[ { "uniprot_canonical_ac": "O88890-1", "uniprot_id": "SH21A_MOUSE", "mass": 13904.0, "length": 126, "protein_name": "SH2 domain-containing protein 1A", "gene_name": "Sh2d1a", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 1A isoform 1", "refseq_ac": "NP_001300617", "gene_names_uniprotkb": "Sh2d1a; Xlp", "gene_names_refseq": "Gm686; SAP; Sh2d1a", "protein_names_uniprotkb": "SH2 domain-containing protein 1A; SLAM-associated protein; Signaling lymphocytic activation molecule-associated protein; T-cell signal transduction molecule SAP", "protein_names_refseq": "Duncan disease homolog; SH2 domain protein 1A; SH2 domain-containing protein 1A isoform 1; SH2 domain-containing protein 1A; T-cell signal transduction molecule SAP; signaling lymphocytic activation molecule-associated protein", "tax_id": 10090, "disease": "X-linked lymphoproliferative syndrome 1 (Disease Ontology:DOID:0060705)", "pathway": " (mmu:20400)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10970095;12545173;16223723;19648922;20962259;21219180;21750661;22683124;38766687;9774102", "class_list": "", "function": "Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions (PubMed:22683124). Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation (PubMed:19648922). In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (PubMed:22683124). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; SAP deletion promotes malignant insulinoma progression by inducing CXCL12 secretion from CAFs via the CXCR4/p38/ERK signalling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANL8;Q9QWV6", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0045087 innate immune response;GO:0006968 cellular defense response;GO:0050776 regulation of immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD37-1", "uniprot_id": "SGIP1_MOUSE", "mass": 86063.0, "length": 806, "protein_name": "SH3-containing GRB2-like protein 3-interacting protein 1", "gene_name": "Sgip1", "organism": "Mouse", "refseq_name": "SH3-containing GRB2-like protein 3-interacting protein 1 isoform c", "refseq_ac": "NP_001272788", "gene_names_uniprotkb": "Sgip1", "gene_names_refseq": "3110007P09Rik; SGIP1alpha; Sgip1; gag", "protein_names_uniprotkb": "SH3-containing GRB2-like protein 3-interacting protein 1; Endophilin-3-interacting protein", "protein_names_refseq": "SH3-containing GRB2-like protein 3-interacting protein 1 isoform c; SH3-containing GRB2-like protein 3-interacting protein 1; SH3-domain GRB2-like interacting protein 1 alpha; endophilin-3-interacting protein", "tax_id": 10090, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894)", "pathway": " (mmu:73094)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15345747;15919751;16452087;17626015;21183079;21747946;21750661;22826440;30084848;32848054;34428180;34678516;35820727;35822049;37783296;40885482", "class_list": "", "function": "May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization., [RefSeq, PubMed]; SGIP1 is an important and novel member of the group of neuronal molecules required for the regulation of energy homeostasis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A7BFW0;Q3UFU3;Q3UGA0;Q8BXX4;Q8C034;Q9CXT2", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0017124 SH3 domain binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle;GO:0030122 AP-2 adaptor complex", "go_biological_process": "GO:1904000 positive regulation of eating behavior;GO:0097009 energy homeostasis;GO:2000253 positive regulation of feeding behavior;GO:0072583 clathrin-dependent endocytosis;GO:0048260 positive regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8VD37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W00-1", "uniprot_id": "PP1RA_MOUSE", "mass": 94372.0, "length": 888, "protein_name": "Serine/threonine-protein phosphatase 1 regulatory subunit 10", "gene_name": "Ppp1r10", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 1 regulatory subunit 10", "refseq_ac": "NP_001157290", "gene_names_uniprotkb": "Ppp1r10; Cat53; Pnuts", "gene_names_refseq": "2610025H06Rik; Cat53; D17Ertd808e; Fb19; Pnuts; Ppp1r10", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 1 regulatory subunit 10; MHC class I region proline-rich protein CAT53; Phosphatase 1 nuclear targeting subunit", "protein_names_refseq": "HLA-C adjacent transcript 53; MHC class I region proline-rich protein CAT53; phosphatase 1 nuclear targeting subunit; protein phosphatase I; serine/threonine-protein phosphatase 1 regulatory subunit 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:52040)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;18325784;20372802;20516061;21750661;24129315;31219806;34428180;35820727;38714838", "class_list": "", "function": "Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase 1 (PP1) and GABA(C) receptors simultaneously bind to different domains of PNUTS, demonstrating that PNUTS crosslinks PP1 and GABA(C) receptors., [RefSeq, PubMed]; Stimulation of PP1 activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells, [RefSeq, PubMed]; Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (By similarity). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (By similarity). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (By similarity). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (By similarity). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (By similarity). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex. In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex. In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1B179;Q811B6;Q8C6T7;Q8K2U8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0072357 PTW/PP1 phosphatase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0050821 protein stabilization;GO:0006366 transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0010667 negative regulation of cardiac muscle cell apoptotic process;GO:2000806 positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80W00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKY5-1", "uniprot_id": "HIP1R_MOUSE", "mass": 119426.0, "length": 1068, "protein_name": "Huntingtin-interacting protein 1-related protein", "gene_name": "Hip1r", "organism": "Mouse", "refseq_name": "huntingtin-interacting protein 1-related protein", "refseq_ac": "NP_659507", "gene_names_uniprotkb": "Hip1r", "gene_names_refseq": "Hip1r; mKIAA0655", "protein_names_uniprotkb": "Huntingtin-interacting protein 1-related protein; HIP1-related protein", "protein_names_refseq": "HIP1-related protein; huntingtin-interacting protein 1-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:29816); (R-MMU-432722); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10613908;17452370;18790740;21750661;30084848;34428180;39627609", "class_list": "", "function": "Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJ14", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0060453 regulation of gastric acid secretion;GO:1905445 positive regulation of clathrin coat assembly;GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0006897 endocytosis;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JKY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKX6-1", "uniprot_id": "SMG1_MOUSE", "mass": 409769.0, "length": 3658, "protein_name": "Serine/threonine-protein kinase SMG1", "gene_name": "Smg1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase SMG1", "refseq_ac": "NP_001026984", "gene_names_uniprotkb": "Smg1; Atx; Kiaa0421; Lip", "gene_names_refseq": "2610207I05Rik; 5430435M13Rik; C130002K18Rik; Smg1; mKIAA0421", "protein_names_uniprotkb": "Serine/threonine-protein kinase SMG1; 2.7.11.1; Lambda-interacting protein; Lambda/iota protein kinase C-interacting protein; Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1; SMG-1", "protein_names_refseq": "PI-3-kinase-related kinase SMG-1; SMG1 homolog, phosphatidylinositol 3-kinase-related kinase; lambda-interacting protein; lambda/iota protein kinase C-interacting protein; nonsense mediated mRNA decay-associated PI3K-related kinase SMG1; phosphatidylinositol 3-kinase-related protein kinase; serine/threonine-protein kinase SMG1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233789); (R-MMU-975957)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;17242355;20566848;20864032;21183079;21750661;23806337;25428506;26495903;30084848;30779550;31219806;32665638;32782141;34428180;36400430", "class_list": "", "function": "Results demonstrate a critical role for Smg1 in early mouse development and link the loss of this NMD factor to major and widespread changes in the mammalian transcriptome., [RefSeq, PubMed]; SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma., [RefSeq, PubMed]; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ (By similarity)., [UniProtKB]; The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QLR6;Q5DU42;Q6ZQC0;Q8BLU4;Q8BWJ5;Q8BXD3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.1.-.-;4.2.99.18;3.1.3.16;2.7.11.39;2.3.1.-;3.6.5.-;2.7.11.31;2.3.1.48;4.1.1.32;2.7.11.38;3.6.4.13;3.6.1.62;3.6.1.-;3.6.-.-;5.6.2.3;5.6.2.5;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0042162 telomeric DNA binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0033391 chromatoid body", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0046777 protein autophosphorylation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8BKX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54957-1", "uniprot_id": "LAT_MOUSE", "mass": 26015.0, "length": 242, "protein_name": "Linker for activation of T-cells family member 1", "gene_name": "Lat", "organism": "Mouse", "refseq_name": "linker for activation of T-cells family member 1", "refseq_ac": "NP_034819", "gene_names_uniprotkb": "Lat", "gene_names_refseq": "Lat; p36-38; pp36", "protein_names_uniprotkb": "Linker for activation of T-cells family member 1; 36 kDa phosphotyrosine adapter protein; p36-38; pp36", "protein_names_refseq": "36 kDa phospho-tyrosine adapter protein; 36 kDa phosphotyrosine adapter protein; linker for activation of T-cells family member 1; linker protein", "tax_id": 10090, "disease": "IgG4-related disease (Disease Ontology:DOID:0080356); immunodeficiency 52 (Disease Ontology:DOID:0111983)", "pathway": " (mmu:16797); (R-MMU-114604); (R-MMU-202433); (R-MMU-2424491); (R-MMU-2454202); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-5673001)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "10843385;11463797;12626544;14696041;19592663;21183079;21750661;22561606;22732588;30779550;34428180;9489702", "class_list": "", "function": "Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0035591 signaling adaptor activity;GO:0030159 signaling receptor complex adaptor activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O54957-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z198-1", "uniprot_id": "NL1B2_MOUSE", "mass": 134163.0, "length": 1177, "protein_name": "NACHT, LRR and PYD domains-containing protein 1b allele 2", "gene_name": "Nlrp1b", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform 1", "refseq_ac": "NP_001035786", "gene_names_uniprotkb": "Nlrp1b; Nalp1b", "gene_names_refseq": "Nalp1b; Nlrp1b", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 1b allele 2; 3.4.-.-", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform 1; NACHT, LRR and PYD domains-containing protein 1b; NACHT-, LRR-, and PYD-containing protein 1 paralog b", "tax_id": 10090, "disease": "vitiligo (Disease Ontology:DOID:12306)", "pathway": " (mmu:637515)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16429160;18511561;19651869;19949100;21170303;23506131;24218483;24492532;26253422;31383852;32558991;34428180;35784371", "class_list": "", "function": "Acts as the sensor component of the Nlrp1b inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (By similarity). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (By similarity). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals: in response to pathogen-associated signals, the N-terminal part of Nlrp1b is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1b, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (By similarity). In the absence of GSDMD expression, the Nlrp1b inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (By similarity). Activation of Nlrp1b inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (By similarity). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; An extremely polymorphic gene in this locus, Nalp1b, is the primary mediator of mouse macrophage susceptibility to LeTx (lethal toxin), [RefSeq, PubMed]; Animals expressing a lethal toxin (LT)-sensitive allele of Nlrp1b showed an early inflammatory response to LT and increased resistance to infection by B. anthracis, [RefSeq, PubMed]; Constitutes the active part of the Nlrp1b inflammasome. In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of Nlrp1b (NACHT, LRR and PYD domains-containing protein 1b, N-terminus), preventing activation of the Nlrp1b inflammasome. In response to pathogen-associated signals, the N-terminal part of Nlrp1b is degraded by the proteasome, releasing this form, which polymerizes to form the Nlrp1b inflammasome complex: the Nlrp1b inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis., [UniProtKB, UniProtKB]; Constitutes the precursor of the Nlrp1b inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals., [UniProtKB, UniProtKB]; Data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1b(S), caspase-1, and IL-1beta in countering anthrax infection. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory part that prevents formation of the Nlrp1b inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1b (NACHT, LRR and PYD domains-containing protein 1b, C-terminus), preventing activation of the Nlrp1b inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1b inflammasome., [UniProtKB, UniProtKB]; The authors demonstrate that transfection of human fibroblasts with plasmids encoding murine Nlrp1b and procaspase-1 was sufficient to confer susceptibility to lethal toxin-mediated death on the cells., [RefSeq, PubMed]; UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1beta Antibody. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6R9S5;Q2LK61;Q2LKV8", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0072558 NLRP1 inflammasome complex", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0002221 pattern recognition receptor signaling pathway;GO:1904784 NLRP1 inflammasome complex assembly;GO:0006954 inflammatory response;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A1Z198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA75-1", "uniprot_id": "NLS1_MOUSE", "mass": 58984.0, "length": 534, "protein_name": "Sodium-dependent lysophosphatidylcholine symporter 1", "gene_name": "Mfsd2a", "organism": "Mouse", "refseq_name": "sodium-dependent lysophosphatidylcholine symporter 1", "refseq_ac": "NP_083938", "gene_names_uniprotkb": "Mfsd2a; Mfsd2; Nls1", "gene_names_refseq": "1700018O18Rik; Mfsd2a; Mfsd2; NLS1", "protein_names_uniprotkb": "Sodium-dependent lysophosphatidylcholine symporter 1; Major facilitator superfamily domain-containing protein 2A; Mfsd2a; NLS1; Sodium-dependent LPC symporter 1", "protein_names_refseq": "major facilitator superfamily domain containing 2A; major facilitator superfamily domain containing 2; major facilitator superfamily domain-containing protein 2A; sodium-dependent LPC symporter 1; sodium-dependent lysophosphatidylcholine symporter 1", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 15 (Disease Ontology:DOID:0070277); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:76574); (R-MMU-1483191)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;18694395;21750661;23209793;24828040;24828044;25428506;26005868;34349262;38852535", "class_list": "", "function": "Data suggest that the ligand(s) that are transported by MFSD2A play important roles in these physiological processes and await future identification., [RefSeq, PubMed]; Mfsd2a regulates the blood-labyrinth-barrier formation and function through tight junctions and transcytosis., [RefSeq, PubMed]; Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis., [RefSeq, PubMed]; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:18694395, PubMed:23209793, PubMed:24828040, PubMed:24828044, PubMed:34349262). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (PubMed:24828040, PubMed:24828044, PubMed:34349262). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:24828040, PubMed:24828044, PubMed:34349262). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (PubMed:24828044, PubMed:34349262). Does not transport docosahexaenoic acid in unesterified fatty acid (PubMed:24828044). Not required for central nervous system vascular morphogenesis (PubMed:24828040)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 40, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZW8", "ec_number_list": "", "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0051978 lysophospholipid:sodium symporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0015293 symporter activity;GO:0140348 lysophosphatidylcholine flippase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0051977 lysophospholipid transport;GO:1990379 lipid transport across blood-brain barrier;GO:0060856 establishment of blood-brain barrier;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DA75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54949-1", "uniprot_id": "NLK_MOUSE", "mass": 58313.0, "length": 527, "protein_name": "Serine/threonine-protein kinase NLK", "gene_name": "Nlk", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase NLK", "refseq_ac": "NP_032728", "gene_names_uniprotkb": "Nlk", "gene_names_refseq": "Nlk", "protein_names_uniprotkb": "Serine/threonine-protein kinase NLK; 2.7.11.24; Nemo-like kinase", "protein_names_refseq": "serine/threonine-protein kinase NLK", "tax_id": 10090, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:18099); (R-MMU-4086398)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10.3389/fragi.2021.757801;10391247;11745377;12482967;12556497;14720327;15004007;15082531;15308626;16055500;17114649;17785444;18765672;20118921;20194509;20874444;21118996;21183079;21750661;31219806;32620751;35822049;37384409;9448268", "class_list": "", "function": "Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. Publication Status: Online-Only, [RefSeq, PubMed]; Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:10391247, PubMed:11745377, PubMed:12482967, PubMed:12556497, PubMed:14720327, PubMed:15004007, PubMed:17785444, PubMed:18765672, PubMed:20874444, PubMed:21118996, PubMed:9448268). Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 (PubMed:15004007). Negative regulator of the canonical Wnt/beta-catenin signaling pathway (PubMed:20194509). Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 (PubMed:12556497). Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes (PubMed:12556497). Negative regulator of the Notch signaling pathway (PubMed:20118921). Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 (PubMed:20118921). Negative regulator of the MYB family of transcription factors (PubMed:16055500). Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP (PubMed:15082531, PubMed:15308626, PubMed:16055500). Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself (PubMed:15082531, PubMed:15308626, PubMed:16055500). Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (PubMed:15004007). Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members (By similarity). Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (By similarity). Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SYE6;Q6PF98", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O54949-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0J0-1", "uniprot_id": "NPC2_MOUSE", "mass": 16442.0, "length": 149, "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "Npc2", "organism": "Mouse", "refseq_name": "NPC intracellular cholesterol transporter 2 precursor", "refseq_ac": "NP_075898", "gene_names_uniprotkb": "Npc2", "gene_names_refseq": "2700012J19Rik; HE1; Npc2", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 2; Epididymal secretory protein E1; Niemann Pick type C2 protein homolog; mE1", "protein_names_refseq": "NPC intracellular cholesterol transporter 2 precursor; Niemann-Pick type C2; epididymal secretory protein E1; mE1; niemann Pick type C2 protein homolog", "tax_id": 10090, "disease": "Niemann-Pick disease type C2 (Disease Ontology:DOID:0070114); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (mmu:67963); (R-MMU-6798695); (R-MMU-8964038)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10863096;12591949;17018531;19232397;21315718;21412152;23806337;26296895;34428180;34857757", "class_list": "", "function": "Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors. Publication Status: Online-Only, [RefSeq, PubMed]; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:12591949, PubMed:17018531, PubMed:21315718, PubMed:26296895). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (PubMed:21315718)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; NPC2 protein has binding sites with a role in efficient secretion, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB23", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005770 late endosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0008203 cholesterol metabolic process;GO:0009615 response to virus;GO:0032367 intracellular cholesterol transport;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z0J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P7W2-1", "uniprot_id": "SHKB1_MOUSE", "mass": 76103.0, "length": 704, "protein_name": "SH3KBP1-binding protein 1", "gene_name": "Shkbp1", "organism": "Mouse", "refseq_name": "SH3KBP1-binding protein 1", "refseq_ac": "NP_619617", "gene_names_uniprotkb": "Shkbp1; Sb1", "gene_names_refseq": "B930062H15Rik; Sb1; Shkbp1", "protein_names_uniprotkb": "SH3KBP1-binding protein 1; SETA-binding protein 1", "protein_names_refseq": "SETA binding protein 1; SH3KBP1-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:192192)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11152963;21830225;30084848;31219806;34112919;37343421", "class_list": "", "function": "CD8 + T-cell number and function are altered by Shkbp1 knockout mediated suppression of tumor growth in mice., [RefSeq, PubMed]; Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation (PubMed:21830225)., [UniProtKB, PubMed]; Suppression of tumor growth and metastasis in Shkbp1 knockout mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUN8;Q9ES31", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P7W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2Q9-1", "uniprot_id": "SHOT1_MOUSE", "mass": 71343.0, "length": 631, "protein_name": "Shootin-1", "gene_name": "Shtn1", "organism": "Mouse", "refseq_name": "shootin-1 isoform 1", "refseq_ac": "NP_001107784", "gene_names_uniprotkb": "Shtn1; Kiaa1598", "gene_names_refseq": "4930506M07Rik; Shootin1; Shtn1; mKIAA1598", "protein_names_uniprotkb": "Shootin-1; Shootin1", "protein_names_refseq": "shootin-1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71653)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17030985;17242355;19403918;21183079;23864681;34428180;37044214", "class_list": "", "function": "Dephosphorylation of neural wiring protein shootin1 by PP1 phosphatase regulates netrin-1-induced axon guidance., [RefSeq, PubMed]; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:23864681). Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth (By similarity). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681). Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (PubMed:23864681)., [UniProtKB, UniProtKB, PubMed]; Our data demonstrate the importance of the Shootin1/KIF20B interaction to the dynamic process of pyramidal neuronal polarization and migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTW5;Q8C4F6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0050839 cell adhesion molecule binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030027 lamellipodium;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0061163 endoplasmic reticulum polarization;GO:0061573 actin filament bundle retrograde transport;GO:0007409 axonogenesis;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K2Q9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97801-1", "uniprot_id": "SMN_MOUSE", "mass": 31254.0, "length": 288, "protein_name": "Survival motor neuron protein", "gene_name": "Smn1", "organism": "Mouse", "refseq_name": "survival motor neuron protein isoform 2", "refseq_ac": "NP_001239558", "gene_names_uniprotkb": "Smn1; Smn", "gene_names_refseq": "Gemin1; Smn1; Smn", "protein_names_uniprotkb": "Survival motor neuron protein", "protein_names_refseq": "survival motor neuron protein isoform 2; survival motor neuron protein; survival of motor neuron protein", "tax_id": 10090, "disease": "adult spinal muscular atrophy (Disease Ontology:DOID:0050529); intermediate spinal muscular atrophy (Disease Ontology:DOID:0050530); childhood spinal muscular atrophy (Disease Ontology:DOID:0060160); juvenile spinal muscular atrophy (Disease Ontology:DOID:12376); spinal muscular atrophy (Disease Ontology:DOID:12377); Werdnig-Hoffmann disease (Disease Ontology:DOID:13137)", "pathway": " (mmu:20595); (R-MMU-191859)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11773003;15345747;17242355;17353360;19144319;21183079;21389246;21750661;23063131;31599954;9070939;9110173;9275227", "class_list": "", "function": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (By similarity). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09092", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0007409 axonogenesis;GO:0010975 regulation of neuron projection development;GO:0000387 spliceosomal snRNP assembly;GO:0006353 DNA-templated transcription termination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97801-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70492-1", "uniprot_id": "SNX3_MOUSE", "mass": 18762.0, "length": 162, "protein_name": "Sorting nexin-3", "gene_name": "Snx3", "organism": "Mouse", "refseq_name": "sorting nexin-3", "refseq_ac": "NP_059500", "gene_names_uniprotkb": "Snx3", "gene_names_refseq": "SDP3; Snx3", "protein_names_uniprotkb": "Sorting nexin-3; SDP3 protein", "protein_names_refseq": "sorting nexin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:54198); (R-MMU-3238698); (R-MMU-5689880)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "12079282;18632802;19576982;21750661;23416069;24129315;26740625;28011936;33214242;33947971;34428180;36288343;37828378", "class_list": "", "function": "Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (PubMed:19576982). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (By similarity). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (PubMed:18632802). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (By similarity). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (PubMed:23416069). Involved in regulation of neurite outgrowth in primary neurons (PubMed:19576982). Required for trafficking of WLS to the early endosome for recycling which promotes both canonical and non-canonical WNT signaling and is essential for neural tube closure (PubMed:33214242)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78ZM0", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0019903 protein phosphatase binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0010324 membrane invagination;GO:0010976 positive regulation of neuron projection development;GO:0009617 response to bacterium;GO:0030111 regulation of Wnt signaling pathway;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGQ8-1", "uniprot_id": "NCKX4_MOUSE", "mass": 68974.0, "length": 622, "protein_name": "Sodium/potassium/calcium exchanger 4", "gene_name": "Slc24a4", "organism": "Mouse", "refseq_name": "sodium/potassium/calcium exchanger 4 isoform 1 precursor", "refseq_ac": "NP_742164", "gene_names_uniprotkb": "Slc24a4; Nckx4", "gene_names_refseq": "A930002M03Rik; NCKX4; Slc24a4", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 4; Na(+)/K(+)/Ca(2+)-exchange protein 4; Solute carrier family 24 member 4", "protein_names_refseq": "K-dependent Na/Ca exchanger NCKX4; Na(+)/K(+)/Ca(2+)-exchange protein 4; sodium/potassium/calcium exchanger 4 isoform 1 precursor; sodium/potassium/calcium exchanger 4; solute carrier family 24 member 4", "tax_id": 10090, "disease": "amelogenesis imperfecta hypomaturation type 2A5 (Disease Ontology:DOID:0110063); pigmentation disease (Disease Ontology:DOID:10123); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:238384); (R-MMU-425561)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12379639;20173027;21750661;22057188;22677781;23375655;24621671;26247047;34428180", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:22057188). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (PubMed:22057188). May play a role in calcium transport during amelogenesis (PubMed:23375655)., [UniProtKB, PubMed, PubMed]; NCKX4 might be an important regulator of Ca(2+) transport during amelogenesis., [RefSeq, PubMed]; These findings support a key role for SLC24A4 in calcium transport during enamel formation., [RefSeq, PubMed]; These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLL5;Q8BLL7", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding;GO:0015293 symporter activity;GO:0005432 calcium:sodium antiporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:1903998 regulation of eating behavior;GO:0010628 positive regulation of gene expression;GO:0006874 intracellular calcium ion homeostasis;GO:0042756 drinking behavior", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CGQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJJ7-1", "uniprot_id": "PORCN_MOUSE", "mass": 52508.0, "length": 461, "protein_name": "Protein-serine O-palmitoleoyltransferase porcupine", "gene_name": "Porcn", "organism": "Mouse", "refseq_name": "protein-serine O-palmitoleoyltransferase porcupine isoform E", "refseq_ac": "NP_001295403", "gene_names_uniprotkb": "Porcn; Porc; Ppn", "gene_names_refseq": "2410004O13Rik; DXHXS7465e; Mg61; Mporc; Porcn; Ppn; mMg61; porc", "protein_names_uniprotkb": "Protein-serine O-palmitoleoyltransferase porcupine; 2.3.1.250; mPORC", "protein_names_refseq": "porcupine homolog; probable protein-cysteine N-palmitoyltransferase porcupine; protein-serine O-palmitoleoyltransferase porcupine isoform E; protein-serine O-palmitoleoyltransferase porcupine", "tax_id": 10090, "disease": "focal dermal hypoplasia (Disease Ontology:DOID:2120)", "pathway": " (mmu:53627)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10866835;12842094;17141155;21750661;22046319;24055053;24798332;25428506;34203471;34428180", "class_list": "", "function": "Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AC30;A2AC32;A2AC33;Q9CWT0;Q9JJJ8;Q9JJJ9;Q9JJK0", "ec_number_list": "2.3.1.250", "go_molecular_function": "GO:0017147 Wnt-protein binding;GO:0008374 O-acyltransferase activity;GO:1990698 palmitoleoyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0045234 protein palmitoleylation;GO:0006497 protein lipidation;GO:0016055 Wnt signaling pathway;GO:0009100 glycoprotein metabolic process;GO:0030258 lipid modification", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JJJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62141-1", "uniprot_id": "PP1B_MOUSE", "mass": 37187.0, "length": 327, "protein_name": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "gene_name": "Ppp1cb", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase PP1-beta catalytic subunit", "refseq_ac": "NP_766295", "gene_names_uniprotkb": "Ppp1cb", "gene_names_refseq": "1200010B19; Ppp1cb", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit; 3.1.3.16; 3.1.3.53; PP-1B", "protein_names_refseq": "PP-1B; serine/threonine-protein phosphatase PP1-beta catalytic subunit", "tax_id": 10090, "disease": "Noonan syndrome-like disorder with loose anagen hair 2 (Disease Ontology:DOID:0080693); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19046); (R-MMU-2565942); (R-MMU-5625740); (R-MMU-5627123); (R-MMU-5673000); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "14638860;16835242;21712997;21750661;21930935;2544298;26495903;30185619;31209405;37453647;37507081;39927985;40997131", "class_list": "", "function": "Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Smooth muscle-specific conditional PP1cbeta knockout decreased contractile force development in bladder, ileal, and aortic tissues and reduced mouse survival., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P37140;Q3TBE5;Q3TL90;Q542E7;Q8C285;Q9DBY2", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.6.5.2;3.6.4.13;2.7.11.1;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.74;3.1.3.53;2.3.2.27;2.7.11.21;2.7.7.19;3.1.3.27;3.1.3.52;2.7.7.52;3.1.3.86;3.1.3.36;2.7.1.78;2.7.11.26;3.1.27.-", "go_molecular_function": "GO:0050115 myosin-light-chain-phosphatase activity;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0030155 regulation of cell adhesion;GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P62141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQJ2-1", "uniprot_id": "PIHD1_MOUSE", "mass": 32209.0, "length": 290, "protein_name": "PIH1 domain-containing protein 1", "gene_name": "Pih1d1", "organism": "Mouse", "refseq_name": "PIH1 domain-containing protein 1", "refseq_ac": "NP_001265136", "gene_names_uniprotkb": "Pih1d1; Nop17", "gene_names_refseq": "1110061L23Rik; 4933413A04Rik; Nop17; Pih1d1", "protein_names_uniprotkb": "PIH1 domain-containing protein 1; Nucleolar protein 17 homolog", "protein_names_refseq": "PIH1 domain-containing protein 1; nucleolar protein 17 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68845)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17335777;21750661;21952136;24794838;30779550;31219806;34428180", "class_list": "", "function": "Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity)., [UniProtKB, UniProtKB]; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NV90", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051117 ATPase binding;GO:0051219 phosphoprotein binding;GO:0042393 histone binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0070761 pre-snoRNP complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1902661 positive regulation of glucose mediated signaling pathway;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62009-1", "uniprot_id": "POSTN_MOUSE", "mass": 93144.0, "length": 838, "protein_name": "Periostin", "gene_name": "Postn", "organism": "Mouse", "refseq_name": "periostin isoform 2 precursor", "refseq_ac": "NP_001185694", "gene_names_uniprotkb": "Postn; Osf2", "gene_names_refseq": "A630052E07Rik; OSF-2; Osf2; PLF; PN; Postn", "protein_names_uniprotkb": "Periostin; OSF-2; Osteoblast-specific factor 2; PN", "protein_names_refseq": "osteoblast specific factor 2 (fasciclin I-like); osteoblast-specific factor 2; periostin isoform 2 precursor; periostin-like factor", "tax_id": 10090, "disease": "bone structure disease (Disease Ontology:DOID:0080010); hypertension (Disease Ontology:DOID:10763); aggressive periodontitis (Disease Ontology:DOID:1474); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); degenerative disc disease (Disease Ontology:DOID:90); tendinitis (Disease Ontology:DOID:971)", "pathway": " (mmu:50706)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10404027;11335131;12213217;18450759;20181949;21750661;30084848;34428180;37507081;37828378;7663166;8363580", "class_list": "", "function": "Human cancer cell lines with reduced endogenous periostin gene expression that were infected with a recombinant rat periostin gene had reduced anchorage-independent growth, [RefSeq, PubMed]; Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:10404027). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (PubMed:20181949)., [UniProtKB, PubMed, PubMed]; This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMJ6;Q8K1K0", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0071307 cellular response to vitamin K;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0001953 negative regulation of cell-matrix adhesion;GO:0003073 regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q62009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88513-1", "uniprot_id": "GEMI_MOUSE", "mass": 23300.0, "length": 206, "protein_name": "Geminin", "gene_name": "Gmnn", "organism": "Mouse", "refseq_name": "geminin", "refseq_ac": "NP_065592", "gene_names_uniprotkb": "Gmnn", "gene_names_refseq": "Gem; Gmnn", "protein_names_uniprotkb": "Geminin", "protein_names_refseq": "geminin", "tax_id": 10090, "disease": "Meier-Gorlin syndrome 6 (Disease Ontology:DOID:0080517)", "pathway": " (mmu:57441); (R-MMU-68867); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12192004;15286659;15811859;21750661;28315936;9635433", "class_list": "", "function": "Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:12192004, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:12192004, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (By similarity). