protein", "protein_names_refseq": "MEF2-activating SAP transcriptional regulatory protein; MEF2-activating motif and SAP domain-containing transcriptional regulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:74490)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16818234;21750661;31348492", "class_list": "", "function": "Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD, [RefSeq, PubMed]; Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A1L0X1;E9QM68;Q3B818", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0ZCJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14DL3-1", "uniprot_id": "LRIQ3_MOUSE", "mass": 75364.0, "length": 633, "protein_name": "Leucine-rich repeat and IQ domain-containing protein 3", "gene_name": "Lrriq3", "organism": "Mouse", "refseq_name": "leucine-rich repeat and IQ domain-containing protein 3", "refseq_ac": "NP_083214", "gene_names_uniprotkb": "Lrriq3; Lrrc44", "gene_names_refseq": "4930438B07Rik; 4930511J15Rik; 4933403H06Rik; Lrrc44; Lrriq3", "protein_names_uniprotkb": "Leucine-rich repeat and IQ domain-containing protein 3; Leucine-rich repeat-containing protein 44", "protein_names_refseq": "leucine rich repeat containing 44; leucine-rich repeat and IQ domain-containing protein 3; leucine-rich repeat-containing protein 44", "tax_id": 10090, "disease": "", "pathway": " (mmu:74435)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4C3;Q9D562;Q9D5I0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q14DL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1HKZ5-1", "uniprot_id": "M3K13_MOUSE", "mass": 106987.0, "length": 959, "protein_name": "Mitogen-activated protein kinase kinase kinase 13", "gene_name": "Map3k13", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 13", "refseq_ac": "NP_766409", "gene_names_uniprotkb": "Map3k13", "gene_names_refseq": "C130026N12Rik; LZK; Map3k13", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 13; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:71751)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20926658;29590625;32848054;33475086;35361703;40021952", "class_list": "", "function": "A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord., [RefSeq, PubMed]; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity)., [UniProtKB]; Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Erratum:[Elife. 2023 Feb 13;12:e86472. doi: 10.7554/eLife.86472. PMID: 36779959] Publication Status: Online-Only, [RefSeq, PubMed]; LZK overexpression in astrocytes enhanced astrogliosis and reduced lesion size. Remarkably, in the absence of injury, LZK overexpression alone induced widespread astrogliosis in the CNS and upregulated astrogliosis activators pSTAT3 and SOX9., [RefSeq, PubMed]; Scaffold protein POSH, in association with Shroom3 and mixed lineage kinase LZK, relays axon outgrowth inhibition downstream of NogoA and PirB proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKN0", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:1905492 positive regulation of branching morphogenesis of a nerve;GO:0006468 protein phosphorylation;GO:0007254 JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q1HKZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2KHI9-1", "uniprot_id": "MCM9_MOUSE", "mass": 125814.0, "length": 1134, "protein_name": "DNA helicase MCM9", "gene_name": "Mcm9", "organism": "Mouse", "refseq_name": "DNA helicase MCM9", "refseq_ac": "NP_082106", "gene_names_uniprotkb": "Mcm9; Mcmdc1", "gene_names_refseq": "9030408O17Rik; Gm235; Mcm9; Mcmdc1", "protein_names_uniprotkb": "DNA helicase MCM9; 5.6.2.4; DNA 3'-5' helicase MCM9; Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9", "protein_names_refseq": "DNA 3'-5' helicase MCM9; DNA helicase MCM9; DNA replication licensing factor MCM9; mini-chromosome maintenance deficient 9; mini-chromosome maintenance deficient domain-containing protein 1; minichromosome maintenance complex component 9", "tax_id": 10090, "disease": "ovarian dysgenesis 4 (Disease Ontology:DOID:0080496); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:71567)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15850810;16226853;21750661;21987787;22645316;22771120;23401855;26300262;26388201;31509747;34203471;34428180;39627609", "class_list": "", "function": "Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:22771120, PubMed:23401855). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (By similarity). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex at double-stranded DNA breaks to generate ssDNA by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (By similarity). Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex (PubMed:22771120, PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:22771120, PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (By similarity). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:21987787). Probably by regulating HR, plays a key role during gametogenesis (PubMed:21987787, PubMed:22771120)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Genetic studies of DNA damage response pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9, [RefSeq, PubMed]; Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells., [RefSeq, PubMed]; MCM8 and MCM9 form a complex and that they coregulate their stability., [RefSeq, PubMed]; MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. Erratum:[Cell Rep. 2026 Jan 27;45(1):116846. doi: 10.1016/j.celrep.2025.116846. PMID: 41417734], [RefSeq, PubMed]; Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V370;Q6P6J6;Q9D344", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0097362 MCM8-MCM9 complex;GO:0042555 MCM complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0007292 female gamete generation;GO:0071168 protein localization to chromatin;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q2KHI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BKQ4-1", "uniprot_id": "LIPR1_MOUSE", "mass": 52696.0, "length": 473, "protein_name": "Inactive pancreatic lipase-related protein 1", "gene_name": "Pnliprp1", "organism": "Mouse", "refseq_name": "inactive pancreatic lipase-related protein 1 precursor", "refseq_ac": "NP_061362", "gene_names_uniprotkb": "Pnliprp1", "gene_names_refseq": "Plrp1; Pnliprp1", "protein_names_uniprotkb": "Inactive pancreatic lipase-related protein 1; PL-RP1", "protein_names_refseq": "PL-RP1; inactive pancreatic lipase-related protein 1 precursor; inactive pancreatic lipase-related protein 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:18946); (R-MMU-192456)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10235541;21115337;21750661", "class_list": "", "function": "In vitro, it has very low or undetectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (By similarity). Unable to hydrolyze milk fat (in vitro) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We propose that PLRP1 may function as a metabolic inhibitor in vivo of pancreatic triglyceride lipase-colipase-mediated dietary triglyceride digestion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70478;Q6NV82", "ec_number_list": "", "go_molecular_function": "GO:0016298 lipase activity;GO:0005509 calcium ion binding;GO:0008970 phospholipase A1 activity;GO:0004465 lipoprotein lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0019433 triglyceride catabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5BKQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FWC3-1", "uniprot_id": "M4A13_MOUSE", "mass": 22802.0, "length": 203, "protein_name": "Membrane-spanning 4-domains subfamily A member 13", "gene_name": "Ms4a13", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 13 isoform 2", "refseq_ac": "NP_001334364", "gene_names_uniprotkb": "Ms4a13", "gene_names_refseq": "1700060E18Rik; Ms4a13; Tetm4.2", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 13; Testis-expressed transmembrane protein 4.2; Tetm4.2", "protein_names_refseq": "membrane-spanning 4-domains subfamily A member 13 isoform 2; testis-expressed transmembrane 4; testis-expressed transmembrane protein 4.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:73466)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q717T1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FWC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M8M9-1", "uniprot_id": "LRC52_MOUSE", "mass": 35295.0, "length": 314, "protein_name": "Leucine-rich repeat-containing protein 52", "gene_name": "Lrrc52", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 52 precursor", "refseq_ac": "NP_001013400", "gene_names_uniprotkb": "Lrrc52", "gene_names_refseq": "4930413P14Rik; Lrrc52", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 52; BK channel auxiliary gamma subunit LRRC52", "protein_names_refseq": "BK channel auxiliary gamma subunit LRRC52; BK channel auxilliary gamma subunit LRRC52; leucine-rich repeat-containing protein 52 precursor; leucine-rich repeat-containing protein 52", "tax_id": 10090, "disease": "", "pathway": " (mmu:240899)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22084117;25675513;31348683;31451634", "class_list": "", "function": "Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). KCNU1 channel auxiliary protein. Modulates KCNU1 gating properties, shifting KCNU1 gating to more negative potentials at a given pH (PubMed:22084117, PubMed:25675513)., [UniProtKB, PubMed, PubMed]; LRRC52 and LRRC26 define a new family of auxiliary subunits capable of critically modifying the gating behavior of Slo family channels., [RefSeq, PubMed]; LRRC52 is a gamma2 subunit of Big conductance and voltage- and Ca(2+)-activated K(+) channel complexes, [RefSeq, PubMed]; LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells., [RefSeq, PubMed]; These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0006813 potassium ion transport;GO:1903818 positive regulation of voltage-gated potassium channel activity;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5M8M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60948-1", "uniprot_id": "MAD4_MOUSE", "mass": 23590.0, "length": 209, "protein_name": "Max dimerization protein 4", "gene_name": "Mxd4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mxd4; Mad4", "gene_names_refseq": "", "protein_names_uniprotkb": "Max dimerization protein 4; Max dimerizer 4; Max-associated protein 4; Max-interacting transcriptional repressor MAD4", "protein_names_refseq": "", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10597267;8521822", "class_list": "", "function": "Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60948-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61809-1", "uniprot_id": "LRRN1_MOUSE", "mass": 80548.0, "length": 716, "protein_name": "Leucine-rich repeat neuronal protein 1", "gene_name": "Lrrn1", "organism": "Mouse", "refseq_name": "leucine-rich repeat neuronal protein 1 precursor", "refseq_ac": "NP_032542", "gene_names_uniprotkb": "Lrrn1; Kiaa1497", "gene_names_refseq": "2810047E21Rik; Lrrn1; NLRR-1", "protein_names_uniprotkb": "Leucine-rich repeat neuronal protein 1; NLRR-1; Neuronal leucine-rich repeat protein 1", "protein_names_refseq": "leucine-rich repeat neuronal protein 1 precursor", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:16979)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15893969;27604320;35820727;37369584;8717337", "class_list": "", "function": "Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti., [RefSeq, PubMed]; NLRR-1 is expressed in a subset of myotome cells., [RefSeq, PubMed]; NLRR1 appears to be an extracellular negative regulator of ALK signalling in neuroblastoma and neuronal development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3USY1;Q69ZI0", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61809-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61826-1", "uniprot_id": "MADCA_MOUSE", "mass": 43652.0, "length": 405, "protein_name": "Mucosal addressin cell adhesion molecule 1", "gene_name": "Madcam1", "organism": "Mouse", "refseq_name": "mucosal addressin cell adhesion molecule 1 isoform 2 precursor", "refseq_ac": "NP_001345714", "gene_names_uniprotkb": "Madcam1", "gene_names_refseq": "MAdCAM-1; Madcam1", "protein_names_uniprotkb": "Mucosal addressin cell adhesion molecule 1; MAdCAM-1; mMAdCAM-1", "protein_names_refseq": "mucosal addressin cell adhesion molecule 1 isoform 2 precursor; mucosal addressin cell adhesion molecule 1", "tax_id": 10090, "disease": "food allergy (Disease Ontology:DOID:3044); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:17123); (R-MMU-198933); (R-MMU-216083)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21750661;3340147;34428180;7488084;7505053;7650378;7687523;7693764;7724598;8502297;9316640", "class_list": "glycogene", "function": "Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35530;Q61278;Q64275;Q8R1M6", "ec_number_list": "", "go_molecular_function": "GO:0098640 integrin binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0030216 keratinocyte differentiation;GO:0050900 leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61826-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TE3-1", "uniprot_id": "MARH4_MOUSE", "mass": 45201.0, "length": 409, "protein_name": "E3 ubiquitin-protein ligase MARCHF4", "gene_name": "Marchf4", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF4 isoform 1 precursor", "refseq_ac": "NP_001038998", "gene_names_uniprotkb": "Marchf4; Kiaa1399; March4", "gene_names_refseq": "MARCH-IV; March4; Marchf4; mKIAA1399", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF4; 2.3.2.27; MARCH-IV; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; RING-type E3 ubiquitin transferase MARCHF4", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase MARCHF4 isoform 1 precursor; E3 ubiquitin-protein ligase MARCHF4; RING-type E3 ubiquitin transferase MARCH4; RING-type E3 ubiquitin transferase MARCHF4; membrane-associated RING finger protein 4; membrane-associated RING-CH protein IV; membrane-associated ring finger (C3HC4) 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:381270)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQN4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80TE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80US8-1", "uniprot_id": "MAD3_MOUSE", "mass": 23635.0, "length": 206, "protein_name": "Max dimerization protein 3", "gene_name": "Mxd3", "organism": "Mouse", "refseq_name": "max dimerization protein 3", "refseq_ac": "NP_057871", "gene_names_uniprotkb": "Mxd3; Mad3", "gene_names_refseq": "4631412E13Rik; Mad3; Mxd3; bHLHc13", "protein_names_uniprotkb": "Max dimerization protein 3; Max dimerizer 3; Max-associated protein 3", "protein_names_refseq": "max dimerization protein 3; max dimerizer 3; max-associated protein 3", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:17121)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10597267;11154258;35820727;8521822", "class_list": "", "function": "Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60947", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80US8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X72-1", "uniprot_id": "LRC15_MOUSE", "mass": 64177.0, "length": 579, "protein_name": "Leucine-rich repeat-containing protein 15", "gene_name": "Lrrc15", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 15 precursor", "refseq_ac": "NP_083249", "gene_names_uniprotkb": "Lrrc15", "gene_names_refseq": "5430427N11Rik; LIB; Lrrc15", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 15", "protein_names_refseq": "leucine-rich repeat-containing protein 15 precursor; leucine-rich repeat-containing protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:74488)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;25428506;34428180;34702854;35820727;38566328;38763774", "class_list": "", "function": "Effect of LRRC15 on autophagy in A549 cells., [RefSeq, PubMed]; Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0001968 fibronectin binding;GO:0038023 signaling receptor activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045211 postsynaptic membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0051965 positive regulation of synapse assembly;GO:0046813 receptor-mediated virion attachment to host cell;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0046597 host-mediated suppression of symbiont invasion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80X72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGY3-1", "uniprot_id": "LUZP2_MOUSE", "mass": 39020.0, "length": 345, "protein_name": "Leucine zipper protein 2", "gene_name": "Luzp2", "organism": "Mouse", "refseq_name": "leucine zipper protein 2 precursor", "refseq_ac": "NP_848820", "gene_names_uniprotkb": "Luzp2", "gene_names_refseq": "9330154K17Rik; D130073E01; Luzp2", "protein_names_uniprotkb": "Leucine zipper protein 2", "protein_names_refseq": "leucine zipper motif 2; leucine zipper protein 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:233271)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12856284;16280085;30899004", "class_list": "", "function": "Mapping of Chrna7 and Luzp2 neuronal transcriptional enhancers in a mouse model of Prader-Willi and Angelman syndromes Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPB5;Q8CBZ7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BGY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BL03-1", "uniprot_id": "S2529_MOUSE", "mass": 32672.0, "length": 306, "protein_name": "Mitochondrial basic amino acids transporter", "gene_name": "Slc25a29", "organism": "Mouse", "refseq_name": "mitochondrial basic amino acids transporter", "refseq_ac": "NP_851845", "gene_names_uniprotkb": "Slc25a29; Ornt3", "gene_names_refseq": "C030003J19Rik; CACL; Slc25a29; mCACL", "protein_names_uniprotkb": "Mitochondrial basic amino acids transporter; CACT-like; Carnitine/acylcarnitine translocase-like; Mitochondrial carnitine/acylcarnitine carrier protein CACL; Mitochondrial ornithine transporter 3; Solute carrier family 25 member 29", "protein_names_refseq": "carnitine/acylcarnitine translocase-like; mitochondrial basic amino acids transporter; mitochondrial carnitine/acylcarnitine carrier protein CACL; mitochondrial ornithine transporter 3; solute carrier family 25 member 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:214663); (R-MMU-352230)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12882971;19287344", "class_list": "", "function": "Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine (By similarity). Transports with a much lesser extent, ornithine and histidine (PubMed:19287344). Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Plays a physiological role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation (By similarity)., [UniProtKB, UniProtKB, PubMed]; The human and mouse SLC25A29 mitochondrial ornithine transporters (designated as ORNT3) rescue the deficient ornithine metabolism in fibroblasts of patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q922X4", "ec_number_list": "", "go_molecular_function": "GO:0005289 high-affinity L-arginine transmembrane transporter activity;GO:0005292 high-affinity lysine transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0015227 O-acyl-L-carnitine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015822 ornithine transport;GO:0089709 L-histidine transmembrane transport;GO:1903401 L-lysine transmembrane transport;GO:1990575 mitochondrial L-ornithine transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BL03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLG2-1", "uniprot_id": "LPAR4_MOUSE", "mass": 41899.0, "length": 370, "protein_name": "Lysophosphatidic acid receptor 4", "gene_name": "Lpar4", "organism": "Mouse", "refseq_name": "lysophosphatidic acid receptor 4", "refseq_ac": "NP_780480", "gene_names_uniprotkb": "Lpar4; Gpr23; Lpa4; P2y9", "gene_names_refseq": "5730485F04Rik; Gpr23; LPA4; Lpar4; p2y9", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 4; G protein-coupled receptor 23; LPA receptor 4; LPA-4; P2Y purinoceptor 9; P2Y9; Purinergic receptor 9", "protein_names_refseq": "G protein-coupled receptor 23; LPA receptor 4; LPA-4; P2Y purinoceptor 9; lysophosphatidic acid receptor 4; purinergic receptor 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:78134); (R-MMU-416476); (R-MMU-417957)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18625716;31599954", "class_list": "", "function": "Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13., [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2ADM5;Q8BKK1;Q8VE54", "ec_number_list": "", "go_molecular_function": "GO:0070915 lysophosphatidic acid receptor activity;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BLG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM14-1", "uniprot_id": "LIPK_MOUSE", "mass": 45243.0, "length": 398, "protein_name": "Lipase member K", "gene_name": "Lipk", "organism": "Mouse", "refseq_name": "lipase member K isoform 1 precursor", "refseq_ac": "NP_001192278", "gene_names_uniprotkb": "Lipk; Lipl2", "gene_names_refseq": "9930115F20; Lipk; Lipl2", "protein_names_uniprotkb": "Lipase member K; 3.1.1.-; Lipase-like abhydrolase domain-containing protein 2", "protein_names_refseq": "lipase member K isoform 1 precursor; lipase member K; lipase-like abhydrolase domain-containing protein 2; lipase-like, ab-hydrolase domain containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:240633); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TML7", "ec_number_list": "3.1.1.13;3.1.1.3;3.1.1.-", "go_molecular_function": "GO:0016298 lipase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BM14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ81-1", "uniprot_id": "LRRT3_MOUSE", "mass": 66088.0, "length": 582, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 3", "gene_name": "Lrrtm3", "organism": "Mouse", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 3 precursor", "refseq_ac": "NP_848793", "gene_names_uniprotkb": "Lrrtm3", "gene_names_refseq": "9630044H04Rik; Lrrtm3", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 3", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 3 precursor; leucine-rich repeat transmembrane neuronal protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:216028); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12676565;26776509;33300544;35022233", "class_list": "", "function": "LRRTM3 is required for dentate gyrus excitatory synapse development and regulates activity-dependent AMPAR surface expression., [RefSeq, PubMed]; LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits., [RefSeq, PubMed]; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14CH3;Q3TQA3;Q8BGJ7", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:1902004 positive regulation of amyloid-beta formation;GO:0051965 positive regulation of synapse assembly;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BZ81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBH7-1", "uniprot_id": "MARHB_MOUSE", "mass": 44223.0, "length": 400, "protein_name": "E3 ubiquitin-protein ligase MARCHF11", "gene_name": "Marchf11", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF11 isoform 2", "refseq_ac": "NP_001297703", "gene_names_uniprotkb": "Marchf11; March11", "gene_names_refseq": "9630025C22; March11; Marchf11", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF11; 2.3.2.27; MARCH-XI; Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI; RING-type E3 ubiquitin transferase MARCHF11", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH11; E3 ubiquitin-protein ligase MARCHF11 isoform 2; E3 ubiquitin-protein ligase MARCHF11; MARCH-XI; RING-type E3 ubiquitin transferase MARCH11; RING-type E3 ubiquitin transferase MARCHF11; membrane-associated RING finger protein 11; membrane-associated RING-CH protein XI; membrane-associated ring finger (C3HC4) 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:211147)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22075566", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids., [UniProtKB, UniProtKB]; Results suggest that SAMT1 proteins are physiological substrates of MARCH11 and are delivered to lysosomes through the TGN-MVB pathway by a ubiquitin-dependent sorting system in mouse spermatids, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EIG0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CBH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1T4-1", "uniprot_id": "LY65B_MOUSE", "mass": 21615.0, "length": 194, "protein_name": "Lymphocyte antigen 6 complex locus protein G5b", "gene_name": "Ly6g5b", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6 complex locus protein G5b isoform 1 precursor", "refseq_ac": "NP_683741", "gene_names_uniprotkb": "Ly6g5b", "gene_names_refseq": "Ly6g5b", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G5b", "protein_names_refseq": "lymphocyte antigen 6 complex locus protein G5b isoform 1 precursor; lymphocyte antigen 6 complex locus protein G5b; lymphocyte antigen 6 complex, locus G5B", "tax_id": 10090, "disease": "", "pathway": " (mmu:266614)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12079290;17008713;36428102", "class_list": "", "function": "CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U982", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K1T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1T5-1", "uniprot_id": "LY65C_MOUSE", "mass": 16590.0, "length": 149, "protein_name": "Lymphocyte antigen 6 complex locus protein G5c", "gene_name": "Ly6g5c", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6 complex locus protein G5c precursor", "refseq_ac": "NP_683749", "gene_names_uniprotkb": "Ly6g5c", "gene_names_refseq": "G5c; Ly6g5c; NG33", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G5c", "protein_names_refseq": "lymphocyte antigen 6 complex locus protein G5c precursor; lymphocyte antigen 6 complex locus protein G5c; lymphocyte antigen 6 complex, locus G5C", "tax_id": 10090, "disease": "", "pathway": " (mmu:114652)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12079290;17008713;36428102", "class_list": "", "function": "CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice., [RefSeq, PubMed]; May have a role in hematopoietic cell differentiation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0D2G4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K1T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R033-1", "uniprot_id": "LYRM2_MOUSE", "mass": 10380.0, "length": 88, "protein_name": "LYR motif-containing protein 2", "gene_name": "Lyrm2", "organism": "Mouse", "refseq_name": "LYR motif-containing protein 2", "refseq_ac": "NP_780573", "gene_names_uniprotkb": "Lyrm2", "gene_names_refseq": "2610208E05Rik; Lyrm2", "protein_names_uniprotkb": "LYR motif-containing protein 2", "protein_names_refseq": "LYR motif-containing protein 2; novel complex 1 (LYR family) protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:108755); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANY7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8R033-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XL2-1", "uniprot_id": "LNX2_MOUSE", "mass": 75129.0, "length": 687, "protein_name": "Ligand of Numb protein X 2", "gene_name": "Lnx2", "organism": "Mouse", "refseq_name": "ligand of Numb protein X 2", "refseq_ac": "NP_542985", "gene_names_uniprotkb": "Lnx2", "gene_names_refseq": "9630046H24; Lnx2", "protein_names_uniprotkb": "Ligand of Numb protein X 2; Numb-binding protein 2", "protein_names_refseq": "ligand of Numb protein X 2; numb-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:140887)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11922143;15979067;25279559;34428180;36674899", "class_list": "", "function": "Caspr4 inhibits neuronal differentiation in a LNX-dependent manner., [RefSeq, PubMed]; Coxsackievirus and adenovirus receptor is a partner in a protein complex organized at specific subcellular sites by LNX2, [RefSeq, PubMed]; Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6PW04;Q8CBE1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030182 neuron differentiation;GO:0061351 neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91XL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YK8-1", "uniprot_id": "LYPD3_MOUSE", "mass": 37489.0, "length": 363, "protein_name": "Ly6/PLAUR domain-containing protein 3", "gene_name": "Lypd3", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 3 precursor", "refseq_ac": "NP_598504", "gene_names_uniprotkb": "Lypd3; C4.4a", "gene_names_refseq": "2310061G07Rik; C4.4a; Lypd3", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein C4.4A homolog", "protein_names_refseq": "GPI-anchored metastasis-associated protein C4.4A homolog; GPI-anchored metastasis-associated protein homolog; ly6/PLAUR domain-containing protein 3 precursor; ly6/PLAUR domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72434); (R-MMU-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15012588;21339181;27169360;29075641", "class_list": "", "function": "A possible functional role of C4.4A in early differentiation of stratified squamous epithelia, [RefSeq, PubMed]; Our results are consistent with previous data in mouse embryogenesis and wound healing. Based on these findings, we conclude that this human TES model provides an excellent surrogate for studies of C4.4A and Haldisin expressions in human stratified epithelia., [RefSeq, PubMed]; Supports cell migration. May be involved in tumor progression (By similarity)., [UniProtKB]; The first C4.4A-deficient mouse line was characterized to gain insight into the functional significance of C4.4A in normal physiology and cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043236 laminin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0034392 negative regulation of smooth muscle cell apoptotic process;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91YK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924L1-1", "uniprot_id": "LTMD1_MOUSE", "mass": 41701.0, "length": 360, "protein_name": "LETM1 domain-containing protein 1", "gene_name": "Letmd1", "organism": "Mouse", "refseq_name": "LETM1 domain-containing protein 1 isoform 1", "refseq_ac": "NP_598854", "gene_names_uniprotkb": "Letmd1; Mccr", "gene_names_refseq": "1110019O13Rik; HCCR-2; HCCR1; Letmd1; MCC-32; Mccr", "protein_names_uniprotkb": "LETM1 domain-containing protein 1; Cervical cancer receptor; MCC-32", "protein_names_refseq": "LETM1 domain-containing protein 1 isoform 1; LETM1 domain-containing protein 1; cervical cancer receptor", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); uterine cancer (Disease Ontology:DOID:363); ovarian carcinoma (Disease Ontology:DOID:4001); renal carcinoma (Disease Ontology:DOID:4451); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (mmu:68614)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12879013;16949218;20196787;21183079;21750661;34428180;34669999;34910916;36210013;36334589;37353518;37769890", "class_list": "", "function": "HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE, [RefSeq, PubMed]; LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis., [RefSeq, PubMed]; Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes (PubMed:34669999, PubMed:34910916, PubMed:36334589). In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (PubMed:34910916). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The level of HCCR-1 expression was increased during the mouse embryogenesis and expression of phosphatidylinositol 3-kinase (PI3K) in NIH/3T3 cells activated the HCCR-1 promoter., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF05;Q3U3M7;Q8BLG9;Q8K1F7;Q8VDS9", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:1903409 reactive oxygen species biosynthetic process;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0006754 ATP biosynthetic process;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q924L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KE1-1", "uniprot_id": "MAOM_MOUSE", "mass": 65799.0, "length": 589, "protein_name": "NAD-dependent malic enzyme, mitochondrial", "gene_name": "Me2", "organism": "Mouse", "refseq_name": "NAD-dependent malic enzyme, mitochondrial precursor", "refseq_ac": "NP_663469", "gene_names_uniprotkb": "Me2", "gene_names_refseq": "D030040L20Rik; Me2; NAD-ME", "protein_names_uniprotkb": "NAD-dependent malic enzyme, mitochondrial; 1.1.1.38; Malic enzyme 2; NAD-ME", "protein_names_refseq": "NAD-dependent malic enzyme, mitochondrial precursor; NAD-dependent malic enzyme, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:107029); (R-MMU-70268); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "19691144;22645316;23334421;26495903;28099419;28528544;30084848;31219806;32152506;33770508;34428180;37087800;37253016", "class_list": "", "function": "Cellular redox homeostasis maintained by malic enzyme 2 is essential for MYC-driven T cell lymphomagenesis., [RefSeq, PubMed]; Deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer, [RefSeq, PubMed]; Inhibition of miR-214-3p attenuates ferroptosis in myocardial infarction via regulating ME2., [RefSeq, PubMed]; Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis., [RefSeq, PubMed]; Me2 activity in Islet of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties of Me2., [RefSeq, PubMed]; NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate., [UniProtKB, UniProtKB]; P53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBM8", "ec_number_list": "3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;3.1.2.-;3.1.2.2;3.4.21.92;1.1.1.40;1.1.1.37;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;1.1.1.42;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;1.1.1.30;2.7.11.2;6.1.1.5;2.7.1.23;3.4.21.53;5.6.2.3;2.3.1.9;3.7.1.5;4.1.1.112;5.3.2.2;2.3.1.37;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;1.3.8.1;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0046872 metal ion binding;GO:0051287 NAD binding;GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004470 malic enzyme activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006108 malate metabolic process;GO:1902031 regulation of NADP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99KE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N05-1", "uniprot_id": "M4A4D_MOUSE", "mass": 23859.0, "length": 225, "protein_name": "Membrane-spanning 4-domains subfamily A member 4D", "gene_name": "Ms4a4d", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 4D", "refseq_ac": "NP_079934", "gene_names_uniprotkb": "Ms4a4d", "gene_names_refseq": "2210417J23Rik; Ms4a4d", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 4D", "protein_names_refseq": "membrane-spanning 4-domains subfamily A member 4D", "tax_id": 10090, "disease": "", "pathway": " (mmu:66607)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11401424;25428506;31219806", "class_list": "", "function": "May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N07-1", "uniprot_id": "M4A6D_MOUSE", "mass": 26383.0, "length": 247, "protein_name": "Membrane-spanning 4-domains subfamily A member 6D", "gene_name": "Ms4a6d", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 6D", "refseq_ac": "NP_081111", "gene_names_uniprotkb": "Ms4a6d; Cd20l8; Ms4a11", "gene_names_refseq": "1110058E16Rik; Ms4a11; Ms4a6d", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 6D; CD20 antigen-like 8", "protein_names_refseq": "CD20 antigen-like 8; membrane-spanning 4-domains subfamily A member 6D; membrane-spanning 4-domains, subfamily A, member 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:68774)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11245982;11401424;21183079;21750661;25428506;25605945;34428180;37429063;38493579", "class_list": "", "function": "MS4A6D Promotes carrageenan-induced footpad swelling in mice through enhancing macrophages-derived inflammation., [RefSeq, PubMed]; May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]; Tetraspan MS4A6D is a coreceptor of MHC class II antigen (MHC-II) that promotes macrophages-derived inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0X1;Q9EQY7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99N07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N09-1", "uniprot_id": "M4A6B_MOUSE", "mass": 26860.0, "length": 244, "protein_name": "Membrane-spanning 4-domains subfamily A member 6B", "gene_name": "Ms4a6b", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 6B", "refseq_ac": "NP_081485", "gene_names_uniprotkb": "Ms4a6b", "gene_names_refseq": "1810027D10Rik; Ms4a6b", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 6B", "protein_names_refseq": "membrane-spanning 4-domains subfamily A member 6B", "tax_id": 10090, "disease": "", "pathway": " (mmu:69774)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11401424;21750661;26495903", "class_list": "", "function": "May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK83;Q9D8W9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ07-1", "uniprot_id": "LRC18_MOUSE", "mass": 29520.0, "length": 262, "protein_name": "Leucine-rich repeat-containing protein 18", "gene_name": "Lrrc18", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 18 isoform 2", "refseq_ac": "NP_001139493", "gene_names_uniprotkb": "Lrrc18; Mtlr1", "gene_names_refseq": "4930442L21Rik; Lrrc18; MTLR1", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 18; Testis-specific LRR protein", "protein_names_refseq": "leucine-rich repeat-containing protein 18 isoform 2; leucine-rich repeat-containing protein 18; testis-specific LRR protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67580)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15707978;21750661", "class_list": "", "function": "May be involved in the regulation of spermatogenesis and sperm maturation., [UniProtKB, UniProtKB, UniProtKB]; The time-dependent expression pattern of mtLR1 in postnatal mouse testes suggested that mtLR1 gene might be involved in the regulation of spermatogenesis and sperm maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8T8;Q80ZT3;Q9CW01;Q9DA89", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQ07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ21-1", "uniprot_id": "MCTS2_MOUSE", "mass": 20437.0, "length": 181, "protein_name": "Malignant T-cell-amplified sequence 2", "gene_name": "Mcts2", "organism": "Mouse", "refseq_name": "malignant T-cell-amplified sequence 2", "refseq_ac": "NP_079819", "gene_names_uniprotkb": "Mcts2", "gene_names_refseq": "2400002F11Rik; MCT-2; Mcts2", "protein_names_uniprotkb": "Malignant T-cell-amplified sequence 2; MCT-2; Multiple copies T-cell malignancies 2", "protein_names_refseq": "malignant T-cell-amplified sequence 2; multiple copies T-cell malignancies 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66405)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18024232;25428506;30084848;30779550;32152506;33649389;34428180;35820727;35984892;36210013;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0002188 translation reinitiation;GO:0006351 DNA-templated transcription;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQ21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQB7-1", "uniprot_id": "LYRM1_MOUSE", "mass": 14224.0, "length": 122, "protein_name": "LYR motif-containing protein 1", "gene_name": "Lyrm1", "organism": "Mouse", "refseq_name": "LYR motif-containing protein 1", "refseq_ac": "NP_001272888", "gene_names_uniprotkb": "Lyrm1", "gene_names_refseq": "1110065L10Rik; 2310004B22Rik; 4930404J24Rik; Lyrm1", "protein_names_uniprotkb": "LYR motif-containing protein 1", "protein_names_refseq": "LYR motif-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73919)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22110480;22249831;22820890;24771405;26759027", "class_list": "", "function": "Alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt., [RefSeq, PubMed]; FCCP-induced mitochondrial dysfunction and insulin resistance are ameliorated by knockdown of LYRM1, [RefSeq, PubMed]; Knockdown of LYRM1 induced mitochondrial impairment in P19 cells during differentiation, which was reflected by decreased ATP synthesis, lower MMP and increased ROS levels., [RefSeq, PubMed]; Knockdown of the Lyrm1 gene in adipocytes resulted in dramatically increased cellular ATP production, mitochondrial membrane potentials and levels Ucp2 mRNA, while ROS levels were significantly decreased., [RefSeq, PubMed]; May promote cell proliferation and inhibition of apoptosis of preadipocytes., [UniProtKB]; Results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity; LYRM1 may be an important mediator in the development of obesity-related insulin resistance, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZE0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0030496 midbody", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWV4-1", "uniprot_id": "MAGBG_MOUSE", "mass": 40893.0, "length": 363, "protein_name": "Melanoma-associated antigen B16", "gene_name": "Mageb16", "organism": "Mouse", "refseq_name": "melanoma-associated antigen B16", "refseq_ac": "NP_001107206", "gene_names_uniprotkb": "Mageb16", "gene_names_refseq": "2410003J06Rik; Mageb16", "protein_names_uniprotkb": "Melanoma-associated antigen B16; MAGE-B16 antigen", "protein_names_refseq": "MAGE-B16 antigen; Novel MAGE family protein; melanoma antigen family B, 16; melanoma-associated antigen B16", "tax_id": 10090, "disease": "", "pathway": " (mmu:71967)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29079788", "class_list": "", "function": "Mageb16 (41 kDa) is distributed in cytosol and/or in surface membrane in undifferentiated murine embryonic stem cells (ESCs). A transcriptome study performed at differentiated short hairpin RNA (shRNA)-mediated Mageb16 knockdown (KD) ESCs and scrambled control ESCs until a period of 22 days, revealed that Mageb16 KD ESCs mainly differentiated towards cells expressing mesodermal and cardiovascular lineage - gene markers. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJP9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXD9-1", "uniprot_id": "LRC17_MOUSE", "mass": 51852.0, "length": 443, "protein_name": "Leucine-rich repeat-containing protein 17", "gene_name": "Lrrc17", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 17 precursor", "refseq_ac": "NP_083253", "gene_names_uniprotkb": "Lrrc17", "gene_names_refseq": "37kDa; 4833425M04Rik; 6130400C22Rik; Lrrc17; P37nb", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 17", "protein_names_refseq": "37 kDa leucine-rich repeat (LRR) protein; leucine-rich repeat (LRR) protein; leucine-rich repeat-containing protein 17 precursor; leucine-rich repeat-containing protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:74511)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19336404;33865167", "class_list": "", "function": "Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors., [UniProtKB, PubMed]; LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss., [RefSeq, PubMed]; These results demonstrated a novel inhibitory activity of LRRc17 in RANKL-induced osteoclastogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0001503 ossification;GO:0045671 negative regulation of osteoclast differentiation;GO:0048539 bone marrow development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9Q0-1", "uniprot_id": "LRC69_MOUSE", "mass": 40066.0, "length": 347, "protein_name": "Leucine-rich repeat-containing protein 69", "gene_name": "Lrrc69", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 69", "refseq_ac": "NP_082775", "gene_names_uniprotkb": "Lrrc69", "gene_names_refseq": "1700034K16Rik; Lrrc69", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 69", "protein_names_refseq": "leucine-rich repeat-containing protein 69", "tax_id": 10090, "disease": "", "pathway": " (mmu:73314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D9Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ31-1", "uniprot_id": "LPAR3_MOUSE", "mass": 40316.0, "length": 354, "protein_name": "Lysophosphatidic acid receptor 3", "gene_name": "Lpar3", "organism": "Mouse", "refseq_name": "lysophosphatidic acid receptor 3", "refseq_ac": "NP_075359", "gene_names_uniprotkb": "Lpar3; Edg7; Lpa3", "gene_names_refseq": "Edg7; Lpar3; lpA3", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 3; LPA receptor 3; LPA-3; Lysophosphatidic acid receptor Edg-7", "protein_names_refseq": "LPA receptor 3; LPA-3; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7; lysophosphatidic acid receptor 3; lysophosphatidic acid receptor Edg-7", "tax_id": 10090, "disease": "", "pathway": " (mmu:65086); (R-MMU-416476); (R-MMU-418594); (R-MMU-419408)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11313151;22299025;25428506;35820727;36088312", "class_list": "", "function": "Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005543 phospholipid binding;GO:0001965 G-protein alpha-subunit binding;GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030424 axon", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0032060 bleb assembly;GO:0051928 positive regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQ31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXA5-1", "uniprot_id": "LSM4_MOUSE", "mass": 15076.0, "length": 137, "protein_name": "U6 snRNA-associated Sm-like protein LSm4", "gene_name": "Lsm4", "organism": "Mouse", "refseq_name": "U6 snRNA-associated Sm-like protein LSm4 isoform 1", "refseq_ac": "NP_056631", "gene_names_uniprotkb": "Lsm4; LSM4", "gene_names_refseq": "Lsm4", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm4", "protein_names_refseq": "LSM4 homolog, U6 small nuclear RNA associated; U6 snRNA-associated SM-like protein 4; U6 snRNA-associated Sm-like protein LSm4 isoform 1; U6 snRNA-associated Sm-like protein LSm4", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (mmu:50783); (R-MMU-430039); (R-MMU-72163)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10629062;21750661;30084848", "class_list": "", "function": "Binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB]; Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042731 PH domain binding;GO:0017070 U6 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0033962 P-body assembly;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QXA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU40-1", "uniprot_id": "MAN1_MOUSE", "mass": 100307.0, "length": 921, "protein_name": "Inner nuclear membrane protein Man1", "gene_name": "Lemd3", "organism": "Mouse", "refseq_name": "inner nuclear membrane protein Man1", "refseq_ac": "NP_001074662", "gene_names_uniprotkb": "Lemd3; Man1", "gene_names_refseq": "Lemd3; Man1", "protein_names_uniprotkb": "Inner nuclear membrane protein Man1; LEM domain-containing protein 3", "protein_names_refseq": "LEM domain-containing protein 3; inner nuclear membrane protein Man1; integral inner nuclear membrane protein MAN1", "tax_id": 10090, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); cataract 46 juvenile-onset (Disease Ontology:DOID:0110243); Buschke-Ollendorff syndrome (Disease Ontology:DOID:0111536); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (mmu:380664)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10671519;16452087;16943282;17242355;18697220;19862465;21183079;21750661;22872234;23779087;25428506;28135057;28528544;30084848;31219806;34428180;35820727;36852467;40997131", "class_list": "", "function": "A nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A. Publication Status: Online-Only, [RefSeq, PubMed]; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In Man1-deficient embryos, the expression of Tgfb1 is upregulated and Smad2/3 signaling is abnormally activated, resulting in increased extracellular matrix deposition, a hallmark of the resolution phase of angiogenesis., [RefSeq, PubMed]; Man1 regulates left-right asymmetry by controlling Nodal signaling in a node-independent manner, [RefSeq, PubMed]; The heterozygous Lemd3 gene-trapped mouse is not a good model to study osteopoikilosis and the Buschke-Ollendorff syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGU6;Q3USB5", "ec_number_list": "", "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0002044 blood vessel endothelial cell migration involved in intussusceptive angiogenesis;GO:0001525 angiogenesis;GO:0030514 negative regulation of BMP signaling pathway;GO:1903053 regulation of extracellular matrix organization;GO:0032926 negative regulation of activin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q9WU40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU67-1", "uniprot_id": "LY6I_MOUSE", "mass": 14714.0, "length": 134, "protein_name": "Lymphocyte antigen 6I", "gene_name": "Ly6i", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6I precursor", "refseq_ac": "NP_065244", "gene_names_uniprotkb": "Ly6i; Ly6m", "gene_names_refseq": "Ly-6I; Ly-6M; Ly6i", "protein_names_uniprotkb": "Lymphocyte antigen 6I; Ly-6I; Ly-6M; Lymphocyte antigen 6M", "protein_names_refseq": "lymphocyte antigen 6 complex, locus I; lymphocyte antigen 6I precursor; lymphocyte antigen 6I; lymphocyte antigen 6M", "tax_id": 10090, "disease": "", "pathway": " (mmu:57248)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10807778;10861067", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05AA4", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WU67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CE94-1", "uniprot_id": "MOT13_MOUSE", "mass": 44862.0, "length": 428, "protein_name": "Monocarboxylate transporter 13", "gene_name": "Slc16a13", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 13", "refseq_ac": "NP_758959", "gene_names_uniprotkb": "Slc16a13; Mct13", "gene_names_refseq": "1700007D07Rik; Slc16a13", "protein_names_uniprotkb": "Monocarboxylate transporter 13; MCT 13; Solute carrier family 16 member 13", "protein_names_refseq": "MCT 13; monocarboxylate transporter 13; solute carrier family 16 member 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:69309)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17978498;21750661;31219806;34211098;34428180;36210013", "class_list": "", "function": "Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Erratum:[Commun Biol. 2021 Jul 14;4(1):890. doi: 10.1038/s42003-021-02425-2. PMID: 34262128] Publication Status: Online-Only, [RefSeq, PubMed]; PPARalpha up-regulates the expression of Slc16a13 in small intestine., [RefSeq, PubMed]; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEH6;Q8CF46", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CE94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UG61-1", "uniprot_id": "MRGB1_MOUSE", "mass": 40161.0, "length": 350, "protein_name": "Mas-related G protein-coupled receptor member B1", "gene_name": "Mrgprb1", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member B1", "refseq_ac": "NP_991379", "gene_names_uniprotkb": "Mrgprb1; Mrgb1", "gene_names_refseq": "MrgB1; Mrgprb1", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B1", "protein_names_refseq": "MrgB1 G protein-coupled receptor; mas-related G-protein coupled receptor member B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233231)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11551509;21750661;30084848;31219806;34428180", "class_list": "", "function": "Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4FUT5;A4QMY7;Q3UFN5;Q3UFT1;Q3UFW7;Q3UFX0;Q3UFX7;Q3UFY5;Q3UG23;Q3UG95;Q91ZC3", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0045576 mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UG61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G5E8K6-1", "uniprot_id": "MOT6_MOUSE", "mass": 51018.0, "length": 468, "protein_name": "Monocarboxylate transporter 6", "gene_name": "Slc16a5", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 6 isoform 1", "refseq_ac": "NP_001074403", "gene_names_uniprotkb": "Slc16a5; Mct5; Mct6", "gene_names_refseq": "A130015N09Rik; MCT 5; MCT 6; MCT5; Slc16a5", "protein_names_uniprotkb": "Monocarboxylate transporter 6; MCT 5; MCT 6; Monocarboxylate transporter 5; Solute carrier family 16 member 5", "protein_names_refseq": "monocarboxylate transporter 5; monocarboxylate transporter 6 isoform 1; monocarboxylate transporter 6; solute carrier family 16 member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:217316)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9X8;A2A9X9;A2A9Y0", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G5E8K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7BJB9-1", "uniprot_id": "MORC3_MOUSE", "mass": 106522.0, "length": 942, "protein_name": "MORC family CW-type zinc finger protein 3", "gene_name": "Morc3", "organism": "Mouse", "refseq_name": "MORC family CW-type zinc finger protein 3", "refseq_ac": "NP_001038994", "gene_names_uniprotkb": "Morc3; Nxp2; Zcwcc3", "gene_names_refseq": "1110051N18Rik; D16Jhu32e; Morc3; NXP2; Zcwcc3", "protein_names_uniprotkb": "MORC family CW-type zinc finger protein 3; Nuclear matrix protein 2; Zinc finger CW-type coiled-coil domain protein 3", "protein_names_refseq": "MORC family CW-type zinc finger protein 3; nuclear matrix protein 2; zinc finger CW-type coiled-coil domain protein 3; zinc finger, CW-type with coiled-coil domain 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:338467)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17332504;21183079;21750661;27188231;27528681;34428180;34706774;36852467;39627609", "class_list": "", "function": "Data show that the MORC3 N-terminal ATPase domain forms a dimer when bound to AMPPNP., [RefSeq, PubMed]; Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0., [UniProtKB, UniProtKB, PubMed]; The role of MORC3 in silencing transposable elements in mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H605;Q4QQR6;Q6A0C2;Q8R0R0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016363 nuclear matrix;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0060337 type I interferon-mediated signaling pathway;GO:0050821 protein stabilization;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "F7BJB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUM7-1", "uniprot_id": "MSH5_MOUSE", "mass": 92602.0, "length": 833, "protein_name": "MutS protein homolog 5", "gene_name": "Msh5", "organism": "Mouse", "refseq_name": "mutS protein homolog 5", "refseq_ac": "NP_001139687", "gene_names_uniprotkb": "Msh5", "gene_names_refseq": "Msh5; Mut5", "protein_names_uniprotkb": "MutS protein homolog 5", "protein_names_refseq": "DNA mismatch repair protein Msh5; mutS protein homolog 5", "tax_id": 10090, "disease": "spermatogenic failure 74 (Disease Ontology:DOID:0070573); primary ovarian insufficiency 13 (Disease Ontology:DOID:0080870); lung non-small cell carcinoma (Disease Ontology:DOID:3908); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:17687)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10556423;11797099;14656967;21750661;28175301;34980881;37612290;9916805", "class_list": "", "function": "Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the MutS family of proteins that play critical roles in DNA mismatch repair and meiotic homologous recombination processes. Mice lacking the encoded protein are viable but sterile, with severe defects in spermatogenesis in males and complete loss of ovarian structures in females. Mutations in a similar gene in humans have been shown to cause common variable immune deficiency (CVID) and immunoglobulin A deficiency. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1Q6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003690 double-stranded DNA binding;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990391 DNA repair complex;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0007129 homologous chromosome pairing at meiosis;GO:0007292 female gamete generation;GO:0051026 chiasma assembly;GO:0007127 meiosis I", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QUM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZB5-1", "uniprot_id": "MRGRG_MOUSE", "mass": 32028.0, "length": 289, "protein_name": "Mas-related G protein-coupled receptor member G", "gene_name": "Mrgprg", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member G", "refseq_ac": "NP_987077", "gene_names_uniprotkb": "Mrgprg; Ebrt2; Gm1098; Mrgg", "gene_names_refseq": "Gm1098; Mrgg; Mrgprg", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member G; Evolutionary breakpoint transcript 2 protein", "protein_names_refseq": "G protein-coupled receptor MrgG; evolutionary breakpoint transcript 2 protein; mas-related G-protein coupled receptor member G", "tax_id": 10090, "disease": "", "pathway": " (mmu:381974)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11551509;21750661", "class_list": "", "function": "Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498A2;Q711N2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91ZB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2R6-1", "uniprot_id": "MTG1_MOUSE", "mass": 36679.0, "length": 326, "protein_name": "Mitochondrial ribosome-associated GTPase 1", "gene_name": "Mtg1", "organism": "Mouse", "refseq_name": "mitochondrial ribosome-associated GTPase 1", "refseq_ac": "NP_955005", "gene_names_uniprotkb": "Mtg1; Gm169; Gtpbp7", "gene_names_refseq": "Gm169; Gtpbp7; Mtg1", "protein_names_uniprotkb": "Mitochondrial ribosome-associated GTPase 1; GTP-binding protein 7; Mitochondrial GTPase 1", "protein_names_refseq": "GTP binding protein 7 (putative); GTP-binding protein 7; mitochondrial GTPase 1 homolog; mitochondrial ribosome-associated GTPase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212508)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30707992", "class_list": "", "function": "Dampening oxidative stress with N-acetylcysteine (NAC) lowered hypertrophy in MTG1 KO to WT levels. Collectively, our data indicate that MTG1 protects against pressure overload-induced cardiac hypertrophy and dysfunction by preserving mitochondrial function and reducing oxidative stress and downstream TAK1 stress signaling., [RefSeq, PubMed]; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMX2;Q3UN50", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0070129 regulation of mitochondrial translation;GO:0044065 regulation of respiratory system process;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R2R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1S7-1", "uniprot_id": "MRP6_MOUSE", "mass": 164857.0, "length": 1498, "protein_name": "ATP-binding cassette sub-family C member 6", "gene_name": "Abcc6", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 6", "refseq_ac": "NP_061265", "gene_names_uniprotkb": "Abcc6; Mrp6", "gene_names_refseq": "Abcc1b; Abcc6; DCC; Dyscalc1; Mrp6; dyscalc", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 6; 7.6.2.-; 7.6.2.3; Multidrug resistance-associated protein 6", "protein_names_refseq": "ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; multidrug resistance-associated protein 6", "tax_id": 10090, "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:27421); (R-MMU-382556)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15888484;17242355;17360558;21750661;23625951;24277820;25428506;30084848;31219806;34428180;38057332;38367909", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB]; Abcc6 deficiency prevents rhabdomyolysis-induced acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; Bone Marrow-Derived ABCC6 Is an Essential Regulator of Ectopic Calcification In Pseudoxanthoma Elasticum., [RefSeq, PubMed]; Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein is unknown; however, a similar rat protein has been identified as the major canalicular bile salt export pump of liver. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2TAJ0;A2TAJ1;F8VPT2;Q80YB6", "ec_number_list": "7.6.2.2;7.6.2.-;7.6.2.3;5.6.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:1904383 response to sodium phosphate;GO:0055085 transmembrane transport;GO:0006855 xenobiotic transmembrane transport;GO:0055062 phosphate ion homeostasis;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R1S7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02802-1", "uniprot_id": "MT1_MOUSE", "mass": 6018.0, "length": 61, "protein_name": "Metallothionein-1", "gene_name": "Mt1", "organism": "Mouse", "refseq_name": "metallothionein-1", "refseq_ac": "NP_038630", "gene_names_uniprotkb": "Mt1", "gene_names_refseq": "MT-I; Mt-1; Mt1", "protein_names_uniprotkb": "Metallothionein-1; MT-1; MT-I; Metallothionein-I", "protein_names_refseq": "metallothionein-1; metallothionein-I", "tax_id": 10090, "disease": "kidney failure (Disease Ontology:DOID:1074); transient cerebral ischemia (Disease Ontology:DOID:224); median neuropathy (Disease Ontology:DOID:571)", "pathway": " (mmu:17748)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10631978;21750661;6277322;6935664;7254320;8495976;914867", "class_list": "", "function": "Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64485", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:0007263 nitric oxide mediated signal transduction;GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P02802-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70255-1", "uniprot_id": "MPZL2_MOUSE", "mass": 24162.0, "length": 215, "protein_name": "Myelin protein zero-like protein 2", "gene_name": "Mpzl2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mpzl2; Eva1; Eva", "gene_names_refseq": "", "protein_names_uniprotkb": "Myelin protein zero-like protein 2; Epithelial V-like antigen 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 111 (Disease Ontology:DOID:0111640)", "pathway": " (mmu:14012)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;29961571;29982980;9585423", "class_list": "", "function": "Mediates homophilic cell-cell adhesion., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70255-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L314-1", "uniprot_id": "MPEG1_MOUSE", "mass": 78390.0, "length": 713, "protein_name": "Macrophage-expressed gene 1 protein", "gene_name": "Mpeg1", "organism": "Mouse", "refseq_name": "macrophage-expressed gene 1 protein precursor", "refseq_ac": "NP_034951", "gene_names_uniprotkb": "Mpeg1", "gene_names_refseq": "MPS1; Mpeg1; Mpg-1; P-2; PFN2; mPFN2", "protein_names_uniprotkb": "Macrophage-expressed gene 1 protein; Macrophage gene 1 protein; Mpg-1; P-2; PFN2; Perforin-2; Protein MPS1; mPFN2", "protein_names_refseq": "macrophage gene 1 protein; macrophage-expressed gene 1 protein precursor; macrophage-expressed gene 1 protein; perforin-2", "tax_id": 10090, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (mmu:17476)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;16075062;21750661;23257510;23753625;26402460;26418746;26495903;26740625;26831467;30084848;30249808;32064340;32152506;34428180;34730110;35471730;36028507;36245269;37347855;37828378;39627609;7888681", "class_list": "", "function": "Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression., [RefSeq, PubMed]; Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation., [RefSeq, PubMed]; Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells., [RefSeq, PubMed]; Pore-forming protein involved in both innate and adaptive immunity (PubMed:26402460, PubMed:30249808, PubMed:32064340, PubMed:36028507, PubMed:36245269, PubMed:37347855). Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation (PubMed:35471730, PubMed:37347855). Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23257510, PubMed:23753625, PubMed:26402460). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (PubMed:26831467). Required for the antibacterial activity of reactive oxygen species and nitric oxide (PubMed:26402460)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide., [UniProtKB, UniProtKB, UniProtKB]; Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation (PubMed:37347855). Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells (PubMed:37347855). Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming (PubMed:37347855)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1L315;Q61889", "ec_number_list": "", "go_molecular_function": "GO:0022829 wide pore channel activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0030670 phagocytic vesicle membrane;GO:0045335 phagocytic vesicle;GO:0061474 phagolysosome membrane;GO:0036019 endolysosome", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0002468 dendritic cell antigen processing and presentation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "A1L314-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A7Y5-1", "uniprot_id": "MIIP_MOUSE", "mass": 42828.0, "length": 387, "protein_name": "Migration and invasion-inhibitory protein", "gene_name": "Miip", "organism": "Mouse", "refseq_name": "migration and invasion-inhibitory protein isoform 2", "refseq_ac": "NP_001020536", "gene_names_uniprotkb": "Miip; D4Wsu114e; Iip45", "gene_names_refseq": "D4Wsu114e; IIP45; Miip", "protein_names_uniprotkb": "Migration and invasion-inhibitory protein; IIp45; Invasion-inhibitory protein 45", "protein_names_refseq": "invasion inhibitory protein 45; migration and invasion-inhibitory protein isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:28010)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZ92;Q8CFZ8;Q8VD71", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0010972 negative regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2A7Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AQ14-1", "uniprot_id": "MS18B_MOUSE", "mass": 26861.0, "length": 241, "protein_name": "Protein Mis18-beta", "gene_name": "Oip5", "organism": "Mouse", "refseq_name": "protein Mis18-beta", "refseq_ac": "NP_001036118", "gene_names_uniprotkb": "Oip5; Ms18b", "gene_names_refseq": "5730547N13Rik; Lint-25; Ms18b; Oip5", "protein_names_uniprotkb": "Protein Mis18-beta; Opa-interacting protein 5 homolog", "protein_names_refseq": "opa-interacting protein 5 homolog; protein Mis18-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:70645); (R-MMU-606279)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22872234;24516558;34261477", "class_list": "", "function": "Increase of Oip5 may associate with development of obesity. Publication Status: Online-Only, [RefSeq, PubMed]; Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AW4;Q14BH1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0015030 Cajal body", "go_biological_process": "GO:0051301 cell division;GO:0034080 CENP-A containing chromatin assembly;GO:0140462 pericentric heterochromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AQ14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTR0-1", "uniprot_id": "MMP16_MOUSE", "mass": 69571.0, "length": 607, "protein_name": "Matrix metalloproteinase-16", "gene_name": "Mmp16", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-16 preproprotein", "refseq_ac": "NP_062698", "gene_names_uniprotkb": "Mmp16", "gene_names_refseq": "MT-MMP 3; MT3-MMP; Mmp16; Mt3mmp", "protein_names_uniprotkb": "Matrix metalloproteinase-16; 3.4.24.-; MMP-16; MT-MMP 3; MT3-MMP; MT3MMP; MTMMP3; Membrane-type matrix metalloproteinase 3; Membrane-type-3 matrix metalloproteinase", "protein_names_refseq": "Membrane type 3-MMP; matrix metalloproteinase-16 preproprotein; matrix metalloproteinase-16; membrane-type matrix metalloproteinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:17389); (R-MMU-1592389); (R-MMU-9839383)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells (By similarity)., [UniProtKB]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit retarded growth of the skeleton, especially in the cranium and long bones. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEQ6;Q9ERT6", "ec_number_list": "3.4.24.-;3.4.21.75;3.4.24.24;3.4.24.80", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0097094 craniofacial suture morphogenesis;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WTR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZJ0-1", "uniprot_id": "MPPD2_MOUSE", "mass": 33374.0, "length": 294, "protein_name": "Metallophosphoesterase MPPED2", "gene_name": "Mpped2", "organism": "Mouse", "refseq_name": "metallophosphoesterase MPPED2 isoform a", "refseq_ac": "NP_001137155", "gene_names_uniprotkb": "Mpped2", "gene_names_refseq": "239Fb; 2700082O15Rik; Mpped2", "protein_names_uniprotkb": "Metallophosphoesterase MPPED2; 3.1.-.-; Metallophosphoesterase domain-containing protein 2", "protein_names_refseq": "metallophosphoesterase MPPED2 isoform a; metallophosphoesterase MPPED2; metallophosphoesterase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77015)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0016208 AMP binding;GO:0008081 phosphoric diester hydrolase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0019002 GMP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CZJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NC32-1", "uniprot_id": "MOT11_MOUSE", "mass": 45235.0, "length": 447, "protein_name": "Monocarboxylate transporter 11", "gene_name": "Slc16a11", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 11", "refseq_ac": "NP_694721", "gene_names_uniprotkb": "Slc16a11; Mct11", "gene_names_refseq": "MCT 11; MNCb-2717; Slc16a11", "protein_names_uniprotkb": "Monocarboxylate transporter 11; MCT 11; Solute carrier family 16 member 11", "protein_names_refseq": "monocarboxylate transporter 11; novel RNA polymerase Rpb1 C-terminal repeat domain containing protein; solute carrier family 16 member 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:216867)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30673611;31185508", "class_list": "", "function": "Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice., [RefSeq, PubMed]; Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes., [RefSeq, PubMed]; Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BDD4;Q5NC33", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0050833 pyruvate transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5NC32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVN4-1", "uniprot_id": "MTEF4_MOUSE", "mass": 40249.0, "length": 346, "protein_name": "Transcription termination factor 4, mitochondrial", "gene_name": "Mterf4", "organism": "Mouse", "refseq_name": "transcription termination factor 4, mitochondrial isoform 1", "refseq_ac": "NP_835152", "gene_names_uniprotkb": "Mterf4; Mterfd2", "gene_names_refseq": "1810059A23Rik; 4933412H03Rik; Mterf4; Mterfd2", "protein_names_uniprotkb": "Transcription termination factor 4, mitochondrial; Mitochondrial transcription termination factor 4; mTERF domain-containing protein 2", "protein_names_refseq": "MTERF domain containing 2; mTERF domain-containing protein 2; transcription termination factor 4, mitochondrial isoform 1; transcription termination factor 4, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:69821)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21531335;21750661;22214595;27894840;30690068", "class_list": "", "function": "Mterfd2 might have multiple roles in organogenesis., [RefSeq, PubMed]; Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S (By similarity). Targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit., [UniProtKB, PubMed]; The levels of MTERF4 protein were significantly increased in the hippocampus of APP/PS1 mice, an animal model of Alzheimer's disease., [RefSeq, PubMed]; The results demonstrate that MTERF4 regulates mitochondrial protein translation and is essential for proper brown adipose tissue thermogenic activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LQ0", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0140517 protein-RNA adaptor activity;GO:0140691 RNA folding chaperone;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0007507 heart development;GO:0006364 rRNA processing;GO:0043010 camera-type eye development;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0061668 mitochondrial ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BVN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCJ6-1", "uniprot_id": "MRGRF_MOUSE", "mass": 38523.0, "length": 343, "protein_name": "Mas-related G protein-coupled receptor member F", "gene_name": "Mrgprf", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member F", "refseq_ac": "NP_663354", "gene_names_uniprotkb": "Mrgprf; Mrgf", "gene_names_refseq": "Mgrc; MrgF; Mrgprf", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member F; Mas-related gene F protein", "protein_names_refseq": "G protein-coupled receptor RTA; Mas-related G protein-coupled receptor c; mas-related G-protein coupled receptor member F; mas-related gene F protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:211577)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11551509;17634244;21750661;21912971", "class_list": "", "function": "ORF49 protein promoted the ability of RTA to activate downstream target promoters and enhanced murine gammaherpesvirus 68 replication, [RefSeq, PubMed]; Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain., [UniProtKB]; The number of enteric neurons expressing MrgE and MrgF receptors was significantly reduced during intestinal schistosomiasis and ileitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9884, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZB6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VCJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGG6-1", "uniprot_id": "MSPD3_MOUSE", "mass": 25433.0, "length": 235, "protein_name": "Motile sperm domain-containing protein 3", "gene_name": "Mospd3", "organism": "Mouse", "refseq_name": "motile sperm domain-containing protein 3", "refseq_ac": "NP_001241691", "gene_names_uniprotkb": "Mospd3", "gene_names_refseq": "1190005J19Rik; 5133401H10Rik; Gtig2; Mospd3; R124", "protein_names_uniprotkb": "Motile sperm domain-containing protein 3", "protein_names_refseq": "gene trap integration gene 2; motile sperm domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:68929)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15533722;21750661;22872234;31219806;38057958", "class_list": "", "function": "Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z750-1", "uniprot_id": "MRO2A_MOUSE", "mass": 190012.0, "length": 1679, "protein_name": "Maestro heat-like repeat-containing protein family member 2A", "gene_name": "Mroh2a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mroh2a; Heatr7b1", "gene_names_refseq": "", "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 2A; HEAT repeat-containing protein 7B1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040766)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30059200", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEL2-1", "uniprot_id": "MTMRE_MOUSE", "mass": 72443.0, "length": 648, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14", "gene_name": "Mtmr14", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 isoform 1", "refseq_ac": "NP_081125", "gene_names_uniprotkb": "Mtmr14", "gene_names_refseq": "1110061O04Rik; Mtmr14", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14; 3.1.3.95; Myotubularin-related protein 14; Phosphatidylinositol-3-phosphate phosphatase; mJumpy", "protein_names_refseq": "mJumpy; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "centronuclear myopathy 1 (Disease Ontology:DOID:0111223)", "pathway": " (mmu:97287); (R-MMU-1632852); (R-MMU-1660499)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17008356;19465920;20817957;21183079;21750661;32768948;32819563;34428180;36314496;38401642", "class_list": "", "function": "A knockout mice were more susceptible to exercise-induced muscle damage, a trademark of muscle functional changes in older subjects, [RefSeq, PubMed]; Data report that mice deficient in the newly identified phosphatidylinositol phosphate phosphatase MIP/MTMR14 (muscle-specific inositol phosphatase) show muscle weakness and fatigue., [RefSeq, PubMed]; Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate., [UniProtKB, UniProtKB]; MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy., [RefSeq, PubMed]; MTMR14 protects against hepatic ischemia-reperfusion injury through interacting with AKT signaling in vivo and in vitro., [RefSeq, PubMed]; Myotubularin-Related Protein14 Prevents Neointima Formation and Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like Kinase1., [RefSeq, PubMed]; Overexpression of MTMR14 induced learning and memory impairments in 2-month-old C57 mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.67;3.1.3.86;3.1.3.95;3.1.3.36;3.1.3.-;3.1.3.64", "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0001726 ruffle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VEL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1F5-1", "uniprot_id": "MRNIP_MOUSE", "mass": 36897.0, "length": 335, "protein_name": "MRN complex-interacting protein", "gene_name": "Mrnip", "organism": "Mouse", "refseq_name": "MRN complex-interacting protein", "refseq_ac": "NP_080819", "gene_names_uniprotkb": "Mrnip; 3010026O09Rik", "gene_names_refseq": "2900016G09Rik; 3010026O09Rik; Mrnip", "protein_names_uniprotkb": "MRN complex-interacting protein; MRN-interacting protein", "protein_names_refseq": "MRN complex-interacting protein; MRN-interacting protein; UPF0544 protein C5orf45 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68067)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CX85", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030870 Mre11 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0045860 positive regulation of protein kinase activity;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D1F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61184-1", "uniprot_id": "MTR1A_MOUSE", "mass": 39837.0, "length": 353, "protein_name": "Melatonin receptor type 1A", "gene_name": "Mtnr1a", "organism": "Mouse", "refseq_name": "melatonin receptor type 1A", "refseq_ac": "NP_032665", "gene_names_uniprotkb": "Mtnr1a", "gene_names_refseq": "MR; MelR; Mtnr1a", "protein_names_uniprotkb": "Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor", "protein_names_refseq": "Mel1a receptor; mel-1A-R; melatonin receptor type 1A", "tax_id": 10090, "disease": "idiopathic juvenile osteoporosis (Disease Ontology:DOID:12559); Huntington's disease (Disease Ontology:DOID:12858); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:17773); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;25428506;32818016;32958651;39413162;8754776", "class_list": "", "function": "Changes in melatonin receptor expression in a murine model of glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (By similarity). Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (PubMed:32958651)., [UniProtKB, PubMed]; Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042562 hormone binding;GO:0008502 melatonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043235 receptor complex", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0046676 negative regulation of insulin secretion;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CTY5-1", "uniprot_id": "MICU3_MOUSE", "mass": 59810.0, "length": 523, "protein_name": "Calcium uptake protein 3, mitochondrial", "gene_name": "Micu3", "organism": "Mouse", "refseq_name": "calcium uptake protein 3, mitochondrial", "refseq_ac": "NP_084386", "gene_names_uniprotkb": "Micu3; Efha2", "gene_names_refseq": "2900075B16Rik; Efha2; Micu3", "protein_names_uniprotkb": "Calcium uptake protein 3, mitochondrial; EF-hand domain-containing family member A2", "protein_names_refseq": "EF-hand domain family, member A2; EF-hand domain-containing family member A2; calcium uptake protein 3, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:78506); (R-MMU-8949215); (R-MMU-8949664)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18614015;21750661;23409044;29725115;31219806;33300544;34845191;36878048;38018177;38747181", "class_list": "", "function": "MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy., [RefSeq, PubMed]; MICU3 forms a disulfide bond-mediated dimer with MICU1, but not with MICU2, and it acts as enhancer of MCU-dependent mitochondrial Ca(2+) uptake. Silencing of MICU3 in primary cortical neurons impairs Ca(2+) signals elicited by synaptic activity, thus suggesting a specific role in regulating neuronal function. GeneRIF: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake, [RefSeq, PubMed]; Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction., [RefSeq, PubMed]; Tissue-specific calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which specifically regulates MCU channel activity in the central nervous system and skeletal muscle (PubMed:38018177). Senses calcium level via its EF-hand domains: compared to MICU1 and MICU2, MICU3 has a higher affinity for calcium (By similarity). MICU1 and MICU3 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (By similarity). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 and MICU3 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU3 heterodimer away from the pore, allowing calcium permeation through the MCU channel (By similarity). The high calcium affinity of MICU3 lowers the calcium threshold necessary for calcium permeation through the MCU channel (By similarity). The MICU1-MICU3 heterodimer promotes flexibility of neurotransmission in neuronal cells by enhancing mitochondrial calcium uptake in presynapses (By similarity). It is also required to increase mitochondrial calcium uptake in skeletal muscle cells, thereby increasing ATP production (PubMed:34845191, PubMed:38018177)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:1990246 uniplex complex;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0001956 positive regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CTY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Z3-1", "uniprot_id": "MTO1_MOUSE", "mass": 74332.0, "length": 669, "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial", "gene_name": "Mto1", "organism": "Mouse", "refseq_name": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial precursor", "refseq_ac": "NP_080934", "gene_names_uniprotkb": "Mto1", "gene_names_refseq": "2310039H01Rik; 5730419A02Rik; Mto1", "protein_names_uniprotkb": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial; Mitochondrial tRNA translation optimization 1; Protein MTO1 homolog, mitochondrial", "protein_names_refseq": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial precursor; 5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial; mitochondrial translation optimization 1 homolog; protein MTO1 homolog, mitochondrial", "tax_id": 10090, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286); combined oxidative phosphorylation deficiency 10 (Disease Ontology:DOID:0111480)", "pathway": " (mmu:68291)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14522080;21750661;25506927;25552653;30059200;35820727", "class_list": "", "function": "Component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Here described is an MTO1-deficient mouse model generated by gene trap mutagenesis that mirrors the human phenotype showing complex I defect and cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; MTO1 mediates tRNA modification and controls mitochondrial translation rate in a highly tissue-specific manner associated with tissue-specific oxidative phosphorylation defects., [RefSeq, PubMed]; These observations suggest that the mouse MTO1 is a structural and functional homolog of yeast MTO1, thereby playing a role in the mitochondrial tRNA modification and protein synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2Q5", "ec_number_list": "", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0160236 tRNA 5-taurinomethyluridine synthase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:7770010 GTPBP3-MTO1 complex", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0070899 mitochondrial tRNA wobble uridine modification;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q923Z3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXT8-1", "uniprot_id": "MPPB_MOUSE", "mass": 54614.0, "length": 489, "protein_name": "Mitochondrial-processing peptidase subunit beta", "gene_name": "Pmpcb", "organism": "Mouse", "refseq_name": "mitochondrial-processing peptidase subunit beta isoform 1 precursor", "refseq_ac": "NP_082707", "gene_names_uniprotkb": "Pmpcb", "gene_names_refseq": "3110004O18Rik; MPP11; MPPB; MPPP52; Pmpcb", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit beta; 3.4.24.64; Beta-MPP; P-52", "protein_names_refseq": "P-52; beta-MPP; mitochondrial-processing peptidase subunit beta isoform 1 precursor; mitochondrial-processing peptidase subunit beta", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); multiple mitochondrial dysfunctions syndrome 6 (Disease Ontology:DOID:0070332)", "pathway": " (mmu:73078); (R-MMU-8949664)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19656850;21750661;22645316;24788674;24903103;28135057;28528544;37507081", "class_list": "", "function": "Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data show that Afg3l1 or Afg3l2 are required for maturation of newly imported paraplegin subunits after their cleavage by MPP., [RefSeq, PubMed]; OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.