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Role in inhibiting Cdt1-MCM6 interactions as well as a novel intrinsic Cdt1 DNA binding activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0071163 DNA replication preinitiation complex assembly;GO:2000104 negative regulation of DNA-templated DNA replication;GO:0045892 negative regulation of DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88513-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TT00-1", "uniprot_id": "SP20H_MOUSE", "mass": 59519.0, "length": 530, "protein_name": "Transcription factor SPT20 homolog", "gene_name": "Supt20h; Supt20", "organism": "Mouse", "refseq_name": "transcription factor SPT20 homolog isoform 3", "refseq_ac": "NP_064379", "gene_names_uniprotkb": "Supt20h; Supt20; D3Ertd300e; Fam48a; Supt20", "gene_names_refseq": "D3Ertd300e; Fam48a; Supt20h; Supt20; p38IP", "protein_names_uniprotkb": "Transcription factor SPT20 homolog; p38-interacting protein; p38IP", "protein_names_refseq": "family with sequence similarity 48, member A; p38-interacting protein; protein FAM48A; suppressor of Ty 20; transcription factor (p38 interacting protein); transcription factor SPT20 homolog isoform 3; transcription factor SPT20 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:56790)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16751104;17242355;21183079;21750661;27894818;33109704;34428180;40997131", "class_list": "", "function": "Both p38 and p38IP are required for E-cadherin downregulation during gastrulation. Also, p38 regulates E-cadherin protein expression downstream from NCK-interacting kinase., [RefSeq, PubMed]; Gcn5 and Supt20 hypomorphs show similar defects in rostral-caudal somite patterning potentially suggesting shared mechanisms., [RefSeq, PubMed]; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG53;Q9JLS9", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0000124 SAGA complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing;GO:0007369 gastrulation;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TT00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZM2-1", "uniprot_id": "SH2B1_MOUSE", "mass": 79625.0, "length": 756, "protein_name": "SH2B adapter protein 1", "gene_name": "Sh2b1", "organism": "Mouse", "refseq_name": "SH2B adapter protein 1 isoform 1", "refseq_ac": "NP_001074928", "gene_names_uniprotkb": "Sh2b1; Sh2bpsm1", "gene_names_refseq": "C530001K22Rik; Irip; Psm; SH2-Bb; SH2-B; Sh2b1; Sh2bpsm1; mKIAA1299", "protein_names_uniprotkb": "SH2B adapter protein 1; PSM; Pro-rich, PH and SH2 domain-containing signaling mediator; SH2 domain-containing protein 1B; SH2-B PH domain-containing signaling mediator 1", "protein_names_refseq": "SH2 domain-containing protein 1B; SH2-B PH domain containing signaling mediator 1; SH2B adapter protein 1 isoform 1; SH2B adapter protein 1; pro-rich, PH and SH2 domain-containing signaling mediator", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 220-kb (Disease Ontology:DOID:0060398)", "pathway": " (mmu:20399); (R-MMU-1170546); (R-MMU-982772); (R-MMU-983231)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10594240;11502739;15316008;16098827;16824542;17242355;18247337;21183079;21750661;24129315;26495903;31219806;35077201;35390677;36799031;9343427;9452421;9498552", "class_list": "", "function": "Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity (By similarity). Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis, according the order: isoform 3 > isoform 4 > isoform 1 > isoform 2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; An essential role of the SH2B1 variants in the activation of the Src kinase and the resulting mitogenic response--extending to phenotypic cell transformation and involving the established Src substrate STAT3, [RefSeq, PubMed]; Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson's disease via promoting PLIN4 degradation., [RefSeq, PubMed]; Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance., [RefSeq, PubMed]; The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54867;Q05DJ7;Q792R7;Q91ZM3;Q91ZV5;Q9WVM5", "ec_number_list": "", "go_molecular_function": "GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0001726 ruffle", "go_biological_process": "GO:2000278 regulation of DNA biosynthetic process;GO:0035556 intracellular signal transduction;GO:0030032 lamellipodium assembly;GO:0048870 cell motility;GO:0045840 positive regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91ZM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35621-1", "uniprot_id": "PMM1_MOUSE", "mass": 29775.0, "length": 262, "protein_name": "Phosphomannomutase 1", "gene_name": "Pmm1", "organism": "Mouse", "refseq_name": "phosphomannomutase 1 isoform 1", "refseq_ac": "NP_038900", "gene_names_uniprotkb": "Pmm1", "gene_names_refseq": "Pmm1", "protein_names_uniprotkb": "Phosphomannomutase 1; 5.4.2.8; PMM 1", "protein_names_refseq": "PMM 1; Secp53 homolog; phosphomannomutase 1 isoform 1", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552)", "pathway": " (mmu:29858); (R-MMU-446205)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16115222;16847318;18927083;20523973;21183079;21750661;30084848;34428180", "class_list": "glycogene", "function": "Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain., [UniProtKB, PubMed, UniProtKB, UniProtKB]; PMM1 is responsible for the degradation of Glc-1,6-P(2) in brain, [RefSeq, PubMed]; Pmm1 activity in jejunum increased during the early stages of life, and it decreased at 1 month old, as does the amount of mannose incorporated into glycoproteins, whereas in the ileum, they were not affected by age., [RefSeq, PubMed]; Pmm1 immunoreactivity seen in prenatal brain until postnatal and adult stage and restricted in neuronal cell bodies., [RefSeq, PubMed]; The normal phenotype of Pmm1-deficient mice suggests that Pmm1 is not essential for normal mouse development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.4.2.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004615 phosphomannomutase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006487 protein N-linked glycosylation;GO:0006013 mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35621-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3KNI6-1", "uniprot_id": "DAAF6_MOUSE", "mass": 24501.0, "length": 218, "protein_name": "Dynein axonemal assembly factor 6", "gene_name": "Dnaaf6", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 6", "refseq_ac": "NP_083338", "gene_names_uniprotkb": "Dnaaf6; Pih1d3", "gene_names_refseq": "4930521A18Rik; Dnaaf6rt; Dnaaf6; Pih1d3", "protein_names_uniprotkb": "Dynein axonemal assembly factor 6; PIH1 domain-containing protein 3", "protein_names_refseq": "PIH1 domain containing 3; PIH1 domain-containing protein 3; dynein assembly factor 6, axonemal; dynein axonemal assembly factor 6; protein PIH1D3", "tax_id": 10090, "disease": "primary ciliary dyskinesia 36 (Disease Ontology:DOID:0111850); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:74708)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24421334", "class_list": "", "function": "Pih1d3 contributes to cytoplasmic preassembly of dynein complexes in spermatogenic cells by stabilizing and promoting complex formation by ODA and IDA proteins., [RefSeq, PubMed]; Plays a role in cytoplasmic pre-assembly of axonemal dynein., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:0036159 inner dynein arm assembly;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KNI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHE1-1", "uniprot_id": "PITM3_MOUSE", "mass": 106462.0, "length": 974, "protein_name": "Membrane-associated phosphatidylinositol transfer protein 3", "gene_name": "Pitpnm3", "organism": "Mouse", "refseq_name": "membrane-associated phosphatidylinositol transfer protein 3 isoform 1", "refseq_ac": "NP_001020098", "gene_names_uniprotkb": "Pitpnm3; Nir1", "gene_names_refseq": "A330068P14Rik; Ackr6; Gm880; Pitpnm3", "protein_names_uniprotkb": "Membrane-associated phosphatidylinositol transfer protein 3; NIR-1; PITPnm 3; Phosphatidylinositol transfer protein, membrane-associated 3; Pyk2 N-terminal domain-interacting receptor 1", "protein_names_refseq": "NIR-1; PITPnm 3; membrane-associated phosphatidylinositol transfer protein 3 isoform 1; membrane-associated phosphatidylinositol transfer protein 3; phosphatidylinositol transfer protein, membrane-associated 3; pyk2 N-terminal domain-interacting receptor 1", "tax_id": 10090, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); cone-rod dystrophy 5 (Disease Ontology:DOID:0111010)", "pathway": " (mmu:327958); (R-MMU-1483226)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21183079;25428506;35820727", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9531, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6QRE8;Q3UH22;Q5RIT9", "ec_number_list": "", "go_molecular_function": "GO:0004620 phospholipase activity;GO:0005509 calcium ion binding;GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0012505 endomembrane system;GO:0044297 cell body;GO:0042995 cell projection", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UHE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZX5-1", "uniprot_id": "PINX1_MOUSE", "mass": 37221.0, "length": 332, "protein_name": "PIN2/TERF1-interacting telomerase inhibitor 1", "gene_name": "Pinx1", "organism": "Mouse", "refseq_name": "PIN2/TERF1-interacting telomerase inhibitor 1", "refseq_ac": "NP_082504", "gene_names_uniprotkb": "Pinx1; Lpts", "gene_names_refseq": "2210403I16Rik; 2610028A01Rik; 67-11-3; LPTS1; LPTS; Pinx1", "protein_names_uniprotkb": "PIN2/TERF1-interacting telomerase inhibitor 1; 67-11-3 protein; LPTS1; Liver-related putative tumor suppressor; Pin2-interacting protein X1; TRF1-interacting protein 1", "protein_names_refseq": "PIN2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PIN2/TRF1-interacting protein; TRF1-interacting protein 1; liver-related putative tumor suppressor", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:72400)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11701125;21183079;21436583;32157956;34657040;40997131", "class_list": "", "function": "Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity)., [UniProtKB]; PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis., [RefSeq, PubMed]; PinX1 heterozygosity and PinX1 knockdown in mouse embryonic fibroblasts activated telomerase and led to concomitant telomerase-dependent chromosomal instability., [RefSeq, PubMed]; PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BS4;Q3V450;Q8C6E5;Q91WZ9;Q9D0C2", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0070034 telomerase RNA binding;GO:0010521 telomerase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005819 spindle;GO:0000776 kinetochore", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0070198 protein localization to chromosome, telomeric region;GO:0031647 regulation of protein stability;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02384-1", "uniprot_id": "SOS2_MOUSE", "mass": 153127.0, "length": 1333, "protein_name": "Son of sevenless homolog 2", "gene_name": "Sos2", "organism": "Mouse", "refseq_name": "son of sevenless homolog 2 isoform X1", "refseq_ac": "XP_006515698", "gene_names_uniprotkb": "Sos2", "gene_names_refseq": "SOS-2; Sos2; mSOS-2", "protein_names_uniprotkb": "Son of sevenless homolog 2; SOS-2; mSOS-2", "protein_names_refseq": "son of sevenless homolog 2 isoform X1", "tax_id": 10090, "disease": "Noonan syndrome 9 (Disease Ontology:DOID:0060587)", "pathway": " (mmu:20663); (R-MMU-193648); (R-MMU-416482); (R-MMU-8983432); (R-MMU-9013149)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10938118;1631150;21750661;22872234;24129315;30084848;30779550;31219806;31599954;34203471;34428180;36210013", "class_list": "", "function": "Acts as guanine nucleotide exchange factor (GEF) for RAS proteins. Catalyzes the GDP-to-GTP exchange, resulting in an increase of the active GTP-bound form of HRAS. Acts as a key modulator of PI3K-AKT signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0002260 lymphocyte homeostasis;GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q02384-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ75-1", "uniprot_id": "NDUA2_MOUSE", "mass": 10916.0, "length": 99, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "gene_name": "Ndufa2", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "refseq_ac": "NP_035015", "gene_names_uniprotkb": "Ndufa2", "gene_names_refseq": "B8; C1-B8; CI-B8; Ndufa2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; CI-B8; Complex I-B8; NADH-ubiquinone oxidoreductase B8 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH-ubiquinone oxidoreductase B8 subunit; complex I-B8", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 13 (Disease Ontology:DOID:0112076); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:17991); (R-MMU-611105); (R-MMU-6799198); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10318868;12427551;15341729;23038253;23576753;23806337;25605945;34428180;36288343;37453647;37507081;38575788;39927985", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Differentially expressed in the brains of four mice strains; expression pattern follows ethanol preference of the strains [(NADH-ubiquinone oxidoreductase B8 subunit], [RefSeq, PubMed]; The authors determine the NMR structure of the oxidized human NDUFA2 protein, also known as B8, and report that its structure and redox potential is similar to that of thioredoxins. The highly conserved residues on the surface most likely form the protein-protein interaction site of this subunit with the large multimeric complex I., [RefSeq, PubMed]; The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFA2 may incorporate into the holo-complex I enzyme as an assembly intermediate or as free monomers. The authors conclude that nuclear-encoded subunits incorporate into the holo-enzyme in a subunit-specific manner., [RefSeq, PubMed]; This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUB2", "ec_number_list": "", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0001835 blastocyst hatching;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CQ75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0E0-1", "uniprot_id": "NCDN_MOUSE", "mass": 78895.0, "length": 729, "protein_name": "Neurochondrin", "gene_name": "Ncdn", "organism": "Mouse", "refseq_name": "neurochondrin isoform 1", "refseq_ac": "NP_036116", "gene_names_uniprotkb": "Ncdn; Kiaa0607; Sfap75", "gene_names_refseq": "MMS10-AE; Ms10ae; Ncdn; mKIAA0607; norbin", "protein_names_uniprotkb": "Neurochondrin; M-Sema F-associating protein of 75 kDa; Norbin", "protein_names_refseq": "M-Sema F-associating protein of 75 kDa; minisatellite 10ae detected by probe MMS10; neurochondrin isoform 1; neurochondrin-1; neurochondrin-2", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:26562)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10231559;11162505;11445285;14559245;15007648;15790563;18572016;20007903;24129315;25428507;26195764;26792863;27802388;31219806;33300544;34402884;34428180;34907024", "class_list": "", "function": "A novel mechanism of P-Rex1 regulation through the GPCR-adaptor protein Norbin., [RefSeq, PubMed]; Neurochondrin/norbin gene function is essential for the early embryogenesis, [RefSeq, PubMed]; Norbin is a regulator of adult hippocampal neurogenesis and that its deletion causes depressive-like behaviors., [RefSeq, PubMed]; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth., [UniProtKB, PubMed, PubMed, PubMed]; Regulation of Metabotropic Glutamate Receptor Internalization and Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein Norbin., [RefSeq, PubMed]; The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCW4;Q80TW1;Q91YH7;Q9CW81;Q9QUQ0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0031175 neuron projection development;GO:0045453 bone resorption;GO:0048168 regulation of neuronal synaptic plasticity;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9Z0E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSC1-1", "uniprot_id": "PRC2A_MOUSE", "mass": 229203.0, "length": 2158, "protein_name": "Protein PRRC2A", "gene_name": "Prrc2a", "organism": "Mouse", "refseq_name": "protein PRRC2A isoform 2", "refseq_ac": "NP_001185973", "gene_names_uniprotkb": "Prrc2a; Bat2", "gene_names_refseq": "3110039B05Rik; Bat-2; Bat2; D17H6S51E; G2; Prrc2a; Wbp12; mKIAA4178", "protein_names_uniprotkb": "Protein PRRC2A; HLA-B-associated transcript 2; Proline-rich and coiled-coil-containing protein 2A", "protein_names_refseq": "HLA-B associated transcript 2; large proline-rich protein BAT2; proline-rich and coiled-coil-containing protein 2A; protein PRRC2A isoform 2; protein PRRC2A", "tax_id": 10090, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:53761)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;14656967;17242355;19131326;19144319;21183079;21750661;23806337;24129315;29187734;30514900;31219806;32782141;34428180;34678516;34887587;36852467;40885482", "class_list": "", "function": "May play a role in the regulation of pre-mRNA splicing., [UniProtKB]; The results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m(6)A-specific binding protein, suggesting the functional importance of the m(6)A mRNA methylation in glial cells., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q923A9;Q9Z1R1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q7TSC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53808-1", "uniprot_id": "PPCT_MOUSE", "mass": 24785.0, "length": 214, "protein_name": "Phosphatidylcholine transfer protein", "gene_name": "Pctp", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pctp; Stard2", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylcholine transfer protein; PC-TP; START domain-containing protein 2; StAR-related lipid transfer protein 2; StARD2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1483191); (R-MMU-77289)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10500206;10542325;17704541;21750661;25428506;8645232", "class_list": "", "function": "Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZX0;Q9R058", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0031210 phosphatidylcholine binding;GO:0008525 phosphatidylcholine transporter activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0015914 phospholipid transport;GO:0120163 negative regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53808-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62137-1", "uniprot_id": "PP1A_MOUSE", "mass": 37540.0, "length": 330, "protein_name": "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "gene_name": "Ppp1ca", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "refseq_ac": "NP_114074", "gene_names_uniprotkb": "Ppp1ca; Ppp1a", "gene_names_refseq": "Ppp1ca; Ppp1c; dism2", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; 3.1.3.16; PP-1A", "protein_names_refseq": "PP-1A; serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19045); (R-MMU-180024); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "14638860;16835242;17609112;18160256;19131326;21183079;21712997;21930935;22215812;23806337;24156551;25428506;30084848;33300544;34428180;35080339;37649137;39256359;8077208;9399575", "class_list": "", "function": "Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation., [RefSeq, PubMed]; PP1A prevents ROS-induced pyroptosis by inhibiting MAPK/caspase-3 in mouse adipose tissue., [RefSeq, PubMed]; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (By similarity). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (By similarity). Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity). May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II (By similarity). Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (By similarity). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (By similarity). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (By similarity). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (By similarity). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (PubMed:17609112, PubMed:22215812). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997, PubMed:21930935). May dephosphorylate CSNK1D and CSNK1E (PubMed:21930935). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P08129;P20653;P22802;Q3U7G7;Q9Z1G2", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.6.4.13;2.7.11.1;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.74;3.1.3.53;2.3.2.27;2.7.7.19;3.1.3.27;3.1.3.52;2.7.7.52;3.1.3.86;3.1.3.36;2.7.1.78;2.7.11.26;3.1.27.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0043021 ribonucleoprotein complex binding;GO:0046914 transition metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0098978 glutamatergic synapse;GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0005981 regulation of glycogen catabolic process;GO:0043247 telomere maintenance in response to DNA damage;GO:0006417 regulation of translation;GO:0010288 response to lead ion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P62137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P3Y9-1", "uniprot_id": "PONL1_MOUSE", "mass": 62519.0, "length": 559, "protein_name": "Podocan-like protein 1", "gene_name": "Podnl1", "organism": "Mouse", "refseq_name": "podocan-like protein 1 precursor", "refseq_ac": "NP_001013402", "gene_names_uniprotkb": "Podnl1; Gm506", "gene_names_refseq": "5832418A03Rik; Gm506; Podnl1", "protein_names_uniprotkb": "Podocan-like protein 1", "protein_names_refseq": "podocan-like protein 1 precursor; podocan-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:244550)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21672516", "class_list": "", "function": "A novel SLRP member, 'Podocan-like (Podnl) protein' identified by a bioinformatics approach was characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J142;A1X874", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P3Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERT9-1", "uniprot_id": "PPR1A_MOUSE", "mass": 18718.0, "length": 171, "protein_name": "Protein phosphatase 1 regulatory subunit 1A", "gene_name": "Ppp1r1a", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 1A", "refseq_ac": "NP_067366", "gene_names_uniprotkb": "Ppp1r1a", "gene_names_refseq": "0610038N18Rik; I-1; Ppp1r1a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 1A; I-1; IPP-1; Protein phosphatase inhibitor 1", "protein_names_refseq": "IPP-1; inhibitor-1; protein phosphatase 1 regulatory subunit 1A; protein phosphatase inhibitor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58200)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10960791;18190909;21183079;22777184;26192747;29059150;30772395;36018458", "class_list": "", "function": "A2a receptor increase cell viability, proliferation and insulin release through PKA/Akt/IPP-1/CREB signaling pathway, [RefSeq, PubMed]; Exploring prognostic value and regulation network of PPP1R1A in hepatocellular carcinoma., [RefSeq, PubMed]; High PPP1R1A expression is associated with ewing sarcoma tumorigenesis and metastasis., [RefSeq, PubMed]; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ERT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES82-1", "uniprot_id": "POPD2_MOUSE", "mass": 41252.0, "length": 367, "protein_name": "Popeye domain-containing protein 2", "gene_name": "Popdc2", "organism": "Mouse", "refseq_name": "popeye domain-containing protein 2 isoform 2", "refseq_ac": "NP_071713", "gene_names_uniprotkb": "Popdc2; Pop2", "gene_names_refseq": "Pop2; Popdc2", "protein_names_uniprotkb": "Popeye domain-containing protein 2; Popeye protein 2", "protein_names_refseq": "popeye domain-containing protein 2 isoform 2; popeye domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:64082)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10882522;18189275;21183079;22354168;26411676;32535041", "class_list": "", "function": "Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density., [UniProtKB, UniProtKB, PubMed]; POPDC2 a novel susceptibility gene for conduction disorders., [RefSeq, PubMed]; Popdc1 and Popdc2 proteins interact with the potassium channel TREK-1, which leads to increased cell surface expression and enhanced current density, [RefSeq, PubMed]; Popdc2 is expressed in various muscle and nonmuscle cell types during embryonic development and in postnatal life, [RefSeq, PubMed]; Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis., [RefSeq, PubMed]; This gene encodes a member of the Popeye domain containing family of membrane proteins. Proteins of this family contain three helical transmembrane domains and a conserved intracellular Popeye domain. In the adult mouse, this gene is expressed at high levels in cardiac myocytes, and mice deficient for this gene develop stress-induced cardiac pacemaker dysfunction. The protein binds to a two-pore domain potassium channel and recruits it to the plasma membrane. Cyclic adenosine monophosphate negatively regulates this interaction through the Popeye domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030552 cAMP binding", "go_cellular_component": "GO:0016020 membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0060931 sinoatrial node cell development;GO:0007507 heart development;GO:0042391 regulation of membrane potential;GO:0051146 striated muscle cell differentiation;GO:0002027 regulation of heart rate", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ES82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5IBH7-2", "uniprot_id": "SPDYA_MOUSE", "mass": 36115.0, "length": 310, "protein_name": "Speedy protein A", "gene_name": "Spdya", "organism": "Mouse", "refseq_name": "speedy protein A isoform 2", "refseq_ac": "NP_001136103", "gene_names_uniprotkb": "Spdya; Spdy1", "gene_names_refseq": "4921517J08Rik; 4930548B21Rik; GS4; MLZ-465; Spdy1; Spdya", "protein_names_uniprotkb": "Speedy protein A; MLZ-465; Protein expressed in male leptotene and zygotene spermatocytes 465; RINGO A; Rapid inducer of G2/M progression in oocytes A; Speedy-1; Spy1; mSpy/Ringo A", "protein_names_refseq": "RINGO A; mSpy/Ringo A; protein expressed in male leptotene and zygotene spermatocytes 465; rapid inducer of G2/M progression in oocytes A; speedy A1; speedy A2; speedy A; speedy homolog 1; speedy homolog A; speedy protein A isoform 2; speedy protein A; speedy-1; spermatogenesis related protein Gs4; spy1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70891)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11730327;15611625;18483240;20339383;21183079;34039995;36443440", "class_list": "", "function": "Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity)., [UniProtKB, PubMed, UniProtKB]; SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1., [RefSeq, PubMed]; The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. Publication Status: Online-Only, [RefSeq, PubMed]; The Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B8JJC0;Q5IBH8;Q8C5T5", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0001741 XY body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0045860 positive regulation of protein kinase activity;GO:0006974 DNA damage response;GO:0016233 telomere capping", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5IBH7-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SQF8-1", "uniprot_id": "SP30L_MOUSE", "mass": 20745.0, "length": 182, "protein_name": "Histone deacetylase complex subunit SAP30L", "gene_name": "Sap30l", "organism": "Mouse", "refseq_name": "histone deacetylase complex subunit SAP30L", "refseq_ac": "NP_001074637", "gene_names_uniprotkb": "Sap30l", "gene_names_refseq": "2310079P12Rik; L55; Sap30l", "protein_names_uniprotkb": "Histone deacetylase complex subunit SAP30L; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like", "protein_names_refseq": "histone deacetylase complex subunit SAP30L; sin3 corepressor complex subunit SAP30L; sin3-associated protein p30-like; sin3A-associated protein p30-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:50724); (R-MMU-3214815)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17242355;21183079;25428506", "class_list": "", "function": "Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q504M9;Q9CUZ7", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5SQF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R191-1", "uniprot_id": "SNG3_MOUSE", "mass": 24561.0, "length": 229, "protein_name": "Synaptogyrin-3", "gene_name": "Syngr3", "organism": "Mouse", "refseq_name": "synaptogyrin-3", "refseq_ac": "NP_035652", "gene_names_uniprotkb": "Syngr3", "gene_names_refseq": "Syngr3", "protein_names_uniprotkb": "Synaptogyrin-3", "protein_names_refseq": "Sgyr III; synaptogryin III; synaptogyrin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20974)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10383386;14755516;19357284;33300544;33472038;34203471;36624932;38175724", "class_list": "", "function": "A novel interaction between dopamine transporter (DAT) and synaptogyrin-3 suggests a physical and functional link between DAT and the vesicular dopamine system., [RefSeq, PubMed]; In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2[R1441G] mutant mouse model of Parkinson's disease., [RefSeq, PubMed]; Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation., [RefSeq, PubMed]; May play a role in regulated exocytosis (PubMed:10383386). May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal (PubMed:19357284)., [UniProtKB, PubMed, PubMed]; Subcellular fractionation and immunoprecipitation of synaptic vesicles from mouse brain show that synaptogyrin 3 is associated with synaptic vesicles and can reside on the same synaptic vesicle with synaptogyrin 1., [RefSeq, PubMed]; The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVG8", "ec_number_list": "", "go_molecular_function": "GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0051580 regulation of neurotransmitter uptake;GO:0010807 regulation of synaptic vesicle priming;GO:0032411 positive regulation of transporter activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R191-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ET39-1", "uniprot_id": "SLAF6_MOUSE", "mass": 38638.0, "length": 351, "protein_name": "SLAM family member 6", "gene_name": "Slamf6", "organism": "Mouse", "refseq_name": "SLAM family member 6 isoform 2 precursor", "refseq_ac": "NP_001334115", "gene_names_uniprotkb": "Slamf6; Ly108", "gene_names_refseq": "KAL1b; KAL1; Ly108; NTB-A; NTBA; SF2000; Slamf6", "protein_names_uniprotkb": "SLAM family member 6; Lymphocyte antigen 108", "protein_names_refseq": "SLAM family member 6 isoform 2 precursor; lymphocyte antigen 108", "tax_id": 10090, "disease": "", "pathway": " (mmu:30925); (R-MMU-198933)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11132158;15879084;18031695;19648922;20153220;21422172;21750661;22683125;25801429;25926831;26495903;28011936;33762352;34428180;36902453", "class_list": "", "function": "Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions., [RefSeq, PubMed]; Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Following targeted disruption of the LY108 gene, CD4+ T cell and innate responses are defective; a surprising role for Ly108 is revealed in the control of responses to bacteria by neutrophils, while macrophage functions are intact., [RefSeq, PubMed]; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (By similarity). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (By similarity). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695). Promotes T cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (By similarity). Promotes recruitment of RORC to the IL-17 promoter (By similarity). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response (PubMed:25926831). In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP (PubMed:22683125). However, reported to mediated T-cell adhesion, to participate in stable T-cell:B-cell interactions and to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (PubMed:20153220, PubMed:25801429). Involved in regulation of autoimmunity. Isoform 3 may be suppressor of pathogenic T-cell proliferation (PubMed:21422172)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "C6ESQ1;Q9ET40", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0032740 positive regulation of interleukin-17 production;GO:0006955 immune response;GO:0045087 innate immune response;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9ET39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35423-1", "uniprot_id": "AGT1_MOUSE", "mass": 45912.0, "length": 414, "protein_name": "Alanine--glyoxylate aminotransferase", "gene_name": "Agxt", "organism": "Mouse", "refseq_name": "alanine--glyoxylate aminotransferase isoform 1 precursor", "refseq_ac": "NP_057911", "gene_names_uniprotkb": "Agxt; Agxt1", "gene_names_refseq": "AGT; Agt1; Agxt1; Agxt; SPT", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase; 2.6.1.44; 2.6.1.51; AGT; SPT; Serine--pyruvate aminotransferase, mitochondrial", "protein_names_refseq": "alanine--glyoxylate aminotransferase isoform 1 precursor; alanine-glyoxylate aminotransferase 1; serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal; serine-pyruvate aminotransferase", "tax_id": 10090, "disease": "primary hyperoxaluria type 1 (Disease Ontology:DOID:0111670); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (mmu:11611); (R-MMU-389661); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11225057;17110443;23576753;23806337;34428180;37453647", "class_list": "", "function": "Catalyzes the transamination between L-serine and pyruvate and weakly contributes to gluconeogenesis from the L-serine metabolism., [UniProtKB, UniProtKB]; Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification., [UniProtKB, UniProtKB]; Expressed wild-type human AGT1 was predominantly localized in mouse hepatocellular peroxisomes, whereas the most common mutant form of AGT1 (G170R) was localized predominantly in the mitochondria, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R128", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;2.6.1.40;2.6.1.18;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0004760 L-serine-pyruvate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0046724 oxalic acid secretion;GO:0007219 Notch signaling pathway;GO:0051384 response to glucocorticoid;GO:0046487 glyoxylate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35423-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35718-1", "uniprot_id": "SOCS3_MOUSE", "mass": 24776.0, "length": 225, "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "Socs3", "organism": "Mouse", "refseq_name": "suppressor of cytokine signaling 3", "refseq_ac": "NP_031733", "gene_names_uniprotkb": "Socs3; Cis3; Cish3", "gene_names_refseq": "Cis3; Cish3; EF-10; Ef10; SSI-3; Socs3; Ssi3", "protein_names_uniprotkb": "Suppressor of cytokine signaling 3; CIS-3; Cytokine-inducible SH2 protein 3; Protein EF-10; SOCS-3", "protein_names_refseq": "CIS-3; E2a-Pbx1 target gene in fibroblasts 10; STAT-induced STAT inhibitor 3; cytokine inducible SH2-containing protein 3; suppressor of cytokine signaling 3", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); status epilepticus (Disease Ontology:DOID:1824); invasive ductal carcinoma (Disease Ontology:DOID:3008); cholangiocarcinoma (Disease Ontology:DOID:4947); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12702); (R-MMU-1059683); (R-MMU-877300); (R-MMU-877312); (R-MMU-8849474); (R-MMU-8951664); (R-MMU-909733); (R-MMU-9705462); (R-MMU-983168)", "pathway_count": 9, "publication_count": 18, "publication_id_list": "10359822;10490101;10821852;10882725;12242343;12754505;12847520;15173187;15213237;16630890;16905102;23019338;24997069;30236924;31219806;9032278;9202125;9889194", "class_list": "glycogene", "function": "SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway (By similarity). Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors (PubMed:10821852, PubMed:12754505, PubMed:9889194). Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling (PubMed:12754505, PubMed:9889194). Suppresses fetal liver erythropoiesis (PubMed:10490101). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (PubMed:12847520). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Upon OSM stimulation, negatively regulates the JAK-STAT signaling mediated through type II OSM receptor complex by interacting directly with JAK1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97803;Q3U7X5", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004860 protein kinase inhibitor activity;GO:0035198 miRNA binding;GO:0030292 protein tyrosine kinase inhibitor activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0050728 negative regulation of inflammatory response;GO:1990830 cellular response to leukemia inhibitory factor;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O35718-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61807-1", "uniprot_id": "SNN_MOUSE", "mass": 9501.0, "length": 88, "protein_name": "Stannin", "gene_name": "Snn", "organism": "Mouse", "refseq_name": "stannin", "refseq_ac": "NP_033249", "gene_names_uniprotkb": "Snn", "gene_names_refseq": "2810407J07Rik; Snn", "protein_names_uniprotkb": "Stannin", "protein_names_refseq": "stannin", "tax_id": 10090, "disease": "", "pathway": " (mmu:20621)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15345747;21183079;27015288;9657854", "class_list": "", "function": "Plays a role in the toxic effects of organotins (By similarity). Plays a role in endosomal maturation (PubMed:27015288)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88369", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPQ3-1", "uniprot_id": "SHPRH_MOUSE", "mass": 191490.0, "length": 1674, "protein_name": "E3 ubiquitin-protein ligase SHPRH", "gene_name": "Shprh", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SHPRH isoform a", "refseq_ac": "NP_001071175", "gene_names_uniprotkb": "Shprh", "gene_names_refseq": "2610103K11Rik; D230017O13Rik; E130018M05; Shprh", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SHPRH; 2.3.2.27; 3.6.4.-; RING-type E3 ubiquitin transferase SHPRH; SNF2, histone-linker, PHD and RING finger domain-containing helicase", "protein_names_refseq": "E3 ubiquitin-protein ligase SHPRH isoform a; E3 ubiquitin-protein ligase SHPRH; RING-type E3 ubiquitin transferase SHPRH; SNF2, histone-linker, PHD and RING finger domain-containing helicase", "tax_id": 10090, "disease": "", "pathway": " (mmu:268281); (R-MMU-8866654)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12837266;21183079;21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ27;Q7TQ28;Q7TQ29;Q8BKE2;Q8BUW0;Q922Q3", "ec_number_list": "2.3.2.23;2.3.2.27;3.6.4.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0006334 nucleosome assembly;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TPQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSY8-1", "uniprot_id": "SGO2A_MOUSE", "mass": 130277.0, "length": 1164, "protein_name": "Shugoshin 2A", "gene_name": "Sgo2a", "organism": "Mouse", "refseq_name": "shugoshin 2A isoform 2", "refseq_ac": "NP_001171338", "gene_names_uniprotkb": "Sgo2a; Sgo2; Sgol2a; Sgol2", "gene_names_refseq": "1110007N04Rik; 4932411A20Rik; 5730576N04Rik; D1Ertd8e; Sgo2a; Sgol2a; Sgol2; Tripin", "protein_names_uniprotkb": "Shugoshin 2A; Shugoshin-2; Shugoshin-like 2", "protein_names_refseq": "sgo2; shugoshin 2A isoform 2; shugoshin 2; shugoshin-like 2a; shugoshin-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68549); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "17205076;18084284;18765791;34418053", "class_list": "", "function": "Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase., [UniProtKB, PubMed, UniProtKB, PubMed]; Results show that shugoshin Sgo2 is expressed in germ cells., [RefSeq, PubMed]; SGOL2 is necessary for protecting centromeric cohesion during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a premature release of the meiosis-specific REC8 cohesin complexes from anaphase I centromeres, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q811I4;Q8C9C4;Q8CGJ4;Q9CS55", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0010789 meiotic sister chromatid cohesion involved in meiosis I;GO:0051301 cell division;GO:0007143 female meiotic nuclear division;GO:0051754 meiotic sister chromatid cohesion, centromeric", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TSY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZU3-1", "uniprot_id": "MTREX_MOUSE", "mass": 117636.0, "length": 1040, "protein_name": "Exosome RNA helicase MTR4", "gene_name": "Mtrex", "organism": "Mouse", "refseq_name": "exosome RNA helicase MTR4", "refseq_ac": "NP_082427", "gene_names_uniprotkb": "Mtrex; Skiv2l2", "gene_names_refseq": "2610528A15Rik; Mtrex; Skiv2l2; mKIAA0052", "protein_names_uniprotkb": "Exosome RNA helicase MTR4; 3.6.4.13; ATP-dependent helicase SKIV2L2; Superkiller viralicidic activity 2-like 2; TRAMP-like complex helicase", "protein_names_refseq": "ATP-dependent helicase SKIV2L2; TRAMP-like complex helicase; exosome RNA helicase MTR4; superkiller viralicidic activity 2-like 2", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:72198); (R-MMU-6791226); (R-MMU-72163); (R-MMU-9930044)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21467735;23806337;28351885;28431250;31219806;34428180;39627609", "class_list": "", "function": "Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand. Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (By similarity). Plays a role in DNA damage response (By similarity)., [UniProtKB, UniProtKB]; SKIV2L2 is an RNA-binding protein localized to the nucleus in the round spermatids of mice, [RefSeq, PubMed]; Skiv2l2 knockdown cells accumulated replication-dependent histone mRNAs, among other RNAs, that could impede mitotic progression and indirectly trigger differentiation., [RefSeq, PubMed]; Study reports that the noncoding RNA processing activity of RNA exosome, a 3'-5' RNA exonuclease, controls sense and antisense strand DNA mutagenesis, and prevents an increased asymmetric mutagenesis burden using a mechanism that relies on the unexpected DNA/RNA hybrid unwinding activities of the Mtr4 and senataxin RNA helicases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.2.1.8;3.1.-.-;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;2.1.1.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;3.4.19.12;7.2.2.-;2.7.1.78;7.6.2.16;2.7.11.1;2.7.7.19;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.1.26.-;3.4.22.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0006974 DNA damage response;GO:0008380 RNA splicing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CZU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TWW8-1", "uniprot_id": "SRSF6_MOUSE", "mass": 39025.0, "length": 339, "protein_name": "Serine/arginine-rich splicing factor 6", "gene_name": "Srsf6", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 6", "refseq_ac": "NP_080775", "gene_names_uniprotkb": "Srsf6; Sfrs6; Srp55", "gene_names_refseq": "1210001E11Rik; Sfrs6; Srsf6", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 6; Pre-mRNA-splicing factor SRP55; Splicing factor, arginine/serine-rich 6", "protein_names_refseq": "pre-mRNA-splicing factor SRP55; serine/arginine-rich splicing factor 6; splicing factor, arginine/serine-rich 6", "tax_id": 10090, "disease": "spermatogenic failure 3 (Disease Ontology:DOID:0070168); Huntington's disease (Disease Ontology:DOID:12858); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); lung cancer (Disease Ontology:DOID:1324); colon adenocarcinoma (Disease Ontology:DOID:234); skin cancer (Disease Ontology:DOID:4159); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:67996)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10823932;12549914;17242355;21183079;21750661;23806337;31219806;34428180;34614409;35820727;36210013;36288343;36409059;40885482", "class_list": "", "function": "DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing., [RefSeq, PubMed]; Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity)., [UniProtKB]; SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJV5;Q921K3;Q9DBP1", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0061041 regulation of wound healing;GO:0010629 negative regulation of gene expression;GO:0032868 response to insulin;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3TWW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V9W2-1", "uniprot_id": "SR1IP_MOUSE", "mass": 18151.0, "length": 153, "protein_name": "Protein SREK1IP1", "gene_name": "Srek1ip1", "organism": "Mouse", "refseq_name": "protein SREK1IP1 isoform 1", "refseq_ac": "NP_080351", "gene_names_uniprotkb": "Srek1ip1; Sfrs12ip1", "gene_names_refseq": "3110031B13Rik; Sfrs12ip1; Srek1ip1; Srsf12ip1", "protein_names_uniprotkb": "Protein SREK1IP1; SFRS12-interacting protein 1; SREK1-interacting protein 1", "protein_names_refseq": "SFRS12-interacting protein 1; SREK1-interacting protein 1; protein SFRS12IP1; protein SREK1IP1 isoform 1; protein SREK1IP1; serine/arginine-rich splicing factor 12, interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67288)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Possible splicing regulator involved in the control of cellular survival., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05CD6;Q8CGG6;Q9CRM9;Q9CRR4;Q9CXR0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V9W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64337-1", "uniprot_id": "SQSTM_MOUSE", "mass": 48163.0, "length": 442, "protein_name": "Sequestosome-1", "gene_name": "Sqstm1", "organism": "Mouse", "refseq_name": "sequestosome-1 isoform 2", "refseq_ac": "NP_001277698", "gene_names_uniprotkb": "Sqstm1; A170; STAP", "gene_names_refseq": "A170; OSF-6; Osi; STAP; STONE14; Sqstm1; p62", "protein_names_uniprotkb": "Sequestosome-1; STONE14; Ubiquitin-binding protein p62", "protein_names_refseq": "oxidative stress induced; sequestosome-1 isoform 2; ubiquitin-binding protein p62", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); distal myopathy with rimmed vacuoles (Disease Ontology:DOID:0081363); neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset (Disease Ontology:DOID:0081364); Paget's disease of bone 3 (Disease Ontology:DOID:0081366); frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (Disease Ontology:DOID:0110068); hypertension (Disease Ontology:DOID:10763); glaucoma (Disease Ontology:DOID:1686); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Paget's disease of bone (Disease Ontology:DOID:5408); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:18412); (R-MMU-205043); (R-MMU-209543); (R-MMU-209560); (R-MMU-5205685); (R-MMU-9020702); (R-MMU-9664873); (R-MMU-9755511)", "pathway_count": 8, "publication_count": 43, "publication_id_list": "10.1101/2023.09.13.557529;10458914;11162503;12745069;14960283;15345747;15890008;16075062;16286508;17242355;18382763;18524774;19131326;19144319;20173742;20421418;20495340;21183079;21551061;21750661;22792322;24011591;25040165;25153642;25605945;25723488;26483381;26740625;28055010;28528544;29718959;29843805;33397898;33536919;33875681;34428180;34531248;34887587;37306101;37828378;8806656;9125146;9405250", "class_list": "", "function": "Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:25723488, PubMed:33397898, PubMed:37306101). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:25723488, PubMed:33397898). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:33397898). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:33397898). SQSTM1 is itself degraded along with its ubiquitinated cargos (By similarity). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (By similarity). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (By similarity). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20173742, PubMed:20421418, PubMed:24011591, PubMed:33397898, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (By similarity). May regulate the activation of NFKB1 by TNF, nerve growth factor (NGF) and interleukin-1 (By similarity). May play a role in titin/TTN downstream signaling in muscle cells (By similarity). Adapter that mediates the interaction between TRAF6 and CYLD (PubMed:14960283, PubMed:18382763)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99JM8", "ec_number_list": "", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001659 temperature homeostasis;GO:0001934 positive regulation of protein phosphorylation;GO:0002931 response to ischemia;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q64337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6L8-1", "uniprot_id": "PPIL3_MOUSE", "mass": 18128.0, "length": 161, "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 3", "gene_name": "Ppil3", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase-like 3 isoform 1", "refseq_ac": "NP_001272755", "gene_names_uniprotkb": "Ppil3; Cyp10l", "gene_names_refseq": "2310076N22Rik; 2510026K04Rik; Cyp10l; Ppil3", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase-like 3; 5.2.1.8; CYP10L; Cyclophilin-like protein PPIL3; PPIase; Rotamase PPIL3", "protein_names_refseq": "PPIase; cyclophilin-like 3; cyclophilin-like protein PPIL3; peptidyl-prolyl cis-trans isomerase-like 3 isoform 1; peptidyl-prolyl cis-trans isomerase-like 3; rotamase PPIL3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70225); (R-MMU-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;24129315;25428506", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q812D2;Q9CY23", "ec_number_list": "3.6.4.13;5.2.1.8;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.10;2.3.2.27", "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D6L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60698-1", "uniprot_id": "SKI_MOUSE", "mass": 80119.0, "length": 725, "protein_name": "Ski oncogene", "gene_name": "Ski", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ski", "gene_names_refseq": "", "protein_names_uniprotkb": "Ski oncogene; Proto-oncogene c-Ski", "protein_names_refseq": "", "tax_id": 10090, "disease": "craniosynostosis (Disease Ontology:DOID:2340)", "pathway": " (R-MMU-201451); (R-MMU-2173795)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22645316;23610558;8573720", "class_list": "", "function": "May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIL5", "ec_number_list": "", "go_molecular_function": "GO:0046811 histone deacetylase inhibitor activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0043585 nose morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030326 embryonic limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60698-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61321-1", "uniprot_id": "SIX4_MOUSE", "mass": 82263.0, "length": 775, "protein_name": "Homeobox protein SIX4", "gene_name": "Six4", "organism": "Mouse", "refseq_name": "homeobox protein SIX4 isoform 1", "refseq_ac": "NP_035512", "gene_names_uniprotkb": "Six4; Arec3", "gene_names_refseq": "AREC3; Six4; TrexBF", "protein_names_uniprotkb": "Homeobox protein SIX4; Sine oculis homeobox homolog 4; Skeletal muscle-specific ARE-binding protein AREC3", "protein_names_refseq": "homeobox protein SIX4 isoform 1; homeobox protein SIX4; sine oculis-related homeobox 4 homolog; skeletal muscle-specific ARE-binding protein AREC3", "tax_id": 10090, "disease": "myotonic dystrophy type 1 (Disease Ontology:DOID:11722); branchiootorenal syndrome (Disease Ontology:DOID:14702)", "pathway": " (mmu:20474)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10490620;11313460;12215533;14966291;15788460;15955062;16530750;16938278;17300925;17592144;19027001;19962975;20515681;20696153;21750661;21884692;21978088;23987514;25428506;30084848;31219806;32826305;34203471;34678516;36852467;38920017;8628654;9990334", "class_list": "", "function": "MiR-540-3p partially recovers the locomotor function of spinal cord injury mice by targeting SIX4/Yap1 and inactivation of astrocytes., [RefSeq, PubMed]; Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4alpha and SIX1/4., [RefSeq, PubMed]; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and from a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer (PubMed:14966291). Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein (PubMed:10490620). Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1 (PubMed:15788460). Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6 (PubMed:15788460, PubMed:17592144). Controls somitic differentiation in myocyte through MYOG transactivation (PubMed:15788460). Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3 (PubMed:19962975, PubMed:21884692). Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes (PubMed:21884692). During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression (PubMed:20696153). During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression (PubMed:17300925). Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation (PubMed:23987514). During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation (PubMed:19027001). Promotes survival of sensory neurons during early trigeminal gangliogenesis (PubMed:16938278). In the developing dorsal root ganglia, up-regulates SLC12A2 transcription (PubMed:15955062). Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression (PubMed:16530750). Forms gustatory papillae during development of the tongue (PubMed:21978088). Also plays a role during embryonic cranial skeleton morphogenesis (PubMed:20515681)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RQH3;Q61322;Q61323", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0046661 male sex differentiation;GO:0050678 regulation of epithelial cell proliferation;GO:0061055 myotome development;GO:0061197 fungiform papilla morphogenesis;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q61321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63328-1", "uniprot_id": "PP2BA_MOUSE", "mass": 58644.0, "length": 521, "protein_name": "Protein phosphatase 3 catalytic subunit alpha", "gene_name": "Ppp3ca", "organism": "Mouse", "refseq_name": "protein phosphatase 3 catalytic subunit alpha isoform 2", "refseq_ac": "NP_001280551", "gene_names_uniprotkb": "Ppp3ca; Calna", "gene_names_refseq": "2900074D19Rik; CN; Calna; Caln; CnA; Ppp3ca", "protein_names_uniprotkb": "Protein phosphatase 3 catalytic subunit alpha; 3.1.3.16; CAM-PRP catalytic subunit; CNA alpha; Calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform", "protein_names_refseq": "CAM-PRP catalytic subunit; CNA alpha; PP2B alpha 1; PP2BA alpha; calcineurin A alpha; protein phosphatase 3 catalytic subunit alpha isoform 2; protein phosphatase 3 catalytic subunit alpha", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:19055); (R-MMU-2025928); (R-MMU-2871809); (R-MMU-4086398); (R-MMU-5607763)", "pathway_count": 5, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10200317;11114196;12773574;12809556;15509543;16286645;16735444;16800626;16968888;17114649;19626032;20639889;21183079;21427212;21435446;2162844;25428506;26029823;26794871;2848250;29187734;30084848;30611118;31696965;32152506;32910282;33300544;34428180;34678516;36206766;36974338;7791792;8077208;8627154", "class_list": "", "function": "Calcineurin dephosphorylates topoisomerase IIbeta and regulates the formation of neuronal-activity-induced DNA breaks., [RefSeq, PubMed]; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:26794871, PubMed:7791792). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (PubMed:15509543). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (PubMed:16735444). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (PubMed:21435446). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (PubMed:10200317). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (PubMed:19626032). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (PubMed:16286645). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (PubMed:16968888). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (PubMed:12773574). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (PubMed:26029823). Required for antigen-specific T-cell proliferation response (PubMed:8627154). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (By similarity). Negatively regulates SLC9A1 activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RRX2;P12816;P20652;Q3UCU1;Q64135", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0016311 dephosphorylation;GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress;GO:1905205 positive regulation of connective tissue replacement;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P63328-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TDD9-1", "uniprot_id": "PPR21_MOUSE", "mass": 88338.0, "length": 780, "protein_name": "Protein phosphatase 1 regulatory subunit 21", "gene_name": "Ppp1r21", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 21", "refseq_ac": "NP_082934", "gene_names_uniprotkb": "Ppp1r21; Ccdc128; Klraq1", "gene_names_refseq": "1110018J12Rik; Ccdc128; Fy-2; Klraq1; Ppp1r21", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 21; Coiled-coil domain-containing protein 128; Ferry endosomal RAB5 effector complex subunit 2; Fy-2; KLRAQ motif-containing protein 1", "protein_names_refseq": "KLRAQ motif containing 1; KLRAQ motif-containing protein 1; coiled-coil domain containing 128; coiled-coil domain-containing protein 128; ferry endosomal RAB5 effector complex subunit 2; protein phosphatase 1 regulatory subunit 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:73825)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21183079;22872234;25428506;25605945;30084848;30520571;31219806;34428180;40684658", "class_list": "", "function": "Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction. In the complex, PPP1R21 serves as a binding hub connecting all five complex subunits and mediating the binding to mRNA and early endosomes via RAB5A (By similarity). Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RPZ6;Q3KQN7;Q3U2U9;Q8BHS9;Q9D1A1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0016020 membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:1904580 regulation of intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3TDD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60636-1", "uniprot_id": "PRDM1_MOUSE", "mass": 95836.0, "length": 856, "protein_name": "PR domain zinc finger protein 1", "gene_name": "Prdm1", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 1 isoform 4", "refseq_ac": "NP_031574", "gene_names_uniprotkb": "Prdm1; Blimp1", "gene_names_refseq": "Blimp-1; Blimp1; PRDI-BF1; Prdm1; ZNFPR1A1; b2b1765Clo", "protein_names_uniprotkb": "PR domain zinc finger protein 1; 2.1.1.-; B lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; Blimp-1; PR domain-containing protein 1", "protein_names_refseq": "B lymphocyte induced maturation protein; B lymphocyte-induced maturation protein 1; PR domain zinc finger protein 1 isoform 4; PR domain zinc finger protein 1; PR domain-containing protein 1; beta-interferon gene positive regulatory domain I-binding factor", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); lung cancer (Disease Ontology:DOID:1324); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12142)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11121475;16699504;19737919;22733990;25428506;27102484;30779550;32741026;34428180;8168136", "class_list": "", "function": "Alternative splicing regulates Blimp-1 recruitment of corepressors and DNA binding activity., [RefSeq, PubMed]; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed:32741026)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2VDE8;Q3UET9", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0003170 heart valve development;GO:0032823 regulation of natural killer cell differentiation;GO:0033082 regulation of extrathymic T cell differentiation;GO:0051136 regulation of NK T cell differentiation;GO:1990654 sebum secreting cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60636-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KR7-1", "uniprot_id": "PPIF_MOUSE", "mass": 21737.0, "length": 206, "protein_name": "Peptidyl-prolyl cis-trans isomerase F, mitochondrial", "gene_name": "Ppif", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor", "refseq_ac": "NP_598845", "gene_names_uniprotkb": "Ppif", "gene_names_refseq": "CyP-D; CyP-F; CypD; PPIase; Ppif", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase F, mitochondrial; 5.2.1.8; CyP-D; Cyclophilin D; Cyclophilin F; CypD; PPIase F; Rotamase F", "protein_names_refseq": "PPIase F; cyclophilin D; cyclophilin F; mitochondrial Cyclophilin D; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor; peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; rotamase F", "tax_id": 10090, "disease": "", "pathway": " (mmu:105675)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;15792954;15800626;15800627;16103352;18684715;19801635;20950273;21212461;21281446;21930693;22726440;23576753;23806337;31489369;36288343;37507081;39299628", "class_list": "", "function": "Cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death, [RefSeq, PubMed]; Cyclophilin D, regulator of the mitochondrial permeability transition, impacts bone development and fracture repair., [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (By similarity). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:15800626, PubMed:15800627, PubMed:16103352, PubMed:18684715, PubMed:31489369). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:15800626, PubMed:15800627, PubMed:16103352, PubMed:18684715, PubMed:31489369). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (PubMed:19801635, PubMed:21281446). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Results indicate that the CypD-dependent mitochondrial permeability transition regulates some forms of necrotic death, but not apoptotic death, [RefSeq, PubMed]; The permeability transition pore can form and open in the absence of CyP-D, which is the target for PTP inhibition by Cyclosporin A, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042277 peptide binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death;GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q99KR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES83-1", "uniprot_id": "POPD1_MOUSE", "mass": 41016.0, "length": 358, "protein_name": "Popeye domain-containing protein 1", "gene_name": "Popdc1", "organism": "Mouse", "refseq_name": "popeye domain-containing protein 1 isoform a", "refseq_ac": "NP_077247", "gene_names_uniprotkb": "Popdc1; Bves; Pop1", "gene_names_refseq": "Bves; Pop1; Popdc1; mBVES", "protein_names_uniprotkb": "Popeye domain-containing protein 1; Blood vessel epicardial substance; Popeye protein 1; mBVES", "protein_names_refseq": "blood vessel epicardial substance; popeye 1; popeye domain-containing protein 1 isoform a; popeye domain-containing protein 1; popeye protein 1", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2X (Disease Ontology:DOID:0110290); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:23828)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10208750;10882522;11839816;16188940;18541910;20057356;21183079;22354168;24066022;26642364;36288343", "class_list": "", "function": "Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3 (PubMed:20057356). Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT (PubMed:18541910). Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (PubMed:11839816). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (PubMed:24066022)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2RS91;Q8C8L3", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0030054 cell junction;GO:0005901 caveola", "go_biological_process": "GO:0060931 sinoatrial node cell development;GO:0002931 response to ischemia;GO:0007507 heart development;GO:0042391 regulation of membrane potential;GO:0043087 regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9ES83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUG3-1", "uniprot_id": "PRND_MOUSE", "mass": 20442.0, "length": 179, "protein_name": "Prion-like protein doppel", "gene_name": "Prnd", "organism": "Mouse", "refseq_name": "prion-like protein doppel precursor", "refseq_ac": "NP_001119810", "gene_names_uniprotkb": "Prnd", "gene_names_refseq": "Dpl; PrPLP; Prnd; doppel", "protein_names_uniprotkb": "Prion-like protein doppel; Doppelganger; Dpl; PrPLP", "protein_names_refseq": "doppelganger; prion protein dublet; prion protein-like protein; prion-like protein doppel precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:26434); (R-MMU-163125)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10525406;10842180;10930132;11226243;12110578;15007175;15161660;16388591;24286250;24339999", "class_list": "", "function": "Data suggest that glycosylation status of the prion protein and yet-to-be-identified proteases modulate internal C1 and C2 endoproteolysis of Doppel (doppelganger prion) and Shadoo (shadow of prion protein) in mouse neurons., [RefSeq, PubMed]; In GC-1 spg cells, phosphorylation of p21 and N-terminal truncated PrP may play roles in the control of Dpl-induced apoptosis, which may benefit the physiological function of Dpl in the male reproduction system. Publication Status: Online-Only, [RefSeq, PubMed]; Required for normal acrosome reaction and for normal male fertility (PubMed:12110578, PubMed:15007175, PubMed:15161660). Can bind Cu(2+) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZT5", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0051260 protein homooligomerization;GO:0007338 single fertilization;GO:0007340 acrosome reaction;GO:0071280 cellular response to copper ion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QUG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60674-1", "uniprot_id": "NR1D2_MOUSE", "mass": 64302.0, "length": 576, "protein_name": "Nuclear receptor subfamily 1 group D member 2", "gene_name": "Nr1d2", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 1 group D member 2 isoform 1", "refseq_ac": "NP_035714", "gene_names_uniprotkb": "Nr1d2", "gene_names_refseq": "Nr1d2; RVR; Rev-erb", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group D member 2; Orphan nuclear receptor RVR; Rev-erb-beta", "protein_names_refseq": "Rev-erb beta; nuclear receptor subfamily 1 group D member 2 isoform 1; orphan nuclear receptor RVR; rev-erb-beta", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651)", "pathway": " (mmu:353187); (R-MMU-383280)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "15623503;18454201;19682428;21750661;22474260;23221024;23728303;25428506;29355503;29508494;29533925;29723273;30084848;34428180;38142970;7838156;7838158", "class_list": "", "function": "Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology., [RefSeq, PubMed]; This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle. Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (PubMed:29355503). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (PubMed:29723273). May play a role in the circadian control of neutrophilic inflammation in the lung (PubMed:29533925)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60646", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q60674-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LH1-1", "uniprot_id": "NOG2_MOUSE", "mass": 83345.0, "length": 728, "protein_name": "Nucleolar GTP-binding protein 2", "gene_name": "Gnl2", "organism": "Mouse", "refseq_name": "nucleolar GTP-binding protein 2", "refseq_ac": "NP_663527", "gene_names_uniprotkb": "Gnl2", "gene_names_refseq": "Gnl2; HUMAUANTIG; Ngp-1", "protein_names_uniprotkb": "Nucleolar GTP-binding protein 2", "protein_names_refseq": "guanine nucleotide binding protein-like 2 (nucleolar); nucleolar GTP-binding protein 2; testicular antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:230737)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20173027;21183079;21750661;34203471;34418053;36852467", "class_list": "", "function": "GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ASC3;Q8BIF8", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99LH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Y57-1", "uniprot_id": "SIG12_MOUSE", "mass": 51901.0, "length": 467, "protein_name": "Sialic acid-binding Ig-like lectin 12", "gene_name": "Siglec12; Siglece", "organism": "Mouse", "refseq_name": "sialic acid-binding Ig-like lectin 12 precursor", "refseq_ac": "NP_112458", "gene_names_uniprotkb": "Siglec12; Siglece; Siglec5; Siglece; Siglecl1", "gene_names_refseq": "Cd170; Siglec12; Siglec5; Siglec9; Siglece; Siglecl1; mSiglec-E", "protein_names_uniprotkb": "Sialic acid-binding Ig-like lectin 12; MIS; Myeloid inhibitory siglec; Sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin E; Sialic acid-binding Ig-like lectin-like 1; Siglec-12; Siglec-5; Siglec-E; Siglec-L1; mSiglec-E", "protein_names_refseq": "MIS; SIGLEC-like 1; myeloid inhibitory siglec; sialic acid binding Ig-like lectin 5; sialic acid-binding Ig-like lectin 12 precursor; sialic acid-binding Ig-like lectin 12; sialic acid-binding Ig-like lectin-like 1; sialic acid-binding immunoglobulin-like lectin E; siglec-12; siglec-5; siglec-E; siglec-L1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83382); (R-MMU-198933); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11171044;11278955;21750661;30084848;30779550;34428180;38454157;38990656", "class_list": "glycogene", "function": "Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers. Publication Status: Online-Only, [RefSeq, PubMed]; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules., [UniProtKB]; The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "E9QMD1", "ec_number_list": "", "go_molecular_function": "GO:0033691 sialic acid binding;GO:0048029 monosaccharide binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91Y57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z179-1", "uniprot_id": "SHCBP_MOUSE", "mass": 75917.0, "length": 668, "protein_name": "SHC SH2 domain-binding protein 1", "gene_name": "Shcbp1", "organism": "Mouse", "refseq_name": "SHC SH2 domain-binding protein 1", "refseq_ac": "NP_035499", "gene_names_uniprotkb": "Shcbp1; Pal", "gene_names_refseq": "Shcbp1; mPAL", "protein_names_uniprotkb": "SHC SH2 domain-binding protein 1; Protein expressed in activated lymphocytes; SHC-binding protein; mPAL", "protein_names_refseq": "SHC SH2 domain-binding protein 1; SHC-binding protein; protein expressed in activated lymphocytes", "tax_id": 10090, "disease": "", "pathway": " (mmu:20419)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10086341;21750661;22508726;25428506;25605945;30084848;31219806;38169303;38215233", "class_list": "", "function": "Knockout of Shcbp1 sensitizes immunotherapy by regulating alpha-SMA positive cancer-associated fibroblasts., [RefSeq, PubMed]; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells., [UniProtKB, PubMed, PubMed]; SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UED9;Q3UMD9", "ec_number_list": "", "go_molecular_function": "GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0030496 midbody;GO:0072686 mitotic spindle;GO:0005819 spindle", "go_biological_process": "GO:0008543 fibroblast growth factor receptor signaling pathway;GO:2000177 regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z179-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ALU4-1", "uniprot_id": "SHRM2_MOUSE", "mass": 164703.0, "length": 1481, "protein_name": "Protein Shroom2", "gene_name": "Shroom2", "organism": "Mouse", "refseq_name": "protein Shroom2 isoform 2", "refseq_ac": "NP_001277613", "gene_names_uniprotkb": "Shroom2; Apxl", "gene_names_refseq": "4832440C16; Apxl; C630003H05Rik; Shrm2; Shroom2", "protein_names_uniprotkb": "Protein Shroom2; Protein Apxl", "protein_names_refseq": "protein Shroom2 isoform 2; protein Shroom2", "tax_id": 10090, "disease": "", "pathway": " (mmu:110380)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16615870;16684770;16987870;17242355;17666436;21183079;21248203;31219806;34428180", "class_list": "", "function": "Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis., [RefSeq, PubMed]; May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution., [UniProtKB, PubMed, PubMed]; Shroom2 and ZO-1 form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa, that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q2EY23;Q8C7N1;Q8CCR2;Q8CDZ0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0051015 actin filament binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0008057 eye pigment granule organization;GO:0043482 cellular pigment accumulation;GO:0007015 actin filament organization;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "A2ALU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q942-1", "uniprot_id": "SIM13_MOUSE", "mass": 9954.0, "length": 88, "protein_name": "Small integral membrane protein 13", "gene_name": "Smim13", "organism": "Mouse", "refseq_name": "small integral membrane protein 13", "refseq_ac": "NP_001129049", "gene_names_uniprotkb": "Smim13", "gene_names_refseq": "2900036K02Rik; Smim13", "protein_names_uniprotkb": "Small integral membrane protein 13", "protein_names_refseq": "UPF0766 protein C6orf228 homolog; small integral membrane protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:108934)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q942-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35182-1", "uniprot_id": "SMAD6_MOUSE", "mass": 53714.0, "length": 495, "protein_name": "SMAD family member 6", "gene_name": "Smad6", "organism": "Mouse", "refseq_name": "SMAD family member 6", "refseq_ac": "NP_032568", "gene_names_uniprotkb": "Smad6; Madh6; Madh7; Msmad6", "gene_names_refseq": "Madh6; Smad6; b2b390Clo", "protein_names_uniprotkb": "SMAD family member 6; MAD homolog 6; Mad homolog 7; Mothers against DPP homolog 6; Mothers against decapentaplegic homolog 6; SMAD 6", "protein_names_refseq": "MAD homolog 6; SMAD family member 6; Smad 6; mad homolog 7; mothers against DPP homolog 6; mothers against decapentaplegic homolog 6", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); craniosynostosis 7 (Disease Ontology:DOID:0060912); aortic valve disease 2 (Disease Ontology:DOID:0080334); nephritis (Disease Ontology:DOID:10952); pulmonary hypertension (Disease Ontology:DOID:6432); radioulnar synostosis (Disease Ontology:DOID:9827)", "pathway": " (mmu:17130); (R-MMU-201451)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14657019;15221015;15496141;16951688;21750661;21897371;23610558;23747011;9335505", "class_list": "", "function": "Acts as an inhibitory regulator of signaling mediated by the TGF-beta superfamily, with strong selectivity toward BMP-dependent pathways. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear translocation and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Associates with regulatory elements in target promoter regions. Functions as an adapter protein that recruits ubiquitin ligases, including SMURF1 and, in some contexts, SMURF2, promoting proteasomal degradation of signaling components and transcription factors such as RUNX2, TBX6, BMPR1A and MYD88., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW62", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0003170 heart valve development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08228-1", "uniprot_id": "SODC_MOUSE", "mass": 15943.0, "length": 154, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "Sod1", "organism": "Mouse", "refseq_name": "superoxide dismutase [Cu-Zn]", "refseq_ac": "NP_035564", "gene_names_uniprotkb": "Sod1", "gene_names_refseq": "B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1; Ipo1; SODC; Sod-1; Sod1", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; 1.8.