-;3.6.-.-;3.4.24.64", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0009003 signal peptidase activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0016485 protein processing;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CXT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MB2-1", "uniprot_id": "MTFR1_MOUSE", "mass": 35905.0, "length": 328, "protein_name": "Mitochondrial fission regulator 1", "gene_name": "Mtfr1", "organism": "Mouse", "refseq_name": "mitochondrial fission regulator 1", "refseq_ac": "NP_001240319", "gene_names_uniprotkb": "Mtfr1; Chppr; Kiaa0009", "gene_names_refseq": "1300002C08Rik; 1700080D04Rik; 2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2; Mtfr1", "protein_names_uniprotkb": "Mitochondrial fission regulator 1; Chondrocyte protein with a poly-proline region", "protein_names_refseq": "chondrocyte protein with a poly-proline region; mitochondrial fission regulator 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67472)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15389597;17242355;17709566;20568109;21183079;21750661;26633713", "class_list": "", "function": "CHPPR is able to promote mitochondrial fission with a sequence specific mechanism suggesting that this event may be relevant to late stage of chondrocyte differentiation [CHPPR], [RefSeq, PubMed]; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study defines the NFAT4/ miR-324-5p/Mtfr1 axis, which participates in the regulation of mitochondrial fission and cardiomyocyte apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration and may affect male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQZ4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99MB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WW4-1", "uniprot_id": "MRGA2_MOUSE", "mass": 34427.0, "length": 305, "protein_name": "Mas-related G protein-coupled receptor member A2B", "gene_name": "Mrgpra2b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mrgpra2b; Mrga2; Mrgpra2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A2B; Mas-related G protein-coupled receptor member A2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:235712); (mmu:668727)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11551509;21750661", "class_list": "", "function": "Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3D5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038182 G protein-coupled bile acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQV6-1", "uniprot_id": "MLP3B_MOUSE", "mass": 14617.0, "length": 125, "protein_name": "Microtubule-associated protein 1 light chain 3 beta", "gene_name": "Map1lc3b", "organism": "Mouse", "refseq_name": "microtubule-associated protein 1 light chain 3 beta isoform 1", "refseq_ac": "NP_080436", "gene_names_uniprotkb": "Map1lc3b; Map1alc3; Map1lc3", "gene_names_refseq": "1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B; Map1lc3b; Map1lc3", "protein_names_uniprotkb": "Microtubule-associated protein 1 light chain 3 beta; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; Microtubule-associated proteins 1A/1B light chain 3B", "protein_names_refseq": "MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; microtubule-associated protein 1 light chain 3 beta isoform 1; microtubule-associated proteins 1A/1B light chain 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:67443); (R-MMU-1632852); (R-MMU-5205685); (R-MMU-8854214); (R-MMU-8934903); (R-MMU-9664873); (R-MMU-9755511)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "11266458;12088839;12207896;14530254;15325588;16452087;21383079;21750661;23399561;24089209;29937374;30936319;33300544;33795848;34338405", "class_list": "", "function": "MAP1B is involved in the initial stages of axonogenesis, as shown by reduced axon length and increased growth cone size of cultured dorsal root ganglion neurons from MAP1B deficient mice., [RefSeq, PubMed]; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9W5;Q9D1R0", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0006914 autophagy;GO:0009267 cellular response to starvation;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9CQV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35308-1", "uniprot_id": "MOT3_MOUSE", "mass": 51556.0, "length": 492, "protein_name": "Monocarboxylate transporter 3", "gene_name": "Slc16a8", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 3", "refseq_ac": "NP_065262", "gene_names_uniprotkb": "Slc16a8; Mct3", "gene_names_refseq": "Mct3; Slc16a8", "protein_names_uniprotkb": "Monocarboxylate transporter 3; MCT 3; Proton-coupled monocarboxylate transporter 3; Solute carrier family 16 member 8", "protein_names_refseq": "MCT 3; monocarboxylate transporter 3; preferentially expressed in RPE cells and choroid plexus epithelium; proton-coupled monocarboxylate transporter 3; solute carrier family 16 member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:57274); (R-MMU-210991); (R-MMU-433692)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11287345;12601063;17318265;18524945", "class_list": "", "function": "Disruption of Mct3 leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current., [RefSeq, PubMed]; MCT8-null mice developed without overt deficits but also exhibited distorted 3,5,3'-triiodothyronine (T3) and thyroxine (T4) serum levels, resulting in increased hepatic activity of type 1 deiodinase (D1)., [RefSeq, PubMed]; Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play an essential role in maintenance of metabolic and ionic homeostasis of the outer retina (PubMed:18524945)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35308-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55123-1", "uniprot_id": "MMP10_MOUSE", "mass": 53911.0, "length": 476, "protein_name": "Stromelysin-2", "gene_name": "Mmp10", "organism": "Mouse", "refseq_name": "stromelysin-2 preproprotein", "refseq_ac": "NP_062344", "gene_names_uniprotkb": "Mmp10", "gene_names_refseq": "MMP-10; Mmp10; SL-2", "protein_names_uniprotkb": "Stromelysin-2; 3.4.24.22; MMP-10; Matrix metalloproteinase-10; SL-2; Transin-2", "protein_names_refseq": "matrix metalloproteinase 10; stromelysin-2 preproprotein; stromelysin-2; transin-2", "tax_id": 10090, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588); end stage renal disease (Disease Ontology:DOID:783); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:17384); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "16075062;36650344;37652204;37844469;9427548", "class_list": "", "function": "Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase., [UniProtKB]; MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization., [RefSeq, PubMed]; Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFkappaBeta pathway inhibition., [RefSeq, PubMed]; Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.22;3.4.24.34;3.4.21.4;3.4.24.17;3.4.24.24;3.4.24.-;3.4.24.65;3.4.24.35;3.4.24.23;3.4.21.37;3.4.21.1;3.4.24.7", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030334 regulation of cell migration;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O55123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70138-1", "uniprot_id": "MMP8_MOUSE", "mass": 53126.0, "length": 465, "protein_name": "Neutrophil collagenase", "gene_name": "Mmp8", "organism": "Mouse", "refseq_name": "neutrophil collagenase preproprotein", "refseq_ac": "NP_032637", "gene_names_uniprotkb": "Mmp8", "gene_names_refseq": "Mmp8", "protein_names_uniprotkb": "Neutrophil collagenase; 3.4.24.34; Collagenase 2; MMP-8; Matrix metalloproteinase-8", "protein_names_refseq": "collagenase-2; matrix metalloproteinase-8; neutrophil collagenase preproprotein; neutrophil collagenase", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:17394); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;18250455;26740625;27802388;29187734;38326622;38419037;9516153;9727011", "class_list": "", "function": "Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution., [UniProtKB]; Circulating myeloid-derived MMP8 in stress susceptibility and depression., [RefSeq, PubMed]; Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88733;Q6GTR5", "ec_number_list": "3.2.1.18;3.4.24.22;3.4.24.34;3.4.22.27;1.1.1.42;4.1.2.13;3.4.21.4;3.4.21.-;3.2.1.17;1.16.3.1;3.4.23.5;3.3.2.6;3.4.11.4;3.4.24.17;3.1.3.48;3.4.24.24;3.4.24.-;3.4.24.65;3.4.24.35;3.5.4.5;3.4.24.23;3.6.5.2;3.4.21.37;3.5.3.1;3.2.1.166;1.8.3.2;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.7.10.2;2.3.2.5;5.4.2.2;3.1.21.-;3.2.1.14;3.4.24.7;3.5.1.3;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:1903980 positive regulation of microglial cell activation;GO:0071222 cellular response to lipopolysaccharide;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70138-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70324-1", "uniprot_id": "MOT8_MOUSE", "mass": 60025.0, "length": 545, "protein_name": "Monocarboxylate transporter 8", "gene_name": "Slc16a2", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 8", "refseq_ac": "NP_033223", "gene_names_uniprotkb": "Slc16a2; Mct8; Xpct", "gene_names_refseq": "Mct8; Slc16a2; Xpct", "protein_names_uniprotkb": "Monocarboxylate transporter 8; MCT 8; Solute carrier family 16 member 2; X-linked PEST-containing transporter", "protein_names_refseq": "MCT 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); X-linked PEST-containing transporter; monocarboxylate transporter 8; solute carrier family 16 member 2", "tax_id": 10090, "disease": "Allan-Herndon-Dudley syndrome (Disease Ontology:DOID:0050631); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:20502); (R-MMU-879518)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12045143;12773420;18687783;19147674;19641107;21183079;25428506;30084848;31436139;32143555;34428180;38396788;38901782;39018199;9545634", "class_list": "", "function": "Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice., [RefSeq, PubMed]; Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium., [RefSeq, PubMed]; Energy metabolism in the context of Sertoli cell-germ cell metabolic cooperation where lactate is produced in somatic cells and transported to germ cells occurs via monocarboxylate transporters., [RefSeq, PubMed]; Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient (PubMed:31436139). Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (PubMed:19147674). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3S9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015171 amino acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006590 thyroid hormone generation;GO:0042403 thyroid hormone metabolic process;GO:0070460 thyroid-stimulating hormone secretion;GO:2000178 negative regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88441-1", "uniprot_id": "MTX2_MOUSE", "mass": 29758.0, "length": 263, "protein_name": "Metaxin-2", "gene_name": "Mtx2", "organism": "Mouse", "refseq_name": "metaxin-2", "refseq_ac": "NP_058084", "gene_names_uniprotkb": "Mtx2; MNCb-0780", "gene_names_refseq": "1500012G02Rik; Mtx2", "protein_names_uniprotkb": "Metaxin-2; Mitochondrial outer membrane import complex protein 2", "protein_names_refseq": "metaxin-2; mitochondrial outer membrane import complex protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53375)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10381257;33300544;34428180;37507081;38250156", "class_list": "", "function": "Involved in transport of proteins into the mitochondrion., [UniProtKB, PubMed]; Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFR2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0006839 mitochondrial transport;GO:0015031 protein transport;GO:0070096 mitochondrial outer membrane translocase complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88441-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88910-1", "uniprot_id": "MPP3_MOUSE", "mass": 64401.0, "length": 568, "protein_name": "MAGUK p55 subfamily member 3", "gene_name": "Mpp3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mpp3; Dlgh3", "gene_names_refseq": "", "protein_names_uniprotkb": "MAGUK p55 subfamily member 3; Discs large homolog 3; Protein MPP3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "14988405;15466885;16519681;16914526;21750661;23658188;23893895;33300544;34428180;9838122", "class_list": "", "function": "Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (By similarity). Stabilizes HTR2C at the plasma membrane and prevents its desensitization (PubMed:16914526). May participates in the maintenance of adherens junctions (PubMed:23658188, PubMed:23893895)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q5S2", "ec_number_list": "", "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88910-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00536-1", "uniprot_id": "MOS_MOUSE", "mass": 37886.0, "length": 343, "protein_name": "Proto-oncogene serine/threonine-protein kinase mos", "gene_name": "Mos", "organism": "Mouse", "refseq_name": "proto-oncogene serine/threonine-protein kinase mos", "refseq_ac": "NP_064405", "gene_names_uniprotkb": "Mos", "gene_names_refseq": "Mos; c-mos", "protein_names_uniprotkb": "Proto-oncogene serine/threonine-protein kinase mos; 2.7.11.1; Oocyte maturation factor mos; Proto-oncogene c-Mos", "protein_names_refseq": "Moloney sarcoma oncogene; c-mos proto-oncogene; oocyte maturation factor mos; proto-oncogene c-Mos; proto-oncogene serine/threonine-protein kinase mos", "tax_id": 10090, "disease": "", "pathway": " (mmu:17451)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "31219806;34293340;6173134;6256659;6292737;6300424", "class_list": "", "function": "Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation., [UniProtKB, UniProtKB]; Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PV67;F6UHW1;Q61886;Q61887;Q78EH5", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0043426 MRF binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0000165 MAPK cascade;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P00536-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02815-1", "uniprot_id": "MUCL2_MOUSE", "mass": 14802.0, "length": 138, "protein_name": "Mucin-like protein 2", "gene_name": "Mucl2", "organism": "Mouse", "refseq_name": "mucin-like protein 2 precursor", "refseq_ac": "NP_033293", "gene_names_uniprotkb": "Mucl2; Spt-1; Spt1", "gene_names_refseq": "Mucl2; Spt-1; Spt1", "protein_names_uniprotkb": "Mucin-like protein 2; 16.5 kDa submandibular gland glycoprotein; Salivary protein 1", "protein_names_refseq": "16.5 kDa submandibular gland glycoprotein; mucin-like protein 2 precursor; mucin-like protein 2; salivary protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20770)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17599412;21750661;2482730;2921944;6546617", "class_list": "", "function": "The data underline a direct role for Aire in tissue-restricted antigens expression and suggest that modulation of Aire has a potential to control central tolerance and autoimmunity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQK8;Q62263;Q9DA65", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02815-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11589-1", "uniprot_id": "MUP2_MOUSE", "mass": 20664.0, "length": 180, "protein_name": "Major urinary protein 2", "gene_name": "Mup2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mup2", "gene_names_refseq": "", "protein_names_uniprotkb": "Major urinary protein 2; MUP 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:17841)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10583419;10605093;21750661;3600652;37453647", "class_list": "", "function": "Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JF6", "ec_number_list": "", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005576 extracellular region", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P11589-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12025-1", "uniprot_id": "MK_MOUSE", "mass": 15434.0, "length": 140, "protein_name": "Midkine", "gene_name": "Mdk", "organism": "Mouse", "refseq_name": "midkine isoform a precursor", "refseq_ac": "NP_001012335", "gene_names_uniprotkb": "Mdk; Mk", "gene_names_refseq": "MK; Mdk; Mek", "protein_names_uniprotkb": "Midkine; MK; Retanoic acid-responsive protein; Retinoic acid-induced differentiation factor", "protein_names_refseq": "midkine isoform a precursor; retanoic acid-responsive protein; retinoic acid-induced differentiation factor; retinoic acid-responsive protein", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316); endometriosis (Disease Ontology:DOID:289); brain infarction (Disease Ontology:DOID:3454); coronary stenosis (Disease Ontology:DOID:4248); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:17242); (R-MMU-201556); (R-MMU-9851151)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10096022;10212223;10683378;10978312;12084985;15482347;15509530;16619002;16901907;17015789;17121547;17230638;19060126;20200993;21185956;22323540;2345177;2355021;24458438;25551381;28183532;29233575;3355557;8827451;9089390", "class_list": "glycogene", "function": "Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16901907). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:17230638). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:10683378, PubMed:15482347, PubMed:15509530, PubMed:17015789, PubMed:17230638, PubMed:19060126, PubMed:24458438, PubMed:25551381, PubMed:28183532, PubMed:29233575). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:15509530, PubMed:24458438, PubMed:28183532). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378, PubMed:15509530). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:28183532). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (PubMed:17015789, PubMed:19060126). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (PubMed:15482347, PubMed:25551381). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (PubMed:17230638). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (By similarity). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (By similarity). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:10978312). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (PubMed:16901907). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (By similarity). Binds LRP1; promotes neuronal survival (By similarity). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (By similarity). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (By similarity). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (By similarity). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (PubMed:29233575). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (PubMed:20200993, PubMed:21185956). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (PubMed:10096022, PubMed:16619002, PubMed:17121547)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:1904399 heparan sulfate binding;GO:0008083 growth factor activity;GO:0035374 chondroitin sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0042995 cell projection", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0021681 cerebellar granular layer development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P12025-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19467-1", "uniprot_id": "MUC13_MOUSE", "mass": 58701.0, "length": 573, "protein_name": "Mucin-13", "gene_name": "Muc13", "organism": "Mouse", "refseq_name": "mucin-13 precursor", "refseq_ac": "NP_034869", "gene_names_uniprotkb": "Muc13; Ly64", "gene_names_refseq": "114/A10; 14/A10; Lrrp; Ly64; Muc13; NJ-1", "protein_names_uniprotkb": "Mucin-13; Cell surface antigen 114/A10; Lymphocyte antigen 64; MUC-13", "protein_names_refseq": "MUC-13; cell surface antigen 114/A10; lymphocyte antigen 64; mucin-13 precursor; mucin-13", "tax_id": 10090, "disease": "ischemia (Disease Ontology:DOID:326)", "pathway": " (mmu:17063); (R-MMU-913709); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273); (R-MMU-977068)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "11922618;21636645;2784793;37174625;37660948;38579936", "class_list": "", "function": "Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling., [UniProtKB]; Hypothesize that NJ-1(+)megakaryocytes (MKs) are immature MKs and the NJ-1 molecule is involved in MK adhesion to endothelial cells [NJ-1], [RefSeq, PubMed]; IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier., [RefSeq, PubMed]; Protective role in the colonic epithelium by inhibiting toxin-induced apoptosis, [RefSeq, PubMed]; Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030277 maintenance of gastrointestinal epithelium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P19467-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28665-1", "uniprot_id": "MUG1_MOUSE", "mass": 165298.0, "length": 1476, "protein_name": "Murinoglobulin-1", "gene_name": "Mug1", "organism": "Mouse", "refseq_name": "murinoglobulin-1 precursor", "refseq_ac": "NP_032671", "gene_names_uniprotkb": "Mug1; Mug-1", "gene_names_refseq": "Mug1", "protein_names_uniprotkb": "Murinoglobulin-1; MuG1", "protein_names_refseq": "murinoglobulin-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17836)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17330941;1840592;20571061;26495903;26740625;27031383;28011936;30084848;33725478;34428180;35230372;35984892;37453647;37507081;39627609;39927985", "class_list": "", "function": "A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective., [UniProtKB]; Macrophages secrete murinoglobulin-1 and galectin-3 to regulate neutrophil degranulation after myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNE7;Q80XE6", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007566 embryo implantation", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P28665-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30306-1", "uniprot_id": "MPIP2_MOUSE", "mass": 65490.0, "length": 576, "protein_name": "M-phase inducer phosphatase 2", "gene_name": "Cdc25b", "organism": "Mouse", "refseq_name": "M-phase inducer phosphatase 2 isoform a", "refseq_ac": "NP_075606", "gene_names_uniprotkb": "Cdc25b; Cdc25m2", "gene_names_refseq": "Cdc25b", "protein_names_uniprotkb": "M-phase inducer phosphatase 2; 3.1.3.48; Dual specificity phosphatase Cdc25B", "protein_names_refseq": "M-phase inducer phosphatase 2 isoform a; M-phase inducer phosphatase 2; dual specificity phosphatase Cdc25B", "tax_id": 10090, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:12531); (R-MMU-69273); (R-MMU-69656)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "1313771;19035343;20083600;21212267;22348958;23326474;25059436;25349079;31602201;34428180;36596698", "class_list": "", "function": "Control of G2 Phase Duration by CDC25B Modulates the Switch from Direct to Indirect Neurogenesis in the Neocortex., [RefSeq, PubMed]; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. The three isoforms seem to have a different level of activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LP3", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.11.22;2.7.11.23;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0007144 female meiosis I;GO:0006468 protein phosphorylation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P30306-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33435-1", "uniprot_id": "MMP13_MOUSE", "mass": 54182.0, "length": 472, "protein_name": "Collagenase 3", "gene_name": "Mmp13", "organism": "Mouse", "refseq_name": "collagenase 3 preproprotein", "refseq_ac": "NP_032633", "gene_names_uniprotkb": "Mmp13", "gene_names_refseq": "Clg; MMP-13; Mmp13; Mmp1", "protein_names_uniprotkb": "Collagenase 3; 3.4.24.-; MMP-13; Matrix metalloproteinase-13", "protein_names_refseq": "collagenase 3 preproprotein; collagenase 3; collagenase-1; interstitial collagenase; matrix metalloproteinase 13", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia, Missouri type (Disease Ontology:DOID:0080030); meningococcal meningitis (Disease Ontology:DOID:0080176); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); vulva cancer (Disease Ontology:DOID:1245); anodontia (Disease Ontology:DOID:13714); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:17386); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-2022090)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10525409;1383028;15539485;15563592;17987127;19590036;22880047", "class_list": "", "function": "Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.22;3.4.24.34;3.4.22.27;3.4.22.15;3.4.21.4;3.4.22.1;3.4.24.17;3.4.24.24;3.4.24.-;3.4.24.65;3.4.24.35;3.4.24.80;3.4.22.38;3.4.24.23;3.4.24.7", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0048306 calcium-dependent protein binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0046581 intercellular canaliculus", "go_biological_process": "GO:0006508 proteolysis;GO:0007507 heart development;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P33435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47945-1", "uniprot_id": "MT4_MOUSE", "mass": 6277.0, "length": 62, "protein_name": "Metallothionein-4", "gene_name": "Mt4", "organism": "Mouse", "refseq_name": "metallothionein-4", "refseq_ac": "NP_032657", "gene_names_uniprotkb": "Mt4", "gene_names_refseq": "MT-IV; Mt4", "protein_names_uniprotkb": "Metallothionein-4; MT-4; MT-IV; Metallothionein-IV", "protein_names_refseq": "MT-4; metallothionein-4; metallothionein-IV", "tax_id": 10090, "disease": "", "pathway": " (mmu:17752)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15033980;16556599;8003488", "class_list": "", "function": "Analysis of metal-thiolate clusters in epithelium-specific metallothionein-4, [RefSeq, PubMed]; MT4 plays a physiological role related with copper requirements in epithelial differentiating tissues, where MT4 is expressed, [RefSeq, PubMed]; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046686 response to cadmium ion;GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47945-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48964-1", "uniprot_id": "MPIP1_MOUSE", "mass": 57806.0, "length": 514, "protein_name": "M-phase inducer phosphatase 1", "gene_name": "Cdc25a", "organism": "Mouse", "refseq_name": "M-phase inducer phosphatase 1 isoform 1", "refseq_ac": "NP_031684", "gene_names_uniprotkb": "Cdc25a; Cdc25m3", "gene_names_refseq": "Cdc25a; D9Ertd393e", "protein_names_uniprotkb": "M-phase inducer phosphatase 1; 3.1.3.48; Dual specificity phosphatase Cdc25A", "protein_names_refseq": "M-phase inducer phosphatase 1 isoform 1; M-phase inducer phosphatase 1; dual specificity phosphatase Cdc25A", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:12530); (R-MMU-176187); (R-MMU-5689880); (R-MMU-69200); (R-MMU-69202); (R-MMU-69273); (R-MMU-69601); (R-MMU-69656)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "18936171;21750661;21952136;25605945;30084848;30779550;30985893;31219806;34428180;37914905;40885482;7635051", "class_list": "", "function": "CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25Adagger., [RefSeq, PubMed]; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin-E, in vitro., [UniProtKB, UniProtKB]; Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PVD0", "ec_number_list": "3.1.3.48;3.1.3.2;3.4.19.12;3.1.3.67;3.1.3.-;3.1.3.16;2.7.11.1;3.4.25.1;2.7.11.22;2.7.11.23;2.7.11.24;3.4.26.1;2.3.2.27;2.3.2.32;2.7.11.21;3.1.3.27;3.6.4.13;3.1.3.5;3.1.3.21;3.1.3.18;2.7.11.26", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007077 mitotic nuclear membrane disassembly;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P48964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48967-1", "uniprot_id": "MPIP3_MOUSE", "mass": 50046.0, "length": 447, "protein_name": "M-phase inducer phosphatase 3", "gene_name": "Cdc25c", "organism": "Mouse", "refseq_name": "M-phase inducer phosphatase 3", "refseq_ac": "NP_033990", "gene_names_uniprotkb": "Cdc25c; Cdc25m1", "gene_names_refseq": "Cdc25c; Cdc25", "protein_names_uniprotkb": "M-phase inducer phosphatase 3; 3.1.3.48; Dual specificity phosphatase Cdc25C", "protein_names_refseq": "M-phase inducer phosphatase 3; cell cycle phosphatase CDC25C; cell division cycle control protein 25C; dual specificity phosphatase Cdc25C", "tax_id": 10090, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:12532); (R-MMU-156711); (R-MMU-176187); (R-MMU-5625740); (R-MMU-6804115); (R-MMU-69273); (R-MMU-75035)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "21750661;7601309;8276463", "class_list": "", "function": "Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity., [UniProtKB, UniProtKB]; This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KG6", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.11.1;2.7.11.22;2.7.11.23;2.7.11.13;2.7.11.21;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0050699 WW domain binding;GO:0004725 protein tyrosine phosphatase activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0110032 positive regulation of G2/MI transition of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48967-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59759-1", "uniprot_id": "MRTFB_MOUSE", "mass": 117547.0, "length": 1080, "protein_name": "Myocardin-related transcription factor B", "gene_name": "Mrtfb", "organism": "Mouse", "refseq_name": "myocardin-related transcription factor B isoform 1", "refseq_ac": "NP_705816", "gene_names_uniprotkb": "Mrtfb; Mkl2", "gene_names_refseq": "Gt4-1; MRTF-B; Mkl2; Mrtfb; SOLOIST; mKIAA1243", "protein_names_uniprotkb": "Myocardin-related transcription factor B; MKL/myocardin-like protein 2; MRTF-B", "protein_names_refseq": "MKL/myocardin-like 2; MKL/myocardin-like protein 2; gene trap insertion site 4-1; megakaryoblastic leukemia 2; myocardial related transcription factor B; myocardin-related transcription factor B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239719)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;12397177;16452088;21183079;21750661;22517741;22645316;22826440;25428506;30016717;30059200;30084848;32782141;32848054;34428180;34678516;35822049;36084651;36852467;38582447;38713765;40021952;40885482;40997131", "class_list": "", "function": "Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation., [UniProtKB, PubMed]; Interacts with serum response factor and stimulates its transcriptional activity, [RefSeq, PubMed]; KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB., [RefSeq, PubMed]; The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0098794 postsynapse", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P59759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03358-1", "uniprot_id": "MSX2_MOUSE", "mass": 28915.0, "length": 267, "protein_name": "Homeobox protein MSX-2", "gene_name": "Msx2", "organism": "Mouse", "refseq_name": "homeobox protein MSX-2", "refseq_ac": "NP_038629", "gene_names_uniprotkb": "Msx2; Hox-8.1; Msx-2", "gene_names_refseq": "Hox-8; Hox8.1; Hox8; Msx2", "protein_names_uniprotkb": "Homeobox protein MSX-2; Homeobox protein Hox-8-1", "protein_names_refseq": "homeo box, msh-like 2; homeobox protein Hox-8-1; homeobox protein MSX-2; homeobox, msh-like 2", "tax_id": 10090, "disease": "parietal foramina (Disease Ontology:DOID:0060285); craniosynostosis 2 (Disease Ontology:DOID:0061009); hypertension (Disease Ontology:DOID:10763); craniosynostosis (Disease Ontology:DOID:2340)", "pathway": " (mmu:17702)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10451362;15383550;1673109;1677742;1682128;22633971;8098007", "class_list": "", "function": "Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63856", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060364 frontal suture morphogenesis;GO:0045617 negative regulation of keratinocyte differentiation;GO:0097152 mesenchymal cell apoptotic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q03358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2YDW2-1", "uniprot_id": "MSTO1_MOUSE", "mass": 61230.0, "length": 556, "protein_name": "Protein misato homolog 1", "gene_name": "Msto1", "organism": "Mouse", "refseq_name": "protein misato homolog 1", "refseq_ac": "NP_659147", "gene_names_uniprotkb": "Msto1", "gene_names_refseq": "Msto1; mst", "protein_names_uniprotkb": "Protein misato homolog 1", "protein_names_refseq": "misato homolog 1; protein misato homolog 1", "tax_id": 10090, "disease": "myotonia congenita (Disease Ontology:DOID:2106)", "pathway": " (mmu:229524)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ50;Q3TLZ1;Q3TQV9;Q922H6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0007005 mitochondrion organization;GO:0048311 mitochondrion distribution", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2YDW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UG50-1", "uniprot_id": "MRGX2_MOUSE", "mass": 40304.0, "length": 352, "protein_name": "Mas-related G protein-coupled receptor member X2", "gene_name": "Mrgprx2", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member X2", "refseq_ac": "NP_001030040", "gene_names_uniprotkb": "Mrgprx2; Mrgprb10", "gene_names_refseq": "G370024M05Rik; MrgB10; Mrgprb10; Mrgprx2", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member X2; Mas-related G protein-coupled receptor member B10", "protein_names_refseq": "MAS-related GPR, member B10; mas-related G-protein coupled receptor member B10; mas-related G-protein coupled receptor member X2", "tax_id": 10090, "disease": "", "pathway": " (mmu:243978)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24583173;28987593;33673037;34861349;36804596;37516794;37875175", "class_list": "", "function": "Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells. Publication Status: Online-Only, [RefSeq, PubMed]; DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis., [RefSeq, PubMed]; MiR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain. Erratum:[Sci Rep. 2023 Aug 16;13(1):13298. doi: 10.1038/s41598-023-40309-z. PMID: 37587209] Publication Status: Online-Only, [RefSeq, PubMed]; Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands., [RefSeq, PubMed]; The results showed a kind of mechanism that sinomenine-induced anaphylactoid reactions were mediated by MRGPRX2 via activating PLC molecular signaling pathways to provoke mast cells Ca(2+) mobilization and degranulation., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9PV62;W8W3J9", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0043303 mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UG50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHD3-1", "uniprot_id": "MTUS2_MOUSE", "mass": 147356.0, "length": 1353, "protein_name": "Microtubule-associated tumor suppressor candidate 2 homolog", "gene_name": "Mtus2", "organism": "Mouse", "refseq_name": "microtubule-associated tumor suppressor candidate 2 homolog isoform a", "refseq_ac": "NP_084196", "gene_names_uniprotkb": "Mtus2; Cazip; Kiaa0774; Tip150", "gene_names_refseq": "5730592G18Rik; A730013O20Rik; C130038G02Rik; Cazip; Gm763; Mtus2; mKIAA0774", "protein_names_uniprotkb": "Microtubule-associated tumor suppressor candidate 2 homolog; Cardiac zipper protein; Microtubule plus-end tracking protein TIP150; Tracking protein of 150 kDa", "protein_names_refseq": "cardiac zipper protein; microtubule plus-end tracking protein TIP150; microtubule-associated tumor suppressor candidate 2 homolog isoform a; microtubule-associated tumor suppressor candidate 2 homolog; tracking protein of 150 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:77521)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;19806667;21183079;21750661;34428180", "class_list": "", "function": "Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity)., [UniProtKB]; These results suggest a role for CAZIP in development and function of the heart and nervous system in vertebrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9EKJ2;Q7TPP7;Q8CHD2;Q9CY74", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0005881 cytoplasmic microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UHD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UN70-1", "uniprot_id": "MRFL_MOUSE", "mass": 101689.0, "length": 904, "protein_name": "Myelin regulatory factor-like protein", "gene_name": "Myrfl", "organism": "Mouse", "refseq_name": "myelin regulatory factor-like protein", "refseq_ac": "NP_001028505", "gene_names_uniprotkb": "Myrfl; Gm239", "gene_names_refseq": "Gm239; Myrfl", "protein_names_uniprotkb": "Myelin regulatory factor-like protein", "protein_names_refseq": "myelin regulatory factor-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:237558)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UN89", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UN70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61830-1", "uniprot_id": "MRC1_MOUSE", "mass": 164981.0, "length": 1456, "protein_name": "Macrophage mannose receptor 1", "gene_name": "Mrc1", "organism": "Mouse", "refseq_name": "macrophage mannose receptor 1 precursor", "refseq_ac": "NP_032651", "gene_names_uniprotkb": "Mrc1", "gene_names_refseq": "CD206; MR; Mrc1", "protein_names_uniprotkb": "Macrophage mannose receptor 1; MMR", "protein_names_refseq": "MMR; macrophage mannose receptor 1 precursor; macrophage mannose receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17533); (R-MMU-1236978)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10748229;11152606;1421407;25428506;34289986;34428180", "class_list": "glycogene", "function": "Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 80, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8C502", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005537 D-mannose binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0010008 endosome membrane", "go_biological_process": "GO:0071222 cellular response to lipopolysaccharide;GO:0006898 receptor-mediated endocytosis;GO:0071346 cellular response to type II interferon;GO:0071353 cellular response to interleukin-4", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61830-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64449-1", "uniprot_id": "MRC2_MOUSE", "mass": 167074.0, "length": 1479, "protein_name": "C-type mannose receptor 2", "gene_name": "Mrc2", "organism": "Mouse", "refseq_name": "C-type mannose receptor 2 precursor", "refseq_ac": "NP_032652", "gene_names_uniprotkb": "Mrc2; Kiaa0709", "gene_names_refseq": "Endo180; Mrc2; mKIAA0709; uPARAP", "protein_names_uniprotkb": "C-type mannose receptor 2; Lectin lambda; Macrophage mannose receptor 2", "protein_names_refseq": "C-type mannose receptor 2 precursor; lectin lambda; macrophage mannose receptor 2; novel lectin", "tax_id": 10090, "disease": "", "pathway": " (mmu:17534); (R-MMU-1236978)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12668656;12835757;12856000;14729061;15967816;19656770;21750661;22645316;30899004;31599954;34112782;34428180;35878760;38953222;8702911", "class_list": "glycogene", "function": "Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs)., [UniProtKB, PubMed, PubMed, PubMed]; Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome., [RefSeq, PubMed]; The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 59, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "A2AAB0;Q6ZQ64;Q8C6P0", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005518 collagen binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0030574 collagen catabolic process;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q64449-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NVG5-1", "uniprot_id": "MREG_MOUSE", "mass": 25010.0, "length": 214, "protein_name": "Melanoregulin", "gene_name": "Mreg", "organism": "Mouse", "refseq_name": "melanoregulin isoform 1", "refseq_ac": "NP_001005423", "gene_names_uniprotkb": "Mreg; Dsu; Gm974; Wdt2", "gene_names_refseq": "Gm974; Mreg; Wdt2; dsu", "protein_names_uniprotkb": "Melanoregulin; Dilute suppressor protein; Whn-dependent transcript 2", "protein_names_refseq": "dilute suppressor protein; melanoregulin isoform 1; whn-dependent transcript 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:381269)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15550542;17260955;19240024;22275436;22753477;22940130;30174147;3410303", "class_list": "", "function": "Mreg contains six alpha helices forming a fishhook-like fold in which positive and negative charges occupy opposite sides of the protein's surface and sandwich a putative, cholesterol recognition sequence (CRAC motif). Mreg containing a point mutation within its CRAC motif still targets to late endosomes/lysosomes, but no longer promotes their microtubule minus end-directed transport., [RefSeq, PubMed]; Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery (PubMed:22275436, PubMed:22940130, PubMed:30174147). Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes (PubMed:15550542, PubMed:22753477, PubMed:3410303). Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center (PubMed:22275436, PubMed:22940130). Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell (PubMed:19240024, PubMed:30174147). Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport (PubMed:30174147). Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (PubMed:19240024). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye (PubMed:19240024). May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031902 late endosome membrane;GO:0042470 melanosome", "go_biological_process": "GO:0090382 phagosome maturation;GO:0043473 pigmentation;GO:0032402 melanosome transport;GO:0048066 developmental pigmentation;GO:0032400 melanosome localization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NVG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P7F1-1", "uniprot_id": "MPP4_MOUSE", "mass": 72001.0, "length": 635, "protein_name": "MAGUK p55 subfamily member 4", "gene_name": "Mpp4", "organism": "Mouse", "refseq_name": "MAGUK p55 subfamily member 4 isoform 1", "refseq_ac": "NP_001158154", "gene_names_uniprotkb": "Mpp4; Dlg6", "gene_names_refseq": "Dlg6; Mpp4", "protein_names_uniprotkb": "MAGUK p55 subfamily member 4; Discs large homolog 6; mDLG6", "protein_names_refseq": "MAGUK p55 subfamily member 4 isoform 1; MAGUK p55 subfamily member 4; discs large homolog 6; mDLG6; membrane palmitoylated protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:227157)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12127943;12384283;12859944;15316081;15558731;15914641;17341488;19233278;21750661;35820727", "class_list": "", "function": "Data suggest that both scaffold proteins PSD95beta and MPP4 are essential for the modulation of PMCA levels at the presynaptic plasma membrane and thereby influence the photoreceptor synaptic calcium handling., [RefSeq, PubMed]; May play a role in retinal photoreceptors development., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the temporal and spatial expression patterns of mouse membrane palmitoylated protein 4 (Mpp4) gene., [RefSeq, PubMed]; Results show that Mpp4 organizes a presynaptic protein complex and has a role in modulating Ca(2+) homeostasis and synaptic transmission in rod photoreceptors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VG45;Q8BTT3;Q8BXM5;Q920P7;Q920P8", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0035418 protein localization to synapse;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6P7F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDI6-1", "uniprot_id": "MINY2_MOUSE", "mass": 65637.0, "length": 601, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-2", "gene_name": "Mindy2", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform 1", "refseq_ac": "NP_766360", "gene_names_uniprotkb": "Mindy2; Fam63b; Kiaa1164", "gene_names_refseq": "B230380D07Rik; Fam63b; Mindy2; mKIAA1164", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-2; 3.4.19.12; Deubiquitinating enzyme MINDY-2; Protein FAM63B", "protein_names_refseq": "deubiquitinating enzyme MINDY-2; family with sequence similarity 63, member B; protein FAM63B; ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform 1; ubiquitin carboxyl-terminal hydrolase MINDY-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235461)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18250455;21183079;21750661;35820727", "class_list": "", "function": "Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Can also bind to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33' and 'Lys-63'. May play a regulatory role at the level of protein turnover., [UniProtKB, UniProtKB]; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q571N1;Q6NSV8;Q7TML6;Q8BK25;Q8BL22;Q8BL47;Q8BZC1", "ec_number_list": "", "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0016807 cysteine-type carboxypeptidase activity;GO:0071795 K11-linked polyubiquitin modification-dependent protein binding;GO:0071796 K6-linked polyubiquitin modification-dependent protein binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PDI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q791T5-1", "uniprot_id": "MTCH1_MOUSE", "mass": 41565.0, "length": 389, "protein_name": "Mitochondrial carrier homolog 1", "gene_name": "Mtch1", "organism": "Mouse", "refseq_name": "mitochondrial carrier homolog 1 isoform 2", "refseq_ac": "NP_001334264", "gene_names_uniprotkb": "Mtch1", "gene_names_refseq": "2310034O17Rik; Mtch1; PSAP", "protein_names_uniprotkb": "Mitochondrial carrier homolog 1; Mitochondrial carrier-like protein 1", "protein_names_refseq": "mitochondrial carrier homolog 1 isoform 2; mitochondrial carrier homolog 1; mitochondrial carrier-like protein 1", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:56462)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16479539;17114649;21750661;22872234;24129315;25428506;30779550;31219806;34203471;34428180;36210013;36288343", "class_list": "", "function": "Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (By similarity). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4W7;Q791V6;Q8R0T0;Q8R1T8;Q8R2T2;Q9QZA5;Q9QZP4", "ec_number_list": "", "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q791T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN51-1", "uniprot_id": "MRGB8_MOUSE", "mass": 37892.0, "length": 330, "protein_name": "Mas-related G protein-coupled receptor member B8", "gene_name": "Mrgprb8", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member B8", "refseq_ac": "NP_997422", "gene_names_uniprotkb": "Mrgprb8; Mrgb8", "gene_names_refseq": "MrgB8; Mrgprb8", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B8", "protein_names_refseq": "mas-related G-protein coupled receptor member B8", "tax_id": 10090, "disease": "", "pathway": " (mmu:404240)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12909716", "class_list": "", "function": "Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RR10", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TN51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TT41-1", "uniprot_id": "MOXD2_MOUSE", "mass": 69397.0, "length": 619, "protein_name": "DBH-like monooxygenase protein 2", "gene_name": "Moxd2", "organism": "Mouse", "refseq_name": "DBH-like monooxygenase protein 2 precursor", "refseq_ac": "NP_647457", "gene_names_uniprotkb": "Moxd2; Dbhl1; Dbhl", "gene_names_refseq": "Dbhl1; Moxd2", "protein_names_uniprotkb": "DBH-like monooxygenase protein 2; 1.14.17.-; Dopamine-beta-hydroxylase-like protein", "protein_names_refseq": "DBH-like monooxygenase protein 2 precursor; DBH-like monooxygenase protein 2; dopamine beta-hydroxylase-like 1; dopamine-beta-hydroxylase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:194357)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11160223;11397006;15337741", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91XT2", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0042420 dopamine catabolic process;GO:0006589 octopamine biosynthetic process;GO:0042421 norepinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TT41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TA6-1", "uniprot_id": "MTMRC_MOUSE", "mass": 85516.0, "length": 747, "protein_name": "Myotubularin-related protein 12", "gene_name": "Mtmr12", "organism": "Mouse", "refseq_name": "myotubularin-related protein 12 isoform 1", "refseq_ac": "NP_766546", "gene_names_uniprotkb": "Mtmr12; Kiaa1682", "gene_names_refseq": "3Pap; 4932703C11; C730015A02Rik; Mtmr12; Pip3ap; mKIAA1682", "protein_names_uniprotkb": "Myotubularin-related protein 12; Inactive phosphatidylinositol 3-phosphatase 12", "protein_names_refseq": "inactive phosphatidylinositol 3-phosphatase 12; myotubularin-related protein 12 isoform 1; phosphatidylinositol-3 phosphate 3-phosphatase adaptor subunit; phosphatidylinositol-3-phosphatase associated protein", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:268783); (R-MMU-1660516)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23818870;25428506;30084848;31599954;37828378", "class_list": "", "function": "Acts as an adapter for the myotubularin-related phosphatases (PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870)., [UniProtKB, PubMed]; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVX4;Q8C0P1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030017 sarcomere;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80TA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UN9-1", "uniprot_id": "MOD5_MOUSE", "mass": 52437.0, "length": 467, "protein_name": "tRNA dimethylallyltransferase", "gene_name": "Trit1", "organism": "Mouse", "refseq_name": "tRNA dimethylallyltransferase precursor", "refseq_ac": "NP_080149", "gene_names_uniprotkb": "Trit1; Ipt", "gene_names_refseq": "2310075G14Rik; IPPT; IPT; MOD5; Trit1", "protein_names_uniprotkb": "tRNA dimethylallyltransferase; 2.5.1.75; IPP transferase; IPPT; IPTase; Isopentenyl-diphosphate:tRNA isopentenyltransferase; tRNA isopentenyltransferase", "protein_names_refseq": "IPP transferase; IPTase; isopentenyl-diphosphate:tRNA isopentenyltransferase; tRNA dimethylallyltransferase precursor; tRNA dimethylallyltransferase, mitochondrial; tRNA isopentenyltransferase, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 35 (Disease Ontology:DOID:0111464); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:66966)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23289710;31219806;34768885", "class_list": "", "function": "Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:23289710). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (By similarity). TRIT1 is therefore required for selenoprotein expression (PubMed:23289710)., [UniProtKB, UniProtKB, PubMed]; Knockdown of Trit1 reduces expression of selenoproteins., [RefSeq, PubMed]; The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ARS6;Q9D1H5", "ec_number_list": "2.5.1.75", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0052381 tRNA dimethylallyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006400 tRNA modification;GO:0070900 mitochondrial tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80UN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XL7-1", "uniprot_id": "MPPE1_MOUSE", "mass": 46012.0, "length": 396, "protein_name": "Metallophosphoesterase 1", "gene_name": "Mppe1", "organism": "Mouse", "refseq_name": "metallophosphoesterase 1 isoform 1", "refseq_ac": "NP_766218", "gene_names_uniprotkb": "Mppe1; Pgap5", "gene_names_refseq": "Mppe1; Pgap5", "protein_names_uniprotkb": "Metallophosphoesterase 1; 3.1.-.-; Post-GPI attachment to proteins factor 5", "protein_names_refseq": "metallophosphoesterase 1 isoform 1; post-GPI attachment to proteins factor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:225651)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180", "class_list": "", "function": "Metallophosphoesterase that catalyzes the removal of a side-chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI-anchor protein intermediate. Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9I6;Q3TYP9;Q3U4F5;Q8BLU5", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0062050 GPI-mannose ethanolamine phosphate phosphodiesterase activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070971 endoplasmic reticulum exit site;GO:0016020 membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80XL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810V0-1", "uniprot_id": "MPP10_MOUSE", "mass": 78735.0, "length": 681, "protein_name": "U3 small nucleolar ribonucleoprotein protein MPP10", "gene_name": "Mphosph10", "organism": "Mouse", "refseq_name": "U3 small nucleolar ribonucleoprotein MPP10", "refseq_ac": "NP_080759", "gene_names_uniprotkb": "Mphosph10", "gene_names_refseq": "2810453H10Rik; 5730405D16Rik; Mphosph10", "protein_names_uniprotkb": "U3 small nucleolar ribonucleoprotein protein MPP10; M phase phosphoprotein 10", "protein_names_refseq": "U3 small nucleolar ribonucleoprotein MPP10; U3 small nucleolar ribonucleoprotein protein MPP10; m phase phosphoprotein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:67973); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17242355;19144319;21183079;25428506;31599954;34428180", "class_list": "", "function": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QM78", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex;GO:0034457 Mpp10 complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q810V0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGC3-1", "uniprot_id": "MOT12_MOUSE", "mass": 53152.0, "length": 486, "protein_name": "Monocarboxylate transporter 12", "gene_name": "Slc16a12", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 12", "refseq_ac": "NP_766426", "gene_names_uniprotkb": "Slc16a12; Mct12", "gene_names_refseq": "3230401A21; MCT 12; Slc16a12", "protein_names_uniprotkb": "Monocarboxylate transporter 12; MCT 12; Solute carrier family 16 member 12", "protein_names_refseq": "monocarboxylate transporter 12", "tax_id": 10090, "disease": "cataract 47 (Disease Ontology:DOID:0070353)", "pathway": " (mmu:240638)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21778275;26376857", "class_list": "", "function": "A model whereby the SLC16A12 (c.643C>T) mutation causes juvenile cataract by a defect in protein trafficking rather than by haploinsufficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14CF9;Q14DR7", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005308 creatine transmembrane transporter activity;GO:0015292 uniporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0046449 creatinine metabolic process;GO:0015881 creatine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIA3-1", "uniprot_id": "MKX_MOUSE", "mass": 39401.0, "length": 353, "protein_name": "Homeobox protein Mohawk", "gene_name": "Mkx", "organism": "Mouse", "refseq_name": "homeobox protein Mohawk", "refseq_ac": "NP_808263", "gene_names_uniprotkb": "Mkx", "gene_names_refseq": "9430023B20Rik; Irxl1; Mkx", "protein_names_uniprotkb": "Homeobox protein Mohawk", "protein_names_refseq": "homeobox protein Mohawk; iroquois homeobox protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:210719)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16408284;16426902;16824806;19235719;21750661;31219806;34816492;36411329;38732238", "class_list": "", "function": "Involvement of homeobox transcription factor Mohawk in palatogenesis., [RefSeq, PubMed]; Irxl1 is a newly identified highly divergent member of the Irx gene family with specific expression patterns in embryogenesis., [RefSeq, PubMed]; May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation., [UniProtKB, PubMed]; Mohawk can repress transcription through recruitment of the Sin3A/HDAC co-repressor complex, [RefSeq, PubMed]; Mohawk impedes angiofibrosis by preventing the differentiation of tendon stem/progenitor cells into myofibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Mohawk is an important regulator of vertebrate development., [RefSeq, PubMed]; The Transcription Factor Mohawk Facilitates Skeletal Muscle Repair via Modulation of the Inflammatory Environment. Publication Status: Online-Only, [RefSeq, PubMed]; The developmental expression pattern indicates that Irxl1 is a good candidate gene for the Twirler gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002932 tendon sheath development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BIA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJS8-1", "uniprot_id": "MTBP_MOUSE", "mass": 100314.0, "length": 894, "protein_name": "Mdm2-binding protein", "gene_name": "Mtbp", "organism": "Mouse", "refseq_name": "mdm2-binding protein isoform 2", "refseq_ac": "NP_001161722", "gene_names_uniprotkb": "Mtbp", "gene_names_refseq": "MDM2BP; Mtbp", "protein_names_uniprotkb": "Mdm2-binding protein; mMTBP", "protein_names_refseq": "Mdm2, transformed 3T3 cell double minute p53 binding protein; mMTBP; mdm2-binding protein isoform 2; mdm2-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:105837); (R-MMU-9766229)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10906133;15632057;17906694;21183079;21750661;27803394;34428180", "class_list": "", "function": "May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells., [UniProtKB, PubMed, PubMed]; Mtbp haploinsufficiency significantly increased longevity and maximal survival in mice. Reduced levels of Mtbp did not alter locomotor activity, litter size, or body size, but Mtbp heterozygous mice did exhibit elevated markers of metabolism, particularly in the liver. Mtbp(+/-) mice also had a significant delay in spontaneous cancer development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VU3;Q8BTU9;Q8BTW0;Q99K25;Q9ER61", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000776 kinetochore;GO:0000785 chromatin", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045839 negative regulation of mitotic nuclear division;GO:0007089 traversing start control point of mitotic cell cycle;GO:0034501 protein localization to kinetochore;GO:0031396 regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BJS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPB0-1", "uniprot_id": "MOB1B_MOUSE", "mass": 25091.0, "length": 216, "protein_name": "MOB kinase activator 1B", "gene_name": "Mob1b", "organism": "Mouse", "refseq_name": "MOB kinase activator 1B", "refseq_ac": "NP_081011", "gene_names_uniprotkb": "Mob1b; Mobkl1a", "gene_names_refseq": "1110003E08Rik; B230364F10; Mob1b; Mobkl1a", "protein_names_uniprotkb": "MOB kinase activator 1B; Mob1 homolog 1A; Mps one binder kinase activator-like 1A", "protein_names_refseq": "MOB kinase activator 1B; MOB1, Mps One Binder kinase activator-like 1A; mob1 homolog 1A; mps one binder kinase activator-like 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68473); (R-MMU-2028269)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "18328708;19073936;20173027;23143302;31219806;34428180;34725466", "class_list": "", "function": "Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity)., [UniProtKB]; EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Publication Status: Online-Only, [RefSeq, PubMed]; MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway., [RefSeq, PubMed]; MOBKL1A/MOBKL1B phosphorylation, by MST1 and MST2, is sufficient to inhibit proliferation through actions at several points in the cell cycle., [RefSeq, PubMed]; Mst1/2-catalyzed MOBKL1A/B phosphorylation slows proliferation and is therefore a likely contributor to the anti-proliferative action of Mst1 in naive T cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019209 kinase activator activity;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035329 hippo signaling;GO:0031952 regulation of protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BPB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C436-1", "uniprot_id": "MT21D_MOUSE", "mass": 25535.0, "length": 228, "protein_name": "Protein N-lysine methyltransferase METTL21D", "gene_name": "Vcpkmt", "organism": "Mouse", "refseq_name": "protein N-lysine methyltransferase METTL21D isoform 2", "refseq_ac": "NP_001028408", "gene_names_uniprotkb": "Vcpkmt; Gm71; Mettl21d", "gene_names_refseq": "Gm71; Mettl21d; Mettl221d; VCP-KMT; Vcpkmt", "protein_names_uniprotkb": "Protein N-lysine methyltransferase METTL21D; 2.1.1.-; Methyltransferase-like protein 21D; VCP lysine methyltransferase; VCP-KMT; Valosin-containing protein lysine methyltransferase", "protein_names_refseq": "VCP lysine methyltransferase; methyltransferase like 21D; methyltransferase-like protein 21D; protein N-lysine methyltransferase METTL21D isoform 2; protein N-lysine methyltransferase METTL21D; protein-lysine methyltransferase METTL21D; valosin-containing protein lysine methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:207965); (R-MMU-8876725)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;26544960", "class_list": "", "function": "Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice Publication Status: Online-Only, [RefSeq, PubMed]; Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSP0;Q3UML0", "ec_number_list": "2.1.1.-;2.1.1.359;3.6.4.6;2.1.1.372", "go_molecular_function": "GO:0051117 ATPase binding;GO:0008276 protein methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032780 negative regulation of ATP-dependent activity;GO:0018022 peptidyl-lysine methylation;GO:0018023 peptidyl-lysine trimethylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5T4-1", "uniprot_id": "MORN3_MOUSE", "mass": 27881.0, "length": 241, "protein_name": "MORN repeat-containing protein 3", "gene_name": "Morn3", "organism": "Mouse", "refseq_name": "MORN repeat-containing protein 3 isoform 2", "refseq_ac": "NP_001334385", "gene_names_uniprotkb": "Morn3", "gene_names_refseq": "4930438O03Rik; Morn3", "protein_names_uniprotkb": "MORN repeat-containing protein 3", "protein_names_refseq": "MORN repeat-containing protein 3 isoform 2; MORN repeat-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74890)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25248657", "class_list": "", "function": "Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (By similarity). May play a role in the regulation of spermatogenesis (PubMed:25248657)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; MORN3 is another regulator for spermatogenesis, probably together with MEIG1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VE21;Q9D5H6", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0072331 signal transduction by p53 class mediator;GO:1901797 negative regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C5T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5W4-1", "uniprot_id": "MOR2B_MOUSE", "mass": 117186.0, "length": 1022, "protein_name": "ATPase MORC2B", "gene_name": "Morc2b", "organism": "Mouse", "refseq_name": "ATPase MORC2B", "refseq_ac": "NP_808387", "gene_names_uniprotkb": "Morc2b; Tce6", "gene_names_refseq": "4932411A10Rik; Morc2b; Tce6", "protein_names_uniprotkb": "ATPase MORC2B; 3.6.1.-; MORC family CW-type zinc finger protein 2B; TCE6", "protein_names_refseq": "ATPase MORC2B; MORC family CW-type zinc finger protein 2B; Morc-like protein", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease axonal type 2Z (Disease Ontology:DOID:0110181)", "pathway": " (mmu:240069)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15112104;25428506;29329290;30084848;30779550;36210013;40885482", "class_list": "", "function": "ATP-dependent chromatin remodeler required for chromosomal synapsis and meiotic recombination in males and females., [UniProtKB, PubMed]; Morc2b, a relatively recent gene, has evolved an essential role in meiosis and fertility. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B8JK02;Q8CG24", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006974 DNA damage response;GO:0007129 homologous chromosome pairing at meiosis;GO:1990918 double-strand break repair involved in meiotic recombination;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C5W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIP3-1", "uniprot_id": "MRGX1_MOUSE", "mass": 36810.0, "length": 322, "protein_name": "Mas-related G protein-coupled receptor member X1", "gene_name": "Mrgprx1", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member X1", "refseq_ac": "NP_997423", "gene_names_uniprotkb": "Mrgprx1; Mrgc11; Mrgprc11", "gene_names_refseq": "MrgC11; Mrgprc11; Mrgprx1", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member X1; Mas-related G protein-coupled receptor member C11; Sensory neuron-specific G protein-coupled receptor 1", "protein_names_refseq": "MAS-related GPR, member C11; mas-related G-protein coupled receptor member C11; mas-related G-protein coupled receptor member X1; sensory neuron-specific G-protein coupled receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:404242)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12397184;20004959;26216096;28768771;31350433;33358893;33876765;39243765", "class_list": "", "function": "G protein-coupled receptor specifically expressed in sensory neurons of dorsal root ganglion, and which is involved in itch perception and pain transmission (PubMed:12397184, PubMed:20004959, PubMed:31350433, PubMed:33358893, PubMed:33876765, PubMed:39243765). Specifically activated by a variety of enkephalin (PENK) neuropeptides, such as BAM22 and BAM8-22, which induce itch in a histamine-independent manner (PubMed:31350433, PubMed:39243765). Activated by some tick defensins, such as I.persulcatus Def1 and I.ricinus Def2, evoking itch (PubMed:33358893). Also activated following cleavage by cathepsin S (CTSS) and dust mite cysteine protease Der p1 (PubMed:26216096, PubMed:28768771). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:12397184). MRGPRX1 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, leading to sensitize TRPV1 in pruriceptors, while G(i) coupling mediates inhibition of adenylate cyclase activity (PubMed:12397184). Activation of MRGPRX1 in the peripheral nervous system elicits itch, evoking scratching (PubMed:31350433, PubMed:33876765). MRGPRX1 activation in sensory neurons of the nasal mucosa mediates sneezing responses to irritants or influenza-virus (PubMed:39243765). Activation in the central nervous system dampens chronic pain: BAM8-22-binding at the central terminals prevents pain signals passing to spinal cord neurons, attenuating spinal nociceptive transmission (By similarity). Activation by CXCL17 induces chemotactic movement (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MrgprC11(+) sensory neurons mediate glabrous skin itch., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0038182 G protein-coupled bile acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1904057 negative regulation of sensory perception of pain;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CIP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R404-1", "uniprot_id": "MIC13_MOUSE", "mass": 13373.0, "length": 119, "protein_name": "MICOS complex subunit MIC13", "gene_name": "Micos13", "organism": "Mouse", "refseq_name": "MICOS complex subunit MIC13 precursor", "refseq_ac": "NP_694792", "gene_names_uniprotkb": "Micos13; Mic13; Qil1", "gene_names_refseq": "2410015M20Rik; Mic13; Micos13; QIL1; sr104", "protein_names_uniprotkb": "MICOS complex subunit MIC13", "protein_names_refseq": "MICOS complex subunit MIC13 precursor; MICOS complex subunit MIC13; protein QIL1", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 37 (Disease Ontology:DOID:0111499)", "pathway": " (mmu:224904)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;36288343", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCM5-1", "uniprot_id": "MUL1_MOUSE", "mass": 39835.0, "length": 352, "protein_name": "Mitochondrial ubiquitin ligase activator of NFKB 1", "gene_name": "Mul1", "organism": "Mouse", "refseq_name": "mitochondrial ubiquitin ligase activator of NFKB 1", "refseq_ac": "NP_080965", "gene_names_uniprotkb": "Mul1; Gide", "gene_names_refseq": "0610009K11Rik; Gide; Mul1; Tnrip-1", "protein_names_uniprotkb": "Mitochondrial ubiquitin ligase activator of NFKB 1; 2.3.2.27; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; Protein Hades; RING-type E3 ubiquitin transferase NFKB 1", "protein_names_refseq": "E3 ubiquitin ligase; E3 ubiquitin-protein ligase MUL1; RING-type E3 ubiquitin transferase NFKB 1; growth inhibition and death E3 ligase; mitochondrial ubiquitin ligase activator of NFKB 1; protein Hades", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:68350); (R-MMU-5689880); (R-MMU-8951664); (R-MMU-9755511)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "18082624;18591963;24709290;24898855;26018823;34428180;37962001;38639871", "class_list": "", "function": "Exhibits weak E3 ubiquitin-protein ligase activity (By similarity). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation (By similarity). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-27' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (By similarity). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (By similarity). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (By similarity). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (By similarity). Inhibits cell growth (By similarity). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (By similarity). Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity). Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity)., [UniProtKB, UniProtKB, PubMed]; Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy., [RefSeq, PubMed]; Increased ROS levels in mitochondrial outer membrane protein Mul1-deficient oocytes result in abnormal preimplantation embryogenesis., [RefSeq, PubMed]; MAPL loss dysregulates bile and liver metabolism in mice., [RefSeq, PubMed]; MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy, [RefSeq, PubMed]; These results suggest that Tnrip-1 is a testis-specific and GCNF-interacting protein which may be involved in the modulation of GCNF-mediated gene transcription in spermatogenic cells within the testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AM82;A2AM84;B5M498;Q3TDK4;Q8BHF2;Q9DCV9", "ec_number_list": "5.2.1.8;2.3.2.27;2.3.2.32;3.4.19.12;3.6.5.-;3.1.1.29;3.4.24.56", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0002039 p53 binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:1903861 positive regulation of dendrite extension;GO:0050689 negative regulation of defense response to virus by host;GO:0016925 protein sumoylation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE04-1", "uniprot_id": "MOB3B_MOUSE", "mass": 25519.0, "length": 216, "protein_name": "MOB kinase activator 3B", "gene_name": "Mob3b", "organism": "Mouse", "refseq_name": "MOB kinase activator 3B", "refseq_ac": "NP_835162", "gene_names_uniprotkb": "Mob3b; Mobkl2b", "gene_names_refseq": "8430436F23Rik; A430018A01Rik; Mob3b; Mobkl2b", "protein_names_uniprotkb": "MOB kinase activator 3B; Mob1 homolog 2b; Mps one binder kinase activator-like 2B", "protein_names_refseq": "MOB kinase activator 3B; MOB1 (Mps One Binder) kinase activator-like 2B; mob1 homolog 2b; mps one binder kinase activator-like 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:214944)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2L2;Q8BU65", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035330 regulation of hippo signaling;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VE04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE19-1", "uniprot_id": "MIOS_MOUSE", "mass": 98335.0, "length": 875, "protein_name": "GATOR2 complex protein MIOS", "gene_name": "Mios", "organism": "Mouse", "refseq_name": "GATOR2 complex protein MIOS", "refseq_ac": "NP_663349", "gene_names_uniprotkb": "Mios", "gene_names_refseq": "Mios", "protein_names_uniprotkb": "GATOR2 complex protein MIOS", "protein_names_refseq": "GATOR complex protein MIOS; GATOR2 complex protein MIOS; WD repeat-containing protein mio; missing oocyte, meiosis regulator, homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:252875); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;31219806;35022234", "class_list": "", "function": "As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:35022234). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (By similarity). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (By similarity). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (By similarity). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (By similarity). Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex (By similarity). The GATOR2 complex is required for brain myelination (PubMed:35022234)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QM00", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030054 cell junction;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032289 central nervous system myelin formation;GO:0031669 cellular response to nutrient levels;GO:0034198 cellular response to amino acid starvation;GO:0031503 protein-containing complex localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VE19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VR7-1", "uniprot_id": "MLP3A_MOUSE", "mass": 14272.0, "length": 121, "protein_name": "Microtubule-associated protein 1 light chain 3 alpha", "gene_name": "Map1lc3a", "organism": "Mouse", "refseq_name": "microtubule-associated protein 1 light chain 3 alpha", "refseq_ac": "NP_080011", "gene_names_uniprotkb": "Map1lc3a", "gene_names_refseq": "1010001H21Rik; 4922501H04Rik; LC3a; LC3; Map1lc3a", "protein_names_uniprotkb": "Microtubule-associated protein 1 light chain 3 alpha; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; Microtubule-associated proteins 1A/1B light chain 3A", "protein_names_refseq": "MAP1 light chain 3-like protein 1; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; autophagy-related protein LC3 A; autophagy-related ubiquitin-like modifier LC3 A; microtubule-associated protein 1 light chain 3 alpha; microtubule-associated proteins 1A/1B light chain 3A", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); liver cirrhosis (Disease Ontology:DOID:5082); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:66734); (R-MMU-1632852); (R-MMU-5205685); (R-MMU-8934903)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11266458;12207896;14530254;33300544;33795848;34338405", "class_list": "", "function": "Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVS1;Q9DC74", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0010288 response to lead ion;GO:0007254 JNK cascade;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91VR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WW2-1", "uniprot_id": "MRGA4_MOUSE", "mass": 35682.0, "length": 313, "protein_name": "Mas-related G protein-coupled receptor member A4", "gene_name": "Mrgpra4", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member A4", "refseq_ac": "NP_705744", "gene_names_uniprotkb": "Mrgpra4; Mrga4", "gene_names_refseq": "Mgrg10; MrgA4; Mrgpra4", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A4; RF-amide G protein-coupled receptor", "protein_names_refseq": "Mas-related G protein-coupled receptor g10; MrgA4 RF-amide G protein-coupled receptor; RF-amide G-protein coupled receptor; mas-related G-protein coupled receptor member A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:235854)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11551509", "class_list": "", "function": "Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1RLL1", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0008188 neuropeptide receptor activity;GO:1990595 mast cell secretagogue receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91WW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XS1-1", "uniprot_id": "MTMR4_MOUSE", "mass": 132885.0, "length": 1190, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4", "gene_name": "Mtmr4", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 isoform 1", "refseq_ac": "NP_573478", "gene_names_uniprotkb": "Mtmr4", "gene_names_refseq": "ESTM44; FYVE-DSP2; Mtmr4; ZFYVE11; mKIAA0647", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4; 3.1.3.95; Myotubularin-related protein 4; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "FYVE zinc finger phosphatase; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:170749); (R-MMU-1660516); (R-MMU-1660517); (R-MMU-2173788)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "16075062;17242355;18250455;21183079;21750661;22872234;26495903;26740625;28935714;30944173;31543504;33725478;34428180;35820727", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes. Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation. By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response. Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis. Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes., [UniProtKB, UniProtKB]; MTMR4 negatively regulated the phagocytosis of IgG-opsonized particles, indicating that MTMR4 inhibits FcgammaR-mediated phagocytosis, and was dynamically recruited to phagosomes of macrophages during phagocytosis., [RefSeq, PubMed]; These results suggest that MTMR3 and MTMR4 regulate the production of PtdIns3P, which plays a critical role in suppressing DNA-mediated innate immune responses via modulating STING trafficking., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ND06;Q5ND08", "ec_number_list": "3.1.3.67;3.1.3.86;3.1.3.95;3.1.3.36;3.1.3.-;3.1.3.64", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019903 protein phosphatase binding;GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0030514 negative regulation of BMP signaling pathway;GO:0006661 phosphatidylinositol biosynthetic process;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91XS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZB7-1", "uniprot_id": "MRGRE_MOUSE", "mass": 34588.0, "length": 310, "protein_name": "Mas-related G protein-coupled receptor member E", "gene_name": "Mrgpre", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member E", "refseq_ac": "NP_780743", "gene_names_uniprotkb": "Mrgpre; Ebrt3; Mrge", "gene_names_refseq": "C130069N09Rik; Ebrt3; Mgrf; MrgE; Mrgpre", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member E; Evolutionary breakpoint transcript 3 protein", "protein_names_refseq": "G protein-coupled receptor MrgE; Mas-related G protein-coupled receptor f; evolutionary breakpoint transcript 3 protein; mas-related G-protein coupled receptor member E", "tax_id": 10090, "disease": "", "pathway": " (mmu:244238)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11551509;18197975;21912971;34647371;40446798", "class_list": "", "function": "G protein-coupled receptor for L-tryptophanocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome, which regulates glucose homeostasis (PubMed:40446798). Expressed in enteroendocrine L cells of the gut epithelium: Trp-CA binding causes a conformation change that triggers signaling via G(s) G protein, mediating activation of adenylate cyclase activity (PubMed:40446798). In addition to G(s), MRGPRE also associates with beta-arrestin-1 (ARRB1), promoting phosphorylation of ALDOA (PubMed:40446798). Both G(s) and beta-arrestin-1 signaling pathways improves glucose tolerance by enhancing GLP-1 secretion (PubMed:40446798)., [UniProtKB, PubMed]; Mas-related G protein-coupled receptor D is involved in modulation of murine gastrointestinal motility., [RefSeq, PubMed]; The data suggests that MrgE may play a role in selective pain behavioural responses in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The number of enteric neurons expressing MrgE and MrgF receptors was significantly reduced during intestinal schistosomiasis and ileitis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q711I9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038182 G protein-coupled bile acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0001678 intracellular glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZB8-1", "uniprot_id": "MRGRD_MOUSE", "mass": 36126.0, "length": 321, "protein_name": "Mas-related G protein-coupled receptor member D", "gene_name": "Mrgprd", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member D", "refseq_ac": "NP_987075", "gene_names_uniprotkb": "Mrgprd; Gm499; Mrgd", "gene_names_refseq": "Gm499; Mgrd; MrgD; Mrgprd; TGR7", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member D; Beta-alanine receptor; G protein-coupled receptor TGR7", "protein_names_refseq": "G protein-coupled receptor MrgD; G-protein coupled receptor TGR7; Mas-related G protein-coupled receptor d; beta-alanine receptor; mas-related G-protein coupled receptor member D", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:211578)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11551509;15037633;15629699;23446738;27217404;29443552;29792841;30339496;33765440;34901497;35820727;35979816;36879552;38147415", "class_list": "", "function": "G protein-coupled receptor that acts as a mediator of peripheral pain and itch sensations (PubMed:23446738, PubMed:29443552, PubMed:29792841, PubMed:30339496, PubMed:38147415). Activated by various ligands, such as beta-alanine, beta-aminoisobutyrate, angiotensin 1-7, alamandine and allantoin, causing a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:23446738, PubMed:27217404, PubMed:29443552, PubMed:29792841, PubMed:30339496, PubMed:36879552). MRGPRD is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity (By similarity). MRGPRD is specifically expressed in neurons that innervate the epidermis and acts as a key mediator of skin stimuli, such as itch, pain and mechanical stimuli (PubMed:15629699, PubMed:33765440). Required to maintain skin homeostasis in response to irritant dermatitis by initiating a signaling that promotes glutamate release, inhibiting mast cell hyperresponsiveness and skin inflammation (PubMed:33765440). Required to prevent cardiomyocyte hypertrophy following activation by alamandine, a decarboxylation product of angiotensin 1-7 (PubMed:29443552, PubMed:30339496). Acts as a receptor for allantoin in dorsal root ganglion neurons, eliciting chronic itch (pruritus) (PubMed:36879552)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91ZB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZC0-1", "uniprot_id": "MRGB4_MOUSE", "mass": 36338.0, "length": 321, "protein_name": "Mas-related G protein-coupled receptor member B4", "gene_name": "Mrgprb4", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member B4", "refseq_ac": "NP_991364", "gene_names_uniprotkb": "Mrgprb4; Mrgb4", "gene_names_refseq": "MrgB4; Mrgprb4", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B4", "protein_names_refseq": "MrgB4 G protein-coupled receptor; mas-related G-protein coupled receptor member B4", "tax_id": 10090, "disease": "", "pathway": " (mmu:233230)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11551509", "class_list": "", "function": "Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3B811", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZC4-1", "uniprot_id": "MRGA8_MOUSE", "mass": 35004.0, "length": 305, "protein_name": "Mas-related G protein-coupled receptor member A8", "gene_name": "Mrgpra8", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member A8", "refseq_ac": "NP_997419", "gene_names_uniprotkb": "Mrgpra8; Mrga8", "gene_names_refseq": "MrgA8; Mrga4; Mrgpra4; Mrgpra8", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A8", "protein_names_refseq": "Mas-related G-protein coupled receptor member A4; RF-amide G-protein coupled receptor; mas-related G-protein coupled receptor member A8", "tax_id": 10090, "disease": "", "pathway": " (mmu:404237)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11551509", "class_list": "", "function": "Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZC7-1", "uniprot_id": "MRGA5_MOUSE", "mass": 35095.0, "length": 304, "protein_name": "Mas-related G protein-coupled receptor member A5", "gene_name": "Mrgpra5", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member A5", "refseq_ac": "NP_997417", "gene_names_uniprotkb": "Mrgpra5; Mrga5", "gene_names_refseq": "MrgA5; Mrgpra5", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A5", "protein_names_refseq": "mas-related G-protein coupled receptor member A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:404235)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11551509", "class_list": "", "function": "Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920C4-1", "uniprot_id": "MS4A3_MOUSE", "mass": 22872.0, "length": 213, "protein_name": "Membrane-spanning 4-domains subfamily A member 3", "gene_name": "Ms4a3", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 3", "refseq_ac": "NP_573509", "gene_names_uniprotkb": "Ms4a3; Htm4", "gene_names_refseq": "HTm4; Ms4a3", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 3; HTm4; Hematopoietic-specific transmembrane protein 4", "protein_names_refseq": "haematopoietic cell-specific transmembrane-4; hematopoietic-specific transmembrane protein 4; membrane-spanning 4-domains subfamily A member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:170813); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11401424;11488981;15704002", "class_list": "", "function": "Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) (By similarity)., [UniProtKB]; Murine HTm4 is predominantly a hematopoietic protein and highly expressed in the developing and adult murine nervous system., [RefSeq, PubMed]; This gene encodes a member of the membrane-spanning-four (MS4) protein group, that contain a four-transmembrane protein structure. This gene is expressed in developing hematopoietic cells and has also been observed in some regions of the adult brain. Expression of the human ortholog of this gene has also been observed in some human cancer cell lines. This protein may play a role in cell cycle regulation, and interactions have been demonstrated between Ms4a3 and KAP phosphatase. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MX6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920Q6-1", "uniprot_id": "MSI2H_MOUSE", "mass": 36939.0, "length": 346, "protein_name": "RNA-binding protein Musashi homolog 2", "gene_name": "Msi2", "organism": "Mouse", "refseq_name": "RNA-binding protein Musashi homolog 2 isoform 1", "refseq_ac": "NP_473384", "gene_names_uniprotkb": "Msi2; Msi2h", "gene_names_refseq": "1700105C15Rik; Msi2h; Msi2", "protein_names_uniprotkb": "RNA-binding protein Musashi homolog 2; Musashi-2", "protein_names_refseq": "Musashi2; RNA-binding protein Musashi homolog 2 isoform 1; RNA-binding protein Musashi homolog 2; musashi-2", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306)", "pathway": " (mmu:76626); (R-MMU-9013418)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11588182;12407178;12923295;21750661;24129315;37507081;38373797", "class_list": "", "function": "Data suggest that msi1 and msi2 are cooperatively involved in the proliferation and maintenance of CNS stem cell populations, [RefSeq, PubMed]; RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system., [UniProtKB, PubMed, PubMed]; The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ90;Q920Q7", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0003727 single-stranded RNA binding;GO:0008266 poly(U) RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0007417 central nervous system development;GO:0048864 stem cell development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q920Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921Y0-1", "uniprot_id": "MOB1A_MOUSE", "mass": 25080.0, "length": 216, "protein_name": "MOB kinase activator 1A", "gene_name": "Mob1a", "organism": "Mouse", "refseq_name": "MOB kinase activator 1A isoform a", "refseq_ac": "NP_663546", "gene_names_uniprotkb": "Mob1a; Mobk1b; Mobkl1b", "gene_names_refseq": "4022402H07Rik; MOB1; MOB4B; Mob1a; Mobk1b; Mobkl1b", "protein_names_uniprotkb": "MOB kinase activator 1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B", "protein_names_refseq": "MOB kinase activator 1A isoform a; MOB1, Mps One Binder kinase activator-like 1B; mob1 homolog 1B; mps one binder kinase activator-like 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:232157); (R-MMU-2028269)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;23143302;25428506;30084848;30779550;31219806;34203471;34428180;34725466", "class_list": "", "function": "Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity)., [UniProtKB]; EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Publication Status: Online-Only, [RefSeq, PubMed]; MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJA6;Q8C194;Q8C1C7", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q921Y0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LX5-1", "uniprot_id": "MMTA2_MOUSE", "mass": 29299.0, "length": 260, "protein_name": "Multiple myeloma tumor-associated protein 2 homolog", "gene_name": "Mmtag2", "organism": "Mouse", "refseq_name": "multiple myeloma tumor-associated protein 2 homolog", "refseq_ac": "NP_077172", "gene_names_uniprotkb": "Mmtag2", "gene_names_refseq": "2310033P09Rik; Mmtag2", "protein_names_uniprotkb": "Multiple myeloma tumor-associated protein 2 homolog", "protein_names_refseq": "multiple myeloma tumor-associated protein 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67862); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSK6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99LX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MT8-1", "uniprot_id": "MRGRH_MOUSE", "mass": 36911.0, "length": 321, "protein_name": "Mas-related G protein-coupled receptor member H", "gene_name": "Mrgprh", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member H", "refseq_ac": "NP_109651", "gene_names_uniprotkb": "Mrgprh; Gpr90; Mrgh", "gene_names_refseq": "Gpr90; Mgrb; MrgH; Mrgprh", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member H; G protein-coupled receptor 90", "protein_names_refseq": "G protein-coupled receptor 90; G-protein coupled receptor GPR90; Mas-related G protein-coupled receptor b; mas-related G-protein coupled receptor member H", "tax_id": 10090, "disease": "", "pathway": " (mmu:80978)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11273702;31599954", "class_list": "", "function": "Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q149S2", "ec_number_list": "", "go_molecular_function": "GO:0001595 angiotensin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99MT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQL0-1", "uniprot_id": "MT21A_MOUSE", "mass": 24286.0, "length": 218, "protein_name": "Protein N-lysine methyltransferase METTL21A", "gene_name": "Mettl21A", "organism": "Mouse", "refseq_name": "protein N-lysine methyltransferase METTL21A", "refseq_ac": "NP_080240", "gene_names_uniprotkb": "Mettl21A; Fam119a", "gene_names_refseq": "2310038H17Rik; Fam119a; Mettl21a", "protein_names_uniprotkb": "Protein N-lysine methyltransferase METTL21A; 2.1.1.-; Methyltransferase-like protein 21A", "protein_names_refseq": "family with sequence similarity 119, member A; methyltransferase like 21A; methyltransferase-like protein 21A; protein N-lysine methyltransferase METTL21A; protein-lysine methyltransferase METTL21A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67099); (R-MMU-8876725)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;22872234", "class_list": "", "function": "Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2Y7", "ec_number_list": "2.1.1.-;2.1.1.359;3.6.4.10;2.1.1.372", "go_molecular_function": "GO:0051117 ATPase binding;GO:0030544 Hsp70 protein binding;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006479 protein methylation;GO:1903333 negative regulation of protein folding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR78-1", "uniprot_id": "MSD3_MOUSE", "mass": 32324.0, "length": 275, "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 3", "gene_name": "Msantd3", "organism": "Mouse", "refseq_name": "myb/SANT-like DNA-binding domain-containing protein 3", "refseq_ac": "NP_001139396", "gene_names_uniprotkb": "Msantd3", "gene_names_refseq": "2410046L14Rik; 2810429P03Rik; 5730528L13Rik; Msantd3; Mysantd3", "protein_names_uniprotkb": "Myb/SANT-like DNA-binding domain-containing protein 3", "protein_names_refseq": "UPF0439 protein C9orf30 homolog; myb/SANT-like DNA-binding domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66665)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYY5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CR78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWP6-1", "uniprot_id": "MSPD2_MOUSE", "mass": 59855.0, "length": 518, "protein_name": "Motile sperm domain-containing protein 2", "gene_name": "Mospd2", "organism": "Mouse", "refseq_name": "motile sperm domain-containing protein 2 isoform 2", "refseq_ac": "NP_001277452", "gene_names_uniprotkb": "Mospd2", "gene_names_refseq": "2410013I23Rik; Mospd2", "protein_names_uniprotkb": "Motile sperm domain-containing protein 2", "protein_names_refseq": "motile sperm domain-containing protein 2 isoform 2; motile sperm domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76763); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;30084848;31219806;32353176;34428180", "class_list": "", "function": "Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MOSPD2 is a therapeutic target for the treatment of CNS inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYF8;Q8BZB6;Q8C0G1;Q8R0T7", "ec_number_list": "", "go_molecular_function": "GO:0033149 FFAT motif binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006935 chemotaxis;GO:0051260 protein homooligomerization;GO:0090026 positive regulation of monocyte chemotaxis;GO:0140042 lipid droplet formation;GO:0090023 positive regulation of neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXI3-1", "uniprot_id": "MOXD1_MOUSE", "mass": 69678.0, "length": 613, "protein_name": "DBH-like monooxygenase protein 1", "gene_name": "Moxd1", "organism": "Mouse", "refseq_name": "DBH-like monooxygenase protein 1 precursor", "refseq_ac": "NP_067484", "gene_names_uniprotkb": "Moxd1; Dbhr; Mox", "gene_names_refseq": "3230402N08Rik; MNCb-5203; Moxd1", "protein_names_uniprotkb": "DBH-like monooxygenase protein 1; 1.14.17.-; DBH-related protein; Monooxygenase X", "protein_names_refseq": "DBH-like monooxygenase protein 1 precursor; DBH-like monooxygenase protein 1; DBH-related protein; monooxygenase X", "tax_id": 10090, "disease": "", "pathway": " (mmu:59012)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11397006;15337741;30084848;34428180", "class_list": "", "function": "Based on its sequence and localization, MOX (monooxygenase X) is predicted to hydroxylate a hydrophobic substrate in the endoplasmic reticulum., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFA8;Q8BUZ7;Q8R394;Q9JJA6", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005789 endoplasmic reticulum membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0042420 dopamine catabolic process;GO:0006589 octopamine biosynthetic process;GO:0042421 norepinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CXI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZJ6-1", "uniprot_id": "MS18A_MOUSE", "mass": 22949.0, "length": 204, "protein_name": "Protein Mis18-alpha", "gene_name": "Mis18a", "organism": "Mouse", "refseq_name": "protein Mis18-alpha", "refseq_ac": "NP_079918", "gene_names_uniprotkb": "Mis18a", "gene_names_refseq": "2610039C10Rik; 2810018N07Rik; Mis18a", "protein_names_uniprotkb": "Protein Mis18-alpha", "protein_names_refseq": "MIS18 kinetochore protein homolog A; protein Mis18-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:66578); (R-MMU-606279)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22516971;27670610", "class_list": "", "function": "Mis18alpha interacts with DNMT3A/3B, and this interaction is critical for maintaining DNA methylation and hence regulating epigenetic states of centromeric chromatin., [RefSeq, PubMed]; Mis18alpha is important for epidermal cell proliferation and stratification, because it is required for the deposition of CENP-A at the centromeric nucleosomes., [RefSeq, PubMed]; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0034080 CENP-A containing chromatin assembly;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D159-1", "uniprot_id": "MRAP_MOUSE", "mass": 14170.0, "length": 127, "protein_name": "Melanocortin-2 receptor accessory protein", "gene_name": "Mrap", "organism": "Mouse", "refseq_name": "melanocortin-2 receptor accessory protein", "refseq_ac": "NP_084120", "gene_names_uniprotkb": "Mrap; Falp", "gene_names_refseq": "1110025G12Rik; C21ORF61; Falp; Mrap; ORF61", "protein_names_uniprotkb": "Melanocortin-2 receptor accessory protein; Fat cell-specific low molecular weight protein; Fat tissue-specific low MW protein", "protein_names_refseq": "fat cell-specific low molecular weight protein; fat tissue-specific low MW protein; melanocortin-2 receptor accessory protein", "tax_id": 10090, "disease": "familial glucocorticoid deficiency (Disease Ontology:DOID:0080620); adrenal gland disease (Disease Ontology:DOID:9553)", "pathway": " (mmu:77037)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12054497;18162519;18981183;21183079;21750661;29217655;35053382", "class_list": "", "function": "Data (including data from studies in transgenic mice) suggest that Mrap plays critical role in (1) regulation of lipolysis in adipose tissue, (2) regulation of enzyme expression in adipose tissue, and (3) whole-body energy balance., [RefSeq, PubMed]; Falp protein strictly localizes at a compact perinuclear membrane compartment (Falp protein), [RefSeq, PubMed]; MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal., [RefSeq, PubMed]; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity)., [UniProtKB]; Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ49;Q8R439", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding;GO:0031780 corticotropin hormone receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050873 brown fat cell differentiation;GO:0072659 protein localization to plasma membrane;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAT2-1", "uniprot_id": "MRGBP_MOUSE", "mass": 22436.0, "length": 204, "protein_name": "MRG/MORF4L-binding protein", "gene_name": "Mrgbp", "organism": "Mouse", "refseq_name": "MRG/MORF4L-binding protein isoform 1", "refseq_ac": "NP_082755", "gene_names_uniprotkb": "Mrgbp", "gene_names_refseq": "1600027N09Rik; Mrgbp", "protein_names_uniprotkb": "MRG/MORF4L-binding protein; MRG-binding protein", "protein_names_refseq": "MRG-binding protein; MRG/MORF4L-binding protein isoform 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:73247)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AR7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERH6-1", "uniprot_id": "MOAP1_MOUSE", "mass": 39404.0, "length": 352, "protein_name": "Modulator of apoptosis 1", "gene_name": "Moap1", "organism": "Mouse", "refseq_name": "modulator of apoptosis 1", "refseq_ac": "NP_001136409", "gene_names_uniprotkb": "Moap1", "gene_names_refseq": "Map-1; MmMOAP1; Moap1; Pnma4", "protein_names_uniprotkb": "Modulator of apoptosis 1; MAP-1; MmMOAP1", "protein_names_refseq": "modulator of apoptosis 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64113)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11060313;16199525;17404571;19366867;27320914;30003515;33393215;33783314;34413232;34428180", "class_list": "", "function": "MAP-1 is a direct mitochondrial target of Bax., [RefSeq, PubMed]; MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling., [RefSeq, PubMed]; Retrotransposon-derived protein that forms virion-like capsids (PubMed:34413232). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (By similarity). Required for death receptor-dependent apoptosis (By similarity). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; These data suggest that MOAP-1 is required in the regulation of stress response in the dorsal raphe nucleus. Crosstalk between BDNF and 5-HT appears to play an important role in this stress response., [RefSeq, PubMed]; These findings reveal a role for MOAP-1 in Fas signaling in the liver by promoting MTCH2-mediated tBid recruitment to mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0006914 autophagy;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ERH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK54-1", "uniprot_id": "MSGN1_MOUSE", "mass": 20553.0, "length": 188, "protein_name": "Mesogenin-1", "gene_name": "Msgn1", "organism": "Mouse", "refseq_name": "mesogenin-1", "refseq_ac": "NP_062417", "gene_names_uniprotkb": "Msgn1", "gene_names_refseq": "Msgn1; Msgn; pMsgn1", "protein_names_uniprotkb": "Mesogenin-1; Paraxial mesoderm-specific mesogenin1; pMesogenin1; pMsgn1", "protein_names_refseq": "mesogenin-1; pMesogenin1; paraxial mesoderm-specific expression and regulatory capacities; paraxial mesoderm-specific mesogenin1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56184)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10837126;11124811", "class_list": "", "function": "Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0001756 somitogenesis;GO:0001707 mesoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JK54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0S2-1", "uniprot_id": "MMP24_MOUSE", "mass": 70460.0, "length": 618, "protein_name": "Matrix metalloproteinase-24", "gene_name": "Mmp24", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-24 preproprotein", "refseq_ac": "NP_034938", "gene_names_uniprotkb": "Mmp24; Mmp21; Mt5mmp", "gene_names_refseq": "MMP-21; MT5-MMP; MT5MMP; MTMMP5; Mmp24", "protein_names_uniprotkb": "Matrix metalloproteinase-24; 3.4.24.-; MMP-21; MMP-24; MT-MMP 5; MT5-MMP; MT5MMP; MTMMP5; Matrix metalloproteinase-21; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase", "protein_names_refseq": "matrix metalloproteinase-21; matrix metalloproteinase-24 preproprotein; matrix metalloproteinase-24; membrane type 5-MMP; membrane-type matrix metalloproteinase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:17391); (R-MMU-1592389)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10085137;10622708;11470782;11714638;14990567;19805319;24952463;26322584;37828378", "class_list": "", "function": "APP carboxy-terminal fragment generation is mediated in part by membrane-bound matrix metalloproteinases such as MT5-MMP, referred to as eta-secretase activity, [RefSeq, PubMed]; Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence (PubMed:19805319, PubMed:24952463). Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia (PubMed:19805319). Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence (PubMed:24952463). May play a role in axonal growth (PubMed:11714638). Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (PubMed:10622708)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein do not develop neuropathic pain with mechanical allodynia after sciatic nerve injury, display enhanced sensitivity to noxious thermal stimuli under basal conditions, and develop hyperalgesia during inflammation. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUV7;Q9Z0J9", "ec_number_list": "3.4.24.-;3.4.21.75;3.4.24.80", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0098609 cell-cell adhesion;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R0S2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGA4-1", "uniprot_id": "MTURN_MOUSE", "mass": 14841.0, "length": 131, "protein_name": "Maturin", "gene_name": "Mturn", "organism": "Mouse", "refseq_name": "maturin isoform a", "refseq_ac": "NP_001276669", "gene_names_uniprotkb": "Mturn", "gene_names_refseq": "2410066E13Rik; B230212L03Rik; Mturn", "protein_names_uniprotkb": "Maturin; Maturin neural progenitor differentiation regulator protein homolog", "protein_names_refseq": "UPF0452 protein C7orf41 homolog; maturin isoform a; maturin neural progenitor differentiation regulator protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68235)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;24095902;24681962;31957809;33506033", "class_list": "", "function": "C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; C7ORF41 overexpression significantly ameliorated hepatic inflammation and lipid accumulation in palmitic acid (PA)-treated hepatocytes, whereas C7ORF41 knockdown showed the opposite effects., [RefSeq, PubMed]; Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0045654 positive regulation of megakaryocyte differentiation;GO:0048666 neuron development;GO:0023051 regulation of signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CGA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88940-1", "uniprot_id": "MUSC_MOUSE", "mass": 21538.0, "length": 201, "protein_name": "Musculin", "gene_name": "Msc", "organism": "Mouse", "refseq_name": "musculin isoform 1", "refseq_ac": "NP_034957", "gene_names_uniprotkb": "Msc; Myor", "gene_names_refseq": "Msc; MyoR; bHLHa22", "protein_names_uniprotkb": "Musculin; Myogenic repressor", "protein_names_refseq": "musculin isoform 1; myogenic repressor", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:17681)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12493912;21750661;32239394;36848960;9767165;9892671", "class_list": "", "function": "Findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles, [RefSeq, PubMed]; Musculin Deficiency Aggravates Colonic Injury and Inflammation in Mice with Inflammatory Bowel Disease., [RefSeq, PubMed]; Musculin does not modulate the disease course of Experimental Autoimmune Encephalomyelitis and DSS colitis., [RefSeq, PubMed]; Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAZ1", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:1990830 cellular response to leukemia inhibitory factor;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11672-1", "uniprot_id": "NGAL_MOUSE", "mass": 22875.0, "length": 200, "protein_name": "Neutrophil gelatinase-associated lipocalin", "gene_name": "Lcn2", "organism": "Mouse", "refseq_name": "neutrophil gelatinase-associated lipocalin precursor", "refseq_ac": "NP_032517", "gene_names_uniprotkb": "Lcn2", "gene_names_refseq": "24p3; Lcn2; NRL; Sip24", "protein_names_uniprotkb": "Neutrophil gelatinase-associated lipocalin; 24p3; Lipocalin-2; NGAL; Oncogene 24p3; SV-40-induced 24p3 protein; Siderocalin LCN2; p25", "protein_names_refseq": "SV-40-induced 24P3 protein; neu-related lipocalin; neutrophil gelatinase-associated lipocalin precursor; neutrophil gelatinase-associated lipocalin; oncogene 24p3; p25; secreted inducible protein 24; siderocalin LCN2", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); COVID-19 (Disease Ontology:DOID:0080600); urinary tract infection (Disease Ontology:DOID:0080784); traumatic brain injury (Disease Ontology:DOID:0081292); pre-eclampsia (Disease Ontology:DOID:10591); essential hypertension (Disease Ontology:DOID:10825); hydronephrosis (Disease Ontology:DOID:11111); uveitis (Disease Ontology:DOID:13141); acute cystitis (Disease Ontology:DOID:13148); renovascular hypertension (Disease Ontology:DOID:1591); hyperuricemia (Disease Ontology:DOID:1920); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); hidradenitis suppurativa (Disease Ontology:DOID:2280); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); kidney disease (Disease Ontology:DOID:557); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); retinal degeneration (Disease Ontology:DOID:8466); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16819); (R-MMU-6798695); (R-MMU-6799990); (R-MMU-917937)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "12453413;15531878;16377569;16446425;1723819;1834059;20550936;21750661;21911364;2542864;25890235;30418175;8666241;8687399", "class_list": "", "function": "Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425). Can also bind siderophores from M.tuberculosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 27, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE34", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:1903981 enterobactin binding;GO:0140315 iron ion sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0060205 cytoplasmic vesicle lumen", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:1904646 cellular response to amyloid-beta;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P11672-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BNY6-1", "uniprot_id": "NCS1_MOUSE", "mass": 21879.0, "length": 190, "protein_name": "Neuronal calcium sensor 1", "gene_name": "Ncs1", "organism": "Mouse", "refseq_name": "neuronal calcium sensor 1", "refseq_ac": "NP_062655", "gene_names_uniprotkb": "Ncs1; Freq", "gene_names_refseq": "9430075O15Rik; A730032G13Rik; Freq; Mfreq; NCS-1; Ncs1", "protein_names_uniprotkb": "Neuronal calcium sensor 1; Frequenin homolog; NCS-1", "protein_names_refseq": "frequenin homolog; neuronal calcium sensor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14299)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11994284;12011096;21750661;25428506;30084848;32165725;34499766", "class_list": "", "function": "Contribution of neuronal calcium sensor 1 (Ncs-1) to anxiolytic-like and social behavior mediated by valproate and Gsk3 inhibition. Publication Status: Online-Only, [RefSeq, PubMed]; NCS-1 is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium., [RefSeq, PubMed]; Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development., [RefSeq, PubMed]; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity)., [UniProtKB]; PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJ84", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0019901 protein kinase binding;GO:0005509 calcium ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0050850 positive regulation of calcium-mediated signaling;GO:0009966 regulation of signal transduction;GO:0010975 regulation of neuron projection development;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BNY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35682-1", "uniprot_id": "MYADM_MOUSE", "mass": 35285.0, "length": 320, "protein_name": "Myeloid-associated differentiation marker", "gene_name": "Myadm", "organism": "Mouse", "refseq_name": "myeloid-associated differentiation marker", "refseq_ac": "NP_001087233", "gene_names_uniprotkb": "Myadm; Mug", "gene_names_refseq": "D7Wsu62e; Myadm", "protein_names_uniprotkb": "Myeloid-associated differentiation marker; Myeloid up-regulated protein", "protein_names_refseq": "myeloid up-regulated protein; myeloid-associated differentiation marker", "tax_id": 10090, "disease": "", "pathway": " (mmu:50918)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10733104;18250455;21750661;31599954;34862427;34887587;37828378;38832511", "class_list": "", "function": "Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Publication Status: Online-Only, [RefSeq, PubMed]; Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGS9;Q8BPS8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0045121 membrane raft;GO:0001726 ruffle;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0031579 membrane raft organization;GO:0044860 protein localization to plasma membrane raft;GO:0061028 establishment of endothelial barrier;GO:0010629 negative regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35682-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1A3-1", "uniprot_id": "MTRR_MOUSE", "mass": 77518.0, "length": 696, "protein_name": "Methionine synthase reductase", "gene_name": "Mtrr", "organism": "Mouse", "refseq_name": "methionine synthase reductase", "refseq_ac": "NP_001295404", "gene_names_uniprotkb": "Mtrr", "gene_names_refseq": "4732420G08; MSR; Mtrr", "protein_names_uniprotkb": "Methionine synthase reductase; 1.16.1.8; AqCbl reductase; Aquacobalamin reductase; MSR", "protein_names_refseq": "aqCbl reductase; aquacobalamin reductase; methionine synthase reductase", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); myelodysplastic syndrome (Disease Ontology:DOID:0050908); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); anencephaly (Disease Ontology:DOID:0060668); spina bifida (Disease Ontology:DOID:0080016); homocystinuria-megaloblastic anemia cblE type (Disease Ontology:DOID:0112255); heart disease (Disease Ontology:DOID:114); Parkinson's disease (Disease Ontology:DOID:14330); heart septal defect (Disease Ontology:DOID:1681); pancreatic cancer (Disease Ontology:DOID:1793); meningioma (Disease Ontology:DOID:3565); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); ulcerative colitis (Disease Ontology:DOID:8577); acute myeloid leukemia (Disease Ontology:DOID:9119); homocystinuria (Disease Ontology:DOID:9263); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:210009); (R-MMU-156581); (R-MMU-1614635); (R-MMU-9759218)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "18413293;21183079;21750661;24074862", "class_list": "", "function": "Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (PubMed:24074862). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity)., [UniProtKB, UniProtKB, PubMed]; Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Mutations in a similar gene in human have been associated with cblE complementation type homocystinuria-megaloblastic anemia and susceptibility to folate-sensitive neural tube defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]; Mtrr deficiency adversely impacts reproductive outcomes and cardiac development in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2C6;Q8R0Y3", "ec_number_list": "2.1.1.13;1.16.1.8;1.16.1.6;2.5.1.151", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0070402 NADPH binding;GO:0010181 FMN binding;GO:0003958 NADPH-hemoprotein reductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0050821 protein stabilization;GO:0009235 cobalamin metabolic process;GO:0046655 folic acid metabolic process;GO:0043418 homocysteine catabolic process;GO:0009086 methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C1A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02496-1", "uniprot_id": "MUC1_MOUSE", "mass": 64539.0, "length": 630, "protein_name": "Mucin-1", "gene_name": "Muc1", "organism": "Mouse", "refseq_name": "mucin-1 precursor", "refseq_ac": "NP_038633", "gene_names_uniprotkb": "Muc1; Muc-1", "gene_names_refseq": "CD227; EMA; Muc-1; Muc1", "protein_names_uniprotkb": "Mucin-1; Episialin; MUC-1; MUC1-CT", "protein_names_refseq": "episialin; mucin-1 precursor; mucin-1", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); biliary tract benign neoplasm (Disease Ontology:DOID:0050625); obstructive sleep apnea (Disease Ontology:DOID:0050848); autosomal dominant tubulointerstitial kidney disease 2 (Disease Ontology:DOID:0061118); dry eye syndrome (Disease Ontology:DOID:10140); prostate cancer (Disease Ontology:DOID:10283); otitis media (Disease Ontology:DOID:10754); urinary bladder cancer (Disease Ontology:DOID:11054); allergic conjunctivitis (Disease Ontology:DOID:11204); pneumocystosis (Disease Ontology:DOID:11339); adult respiratory distress syndrome (Disease Ontology:DOID:11394); heart disease (Disease Ontology:DOID:114); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary sarcoidosis (Disease Ontology:DOID:13406); bird fancier's lung (Disease Ontology:DOID:13891); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); mucinous adenocarcinoma (Disease Ontology:DOID:3030); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast adenocarcinoma (Disease Ontology:DOID:3458); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung adenocarcinoma (Disease Ontology:DOID:3910); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); measles (Disease Ontology:DOID:8622)", "pathway": " (mmu:17829); (R-MMU-913709); (R-MMU-977068)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1714452;17641781;1958179;20485683;21750661", "class_list": "", "function": "The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack., [UniProtKB]; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, Src and NF-kappaB pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity., [UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 8, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003712 transcription coregulator activity;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033629 negative regulation of cell adhesion mediated by integrin;GO:0010944 negative regulation of transcription by competitive promoter binding;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q02496-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UGX3-1", "uniprot_id": "NAT8L_MOUSE", "mass": 32777.0, "length": 299, "protein_name": "N-acetylaspartate synthetase", "gene_name": "Nat8l", "organism": "Mouse", "refseq_name": "N-acetylaspartate synthetase", "refseq_ac": "NP_001001985", "gene_names_uniprotkb": "Nat8l", "gene_names_refseq": "1110038O08Rik; Nat8l; Shati", "protein_names_uniprotkb": "N-acetylaspartate synthetase; 2.3.1.17; N-acetyltransferase 8-like protein; NAA synthetase; Protein Shati", "protein_names_refseq": "N-acetylaspartate synthetase; N-acetyltransferase 8-like protein; NAA synthase; NAA synthetase; aspartate N-acetyltransferase; protein Shati", "tax_id": 10090, "disease": "", "pathway": " (mmu:269642); (R-MMU-8963693)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17626222;19014384;19807691;20385109;20643647;21750661;30084848;34428180;35428956;36580805", "class_list": "", "function": "Asp-NAT enzyme activity in Nat8l-transfected cells is more than 300 times that of the mock-transfected controls and shows an extraordinarily high enzymatic specificity for aspartate, with less than 1% of enzymatic activity using glutamate as substrate. GeneRIF: Nat8l is highly specific to aspartate. It is localized in mitochondria and microsomes, with a pattern comparable to the localization of NAA in brain. It is similar to NAG synthetase in catalytic mechanism without the involvement of cysteine., [RefSeq, PubMed]; Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA (PubMed:19807691, PubMed:20385109, PubMed:20643647). Promotes dopamine uptake by regulating TNF expression (PubMed:19014384). Attenuates methamphetamine-induced inhibition of dopamine uptake (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA. Promotes dopamine uptake by regulating TNF expression. Attenuates methamphetamine-induced inhibition of dopamine uptake., [UniProtKB, UniProtKB]; Hindering NAT8L expression in hepatocellular carcinoma increases cytosolic aspartate delivery that fosters pentose phosphate pathway and purine biosynthesis promoting cell proliferation., [RefSeq, PubMed]; N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice., [RefSeq, PubMed]; Results indicated that NAT8L, but not NAT14, catalysed the synthesis of NAA from L-aspartate and acetyl-CoA. Publication Status: Online-Only, [RefSeq, PubMed]; Roles of shati in methamphetamine (METH)-regulated behavioral alternations are likely to be mediated by its inhibitory effects on METH-induced increase of dopamine(DA) overflow in nucleus accumbens and METH-induced decrease in DA uptake in midbrain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH43;Q6DID6;Q8K065", "ec_number_list": "2.3.1.17", "go_molecular_function": "GO:0017188 L-aspartate N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission;GO:0006083 acetate metabolic process;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UGX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPM9-1", "uniprot_id": "MTMRA_MOUSE", "mass": 88197.0, "length": 771, "protein_name": "Myotubularin-related protein 10", "gene_name": "Mtmr10", "organism": "Mouse", "refseq_name": "myotubularin-related protein 10 isoform 1", "refseq_ac": "NP_766330", "gene_names_uniprotkb": "Mtmr10", "gene_names_refseq": "Mtmr10", "protein_names_uniprotkb": "Myotubularin-related protein 10; Inactive phosphatidylinositol 3-phosphatase 10", "protein_names_refseq": "inactive phosphatidylinositol 3-phosphatase 10; myotubularin-related protein 10 isoform 1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:233315)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;14691545;21750661;25605945;30084848;31599954;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9876, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE99", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TPM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVG8-1", "uniprot_id": "NAT14_MOUSE", "mass": 21778.0, "length": 206, "protein_name": "Probable N-acetyltransferase 14", "gene_name": "Nat14", "organism": "Mouse", "refseq_name": "probable N-acetyltransferase 14", "refseq_ac": "NP_958743", "gene_names_uniprotkb": "Nat14", "gene_names_refseq": "Nat14", "protein_names_uniprotkb": "Probable N-acetyltransferase 14; 2.3.1.-", "protein_names_refseq": "probable N-acetyltransferase 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:269854)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19807691;21750661", "class_list": "", "function": "May act as a transcription factor regulating the expression of coproporphyrinogen oxidase by binding to a promoter regulatory element., [UniProtKB, UniProtKB]; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro (By similarity)., [UniProtKB]; Probable acetyltransferase., [UniProtKB, UniProtKB, UniProtKB]; Results indicated that NAT8L, but not NAT14, catalysed the synthesis of NAA from L-aspartate and acetyl-CoA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BVG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6J9-1", "uniprot_id": "NAL4B_MOUSE", "mass": 99955.0, "length": 863, "protein_name": "NACHT, LRR and PYD domains-containing protein 4B", "gene_name": "Nlrp4b", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 4B", "refseq_ac": "NP_766069", "gene_names_uniprotkb": "Nlrp4b; Nalp4b", "gene_names_refseq": "E330024M09; Nalp-gamma; Nalp4b; Nlrp4b", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 4B; NALP-gamma", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 4B; NACHT, leucine rich repeat and PYD containing 4B; NACHT/LRR/pyrin domain-containing protein 4b", "tax_id": 10090, "disease": "", "pathway": " (mmu:210045)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15317747;21750661", "class_list": "", "function": "May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66X16", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050727 regulation of inflammatory response;GO:0070936 protein K48-linked ubiquitination;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C6J9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0S4-1", "uniprot_id": "NEUL2_MOUSE", "mass": 31537.0, "length": 285, "protein_name": "Neuralized-like protein 2", "gene_name": "Neurl2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Neurl2; Ozz", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuralized-like protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:415115); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14960280;21750661", "class_list": "", "function": "Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0030891 VCB complex;GO:0005927 muscle tendon junction", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination;GO:0045214 sarcomere organization;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0S4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48972-1", "uniprot_id": "MYBB_MOUSE", "mass": 79103.0, "length": 704, "protein_name": "Myb-related protein B", "gene_name": "Mybl2", "organism": "Mouse", "refseq_name": "myb-related protein B", "refseq_ac": "NP_032678", "gene_names_uniprotkb": "Mybl2; Bmyb", "gene_names_refseq": "B-Myb; Bmyb; Mybl2", "protein_names_uniprotkb": "Myb-related protein B; B-Myb; Myb-like protein 2", "protein_names_refseq": "myb-like protein 2; myb-related protein B; myeloblastosis oncogene-like 2", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:17865)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1501895;21750661;21952136;22872234;25428506;27090638;30084848;30779550;31219806;36854682;39254648;8334989", "class_list": "", "function": "A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2., [RefSeq, PubMed]; Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031523 Myb complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0090307 mitotic spindle assembly;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P48972-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AI05-1", "uniprot_id": "NDOR1_MOUSE", "mass": 67183.0, "length": 598, "protein_name": "NADPH-dependent diflavin oxidoreductase 1", "gene_name": "Ndor1", "organism": "Mouse", "refseq_name": "NADPH-dependent diflavin oxidoreductase 1 isoform 1", "refseq_ac": "NP_001075945", "gene_names_uniprotkb": "Ndor1", "gene_names_refseq": "4930447P04Rik; NR1; Ndor1; Ndor; Tg(UBC-cre/ERT2)1Ejb; Ubc-cre", "protein_names_uniprotkb": "NADPH-dependent diflavin oxidoreductase 1; 1.18.1.-; NADPH-dependent FMN and FAD-containing oxidoreductase", "protein_names_refseq": "NADPH-dependent FMN and FAD-containing oxidoreductase; NADPH-dependent diflavin oxidoreductase 1 isoform 1; Tg(UBC-cre)1Ejb; Tg(UBC-cre/ESR1)1Ejb", "tax_id": 10090, "disease": "", "pathway": " (mmu:78797)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (By similarity). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (By similarity)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQZ6;Q80WC5", "ec_number_list": "1.18.1.-", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AI05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AQP0-1", "uniprot_id": "MYH7B_MOUSE", "mass": 221497.0, "length": 1941, "protein_name": "Myosin-7B", "gene_name": "Myh7b", "organism": "Mouse", "refseq_name": "myosin-7B", "refseq_ac": "NP_001078847", "gene_names_uniprotkb": "Myh7b", "gene_names_refseq": "Myh14; Myh7b", "protein_names_uniprotkb": "Myosin-7B; Myosin cardiac muscle beta chain; Myosin heavy chain 7B, cardiac muscle beta isoform", "protein_names_refseq": "myosin-7B", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:668940)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19948655;22638570;34418053;37507081", "class_list": "", "function": "Involved in muscle contraction., [UniProtKB]; Myh7b, the ortholog of slow myosin 2 (SM2) of frogs and birds, is detected as mRNA in heart, slow muscles and extraocular muscles. MYH7b protein is detected only in a minor fiber population in extraocular muscles, corresponding to slow-tonic fibers., [RefSeq, PubMed]; MyoD and Eos form an active transcriptional complex on the chromatin to regulate the expression of the endogenous Myh7b/miR-499 gene in muscle cells., [RefSeq, PubMed]; This gene encodes a myosin heavy chain. The encoded protein forms a hexamer comprised of two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0032982 myosin filament;GO:0097512 cardiac myofibril;GO:0016460 myosin II complex", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0086004 regulation of cardiac muscle cell contraction;GO:0050848 regulation of calcium-mediated signaling;GO:1905289 regulation of CAMKK-AMPK signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AQP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09118-1", "uniprot_id": "NET1_MOUSE", "mass": 67810.0, "length": 604, "protein_name": "Netrin-1", "gene_name": "Ntn1", "organism": "Mouse", "refseq_name": "netrin-1 precursor", "refseq_ac": "NP_032770", "gene_names_uniprotkb": "Ntn1", "gene_names_refseq": "Netrin-1; Ntn1", "protein_names_uniprotkb": "Netrin-1", "protein_names_refseq": "netrin-1 precursor", "tax_id": 10090, "disease": "mirror movements 4 (Disease Ontology:DOID:0070638)", "pathway": " (mmu:18208)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10381568;18585357;21750661;27068745;28483977;30899004;35820727;7604039;8978605", "class_list": "", "function": "Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1ARR0;Q60832;Q9QY50", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0007409 axonogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0016358 dendrite development;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O09118-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY36-1", "uniprot_id": "NAA10_MOUSE", "mass": 26520.0, "length": 235, "protein_name": "N-alpha-acetyltransferase 10", "gene_name": "Naa10", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 10 isoform 1", "refseq_ac": "NP_063923", "gene_names_uniprotkb": "Naa10; Ard1a; Ard1; Te2", "gene_names_refseq": "2310039H09Rik; Ard1a; Ard1; Naa10; Te2", "protein_names_uniprotkb": "N-alpha-acetyltransferase 10; 2.3.1.255; N-terminal acetyltransferase complex ARD1 subunit homolog A; NatA catalytic subunit Naa10", "protein_names_refseq": "ARD1 homolog A, N-acetyltransferase; N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10; N-alpha-acetyltransferase 10 isoform 1; N-terminal acetyltransferase complex ARD1 subunit homolog A; Nalpha acetyltransferase 10; alpha-N-acetyltransferase 1A; natA catalytic subunit Naa10", "tax_id": 10090, "disease": "Ogden syndrome (Disease Ontology:DOID:0050781); syndromic microphthalmia 1 (Disease Ontology:DOID:0111799)", "pathway": " (mmu:56292)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12464182;12888564;16376303;17161380;21750661;30993557;31422874;32542692;34355692;34428180;38713657", "class_list": "", "function": "Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase., [RefSeq, PubMed]; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:12888564). Acetylates amino termini that are devoid of initiator methionine (By similarity). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development (By similarity). Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (By similarity). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (By similarity). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (By similarity). Acetylates HIST1H4A (By similarity). Acts as a negative regulator of sister chromatid cohesion during mitosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; Mouse ortholog (225) of ARD1 strongly decreased the level of hypoxia inducible factor (HIF)-1 alpha and increased the extent of acetylation, whereas mARD1(235) variants had a much weaker effect on HIF-1 alpha stability and acetylation., [RefSeq, PubMed]; Naa10p-mediated N-terminal acetylation of Pgc1alpha downregulates thermogenic gene expression in beige adipocytes., [RefSeq, PubMed]; Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that ARD1(235) and ARD1(225) isoforms may have different activities and function in different subcellular compartments of mammalian cells., [RefSeq, PubMed]; We established Naa10 knockout mESCs to test this hypothesis. We found that Naa10 deficiency attenuated differentiation towards the epiblast lineage, deviating towards primitive endoderm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.255", "go_molecular_function": "GO:0043022 ribosome binding;GO:0008080 N-acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1990189 protein N-terminal-serine acetyltransferase activity;GO:1990190 protein-N-terminal-glutamate acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031415 NatA complex", "go_biological_process": "GO:0051604 protein maturation;GO:2000719 negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric;GO:1904592 positive regulation of protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QY36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z83-1", "uniprot_id": "MYH7_MOUSE", "mass": 222879.0, "length": 1935, "protein_name": "Myosin-7", "gene_name": "Myh7", "organism": "Mouse", "refseq_name": "myosin-7", "refseq_ac": "NP_542766", "gene_names_uniprotkb": "Myh7", "gene_names_refseq": "B-MHC; MYH-beta/slow; MyHC-I; Myh7; Myhc-b; Myhcb; beta-MHC; betaMHC; myHC-beta; myHC-slow", "protein_names_uniprotkb": "Myosin-7; MyHC-beta; MyHC-slow; Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform", "protein_names_refseq": "myosin heavy chain 7; myosin heavy chain, cardiac muscle, fetal; myosin-7", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); distal myopathy 1 (Disease Ontology:DOID:0070197); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal recessive hyaline body myopathy (Disease Ontology:DOID:0111268); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); distal myopathy (Disease Ontology:DOID:11720); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); congenital heart disease (Disease Ontology:DOID:1682); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:140781)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12626511;21750661;36288343;37507081;39927985", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGM2;Q3TZN2", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0030017 sarcomere;GO:0032982 myosin filament", "go_biological_process": "GO:0031449 regulation of slow-twitch skeletal muscle fiber contraction;GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91Z83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCM8-1", "uniprot_id": "NCLN_MOUSE", "mass": 62908.0, "length": 563, "protein_name": "BOS complex subunit NCLN", "gene_name": "Ncln", "organism": "Mouse", "refseq_name": "BOS complex subunit NCLN precursor", "refseq_ac": "NP_598770", "gene_names_uniprotkb": "Ncln", "gene_names_refseq": "3100002P13Rik; Ncln", "protein_names_uniprotkb": "BOS complex subunit NCLN; Nicalin; Nicastrin-like protein", "protein_names_refseq": "BOS complex subunit NCLN precursor; BOS complex subunit NCLN; nicalin homolog; nicastrin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:103425)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30899004;34203471", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7Y4;Q9CX81", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0009966 regulation of signal transduction;GO:0043254 regulation of protein-containing complex assembly;GO:0061635 regulation of protein complex stability;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJ48-1", "uniprot_id": "NAGPA_MOUSE", "mass": 56044.0, "length": 517, "protein_name": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase", "gene_name": "Nagpa", "organism": "Mouse", "refseq_name": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor", "refseq_ac": "NP_038824", "gene_names_uniprotkb": "Nagpa", "gene_names_refseq": "Nagpa; UCE", "protein_names_uniprotkb": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; 3.1.4.45; Mannose 6-phosphate-uncovering enzyme; Phosphodiester alpha-GlcNAcase", "protein_names_refseq": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor; mannose 6-phosphate-uncovering enzyme; phosphodiester alpha-GlcNAcase", "tax_id": 10090, "disease": "", "pathway": " (mmu:27426)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10551838;19710420;21750661;25428506", "class_list": "glycogene", "function": "Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases., [UniProtKB]; UCE -/- mice were viable, grew normally & lacked detectable histologic abnormalities, but plasma levels of 6 acid hydrolases were elevated. UCE accounts for all the uncovering activity in the Golgi., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUT5;Q8CHQ8;Q9QZE6", "ec_number_list": "3.1.4.45", "go_molecular_function": "GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0033299 secretion of lysosomal enzymes", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BJ48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1L6-1", "uniprot_id": "MTMRB_MOUSE", "mass": 78396.0, "length": 700, "protein_name": "Myotubularin-related protein 11", "gene_name": "Mtmr11", "organism": "Mouse", "refseq_name": "myotubularin-related protein 11", "refseq_ac": "NP_852074", "gene_names_uniprotkb": "Mtmr11", "gene_names_refseq": "Cra; Mtmr11", "protein_names_uniprotkb": "Myotubularin-related protein 11; Inactive phosphatidylinositol 3-phosphatase 11", "protein_names_refseq": "cisplatin resistance associated; inactive phosphatidylinositol 3-phosphatase 11; myotubularin-related protein 11", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:194126)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UV0;Q8CG88", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3V1L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q5R7-1", "uniprot_id": "NAL12_MOUSE", "mass": 119319.0, "length": 1054, "protein_name": "NACHT, LRR and PYD domains-containing protein 12", "gene_name": "Nlrp12", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 12", "refseq_ac": "NP_001028603", "gene_names_uniprotkb": "Nlrp12; NALP12", "gene_names_refseq": "Nalp12; Nlrp12; PYPAF7; monarch-1", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 12; Monarch-1; PYPAF7; PYRIN-containing APAF1-like protein 7", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 12; PYRIN-containing APAF1-like protein 7", "tax_id": 10090, "disease": "familial cold autoinflammatory syndrome 2 (Disease Ontology:DOID:0090063)", "pathway": " (mmu:378425)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20861349;22094258;22291998;26521018;30212649;30559449", "class_list": "", "function": "NLRP12 does not play a vital role in regulating Th2 driven airway inflammation using common model systems that are physiologically relevant to human disease., [RefSeq, PubMed]; NLRP12 has a critical role in maintaining intestinal homeostasis and providing protection against colorectal tumorigenesis., [RefSeq, PubMed]; NLRP12 is important in maintaining neutrophils and peripheral DCs in a migration-competent state, [RefSeq, PubMed]; Plays an essential role as an potent mitigator of inflammation (PubMed:26521018, PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:30559449). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (By similarity). Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (PubMed:30212649)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEM3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9Q5R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQH3-1", "uniprot_id": "NDUB5_MOUSE", "mass": 21710.0, "length": 189, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "gene_name": "Ndufb5", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor", "refseq_ac": "NP_079592", "gene_names_uniprotkb": "Ndufb5", "gene_names_refseq": "0610007D05Rik; CI-SGDH; Ndufb5; SGDH", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; CI-SGDH; Complex I-SGDH; NADH-ubiquinone oxidoreductase SGDH subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; NADH-ubiquinone oxidoreductase SGDH subunit; complex I-SGDH", "tax_id": 10090, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:66046); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16075062;21750661;26495903;34428180;36288343;37453647;37507081;38575788;38982516", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZJ0-1", "uniprot_id": "MUS81_MOUSE", "mass": 61531.0, "length": 551, "protein_name": "Structure-specific endonuclease subunit MUS81", "gene_name": "Mus81", "organism": "Mouse", "refseq_name": "structure-specific endonuclease subunit MUS81", "refseq_ac": "NP_082153", "gene_names_uniprotkb": "Mus81", "gene_names_refseq": "1200008A18Rik; Mus81", "protein_names_uniprotkb": "Structure-specific endonuclease subunit MUS81; 3.1.22.-; Crossover junction endonuclease MUS81", "protein_names_refseq": "MUS81 endonuclease homolog; crossover junction endonuclease MUS81; structure-specific endonuclease subunit MUS81", "tax_id": 10090, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645); Marfan syndrome (Disease Ontology:DOID:14323); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:71711); (R-MMU-5693568); (R-MMU-6783310)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11741546;14609959;15205536;16107704;21750661;25428506;27010503;30084848;31219806;34428180;35820727;37953555;41018975", "class_list": "", "function": "A study of protective effects of Mus81 in preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability (PubMed:14609959, PubMed:15205536, PubMed:16107704). Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing (PubMed:14609959). Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance. MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mus81 acts at a late step in the repair of cross-link-induced lesions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R356", "ec_number_list": "5.6.2.1;2.3.2.27;5.6.2.4;3.6.-.-;3.6.4.-;5.6.2.3;3.1.-.-;2.7.11.1;3.1.21.-;3.1.4.1;3.6.4.13;3.4.19.12;3.5.2.6;2.3.1.48;2.3.1.-;3.1.22.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity;GO:0008821 crossover junction DNA endonuclease activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0001650 fibrillar center;GO:0005657 replication fork;GO:0048476 Holliday junction resolvase complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0033687 osteoblast proliferation;GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91ZJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SUV5-1", "uniprot_id": "MYLK4_MOUSE", "mass": 43905.0, "length": 386, "protein_name": "Myosin light chain kinase family member 4", "gene_name": "Mylk4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mylk4; Sgk085", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin light chain kinase family member 4; 2.7.11.1; SgK085; Sugen kinase 85", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0004687 myosin light chain kinase activity;GO:0106310 protein serine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SUV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47802-1", "uniprot_id": "MTX1_MOUSE", "mass": 35624.0, "length": 317, "protein_name": "Metaxin-1", "gene_name": "Mtx1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mtx1; Mtxn; Mtx", "gene_names_refseq": "", "protein_names_uniprotkb": "Metaxin-1; Mitochondrial outer membrane import complex protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-9013404)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10381257;21750661;22872234;30084848;31219806;34428180;37507081;7753840;8871542;9045676;9705320", "class_list": "", "function": "Involved in transport of proteins into the mitochondrion. Essential for embryonic development., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0015031 protein transport;GO:0070096 mitochondrial outer membrane translocase complex assembly;GO:0007005 mitochondrion organization;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47802-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7V9-1", "uniprot_id": "NAAA_MOUSE", "mass": 40075.0, "length": 362, "protein_name": "N-acylethanolamine-hydrolyzing acid amidase", "gene_name": "Naaa", "organism": "Mouse", "refseq_name": "N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor", "refseq_ac": "NP_001157159", "gene_names_uniprotkb": "Naaa; Asahl", "gene_names_refseq": "2210023K21Rik; 3830414F09Rik; Asahl; Naaa", "protein_names_uniprotkb": "N-acylethanolamine-hydrolyzing acid amidase; 3.5.1.23; 3.5.1.60; ASAH-like protein; Acylsphingosine deacylase NAAA; N-acylsphingosine amidohydrolase-like", "protein_names_refseq": "ASAH-like protein; N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor; N-acylethanolamine-hydrolyzing acid amidase; acylsphingosine deacylase NAAA", "tax_id": 10090, "disease": "", "pathway": " (mmu:67111); (R-MMU-112310)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15655246;16154384;21750661;23218523;25384424;26740625;30301806;34428180;38402219", "class_list": "glycogene", "function": "Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NAAA inhibition increases palmitoylethanolamide levels in the colon and reduces colon inflammation and systemic inflammation, [RefSeq, PubMed]; NAAA regulates peripheral pain initiation by interrupting endogenous fatty acid ethanolamide signaling at PPAR-alpha., [RefSeq, PubMed]; NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase cooperatively degrade anandamide and other N-acylethanolamines in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5KTC6;Q99KM3;Q9D6B4", "ec_number_list": "3.5.1.23;3.5.1.-;3.5.1.60", "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0047412 N-(long-chain-acyl)ethanolamine deacylase activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0070291 N-acylethanolamine metabolic process;GO:0006670 sphingosine metabolic process;GO:0006631 fatty acid metabolic process;GO:0016042 lipid catabolic process;GO:0070292 N-acylphosphatidylethanolamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D7V9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCB1-1", "uniprot_id": "NDC1_MOUSE", "mass": 75409.0, "length": 673, "protein_name": "Nucleoporin NDC1", "gene_name": "Ndc1", "organism": "Mouse", "refseq_name": "nucleoporin NDC1", "refseq_ac": "NP_082631", "gene_names_uniprotkb": "Ndc1; Tmem48", "gene_names_refseq": "2810475A17Rik; Ndc1; Tmem48; sks", "protein_names_uniprotkb": "Nucleoporin NDC1; Transmembrane protein 48", "protein_names_refseq": "nucleoporin NDC1; transmembrane protein 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:72787); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-9615933)", "pathway_count": 19, "publication_count": 10, "publication_id_list": "16702233;21183079;21750661;24045954;25428506;27854341;30084848;34428180;35820727;36852467", "class_list": "", "function": "A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice., [RefSeq, PubMed]; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In mice sperm with mutated SEPT12, NDC1 dispersed around the manchette region of the sperm head and annulus, compared with concentrating at the sperm neck of wild-type sperm. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0007283 spermatogenesis;GO:0015031 protein transport;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VCB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08762-1", "uniprot_id": "NETR_MOUSE", "mass": 84118.0, "length": 761, "protein_name": "Neurotrypsin", "gene_name": "Prss12", "organism": "Mouse", "refseq_name": "neurotrypsin precursor", "refseq_ac": "NP_032965", "gene_names_uniprotkb": "Prss12; Bssp3", "gene_names_refseq": "Bssp-3; Prss12; motopsin", "protein_names_uniprotkb": "Neurotrypsin; 3.4.21.-; BSSP-3; Brain-specific serine protease 3; Motopsin; Serine protease 12", "protein_names_refseq": "brain-specific serine protease 3; neurotrypsin precursor; neurotrypsin; protease, serine 12 neurotrypsin (motopsin); serine protease 12", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 1 (Disease Ontology:DOID:0081177); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:19142)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "38153682;9245503;9344839", "class_list": "", "function": "Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus., [RefSeq, PubMed]; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "GO:0006508 proteolysis;GO:0006887 exocytosis;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08762-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09105-1", "uniprot_id": "NDF4_MOUSE", "mass": 37133.0, "length": 330, "protein_name": "Neurogenic differentiation factor 4", "gene_name": "Neurod4", "organism": "Mouse", "refseq_name": "neurogenic differentiation factor 4", "refseq_ac": "NP_001316418", "gene_names_uniprotkb": "Neurod4; Ath3; Atoh3", "gene_names_refseq": "ATH-3; Atoh3; MATH-3; Math3; Neurod4; bHLHa4", "protein_names_uniprotkb": "Neurogenic differentiation factor 4; Helix-loop-helix protein mATH-3; NeuroD4; Protein atonal homolog 3; mATH3", "protein_names_refseq": "atonal homolog 3; helix-loop-helix protein mATH-3; neurogenic differentiation factor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:11923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11861467;9029157;9497361", "class_list": "", "function": "Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina., [UniProtKB, PubMed]; This gene belongs to the neurogenic differentiation factor family and encodes a basic helix-loop-helix (bHLH) transcription factor which is expressed in the developing nervous system with high levels of expression in the brain, retina and cranial ganglions. Expression gradually becomes restricted to the neural retina. It is a key gene in the Ngn2-regulated neuronal differentiation pathway, coordinating the onset of cortical gene transcription. This gene also regulates amacrine cell fate determination in the retina. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O09105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88495-1", "uniprot_id": "MTR1L_MOUSE", "mass": 65130.0, "length": 591, "protein_name": "Melatonin-related receptor", "gene_name": "Gpr50", "organism": "Mouse", "refseq_name": "melatonin-related receptor isoform 2", "refseq_ac": "NP_001295430", "gene_names_uniprotkb": "Gpr50", "gene_names_refseq": "Gpr50; H9", "protein_names_uniprotkb": "Melatonin-related receptor; G protein-coupled receptor 50; H9", "protein_names_refseq": "melatonin-related receptor isoform 2; melatonin-related receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14765)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17957037;19699797;20210849;21858214;25689717;29572483;30059200;30084848;36333974;9933574", "class_list": "", "function": "Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus., [RefSeq, PubMed]; G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:17957037, PubMed:19699797). Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (PubMed:25689717). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalization (PubMed:21858214). Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; GPR50 is a TbetaRI co-receptor with potential impact on cancer development Publication Status: Online-Only, [RefSeq, PubMed]; GPR50 is an important regulator of energy metabolism, [RefSeq, PubMed]; Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes., [RefSeq, PubMed]; This gene encodes a multipass membrane protein that is thought to act as a G protein-coupled receptor. Activity of this protein may be important in neurotransmitter and glucocorticoid signalling. Mutation of this gene causes a decreased ability to maintain a constant body temperature, resulting in torpor, as well as an increased metabolic rate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1S8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008502 melatonin receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88495-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05977-1", "uniprot_id": "MYL1_MOUSE", "mass": 20595.0, "length": 188, "protein_name": "Myosin light chain 1/3, skeletal muscle isoform", "gene_name": "Myl1", "organism": "Mouse", "refseq_name": "myosin light chain 1/3, skeletal muscle isoform isoform 3f", "refseq_ac": "NP_001106858", "gene_names_uniprotkb": "Myl1; Mylf", "gene_names_refseq": "MLC1f; MLC3f; Myl1; Mylf", "protein_names_uniprotkb": "Myosin light chain 1/3, skeletal muscle isoform; MLC1/MLC3; MLC1F/MLC3F; Myosin light chain A1/A2; Myosin light chain alkali 1/2", "protein_names_refseq": "A1 catalytic; A2 catalytic; MLC1/MLC3; MLC1F/MLC3F; atrial, embryonic; myosin light chain 1/3, skeletal muscle isoform isoform 3f; myosin light chain A1/A2; myosin light chain alkali 1/2; myosin light chain, alkali, fast skeletal muscle; myosin, light polypeptide 1, alkali; myosin, light polypeptide 4, alkali", "tax_id": 10090, "disease": "congenital myopathy 14 (Disease Ontology:DOID:0081346)", "pathway": " (mmu:17901); (R-MMU-390522)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;3194193;6091905", "class_list": "", "function": "Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05978", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0030016 myofibril;GO:0043292 contractile muscle fiber;GO:0016460 myosin II complex;GO:0016461 unconventional myosin complex;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P05977-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09541-1", "uniprot_id": "MYL4_MOUSE", "mass": 21159.0, "length": 193, "protein_name": "Myosin light chain 4", "gene_name": "Myl4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Myl4; Mlc1a; Myla", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin light chain 4; MLC1A; MLC1EMB; Myosin light chain 1, atrial/fetal isoform", "protein_names_refseq": "", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (R-MMU-390522)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;2842339;3194193;37507081;39927985;41018975", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0031672 A band;GO:0016460 myosin II complex;GO:0016461 unconventional myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P09541-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12979-1", "uniprot_id": "MYOG_MOUSE", "mass": 25203.0, "length": 224, "protein_name": "Myogenin", "gene_name": "Myog", "organism": "Mouse", "refseq_name": "myogenin", "refseq_ac": "NP_112466", "gene_names_uniprotkb": "Myog", "gene_names_refseq": "MYF4; Myog; bHLHc3; myo", "protein_names_uniprotkb": "Myogenin; MYOD1-related protein", "protein_names_refseq": "MYOD1-related protein; myogenin", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17928); (R-MMU-525793)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "12196028;1324403;14966278;15706034;16407395;16424906;16437161;1705035;21465538;2168405;21798092;22235349;22847234;23364797;2473006;2552320;7929574;8393145;8393146", "class_list": "", "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Also plays a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0014891 striated muscle atrophy;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P12979-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13541-1", "uniprot_id": "MYH3_MOUSE", "mass": 223791.0, "length": 1940, "protein_name": "Myosin-3", "gene_name": "Myh3", "organism": "Mouse", "refseq_name": "myosin-3", "refseq_ac": "NP_001093105", "gene_names_uniprotkb": "Myh3; Myhse", "gene_names_refseq": "MyHC-emb; Myh3; Myhs-e; Myhse", "protein_names_uniprotkb": "Myosin-3; Myosin heavy chain 3", "protein_names_refseq": "myosin heavy chain 3; myosin-3", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A (Disease Ontology:DOID:0081321); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B (Disease Ontology:DOID:0081322); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B (Disease Ontology:DOID:0111599); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:17883); (R-MMU-390522)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;25428506;34203471;36288343;3864153;39927985", "class_list": "", "function": "Muscle contraction., [UniProtKB]; Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V183;Q5SUD4", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0043292 contractile muscle fiber;GO:0016459 myosin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13541-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24526-1", "uniprot_id": "MYP2_MOUSE", "mass": 14935.0, "length": 132, "protein_name": "Myelin P2 protein", "gene_name": "Pmp2", "organism": "Mouse", "refseq_name": "myelin P2 protein", "refseq_ac": "NP_001025476", "gene_names_uniprotkb": "Pmp2", "gene_names_refseq": "P2; Pmp2", "protein_names_uniprotkb": "Myelin P2 protein", "protein_names_refseq": "myelin P2 protein", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 1G (Disease Ontology:DOID:0111560)", "pathway": " (mmu:18857)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1711100;24849898;28447247;38311982", "class_list": "", "function": "In a sciatic nerve crush model, temporal structural and functional changes were found in P2 knock-out animals as compared to wild-type., [RefSeq, PubMed]; May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity)., [UniProtKB]; PMP2 regulates myelin thickening and ATP production during remyelination., [RefSeq, PubMed]; Study results, together with observations that Pmp2 binds and transports fatty acids to membranes, uncover a role for Pmp2 in lipid homeostasis of myelinating Schwann cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KL10", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0061024 membrane organization;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P24526-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46735-1", "uniprot_id": "MYO1B_MOUSE", "mass": 128564.0, "length": 1107, "protein_name": "Unconventional myosin-Ib", "gene_name": "Myo1b", "organism": "Mouse", "refseq_name": "unconventional myosin-Ib isoform 2", "refseq_ac": "NP_034993", "gene_names_uniprotkb": "Myo1b", "gene_names_refseq": "MIH-L; MMIa; Myo1b", "protein_names_uniprotkb": "Unconventional myosin-Ib; MIH-L; MMI-alpha; MMIa; Myosin I alpha", "protein_names_refseq": "MMI-alpha; Myosin IA (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L); molecular motor; myosin I alpha; myosin-Ib; unconventional myosin-Ib isoform 2; unconventional myosin-Ib", "tax_id": 10090, "disease": "", "pathway": " (mmu:17912)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;29588377;33300544;34428180;34887587;36064721;36654782;37453647;39927985;8449986;8458427", "class_list": "", "function": "A myosin 1 plays a major role in neuronal symmetry breaking and argue for a mechanical control of the actin cytoskeleton both in actin waves and in the growth cones by this myosin., [RefSeq, PubMed]; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70244;Q80VD8", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0051017 actin filament bundle assembly;GO:0030048 actin filament-based movement;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P46735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48986-1", "uniprot_id": "NDF6_MOUSE", "mass": 38644.0, "length": 337, "protein_name": "Neurogenic differentiation factor 6", "gene_name": "Neurod6", "organism": "Mouse", "refseq_name": "neurogenic differentiation factor 6", "refseq_ac": "NP_033847", "gene_names_uniprotkb": "Neurod6; Ath2; Atoh2; Nex1", "gene_names_refseq": "Atoh2; Math-2; Math2; Neurod6; Nex1m; Nex; bHLHa2", "protein_names_uniprotkb": "Neurogenic differentiation factor 6; Helix-loop-helix protein mATH-2; NeuroD6; Protein NEX-1; Protein atonal homolog 2; mATH2", "protein_names_refseq": "helix-loop-helix protein mATH-2; neurogenic differentiation factor 6; protein NEX-1; protein atonal homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:11922)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7545978;7744035", "class_list": "", "function": "Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061564 axon development;GO:0021542 dentate gyrus development;GO:0007423 sensory organ development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48986-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50540-1", "uniprot_id": "MXI1_MOUSE", "mass": 25978.0, "length": 228, "protein_name": "Max-interacting protein 1", "gene_name": "Mxi1", "organism": "Mouse", "refseq_name": "max-interacting protein 1 isoform c", "refseq_ac": "NP_001008543", "gene_names_uniprotkb": "Mxi1", "gene_names_refseq": "Gm10197; Mad2; Mxi1; bHLHc11", "protein_names_uniprotkb": "Max-interacting protein 1; Max interactor 1", "protein_names_refseq": "max-interacting protein 1 isoform c; max-interacting protein 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); breast adenocarcinoma (Disease Ontology:DOID:3458); neurofibrosarcoma (Disease Ontology:DOID:3512); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (mmu:17859)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10597267;15467743;21750661;31219806;36049372;7835718;7889571;7954804;8521822;9528857", "class_list": "", "function": "Max interacting protein 1 induces IL-17-producing T helper/regulatory T imbalance in osteoarthritis by upregulating tectonic family member 2., [RefSeq, PubMed]; Mxi1-SRalpha is an isoform with enhanced transcriptional repression potential, [RefSeq, PubMed]; This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. Isoform Short, which lacks a segment, has a much stronger suppressive potential and associates with a SIN3 homologous protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P50540-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0MW30-1", "uniprot_id": "NEU1B_MOUSE", "mass": 58527.0, "length": 546, "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "Neurl1b", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase NEURL1B", "refseq_ac": "NP_001075125", "gene_names_uniprotkb": "Neurl1b; Neurl2; Neurl3", "gene_names_refseq": "C230078M08Rik; EG240055; Neurl1b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEURL1B; 2.3.2.27; NEUR2; Neuralized-2; Neuralized-like protein 1B; Neuralized-like protein 2; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL1B", "protein_names_refseq": "E3 ubiquitin-protein ligase NEURL1B; RING-type E3 ubiquitin transferase NEURL1B; neuralized homolog 1b; neuralized-like protein 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:240055)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17003037;19723503;21750661", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9DQJ8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination;GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0MW30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UQ22-1", "uniprot_id": "NET5_MOUSE", "mass": 48837.0, "length": 452, "protein_name": "Netrin-5", "gene_name": "Ntn5", "organism": "Mouse", "refseq_name": "netrin-5 isoform a precursor", "refseq_ac": "NP_001028528", "gene_names_uniprotkb": "Ntn5; Gm484", "gene_names_refseq": "Gm484; Ntn5", "protein_names_uniprotkb": "Netrin-5; Netrin-1-like protein", "protein_names_refseq": "netrin-1-like protein; netrin-5 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:243967)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;26858598", "class_list": "", "function": "Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EKG6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005604 basement membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0009887 animal organ morphogenesis;GO:0022008 neurogenesis;GO:0009888 tissue development;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UQ22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UX61-1", "uniprot_id": "NAA11_MOUSE", "mass": 24671.0, "length": 218, "protein_name": "N-alpha-acetyltransferase 11", "gene_name": "Naa11", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 11", "refseq_ac": "NP_001028363", "gene_names_uniprotkb": "Naa11; Ard1b; Ard2", "gene_names_refseq": "Ard1b; Ard2; Naa11", "protein_names_uniprotkb": "N-alpha-acetyltransferase 11; 2.3.1.255; N-terminal acetyltransferase complex ARD1 subunit homolog B; NatA catalytic subunit Naa11", "protein_names_refseq": "ARD1 homolog B; N-alpha-acetyltransferase 11; N-terminal acetyltransferase complex ARD1 subunit homolog B; Nalpha acteyltransferase 11; arrest defective 2; natA catalytic subunit Naa11", "tax_id": 10090, "disease": "Ogden syndrome (Disease Ontology:DOID:0050781)", "pathway": " (mmu:97243)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16638120;19246321;34428180", "class_list": "", "function": "Cloning, characterization, and expression pattern of Ard1b; results suggest that ARD1B may have an important role in the later course of the spermatogenic process, [RefSeq, PubMed]; Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0C7", "ec_number_list": "2.3.1.255", "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1990189 protein N-terminal-serine acetyltransferase activity;GO:1990190 protein-N-terminal-glutamate acetyltransferase activity;GO:0008999 protein-N-terminal-alanine acetyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UX61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V2Q8-1", "uniprot_id": "N42L1_MOUSE", "mass": 28038.0, "length": 238, "protein_name": "NEDD4-binding protein 2-like 1", "gene_name": "N4bp2l1", "organism": "Mouse", "refseq_name": "NEDD4-binding protein 2-like 1", "refseq_ac": "NP_598659", "gene_names_uniprotkb": "N4bp2l1", "gene_names_refseq": "2410024N18Rik; B230342M21Rik; N4bp2l1", "protein_names_uniprotkb": "NEDD4-binding protein 2-like 1", "protein_names_refseq": "NEDD4-binding protein 2-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100637)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31440585;34197691;34428180;40021952", "class_list": "", "function": "Might play a role in adipocyte differentiation and triglyceride accumulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU88;Q8BL78;Q8VE50", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3V2Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SSH8-1", "uniprot_id": "NEUFC_MOUSE", "mass": 29162.0, "length": 263, "protein_name": "Neuferricin", "gene_name": "Cyb5d2", "organism": "Mouse", "refseq_name": "neuferricin precursor", "refseq_ac": "NP_001020097", "gene_names_uniprotkb": "Cyb5d2", "gene_names_refseq": "9330151E16Rik; Cyb5d2; Gm2", "protein_names_uniprotkb": "Neuferricin; Cytochrome b5 domain-containing protein 2", "protein_names_refseq": "cytochrome b5 domain-containing protein 2; neuferricin precursor; neuferricin", "tax_id": 10090, "disease": "", "pathway": " (mmu:192986)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19968755", "class_list": "", "function": "Heme-binding protein which promotes neuronal but not astrocyte differentiation., [UniProtKB, PubMed]; This study identified neuferricin, a novel extracellular heme-binding protein with cytochrome b5-like heme/steroid-binding domain, which is the fourth member of the MAPR family in mammals. Neuferricin was abundantly expressed in the developing brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AUN6;Q0VGS6;Q8BHV3", "ec_number_list": "", "go_molecular_function": "GO:0020037 heme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SSH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SUV2-1", "uniprot_id": "MYBPP_MOUSE", "mass": 106452.0, "length": 932, "protein_name": "MYCBP-associated protein", "gene_name": "Mycbpap", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mycbpap; Amap1", "gene_names_refseq": "", "protein_names_uniprotkb": "MYCBP-associated protein; AMAM-1; AMAP-1; AMY-1-binding protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:104601)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12151104;21183079;21750661;39092789;39704931", "class_list": "", "function": "Plays a crucial role in centrosome-nuclear envelope docking during spermiogenesis, a key step for anchoring the centrosome to the nucleus that is essential for proper sperm flagellum biogenesis (PubMed:39092789). Also required for acrosome biogenesis, manchette organization and spermatid head morphogenesis, contributing to the complete and functional assembly of the sperm flagellum (PubMed:39704931)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80YS8;Q8R2Q9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0045202 synapse;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007268 chemical synaptic transmission;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SUV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69Z66-1", "uniprot_id": "MYSM1_MOUSE", "mass": 93475.0, "length": 819, "protein_name": "Deubiquitinase MYSM1", "gene_name": "Mysm1", "organism": "Mouse", "refseq_name": "deubiquitinase MYSM1", "refseq_ac": "NP_796213", "gene_names_uniprotkb": "Mysm1; Kiaa1915", "gene_names_refseq": "C130067A03Rik; C530050H10Rik; Mysm1", "protein_names_uniprotkb": "Deubiquitinase MYSM1; 2A-DUB; 3.4.19.-; Myb-like, SWIRM and MPN domain-containing protein 1", "protein_names_refseq": "2A-DUB; deubiquitinase MYSM1; histone H2A deubiquitinase MYSM1; myb-like, SWIRM and MPN domain-containing protein 1", "tax_id": 10090, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:320713); (R-MMU-5689901)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;22169041;24062447;25217698;25428506;26348977;26474655;27895164;30405132;31219806;33086059;34428180;36210013;38316548;38342917", "class_list": "", "function": "Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation., [RefSeq, PubMed]; Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression. Publication Status: Online-Only, [RefSeq, PubMed]; MYSM1 derepresses EBF1 transcription in B cell progenitors by orchestrating histone modifications and transcription factor recruitment to the EBF1 locus., [RefSeq, PubMed]; Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:26474655, PubMed:27895164, PubMed:30405132). Participates in the normal programming of B-cell responses to antigen after the maturation process (PubMed:27895164). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:26474655, PubMed:30405132). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (PubMed:26474655). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (PubMed:30405132). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:22169041, PubMed:24062447, PubMed:25217698, PubMed:26348977). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AJE3;B9EKJ6;Q3TPV7;Q8BRP5;Q8C4N1", "ec_number_list": "2.3.1.48;2.3.1.-;3.4.19.