-.-; Hydrogen sulfide oxidase", "protein_names_refseq": "Cu(2+)-Zn2+ superoxide dismutase; hydrogen sulfide oxidase; superoxide dismutase [Cu-Zn]", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dry eye syndrome (Disease Ontology:DOID:10140); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); renal artery obstruction (Disease Ontology:DOID:2972); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); nutritional deficiency disease (Disease Ontology:DOID:5113); myocardial infarction (Disease Ontology:DOID:5844); prion disease (Disease Ontology:DOID:649); progressive supranuclear palsy (Disease Ontology:DOID:678); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20655); (R-MMU-114608); (R-MMU-3299685)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;16075062;2022332;20727846;21183079;21420488;22203986;22872234;23576753;23806337;2391363;29194436;3362683;34428180;37453647;39927985", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 41, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.15.1.1;1.8.-.-;3.6.4.-;3.6.5.-;3.1.30.-;1.11.1.-;1.7.-.-;1.14.12.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0034465 response to carbon monoxide;GO:0008090 retrograde axonal transport;GO:0000303 response to superoxide;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P08228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70340-1", "uniprot_id": "SMAD1_MOUSE", "mass": 52157.0, "length": 465, "protein_name": "SMAD family member 1", "gene_name": "Smad1", "organism": "Mouse", "refseq_name": "SMAD family member 1", "refseq_ac": "NP_032565", "gene_names_uniprotkb": "Smad1; Madh1; Madr1", "gene_names_refseq": "Mad1; Madh1; Madr1; Mlp1; MusMLP; Smad1; dwf-A; mMad1", "protein_names_uniprotkb": "SMAD family member 1; Dwarfin-A; Dwf-A; MAD homolog 1; Mad-related protein 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; Mothers-against-DPP-related 1; SMAD 1; mMad1", "protein_names_refseq": "MAD homolog 1; SMAD family member 1; dwarfin-A; mad-related protein 1; mothers against DPP homolog 1; mothers against decapentaplegic homolog 1; mothers-against-DPP-related 1", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); nephrotic syndrome (Disease Ontology:DOID:1184); male infertility (Disease Ontology:DOID:12336); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:17125); (R-MMU-201451); (R-MMU-5689880); (R-MMU-8941326)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10504300;11094085;11111041;11566864;12151307;12370310;15329343;16115198;16801560;18160706;19536134;19821774;20147459;21239498;21420501;24126843;25755279;34995814;35594155;8799132;9076678;9748228", "class_list": "", "function": "Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:11566864, PubMed:15329343, PubMed:21420501, PubMed:35594155). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (PubMed:34995814)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70442;Q6GT95;Q9CYK6", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002051 osteoblast fate commitment;GO:1903672 positive regulation of sprouting angiogenesis;GO:0001710 mesodermal cell fate commitment;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P70340-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5S003-1", "uniprot_id": "SPG17_MOUSE", "mass": 263102.0, "length": 2320, "protein_name": "Sperm-associated antigen 17", "gene_name": "Spag17", "organism": "Mouse", "refseq_name": "sperm-associated antigen 17", "refseq_ac": "NP_083168", "gene_names_uniprotkb": "Spag17", "gene_names_refseq": "4931427F14Rik; PF6; Spag17-ps; Spag17", "protein_names_uniprotkb": "Sperm-associated antigen 17; Projection protein PF6 homolog", "protein_names_refseq": "projection protein PF6 homolog; sperm associated antigen 17, pseudogene; sperm-associated antigen 17", "tax_id": 10090, "disease": "spermatogenic failure 55 (Disease Ontology:DOID:0112337)", "pathway": " (mmu:74362)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15827353;23418344;26017218;29690537;30059200;30084848;32988999", "class_list": "", "function": "A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice. Erratum:[Dis Model Mech. 2021 Jan 1;14(1):dmm048645. doi: 10.1242/dmm.048645. PMID: 34115122] Publication Status: Online-Only, [RefSeq, PubMed]; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia (PubMed:15827353, PubMed:23418344). May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts (PubMed:26017218). Essential for normal spermatogenesis and male fertility (PubMed:29690537). Required for normal manchette structure, transport of proteins along the manchette microtubules and formation of the sperm head and flagellum (PubMed:29690537). Essential for sperm flagellum development and proper assembly of the respiratory motile cilia central pair apparatus, but not the brain ependymal cilia (PubMed:32988999)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Deletion of Spag17 gene expression results in hydrocephalus and pulmonary and nasal mucus and fluid congestion., [RefSeq, PubMed]; Spag17 plays a role in skeletal growth and mineralization.Spag17 deficiency results in skeletal malformations and bone abnormalities. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3UYF7;Q3UWG8;Q6Q758;Q8CDR5;Q9CUE5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule", "go_biological_process": "GO:1904158 axonemal central apparatus assembly;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007283 spermatogenesis;GO:0044458 motile cilium assembly;GO:1905198 manchette assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5S003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62232-1", "uniprot_id": "SIX2_MOUSE", "mass": 32718.0, "length": 296, "protein_name": "Homeobox protein SIX2", "gene_name": "Six2", "organism": "Mouse", "refseq_name": "homeobox protein SIX2", "refseq_ac": "NP_035510", "gene_names_uniprotkb": "Six2", "gene_names_refseq": "Six2", "protein_names_uniprotkb": "Homeobox protein SIX2; Sine oculis homeobox homolog 2", "protein_names_refseq": "homeobox protein SIX2; sine oculis homeobox homolog 2; sine oculis-related homeobox 2 homolog", "tax_id": 10090, "disease": "renal Wilms' tumor (Disease Ontology:DOID:5176); cleft palate (Disease Ontology:DOID:674); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:20472)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11734542;12215533;17036046;18321982;18682239;19660448;19716816;20515681;21350016;22902740;24598167;7720577;8814301", "class_list": "", "function": "Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681). During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448). During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982). May also be involved in limb tendon and ligament development (PubMed:7720577). Plays a role in cell proliferation and migration (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70179", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008134 transcription factor binding;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0072006 nephron development;GO:0072137 condensed mesenchymal cell proliferation;GO:0007501 mesodermal cell fate specification;GO:0072028 nephron morphogenesis;GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4D1-1", "uniprot_id": "SL9A8_MOUSE", "mass": 64737.0, "length": 576, "protein_name": "Sodium/hydrogen exchanger 8", "gene_name": "Slc9a8", "organism": "Mouse", "refseq_name": "sodium/hydrogen exchanger 8 isoform c", "refseq_ac": "NP_001291469", "gene_names_uniprotkb": "Slc9a8; Nhe8", "gene_names_refseq": "1200006P13Rik; 6430709P13Rik; NHE-8; NHE8; Slc9a8", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 8; NHE-8; Na(+)/H(+) exchanger 8; Solute carrier family 9 member 8", "protein_names_refseq": "Na(+)/H(+) exchanger 8; sodium/hydrogen exchanger 8 isoform c; sodium/hydrogen exchanger 8; sodium/proton exchanger NHE8", "tax_id": 10090, "disease": "", "pathway": " (mmu:77031); (R-MMU-425986)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;12409279;14702039;15522866;18209477;21183079;21252044;21750661;22575219;23220221;23657568;25377091;25428506;25472965;25605945;26505975;26740625;28476888;29958869;30084848;31042050;32755385;34428180", "class_list": "", "function": "An indisputable role of NHE8 in mucosal protection., [RefSeq, PubMed]; Has >50% identity to Drosophila melanogaster 'NHE1,'; NHE8 is expressed in the proximal kidney tubule, where it may contribute to apical membrane ion transport, [RefSeq, PubMed]; Intestinal NHE8 has a compensatory role in NHE2X3 DKO mice and this regulation is gender-dependent., [RefSeq, PubMed]; NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms., [RefSeq, PubMed]; NHE8 regulates Ca(2+) uptake into the proximal tubule epithelium., [RefSeq, PubMed]; Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity). Plays a crucial role in germ cells in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (PubMed:25472965, PubMed:28476888). Can also be active at the cell surface of specialized cells. In the small intestine, plays a major physiological role in transepithelial absorption of Na(+). Regulates intracellular pH homeostasis of intestinal epithelial cells (By similarity). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (PubMed:23220221, PubMed:23657568, PubMed:26505975). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (PubMed:25377091, PubMed:29958869)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The role of NHE8 in the intestine involves both sodium absorption and bicarbonate secretion, [RefSeq, PubMed]; This gene encodes a member of the Na+/H+ exchanger (NHE) family of integral membrane transporter proteins. The encoded protein is expressed on the apical membrane of the intestinal epithelial cells and plays an important role in mucosal protection. Loss of the encoded protein in mice results in a decrease in the number of goblet and mucin-positive cells, disorganization of the mucin layer, and a decrease in mucosal pH in the colon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A465;Q3UPR4;Q5WA59;Q8BIH8;Q8BJ27", "ec_number_list": "", "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006813 potassium ion transport;GO:0035725 sodium ion transmembrane transport;GO:0001675 acrosome assembly;GO:0006814 sodium ion transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8R4D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J77-1", "uniprot_id": "SIAS_MOUSE", "mass": 40024.0, "length": 359, "protein_name": "N-acetylneuraminate-9-phosphate synthase", "gene_name": "Nans", "organism": "Mouse", "refseq_name": "N-acetylneuraminate-9-phosphate synthase isoform 1", "refseq_ac": "NP_444409", "gene_names_uniprotkb": "Nans; Sas", "gene_names_refseq": "4632418E04Rik; Nans; Sas", "protein_names_uniprotkb": "N-acetylneuraminate-9-phosphate synthase; 2.5.1.57; N-acetylneuraminic acid phosphate synthase; Sialic acid synthase", "protein_names_refseq": "N-acetylneuraminate-9-phosphate synthase isoform 1; N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid 9-phosphate synthetase; N-acetylneuraminic acid phosphate synthase; sialic acid synthase", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia, Genevieve-type (Disease Ontology:DOID:0080576)", "pathway": " (mmu:94181); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10873658;17292865;21183079;23806337;28528544;34428180", "class_list": "glycogene", "function": "Catalyzes condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10873658). Neu5Ac-9-P is the phosphorylated forms of sialic acid N-acetylneuraminic acid (Neu5Ac) (PubMed:10873658). In contrast with human ortholog, has no detectable activity towards D-mannose 6-phosphate (PubMed:10873658)., [UniProtKB, PubMed]; Intracellular localization of this enzyme is regulated not only due to the nuclear localization signal but also two nuclear export signals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJH0", "ec_number_list": "2.5.1.57", "go_molecular_function": "GO:0047444 N-acylneuraminate-9-phosphate synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process;GO:0046380 N-acetylneuraminate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99J77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0K7-1", "uniprot_id": "SLUR1_MOUSE", "mass": 12016.0, "length": 110, "protein_name": "Secreted Ly-6/uPAR-related protein 1", "gene_name": "Slurp1", "organism": "Mouse", "refseq_name": "secreted Ly-6/uPAR-related protein 1 precursor", "refseq_ac": "NP_065265", "gene_names_uniprotkb": "Slurp1; Ars", "gene_names_refseq": "1110021N19Rik; ARS; ArsB; Slurp-1; Slurp1", "protein_names_uniprotkb": "Secreted Ly-6/uPAR-related protein 1; ARS component B; SLURP-1", "protein_names_refseq": "Ars component B; secreted Ly-6/uPAR-related protein 1 precursor; secreted Ly-6/uPAR-related protein 1", "tax_id": 10090, "disease": "mal de Meleda (Disease Ontology:DOID:0060862); palmoplantar keratosis (Disease Ontology:DOID:3390)", "pathway": " (mmu:57277)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14721776;17286989;19396877;20621062;21750661;23139280;24499735;25168896;34721415;34923162;38866482", "class_list": "", "function": "Endogenous alpha7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier. Publication Status: Online-Only, [RefSeq, PubMed]; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (By similarity). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:23139280, PubMed:25168896)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma. Publication Status: Online-Only, [RefSeq, PubMed]; Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression., [RefSeq, PubMed]; Slurp1 in mice has a role in neuromuscular and metabolic phenotypes in addition to its role in palmoplantar keratoderma, [RefSeq, PubMed]; Those findings suggest that diminished expression of SLURP-1 in asthma attenuates its negative regulation of airway inflammation, and that perhaps changes in SLURP-1 expression could serve as a marker of airway damage in asthma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TA55", "ec_number_list": "", "go_molecular_function": "GO:0030549 acetylcholine receptor activator activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038195 urokinase plasminogen activator signaling pathway;GO:0007626 locomotory behavior;GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:0010839 negative regulation of keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z0K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7V1-1", "uniprot_id": "SH24A_MOUSE", "mass": 48460.0, "length": 421, "protein_name": "SH2 domain-containing protein 4A", "gene_name": "Sh2d4a", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 4A", "refseq_ac": "NP_082458", "gene_names_uniprotkb": "Sh2d4a", "gene_names_refseq": "2210402M20Rik; SH2A; Sh2d4a", "protein_names_uniprotkb": "SH2 domain-containing protein 4A", "protein_names_refseq": "SH2 domain-containing protein 4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:72281)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17251388;18641339;21183079;21750661;30084848;34428180;35820727;36852467;40885482", "class_list": "", "function": "Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function., [UniProtKB, PubMed]; SH2D4A is dispensable for TCR signal transduction in T cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q14AV2", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D7V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZW3-1", "uniprot_id": "SMCA5_MOUSE", "mass": 121627.0, "length": 1051, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "gene_name": "Smarca5", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "refseq_ac": "NP_444354", "gene_names_uniprotkb": "Smarca5; Snf2h", "gene_names_refseq": "4933427E24Rik; D030040M08Rik; D330027N15Rik; MommeD4; Smarca5; Snf2h", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; 3.6.4.-; SMARCA5; Sucrose nonfermenting protein 2 homolog; mSnf2h", "protein_names_refseq": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; mSnf2h; sucrose nonfermenting protein 2 homolog", "tax_id": 10090, "disease": "central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:93762); (R-MMU-5250924); (R-MMU-5693565); (R-MMU-606279)", "pathway_count": 4, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10914549;11359880;11532953;11980720;12198165;12368916;14617767;15284901;16514417;17242355;19092802;19144319;21183079;22872234;23806337;25428506;25605945;31219806;34197713;34428180;34887587;37507081;38776924;39060657;39627609", "class_list": "", "function": "ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (By similarity). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:11532953, PubMed:11980720, PubMed:12198165). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:11532953, PubMed:11980720, PubMed:12198165). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (By similarity). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:11532953, PubMed:11980720, PubMed:12198165). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (By similarity). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (By similarity). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (PubMed:12198165). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (PubMed:19092802). Essential component of the NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (PubMed:11532953, PubMed:12198165, PubMed:12368916). Required for embryonic development and differentiation, and the proliferation of early blastocyst-derived stem cells (PubMed:14617767)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice., [RefSeq, PubMed]; SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C791;Q8CA22;Q8VDG1;Q925M9", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;2.3.1.48;2.3.1.-;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;3.5.1.-;3.5.1.98;2.7.7.6;7.6.2.1;3.6.1.5;2.1.1.37;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;2.3.1.57;2.7.11.26;2.7.10.2", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q91ZW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZS8-1", "uniprot_id": "SH2D3_MOUSE", "mass": 94323.0, "length": 854, "protein_name": "SH2 domain-containing protein 3C", "gene_name": "Sh2d3c", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 3C isoform 2", "refseq_ac": "NP_001239476", "gene_names_uniprotkb": "Sh2d3c; Chat; Shep1", "gene_names_refseq": "Chat; Nsp3; Sh2d3c; Shep1", "protein_names_uniprotkb": "SH2 domain-containing protein 3C; Cas/HEF1-associated signal transducer; SH2 domain-containing Eph receptor-binding protein 1", "protein_names_refseq": "Cas/HEF1-associated signal transducer; SH2 domain-containing Eph receptor-binding protein 1; SH2 domain-containing protein 3C isoform 2; SH2 domain-containing protein 3C; novel SH2-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:27387)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10542222;10692442;12486027;15272013;17174122;19144319;20505138;20603213;20881139;20956287;21183079;22517741;22645316;26495903;27417580;32848054;34428180;40885482", "class_list": "", "function": "Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:20505138, PubMed:20881139, PubMed:20956287). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (By similarity). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (PubMed:20505138, PubMed:20956287). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (PubMed:20505138). Plays a role in CXCL13-induced chemotaxis of B-cells (PubMed:20505138, PubMed:20956287). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (PubMed:20881139). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (PubMed:20881139)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Chat-H regulates atherosclerosis development by controlling monocyte adhesion and recruitment to the plaques., [RefSeq, PubMed]; Glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal growth factor (EGF), implying that these activities of SHEP1 depend upon a physical interaction with Cas, [RefSeq, PubMed]; Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (PubMed:17174122). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (PubMed:17174122). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (PubMed:17174122). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (PubMed:12486027)., [UniProtKB, PubMed, PubMed]; May be involved in the BCAR1/CAS-mediated JNK activation pathway., [UniProtKB, PubMed]; SHEP1 and CasL are constitutively associated in B cells., [RefSeq, PubMed]; Shep1 plays a critical role in the in vivo regulation of Src activity and Cas downstream signaling through Crk protein., [RefSeq, PubMed]; Shep1 plays an important role in the early ingrowth of peripheral olfactory sensory axons into the forebrain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2AK84;Q9JME1", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9QZS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPD1-1", "uniprot_id": "FBX11_MOUSE", "mass": 103728.0, "length": 930, "protein_name": "F-box only protein 11", "gene_name": "Fbxo11", "organism": "Mouse", "refseq_name": "F-box only protein 11 isoform 1", "refseq_ac": "NP_001074503", "gene_names_uniprotkb": "Fbxo11", "gene_names_refseq": "Fbxo11; Jf", "protein_names_uniprotkb": "F-box only protein 11", "protein_names_refseq": "F-box only protein 11 isoform 1; F-box only protein 11", "tax_id": 10090, "disease": "intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (Disease Ontology:DOID:0061129); stomach cancer (Disease Ontology:DOID:10534); otitis media (Disease Ontology:DOID:10754); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:225055); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12943368;17035249;21750661;22872234;25827072;31219806;34428180;36863499;37279268", "class_list": "", "function": "FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA., [RefSeq, PubMed]; FBXO11 regulates bone development., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:25827072). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (By similarity). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (By similarity). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (By similarity). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (By similarity). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (By similarity). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (By similarity). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (By similarity). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (By similarity). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A595;E9QP06;Q08EB9;Q08EC0;Q80UP0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0007605 sensory perception of sound;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TPD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35304-1", "uniprot_id": "VACHT_MOUSE", "mass": 56615.0, "length": 530, "protein_name": "Vesicular acetylcholine transporter", "gene_name": "Slc18a3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slc18a3; Vacht", "gene_names_refseq": "", "protein_names_uniprotkb": "Vesicular acetylcholine transporter; Solute carrier family 18 member 3; VAChT", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital myasthenic syndrome 21 (Disease Ontology:DOID:0110672); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); asthma (Disease Ontology:DOID:2841); bladder disease (Disease Ontology:DOID:365)", "pathway": " (R-MMU-264642); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17092608;19635813;23045697;25428506;9427309", "class_list": "", "function": "Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (By similarity). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity) (PubMed:19635813). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (PubMed:23045697). Can transport serotonin., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008504 monoamine transmembrane transporter activity;GO:0005277 acetylcholine transmembrane transporter activity;GO:0015311 monoamine:proton antiporter activity;GO:0005278 acetylcholine:proton antiporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0043679 axon terminus", "go_biological_process": "GO:0015870 acetylcholine transport;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0007268 chemical synaptic transmission;GO:0014057 positive regulation of acetylcholine secretion, neurotransmission;GO:0051610 serotonin uptake", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35304-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60932-1", "uniprot_id": "VDAC1_MOUSE", "mass": 32351.0, "length": 296, "protein_name": "Non-selective voltage-gated ion channel VDAC1", "gene_name": "Vdac1", "organism": "Mouse", "refseq_name": "non-selective voltage-gated ion channel VDAC1 isoform 2", "refseq_ac": "NP_035824", "gene_names_uniprotkb": "Vdac1; Vdac5", "gene_names_refseq": "Vdac1; Vdac5; mVDAC1; mVDAC5", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; VDAC-1; VDAC-5; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5; mVDAC1; mVDAC5", "protein_names_refseq": "non-selective voltage-gated ion channel VDAC1 isoform 2; non-selective voltage-gated ion channel VDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; voltage-dependent anion-selective channel protein 1; voltage-dependent anion-selective channel protein 5", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:22333); (R-MMU-5205685); (R-MMU-5689880); (R-MMU-70268)", "pathway_count": 4, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10716730;15477379;17208939;18034455;18539296;18988731;20887712;21183079;21540332;21750661;22645316;23576753;23806337;24908397;25168729;25428506;28935714;29907098;30084848;30779550;32047033;33293416;33300544;34203471;34428180;34799735;36288343;37453647;37507081;37828378;39927985;8660977", "class_list": "", "function": "Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:34799735). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:10716730, PubMed:15477379, PubMed:18988731). May mediate ATP export from cells (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (PubMed:29907098)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Multiple pseudogenes of this gene are found on chromosomes 1, 2, 3, 6, 8, 9, and X. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1ASZ9;Q5SVC6", "ec_number_list": "5.6.1.6;1.6.5.5;1.8.-.-;2.7.11.1;3.1.-.-;1.8.5.1", "go_molecular_function": "GO:0008142 oxysterol binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0006869 lipid transport;GO:0007612 learning;GO:0030855 epithelial cell differentiation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q60932-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUB4-1", "uniprot_id": "WDFY2_MOUSE", "mass": 45094.0, "length": 400, "protein_name": "WD repeat and FYVE domain-containing protein 2", "gene_name": "Wdfy2", "organism": "Mouse", "refseq_name": "WD repeat and FYVE domain-containing protein 2", "refseq_ac": "NP_780755", "gene_names_uniprotkb": "Wdfy2", "gene_names_refseq": "5830485M08; B130024L21Rik; ProF; Wdfy2; ZFYVE22", "protein_names_uniprotkb": "WD repeat and FYVE domain-containing protein 2; Prof; Propeller-FYVE protein; WD40- and FYVE domain-containing protein 2", "protein_names_refseq": "WD repeat and FYVE domain-containing protein 2; WD40- and FYVE domain-containing protein 2; propeller-FYVE protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:268752)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16792529;17313651;18388859;20189988;32641353", "class_list": "", "function": "Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (By similarity). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (PubMed:20189988). Participates in transferrin receptor endocytosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Data show that ProF binds to Foxo1, a negative regulator of insulin action and adipogenesis, and facilitates the phosphorylation and thus inactivation of Foxo1 by Akt., [RefSeq, PubMed]; The ProF protein partially co-localizes with EEA1 on vesicular structures and binds to the protein kinases Akt and PKCzeta/lambda (protein kinase Czeta/lambda) via its WD-repeat propeller., [RefSeq, PubMed]; WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9F3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0031982 vesicle", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BUB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R307-1", "uniprot_id": "VPS18_MOUSE", "mass": 110219.0, "length": 973, "protein_name": "Vacuolar protein sorting-associated protein 18 homolog", "gene_name": "Vps18", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 18 homolog", "refseq_ac": "NP_758473", "gene_names_uniprotkb": "Vps18", "gene_names_refseq": "9930024E13Rik; Vps18", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 18 homolog", "protein_names_refseq": "vacuolar protein sorting 18; vacuolar protein sorting-associated protein 18 homolog", "tax_id": 10090, "disease": "cholestasis (Disease Ontology:DOID:13580)", "pathway": " (mmu:228545)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14517315;14668490;21411634;22699122;22854957;25266290;28528544;31219806;34428180;34637763", "class_list": "", "function": "Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress., [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:14517315, PubMed:22854957). Involved in dendrite development of Pukinje cells (PubMed:22699122)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Vps18 deficiency severely blocks the dendrite development of Pukinje cells but not cerebral cortical neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGV6;Q8BZX6;Q8C126", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0019905 syntaxin binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005884 actin filament", "go_biological_process": "GO:0048284 organelle fusion;GO:0006886 intracellular protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920Q4-1", "uniprot_id": "VPS16_MOUSE", "mass": 94928.0, "length": 839, "protein_name": "Vacuolar protein sorting-associated protein 16 homolog", "gene_name": "Vps16", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vps16", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 16 homolog; mVPS16", "protein_names_refseq": "", "tax_id": 10090, "disease": "dystonia 30 (Disease Ontology:DOID:0060937); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": "", "pathway_count": 0, "publication_count": 17, "publication_id_list": "16800626;19224205;20173027;21411634;21750661;25266290;25428506;25428507;25605945;27174565;28011936;30084848;31219806;34428180;35820727;36210013;37828378", "class_list": "", "function": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BI91;Q8R3C3;Q99KZ4", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005884 actin filament;GO:0030424 axon", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0042144 vacuole fusion, non-autophagic;GO:0006886 intracellular protein transport;GO:0008333 endosome to lysosome transport;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q920Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BID6-1", "uniprot_id": "ZBT46_MOUSE", "mass": 65499.0, "length": 600, "protein_name": "Zinc finger and BTB domain-containing protein 46", "gene_name": "Zbtb46", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 46 isoform 1", "refseq_ac": "NP_081932", "gene_names_uniprotkb": "Zbtb46; Btbd4", "gene_names_refseq": "2610019F01Rik; 4933406L05Rik; BZEL; Btbd4; Zbtb46; zDC", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 46; BTB-ZF protein expressed in effector lymphocytes; BTB/POZ domain-containing protein 4; BZEL; zDC; zinc finger transcription factor zDC", "protein_names_refseq": "BTB (POZ) domain containing 4; BTB-ZF protein expressed in effector lymphocytes; BTB/POZ domain-containing protein 4; zinc finger and BTB domain-containing protein 46 isoform 1; zinc finger and BTB domain-containing protein 46; zinc finger transcription factor zDC", "tax_id": 10090, "disease": "", "pathway": " (mmu:72147)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22370726;22615127;22615130;22851594;30084848;35831503", "class_list": "", "function": "Expression of the Btbd4 defines the classical dendritic cell lineage, [RefSeq, PubMed]; Transcription regulator that mediates differentiation of conventional and non-conventional dendritic cells, and which is involved in tolerance to gut microbiota (PubMed:22615127, PubMed:22615130, PubMed:22851594, PubMed:35831503). Together with RORgammaT (RORC), specifically expressed in type 3 innate lymphoid cells (ILC3s) that are required for tolerance to gut microbiota, to mediate differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms (PubMed:35831503). Functions as a transcription corepressor for PRDM1 (PubMed:22370726)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Zbtb46 may help enforce dendritic cell identity by restricting responsiveness to non-dendritic cells growth factors and may serve as a useful marker to identify rare dendritic cell progenitors, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUD2;Q3U2R2;Q9D0G6;Q9D492", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:2001200 positive regulation of dendritic cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030853 negative regulation of granulocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BID6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08863-1", "uniprot_id": "BIRC3_MOUSE", "mass": 67228.0, "length": 600, "protein_name": "Baculoviral IAP repeat-containing protein 3", "gene_name": "Birc3", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 3", "refseq_ac": "NP_031490", "gene_names_uniprotkb": "Birc3", "gene_names_refseq": "Api1; Api2; Birc3; C-IAP2; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; MIHC; RNF49; cIAP-1; cIAP-2; cIAP1; cIAP2", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 3; 2.3.2.27; C-IAP2; Cellular inhibitor of apoptosis 2; Inhibitor of apoptosis protein 1; RING-type E3 ubiquitin transferase BIRC3; mIAP1", "protein_names_refseq": "RING-type E3 ubiquitin transferase BIRC3; apoptosis inhibitor 1; baculoviral IAP repeat-containing protein 3; cellular inhibitor of apoptosis 2; inhibitor of apoptosis protein 1", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:11796); (R-MMU-168638); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5668541); (R-MMU-5675482); (R-MMU-5676594); (R-MMU-5689880); (R-MMU-937041)", "pathway_count": 10, "publication_count": 7, "publication_id_list": "18621737;21750661;30084848;36440627;37209886;39128586;9441758", "class_list": "", "function": "Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury., [RefSeq, PubMed]; Endothelial Birc3 promotes renal fibrosis through modulating Drp1-mediated mitochondrial fission via MAPK/PI3K/Akt pathway., [RefSeq, PubMed]; M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination., [RefSeq, PubMed]; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLX3", "ec_number_list": "3.4.19.12;2.3.2.27;3.4.25.1;2.7.11.10;2.7.11.1;2.7.10.2;2.3.2.24;2.3.2.23;2.3.2.-;2.7.11.25;2.3.2.26;2.3.2.31", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0016740 transferase activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:2000378 negative regulation of reactive oxygen species metabolic process;GO:0031398 positive regulation of protein ubiquitination;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1Y4-1", "uniprot_id": "DEN4B_MOUSE", "mass": 164740.0, "length": 1499, "protein_name": "DENN domain-containing protein 4B", "gene_name": "Dennd4b", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 4B isoform 1", "refseq_ac": "NP_958809", "gene_names_uniprotkb": "Dennd4b; Bsg4; Bsp4; Kiaa0476", "gene_names_refseq": "Dennd4b", "protein_names_uniprotkb": "DENN domain-containing protein 4B; Brain specific protein 4; Brain-specific gene 4 protein", "protein_names_refseq": "DENN domain-containing protein 4B isoform 1; DENN domain-containing protein 4B; DENN/MADD domain containing 4B; brain specific protein 4; brain-specific gene 4 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:229541); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZJ7;Q6R5M4;Q80TZ2;Q80VU7;Q8CGE6;Q8R0E9", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U1Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYZ7-1", "uniprot_id": "ELMO3_MOUSE", "mass": 81758.0, "length": 720, "protein_name": "Engulfment and cell motility protein 3", "gene_name": "Elmo3", "organism": "Mouse", "refseq_name": "engulfment and cell motility protein 3", "refseq_ac": "NP_766348", "gene_names_uniprotkb": "Elmo3", "gene_names_refseq": "9930107J06; CED-12; Ced12; Elmo3", "protein_names_uniprotkb": "Engulfment and cell motility protein 3", "protein_names_refseq": "engulfment and cell motility 3, ced-12 homolog; engulfment and cell motility protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:234683)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;34428180", "class_list": "", "function": "Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDE4", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007015 actin filament organization;GO:0006909 phagocytosis;GO:0006915 apoptotic process;GO:0048870 cell motility;GO:2001212 regulation of vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BYZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUB4-1", "uniprot_id": "DCTN6_MOUSE", "mass": 20670.0, "length": 190, "protein_name": "Dynactin subunit 6", "gene_name": "Dctn6", "organism": "Mouse", "refseq_name": "dynactin subunit 6 isoform 1", "refseq_ac": "NP_001280686", "gene_names_uniprotkb": "Dctn6; Ws3", "gene_names_refseq": "Dctn6; WS-3; p27", "protein_names_uniprotkb": "Dynactin subunit 6; Dynactin subunit p27; Protein WS-3", "protein_names_refseq": "RGD containing protein; dynactin subunit 6 isoform 1; dynactin subunit 6; dynactin subunit p27; p27 dynactin subunit; protein WS-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22428); (R-MMU-2132295); (R-MMU-3371497); (R-MMU-6807878); (R-MMU-6811436)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10318868;10525537;21750661;23455152;25428506;34197691;34371284;36210013", "class_list": "", "function": "Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains., [RefSeq, PubMed]; Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit., [RefSeq, PubMed]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2M9;Q9QZB8", "ec_number_list": "", "go_molecular_function": "GO:0003824 catalytic activity;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005869 dynactin complex;GO:0000776 kinetochore", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0007005 mitochondrion organization;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WUB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67871-1", "uniprot_id": "CSK2B_MOUSE", "mass": 24942.0, "length": 215, "protein_name": "Casein kinase II subunit beta", "gene_name": "Csnk2b", "organism": "Mouse", "refseq_name": "casein kinase II subunit beta isoform 2", "refseq_ac": "NP_001290374", "gene_names_uniprotkb": "Csnk2b; Ck2n", "gene_names_refseq": "CK II beta; Csnk2b", "protein_names_uniprotkb": "Casein kinase II subunit beta; CK II beta; Phosvitin", "protein_names_refseq": "casein kinase II subunit beta isoform 2; phosvitin", "tax_id": 10090, "disease": "leiomyoma (Disease Ontology:DOID:127); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:13001); (R-MMU-1483191); (R-MMU-201688); (R-MMU-2514853); (R-MMU-445144); (R-MMU-6798695); (R-MMU-6804756); (R-MMU-6814122); (R-MMU-8934903); (R-MMU-8939243); (R-MMU-8948751); (R-MMU-9768727); (R-MMU-9929491)", "pathway_count": 13, "publication_count": 14, "publication_id_list": "10806215;12849985;14656967;16818610;2015307;21750661;2362816;31219806;31599954;33300544;34428180;35820727;37302538;8530080", "class_list": "", "function": "MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta., [RefSeq, PubMed]; Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07312;P13862;Q3TTJ7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0019046 release from viral latency;GO:0043537 negative regulation of blood vessel endothelial cell migration;GO:0016055 Wnt signaling pathway;GO:0033211 adiponectin-activated signaling pathway;GO:0032927 positive regulation of activin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P67871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMQ3-1", "uniprot_id": "BNC2_MOUSE", "mass": 125335.0, "length": 1127, "protein_name": "Zinc finger protein basonuclin-2", "gene_name": "Bnc2", "organism": "Mouse", "refseq_name": "zinc finger protein basonuclin-2 isoform 2", "refseq_ac": "NP_766458", "gene_names_uniprotkb": "Bnc2", "gene_names_refseq": "5031434M05Rik; 8430420F16Rik; Bnc2", "protein_names_uniprotkb": "Zinc finger protein basonuclin-2", "protein_names_refseq": "basonuclin 2; zinc finger protein basonuclin-2 isoform 2; zinc finger protein basonuclin-2", "tax_id": 10090, "disease": "urinary tract obstruction (Disease Ontology:DOID:5200)", "pathway": " (mmu:242509)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14988505;15081112;21750661;25428506;31051115;36852467;36960892", "class_list": "", "function": "Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis., [RefSeq, PubMed]; Gene expression profiling; structural and functional similarities with Basonuclin 1 suggest that Basonuclin2 may play an analogous function in germ cells and skin keratinocytes, [RefSeq, PubMed]; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development., [UniProtKB, UniProtKB]; The extreme conservation of the basonuclin 2 amino acid sequence across vertebrates suggests that basonuclin 2 serves an important function, presumably as a regulatory protein of DNA transcription, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "H3BIU0;Q6T3A4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000182 rDNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001650 fibrillar center;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0060021 roof of mouth development;GO:0003416 endochondral bone growth;GO:0043586 tongue development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BMQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UMY5-1", "uniprot_id": "EMAL4_MOUSE", "mass": 110027.0, "length": 988, "protein_name": "Echinoderm microtubule-associated protein-like 4", "gene_name": "Eml4", "organism": "Mouse", "refseq_name": "echinoderm microtubule-associated protein-like 4 isoform 2", "refseq_ac": "NP_001107834", "gene_names_uniprotkb": "Eml4", "gene_names_refseq": "4930443C24Rik; Eml4", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 4; EMAP-4", "protein_names_refseq": "EMAP-4; echinoderm microtubule-associated protein-like 4 isoform 2", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:78798); (R-MMU-9648025)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17196341;17242355;21183079;21750661;22872234;25428506;31219806;34203471;34428180;36210013", "class_list": "", "function": "Essential for the stability of microtubules (MTs) (PubMed:17196341). Essential for the formation of MTs (By similarity). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (By similarity). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS73;Q6NXL8;Q6NZJ8;Q6P1A7", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3UMY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX80-1", "uniprot_id": "ENASE_MOUSE", "mass": 82945.0, "length": 734, "protein_name": "Cytosolic endo-beta-N-acetylglucosaminidase", "gene_name": "Engase", "organism": "Mouse", "refseq_name": "cytosolic endo-beta-N-acetylglucosaminidase isoform 1", "refseq_ac": "NP_766161", "gene_names_uniprotkb": "Engase", "gene_names_refseq": "C130099A03; D230014K01Rik; Engase", "protein_names_uniprotkb": "Cytosolic endo-beta-N-acetylglucosaminidase; 3.2.1.96; ENGase", "protein_names_refseq": "cytosolic endo-beta-N-acetylglucosaminidase isoform 1; cytosolic endo-beta-N-acetylglucosaminidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:217364); (R-MMU-532668)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;23671108;26858256;28426790;32782141", "class_list": "glycogene;glycosylhydrolase", "function": "Cytosolic N-GlcNAc proteins are formed by the action of endo-beta-N-acetylglucosaminidase., [RefSeq, PubMed]; ENGase efficiently hydrolyzes phosphorylated oligosaccharides that are larger than Man4GlcNAc2-P, generating GlcNAc-1-P and neutral Gn1-type free oligosaccharides., [RefSeq, PubMed]; Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol (By similarity)., [UniProtKB]; These observations strongly suggest that the Ngly1- or Ngly1/Engase-deficient mice could serve as a valuable animal model for studies related to the pathogenesis of the NGLY1-deficiency, and that cytoplasmic ENGase represents one of the potential therapeutic targets for this genetic disorder. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 38, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK58;Q8BJF1", "ec_number_list": "3.2.1.96", "go_molecular_function": "GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006517 protein deglycosylation;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BX80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6Y685-1", "uniprot_id": "TACC1_MOUSE", "mass": 83952.0, "length": 774, "protein_name": "Transforming acidic coiled-coil-containing protein 1", "gene_name": "Tacc1", "organism": "Mouse", "refseq_name": "transforming acidic coiled-coil-containing protein 1 long isoform", "refseq_ac": "NP_796063", "gene_names_uniprotkb": "Tacc1", "gene_names_refseq": "4833447E04Rik; B230378H13Rik; Tacc1", "protein_names_uniprotkb": "Transforming acidic coiled-coil-containing protein 1", "protein_names_refseq": "transforming acidic coiled-coil-containing protein 1 long isoform", "tax_id": 10090, "disease": "", "pathway": " (mmu:320165)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15207008;19144319;20078863;21183079;21750661;22645316;26495903;27338930;28528544;34428180", "class_list": "", "function": "Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors (By similarity). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues., [UniProtKB, UniProtKB]; We show that T cells deficient for acetyl-CoA carboxylase 1 (TACC1) are dramatically less pathogenic than wild-type (WT) T cells in a lethal C57BL/6 into BALB/c model of acute GVHD and permitted sustained survival of recipient mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05A66;Q6Y686", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0030331 nuclear estrogen receptor binding;GO:0042974 nuclear retinoic acid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030496 midbody", "go_biological_process": "GO:0008283 cell population proliferation;GO:0051301 cell division;GO:0021987 cerebral cortex development;GO:0032886 regulation of microtubule-based process;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6Y685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBV3-1", "uniprot_id": "DHX34_MOUSE", "mass": 128507.0, "length": 1145, "protein_name": "Probable ATP-dependent RNA helicase DHX34", "gene_name": "Dhx34", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DHX34", "refseq_ac": "NP_001272860", "gene_names_uniprotkb": "Dhx34; Ddx34; Kiaa0134", "gene_names_refseq": "1200013B07Rik; 1810012L18Rik; Ddx34; Dhx34; mKIAA0134", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DHX34; 3.6.4.13; DEAH box protein 34; DExH-box helicase 34", "protein_names_refseq": "DEAH (Asp-Glu-Ala-His) box polypeptide 34; DEAH box protein 34; probable ATP-dependent RNA helicase DHX34", "tax_id": 10090, "disease": "", "pathway": " (mmu:71723)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probable ATP-binding RNA helicase (By similarity). Required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons (By similarity). Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3 (By similarity). Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0004386 helicase activity", "go_cellular_component": "", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042327 positive regulation of phosphorylation;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DBV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64444-1", "uniprot_id": "CAH4_MOUSE", "mass": 34351.0, "length": 305, "protein_name": "Carbonic anhydrase 4", "gene_name": "Ca4; Car4", "organism": "Mouse", "refseq_name": "carbonic anhydrase 4 isoform 1 precursor", "refseq_ac": "NP_031633", "gene_names_uniprotkb": "Ca4; Car4; Car4", "gene_names_refseq": "Ca4; Car4", "protein_names_uniprotkb": "Carbonic anhydrase 4; 4.2.1.1; CA-IV; Carbonate dehydratase IV; Carbonic anhydrase IV", "protein_names_refseq": "CA-IV; carbonate dehydratase IV; carbonic anhydrase 4 isoform 1 precursor; carbonic anhydrase IV", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:12351); (R-MMU-1237044); (R-MMU-1247673); (R-MMU-1475029)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14567693;21750661;30899004;8935991;9541386", "class_list": "glycogene", "function": "Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0015701 bicarbonate transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQC6-1", "uniprot_id": "5MP2_MOUSE", "mass": 48043.0, "length": 419, "protein_name": "eIF5-mimic protein 2", "gene_name": "Bzw1", "organism": "Mouse", "refseq_name": "eIF5-mimic protein 2", "refseq_ac": "NP_080100", "gene_names_uniprotkb": "Bzw1; 5mp2", "gene_names_refseq": "1200015E15Rik; Bzw1; mKIAA0005", "protein_names_uniprotkb": "eIF5-mimic protein 2; Basic leucine zipper and W2 domain-containing protein 1", "protein_names_refseq": "basic leucine zipper and W2 domain-containing protein 1; eIF5-mimic protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66882)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16452087;16690031;21183079;21750661;34428180;36333315;37828427", "class_list": "", "function": "Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. Publication Status: Online-Only, [RefSeq, PubMed]; Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity)., [UniProtKB, UniProtKB]; Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THS5;Q3UZ94", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6J756-1", "uniprot_id": "CAN11_MOUSE", "mass": 82970.0, "length": 714, "protein_name": "Calpain-11", "gene_name": "Capn11", "organism": "Mouse", "refseq_name": "calpain-11", "refseq_ac": "NP_001013789", "gene_names_uniprotkb": "Capn11", "gene_names_refseq": "Capn11", "protein_names_uniprotkb": "Calpain-11; 3.4.22.-; CANP 11; Calcium-activated neutral proteinase 11", "protein_names_refseq": "CANP 11; calcium-activated neutral proteinase 11; calcium-dependent thiol protease; calpain-11", "tax_id": 10090, "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:268958); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10559499;16495451;16541461;21750661", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction., [UniProtKB, UniProtKB]; Collectively, these results reveal a novel role of CRMP-3 in that calpain cleavage of CRMP-3 and the subsequent nuclear translocation of the truncated CRMP-3 evokes neuronal death in response to excitotoxicity and cerebral ischemia., [RefSeq, PubMed]; Results demonstrate that calpain 11 is expressed specifically in the mouse testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6J756-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WR5-1", "uniprot_id": "CA174_MOUSE", "mass": 24774.0, "length": 230, "protein_name": "UPF0688 protein C1orf174 homolog", "gene_name": "A430005L14Rik", "organism": "Mouse", "refseq_name": "UPF0688 protein C1orf174 homolog isoform 2", "refseq_ac": "NP_001156491", "gene_names_uniprotkb": "A430005L14Rik", "gene_names_refseq": "A430005L14Rik", "protein_names_uniprotkb": "UPF0688 protein C1orf174 homolog", "protein_names_refseq": "UPF0688 protein C1orf174 homolog isoform 2; UPF0688 protein C1orf174 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:97159)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AM12;Q8CA21", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80WR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00920-1", "uniprot_id": "CAH2_MOUSE", "mass": 29033.0, "length": 260, "protein_name": "Carbonic anhydrase 2", "gene_name": "Ca2; Car2", "organism": "Mouse", "refseq_name": "carbonic anhydrase 2", "refseq_ac": "NP_033931", "gene_names_uniprotkb": "Ca2; Car2; Car2", "gene_names_refseq": "CAII; Ca2; Car-2; Car2; Ltw-5; Lvtw-5", "protein_names_uniprotkb": "Carbonic anhydrase 2; 4.2.1.1; 4.2.1.69; CA-II; Carbonate dehydratase II; Carbonic anhydrase II; Cyanamide hydratase CA2", "protein_names_refseq": "carbonate dehydratase II; carbonic anhydrase 2; carbonic anhydrase II; cyanamide hydratase CA2", "tax_id": 10090, "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal recessive osteopetrosis 3 (Disease Ontology:DOID:0110941); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); osteopetrosis (Disease Ontology:DOID:13533); viral hepatitis (Disease Ontology:DOID:1884); Lynch syndrome (Disease Ontology:DOID:3883); bladder urothelial carcinoma (Disease Ontology:DOID:4006); alcoholic pancreatitis (Disease Ontology:DOID:4988); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:12349); (R-MMU-1237044); (R-MMU-1247673); (R-MMU-1475029)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "20150244;21183079;21750661;26495903;2995362;3000449;36288343;36709914;37507081;38731991;39927985;6187736;6331255;6420240", "class_list": "", "function": "Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney Cysts Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in TSC. Publication Status: Online-Only, [RefSeq, PubMed]; Carbonic anhydrase II deficiency., [RefSeq, PubMed]; Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (By similarity). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LDQ7;Q7TPE1;Q9DCT3;Q9DCY9", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004064 arylesterase activity;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0010043 response to zinc ion;GO:0001822 kidney development;GO:0045780 positive regulation of bone resorption;GO:0048545 response to steroid hormone;GO:0038166 angiotensin-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00920-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXV2-1", "uniprot_id": "BRI3B_MOUSE", "mass": 28263.0, "length": 253, "protein_name": "BRI3-binding protein", "gene_name": "Bri3bp", "organism": "Mouse", "refseq_name": "BRI3-binding protein isoform 1", "refseq_ac": "NP_084028", "gene_names_uniprotkb": "Bri3bp", "gene_names_refseq": "2410150I18Rik; Bri3bp", "protein_names_uniprotkb": "BRI3-binding protein; I3-binding protein", "protein_names_refseq": "BRI3-binding protein isoform 1; BRI3-binding protein; I3-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76809)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17943721;21540332;21750661;31219806;34428180", "class_list": "", "function": "Involved in tumorigenesis and may function by stabilizing p53/TP53., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXP1;Q9CWE5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BXV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UAW9-1", "uniprot_id": "BRF2_MOUSE", "mass": 47050.0, "length": 420, "protein_name": "Transcription factor IIIB 50 kDa subunit", "gene_name": "Brf2", "organism": "Mouse", "refseq_name": "transcription factor IIIB 50 kDa subunit", "refseq_ac": "NP_079962", "gene_names_uniprotkb": "Brf2", "gene_names_refseq": "2700059M06Rik; 5730512K07Rik; BRFU; Brf2; TFIIIB50", "protein_names_uniprotkb": "Transcription factor IIIB 50 kDa subunit; B-related factor 2; BRF-2", "protein_names_refseq": "B-related factor 2; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; transcription factor IIIB 50 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:66653); (R-MMU-76071)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZF0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000126 transcription factor TFIIIB complex", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0006359 regulation of transcription by RNA polymerase III;GO:0070897 transcription preinitiation complex assembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UAW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K479-1", "uniprot_id": "C1QT5_MOUSE", "mass": 25437.0, "length": 243, "protein_name": "Complement C1q tumor necrosis factor-related protein 5", "gene_name": "C1qtnf5", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 5 precursor", "refseq_ac": "NP_001035721", "gene_names_uniprotkb": "C1qtnf5; Ctrp5", "gene_names_refseq": "Adie; C1qtnf5; Ctrp5; Mfrp", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 5", "protein_names_refseq": "Membrane frizzled-related protein; adiponectin e; complement C1q tumor necrosis factor-related protein 5 precursor; complement C1q tumor necrosis factor-related protein 5", "tax_id": 10090, "disease": "isolated microphthalmia 5 (Disease Ontology:DOID:0060837); late-onset retinal degeneration (Disease Ontology:DOID:0060869); nanophthalmos (Disease Ontology:DOID:0080634); retinitis pigmentosa (Disease Ontology:DOID:10584); microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (mmu:235312)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12140190;16600989;17122142;21750661;22351773;38246238", "class_list": "", "function": "C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus., [RefSeq, PubMed]; CTRP5, a secretory and membrane-associated protein, is localized to the lateral and apical membranes of the RPE and CB. Impaired secretion of the mutant protein may underlie the pathophysiology of long anterior zonules and late-onset retinal degeneration., [RefSeq, PubMed]; L-ORMD is due to insufficient levels of secreted C1QTNF5, compromised RPE cell function resulting from ER retention of the mutant protein or both mechanisms., [RefSeq, PubMed]; The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0009306 protein secretion;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K479-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3I9-1", "uniprot_id": "B3GN8_MOUSE", "mass": 43370.0, "length": 389, "protein_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8", "gene_name": "B3gnt8", "organism": "Mouse", "refseq_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8", "refseq_ac": "NP_001031817", "gene_names_uniprotkb": "B3gnt8; B3galt7", "gene_names_refseq": "B3galt7; B3gnt8; B7galt7", "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8; 2.4.1.-; 2.4.1.149; BGnT-8; Beta-1,3-Gn-T8; Beta-1,3-N-acetylglucosaminyltransferase 8; Beta3Gn-T8; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8", "protein_names_refseq": "BGnT-8; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8; UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7; beta-1,3-Gn-T8; beta-1,3-N-acetylglucosaminyltransferase 8; beta3Gn-T8", "tax_id": 10090, "disease": "", "pathway": " (mmu:232984); (R-MMU-913709)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18826941;21750661", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-N-acetylglucosaminyltransferase that functions in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans., [UniProtKB, PubMed]; Up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.149;2.4.1.147;2.4.1.146;2.4.1.206", "go_molecular_function": "GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016262 protein N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 1159, "hit_score": 0.3, "record_id": "Q8R3I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZW9-1", "uniprot_id": "C209C_MOUSE", "mass": 21245.0, "length": 178, "protein_name": "CD209 antigen-like protein C", "gene_name": "Cd209c", "organism": "Mouse", "refseq_name": "CD209 antigen-like protein C", "refseq_ac": "NP_570973", "gene_names_uniprotkb": "Cd209c", "gene_names_refseq": "Cd209c; SIGNR2; mSIGNR2", "protein_names_uniprotkb": "CD209 antigen-like protein C; DC-SIGN-related protein 2; DC-SIGNR2", "protein_names_refseq": "CD209 antigen-like protein C; DC-SIGN-related protein 2; DC-SIGNR2", "tax_id": 10090, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); rheumatic heart disease (Disease Ontology:DOID:0050827); Coronavirus infectious disease (Disease Ontology:DOID:0080599); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); aspergillosis (Disease Ontology:DOID:13564); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:170776)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11581173;21750661", "class_list": "glycogene", "function": "Probable pathogen-recognition receptor. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB37", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0001618 virus receptor activity;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity;GO:0004895 cell adhesion receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007159 leukocyte cell-cell adhesion;GO:0046718 symbiont entry into host cell;GO:0042102 positive regulation of T cell proliferation;GO:1903902 positive regulation of viral life cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91ZW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55284-1", "uniprot_id": "CADH5_MOUSE", "mass": 87903.0, "length": 784, "protein_name": "Cadherin-5", "gene_name": "Cdh5", "organism": "Mouse", "refseq_name": "cadherin-5 preproprotein", "refseq_ac": "NP_033998", "gene_names_uniprotkb": "Cdh5", "gene_names_refseq": "7B4; Cd144; Cdh5; VE-Cad; VECD; VEcad; Vec", "protein_names_uniprotkb": "Cadherin-5; VE-cadherin; Vascular endothelial cadherin", "protein_names_refseq": "7B4/cadherin-5; VE-cadherin; cadherin-5 preproprotein; vascular endothelial cadherin", "tax_id": 10090, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); coronary artery disease (Disease Ontology:DOID:3393); thyroid gland carcinoma (Disease Ontology:DOID:3963); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:12562); (R-MMU-418990); (R-MMU-5218920)", "pathway_count": 3, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;12234928;15861137;19635461;20047332;20332120;20530207;21695048;21750661;22492353;23306156;23575676;23575677;24487320;24806444;24858855;25377089;25924235;26668327;27005951;27466317;28119542;28179430;28694388;29381707;29796309;29797291;31504252;32733273;33908348;33972531;34428180;8555485;9220534", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (PubMed:20332120, PubMed:9220534). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (PubMed:24806444). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (PubMed:27466317). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Positively regulates reorientation of actin stress fibers and endothelial cell reorientation in response to cellular mechantransduction (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). Associates with CTNND1/p120-catenin to control CADH5 endocytosis (PubMed:33972531)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35542", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P55284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6L8S8-1", "uniprot_id": "B4GN3_MOUSE", "mass": 113509.0, "length": 986, "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase 3", "gene_name": "B4galnt3", "organism": "Mouse", "refseq_name": "beta-1,4-N-acetylgalactosaminyltransferase 3", "refseq_ac": "NP_942585", "gene_names_uniprotkb": "B4galnt3", "gene_names_refseq": "B4GalNAcT3; B4galnt3; C330047A21", "protein_names_uniprotkb": "Beta-1,4-N-acetylgalactosaminyltransferase 3; 2.4.1.244; Beta-1,4-N-acetylgalactosaminyltransferase III; Beta4GalNAc-T3; Beta4GalNAcT3; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2; NGalNAc-T2", "protein_names_refseq": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2; NGalNAc-T2; beta 1,4-N-acetylgalactosaminyltransferase-transferase 3; beta 1,4-N-acetylgalactosaminyltransferase-transferase-III; beta-1,4-N-acetylgalactosaminyltransferase 3; beta-1,4-N-acetylgalactosaminyltransferase III; beta4GalNAc-T3; beta4GalNAcT3", "tax_id": 10090, "disease": "", "pathway": " (mmu:330406)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12966086;17579116;21750661;22722937;22722940;25428506", "class_list": "glycogene;glycosyltransferase", "function": "Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Up-regulation of beta4GalNAc-T3 may play a critical role in promoting tumor malignanc, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 49, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.244", "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0033842 N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 865, "hit_score": 0.7, "record_id": "Q6L8S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62325-1", "uniprot_id": "BTG1_MOUSE", "mass": 19209.0, "length": 171, "protein_name": "Protein BTG1", "gene_name": "Btg1", "organism": "Mouse", "refseq_name": "protein BTG1", "refseq_ac": "NP_031595", "gene_names_uniprotkb": "Btg1", "gene_names_refseq": "Btg1", "protein_names_uniprotkb": "Protein BTG1; B-cell translocation gene 1 protein", "protein_names_refseq": "B cell translocation gene 1, anti-proliferative; B-cell translocation gene 1 protein; protein BTG1", "tax_id": 10090, "disease": "protein-energy malnutrition (Disease Ontology:DOID:11801); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:12226)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;36656933;37062247;8325512", "class_list": "", "function": "Anti-proliferative protein., [UniProtKB, UniProtKB, UniProtKB]; BTG1 mutation yields supercompetitive B cells primed for malignant transformation., [RefSeq, PubMed]; Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P31607", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0043085 positive regulation of catalytic activity;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62325-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922D8-1", "uniprot_id": "C1TC_MOUSE", "mass": 101200.0, "length": 935, "protein_name": "C-1-tetrahydrofolate synthase, cytoplasmic", "gene_name": "Mthfd1", "organism": "Mouse", "refseq_name": "C-1-tetrahydrofolate synthase, cytoplasmic", "refseq_ac": "NP_620084", "gene_names_uniprotkb": "Mthfd1", "gene_names_refseq": "Dcs; E430024A07Rik; Mthfd1; Mthfd", "protein_names_uniprotkb": "C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase", "protein_names_refseq": "C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; C1-tetrahydrofolate synthase", "tax_id": 10090, "disease": "spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); developmental cardiac valvular defect (Disease Ontology:DOID:0080633); Down syndrome (Disease Ontology:DOID:14250); tetralogy of Fallot (Disease Ontology:DOID:6419); cleft palate (Disease Ontology:DOID:674); abdominal aortic aneurysm (Disease Ontology:DOID:7693); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:108156); (R-MMU-196757)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "12061812;15611115;18250455;19033438;21750661;22872234;26495903;28935714;29187734;31219806;34428180;35820727;35984892;37453647;37828378;38336749;39627609;39927985", "class_list": "", "function": "MTHFD1 has a role in production of monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria, [RefSeq, PubMed]; MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Mammalian mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase derived from a trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase., [RefSeq, PubMed]; Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism., [RefSeq, PubMed]; This gene encodes a trifunctional cytoplasmic enzyme. The encoded protein functions as a methylenetetrahydrofolate dehydrogenase, a methenyltetrahydrofolate cyclohydrolase, and a formyltetrahydrofolate synthase. The encoded enzyme functions in de novo synthesis of purines and thymidylate and in regeneration of methionine from homocysteine. [provided by RefSeq, Oct 2009]., [RefSeq]; Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R013", "ec_number_list": "1.5.1.5;3.5.4.9;1.5.1.15;6.3.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009152 purine ribonucleotide biosynthetic process;GO:0007507 heart development;GO:0001843 neural tube closure;GO:0046655 folic acid metabolic process;GO:0001780 neutrophil homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q922D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QWK5-1", "uniprot_id": "BIR1A_MOUSE", "mass": 158724.0, "length": 1403, "protein_name": "Baculoviral IAP repeat-containing protein 1a", "gene_name": "Naip1", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 1a", "refseq_ac": "NP_032696", "gene_names_uniprotkb": "Naip1; Birc1a; Naip", "gene_names_refseq": "Birc1a; D13Lsd1; Naip-rs1; Naip1; Naip", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 1a; Neuronal apoptosis inhibitory protein 1", "protein_names_refseq": "baculoviral IAP repeat-containing 1a; baculoviral IAP repeat-containing protein 1a; neuronal apoptosis inhibitory protein 1", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866)", "pathway": " (mmu:17940)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10501978;10958627;20173027;21750661;27114610;31219806;36427489;37586642;9693038", "class_list": "", "function": "Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals (By similarity)., [UniProtKB]; Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection., [RefSeq, PubMed]; Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis., [RefSeq, PubMed]; These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RT89;Q9JIB5;Q9R017", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process;GO:0016045 detection of bacterium;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QWK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A6M5-1", "uniprot_id": "CACO2_MOUSE", "mass": 40136.0, "length": 331, "protein_name": "Calcium-binding and coiled-coil domain-containing protein 2", "gene_name": "Calcoco2", "organism": "Mouse", "refseq_name": "calcium-binding and coiled-coil domain-containing protein 2", "refseq_ac": "NP_001257947", "gene_names_uniprotkb": "Calcoco2; Ndp52l1; Ndp52", "gene_names_refseq": "2410154J16Rik; Calcoco2; Ndp52l1; Ndp52", "protein_names_uniprotkb": "Calcium-binding and coiled-coil domain-containing protein 2; Nuclear domain 10 protein 52; Nuclear domain 10 protein NDP52", "protein_names_refseq": "calcium-binding and coiled-coil domain-containing protein 2; nuclear domain 10 protein 52 like 1; nuclear domain 10 protein NDP52", "tax_id": 10090, "disease": "", "pathway": " (mmu:76815)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12620990;20485683;21552525;21632568;25450380;34382418;39269442", "class_list": "", "function": "Expression and association of NDP52 with autophagy-regulated gene proteins including LC3, as well as phosphorylated tau and amyloid-beta in brains of an Alzheimer disease model, [RefSeq, PubMed]; ND10 and ND10 components might be important defensive factors against the CMV cross-species infection Publication Status: Online-Only, [RefSeq, PubMed]; NDP52 Protects Against Myocardial Infarction-Provoked Cardiac Anomalies Through Promoting Autophagosome-Lysosome Fusion via Recruiting TBK1 and RAB7., [RefSeq, PubMed]; The authors conclude that the dispersion of ND10 by major immediate-early protein 1 (IE1) appears not to be important for murine cytomegalovirus replication in a mouse-cell culture., [RefSeq, PubMed]; Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK36;Q3TKZ6;Q3TL30;Q9CWE3", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1901098 positive regulation of autophagosome maturation;GO:0098792 xenophagy;GO:0034341 response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2A6M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08901-1", "uniprot_id": "BUB1_MOUSE", "mass": 119563.0, "length": 1058, "protein_name": "Mitotic checkpoint serine/threonine-protein kinase BUB1", "gene_name": "Bub1", "organism": "Mouse", "refseq_name": "mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1", "refseq_ac": "NP_001106650", "gene_names_uniprotkb": "Bub1", "gene_names_refseq": "Bub1a; Bub1; D2Xrf87", "protein_names_uniprotkb": "Mitotic checkpoint serine/threonine-protein kinase BUB1; 2.7.11.1; BUB1A; mBUB1", "protein_names_refseq": "budding uninhibited by benzimidazoles 1 homolog; mBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1; mitotic checkpoint serine/threonine-protein kinase BUB1", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 30 (Disease Ontology:DOID:0051041); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12235); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 14, "publication_id_list": "17925231;17938250;19772675;21750661;25428506;25605945;30084848;30779550;31219806;32782141;34428180;38477771;9182760;9441741", "class_list": "", "function": "Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFalpha-mediated osteoclastogenesis., [RefSeq, PubMed]; Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (By similarity). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. Essential during early and later stages of embryonic development. Necessary for postimplantation embryogenesis and proliferation of primary embryonic fibroblasts and plays an important role in spermatogenesis and fertility., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O09007", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;3.6.5.-;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.4.22.49;3.6.5.2;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.4.21.-;2.3.1.48;4.1.1.32;3.6.4.12;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.3.2.