-;2.3.1.57", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0042393 histone binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q69Z66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6URW6-1", "uniprot_id": "MYH14_MOUSE", "mass": 228586.0, "length": 2000, "protein_name": "Myosin-14", "gene_name": "Myh14", "organism": "Mouse", "refseq_name": "myosin-14 isoform 1", "refseq_ac": "NP_001258467", "gene_names_uniprotkb": "Myh14", "gene_names_refseq": "2400004E04Rik; II-C; Myh14; NHMCII; NMHC II-C", "protein_names_uniprotkb": "Myosin-14; Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; NMHC II-C; Non-muscle myosin heavy chain IIc", "protein_names_refseq": "myosin heavy chain, non-muscle IIc; myosin, heavy chain 14; myosin-14 isoform 1; myosin-14; non-muscle myosin heavy chain IIc; nonmuscle myosin heavy chain", "tax_id": 10090, "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651); autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:71960); (R-MMU-5627123)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12598534;14594953;19240025;20861308;21183079;21750661;26740625;34227390;34428180;35820727;36210013", "class_list": "", "function": "A cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction, [RefSeq, PubMed]; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping., [UniProtKB]; Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B3F3T1;Q80V64;Q80ZE6", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0030424 axon;GO:0030426 growth cone;GO:0043209 myelin sheath", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0019228 neuronal action potential;GO:0030048 actin filament-based movement;GO:0031032 actomyosin structure organization;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6URW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WY3-1", "uniprot_id": "NANO1_MOUSE", "mass": 28151.0, "length": 267, "protein_name": "Nanos homolog 1", "gene_name": "Nanos1", "organism": "Mouse", "refseq_name": "nanos homolog 1", "refseq_ac": "NP_848508", "gene_names_uniprotkb": "Nanos1; Nos", "gene_names_refseq": "NOS-1; Nanos1", "protein_names_uniprotkb": "Nanos homolog 1; NOS-1", "protein_names_refseq": "nanos 1; nanos homolog 1", "tax_id": 10090, "disease": "spermatogenic failure 12 (Disease Ontology:DOID:0070171)", "pathway": " (mmu:332397)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12834871;26609159", "class_list": "", "function": "Both Nanos1 and Smaug2 function as a bimodal translational repression switch to control neurogenesis., [RefSeq, PubMed]; May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity). Not essential for normal development., [UniProtKB, PubMed]; This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2and may be involved in regulating translation as a post-transcriptional repressor. Mutations in a similar protein in human are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTS9;Q8BIJ9", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010631 epithelial cell migration;GO:0098749 cerebellar neuron development;GO:0016477 cell migration;GO:0001894 tissue homeostasis;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80WY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWZ3-1", "uniprot_id": "NAA25_MOUSE", "mass": 111708.0, "length": 972, "protein_name": "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "gene_name": "Naa25", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "refseq_ac": "NP_766310", "gene_names_uniprotkb": "Naa25; Mdm20", "gene_names_refseq": "4833422K13Rik; A630046C11; C330023M02Rik; Mdm20; Naa25", "protein_names_uniprotkb": "N-alpha-acetyltransferase 25, NatB auxiliary subunit; Mitochondrial distribution and morphology protein 20; N-terminal acetyltransferase B complex subunit MDM20; N-terminal acetyltransferase B complex subunit NAA25; NatB complex subunit MDM20", "protein_names_refseq": "N-alpha-acetyltransferase 25, NatB auxiliary subunit; N-terminal acetyltransferase B complex subunit MDM20; N-terminal acetyltransferase B complex subunit NAA25; mitochondrial distribution and morphology protein 20; natB complex subunit MDM20", "tax_id": 10090, "disease": "", "pathway": " (mmu:231713)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;22101279;22872234;25428506;29233735;30084848;31219806;34203471;34428180;35820727;36210013", "class_list": "", "function": "Mdm20 is highly expressed in the developing mouse brain., [RefSeq, PubMed]; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression., [UniProtKB, UniProtKB]; The pro-apoptotic protein Bax is main effector of mitochondrial permeabilization during apoptosis. Data suggest that Bax N-terminal acetylation by NatB is involved in mitochondrial targeting of Bax. These studies used cultured embryonic cells from knockout, transgenic, and chimeric mice. (Bax = apoptosis regulator BAX), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A4B7;Q3KQI7;Q3TJC6;Q7TMM2", "ec_number_list": "", "go_molecular_function": "GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031416 NatB complex", "go_biological_process": "GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BWZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFC2-1", "uniprot_id": "MYT1_MOUSE", "mass": 123576.0, "length": 1127, "protein_name": "Myelin transcription factor 1", "gene_name": "Myt1", "organism": "Mouse", "refseq_name": "myelin transcription factor 1 isoform 3", "refseq_ac": "NP_001165086", "gene_names_uniprotkb": "Myt1; Kiaa0835; Nzf2", "gene_names_refseq": "Myt1; Nzf2a; Nzf2b; Nzf2; Nztf2", "protein_names_uniprotkb": "Myelin transcription factor 1; MyT1; NZF-2; Neural zinc finger factor 2", "protein_names_refseq": "NZF-2; myelin transcription factor 1 isoform 3; neural zinc finger factor 2; neural zinc finger transcription factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17932)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12351189;14962745;15935060;18073212;21750661;9373037", "class_list": "", "function": "Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity)., [UniProtKB, PubMed]; Expression of Myt1 inhibited the differentiation of progenitors into oligodendrocytes as assessed by morphology, immunostaining, and myelin gene expression. Progenitor differentiation was similarly inhibited by expression of Myt1., [RefSeq, PubMed]; In embryonic mouse nervous system, the expression of NZF-2b starts as early as at 9.5 days post-coitum (dpc) in newly differentiated neurons in the central nervous system (CNS) and the peripheral nervous system (PNS), [RefSeq, PubMed]; The Myt1 family of zinc finger proteins, when bound to a neural promoter, can recruit Sin3B. Depending on the relative availability of Sin3B isoforms, the Myt1 gene family may favor the silencing of genes during neural development., [RefSeq, PubMed]; This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B0R0C3;B0R0C4;O08995;Q8CFH1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CFC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIQ6-1", "uniprot_id": "MTR1B_MOUSE", "mass": 40261.0, "length": 364, "protein_name": "Melatonin receptor type 1B", "gene_name": "Mtnr1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mtnr1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "acute pancreatitis (Disease Ontology:DOID:2913); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-MMU-373076); (R-MMU-418594)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12679517", "class_list": "", "function": "High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80T38;Q8K3K0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008502 melatonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0007186 G protein-coupled receptor signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0042593 glucose homeostasis;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CIQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4U1-1", "uniprot_id": "MYPOP_MOUSE", "mass": 41890.0, "length": 393, "protein_name": "Myb-related transcription factor, partner of profilin", "gene_name": "Mypop", "organism": "Mouse", "refseq_name": "myb-related transcription factor, partner of profilin isoform 1", "refseq_ac": "NP_663554", "gene_names_uniprotkb": "Mypop; P42pop", "gene_names_refseq": "Myodysa; Mypop; P42pop", "protein_names_uniprotkb": "Myb-related transcription factor, partner of profilin; Myb-related protein p42POP; Partner of profilin", "protein_names_refseq": "Myb protein P42POP; myb-related protein p42POP; myb-related transcription factor, partner of profilin isoform 1; myotonic dystrophy region; partner of profilin", "tax_id": 10090, "disease": "", "pathway": " (mmu:232934)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15615774;31219806;32848054", "class_list": "", "function": "Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity., [UniProtKB, PubMed]; We describe a novel Myb-related transcription factor, p42POP, as a new ligand for profilin and show that profilin regulates its activity. p42POP comprises a unique combination of domains and is widely expressed in mouse tissues, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNR1;Q8CFP0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R4U1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JT9-1", "uniprot_id": "MTND_MOUSE", "mass": 21524.0, "length": 179, "protein_name": "Acireductone dioxygenase", "gene_name": "Adi1", "organism": "Mouse", "refseq_name": "acireductone dioxygenase", "refseq_ac": "NP_598813", "gene_names_uniprotkb": "Adi1; Mtcbp1", "gene_names_refseq": "ARD'; Adi1; Fe-ARD; MTCBP-1; Ni-ARD", "protein_names_uniprotkb": "Acireductone dioxygenase; 1.13.11.53; 1.13.11.54; ARD'; ARD; Acireductone dioxygenase (Fe(2+)-requiring); Acireductone dioxygenase (Ni(2+)-requiring); Fe-ARD; MTCBP-1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; Ni-ARD", "protein_names_refseq": "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; ARD; aci-reductone dioxygenase; acireductone dioxygenase (Fe(2+)-requiring); acireductone dioxygenase (Ni(2+)-requiring); acireductone dioxygenase; fe-ARD; membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:104923); (R-MMU-1237112)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16783794;26858196", "class_list": "", "function": "Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (PubMed:26858196). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:26858196). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (PubMed:26858196). Also down-regulates cell migration mediated by MMP14 (By similarity)., [UniProtKB, PubMed, HAMAP]; Crystal structure of acireductone dioxygenase (ARD) was determined to 2.06 A resolution using the multi-wavelength anomalous diffraction (MAD) method and the structure show nine beta-strands, five helices, and a metal-binding site inside the -barrel., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.13.11.54;1.13.11.53", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0016151 nickel cation binding;GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity;GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine;GO:0006555 methionine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99JT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MD8-1", "uniprot_id": "MYNN_MOUSE", "mass": 68593.0, "length": 610, "protein_name": "Myoneurin", "gene_name": "Mynn", "organism": "Mouse", "refseq_name": "myoneurin isoform 2", "refseq_ac": "NP_001276550", "gene_names_uniprotkb": "Mynn", "gene_names_refseq": "2810011C24Rik; Mynn; Mynr; SBBIZ1", "protein_names_uniprotkb": "Myoneurin", "protein_names_refseq": "myoneurin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80732)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10873615;14694499;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1G7;Q8BT55;Q922I4;Q9CSA0;Q9CXJ8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99MD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPU2-1", "uniprot_id": "NDUB2_MOUSE", "mass": 11967.0, "length": 105, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial", "gene_name": "Ndufb2", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor", "refseq_ac": "NP_080888", "gene_names_uniprotkb": "Ndufb2", "gene_names_refseq": "1810011O01Rik; 8kDa; AGGG; CI-AGGG; Ndufb2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; CI-AGGG; Complex I-AGGG; NADH-ubiquinone oxidoreductase AGGG subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; NADH-ubiquinone oxidoreductase AGGG subunit; complex I-AGGG", "tax_id": 10090, "disease": "", "pathway": " (mmu:68198); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "34428180;36288343;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:38575788). Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:38575788). The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:38575788)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CPU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ25-1", "uniprot_id": "MZT2_MOUSE", "mass": 16524.0, "length": 159, "protein_name": "Mitotic-spindle organizing protein 2", "gene_name": "Mzt2", "organism": "Mouse", "refseq_name": "mitotic-spindle organizing protein 2", "refseq_ac": "NP_083630", "gene_names_uniprotkb": "Mzt2; Fam128b; Mozart2", "gene_names_refseq": "2410018G20Rik; 2610001E06Rik; Fam128b; Fam128; Mzt2", "protein_names_uniprotkb": "Mitotic-spindle organizing protein 2; Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B", "protein_names_refseq": "family with sequence similarity 128, member B; mitotic-spindle organizing protein 2; mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B; mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72083); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;20360068;21750661;24129315;32848054;36852467;40885482", "class_list": "", "function": "Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0000931 gamma-tubulin ring complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CQ25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQC7-1", "uniprot_id": "NDUB4_MOUSE", "mass": 15081.0, "length": 129, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "gene_name": "Ndufb4", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "refseq_ac": "NP_080886", "gene_names_uniprotkb": "Ndufb4", "gene_names_refseq": "0610006N12Rik; 1300010H20Rik; CI-B15; Ndufb4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; CI-B15; Complex I-B15; NADH-ubiquinone oxidoreductase B15 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; NADH:ubiquinone oxidoreductase B15 subunit; complex I-B15", "tax_id": 10090, "disease": "", "pathway": " (mmu:68194); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21183079;26495903;33300544;34428180;36288343;37453647;37507081;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8I1-1", "uniprot_id": "MZB1_MOUSE", "mass": 20580.0, "length": 188, "protein_name": "Marginal zone B- and B1-cell-specific protein", "gene_name": "Mzb1", "organism": "Mouse", "refseq_name": "marginal zone B- and B1-cell-specific protein precursor", "refseq_ac": "NP_081498", "gene_names_uniprotkb": "Mzb1; Pacap", "gene_names_refseq": "2010001M09Rik; Mzb1; PACAP; pERp1", "protein_names_uniprotkb": "Marginal zone B- and B1-cell-specific protein; Plasma cell-induced resident ER protein; Plasma cell-induced resident endoplasmic reticulum protein; Proapoptotic caspase adapter protein; pERp1", "protein_names_refseq": "marginal zone B- and B1-cell-specific protein precursor; marginal zone B- and B1-cell-specific protein; plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69816)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11465105;19395375;19805154;19805157;21093319;21688198;21750661;25428506;26495903;28011936;31127044;32069316;32759964;33318509;34428180;38101774", "class_list": "", "function": "Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance., [UniProtKB]; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation., [UniProtKB]; Data suggest that pERp1 is either a unique type of oxidoreductase or a previously unidentified class of molecular chaperone that is dedicated to enhancing the oxidative folding of Ig precursors., [RefSeq, PubMed]; In a mouse model of asthma 2010001M09Rik (Mzb1) was unaltered 24 hours after allergen exposure, however, by 72 hours a marked increase in 2010001M09Rik mRNA was detected in lung tissue from disease-susceptible C57BL/6 and BALB/c mice., [RefSeq, PubMed]; MZB1 enables efficient interferon alpha secretion in stimulated plasmacytoid dendritic cells. Publication Status: Online-Only, [RefSeq, PubMed]; MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation., [RefSeq, PubMed]; Mzb1 helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation., [RefSeq, PubMed]; Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation., [RefSeq, PubMed]; Promotes secretion of J-chain-containing dimeric IgA and is critical for suppression of gut inflammation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2IYS1;Q6P3D3;Q8BU13;Q8K2M5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0030888 regulation of B cell proliferation;GO:0033622 integrin activation;GO:0046626 regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D8I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAT5-1", "uniprot_id": "MTU1_MOUSE", "mass": 47240.0, "length": 417, "protein_name": "Mitochondrial tRNA-specific 2-thiouridylase 1", "gene_name": "Trmu", "organism": "Mouse", "refseq_name": "mitochondrial tRNA-specific 2-thiouridylase 1", "refseq_ac": "NP_082339", "gene_names_uniprotkb": "Trmu; Mtu1; Trmt1", "gene_names_refseq": "1110005N20Rik; 1600025P05Rik; Mtu1; Trmt1; Trmu", "protein_names_uniprotkb": "Mitochondrial tRNA-specific 2-thiouridylase 1; 2.8.1.14", "protein_names_refseq": "mitochondrial tRNA-specific 2-thiouridylase 1; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1", "tax_id": 10090, "disease": "infantile liver failure syndrome (Disease Ontology:DOID:0080716); transient infantile liver failure (Disease Ontology:DOID:0080778); aminoglycoside-induced deafness (Disease Ontology:DOID:0111734); inner ear disease (Disease Ontology:DOID:2952); MERRF syndrome (Disease Ontology:DOID:310); liver disease (Disease Ontology:DOID:409)", "pathway": " (mmu:72026)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14746906;21750661;34428180;37507081", "class_list": "", "function": "Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base., [UniProtKB, UniProtKB]; Plays a role in mitochondrial tRNA modification pathway and the pathogenesis of mitochondrial disorders, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.1.14", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0061708 tRNA-5-taurinomethyluridine 2-sulfurtransferase", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DAT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB73-1", "uniprot_id": "NB5R1_MOUSE", "mass": 34135.0, "length": 305, "protein_name": "NADH-cytochrome b5 reductase 1", "gene_name": "Cyb5r1", "organism": "Mouse", "refseq_name": "NADH-cytochrome b5 reductase 1 isoform 1", "refseq_ac": "NP_082333", "gene_names_uniprotkb": "Cyb5r1; Nqo3a2", "gene_names_refseq": "1500005G05Rik; B5R.1; Cyb5r1; Nqo3a2", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 1; 1.6.2.2; NAD(P)H:quinone oxidoreductase type 3 polypeptide A2; b5R.1", "protein_names_refseq": "NAD(P)H:quinone oxidoreductase type 3, polypeptide A2; NADH-cytochrome b5 reductase 1 isoform 1; NADH-cytochrome b5 reductase 1", "tax_id": 10090, "disease": "methemoglobinemia (Disease Ontology:DOID:10783)", "pathway": " (mmu:72017); (R-MMU-114608); (R-MMU-1237044)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;33321093;37828378", "class_list": "glycogene", "function": "Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor., [UniProtKB, UniProtKB]; Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W81", "ec_number_list": "1.6.2.2;5.3.4.1", "go_molecular_function": "GO:0071949 FAD binding;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DB73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQH7-1", "uniprot_id": "NDST3_MOUSE", "mass": 101040.0, "length": 873, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3", "gene_name": "Ndst3", "organism": "Mouse", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform 2", "refseq_ac": "NP_001280611", "gene_names_uniprotkb": "Ndst3; Hsst3", "gene_names_refseq": "4921531K01Rik; 4930511P15Rik; N-HSST 3; NDST-3; Ndst3", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 3; N-HSST 3; N-heparan sulfate sulfotransferase 3; NDST-3", "protein_names_refseq": "N-heparan sulfate sulfotransferase 3; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform 2; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; glucosaminyl N-deacetylase/N-sulfotransferase 3", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (mmu:83398); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11087757;16056228;21750661;29688404;34428180", "class_list": "glycogene", "function": "An essential role for Heparin sulfate proteoglycan sulfation via NDST1,2,3 in modulating signal transduction during mouse implantation., [RefSeq, PubMed]; Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 50, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXE0;Q9D557", "ec_number_list": "2.8.2.-;3.-.-.-;2.8.2.8;3.5.1.-", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0050119 N-acetylglucosamine deacetylase activity;GO:0102140 heparan sulfate N-deacetylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EQH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIY7-1", "uniprot_id": "NAT8_MOUSE", "mass": 25638.0, "length": 227, "protein_name": "N-acetyltransferase 8", "gene_name": "Nat8", "organism": "Mouse", "refseq_name": "N-acetyltransferase 8", "refseq_ac": "NP_075944", "gene_names_uniprotkb": "Nat8; Cml4", "gene_names_refseq": "0610037O16Rik; ATase2; CCNAT; Cml4; Nat8", "protein_names_uniprotkb": "N-acetyltransferase 8; 2.3.1.-; 2.3.1.80; ATase2; Acetyltransferase 2; CCNAT; Camello-like protein 4; Cysteinyl-conjugate N-acetyltransferase; Protein-lysine N6-acetyltransferase 8", "protein_names_refseq": "N-acetyltransferase 8 (GCN5-related, putative); N-acetyltransferase 8; acetyltransferase 2; camello-like 4; camello-like protein 4; cysteinyl-conjugate N-acetyltransferase; probable N-acetyltransferase CML4; protein-lysine N6-acetyltransferase 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:68396)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11397015;22267734;25057902;33846551;34428180;39145457", "class_list": "", "function": "Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (By similarity). N(6)-lysine acetylation in the ER maintains protein homeostasis and regulates reticulophagy (PubMed:33846551). Alternatively, acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results show that Nat8 is down-regulated in liver ischemia/reperfusion injury and its upregulation prevents it suggesting its protective effect against liver injuries. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.3.1.-;2.7.11.1;2.3.1.259;2.3.1.57;2.3.1.80;4.2.1.-", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0010628 positive regulation of gene expression;GO:0001702 gastrulation with mouth forming second;GO:0018003 peptidyl-lysine N6-acetylation;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JIY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QWR8-1", "uniprot_id": "NAGAB_MOUSE", "mass": 47235.0, "length": 415, "protein_name": "Alpha-N-acetylgalactosaminidase", "gene_name": "Naga", "organism": "Mouse", "refseq_name": "alpha-N-acetylgalactosaminidase isoform 1 precursor", "refseq_ac": "NP_032695", "gene_names_uniprotkb": "Naga", "gene_names_refseq": "Naga", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminidase; 3.2.1.49; Alpha-galactosidase B", "protein_names_refseq": "alpha-N-acetylgalactosaminidase isoform 1 precursor; alpha-N-acetylgalactosaminidase; alpha-galactosidase B", "tax_id": 10090, "disease": "Schindler disease type 1 (Disease Ontology:DOID:0112318); Kanzaki disease (Disease Ontology:DOID:0112319); Fabry disease (Disease Ontology:DOID:14499); neuroaxonal dystrophy (Disease Ontology:DOID:2367); angiokeratoma (Disease Ontology:DOID:479)", "pathway": " (mmu:17939)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11471062;19853240;21750661;25428506;26740625;30084848;30899004;33300544;9602128;9787108", "class_list": "glycogene;glycosylhydrolase", "function": "Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Use of a modified Naga in the development of enzyme replacement therapy for Fabry disease is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88620;Q8R437;Q8VDK2", "ec_number_list": "3.2.1.-;3.2.1.49", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004557 alpha-galactosidase activity;GO:0008456 alpha-N-acetylgalactosaminidase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0019377 glycolipid catabolic process;GO:0016052 carbohydrate catabolic process;GO:0009311 oligosaccharide metabolic process;GO:0016139 glycoside catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QWR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88685-1", "uniprot_id": "PRS6A_MOUSE", "mass": 49549.0, "length": 442, "protein_name": "26S proteasome regulatory subunit 6A", "gene_name": "Psmc3", "organism": "Mouse", "refseq_name": "26S proteasome regulatory subunit 6A", "refseq_ac": "NP_032974", "gene_names_uniprotkb": "Psmc3; Tbp1", "gene_names_refseq": "Psmc3; TBP-1", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; TBP-1; Tat-binding protein 1", "protein_names_refseq": "26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; 26S proteasome regulatory subunit 6A; TAT-binding protein 1; Tat binding protein 1; proteasome 26S subunit ATPase 3", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); sensorineural hearing loss (Disease Ontology:DOID:10003); cataract (Disease Ontology:DOID:83); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19182); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10945464;16857966;21750661;22078707;26740625;31219806;34428180;37256937;39627609;9714759", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99JN8", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0043921 host-mediated perturbation of viral transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0001824 blastocyst development;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61096-1", "uniprot_id": "PRTN3_MOUSE", "mass": 27626.0, "length": 254, "protein_name": "Myeloblastin", "gene_name": "Prtn3", "organism": "Mouse", "refseq_name": "myeloblastin precursor", "refseq_ac": "NP_035308", "gene_names_uniprotkb": "Prtn3", "gene_names_refseq": "PR-3; PR3; Prtn3; mPR3", "protein_names_uniprotkb": "Myeloblastin; 3.4.21.76; PR-3; Proteinase 3", "protein_names_refseq": "myeloblastin precursor; myeloblastin", "tax_id": 10090, "disease": "", "pathway": " (mmu:19152); (R-MMU-6798695); (R-MMU-6803157); (R-MMU-9769739)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "21750661;32002713;32403136;34428180;36944270;38589495;9187364;9211743;9925946", "class_list": "", "function": "Lack of Proteinase 3 Stabilizes Advanced Atherosclerotic Lesions., [RefSeq, PubMed]; Mice Deficient in the IL-1beta Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD., [RefSeq, PubMed]; N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis., [RefSeq, PubMed]; Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation., [RefSeq, PubMed]; Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08809", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft;GO:0035578 azurophil granule lumen", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0043547 positive regulation of GTPase activity;GO:0050765 negative regulation of phagocytosis;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61096-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28076-1", "uniprot_id": "PSB9_MOUSE", "mass": 23397.0, "length": 219, "protein_name": "Proteasome subunit beta type-9", "gene_name": "Psmb9", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-9 isoform 1", "refseq_ac": "NP_038613", "gene_names_uniprotkb": "Psmb9; Lmp2; Ring12", "gene_names_refseq": "Lmp-2; Lmp2; Psmb9; Ring12", "protein_names_uniprotkb": "Proteasome subunit beta type-9; 3.4.25.1; LMP-2d; Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 protein", "protein_names_refseq": "LMP-2d; large multifunctional protease 2; low molecular mass protein 2; macropain chain 7; multicatalytic endopeptidase complex chain 7; proteasome chain 7; proteasome subunit beta type-9 isoform 1; proteasome subunit beta type-9; proteasome subunit beta-1i; proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteosome beta 9 subunit; really interesting new gene 12 protein", "tax_id": 10090, "disease": "lymphoma (Disease Ontology:DOID:0060058); colorectal carcinoma (Disease Ontology:DOID:0080199); adult respiratory distress syndrome (Disease Ontology:DOID:11394); vitiligo (Disease Ontology:DOID:12306); Huntington's disease (Disease Ontology:DOID:12858); peptic esophagitis (Disease Ontology:DOID:13976); multiple sclerosis (Disease Ontology:DOID:2377); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); ankylosing spondylitis (Disease Ontology:DOID:7147); autoimmune thyroiditis (Disease Ontology:DOID:7188); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:16912); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-9907900); (R-MMU-9912633)", "pathway_count": 5, "publication_count": 30, "publication_id_list": "15907481;16222703;16452686;1681432;16857966;17142736;19224205;20173027;21750661;21952136;22341445;22872234;23706739;25428506;25428507;30084848;30779550;31219806;31599954;34132031;34203471;34547302;34819510;35820727;7681985;7901128;8325639;8575819;8672125;8854085", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; Expression of immunoproteasome subunits in the brains of Toxoplasma gondii-infected mice., [RefSeq, PubMed]; Heterozygous missense variant of the proteasome subunit beta-type 9 causes neonatal-onset autoinflammation and immunodeficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Immunoproteasome impairment via beta5i/LMP7-deletion leads to sustained pancreatic injury from experimental pancreatitis., [RefSeq, PubMed]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Contributes to NFKBIA degradation and subsequently NFKB1 generation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09085;O09151;Q07704;Q60827;Q64278", "ec_number_list": "3.4.25.1", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0070628 proteasome binding;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009617 response to bacterium;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0019882 antigen processing and presentation;GO:0002376 immune system process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P28076-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPN9-1", "uniprot_id": "PRR14_MOUSE", "mass": 67811.0, "length": 612, "protein_name": "Proline-rich protein 14", "gene_name": "Prr14", "organism": "Mouse", "refseq_name": "proline-rich protein 14", "refseq_ac": "NP_663564", "gene_names_uniprotkb": "Prr14", "gene_names_refseq": "Prr14", "protein_names_uniprotkb": "Proline-rich protein 14", "protein_names_refseq": "proline-rich protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:233895)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25906157;36852467;40997131", "class_list": "", "function": "Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (By similarity). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (By similarity). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (By similarity) (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q922N8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0005652 nuclear lamina", "go_biological_process": "GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TPN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6X6-1", "uniprot_id": "PRS23_MOUSE", "mass": 43071.0, "length": 382, "protein_name": "Serine protease 23", "gene_name": "Prss23", "organism": "Mouse", "refseq_name": "serine protease 23 precursor", "refseq_ac": "NP_083890", "gene_names_uniprotkb": "Prss23", "gene_names_refseq": "2310046G15Rik; 4930479H08Rik; Prss23; Spuve", "protein_names_uniprotkb": "Serine protease 23; 3.4.21.-", "protein_names_refseq": "protease, serine 23; serine protease 23 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:76453); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16870946;18566130;21750661;25428506;29016706;31219806;37828378;38157023", "class_list": "", "function": "HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia, [RefSeq, PubMed]; Prss23 mRNA levels decreased transiently after ovulation induction and again in the postovulatory period, [RefSeq, PubMed]; Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis., [RefSeq, PubMed]; Suggest a pivotal role for miR-532-prss23 axis in regulating cardiac endothelial cell function after myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q544M8;Q8VEG1", "ec_number_list": "3.4.24.81;3.6.4.-;5.3.4.1;3.4.21.69;2.7.11.1;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.4.21.-;2.4.1.145;3.1.1.4;3.1.1.3;1.8.3.2;3.1.1.98;3.2.1.51;3.4.21.112", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D6X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DJE0-1", "uniprot_id": "PT100_MOUSE", "mass": 9410.0, "length": 76, "protein_name": "Protein PET100 homolog, mitochondrial", "gene_name": "Pet100", "organism": "Mouse", "refseq_name": "protein PET100 homolog, mitochondrial", "refseq_ac": "NP_001182173", "gene_names_uniprotkb": "Pet100", "gene_names_refseq": "2900053A13Rik; Pet100", "protein_names_uniprotkb": "Protein PET100 homolog, mitochondrial", "protein_names_refseq": "protein PET100 homolog, mitochondrial", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 12 (Disease Ontology:DOID:0070498)", "pathway": " (mmu:100503890)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22356826;34428180", "class_list": "", "function": "Plays a role in mitochondrial complex IV assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DJE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54775-1", "uniprot_id": "PRS6B_MOUSE", "mass": 47408.0, "length": 418, "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "Psmc4", "organism": "Mouse", "refseq_name": "26S proteasome regulatory subunit 6B", "refseq_ac": "NP_036004", "gene_names_uniprotkb": "Psmc4; Tbp7", "gene_names_refseq": "CIP21; MIP224; Psmc4", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; CIP21; MB67-interacting protein; MIP224; Proteasome 26S subunit ATPase 4; TBP-7; Tat-binding protein 7", "protein_names_refseq": "26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; MB67-interacting protein; TAT-binding protein 7; TBP-7; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:23996); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 56, "publication_count": 14, "publication_id_list": "10945464;16857966;21750661;25428506;30084848;31219806;33300544;34203471;34428180;35820727;36210013;37507081;37828378;8603043", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWN9", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0001824 blastocyst development;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P54775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQW3-1", "uniprot_id": "PROZ_MOUSE", "mass": 44304.0, "length": 399, "protein_name": "Vitamin K-dependent protein Z", "gene_name": "Proz", "organism": "Mouse", "refseq_name": "vitamin K-dependent protein Z isoform 1 precursor", "refseq_ac": "NP_080110", "gene_names_uniprotkb": "Proz", "gene_names_refseq": "1300015B06Rik; Proz", "protein_names_uniprotkb": "Vitamin K-dependent protein Z", "protein_names_refseq": "vitamin K-dependent protein Z isoform 1 precursor; vitamin K-dependent protein Z", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); Behcet's disease (Disease Ontology:DOID:13241); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:66901); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782); (R-MMU-9769739)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17330941;18344422;21750661;23205927;25337252;26495903", "class_list": "", "function": "Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity)., [UniProtKB]; Letter: protein Z is not a typical acute phase reactant., [RefSeq, PubMed]; PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype., [RefSeq, PubMed]; PZ contributes to a reduced neointima formation after vascular injury, underlining the modulatory role of the coagulation cascade in vascular homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28828-1", "uniprot_id": "PTPRM_MOUSE", "mass": 163653.0, "length": 1452, "protein_name": "Receptor-type tyrosine-protein phosphatase mu", "gene_name": "Ptprm", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase mu isoform 5 precursor", "refseq_ac": "NP_033010", "gene_names_uniprotkb": "Ptprm; Kiaa4044", "gene_names_refseq": "Ptprm; RPTPmu; mKIAA4044", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase mu; 3.1.3.48; Protein-tyrosine phosphatase mu; R-PTP-mu", "protein_names_refseq": "R-PTP-mu; protein-tyrosine phosphatase mu; receptor-type tyrosine-protein phosphatase mu isoform 5 precursor; receptor-type tyrosine-protein phosphatase mu", "tax_id": 10090, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (mmu:19274)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;1655529;21750661;25428506;30084848;30899004;34428180;36210013", "class_list": "", "function": "Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation. Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E9QKU4;Q571L8", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0042802 identical protein binding;GO:0045296 cadherin binding;GO:0005001 transmembrane receptor protein tyrosine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0030027 lamellipodium", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0007165 signal transduction;GO:0031175 neuron projection development;GO:0042311 vasodilation;GO:0001937 negative regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P28828-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JI4-1", "uniprot_id": "PSMD6_MOUSE", "mass": 45536.0, "length": 389, "protein_name": "26S proteasome non-ATPase regulatory subunit 6", "gene_name": "Psmd6", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 6", "refseq_ac": "NP_079826", "gene_names_uniprotkb": "Psmd6", "gene_names_refseq": "2400006A19Rik; Psmd6", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 6; 26S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; p42A", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 6; 26S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; p42A; proteasome, 26S, non-ATPase regulatory subunit 6", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:66413); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 9, "publication_id_list": "16857966;20484733;21750661;22872234;25428506;30779550;34428180;35820727;37828378", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWZ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99JI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PW4-1", "uniprot_id": "PRPKB_MOUSE", "mass": 27394.0, "length": 244, "protein_name": "EKC/KEOPS complex subunit Tp53rkb", "gene_name": "Tp53rkb; Trp53rkb", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tp53rkb; Trp53rkb; Prpk; Tp53rk; Trp53rkb; Trp53rk", "gene_names_refseq": "", "protein_names_uniprotkb": "EKC/KEOPS complex subunit Tp53rkb; 2.7.11.1; 3.6.-.-; Atypical serine/threonine protein kinase Tp53rk; EKC/KEOPS complex subunit Tp53rk; Nori-2; TP53-regulating kinase; p53-related protein kinase", "protein_names_refseq": "", "tax_id": 10090, "disease": "Galloway-Mowat syndrome 4 (Disease Ontology:DOID:0080246)", "pathway": " (R-MMU-6804756)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11546806;21750661", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W37;Q9CZ32", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99PW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A8L5-1", "uniprot_id": "PTPRF_MOUSE", "mass": 211489.0, "length": 1898, "protein_name": "Receptor-type tyrosine-protein phosphatase F", "gene_name": "Ptprf", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase F precursor", "refseq_ac": "NP_035343", "gene_names_uniprotkb": "Ptprf; Lar", "gene_names_refseq": "LARS; LAR; Ptprf; RPTP-LAR", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase F; 3.1.3.48; LAR; Leukocyte common antigen related", "protein_names_refseq": "Receptor-type tyrosine-protein phosphatase F; leukocyte antigen-related (LAR) PTP receptor; leukocyte common antigen related; receptor-type tyrosine-protein phosphatase F precursor", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); hyperinsulinism (Disease Ontology:DOID:2018); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19268); (R-MMU-388844); (R-MMU-77387); (R-MMU-8849932)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11241288;19349973;21402080;21750661;30899004;33656439;34418053;34428180;35820727;36210013;38139460", "class_list": "", "function": "Intact synapse structure and function after combined knockout of PTPdelta, PTPsigma, and LAR. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-199a-3p Regulates the PTPRF/beta-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata. Publication Status: Online-Only, [RefSeq, PubMed]; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 3, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG86;Q9EQ17", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.10.1;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0005158 insulin receptor binding;GO:0008201 heparin binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005768 endosome;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0060076 excitatory synapse", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0048679 regulation of axon regeneration;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "A2A8L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ADA5-1", "uniprot_id": "PUSL1_MOUSE", "mass": 31993.0, "length": 291, "protein_name": "tRNA pseudouridine synthase-like 1", "gene_name": "Pusl1", "organism": "Mouse", "refseq_name": "tRNA pseudouridine synthase-like 1", "refseq_ac": "NP_001028662", "gene_names_uniprotkb": "Pusl1", "gene_names_refseq": "2810021I11Rik; Pusl1", "protein_names_uniprotkb": "tRNA pseudouridine synthase-like 1; 5.4.99.12; tRNA pseudouridine (38/39/40) synthase-like 1; tRNA pseudouridylate synthase-like 1; tRNA-uridine isomerase-like 1", "protein_names_refseq": "tRNA pseudouridine synthase-like 1; tRNA pseudouridylate synthase-like 1; tRNA-uridine isomerase-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:433813)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31693908", "class_list": "", "function": "MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition., [RefSeq, PubMed]; Pseudouridylate synthase that catalyzes the conversion of uridine to pseudouridine in mitochondrial tRNAs. Acts on position 38/39/40 in the anticodon stem of mitochondrial tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVB3;Q3UAA3", "ec_number_list": "5.4.99.12;5.4.99.