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0140995 histone H2A kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0006915 apoptotic process;GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08901-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BGH0-1", "uniprot_id": "BPIB4_MOUSE", "mass": 65723.0, "length": 617, "protein_name": "BPI fold-containing family B member 4", "gene_name": "Bpifb4", "organism": "Mouse", "refseq_name": "BPI fold-containing family B member 4 isoform 1 precursor", "refseq_ac": "NP_001030047", "gene_names_uniprotkb": "Bpifb4; Gm1006; Lplunc4", "gene_names_refseq": "Bpifb4; Gm1006; Lplunc4", "protein_names_uniprotkb": "BPI fold-containing family B member 4; Long palate, lung and nasal epithelium carcinoma-associated protein 4", "protein_names_refseq": "BPI fold-containing family B member 4 isoform 1 precursor; LBP / BPI / CETP family, N-terminal domain containing protein; Novel LBP/BPI/CETP family, N-terminal domain containing protein; ligand-binding protein RY2G5; long palate, lung and nasal epithelium carcinoma-associated protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:381399); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14739326;21750661;25428506;28419216;32683420;36499641;36635236;37582912;38884925", "class_list": "", "function": "BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]; LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism., [RefSeq, PubMed]; Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in the STHdh Cell Model of Huntington Disease. Publication Status: Online-Only, [RefSeq, PubMed]; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity)., [UniProtKB, UniProtKB]; The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets., [RefSeq, PubMed]; The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy., [RefSeq, PubMed]; The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPM5", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0042254 ribosome biogenesis;GO:0009303 rRNA transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2BGH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88282-1", "uniprot_id": "BCL6B_MOUSE", "mass": 51339.0, "length": 474, "protein_name": "B-cell CLL/lymphoma 6 member B protein", "gene_name": "Bcl6b", "organism": "Mouse", "refseq_name": "B-cell CLL/lymphoma 6 member B protein", "refseq_ac": "NP_031554", "gene_names_uniprotkb": "Bcl6b; Bazf", "gene_names_refseq": "Bazf; Bcl6b", "protein_names_uniprotkb": "B-cell CLL/lymphoma 6 member B protein; Bcl6-associated zinc finger protein", "protein_names_refseq": "B-cell CLL/lymphoma 6 member B protein; BcL6-associated zinc finger protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12029)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11374866;12659862;15314041;21750661;31288844;37078291;9632807", "class_list": "", "function": "Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6., [UniProtKB, PubMed, PubMed]; BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing., [RefSeq, PubMed]; DNA-binding protein; gene expression regulation; binds STAT6 elements; binding site specificity, [RefSeq, PubMed]; Epigenetic inactivation of Bcl6b promotes gastric cancer through amplification of the gastric inflammatory response in vivo Publication Status: Online-Only, [RefSeq, PubMed]; Represses Bcl6-dependent transcription., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCJ6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation;GO:0002682 regulation of immune system process;GO:0050727 regulation of inflammatory response;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4QPC6-1", "uniprot_id": "BT2A2_MOUSE", "mass": 58455.0, "length": 514, "protein_name": "Butyrophilin subfamily 2 member A2", "gene_name": "Btn2a2", "organism": "Mouse", "refseq_name": "butyrophilin subfamily 2 member A2 isoform 1 precursor", "refseq_ac": "NP_001276544", "gene_names_uniprotkb": "Btn2a2", "gene_names_refseq": "Btn2a2; Btn2; D030063K05", "protein_names_uniprotkb": "Butyrophilin subfamily 2 member A2", "protein_names_refseq": "butyrophilin 2; butyrophilin subfamily 2 member A2 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:238555); (R-MMU-8851680)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20208008;21750661;26809444;34421818;35145516;37356345", "class_list": "", "function": "Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses. Publication Status: Online-Only, [RefSeq, PubMed]; Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis., [RefSeq, PubMed]; Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease., [RefSeq, PubMed]; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion., [UniProtKB, PubMed]; RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption. Publication Status: Online-Only, [RefSeq, PubMed]; These data are consistent with a coinhibitory role for mouse Butyrophilins, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q811T8", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0001817 regulation of cytokine production;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A4QPC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BU51-1", "uniprot_id": "BPIB6_MOUSE", "mass": 48781.0, "length": 449, "protein_name": "BPI fold-containing family B member 6", "gene_name": "Bpifb6", "organism": "Mouse", "refseq_name": "BPI fold-containing family B member 6 precursor", "refseq_ac": "NP_955007", "gene_names_uniprotkb": "Bpifb6; Bpil3; Gm119", "gene_names_refseq": "Bpifb6; Bpil3; Gm119; Lplunc6", "protein_names_uniprotkb": "BPI fold-containing family B member 6; Bactericidal/permeability-increasing protein-like 3", "protein_names_refseq": "BPI fold-containing family B member 6 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:228796); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2APD0;Q80ZU8", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BU51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUK4-1", "uniprot_id": "BIR1B_MOUSE", "mass": 164083.0, "length": 1447, "protein_name": "Baculoviral IAP repeat-containing protein 1b", "gene_name": "Naip2", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 1b", "refseq_ac": "NP_001119654", "gene_names_uniprotkb": "Naip2; Birc1b; Naip-rs6", "gene_names_refseq": "Birc1b; Naip-rs6; Naip2", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 1b; Neuronal apoptosis inhibitory protein 2", "protein_names_refseq": "baculoviral IAP repeat-containing protein 1b; neuronal apoptosis inhibitory protein, related sequence 6", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:17948)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10384056;10486205;10501978;18250455;20173027;21750661;21874021;21918512;24516390;27045008;27114610;31219806;34418053;34428180;36210013;8975718", "class_list": "", "function": "Activation of caspase-1 by Shigella is triggered by the rod protein MxiI that interacts with Naip2 to induce activation of the Nlrc4 inflammasome independently of the Pkcdelta kinase Publication Status: Online-Only, [RefSeq, PubMed]; Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin., [RefSeq, PubMed]; Sensor component of the NLRC4 inflammasome that specifically recognizes and binds type III secretion system (T3SS) rod proteins such as S.typhimurium (Salmonella) PrgJ and B.thailandensis BsaK from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals., [UniProtKB, PubMed, PubMed]; These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9C470;O09124;Q9R030", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QUK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499E0-1", "uniprot_id": "BRNP3_MOUSE", "mass": 88483.0, "length": 766, "protein_name": "BMP/retinoic acid-inducible neural-specific protein 3", "gene_name": "Brinp3", "organism": "Mouse", "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 3 isoform 1 precursor", "refseq_ac": "NP_001139279", "gene_names_uniprotkb": "Brinp3; Fam5c", "gene_names_refseq": "B830045N13Rik; Brinp3; Fam5c", "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 3", "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 3 isoform 1 precursor; BMP/retinoic acid-inducible neural-specific protein 3; family with sequence similarity 5, member C; protein FAM5C", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); aggressive periodontitis (Disease Ontology:DOID:1474); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:215378)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17138656;20025061;21750661;22245424;25428506", "class_list": "", "function": "FAM5C might be an important humoral bone anabolic factor produced from muscle cells., [RefSeq, PubMed]; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0R9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0035640 exploration behavior;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q499E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18761-1", "uniprot_id": "CAH6_MOUSE", "mass": 36495.0, "length": 317, "protein_name": "Carbonic anhydrase 6", "gene_name": "Ca6; Car6", "organism": "Mouse", "refseq_name": "carbonic anhydrase 6 precursor", "refseq_ac": "NP_033932", "gene_names_uniprotkb": "Ca6; Car6; Car6", "gene_names_refseq": "Ca6; Car6; DOC1", "protein_names_uniprotkb": "Carbonic anhydrase 6; 4.2.1.1; CA-VI; Carbonate dehydratase VI; Carbonic anhydrase VI; Salivary carbonic anhydrase; Secreted carbonic anhydrase", "protein_names_refseq": "CA-VI; carbonate dehydratase VI; carbonic anhydrase 6 precursor; carbonic anhydrase VI; salivary carbonic anhydrase; secreted carbonic anhydrase", "tax_id": 10090, "disease": "", "pathway": " (mmu:12353); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;2497732;27209317;28739930;9858573", "class_list": "", "function": "He altered biological processes included antigen transport by M-cells, potassium transport, muscle contraction, and thyroid hormone synthesis. Immunohistochemical staining confirmed the absence of CA VI in the submandibular gland of Car6 (-/-) mice, [RefSeq, PubMed]; Reversible hydration of carbon dioxide. Its role in saliva is unknown., [UniProtKB, UniProtKB, UniProtKB]; The nuclear localized CA-VI B selectively promotes IL-12 expression by interaction with protein arginine N-methyltransferase 5 (PRMT5), which reduces symmetric dimethylation of histone H3 arginine 8 modification (H3R8me2s) at Il12 promoters to facilitate chromatin accessibility, selectively enhancing c-Rel binding to the Il12b promoter., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ARR5;O88625", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHL7-1", "uniprot_id": "C42S1_MOUSE", "mass": 9076.0, "length": 80, "protein_name": "CDC42 small effector protein 1", "gene_name": "Cdc42se1", "organism": "Mouse", "refseq_name": "CDC42 small effector protein 1", "refseq_ac": "NP_001033797", "gene_names_uniprotkb": "Cdc42se1", "gene_names_refseq": "1300002M12Rik; Cdc42se1; Cdcse1; SCIP1; Spec1", "protein_names_uniprotkb": "CDC42 small effector protein 1", "protein_names_refseq": "CDC42 small effector protein 1; small protein effector 1 of Cdc42", "tax_id": 10090, "disease": "", "pathway": " (mmu:57912)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030054 cell junction;GO:0005737 cytoplasm", "go_biological_process": "GO:0006909 phagocytosis;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0046329 negative regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQ38-1", "uniprot_id": "CAND1_MOUSE", "mass": 136332.0, "length": 1230, "protein_name": "Cullin-associated NEDD8-dissociated protein 1", "gene_name": "Cand1", "organism": "Mouse", "refseq_name": "cullin-associated NEDD8-dissociated protein 1", "refseq_ac": "NP_082270", "gene_names_uniprotkb": "Cand1; D10Ertd516e; Kiaa0829", "gene_names_refseq": "2310038O07Rik; 6330512O03Rik; Cand1; D10Ertd516e; Tp120a; mKIAA0829", "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; p120 CAND1", "protein_names_refseq": "TBP-interacting protein; cullin-associated NEDD8-dissociated protein 1; cullin-associated and neddylation-dissociated protein 1; p120 CAND1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:71902); (R-MMU-6798695); (R-MMU-8951664); (R-MMU-917937)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25428506;25605945;28011936;29499133;30084848;31219806;31599954;33300544;34428180;35661710;36210013;37507081;39627609;39927985", "class_list": "", "function": "Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation., [RefSeq, PubMed]; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity)., [UniProtKB]; The adaptive exchange hypothesis, which posits that regulation of the koff of an FBP from SCF by the actions of substrate, Nedd8, and Cand1 molds the cellular repertoire of SCF complexes and that the plasticity afforded by this exchange mechanism may enable large variations in FBP expression during development and in FBP gene number during evolution., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFR0;Q9CV45", "ec_number_list": "", "go_molecular_function": "GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0043086 negative regulation of catalytic activity;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0010265 SCF complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6ZQ38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUN3-1", "uniprot_id": "BLNK_MOUSE", "mass": 50671.0, "length": 457, "protein_name": "B-cell linker protein", "gene_name": "Blnk", "organism": "Mouse", "refseq_name": "B-cell linker protein isoform 1", "refseq_ac": "NP_032554", "gene_names_uniprotkb": "Blnk; Bash; Ly57; Slp65", "gene_names_refseq": "BASH; Bca; Blnk; Ly-57; Ly57; Lyw-57; SLP-65", "protein_names_uniprotkb": "B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Lymphocyte antigen 57; Slp-65; Src homology 2 domain-containing leukocyte protein of 65 kDa", "protein_names_refseq": "B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein isoform 1; B-cell linker protein; cytoplasmic adapter protein; lymphocyte antigen 57; src homology 2 domain-containing leukocyte protein of 65 kDa", "tax_id": 10090, "disease": "agammaglobulinemia 4 (Disease Ontology:DOID:0060027); agammaglobulinemia (Disease Ontology:DOID:2583)", "pathway": " (mmu:17060); (R-MMU-983695)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11449366;11859098;11909947;12761551;18369315;21750661;21930792;26495903;28290451;33416167;39413134;9697839;9705962", "class_list": "", "function": "BLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration., [RefSeq, PubMed]; Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis., [UniProtKB, PubMed, PubMed, PubMed]; Involvement of Blnk and Foxo1 in tumor suppression in BCRABL1transformed proB cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88504", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0008289 lipid binding;GO:0042169 SH2 domain binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010628 positive regulation of gene expression;GO:0035556 intracellular signal transduction;GO:0042113 B cell activation;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QUN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13634-1", "uniprot_id": "CAH1_MOUSE", "mass": 28331.0, "length": 261, "protein_name": "Carbonic anhydrase 1", "gene_name": "Ca1; Car1", "organism": "Mouse", "refseq_name": "carbonic anhydrase 1", "refseq_ac": "NP_001077426", "gene_names_uniprotkb": "Ca1; Car1; Car1", "gene_names_refseq": "Ca1; Car-1; Car1", "protein_names_uniprotkb": "Carbonic anhydrase 1; 4.2.1.1; 4.2.1.69; CA-I; Carbonate dehydratase I; Carbonic anhydrase I; Cyanamide hydratase CA1", "protein_names_refseq": "CA-I; carbonate dehydratase I; carbonic anhydrase 1; carbonic anhydrase I; cyanamide hydratase CA1", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colitis (Disease Ontology:DOID:0060180); Graves ophthalmopathy (Disease Ontology:DOID:0081120); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); major depressive disorder (Disease Ontology:DOID:1470); viral hepatitis (Disease Ontology:DOID:1884); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:12346); (R-MMU-1237044); (R-MMU-1247673); (R-MMU-1475029)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "21750661;2571923;26495903;28011936;3104601;34428180;37013604;37507081;39927985", "class_list": "", "function": "Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB]; Upregulation of carbonic anhydrase 1 beneficial for depressive disorder. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS19;Q9DC84", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004064 arylesterase activity;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009750 response to fructose", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P13634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES30-1", "uniprot_id": "C1QT3_MOUSE", "mass": 26828.0, "length": 246, "protein_name": "Complement C1q tumor necrosis factor-related protein 3", "gene_name": "C1qtnf3", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 3 isoform 2 precursor", "refseq_ac": "NP_112150", "gene_names_uniprotkb": "C1qtnf3; Cors26; Ctrp3", "gene_names_refseq": "2310005P21Rik; Adim; C1qtnf3; CORS-26; CORS26; CTRP3; Corcs; Cors", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 3; CORS26; Collagenous repeat-containing sequence 26 kDa protein; Secretory protein CORS26", "protein_names_refseq": "adiponectin m; cartducin; cartonectin; collagenous repeat-containing sequence 26 kDa protein; complement C1q tumor necrosis factor-related protein 3 isoform 2 precursor; complement C1q tumor necrosis factor-related protein 3; secretory protein CORS26", "tax_id": 10090, "disease": "", "pathway": " (mmu:81799)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11071891;12850274;15157741;21750661;37422777;38818814", "class_list": "", "function": "CTRP3 regulates NF-kappaB and TGFbeta1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA. Publication Status: Online-Only, [RefSeq, PubMed]; GCTRP3 inhibits oophorectomy-induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice., [RefSeq, PubMed]; Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26, [RefSeq, PubMed]; The murine CORS-26 promoter is transcriptionally regulated by specificity protein-1, PPARgamma, and pituitary protein transcription factor-1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0032991 protein-containing complex", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ES30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z291-1", "uniprot_id": "CAHM1_MOUSE", "mass": 38827.0, "length": 348, "protein_name": "Calcium homeostasis modulator protein 1", "gene_name": "Calhm1", "organism": "Mouse", "refseq_name": "calcium homeostasis modulator protein 1", "refseq_ac": "NP_001074740", "gene_names_uniprotkb": "Calhm1", "gene_names_refseq": "Calhm1; EG546729", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 1", "protein_names_refseq": "calcium homeostasis modulator protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:546729)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "22711817;22723178;23300080;23345406;23467090;28734079;29681531;30804437;33788965;34998826;38761122", "class_list": "", "function": "CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception, [RefSeq, PubMed]; CALHM1 is an evolutionarily conserved ion channel family that detects membrane voltage and extracellular Ca(2+) levels and plays a role in cortical neuronal excitability and Ca(2+) homeostasis, [RefSeq, PubMed]; Calhm1 was of rare abundance in brain tissues, [RefSeq, PubMed]; Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice., [RefSeq, PubMed]; Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes (PubMed:23467090). With CALHM3 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (PubMed:23467090, PubMed:29681531). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-) (PubMed:22711817, PubMed:28734079, PubMed:29681531, PubMed:33788965). Mediates Ca(2+) influx and downstream activation of the ERK1 and ERK2 cascade in neurons (By similarity). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (By similarity). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins., [RefSeq, PubMed]; The study identifies a previously uncharacterized mechanism of control of Ca(2+)-dependent ERK1/2 signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function., [RefSeq, PubMed]; Ultrastructural localization of calcium homeostasis modulator 1 in mouse taste buds., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;1.8.-.-;2.7.11.1;1.8.5.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005227 calcium-activated cation channel activity;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0005261 monoatomic cation channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0044853 plasma membrane raft;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0006812 monoatomic cation transport;GO:0034765 regulation of monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "D3Z291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08688-1", "uniprot_id": "CAN5_MOUSE", "mass": 72955.0, "length": 640, "protein_name": "Calpain-5", "gene_name": "Capn5", "organism": "Mouse", "refseq_name": "calpain-5", "refseq_ac": "NP_001288179", "gene_names_uniprotkb": "Capn5; Ncl3", "gene_names_refseq": "Capn5; nCL-3", "protein_names_uniprotkb": "Calpain-5; 3.4.22.-; New calpain 3; nCL-3", "protein_names_refseq": "calpain-5; new calpain 3", "tax_id": 10090, "disease": "neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (mmu:12337); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14749380;14981075;20485683;21750661;26495903;33607190;37949151;9339374;9503024", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB]; Calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis, [RefSeq, PubMed]; Characterization of mitochondrial calpain-5., [RefSeq, PubMed]; Despite the numerous expression sites of Capn5, the majority of Capn5-null mice were viable and fertile and appeared healthy, [RefSeq, PubMed]; Role of calpain-5 in cerebral ischemia and reperfusion injury., [RefSeq, PubMed]; The protein encoded by this gene is a member of the calpain family of proteins. Unlike many members of the calpain gene family, this gene lacks a calmodulin-like domain, required for calcium binding. Mouse models for Huntington's disease displayed increased levels of the protein encoded by this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91YU0", "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D805-1", "uniprot_id": "CAN9_MOUSE", "mass": 78977.0, "length": 690, "protein_name": "Calpain-9", "gene_name": "Capn9", "organism": "Mouse", "refseq_name": "calpain-9", "refseq_ac": "NP_076198", "gene_names_uniprotkb": "Capn9; Ncl4", "gene_names_refseq": "2200003B16Rik; Capn9; GC36; nCL-4; nCL4", "protein_names_uniprotkb": "Calpain-9; 3.4.22.-; Digestive tract-specific calpain; New calpain 4; nCL-4", "protein_names_refseq": "calpain-9; digestive tract-specific calpain; new calpain 4", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:73647); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31316008;9524069", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB]; These data provide a strong signature for tolerance of therapeutic strategies for fibrosis aimed at CAPN9 antagonism., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNM7;O35919", "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54940-1", "uniprot_id": "BNIP2_MOUSE", "mass": 37769.0, "length": 326, "protein_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2", "gene_name": "Bnip2", "organism": "Mouse", "refseq_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform beta", "refseq_ac": "NP_058067", "gene_names_uniprotkb": "Bnip2; Nip2l", "gene_names_refseq": "5730523P12Rik; BNIP2beta; Bnip2; Nip21", "protein_names_uniprotkb": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2", "protein_names_refseq": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform beta; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; BCL2/adenovirus E1B 19 kDa-interacting protein 2 beta; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B interacting protein 1, NIP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12175); (R-MMU-525793)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12089062;17242355;19144319;21183079;21750661", "class_list": "", "function": "Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4H0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0045666 positive regulation of neuron differentiation;GO:0006915 apoptotic process;GO:0051146 striated muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TMW1-1", "uniprot_id": "C102A_MOUSE", "mass": 62624.0, "length": 549, "protein_name": "Coiled-coil domain-containing protein 102A", "gene_name": "Ccdc102a", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 102A", "refseq_ac": "NP_001028705", "gene_names_uniprotkb": "Ccdc102a", "gene_names_refseq": "Ccdc102a; Gm586", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 102A", "protein_names_refseq": "coiled-coil domain-containing protein 102A", "tax_id": 10090, "disease": "", "pathway": " (mmu:234582)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AUL1;Q3B7Y4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016459 myosin complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TMW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVD7-1", "uniprot_id": "C1QT7_MOUSE", "mass": 30517.0, "length": 289, "protein_name": "Complement C1q tumor necrosis factor-related protein 7", "gene_name": "C1qtnf7", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 7 isoform a precursor", "refseq_ac": "NP_001128644", "gene_names_uniprotkb": "C1qtnf7; Ctrp7", "gene_names_refseq": "5530401N20Rik; 8430425G24Rik; Adig; C1qtnf7; Ctrp7", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 7", "protein_names_refseq": "C1q and tumor necrosis factor related protein 5; adiponectin g; complement C1q tumor necrosis factor-related protein 7 isoform a precursor; complement C1q tumor necrosis factor-related protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:109323)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;28223291", "class_list": "", "function": "In obese male mice consuming a high-fat diet, CTRP7 deficiency attenuated insulin resistance and enhanced glucose tolerance, independent of body weight, metabolic rate, and physical activity level. Improved glucose metabolism in CTRP7-deficient mice was associated with reduced adipose tissue inflammation, as well as decreased liver fibrosis and cellular oxidative and endoplasmic reticulum stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHX9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BVD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88875-1", "uniprot_id": "BY55_MOUSE", "mass": 20570.0, "length": 185, "protein_name": "CD160 antigen", "gene_name": "Cd160", "organism": "Mouse", "refseq_name": "CD160 antigen isoform a precursor", "refseq_ac": "NP_001156968", "gene_names_uniprotkb": "Cd160; By55", "gene_names_refseq": "By55; Cd160", "protein_names_uniprotkb": "CD160 antigen; Natural killer cell receptor BY55", "protein_names_refseq": "CD160 antigen isoform a precursor; natural killer cell BY55; natural killer cell receptor BY55", "tax_id": 10090, "disease": "", "pathway": " (mmu:54215); (R-MMU-198933)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16177084;16764942;18193050;21750661;22801499;25711213;33072082;34461306;9743336", "class_list": "", "function": "CD160 Plays a Protective Role During Chronic Infection by Enhancing Both Functionalities and Proliferative Capacity of CD8+ T Cells. Publication Status: Online-Only, [RefSeq, PubMed]; CD160 is expressed on the majority of CD8(+) memory T cells as well as recently activated CD8(+) T cells, [RefSeq, PubMed]; Knockout Mice BALB C Mice C3H Mice F344 Rats K562 Cells Cultured Cells, [RefSeq, PubMed]; Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (By similarity). Receptor for both classical and non-classical MHC class I molecules (PubMed:16177084). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (PubMed:25711213). On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (PubMed:22801499)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection., [RefSeq, PubMed]; The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9H4", "ec_number_list": "", "go_molecular_function": "GO:0023024 MHC class I protein complex binding;GO:0032394 MHC class Ib receptor activity;GO:0005102 signaling receptor binding;GO:0019900 kinase binding;GO:0032393 MHC class I receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0031295 T cell costimulation;GO:0002250 adaptive immune response;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88875-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCA5-1", "uniprot_id": "BRX1_MOUSE", "mass": 41241.0, "length": 353, "protein_name": "Ribosome biogenesis protein BRX1 homolog", "gene_name": "Brix1", "organism": "Mouse", "refseq_name": "ribosome biogenesis protein BRX1 homolog", "refseq_ac": "NP_080672", "gene_names_uniprotkb": "Brix1; Brix; Bxdc2", "gene_names_refseq": "1110064N10Rik; Brix1; Bxdc2", "protein_names_uniprotkb": "Ribosome biogenesis protein BRX1 homolog; Brix domain-containing protein 2", "protein_names_refseq": "BRX1, biogenesis of ribosomes, homolog; brix domain containing 2; brix domain-containing protein 2; ribosome biogenesis protein BRX1 homolog; ribosome biogenesis protein Brix", "tax_id": 10090, "disease": "", "pathway": " (mmu:67832)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;21952136;25428506;30084848;30779550;34428180", "class_list": "", "function": "Required for biogenesis of the 60S ribosomal subunit., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THD3;Q91YS6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R016-1", "uniprot_id": "BLMH_MOUSE", "mass": 52511.0, "length": 455, "protein_name": "Bleomycin hydrolase", "gene_name": "Blmh", "organism": "Mouse", "refseq_name": "bleomycin hydrolase", "refseq_ac": "NP_848760", "gene_names_uniprotkb": "Blmh", "gene_names_refseq": "Bh; Blmh; Bmh", "protein_names_uniprotkb": "Bleomycin hydrolase; 3.4.22.40; BH; BLM hydrolase; BMH", "protein_names_refseq": "BLM hydrolase; bleomycin hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:104184); (R-MMU-983168)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12140188;17513741;21750661;22227865;23806337;24913063;25428506;26495903;26740625;28011936;31219806;32069316;34428180;37718819;39927985", "class_list": "", "function": "BH does not play a major role either in generating or destroying class I major histocompatibility antigen (MHC)-presented peptides that bind to the MHC in living cells. These results point to redundant functions between peptidases., [RefSeq, PubMed]; Bleomycin hydrolase functions as an MHC class I epitope-processing protease, [RefSeq, PubMed]; Bleomycin hydrolase protects against neurodegeneration associated with elevated homocysteine thiolactone levels in hyperhomocysteinemia and Alzheimer's disease., [RefSeq, PubMed]; Blmh interacts with diverse cellular processes--lipoprotein, amino acid and protein, carbohydrate, and energy metabolisms, detoxification, antioxidant defenses--that are essential for normal kidney homeostasis., [RefSeq, PubMed]; Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease., [RefSeq, PubMed]; The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]., [RefSeq]; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJR8;Q8BLZ4;Q8BZH9;Q8C111;Q8CID9", "ec_number_list": "3.4.11.-;3.4.11.14;3.4.14.10;3.4.11.3;3.4.22.40", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004177 aminopeptidase activity;GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0009636 response to toxic substance;GO:0009410 response to xenobiotic stimulus;GO:0043418 homocysteine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8R016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JU7-1", "uniprot_id": "BNIPL_MOUSE", "mass": 36785.0, "length": 328, "protein_name": "Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein", "gene_name": "Bnipl", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Bnipl", "gene_names_refseq": "", "protein_names_uniprotkb": "Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:171388)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q923E3", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0040009 regulation of growth rate", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99JU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39038-1", "uniprot_id": "CADH4_MOUSE", "mass": 100030.0, "length": 913, "protein_name": "Cadherin-4", "gene_name": "Cdh4", "organism": "Mouse", "refseq_name": "cadherin-4 isoform 1 preproprotein", "refseq_ac": "NP_033997", "gene_names_uniprotkb": "Cdh4", "gene_names_refseq": "Cdh4; R-CAD; R-Cadh; Rcad", "protein_names_uniprotkb": "Cadherin-4; R-CAD; R-cadherin; Retinal cadherin", "protein_names_refseq": "R-cadherin; cadherin-4 isoform 1 preproprotein; retina cadherin; retinal cadherin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12561); (R-MMU-418990); (R-MMU-525793)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;8247017;8270638", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development., [UniProtKB]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. The encoded protein is involved in retinal angiogenesis during development where it plays a crucial role in the endothelial-astrocyte interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 11, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P39038-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24288-1", "uniprot_id": "BCAT1_MOUSE", "mass": 42791.0, "length": 386, "protein_name": "Branched-chain-amino-acid aminotransferase, cytosolic", "gene_name": "Bcat1", "organism": "Mouse", "refseq_name": "branched-chain-amino-acid aminotransferase, cytosolic isoform 2", "refseq_ac": "NP_031558", "gene_names_uniprotkb": "Bcat1; Eca39", "gene_names_refseq": "BCATc; Bcat1; Eca39", "protein_names_uniprotkb": "Branched-chain-amino-acid aminotransferase, cytosolic; 2.6.1.42; BCAT(c)", "protein_names_refseq": "BCAT(c); branched-chain-amino-acid aminotransferase, cytosolic isoform 2; branched-chain-amino-acid aminotransferase, cytosolic", "tax_id": 10090, "disease": "amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:12035); (R-MMU-70895)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;2251142;25153642;31219806;36260995;36965015;38369471;8692959", "class_list": "", "function": "BCAT1 redox function maintains mitotic fidelity. Erratum:[Cell Rep. 2023 Mar 28;42(3):112217. doi: 10.1016/j.celrep.2023.112217. PMID: 36862549], [RefSeq, PubMed]; Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2[-/-] tumor cell line., [RefSeq, PubMed]; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMT2", "ec_number_list": "2.6.1.42", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004084 branched-chain-amino-acid transaminase activity;GO:0052654 L-leucine-2-oxoglutarate transaminase activity;GO:0052655 L-valine-2-oxoglutarate transaminase activity;GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0009098 L-leucine biosynthetic process;GO:0009099 L-valine biosynthetic process;GO:0008652 amino acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P24288-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZB0-1", "uniprot_id": "C560_MOUSE", "mass": 18382.0, "length": 169, "protein_name": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "gene_name": "Sdhc", "organism": "Mouse", "refseq_name": "succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor", "refseq_ac": "NP_079597", "gene_names_uniprotkb": "Sdhc", "gene_names_refseq": "0610010E03Rik; Sdhc", "protein_names_uniprotkb": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Integral membrane protein CII-3; Malate dehydrogenase [quinone] cytochrome b560 subunit; QPs-1; QPs1", "protein_names_refseq": "QPs-1; QPs1; integral membrane protein CII-3; malate dehydrogenase [quinone] cytochrome b560 subunit; succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor; succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "tax_id": 10090, "disease": "paraganglioma (Disease Ontology:DOID:0050773); pheochromocytoma/paraganglioma syndrome 3 (Disease Ontology:DOID:0061218); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); Leigh disease (Disease Ontology:DOID:3652); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (mmu:66052); (R-MMU-71403); (R-MMU-9854311)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12676762;12925748;21750661;25428506;34428180;36288343;37453647", "class_list": "", "function": "A sensor for apoptosis induction, [RefSeq, PubMed]; Complex II plays an essential role in hypoxic reactive oxygen species production., [RefSeq, PubMed]; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q544Q9;Q99JP2;Q9DCU7", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045273 respiratory chain complex II (succinate dehydrogenase);GO:0016020 membrane", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CZB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08532-1", "uniprot_id": "CA2D1_MOUSE", "mass": 124630.0, "length": 1103, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-1", "gene_name": "Cacna2d1", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel subunit alpha-2/delta-1 isoform a preproprotein", "refseq_ac": "NP_001104313", "gene_names_uniprotkb": "Cacna2d1; Cacna2", "gene_names_refseq": "Ca(v)alpha2delta1; Cacna2d1; Cacna2; Cchl2a", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1", "protein_names_refseq": "dihydropyridine-sensitive calcium channel alpha 2; voltage-dependent calcium channel alpha2/delta-1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform a preproprotein; voltage-dependent calcium channel subunit alpha-2/delta-1; voltage-gated calcium channel subunit alpha-2/delta-1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 110 (Disease Ontology:DOID:0070395); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:12293)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16452087;1847144;19349973;19656770;30899004;31219806;33300544;34428180;36210013;39927985;8955374", "class_list": "", "function": "The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity). Plays an important role in excitation-contraction coupling (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]; This study of the rabbit ortholog of dihydropyridine-sensitive calcium channel alpha 2 provides N-terminal sequencing evidence of the cleavage junction of the alpha2 and delta subunits from the preprotein, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 20, "disease_count": 3, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "O08533;O08534;O08535;O08536", "ec_number_list": "", "go_molecular_function": "GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential;GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098992 neuronal dense core vesicle;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0086048 membrane depolarization during bundle of His cell action potential;GO:1904646 cellular response to amyloid-beta;GO:0006816 calcium ion transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "O08532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35127-1", "uniprot_id": "C10_MOUSE", "mass": 13194.0, "length": 126, "protein_name": "Protein C10", "gene_name": "Grcc10", "organism": "Mouse", "refseq_name": "protein C10", "refseq_ac": "NP_038563", "gene_names_uniprotkb": "Grcc10; C10", "gene_names_refseq": "2310033H05Rik; C10; Grcc10", "protein_names_uniprotkb": "Protein C10", "protein_names_refseq": "B-cell receptor-associated protein 37; protein C10", "tax_id": 10090, "disease": "Temtamy syndrome (Disease Ontology:DOID:0111621)", "pathway": " (mmu:14790)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "18299400;19224205;20173027;21952136;22872234;23453665;25428506;30084848;32152506;34428180;35820727;35984892;36210013;37828378", "class_list": "", "function": "In brain, may be required for corpus callosum development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545G8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0050890 cognition;GO:0009791 post-embryonic development;GO:0048593 camera-type eye morphogenesis;GO:0014819 regulation of skeletal muscle contraction;GO:0021540 corpus callosum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O35127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35350-1", "uniprot_id": "CAN1_MOUSE", "mass": 82106.0, "length": 713, "protein_name": "Calpain-1 catalytic subunit", "gene_name": "Capn1", "organism": "Mouse", "refseq_name": "calpain-1 catalytic subunit", "refseq_ac": "NP_001103974", "gene_names_uniprotkb": "Capn1; Canp1; Capa1", "gene_names_refseq": "Capa-1; Capa1; Capn1; mu-calpin", "protein_names_uniprotkb": "Calpain-1 catalytic subunit; 3.4.22.52; CANP 1; Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-calpain; muCANP", "protein_names_refseq": "CANP 1; calcium-activated neutral proteinase 1; calpain mu-type; calpain-1 catalytic subunit; calpain-1 large subunit; micromolar-calpain; mu-calpain; muCANP", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); aortic atherosclerosis (Disease Ontology:DOID:10230); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); epilepsy (Disease Ontology:DOID:1826); hereditary spastic paraplegia (Disease Ontology:DOID:2476); acute kidney failure (Disease Ontology:DOID:3021); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12333); (R-MMU-1474228); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16452087;21750661;26495903;26740625;31219806;31599954;34428180;37602925;39927985", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'. Cleaves and activates caspase-7 (CASP7)., [UniProtKB, UniProtKB]; Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88666", "ec_number_list": "2.4.1.25;3.2.1.33;3.4.22.53;3.4.22.