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0106029 tRNA pseudouridine synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ADA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AFE9-1", "uniprot_id": "PRR32_MOUSE", "mass": 30901.0, "length": 284, "protein_name": "Proline-rich protein 32", "gene_name": "Prr32", "organism": "Mouse", "refseq_name": "proline-rich protein 32", "refseq_ac": "NP_081117", "gene_names_uniprotkb": "Prr32", "gene_names_refseq": "1110059M19Rik; Prr32", "protein_names_uniprotkb": "Proline-rich protein 32", "protein_names_refseq": "proline-rich protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:68800)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0W7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2AFE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ALK8-1", "uniprot_id": "PTN3_MOUSE", "mass": 103896.0, "length": 913, "protein_name": "Tyrosine-protein phosphatase non-receptor type 3", "gene_name": "Ptpn3", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 3", "refseq_ac": "NP_035337", "gene_names_uniprotkb": "Ptpn3", "gene_names_refseq": "9530011I20Rik; PTP-H1; PTPCL; Ptpn3", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 3; 3.1.3.48", "protein_names_refseq": "protein-tyrosine phosphatase H1; tyrosine-protein phosphatase non-receptor type 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:545622); (R-MMU-182971); (R-MMU-5675221)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17921143;19107198;21750661;22730326;34428180", "class_list": "", "function": "May act at junctions between the membrane and the cytoskeleton., [UniProtKB]; P38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response., [RefSeq, PubMed]; PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion, [RefSeq, PubMed]; PTPN3 and PTPN4 are dispensable for TCR signal transduction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.11.24;2.3.2.27;2.7.10.1;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0008092 cytoskeletal protein binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0045930 negative regulation of mitotic cell cycle;GO:0098902 regulation of membrane depolarization during action potential;GO:1902305 regulation of sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2ALK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06348-1", "uniprot_id": "PRRX2_MOUSE", "mass": 26427.0, "length": 247, "protein_name": "Paired mesoderm homeobox protein 2", "gene_name": "Prrx2", "organism": "Mouse", "refseq_name": "paired mesoderm homeobox protein 2", "refseq_ac": "NP_033142", "gene_names_uniprotkb": "Prrx2; Prx2; S8", "gene_names_refseq": "Prrx2; Prx2; S8", "protein_names_uniprotkb": "Paired mesoderm homeobox protein 2; Homeobox protein S8; PRX-2", "protein_names_refseq": "PRX-2; homeo box of paired rule; homeobox protein S8; paired mesoderm homeobox protein 2; surface antigen, homeo box of paired rule", "tax_id": 10090, "disease": "", "pathway": " (mmu:20204)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1680375;21750661;2901346;35452748;37081396", "class_list": "", "function": "Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Peroxiredoxin 2 deletion impairs hippocampal-dependent memory via exacerbating transient ischemia-induced oxidative damage., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61651", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:2000648 positive regulation of stem cell proliferation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042472 inner ear morphogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q06348-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5R2-1", "uniprot_id": "PRSR2_MOUSE", "mass": 50421.0, "length": 471, "protein_name": "Proline and serine-rich protein 2", "gene_name": "Proser2", "organism": "Mouse", "refseq_name": "proline and serine-rich protein 2", "refseq_ac": "NP_001153129", "gene_names_uniprotkb": "Proser2; 5430407P10Rik", "gene_names_refseq": "5430407P10Rik; Proser2", "protein_names_uniprotkb": "Proline and serine-rich protein 2", "protein_names_refseq": "proline and serine-rich protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227545)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;32782141;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1L9;Q8R017;Q8R2Z9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C5R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64455-1", "uniprot_id": "PTPRJ_MOUSE", "mass": 136769.0, "length": 1238, "protein_name": "Receptor-type tyrosine-protein phosphatase eta", "gene_name": "Ptprj", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase eta isoform 1 precursor", "refseq_ac": "NP_033008", "gene_names_uniprotkb": "Ptprj; Byp; Scc1", "gene_names_refseq": "BET; Byp; CD148; DEP-1; PTPbeta2; Ptpb2; Ptprj; R-PTP-J; R-PTP-eta; RPTPJ; Scc-1; Scc1", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase eta; 3.1.3.48; HPTP beta-like tyrosine phosphatase; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; R-PTP-eta; Susceptibility to colon cancer 1", "protein_names_refseq": "HPTP beta-like tyrosine phosphatase; colon tumor susceptibility 1; protein-tyrosine phosphatase eta; receptor-type tyrosine-protein phosphatase eta isoform 1 precursor; receptor-type tyrosine-protein phosphatase eta; susceptibility to colon cancer 1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); thrombocytopenia (Disease Ontology:DOID:1588); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:19271); (R-MMU-202427); (R-MMU-6798695); (R-MMU-6807004); (R-MMU-9706369)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;12089527;12588999;12771128;12833140;12913111;18249142;19246339;19268662;19349973;21750661;26495903;26740625;28011936;30899004;31219806;33605542;33784491;34428180;37875230;8483328;8549806;9823776", "class_list": "", "function": "CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis., [RefSeq, PubMed]; High-fat diet alters N-glycosylation of PTPRJ in murine liver., [RefSeq, PubMed]; PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis., [RefSeq, PubMed]; Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (By similarity). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:18249142). Has a role in megakaryocytes and platelet formation. Involved in vascular development (PubMed:12588999). May be involved in the mechanism of contact inhibition of cell growth (PubMed:12771128). Regulator of macrophage adhesion and spreading (PubMed:19268662). Positively affects cell-matrix adhesion (PubMed:12833140). Positive regulator of platelet activation and thrombosis (PubMed:19246339). Negative regulator of cell proliferation (By similarity). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:12833140). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (By similarity). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (By similarity). Enhances the barrier function of epithelial junctions during reassembly (By similarity). Negatively regulates T-cell receptor (TCR) signaling (By similarity). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:12913111)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 16, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 21, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 21, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 21, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 21, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 24, "disease_count": 5, "glyco_site_count": 38, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH64;Q3UHL5;Q541R5;Q8CIW9;Q8K3Q2", "ec_number_list": "3.1.3.48;2.3.2.27;7.6.2.1;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;2.7.10.2;3.4.21.73;2.7.10.1;2.7.10.4;3.6.5.2;1.1.1.-;3.4.24.-;2.3.1.78;1.6.3.-;3.2.2.6;3.1.3.27;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.1.3.5;3.1.3.21;3.1.3.18;2.3.1.51;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0051019 mitogen-activated protein kinase binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:2000272 negative regulation of signaling receptor activity;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0001570 vasculogenesis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 6.9, "record_id": "Q64455-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8W5-1", "uniprot_id": "PSD12_MOUSE", "mass": 52895.0, "length": 456, "protein_name": "26S proteasome non-ATPase regulatory subunit 12", "gene_name": "Psmd12", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 12", "refseq_ac": "NP_080170", "gene_names_uniprotkb": "Psmd12", "gene_names_refseq": "1500002F15Rik; P55; Psmd12", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:66997); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 12, "publication_id_list": "16857966;20484733;21750661;22872234;25428506;30084848;30779550;31219806;32222279;33300544;34428180;37828378", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQT4;Q9CYB3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005737 cytoplasm;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D8W5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B9EKX1-1", "uniprot_id": "PTHD4_MOUSE", "mass": 103115.0, "length": 904, "protein_name": "Patched domain-containing protein 4", "gene_name": "Ptchd4", "organism": "Mouse", "refseq_name": "patched domain-containing protein 4 isoform 1", "refseq_ac": "NP_001342199", "gene_names_uniprotkb": "Ptchd4; 3110082D06Rik", "gene_names_refseq": "3110082D06Rik; Gm321; Ptchd4", "protein_names_uniprotkb": "Patched domain-containing protein 4", "protein_names_refseq": "patched domain-containing protein 4 isoform 1; patched domain-containing protein 4; patched domain-containing protein C6orf138 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:627626)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B9EKX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V95-1", "uniprot_id": "PTH2R_MOUSE", "mass": 61908.0, "length": 546, "protein_name": "Parathyroid hormone 2 receptor", "gene_name": "Pth2r", "organism": "Mouse", "refseq_name": "parathyroid hormone 2 receptor precursor", "refseq_ac": "NP_644676", "gene_names_uniprotkb": "Pth2r; Pthr2", "gene_names_refseq": "Pth2r; Pthr2", "protein_names_uniprotkb": "Parathyroid hormone 2 receptor; PTH2 receptor", "protein_names_refseq": "PTH2 receptor; parathyroid hormone 2 receptor precursor; parathyroid hormone receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:213527); (R-MMU-373080); (R-MMU-418555)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11471062;11861531;17394159;21750661;28890271", "class_list": "", "function": "This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity)., [UniProtKB]; This study demonstrated that The parathyroid hormone 2 receptor participates in physiological and behavioral alterations of mother mice., [RefSeq, PubMed]; We propose that TIP39 is an endogenous ligand of the PTH2R and that they form a neuromodulator system, which is optimally positioned to regulate limbic, endocrine, and auditory brain functions., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004991 parathyroid hormone receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91V95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYZ9-1", "uniprot_id": "PRS30_MOUSE", "mass": 33707.0, "length": 310, "protein_name": "Serine protease 30", "gene_name": "Prss30", "organism": "Mouse", "refseq_name": "serine protease 30 precursor", "refseq_ac": "NP_038949", "gene_names_uniprotkb": "Prss30; Disp; Tmprss8", "gene_names_refseq": "2010015P21Rik; Disp1; Disp; Prss30; Tmprss8", "protein_names_uniprotkb": "Serine protease 30; 3.4.21.-; Distal intestinal serine protease; Transmembrane serine protease 8", "protein_names_refseq": "distal intestinal serine protease; protease, serine 30; serine protease 30 precursor; transmembrane protease, serine 8 (intestinal); transmembrane serine protease 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:30943)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10786627;21750661;36288343", "class_list": "", "function": "Selectively cleaves synthetic peptide substrates of trypsin. Activates the epithelial sodium channel ENaC (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91XC4", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017080 sodium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QYZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05142-1", "uniprot_id": "PRH1_MOUSE", "mass": 26090.0, "length": 261, "protein_name": "Proline-rich protein HaeIII subfamily 1", "gene_name": "Prh1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prh1; Prp2; Prp", "gene_names_refseq": "", "protein_names_uniprotkb": "Proline-rich protein HaeIII subfamily 1; Proline-rich protein MP-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:19131)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;2999141;3840480", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q62107", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P05142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z4S3-1", "uniprot_id": "PTRD1_MOUSE", "mass": 16037.0, "length": 140, "protein_name": "Putative peptidyl-tRNA hydrolase PTRHD1", "gene_name": "Ptrhd1", "organism": "Mouse", "refseq_name": "putative peptidyl-tRNA hydrolase PTRHD1", "refseq_ac": "NP_001191841", "gene_names_uniprotkb": "Ptrhd1", "gene_names_refseq": "2410017P09Rik; Ptrhd1", "protein_names_uniprotkb": "Putative peptidyl-tRNA hydrolase PTRHD1; 3.1.1.29; Peptidyl-tRNA hydrolase domain-containing protein 1", "protein_names_refseq": "peptidyl-tRNA hydrolase domain-containing protein 1; putative peptidyl-tRNA hydrolase PTRHD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69709)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a putative peptidyl-tRNA hydrolase, it might be involved in releasing tRNAs from the ribosome during protein synthesis. Some evidence, however, suggests that it lacks peptidyl-tRNA hydrolase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.29", "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z4S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C2E4-1", "uniprot_id": "PTCD1_MOUSE", "mass": 77594.0, "length": 695, "protein_name": "Pentatricopeptide repeat-containing protein 1, mitochondrial", "gene_name": "Ptcd1", "organism": "Mouse", "refseq_name": "pentatricopeptide repeat-containing protein 1, mitochondrial", "refseq_ac": "NP_598496", "gene_names_uniprotkb": "Ptcd1", "gene_names_refseq": "1110069M14Rik; Ptcd1", "protein_names_uniprotkb": "Pentatricopeptide repeat-containing protein 1, mitochondrial", "protein_names_refseq": "pentatricopeptide repeat-containing protein 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:71799)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29617655", "class_list": "", "function": "Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Also affects the 3'-processing of mitochondrial tRNAs., [UniProtKB]; PTCD1 is essential for 16s rRNA maturation complex stability and mitochondrial ribosome assembly., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB29;Q5XK29;Q99KB2", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042780 tRNA 3'-end processing;GO:1900864 mitochondrial RNA modification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C2E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70435-1", "uniprot_id": "PSA3_MOUSE", "mass": 28405.0, "length": 255, "protein_name": "Proteasome subunit alpha type-3", "gene_name": "Psma3", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-3 isoform a", "refseq_ac": "NP_035314", "gene_names_uniprotkb": "Psma3", "gene_names_refseq": "Lmpc8; Psma3", "protein_names_uniprotkb": "Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8; Proteasome subunit K; Proteasome subunit alpha-7; alpha-7", "protein_names_refseq": "alpha-7; macropain subunit C8; multicatalytic endopeptidase complex subunit C8; proteasome (prosome, macropain) subunit, alpha type 3; proteasome component C8; proteasome subunit K; proteasome subunit alpha type-3 isoform a; proteasome subunit alpha type-3; proteasome subunit alpha-7", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:19167); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10436176;16581775;16857966;17242355;18299400;18630941;19131326;19144319;21183079;21750661;21952136;22341445;23806337;25428506;25605945;26070558;26740625;30084848;34428180;35820727;37507081", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2., [UniProtKB, PubMed, PubMed]; Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O70435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810J1-1", "uniprot_id": "PSG22_MOUSE", "mass": 53225.0, "length": 475, "protein_name": "Pregnancy-specific glycoprotein 22", "gene_name": "Psg22", "organism": "Mouse", "refseq_name": "pregnancy-specific glycoprotein 22 precursor", "refseq_ac": "NP_001004152", "gene_names_uniprotkb": "Psg22", "gene_names_refseq": "Psg22; cea9", "protein_names_uniprotkb": "Pregnancy-specific glycoprotein 22", "protein_names_refseq": "carcinoembryonic antigen-related cell adhesion molecule 1 pseudogene; pregnancy-specific glycoprotein 22 precursor; pregnancy-specific glycoprotein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:243862); (R-MMU-163125); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;22423048", "class_list": "", "function": "Expressed early in pregnancy with the ability to induce the secretion of proangiogenic factors in immune cell types, including uterine dendritic and NK cells Publication Status: Online-Only, [RefSeq, PubMed]; May have an angiogenic function during early placental development. Binds to cell-surface heparan sulfate proteoglycans (HSPGs), and stimulates secretion of the proangiogenic factors VEGFA and TGFB from uterine dendritic cells and natural killer cells. Also induces endothelial tube formation in vitro., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q66JZ0", "ec_number_list": "", "go_molecular_function": "GO:0045545 syndecan binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0045766 positive regulation of angiogenesis;GO:0001819 positive regulation of cytokine production;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q810J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14685-1", "uniprot_id": "PSMD3_MOUSE", "mass": 60718.0, "length": 530, "protein_name": "26S proteasome non-ATPase regulatory subunit 3", "gene_name": "Psmd3", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 3", "refseq_ac": "NP_033465", "gene_names_uniprotkb": "Psmd3; P91a; Tstap91a", "gene_names_refseq": "AntP91a; D11Bwg1349e; Psd3; Psmd3; Tstap91a", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; Proteasome subunit p58; Transplantation antigen P91A; Tum-P91A antigen", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; proteasome subunit p58; tissue specific transplantation antigen P91A; tum-P91A antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:22123); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;16479539;16857966;20173027;21183079;21750661;23386199;25428506;25428507;25605945;2568889;26740625;30084848;30779550;31219806;33300544;34428180;35820727;36210013;37453647;37507081;37828378", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP95;Q99LL7", "ec_number_list": "", "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0042176 regulation of protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P14685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28063-1", "uniprot_id": "PSB8_MOUSE", "mass": 30260.0, "length": 276, "protein_name": "Proteasome subunit beta type-8", "gene_name": "Psmb8", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-8", "refseq_ac": "NP_034854", "gene_names_uniprotkb": "Psmb8; Lmp7; Mc13", "gene_names_refseq": "Lmp-7; Lmp7; Psmb8", "protein_names_uniprotkb": "Proteasome subunit beta type-8; 3.4.25.1; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i", "protein_names_refseq": "MC13 (LMP7); large multifunctional protease 7; low molecular mass protein 7; macropain subunit C13; multicatalytic endopeptidase complex subunit C13; proteasome component C13; proteasome subunit MC13; proteasome subunit beta type-8; proteasome subunit beta-5i; proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteosome beta 8 subunit", "tax_id": 10090, "disease": "proteasome-associated autoinflammatory syndrome 1 (Disease Ontology:DOID:0050553); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:16913); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-9907900); (R-MMU-9912633)", "pathway_count": 5, "publication_count": 35, "publication_id_list": "10657640;15371230;15907481;1633842;16452686;16857966;17142736;18250455;18299400;19224205;19525961;20173027;20484733;21750661;21881205;21952136;22341445;22645316;22872234;23706739;24788674;25428506;25605945;26495903;28011936;30084848;31219806;34428180;35820727;36210013;37453647;8066463;8344725;8406612;8854085", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the inflammatory response pathway. Required for adipocyte differentiation (PubMed:21881205, PubMed:22341445, PubMed:8066463). May be involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UK42;Q64300;Q792S8;Q7TMX9;Q91VH7", "ec_number_list": "3.4.25.1", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045444 fat cell differentiation;GO:0019882 antigen processing and presentation;GO:0051603 proteolysis involved in protein catabolic process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P28063-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09114-1", "uniprot_id": "PTGDS_MOUSE", "mass": 21066.0, "length": 189, "protein_name": "Prostaglandin-H2 D-isomerase", "gene_name": "Ptgds", "organism": "Mouse", "refseq_name": "prostaglandin-H2 D-isomerase precursor", "refseq_ac": "NP_032989", "gene_names_uniprotkb": "Ptgds", "gene_names_refseq": "21kDa; L-PGDS; PGD2; PGDS2; PGDS; Ptgds; Ptgs3", "protein_names_uniprotkb": "Prostaglandin-H2 D-isomerase; 5.3.99.2; Glutathione-independent PGD synthase; L-PGDS; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS2; Prostaglandin-D2 synthase", "protein_names_refseq": "PGD2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin-D synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin-D2 synthase; prostaglandin-H2 D-isomerase precursor; prostaglandin-H2 D-isomerase", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); nephrosclerosis (Disease Ontology:DOID:11664); carotid artery disease (Disease Ontology:DOID:3407); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19215); (R-MMU-2162123)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10781097;10899920;11105911;11751991;12077186;17715133;19546224;19833210;23624557;26192747;26495903;30899004;39173086;8922532;9892701", "class_list": "", "function": "Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:10781097, PubMed:11751991, PubMed:12077186, PubMed:17715133, PubMed:19546224, PubMed:19833210, PubMed:8922532, PubMed:9892701). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Endogenous PGD2 acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O09157;O35091;Q3V2G5;Q62169", "ec_number_list": "5.3.99.2;2.5.1.18", "go_molecular_function": "GO:0004667 prostaglandin-D synthase activity;GO:0005504 fatty acid binding;GO:0005501 retinoid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:2000255 negative regulation of male germ cell proliferation;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0051384 response to glucocorticoid;GO:0019371 cyclooxygenase pathway;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "O09114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35074-1", "uniprot_id": "PTGIS_MOUSE", "mass": 57047.0, "length": 501, "protein_name": "Prostacyclin synthase", "gene_name": "Ptgis", "organism": "Mouse", "refseq_name": "prostacyclin synthase isoform a", "refseq_ac": "NP_032994", "gene_names_uniprotkb": "Ptgis; Cyp8", "gene_names_refseq": "Cyp8a1; Cyp8; Pgis; Ptgis", "protein_names_uniprotkb": "Prostacyclin synthase; 4.2.1.152; 5.3.99.4; Hydroperoxy icosatetraenoate dehydratase; Prostaglandin I2 synthase", "protein_names_refseq": "hydroperoxy icosatetraenoate dehydratase; prostacyclin synthase isoform a; prostacyclin synthase", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); colorectal adenoma (Disease Ontology:DOID:0050860); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); cerebral cavernous malformation 1 (Disease Ontology:DOID:0080491); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); carotid stenosis (Disease Ontology:DOID:13001); patent ductus arteriosus (Disease Ontology:DOID:13832); Parkinson's disease (Disease Ontology:DOID:14330); primary pulmonary hypertension (Disease Ontology:DOID:14557); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19223); (R-MMU-211979); (R-MMU-2162123)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11782360;25428506;34428180;37796199;37828378;39082135;9202154", "class_list": "", "function": "Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer., [RefSeq, PubMed]; Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE)., [UniProtKB, UniProtKB]; Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth., [RefSeq, PubMed]; Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA2 Prostanoids/TP Axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.99.4;4.2.1.152;1.14.14.139;1.14.14.1;5.3.99.5;1.14.99.1;1.14.14.-;5.4.4.7", "go_molecular_function": "GO:0008116 prostaglandin-I synthase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0001666 response to hypoxia;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35074-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55082-1", "uniprot_id": "PTN20_MOUSE", "mass": 49119.0, "length": 426, "protein_name": "Tyrosine-protein phosphatase non-receptor type 20", "gene_name": "Ptpn20", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 20", "refseq_ac": "NP_033004", "gene_names_uniprotkb": "Ptpn20; Typ", "gene_names_refseq": "Ptpn20; typ", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 20; 3.1.3.48; Testis-specific tyrosine phosphatase", "protein_names_refseq": "testis-specific tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:19256)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;35658898;9407093", "class_list": "", "function": "Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4QPF6", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O55082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55234-1", "uniprot_id": "PSB5_MOUSE", "mass": 28532.0, "length": 264, "protein_name": "Proteasome subunit beta type-5", "gene_name": "Psmb5", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-5", "refseq_ac": "NP_035316", "gene_names_uniprotkb": "Psmb5", "gene_names_refseq": "Psmb5", "protein_names_uniprotkb": "Proteasome subunit beta type-5; 3.4.25.1; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit X; Proteasome subunit beta-5; beta-5", "protein_names_refseq": "beta-5; macropain epsilon chain; multicatalytic endopeptidase complex epsilon chain; proteasome beta type subunit 5; proteasome chain 6; proteasome epsilon chain; proteasome subunit X; proteasome subunit beta type-5; proteasome subunit beta-5", "tax_id": 10090, "disease": "proteasome-associated autoinflammatory syndrome 1 (Disease Ontology:DOID:0050553); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:19173); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 18, "publication_id_list": "10436176;14612418;16434403;16581775;16723119;16857966;17521679;18349697;19183883;22341445;25428506;26116868;27768902;28011936;31219806;34428180;37453647;9382924", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity., [UniProtKB, PubMed, PubMed, PubMed]; The P2Y2R enhances Ubiquitin-Proteasome System activity by increasing the subunits expression beta 5 and beta 1., [RefSeq, PubMed]; The role of the ubiquitin-proteasome system in pressure overloaded hearts andheart failure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZI1;Q91X53;Q9CWR4;Q9R1P2", "ec_number_list": "2.3.2.26;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.3.2.27;3.4.19.12;3.4.25.1;2.7.11.1;4.1.1.17;2.7.11.22;2.7.11.23;5.6.1.6;2.3.2.24;2.3.2.23;3.6.5.2;2.3.2.32;3.1.-.-;2.7.11.21;2.4.2.-;2.4.2.30;2.7.11.24;1.14.11.-;1.14.11.29;2.7.11.25;2.7.11.26", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008233 peptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O55234-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05143-1", "uniprot_id": "PRP2_MOUSE", "mass": 31719.0, "length": 317, "protein_name": "Proline-rich protein 2", "gene_name": "Prp2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prp2; Prh1; Prp", "gene_names_refseq": "", "protein_names_uniprotkb": "Proline-rich protein 2; Proline-rich protein MP-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:83380)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;2839509;2999141;3840480", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 1, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q62103;Q62106", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05143-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6B2-1", "uniprot_id": "PTCRA_MOUSE", "mass": 21491.0, "length": 199, "protein_name": "Pre T-cell antigen receptor alpha", "gene_name": "Ptcra", "organism": "Mouse", "refseq_name": "pre T-cell antigen receptor alpha precursor", "refseq_ac": "NP_035325", "gene_names_uniprotkb": "Ptcra", "gene_names_refseq": "Ptcra; gp33; pT-alpha-TCR; pT-alpha; pT[a]; pTalpha; pTa", "protein_names_uniprotkb": "Pre T-cell antigen receptor alpha; gp33; pT-alpha-TCR; pT-alpha; pTa", "protein_names_refseq": "pre T-cell antigen receptor alpha precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:19208)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;7596413;7672822;7973703;9647201", "class_list": "", "function": "Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that plays a crucial role in early T-cell development, particularly alpha-beta T cell differentiation (PubMed:9647201, PubMed:7596413). Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0070244 negative regulation of thymocyte apoptotic process;GO:0046632 alpha-beta T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C6B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DJF2-1", "uniprot_id": "PT117_MOUSE", "mass": 9124.0, "length": 80, "protein_name": "Protein PET117 homolog, mitochondrial", "gene_name": "Pet117", "organism": "Mouse", "refseq_name": "protein PET117 homolog, mitochondrial precursor", "refseq_ac": "NP_001158285", "gene_names_uniprotkb": "Pet117; Gm20571", "gene_names_refseq": "Gm20571; Pet117", "protein_names_uniprotkb": "Protein PET117 homolog, mitochondrial", "protein_names_refseq": "Protein PET117 homolog, mitochondrial; protein PET117 homolog, mitochondrial precursor", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 19 (Disease Ontology:DOID:0070504)", "pathway": " (mmu:100048644)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0DJF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22858-1", "uniprot_id": "PTHR_MOUSE", "mass": 20100.0, "length": 175, "protein_name": "Parathyroid hormone-related protein", "gene_name": "Pthlh", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pthlh; Pthrp", "gene_names_refseq": "", "protein_names_uniprotkb": "Parathyroid hormone-related protein; PLP; PTH-rP; PTHrP; Parathyroid hormone-like protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); brachydactyly type E2 (Disease Ontology:DOID:0110976); achondroplasia (Disease Ontology:DOID:4480)", "pathway": " (R-MMU-373080); (R-MMU-418555)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17301089;20501677;2249778;8314082;8895385", "class_list": "", "function": "Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed:8314082, PubMed:8895385). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (By similarity). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (PubMed:20501677, PubMed:8314082, PubMed:8895385). Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (By similarity). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion (PubMed:17301089). BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (PubMed:17301089)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Potent inhibitor of osteoclastic bone resorption., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0060649 mammary gland bud elongation;GO:0060659 nipple sheath formation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P22858-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32848-1", "uniprot_id": "PRVA_MOUSE", "mass": 11931.0, "length": 110, "protein_name": "Parvalbumin alpha", "gene_name": "Pvalb", "organism": "Mouse", "refseq_name": "parvalbumin alpha", "refseq_ac": "NP_001317615", "gene_names_uniprotkb": "Pvalb; Pva", "gene_names_refseq": "PV; Parv; Pvalb; Pva", "protein_names_uniprotkb": "Parvalbumin alpha; Alpha-PV; Alpha-parvalbumin", "protein_names_refseq": "alpha-PV; alpha-parvalbumin; parvalbumin alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:19293)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10036163;17977745;2572511;39927985;7522680;7818852", "class_list": "", "function": "In muscle, parvalbumin is thought to be involved in relaxation after contraction (By similarity). It binds two calcium ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0098976 excitatory chemical synaptic transmission;GO:0010467 gene expression;GO:0098977 inhibitory chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32848-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49446-1", "uniprot_id": "PTPRE_MOUSE", "mass": 80688.0, "length": 699, "protein_name": "Receptor-type tyrosine-protein phosphatase epsilon", "gene_name": "Ptpre", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase epsilon isoform a precursor", "refseq_ac": "NP_001303607", "gene_names_uniprotkb": "Ptpre; Ptpe", "gene_names_refseq": "PTPepsilon; PTPe; Ptpre; RPTPepsilon", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase epsilon; 3.1.3.48; Protein-tyrosine phosphatase epsilon; R-PTP-epsilon", "protein_names_refseq": "R-PTP-epsilon; protein-tyrosine phosphatase epsilon; receptor-type tyrosine-protein phosphatase epsilon isoform a precursor; receptor-type tyrosine-protein phosphatase epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:19267)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10980613;12861030;1454056;17947660;18006633;18231724;18924107;19144319;1932742;19508371;21750661;24694598;25381250;26740625;27802388;31844669;34428180;7592814;7832766;8610169;8618876;9914474", "class_list": "", "function": "Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver (By similarity). Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function., [UniProtKB, PubMed, PubMed]; Acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake., [UniProtKB]; GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in osteoclast-like cells., [RefSeq, PubMed]; Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PTPs alpha and epsilon play distinct roles in osteoclasts., [RefSeq, PubMed]; We describe a new regulatory mechanism, where an unreported lncRNA, PTPRE-AS1, targets receptor-type tyrosine protein phosphatase epsilon (PTPRE) to regulate macrophage activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U369;Q60986;Q61042;Q62134;Q62444;Q64496", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007185 cell surface receptor protein tyrosine phosphatase signaling pathway;GO:0007165 signal transduction;GO:0033003 regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P49446-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50405-1", "uniprot_id": "PSPB_MOUSE", "mass": 41728.0, "length": 377, "protein_name": "Pulmonary surfactant-associated protein B", "gene_name": "Sftpb", "organism": "Mouse", "refseq_name": "pulmonary surfactant-associated protein B isoform 1 precursor", "refseq_ac": "NP_680088", "gene_names_uniprotkb": "Sftpb; Sftp3", "gene_names_refseq": "SF-B; SP-B; Sftp-3; Sftp3; Sftpb", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteolipid SPL(Phe); SP-B", "protein_names_refseq": "pulmonary surfactant-associated protein B isoform 1 precursor; pulmonary surfactant-associated protein B; pulmonary surfactant-associated proteolipid SPL(Phe)", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); lung cancer (Disease Ontology:DOID:1324); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20388); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;7900819", "class_list": "glycogene", "function": "Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005764 lysosome", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50405-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54830-1", "uniprot_id": "PTN5_MOUSE", "mass": 60815.0, "length": 541, "protein_name": "Tyrosine-protein phosphatase non-receptor type 5", "gene_name": "Ptpn5", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 5", "refseq_ac": "NP_001157037", "gene_names_uniprotkb": "Ptpn5", "gene_names_refseq": "Ptpn5; Step", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 5; 3.1.3.48; Neural-specific protein-tyrosine phosphatase; STEP; Striatum-enriched protein-tyrosine phosphatase", "protein_names_refseq": "neural-specific protein-tyrosine phosphatase; striatum-enriched protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 5", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:19259)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "30059200;33300544;34290083;36639708;36971428;7494467;8987810", "class_list": "", "function": "May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors., [UniProtKB]; Mechanisms of mGluR-dependent plasticity in hippocampal area CA2., [RefSeq, PubMed]; Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner., [RefSeq, PubMed]; Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64694;Q8CAN0", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0001934 positive regulation of protein phosphorylation;GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P54830-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70195-1", "uniprot_id": "PSB7_MOUSE", "mass": 29891.0, "length": 277, "protein_name": "Proteasome subunit beta type-7", "gene_name": "Psmb7", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-7 precursor", "refseq_ac": "NP_035317", "gene_names_uniprotkb": "Psmb7; Mmc14", "gene_names_refseq": "MC14; Psmb7", "protein_names_uniprotkb": "Proteasome subunit beta type-7; 3.4.25.1; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit Z; Proteasome subunit beta-2; beta-2", "protein_names_refseq": "beta-2; macropain chain Z; multicatalytic endopeptidase complex chain Z; proteasome subunit Z; proteasome subunit beta type-7 precursor; proteasome subunit beta type-7; proteasome subunit beta-2", "tax_id": 10090, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010)", "pathway": " (mmu:19177); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 59, "publication_count": 13, "publication_id_list": "16581775;16857966;17521679;21455682;22341445;25428506;25605945;26495903;32069316;34428180;37828378;8799160;9300697", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity., [UniProtKB, PubMed, PubMed]; Data demonstrate that TNF-alpha expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5, PSMB6, PSMB7) of the proteasome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09084;Q542F7;Q9CZH4;Q9DCF7", "ec_number_list": "2.3.2.26;2.4.1.25;3.2.1.33;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.5.4.6;1.11.1.24;2.3.2.27;3.4.22.52;3.4.19.12;3.4.25.1;2.7.11.1;3.4.22.27;1.1.1.42;4.1.1.17;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;2.7.11.22;2.7.11.23;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.6.1.6;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.1.40;2.3.2.24;2.3.2.23;3.5.4.5;3.6.5.2;2.3.2.32;2.7.11.39;3.1.-.-;2.7.4.6;2.7.13.3;3.6.4.6;2.7.11.21;2.7.1.1;2.7.1.-;2.4.2.-;2.4.2.30;3.1.1.47;3.6.4.13;5.4.2.2;5.4.2.7;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;1.14.11.-;1.14.11.29;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;2.7.11.25;3.4.18.1;3.5.1.23;3.5.1.-;2.7.11.26", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70195-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70289-1", "uniprot_id": "PTPRV_MOUSE", "mass": 186796.0, "length": 1705, "protein_name": "Receptor-type tyrosine-protein phosphatase V", "gene_name": "Ptprv", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ptprv; Esp", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase V; 3.1.3.48; ES cell phosphatase; Embryonic stem cell protein-tyrosine phosphatase; R-PTP-V", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17693256;20655470;25428506;31599954;8951793", "class_list": "", "function": "Protein tyrosine phosphatase that acts as a regulator of energy metabolism by mediating dephosphorylation of insulin receptor (Insr) (PubMed:17693256, PubMed:20655470). Prevents decarboxylation of osteocalcin (Bglap and Bglap2) via an indirect mechanism: dephosphorylation of insulin receptor prevents insulin signaling-dependent decarboxylation of osteocalcin, preventing the hormone activity of osteocalcin (PubMed:17693256, PubMed:20655470). May play a role in the maintenance of pluripotency (PubMed:8951793)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 18, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0018214 protein carboxylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70289-1", "record_type": "protein" } ]