-;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.12;2.7.10.2;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;3.4.22.54;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding;GO:0008092 cytoskeletal protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006508 proteolysis;GO:0050790 regulation of catalytic activity;GO:0070301 cellular response to hydrogen peroxide;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35350-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54905-1", "uniprot_id": "B3GT2_MOUSE", "mass": 49095.0, "length": 422, "protein_name": "Beta-1,3-galactosyltransferase 2", "gene_name": "B3galt2", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyltransferase 2", "refseq_ac": "NP_064409", "gene_names_uniprotkb": "B3galt2", "gene_names_refseq": "B3galt2", "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 2; 2.4.1.86; Beta-1,3-GalTase 2; Beta3Gal-T2; Beta3GalT2; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-II", "protein_names_refseq": "UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-II; beta-1,3-GalTase 2; beta-1,3-galactosyltransferase 2; beta3Gal-T2; beta3GalT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26878); (R-MMU-9037629)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;33482286;33524473;35820727;36504040;9417047", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1, 3-galactosyltransferase 2 ameliorates focal ischemic cerebral injury by maintaining blood-brain barrier integrity., [RefSeq, PubMed]; Beta-1, 3-galactosyltransferase 2 deficiency exacerbates brain injury after transient focal cerebral ischemia in mice., [RefSeq, PubMed]; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins., [UniProtKB, PubMed]; Effects of the genetic knockout of the beta-1,3-galactosyltransferase 2 on spatial learning and neurons in the adult mouse hippocampus and somatosensory cortex., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 9552, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH19;Q8CBX4;Q91V19;Q91V58;Q91VE9;Q920V3;Q920V4", "ec_number_list": "2.4.1.86;2.4.1.-;2.4.1.62", "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006682 galactosylceramide biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0006678 glucosylceramide metabolic process", "synthesized_glycan_count": 790, "hit_score": 0.9, "record_id": "O54905-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88870-1", "uniprot_id": "BEST1_MOUSE", "mass": 63684.0, "length": 551, "protein_name": "Bestrophin-1", "gene_name": "Best1", "organism": "Mouse", "refseq_name": "bestrophin-1", "refseq_ac": "NP_036043", "gene_names_uniprotkb": "Best1; Bmd1; Vmd2", "gene_names_refseq": "Best1; Bmd; Vmd2; mBest1", "protein_names_uniprotkb": "Bestrophin-1; Vitelliform macular dystrophy protein 2 homolog", "protein_names_refseq": "best macular dystrophy; bestrophin-1; vitelliform macular dystrophy 2 homolog; vitelliform macular dystrophy protein 2 homolog", "tax_id": 10090, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); bestrophinopathy (Disease Ontology:DOID:0050662); retinitis pigmentosa 50 (Disease Ontology:DOID:0110396); autosomal dominant vitreoretinochoroidopathy (Disease Ontology:DOID:0111569); macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (mmu:24115); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15218265;20929730;21750661;23021213;25428506;25645137;29121962;34952697;9662395", "class_list": "", "function": "Cloning and characterization by combining biocomputational analyses and molecular genetic approaches, [RefSeq, PubMed]; Forms calcium-sensitive chloride channels. Permeable to bicarbonate., [UniProtKB, UniProtKB]; Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (By similarity). Allows the movement of chloride and hydrogencarbonate (By similarity). Found in a partially open conformation leading to significantly smaller chloride movement (By similarity). Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (PubMed:23021213, PubMed:25645137, PubMed:29121962). Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition (PubMed:34952697). Releases the 4-aminobutanoate neurotransmitter in a (Ca2+)-dependent manner, and participates in its tonic release from cerebellar glial cells (PubMed:20929730)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSY6;Q6H1V0", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity;GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0034707 chloride channel complex;GO:0009925 basal plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0048167 regulation of synaptic plasticity;GO:0051924 regulation of calcium ion transport;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88870-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14106-1", "uniprot_id": "C1QB_MOUSE", "mass": 26717.0, "length": 253, "protein_name": "Complement C1q subcomponent subunit B", "gene_name": "C1qb", "organism": "Mouse", "refseq_name": "complement C1q subcomponent subunit B precursor", "refseq_ac": "NP_033907", "gene_names_uniprotkb": "C1qb", "gene_names_refseq": "Adia; C1qb", "protein_names_uniprotkb": "Complement C1q subcomponent subunit B", "protein_names_refseq": "adiponectin a; complement C1q subcomponent subunit B precursor; complement C1q subcomponent subunit B", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); severe acute respiratory syndrome (Disease Ontology:DOID:2945); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (mmu:12260); (R-MMU-173623); (R-MMU-977606)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "2591537;30084848;30779550;3258283;33300544;34428180;6286235;8606057", "class_list": "", "function": "Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U793", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0048839 inner ear development;GO:0098883 synapse pruning;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P14106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51437-1", "uniprot_id": "CAMP_MOUSE", "mass": 19453.0, "length": 172, "protein_name": "Cathelicidin antimicrobial peptide", "gene_name": "Camp", "organism": "Mouse", "refseq_name": "cathelicidin antimicrobial peptide precursor", "refseq_ac": "NP_034051", "gene_names_uniprotkb": "Camp; Cnlp; Cramp", "gene_names_refseq": "CAP18; CLP; Camp; Cnlp; Cramp; FALL39; MCLP", "protein_names_uniprotkb": "Cathelicidin antimicrobial peptide; CLP; Cathelin-like protein", "protein_names_refseq": "cathelicidin antimicrobial peptide precursor; cathelin-like protein; cathelin-related antimicrobial peptide", "tax_id": 10090, "disease": "dentin caries (Disease Ontology:DOID:10461); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:12796); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11719807;12081622;22879591;34428180;8706928;9148921", "class_list": "", "function": "Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2., [UniProtKB, PubMed]; An important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS)., [RefSeq, PubMed]; Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity)., [UniProtKB, UniProtKB]; Solution structure in TFE/H2O solution determined by CD and NMR spectroscopy, [RefSeq, PubMed]; This gene encodes a member of the cathelicidin family of antimicrobial peptides that play an important role in the defense against microbial infection. The encoded preproprotein undergoes proteolytic processing to generate a mature polypeptide before secretion by host cells such as neutrophils, epithelial cells and macrophages. Mice lacking the encoded protein exhibit increased susceptibility to group A streptococcus and Escherichia coli infections. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB78", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0042581 specific granule;GO:0042995 cell projection", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0097187 dentinogenesis;GO:0002760 positive regulation of antimicrobial humoral response;GO:0001878 response to yeast;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51437-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58545-1", "uniprot_id": "BTBD3_MOUSE", "mass": 58802.0, "length": 530, "protein_name": "BTB/POZ domain-containing protein 3", "gene_name": "Btbd3", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 3 isoform 2", "refseq_ac": "NP_001020602", "gene_names_uniprotkb": "Btbd3", "gene_names_refseq": "Btbd3; mKIAA0952", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 3", "protein_names_refseq": "BTB (POZ) domain containing 3; BTB/POZ domain-containing protein 3 isoform 2; BTB/POZ domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:228662)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24179155;31219806;31501410;31599954", "class_list": "", "function": "Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed., [UniProtKB, PubMed]; During the development of the sensory cortex, dendritic field orientation is controlled by the BTB/POZ domain-containing 3 (BTBD3)., [RefSeq, PubMed]; Our findings reveal that hippocampal Btbd3 expression selectively modulates compulsive-like and exploratory behavior Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5B8", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0021987 cerebral cortex development;GO:0048813 dendrite morphogenesis;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P58545-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1T3-1", "uniprot_id": "BRM1L_MOUSE", "mass": 37657.0, "length": 323, "protein_name": "Breast cancer metastasis-suppressor 1-like protein", "gene_name": "Brms1l", "organism": "Mouse", "refseq_name": "breast cancer metastasis-suppressor 1-like protein", "refseq_ac": "NP_001032845", "gene_names_uniprotkb": "Brms1l", "gene_names_refseq": "0710008O11Rik; BRMS1; Brms1l; D12Ertd407e", "protein_names_uniprotkb": "Breast cancer metastasis-suppressor 1-like protein", "protein_names_refseq": "breast cancer metastasis-suppressor 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:52592)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23211523;31219806", "class_list": "", "function": "Findings indicate the expression of Brms1L depends on beta-catenin activity and contributes to follicle stimulating hormone beta induction by Gonadotropin-Releasing Hormone., [RefSeq, PubMed]; Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZX8", "ec_number_list": "", "go_molecular_function": "GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070822 Sin3-type complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U1T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UW68-1", "uniprot_id": "CAN13_MOUSE", "mass": 76049.0, "length": 665, "protein_name": "Calpain-13", "gene_name": "Capn13", "organism": "Mouse", "refseq_name": "calpain-13", "refseq_ac": "NP_001028616", "gene_names_uniprotkb": "Capn13; Gm943", "gene_names_refseq": "CANP 13; Capn13; Gm943", "protein_names_uniprotkb": "Calpain-13; 3.4.22.-; CANP 13; Calcium-activated neutral proteinase 13", "protein_names_refseq": "calcium-activated neutral proteinase 13; calpain-13", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:381122); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "Probable non-lysosomal thiol-protease., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW21", "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UW68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497V6-1", "uniprot_id": "BAHD1_MOUSE", "mass": 83871.0, "length": 772, "protein_name": "Bromo adjacent homology domain-containing 1 protein", "gene_name": "Bahd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Bahd1; Gm117; Kiaa0945", "gene_names_refseq": "", "protein_names_uniprotkb": "Bromo adjacent homology domain-containing 1 protein; BAH domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:228536)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;27802388;34428180", "class_list": "", "function": "Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQV1;A6PWW9;B2RUB2;B7ZNH0;Q6ZQ21;Q80VH7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0005677 chromatin silencing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q497V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4ZJN1-1", "uniprot_id": "C1QT9_MOUSE", "mass": 34566.0, "length": 333, "protein_name": "Complement C1q and tumor necrosis factor-related protein 9", "gene_name": "C1qtnf9", "organism": "Mouse", "refseq_name": "complement C1q and tumor necrosis factor-related protein 9 precursor", "refseq_ac": "NP_898998", "gene_names_uniprotkb": "C1qtnf9", "gene_names_refseq": "9130217G22Rik; Adif1; C1qtnf9; CTRP9; Ciqtnf9", "protein_names_uniprotkb": "Complement C1q and tumor necrosis factor-related protein 9", "protein_names_refseq": "adiponectin f1; complement C1q and tumor necrosis factor-related protein 9 precursor; complement C1q and tumor necrosis factor-related protein 9; complement C1q tumor necrosis factor-related protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:239126)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15231994;18787108;21836066;22514273;37945738;38348774;38741428;38940054", "class_list": "", "function": "A novel and highly conserved paralog of adiponectin designated as C1q/TNF-related protein (CTRP) 9 is characterized., [RefSeq, PubMed]; C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel Vasculoprotective Cytokine That Restores High Glucose-Suppressed Endothelial Progenitor Cell Functions by Activating the Endothelial Nitric Oxide Synthase., [RefSeq, PubMed]; CTRP 9 mitigates the apoptosis and unfolded protein response of OGD/R-induced retinal ganglion cells by regulating the AMPK pathway., [RefSeq, PubMed]; CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet., [RefSeq, PubMed]; CTRP9 protects against acute cardiac injury following ischemia-reperfusion via an AMPK-dependent mechanism., [RefSeq, PubMed]; Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress. Publication Status: Online-Only, [RefSeq, PubMed]; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways., [UniProtKB, PubMed]; We have provided the first evidence that CTRP9 is a novel vasorelaxative adipocytokine that may exert vasculoprotective effects via the adiponectin receptor 1/AMPK/eNOS dependent/NO mediated signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZS3", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0097009 energy homeostasis;GO:0019395 fatty acid oxidation;GO:0071902 positive regulation of protein serine/threonine kinase activity;GO:0045792 negative regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q4ZJN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTM8-1", "uniprot_id": "BRE1A_MOUSE", "mass": 113520.0, "length": 973, "protein_name": "E3 ubiquitin-protein ligase BRE1A", "gene_name": "Rnf20", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase BRE1A isoform 1", "refseq_ac": "NP_001156735", "gene_names_uniprotkb": "Rnf20; Bre1a; Kiaa4116", "gene_names_refseq": "4833430L21Rik; Rnf20; mKIAA4116", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase BRE1A; 2.3.2.27; BRE1-A; RING finger protein 20; RING-type E3 ubiquitin transferase BRE1A", "protein_names_refseq": "BRE1-A; E3 ubiquitin-protein ligase BRE1A isoform 1; E3 ubiquitin-protein ligase BRE1A; RING-type E3 ubiquitin transferase BRE1A", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:109331); (R-MMU-8866654); (R-MMU-9013422)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "20738173;21183079;21750661;21952136;28453857;30016717;34428180;38296968;39322771", "class_list": "", "function": "Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1) (PubMed:28453857). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation., [UniProtKB, UniProtKB, PubMed]; RNF20-mediated transcriptional pausing and VEGFA splicing orchestrate vessel growth., [RefSeq, PubMed]; The observed defects in the radiation response of Bre1a/b-deficient cells, [RefSeq, PubMed]; Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AIR3;Q3UT10;Q3V350;Q7TT11;Q8BKA8;Q8BKN8;Q8BUF7;Q8BVU4", "ec_number_list": "2.3.2.23;2.7.11.39;3.6.1.-;2.3.2.27;3.1.4.-;3.1.4.35;2.7.11.1;3.6.5.2", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000151 ubiquitin ligase complex;GO:0033503 HULC complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0030336 negative regulation of cell migration;GO:0045893 positive regulation of DNA-templated transcription;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5DTM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5IR70-1", "uniprot_id": "CAGE1_MOUSE", "mass": 97035.0, "length": 849, "protein_name": "Cancer-associated gene 1 protein homolog", "gene_name": "Cage1", "organism": "Mouse", "refseq_name": "cancer-associated gene 1 protein homolog", "refseq_ac": "NP_082000", "gene_names_uniprotkb": "Cage1; Ctag3", "gene_names_refseq": "4933427I01Rik; Cage1; Ctag3", "protein_names_uniprotkb": "Cancer-associated gene 1 protein homolog; CAGE-1; CT3 homolog; Cancer/testis antigen 3 homolog", "protein_names_refseq": "CAGE-1; CT3 homolog; cancer-associated gene 1 protein homolog; cancer/testis antigen 3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71213)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15819420;19322522;21750661;25428506;34428180", "class_list": "", "function": "CAGE was shown to protect cells against celastrol, an anti-cancer agent., [RefSeq, PubMed]; Novel component of the acrosome of mammalian spermatids and spermatozoa, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6X913;Q640N7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5IR70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1S0-1", "uniprot_id": "B9D1_MOUSE", "mass": 22592.0, "length": 204, "protein_name": "B9 domain-containing protein 1", "gene_name": "B9d1", "organism": "Mouse", "refseq_name": "B9 domain-containing protein 1 isoform 2", "refseq_ac": "NP_001317709", "gene_names_uniprotkb": "B9d1; Eppb9", "gene_names_refseq": "B9d1; B9; Eppb9", "protein_names_uniprotkb": "B9 domain-containing protein 1; Endothelial precursor cells protein B9", "protein_names_refseq": "B9 domain-containing protein 1 isoform 2; B9 domain-containing protein 1; endothelial precursor cells protein B9", "tax_id": 10090, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Joubert syndrome 27 (Disease Ontology:DOID:0110996); nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (mmu:27078); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15625703;21565611;21725307;21750661;21763481;22179047", "class_list": "", "function": "B9d1 is required for normal Hh signaling, ciliogenesis, and ciliary protein localization. B9d1 and B9d2 are essential components of a B9 protein complex, disruption of which causes Meckel syndrome. Erratum:[Am J Hum Genet. 2011 Oct 7;89(4):589. Zaghloul, Norran A [corrected to Zaghloul, Norann A]], [RefSeq, PubMed]; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008158 hedgehog receptor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0016020 membrane;GO:0036038 MKS complex;GO:0036064 ciliary basal body;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0032880 regulation of protein localization;GO:0060271 cilium assembly;GO:0060563 neuroepithelial cell differentiation;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R1S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SQY2-1", "uniprot_id": "BOD1_MOUSE", "mass": 18364.0, "length": 173, "protein_name": "Biorientation of chromosomes in cell division protein 1", "gene_name": "Bod1", "organism": "Mouse", "refseq_name": "biorientation of chromosomes in cell division protein 1", "refseq_ac": "NP_001020090", "gene_names_uniprotkb": "Bod1; Fam44b", "gene_names_refseq": "2310022M17Rik; BOD2.1; Bod1; Bodq1; Fam44b", "protein_names_uniprotkb": "Biorientation of chromosomes in cell division protein 1; Biorientation defective protein 1; Protein FAM44B", "protein_names_refseq": "biorientation defective protein 1; biorientation of chromosomes in cell division protein 1; bone length and organs 1; bone length and organs QTL 1; family with sequence similarity 44, member B", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:69556)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051721 protein phosphatase 2A binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005876 spindle microtubule;GO:0048188 Set1C/COMPASS complex;GO:0000940 outer kinetochore", "go_biological_process": "GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SQY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61114-1", "uniprot_id": "BPIB1_MOUSE", "mass": 52455.0, "length": 474, "protein_name": "BPI fold-containing family B member 1", "gene_name": "Bpifb1", "organism": "Mouse", "refseq_name": "BPI fold-containing family B member 1 precursor", "refseq_ac": "NP_001012392", "gene_names_uniprotkb": "Bpifb1; Lplunc1", "gene_names_refseq": "Bpifb1; Lplunc1", "protein_names_uniprotkb": "BPI fold-containing family B member 1; Long palate, lung and nasal epithelium carcinoma-associated protein 1", "protein_names_refseq": "BPI fold-containing family B member 1 precursor; long palate, lung and nasal epithelium carcinoma associated 1; long palate, lung and nasal epithelium carcinoma-associated protein 1; von Ebner minor salivary gland protein; von Ebner minor salivary protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:228801); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14745963;15028288;25428506;28851744;34428180;37847709", "class_list": "", "function": "A novel gene LPlunc1, a member of BPI/PLUNC gene superfamily, which is asymmetrically expressed in the developing mouse node [LPlunc1 protein], [RefSeq, PubMed]; BPIFB1 is a novel regulator of MUC5B expression in airway mucosa., [RefSeq, PubMed]; BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance., [RefSeq, PubMed]; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. May be involved in formation of the left-right axis in the node of the developing embryo., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AJD5;Q497Q1;Q4VC32", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0002227 innate immune response in mucosa;GO:0034144 negative regulation of toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q67E05-1", "uniprot_id": "BPI_MOUSE", "mass": 53940.0, "length": 483, "protein_name": "Bactericidal permeability-increasing protein", "gene_name": "Bpi", "organism": "Mouse", "refseq_name": "bactericidal permeability-increasing protein isoform 1 precursor", "refseq_ac": "NP_808518", "gene_names_uniprotkb": "Bpi", "gene_names_refseq": "9230105K17Rik; Bpifd1; Bpi", "protein_names_uniprotkb": "Bactericidal permeability-increasing protein; BPI", "protein_names_refseq": "bactericidal permeability-increasing protein isoform 1 precursor; bactericidal permeability-increasing protein", "tax_id": 10090, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:329547); (R-MMU-166016); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "15590754;16365446;17483073;18490755;27646594;33109704;33981306", "class_list": "", "function": "Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; Data demonstrate that murine BPI is a potent LPS-neutralizing protein that may limit innate immune responses during Gram-negative infections, [RefSeq, PubMed]; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope., [UniProtKB, PubMed]; The mouse neutrophils store BPI with antibacterial activity and that murine BPI is also expressed in testis and epididymis., [RefSeq, PubMed]; The requirement for C/EBP epsilon in mediating BPI gene expression in myeloid cells in vitro and in vivo., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AC63;Q5I5I4;Q8BSF3", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q67E05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AZB0-1", "uniprot_id": "BOC_MOUSE", "mass": 121331.0, "length": 1110, "protein_name": "Brother of CDO", "gene_name": "Boc", "organism": "Mouse", "refseq_name": "brother of CDO precursor", "refseq_ac": "NP_766094", "gene_names_uniprotkb": "Boc", "gene_names_refseq": "4732455C11; Boc; mFLJ00376", "protein_names_uniprotkb": "Brother of CDO; Protein BOC", "protein_names_refseq": "biregional Cdon binding protein; biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein; brother of CDO precursor; brother of CDO", "tax_id": 10090, "disease": "", "pathway": " (mmu:117606); (R-MMU-525793); (R-MMU-5635838)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11782431;11891987;12634428;15520228;16647303;16647304;17086203;21664576;21750661;33038332;36210013", "class_list": "", "function": "Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells., [UniProtKB, UniProtKB]; Expression of the boc gene during murine embryogenesis, [RefSeq, PubMed]; Together with CDON, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (PubMed:16647303, PubMed:16647304, PubMed:17086203, PubMed:21664576, PubMed:33038332). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (PubMed:33038332). ShhN is then directly transferred to patched receptor by GAS1 (PubMed:33038332). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (PubMed:11782431, PubMed:12634428, PubMed:15520228)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAM5;Q6P5H3;Q7TMJ3;Q8CE73;Q8CE91;Q8R377;Q923W7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0016202 regulation of striated muscle tissue development;GO:0007399 nervous system development;GO:0098609 cell-cell adhesion;GO:0030030 cell projection organization;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6AZB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGH1-1", "uniprot_id": "BUD31_MOUSE", "mass": 17000.0, "length": 144, "protein_name": "Protein BUD31 homolog", "gene_name": "Bud31", "organism": "Mouse", "refseq_name": "protein BUD31 homolog isoform 2", "refseq_ac": "NP_001008705", "gene_names_uniprotkb": "Bud31", "gene_names_refseq": "Bud31; EDG-2; EDG2; G10", "protein_names_uniprotkb": "Protein BUD31 homolog; Protein G10 homolog", "protein_names_refseq": "maternal G10 transcript; protein BUD31 homolog isoform 2; protein BUD31 homolog; protein G10 homolog", "tax_id": 10090, "disease": "schistosomiasis (Disease Ontology:DOID:1395)", "pathway": " (mmu:231889); (R-MMU-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "36114296", "class_list": "", "function": "Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation., [RefSeq, PubMed]; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E0CX20", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005681 spliceosomal complex;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PGH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q766D5-1", "uniprot_id": "B4GN4_MOUSE", "mass": 117373.0, "length": 1034, "protein_name": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1", "gene_name": "B4galnt4", "organism": "Mouse", "refseq_name": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1", "refseq_ac": "NP_808565", "gene_names_uniprotkb": "B4galnt4", "gene_names_refseq": "B4galnt4; Gm1095; NGalNAc-T1; beta4GalNAcT4", "protein_names_uniprotkb": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; 2.4.1.244; Beta-1,4-N-acetylgalactosaminyltransferase IV; Beta4GalNAc-T4; Beta4GalNAcT4; NGalNAc-T1", "protein_names_refseq": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; beta 1,4-N-acetylgalactosaminyltransferase-transferase 4; beta-1,4-N-acetylgalactosaminyltransferase IV; beta1,4-N-acetylgalactosaminyltransferase IV; beta4GalNAc-T4", "tax_id": 10090, "disease": "", "pathway": " (mmu:330671)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15044014;21750661;22722937;22722940", "class_list": "glycogene;glycosyltransferase", "function": "Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 60, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHV2", "ec_number_list": "2.4.1.244", "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0033842 N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 865, "hit_score": 1.0, "record_id": "Q766D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JJ13-1", "uniprot_id": "BRD2_MOUSE", "mass": 88067.0, "length": 798, "protein_name": "Bromodomain-containing protein 2", "gene_name": "Brd2", "organism": "Mouse", "refseq_name": "bromodomain-containing protein 2", "refseq_ac": "NP_001191902", "gene_names_uniprotkb": "Brd2; Fsrg1; Kiaa4005; Ring3", "gene_names_refseq": "Brd2; D17H6S113E; Frg-1; Fsrg-1; Fsrg1; Nat; Ring3; Rnf3; mKIAA4005", "protein_names_uniprotkb": "Bromodomain-containing protein 2; Female sterile homeotic-related protein 1; Fsrg-1", "protein_names_refseq": "bromodomain-containing protein 2; female sterile homeotic-related gene 1", "tax_id": 10090, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); melanoma (Disease Ontology:DOID:1909); photosensitivity disease (Disease Ontology:DOID:3159); juvenile myoclonic epilepsy (Disease Ontology:DOID:4890); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (mmu:14312)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;14731392;17242355;19301389;19883376;21183079;21750661;25428506;26495903;28262505;28388437;34428180;38567724;9528865;9601950;9693039;9811568", "class_list": "", "function": "BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL., [RefSeq, PubMed]; Brd2 autophosphorylation activity is induced in mouse tissues (lung, kidney, brain, liver and heart) upon systemic treatment with the mitogens Epidermal Growth Factor or Phorbol 12-Myristate 13-Acetate., [RefSeq, PubMed]; Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:14731392). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (By similarity). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:28388437). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (By similarity). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9737, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O54795;O88411;Q3UGI0;Q5DTS6;Q794H7;Q794H9;Q99PC5", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0140033 acetylation-dependent protein binding;GO:0140566 histone reader activity;GO:0140011 histone H4K12ac reader activity;GO:0140012 histone H4K5ac reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q7JJ13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSA3-1", "uniprot_id": "BTLA_MOUSE", "mass": 34337.0, "length": 306, "protein_name": "B- and T-lymphocyte attenuator", "gene_name": "Btla", "organism": "Mouse", "refseq_name": "B- and T-lymphocyte attenuator isoform 1 precursor", "refseq_ac": "NP_001032808", "gene_names_uniprotkb": "Btla", "gene_names_refseq": "A630002H24; Btla", "protein_names_uniprotkb": "B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein", "protein_names_refseq": "B- and T-lymphocyte attenuator isoform 1 precursor; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:208154); (R-MMU-9927353)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12796776;14652006;15128774;15568026;15749870;18178834;19915044;21750661;26495903;30084848;30779550;34428180;38418488;38831106;38840336;39269653", "class_list": "", "function": "BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4[+] T-cell exhaustion. Publication Status: Online-Only, [RefSeq, PubMed]; BTLA deficiency promotes HSC activation and protects against hepatic ischemia-reperfusion injury. Erratum:[Hepatol Commun. 2025 Jul 21;9(8):e0761. doi: 10.1097/HC9.0000000000000761. PMID: 40694376] Publication Status: Online-Only, [RefSeq, PubMed]; BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1)., [RefSeq, PubMed]; BTLA is expressed by all mature lymphocytes, splenic macrophages, and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types., [RefSeq, PubMed]; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell Hyperactivity Induced by Branching Deficiency., [RefSeq, PubMed]; The BTLA-HVEM axis restricts CAR T cell efficacy in cancer., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098797 plasma membrane protein complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0042130 negative regulation of T cell proliferation;GO:0002250 adaptive immune response;GO:0070372 regulation of ERK1 and ERK2 cascade;GO:0030889 negative regulation of B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TSA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG79-1", "uniprot_id": "C19L2_MOUSE", "mass": 103173.0, "length": 887, "protein_name": "CWF19-like protein 2", "gene_name": "Cwf19l2", "organism": "Mouse", "refseq_name": "CWF19-like protein 2", "refseq_ac": "NP_081821", "gene_names_uniprotkb": "Cwf19l2", "gene_names_refseq": "3230401L03Rik; 9030209E10; Cwf19l2", "protein_names_uniprotkb": "CWF19-like protein 2", "protein_names_refseq": "CWF19-like 2, cell cycle control; CWF19-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244672); (R-MMU-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;31219806;34428180;38889293", "class_list": "", "function": "CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIS8;Q3UX04;Q80XN7;Q8BZV5;Q8C0F8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BG79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGS2-1", "uniprot_id": "BOLA2_MOUSE", "mass": 10215.0, "length": 86, "protein_name": "BolA-like protein 2", "gene_name": "Bola2", "organism": "Mouse", "refseq_name": "bolA-like protein 2", "refseq_ac": "NP_780312", "gene_names_uniprotkb": "Bola2", "gene_names_refseq": "1110025L05Rik; BolA-2; Bola2", "protein_names_uniprotkb": "BolA-like protein 2", "protein_names_refseq": "bolA-like 2; bolA-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66162)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14718656;35820727", "class_list": "", "function": "Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3., [UniProtKB, UniProtKB]; NMR structure of BolA2 [BolA2], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P601", "ec_number_list": "", "go_molecular_function": "GO:0051537 2 iron, 2 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation;GO:0044571 [2Fe-2S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHX3-1", "uniprot_id": "BOREA_MOUSE", "mass": 32214.0, "length": 289, "protein_name": "Borealin", "gene_name": "Cdca8", "organism": "Mouse", "refseq_name": "borealin", "refseq_ac": "NP_080836", "gene_names_uniprotkb": "Cdca8", "gene_names_refseq": "4831429J16Rik; BOR; Borealin; Cdca8; D4Ertd421e; DasraB; MESRGP", "protein_names_uniprotkb": "Borealin; Cell division cycle-associated protein 8; MESrg", "protein_names_refseq": "MESrg; borealin; cell division cycle-associated protein 8; embryonic stem cell-related", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:52276); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "18311593;21183079;21750661;24463520;37964961", "class_list": "", "function": "Borealin plays a crucial role in the early mouse embryonic development, [RefSeq, PubMed]; Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ARX0;B1ARX1;Q6NVD3;Q8BHB1;Q8BHQ5;Q8BHQ9;Q9CRN4;Q9CS02;Q9CTF4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001934 positive regulation of protein phosphorylation;GO:0000281 mitotic cytokinesis;GO:0007080 mitotic metaphase chromosome alignment;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BHX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJE2-1", "uniprot_id": "BTNL9_MOUSE", "mass": 60549.0, "length": 536, "protein_name": "Butyrophilin-like protein 9", "gene_name": "Btnl9", "organism": "Mouse", "refseq_name": "butyrophilin-like protein 9 precursor", "refseq_ac": "NP_766381", "gene_names_uniprotkb": "Btnl9", "gene_names_refseq": "B430208I01; Btn3; Btnl9; D330012D11Rik", "protein_names_uniprotkb": "Butyrophilin-like protein 9", "protein_names_refseq": "butyrophilin 3; butyrophilin-like protein 9 precursor; butyrophilin-like protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:237754); (R-MMU-8851680)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;30084848;30779550;34428180", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B7ZC64;B9EKA9;Q80V04;Q811T7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BJE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLQ9-1", "uniprot_id": "CADM2_MOUSE", "mass": 47559.0, "length": 435, "protein_name": "Cell adhesion molecule 2", "gene_name": "Cadm2", "organism": "Mouse", "refseq_name": "cell adhesion molecule 2 isoform 2 precursor", "refseq_ac": "NP_001139449", "gene_names_uniprotkb": "Cadm2; Igsf4d; Necl3", "gene_names_refseq": "2900078E11Rik; 9330131D06; A830029E02Rik; Cadm2; Igdf4d; Igsf4d; NECL3; SynCAM 2; SynCAM2", "protein_names_uniprotkb": "Cell adhesion molecule 2; IgSF4D; Immunoglobulin superfamily member 4D; NECL-3; Nectin-like protein 3; SynCAM 2; Synaptic cell adhesion molecule 2", "protein_names_refseq": "NECL-3; cell adhesion molecule 2 isoform 2 precursor; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4; nectin-like protein 3; synaptic cell adhesion molecule 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); malignant astrocytoma (Disease Ontology:DOID:3069); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:239857); (R-MMU-418990)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;20739279;21750661;33300544;37173343;39327467", "class_list": "", "function": "Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1B1A5;B1B1A6;B2RTL0;Q8BXJ7;Q8BYP1;Q8BZP4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0030424 axon;GO:0045211 postsynaptic membrane;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0099560 synaptic membrane adhesion;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BLQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSV3-1", "uniprot_id": "BEND7_MOUSE", "mass": 48451.0, "length": 434, "protein_name": "BEN domain-containing protein 7", "gene_name": "Bend7", "organism": "Mouse", "refseq_name": "BEN domain-containing protein 7 isoform 2", "refseq_ac": "NP_001177329", "gene_names_uniprotkb": "Bend7", "gene_names_refseq": "1110017O21Rik; Bend7; E130319B15Rik", "protein_names_uniprotkb": "BEN domain-containing protein 7", "protein_names_refseq": "BEN domain-containing protein 7 isoform 2; BEN domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:209645)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAD9;Q6PHN3;Q8BPJ4;Q8C973", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BSV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDE2-1", "uniprot_id": "CALI_MOUSE", "mass": 66750.0, "length": 588, "protein_name": "Calicin", "gene_name": "Ccin", "organism": "Mouse", "refseq_name": "calicin", "refseq_ac": "NP_001002787", "gene_names_uniprotkb": "Ccin", "gene_names_refseq": "4933417A14Rik; Ccin", "protein_names_uniprotkb": "Calicin", "protein_names_refseq": "calicin", "tax_id": 10090, "disease": "spermatogenic failure 91 (Disease Ontology:DOID:0070590)", "pathway": " (mmu:442829)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36546111", "class_list": "", "function": "Required for both nuclear and acrosomal shaping during spermiogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0033150 cytoskeletal calyx;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0033011 perinuclear theca", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CDE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFE5-1", "uniprot_id": "BTBD7_MOUSE", "mass": 126243.0, "length": 1130, "protein_name": "BTB/POZ domain-containing protein 7", "gene_name": "Btbd7", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 7", "refseq_ac": "NP_766394", "gene_names_uniprotkb": "Btbd7; Fup1; Kiaa1525", "gene_names_refseq": "5730507E09Rik; 8030448M07; Btbd7; E130118E17Rik; FUP1; mKIAA1525", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 7; Function-unknown protein 1", "protein_names_refseq": "BTB (POZ) domain containing 7; BTB/POZ domain-containing protein 7; function-unkown protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:238386)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11527404;20671187;27369076;30779550;34428180", "class_list": "", "function": "Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression., [UniProtKB, PubMed]; Btbd7 identified as a dynamic regulator of branching morphogenesis; it provides a mechanistic link between extracellular matrix and cleft propagation; Btbd7 is a regulatory gene that promotes epithelial tissue remodeling and formation of branched organs, [RefSeq, PubMed]; On the other hand, cleft formation and branching morphogenesis was suppressed by knockdown of Brachyury gene, suggesting that Brachyury plays a central role in regulating cell growth and cleft formation in early-stage embryonic mouse salivary gland development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TC3;Q8BZY9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0061138 morphogenesis of a branching epithelium;GO:0060693 regulation of branching involved in salivary gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CFE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFG9-1", "uniprot_id": "C1RB_MOUSE", "mass": 79936.0, "length": 706, "protein_name": "Complement C1r-B subcomponent", "gene_name": "C1rb", "organism": "Mouse", "refseq_name": "complement C1r-B subcomponent precursor", "refseq_ac": "NP_001106827", "gene_names_uniprotkb": "C1rb; C1r", "gene_names_refseq": "667277; C1rb; Gm8551; mC1rB", "protein_names_uniprotkb": "Complement C1r-B subcomponent; 3.4.21.41; Complement component 1 subcomponent r-B", "protein_names_refseq": "complement C1r-B subcomponent precursor; complement C1r-B subcomponent; complement component 1 subcomponent r-B; complement component 1, r-B subcomponent; complement component C1rb", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome periodontal type 1 (Disease Ontology:DOID:0080986)", "pathway": " (mmu:667277)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12513694", "class_list": "", "function": "Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0072562 blood microparticle;GO:0005602 complement component C1 complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0045087 innate immune response;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CFG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFR0-1", "uniprot_id": "C1QL2_MOUSE", "mass": 29292.0, "length": 287, "protein_name": "Complement C1q-like protein 2", "gene_name": "C1ql2", "organism": "Mouse", "refseq_name": "complement C1q-like protein 2 precursor", "refseq_ac": "NP_997116", "gene_names_uniprotkb": "C1ql2; C1qtnf10; Ctrp10", "gene_names_refseq": "Adii; C1ql2; CTRP10", "protein_names_uniprotkb": "Complement C1q-like protein 2; C1q and tumor necrosis factor-related protein 10; C1q/TNF-related protein 10; C1qTNF10; CTRP10", "protein_names_refseq": "C1q and tumor necrosis factor-related protein 10; C1q/TNF-related protein 10; C1qTNF10; adiponectin i; complement C1q-like protein 2 precursor; complement C1q-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:226359)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18783346;19996152;21262840;21378161;22351773;23449976", "class_list": "", "function": "Characterization of nCLP2: cDNA sequencing, amino acid sequence, sequence alignment/homology with isoproteins, tissue localization (primarily retina & hippocampus [mossy fibers]), trimer structure/disulfide bridges, signal sequence suggests secretion, [RefSeq, PubMed]; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0099558 maintenance of synapse structure;GO:0090128 regulation of synapse maturation;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CFR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CG16-1", "uniprot_id": "C1RA_MOUSE", "mass": 80073.0, "length": 707, "protein_name": "Complement C1r-A subcomponent", "gene_name": "C1ra", "organism": "Mouse", "refseq_name": "complement C1r-A subcomponent precursor", "refseq_ac": "NP_075632", "gene_names_uniprotkb": "C1ra; C1r", "gene_names_refseq": "C1ra; C1r; mC1rA", "protein_names_uniprotkb": "Complement C1r-A subcomponent; 3.4.21.41; Complement component 1 subcomponent r-A", "protein_names_refseq": "complement C1r-A subcomponent precursor; complement C1r-A subcomponent; complement component 1 subcomponent r-A; complement component 1, r-A subcomponent", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome periodontal type 1 (Disease Ontology:DOID:0080986)", "pathway": " (mmu:50909); (R-MMU-173623); (R-MMU-977606)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11231310;12513694;17159910;17330941;26495903;34428180", "class_list": "", "function": "Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces., [UniProtKB, UniProtKB]; This and C1s genes are duplicated in mice; differential expression generates alternative isomorphs in the liver and in the male reproductive system., [RefSeq, PubMed]; We conclude that IFN-gamma stimulates mC1rA gene expression via IRF-1 in mouse keratinocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q99KI6;Q9ET60", "ec_number_list": "3.4.21.42;3.4.21.41", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0072562 blood microparticle;GO:0005602 complement component C1 complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0045087 innate immune response;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CG16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI33-1", "uniprot_id": "C19L1_MOUSE", "mass": 60193.0, "length": 537, "protein_name": "CWF19-like protein 1", "gene_name": "Cwf19l1", "organism": "Mouse", "refseq_name": "CWF19-like protein 1 isoform 1", "refseq_ac": "NP_001074546", "gene_names_uniprotkb": "Cwf19l1", "gene_names_refseq": "Cwf19l1", "protein_names_uniprotkb": "CWF19-like protein 1", "protein_names_refseq": "CWF19-like 1, cell cycle control; CWF19-like protein 1 isoform 1; CWF19-like protein 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 17 (Disease Ontology:DOID:0080064)", "pathway": " (mmu:72502)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNL3;Q05CB7;Q3UT85;Q8C2J2", "ec_number_list": "", "go_molecular_function": "GO:0061632 RNA lariat debranching enzyme activator activity", "go_cellular_component": "GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CI33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZX9-1", "uniprot_id": "BORG1_MOUSE", "mass": 22997.0, "length": 214, "protein_name": "Cdc42 effector protein 2", "gene_name": "Cdc42ep2", "organism": "Mouse", "refseq_name": "cdc42 effector protein 2", "refseq_ac": "NP_081048", "gene_names_uniprotkb": "Cdc42ep2; Borg1; Cep2", "gene_names_refseq": "1110008C05Rik; Borg1; Cdc42ep2; Cep2; D19Bwg1013e", "protein_names_uniprotkb": "Cdc42 effector protein 2; Binder of Rho GTPases 1", "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 2; binder of Rho GTPases 1; cdc42 effector protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:104252); (R-MMU-5687128); (R-MMU-9013406)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8JZX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2Q7-1", "uniprot_id": "BROX_MOUSE", "mass": 46202.0, "length": 411, "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "Brox", "organism": "Mouse", "refseq_name": "BRO1 domain-containing protein BROX", "refseq_ac": "NP_082137", "gene_names_uniprotkb": "Brox", "gene_names_refseq": "0610010K06Rik; Brox", "protein_names_uniprotkb": "BRO1 domain-containing protein BROX; BRO1 domain- and CAAX motif-containing protein", "protein_names_refseq": "BRO1 domain- and CAAX motif-containing protein; BRO1 domain-containing protein BROX", "tax_id": 10090, "disease": "", "pathway": " (mmu:71678)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22872234;26740625;31219806;34428180;37828378", "class_list": "", "function": "Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWM8;Q9DCT7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007084 mitotic nuclear membrane reassembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K2Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R066-1", "uniprot_id": "C1QT4_MOUSE", "mass": 35058.0, "length": 326, "protein_name": "Complement C1q tumor necrosis factor-related protein 4", "gene_name": "C1qtnf4", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 4 precursor", "refseq_ac": "NP_080437", "gene_names_uniprotkb": "C1qtnf4; Ctrp4", "gene_names_refseq": "0710001E10Rik; 9430004J15Rik; Adin; C1qtnf4; CTRP4", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 4; C1q/TNF-related protein 4", "protein_names_refseq": "C1q/TNF-related protein 4; adiponectin n; complement C1q tumor necrosis factor-related protein 4 precursor; complement C1q tumor necrosis factor-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67445)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16452087;24366864;27086950;33080044;34275474", "class_list": "", "function": "C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-kappaB signaling and microglial activation. Publication Status: Online-Only, [RefSeq, PubMed]; CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock., [RefSeq, PubMed]; CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis., [RefSeq, PubMed]; May be involved in the regulation of the inflammatory network. The role as pro- or anti-inflammatory seems to be context dependent (By similarity). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (Probable)., [UniProtKB, PubMed, UniProtKB]; These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFW1;Q4ZJN5;Q9D0W2;Q9DCB6", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0070105 positive regulation of interleukin-6-mediated signaling pathway;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R087-1", "uniprot_id": "B4GT7_MOUSE", "mass": 37754.0, "length": 327, "protein_name": "Beta-1,4-galactosyltransferase 7", "gene_name": "B4galt7", "organism": "Mouse", "refseq_name": "beta-1,4-galactosyltransferase 7 isoform 2", "refseq_ac": "NP_001298066", "gene_names_uniprotkb": "B4galt7; Xgalt1", "gene_names_refseq": "B4galt7; XGPT; XGalT-1", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 7; 2.4.1.-; 2.4.1.133; Beta-1,4-GalTase 7; Beta4Gal-T7; Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; XGPT; XGalT-1; Xylosylprotein 4-beta-galactosyltransferase; Xylosylprotein beta-1,4-galactosyltransferase; b4Gal-T7", "protein_names_refseq": "UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; b4Gal-T7; beta-1,4-GalTase 7; beta-1,4-galactosyltransferase 7 isoform 2; beta4Gal-T7; proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; xylosylprotein 4-beta-galactosyltransferase; xylosylprotein beta-1,4-galactosyltransferase; xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome spondylodysplastic type 1 (Disease Ontology:DOID:0080738); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": " (mmu:218271); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15282149;21750661", "class_list": "glycogene;glycosyltransferase", "function": "Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts., [UniProtKB, UniProtKB, UniProtKB]; Surface GalT I might negatively regulate mammary epithelial cell survival, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNU3", "ec_number_list": "2.4.1.-;2.4.1.133", "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0030145 manganese ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0046525 xylosylprotein 4-beta-galactosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0048147 negative regulation of fibroblast proliferation;GO:0006487 protein N-linked glycosylation;GO:0006024 glycosaminoglycan biosynthetic process;GO:0006029 proteoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCF1-1", "uniprot_id": "CANT1_MOUSE", "mass": 45653.0, "length": 403, "protein_name": "Soluble calcium-activated nucleotidase 1", "gene_name": "Cant1", "organism": "Mouse", "refseq_name": "soluble calcium-activated nucleotidase 1 isoform a", "refseq_ac": "NP_001020788", "gene_names_uniprotkb": "Cant1", "gene_names_refseq": "5830420C20Rik; Apy1h; Cant1; D11Bwg0554e; Entpd8; SCAN-1; Shapy", "protein_names_uniprotkb": "Soluble calcium-activated nucleotidase 1; 3.6.1.6; Apyrase homolog; SCAN-1", "protein_names_refseq": "Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; apyrase 1, homolog (C. lectularius); apyrase homolog; soluble calcium-activated nucleotidase 1 isoform a; soluble calcium-activated nucleotidase 1", "tax_id": 10090, "disease": "Desbuquois dysplasia (Disease Ontology:DOID:0060462); multiple epiphyseal dysplasia 7 (Disease Ontology:DOID:0070302)", "pathway": " (mmu:76025); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20173027;22451650;26495903;26740625;30439444;32277574;34428180;34502207;35820727;37553672", "class_list": "", "function": "CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage., [RefSeq, PubMed]; Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > IDP >> UTP > CDP = GTP = ITP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis., [UniProtKB, UniProtKB]; Circ_0001715 accelerated lung adenocarcinoma process by the miR-1322/CANT1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Phenotypic Characterization of Immortalized Chondrocytes from a Desbuquois Dysplasia Type 1 Mouse Model: A Tool for Studying Defects in Glycosaminoglycan Biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]; Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation, [RefSeq, PubMed]; The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]., [RefSeq]; To understanding the mechanism of CANT1 mutations in Desbuquois dysplasia type 1, a novel Cant1 knock-in and knock-out murine strains were developed. Both strains present with a skeletal and connective tissue phenotype recapitulating human DBQD1. Cartilage samples and primary chondrocytes demonstrate that CANT1 defects not only affect GAG synthesis, but also GAG elongation, sulfation and PG secretion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AQJ8;Q8C3R8;Q8C4T6;Q9D3F2;Q9D9R1", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.2.1.18;3.6.1.5;3.4.24.34;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.4.21.4;3.6.4.10;3.4.21.-;3.2.1.17;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;3.1.3.48;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.12;2.7.10.2;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.6.1.6;3.6.5.2;3.4.21.37;3.5.3.1;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;3.2.1.166;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;1.8.3.2;1.4.3.22;1.4.3.-;2.7.1.35;3.4.19.1;2.3.1.16;2.3.1.9;2.3.1.155;2.3.3.8;4.1.2.4;2.3.2.5;3.1.21.-;3.2.1.14;5.4.2.11;5.4.2.4;3.6.1.15;3.6.1.42;2.4.1.1;3.5.1.3;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0045134 UDP phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0030166 proteoglycan biosynthetic process;GO:0009191 ribonucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VCF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHB5-1", "uniprot_id": "CAH9_MOUSE", "mass": 47265.0, "length": 437, "protein_name": "Carbonic anhydrase 9", "gene_name": "Ca9; Car9", "organism": "Mouse", "refseq_name": "carbonic anhydrase 9 precursor", "refseq_ac": "NP_647466", "gene_names_uniprotkb": "Ca9; Car9; Car9", "gene_names_refseq": "CAIX; Ca9; Car9; MN/CA9", "protein_names_uniprotkb": "Carbonic anhydrase 9; 4.2.1.1; CA-IX; CAIX; Carbonate dehydratase IX; Carbonic anhydrase IX; Membrane antigen MN homolog", "protein_names_refseq": "CA-IX; carbonate dehydratase IX; carbonic anhydrase 9 precursor; carbonic anhydrase IX; membrane antigen MN homolog", "tax_id": 10090, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); urinary bladder cancer (Disease Ontology:DOID:11054); hepatitis B (Disease Ontology:DOID:2043); transitional cell carcinoma (Disease Ontology:DOID:2671); breast carcinoma (Disease Ontology:DOID:3459); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:230099); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14604546;16245156;21750661;30779550;35773253;37373220", "class_list": "", "function": "Although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach, [RefSeq, PubMed]; Carbonic Anhydrase IX Suppression Shifts Partial Response to Checkpoint Inhibitors into Complete Tumor Eradication: Model-Based Investigation. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions)., [UniProtKB, UniProtKB]; Galectin-1 activates carbonic anhydrase IX and modulates glioma metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1G1;Q8VDE4", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0009410 response to xenobiotic stimulus;GO:0033574 response to testosterone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VHB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIB5-1", "uniprot_id": "BARH2_MOUSE", "mass": 41459.0, "length": 384, "protein_name": "BarH-like 2 homeobox protein", "gene_name": "Barhl2", "organism": "Mouse", "refseq_name": "barH-like 2 homeobox protein", "refseq_ac": "NP_001005477", "gene_names_uniprotkb": "Barhl2; Barh1; Mbh1", "gene_names_refseq": "Barhl2; E130309B19Rik; MBH1", "protein_names_uniprotkb": "BarH-like 2 homeobox protein; Bar-class homeodomain protein MBH1; Homeobox protein B-H1", "protein_names_refseq": "BarH-class homeodomain transcription factor; bar-class homeodomain protein MBH1; barH-like 2 homeobox protein; homeobox protein B-H1", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:104382)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14998930", "class_list": "", "function": "Data suggest that Barhl2 may function to specify the identity of glycinergic amacrine cells from competent progenitors during retinogenesis., [RefSeq, PubMed]; Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66L43", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VIB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VA3-1", "uniprot_id": "CAN8_MOUSE", "mass": 79335.0, "length": 703, "protein_name": "Calpain-8", "gene_name": "Capn8", "organism": "Mouse", "refseq_name": "calpain-8 isoform 2", "refseq_ac": "NP_001139278", "gene_names_uniprotkb": "Capn8; Ncl2", "gene_names_refseq": "Capn8; nCL-2'; nCL-2", "protein_names_uniprotkb": "Calpain-8; 3.4.22.53; New calpain 2; Stomach-specific M-type calpain; nCL-2", "protein_names_refseq": "calpain-8 isoform 2; new calpain 2; stomach-specific M-type calpain; stomach-specific calpain (nCL-2)", "tax_id": 10090, "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:170725); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11523006;16476741;17646163;20686710;21750661", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease (By similarity). Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex., [UniProtKB, PubMed]; Gastrointestinal-tract-specific calpains 8 and 9 formed a complex we termed 'G-calpain,' in which both were essential for gastric mucosal defense Publication Status: Online-Only, [RefSeq, PubMed]; NCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP, [RefSeq, PubMed]; NCL-2/calpain 8 is active without calpain regulatory subunit and oligomerizes through C2-like domains, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059W1;Q91UZ9;Q920R7", "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:1990092 calcium-dependent self proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91VA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WQ9-1", "uniprot_id": "CALL4_MOUSE", "mass": 17671.0, "length": 153, "protein_name": "Calmodulin-like protein 4", "gene_name": "Calml4", "organism": "Mouse", "refseq_name": "calmodulin-like protein 4 isoform a", "refseq_ac": "NP_612177", "gene_names_uniprotkb": "Calml4", "gene_names_refseq": "2010002G05Rik; Calml4", "protein_names_uniprotkb": "Calmodulin-like protein 4; CALM-Rel; Calmodulin-related", "protein_names_refseq": "CALM-Rel; calmodulin-like protein 4 isoform a; calmodulin-like protein 4; calmodulin-related", "tax_id": 10090, "disease": "", "pathway": " (mmu:75600)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11709547;21750661;32209652", "class_list": "", "function": "As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Acts as a light chain for MYO7B and is required for efficient targeting of the IMAC to the tips of border brush microvilli., [UniProtKB, UniProtKB]; The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJ19;Q8C1Q0;Q8R1P1;Q8VD39", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity;GO:0032028 myosin head/neck binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005902 microvillus", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:1904970 brush border assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91WQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZW7-1", "uniprot_id": "C209E_MOUSE", "mass": 24389.0, "length": 208, "protein_name": "CD209 antigen-like protein E", "gene_name": "Cd209e", "organism": "Mouse", "refseq_name": "CD209 antigen-like protein E", "refseq_ac": "NP_570975", "gene_names_uniprotkb": "Cd209e", "gene_names_refseq": "Cd209e; SIGNR4; mSIGNR4", "protein_names_uniprotkb": "CD209 antigen-like protein E; DC-SIGN-related protein 4; DC-SIGNR4", "protein_names_refseq": "C-type lectin; CD209 antigen-like protein E; DC-SIGN-related protein 4; DC-SIGNR4; dendritic cell surface protein; type II transmembrane protein", "tax_id": 10090, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); rheumatic heart disease (Disease Ontology:DOID:0050827); Coronavirus infectious disease (Disease Ontology:DOID:0080599); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); aspergillosis (Disease Ontology:DOID:13564); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:170780)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11581173;19028979", "class_list": "glycogene", "function": "Overexpression of Cd209e is associated with asthma., [RefSeq, PubMed]; Putative pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001618 virus receptor activity;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity;GO:0004895 cell adhesion receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0007159 leukocyte cell-cell adhesion;GO:0046718 symbiont entry into host cell;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91ZW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N23-1", "uniprot_id": "CAH15_MOUSE", "mass": 35482.0, "length": 324, "protein_name": "Carbonic anhydrase 15", "gene_name": "Ca15", "organism": "Mouse", "refseq_name": "carbonic anhydrase 15 precursor", "refseq_ac": "NP_085035", "gene_names_uniprotkb": "Ca15; Car15", "gene_names_refseq": "Ca15; Cals2; Car15", "protein_names_uniprotkb": "Carbonic anhydrase 15; 4.2.1.1; CA-XV; Carbonate dehydratase XV; Carbonic anhydrase XV", "protein_names_refseq": "CA-XV; carbonate dehydratase XV; carbonic anhydrase 15 precursor; carbonic anhydrase XV; carbonic anhydrase-like sequence 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80733)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16083424;18336313;19193158;19206230;20224780;20820888", "class_list": "", "function": "CA XV is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney and may have a role in the regulation of acid-base homeostasis Publication Status: Online-Only, [RefSeq, PubMed]; CA XV is the first member of the alpha-CA gene family that is expressed in several species, but not in humans and chimpanzees., [RefSeq, PubMed]; Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland., [RefSeq, PubMed]; Cloning & purification of CA XV; the enzyme shows a moderate catalytic activity for the physiologic reaction, similarly to the physiologically relevant isoforms CA I, IV, VI, XII, and XIV, and it is susceptible to inhibition by sulfonamides and sulfamates, [RefSeq, PubMed]; Mouse carbonic anhydrase XV, absent in humans, is a moderately active enzyme which may play a physiological role at least in the kidney. [review] Review article, [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99N23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQX3-1", "uniprot_id": "BPIA5_MOUSE", "mass": 29175.0, "length": 270, "protein_name": "BPI fold-containing family A member 5", "gene_name": "Bpifa5", "organism": "Mouse", "refseq_name": "BPI fold-containing family A member 5 precursor", "refseq_ac": "NP_080266", "gene_names_uniprotkb": "Bpifa5; Pluncl; Splunc5", "gene_names_refseq": "2310021H06Rik; 2310074B19Rik; Bpifa5; Pluncl; Splunc5; Tpl", "protein_names_uniprotkb": "BPI fold-containing family A member 5; BPI fold-containing family A member Pluncl; Palate lung and nasal carcinoma-like protein; Short palate lung and nasal clone protein 5; TPL; Tongue plunc-like protein", "protein_names_refseq": "BPI fold-containing family A member 5 precursor; BPI fold-containing family A member Pluncl; palate lung and nasal carcinoma-like protein; short palate lung and nasal clone protein 5; tongue plunc-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67135)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15028288", "class_list": "", "function": "May play a role in innate immunity in the oral cavity., [UniProtKB, PubMed]; Splunc5, splunc1, and lplunc1 are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia [splunc5], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ARM4;Q14BY9;Q8CIW0;Q9D6P0;Q9D794", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0050891 multicellular organismal-level water homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6Y4-1", "uniprot_id": "BORC8_MOUSE", "mass": 13565.0, "length": 120, "protein_name": "BLOC-1-related complex subunit 8", "gene_name": "Borcs8", "organism": "Mouse", "refseq_name": "BLOC-1-related complex subunit 8 isoform 1", "refseq_ac": "NP_001139024", "gene_names_uniprotkb": "Borcs8", "gene_names_refseq": "2310045N01Rik; Borcs8; Mef2bnb", "protein_names_uniprotkb": "BLOC-1-related complex subunit 8", "protein_names_refseq": "BLOC-1-related complex subunit 8 isoform 1; MEF2B neighbor gene protein homolog; protein MEF2BNB", "tax_id": 10090, "disease": "", "pathway": " (mmu:72368)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18299400;21750661;21952136;25428506;30084848;30779550;34428180", "class_list": "", "function": "As part of the BLOC-one-related complex (BORC), it plays a role in the movement and localization of lysosomes at the cell periphery. Associated with the cytosolic face of lysosomes, BORC recruits ARL8B to the lysosomal membrane and couples lysosomes to microtubule plus-end-directed kinesin motors, driving lysosome movement toward the cell periphery., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0007507 heart development;GO:0051036 regulation of endosome size;GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule;GO:0062196 regulation of lysosome size", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D6Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER10-1", "uniprot_id": "BSSP4_MOUSE", "mass": 33432.0, "length": 307, "protein_name": "Brain-specific serine protease 4", "gene_name": "Prss22", "organism": "Mouse", "refseq_name": "brain-specific serine protease 4 precursor", "refseq_ac": "NP_598492", "gene_names_uniprotkb": "Prss22; Bssp4; Prss26", "gene_names_refseq": "4733401N09Rik; BSSP-4; Prss22; SP001LA", "protein_names_uniprotkb": "Brain-specific serine protease 4; 3.4.21.-; BSSP-4; Serine protease 22; Serine protease 26; Tryptase epsilon", "protein_names_refseq": "brain-specific serine protease 4 precursor; brain-specific serine protease 4; protease, serine 22; serine protease 26; tryptase epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:70835)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TML0", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0016504 peptidase activator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0010952 positive regulation of peptidase activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ER10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI08-1", "uniprot_id": "BIN3_MOUSE", "mass": 29651.0, "length": 253, "protein_name": "Bridging integrator 3", "gene_name": "Bin3", "organism": "Mouse", "refseq_name": "bridging integrator 3 isoform 1", "refseq_ac": "NP_067303", "gene_names_uniprotkb": "Bin3", "gene_names_refseq": "1700015F07Rik; Bin3", "protein_names_uniprotkb": "Bridging integrator 3", "protein_names_refseq": "bridging integrator 3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57784)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11274158;21750661;23872330;34428180", "class_list": "", "function": "Bin3 forms a complex with Rac1 and Cdc42, Rho GTPases involved in actin polymerization, which are known to be essential for myotube formation., [RefSeq, PubMed]; Involved in cytokinesis and septation where it has a role in the localization of F-actin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006897 endocytosis;GO:0051301 cell division;GO:0048741 skeletal muscle fiber development;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JI08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI67-1", "uniprot_id": "B3GT5_MOUSE", "mass": 35964.0, "length": 308, "protein_name": "Beta-1,3-galactosyltransferase 5", "gene_name": "B3galt5", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyltransferase 5", "refseq_ac": "NP_001116465", "gene_names_uniprotkb": "B3galt5; B3gt5", "gene_names_refseq": "1190002B21Rik; B3galt5; b3Galt-V", "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 5; 2.4.1.-; Beta-1,3-GalTase 5; Beta-3-Gx-T5; Beta3Gal-T5; Beta3GalT5; SSEA-3 synthase; Stage-specific embryonic antigen 3 synthase; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5; b3Gal-T5", "protein_names_refseq": "SSEA-3 synthase; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5; b3Gal-T5; beta-1,3-GalTase 5; beta-1,3-galactosyltransferase 5; beta-3-Gx-T5; beta3Gal-T5; beta3GalT5; stage-specific embryonic antigen 3 synthase", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:93961); (R-MMU-9037629)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;10837462;16112824", "class_list": "glycogene;glycosyltransferase", "function": "Case study of the endogenous retrovirus long terminal repeat promoter of this enzyme, beta1,3-galactosyltransferase 5, [RefSeq, PubMed]; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.86;2.4.1.-;2.4.1.62", "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 790, "hit_score": 0.6, "record_id": "Q9JI67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI81-1", "uniprot_id": "CAT8_MOUSE", "mass": 37803.0, "length": 333, "protein_name": "Cathepsin 8", "gene_name": "Cts8", "organism": "Mouse", "refseq_name": "cathepsin 8 precursor", "refseq_ac": "NP_062414", "gene_names_uniprotkb": "Cts8; Cts2; Epcs68; Epcs70", "gene_names_refseq": "CTS2; Cts8; Epcs68; Epcs70", "protein_names_uniprotkb": "Cathepsin 8; 3.4.22.-; Cathepsin 2", "protein_names_refseq": "cathepsin 2; cathepsin 8 precursor; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 68", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:56094)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10885754;11829493;18776147", "class_list": "", "function": "Probable protease (By similarity). In placenta, plays a role in promoting giant cell differentiation (PubMed:18776147). Also plays a role in placental spiral artery remodeling by direct degradation of smooth muscle alpha-actin (PubMed:18776147)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6NV96", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding;GO:0042393 histone binding;GO:0008233 peptidase activity;GO:0043394 proteoglycan binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0001974 blood vessel remodeling;GO:0046718 symbiont entry into host cell;GO:0016540 protein autoprocessing;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JI81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK39-1", "uniprot_id": "BTNLA_MOUSE", "mass": 29549.0, "length": 275, "protein_name": "Butyrophilin-like protein 10", "gene_name": "Btnl10", "organism": "Mouse", "refseq_name": "butyrophilin-like protein 10 isoform 2 precursor", "refseq_ac": "NP_619619", "gene_names_uniprotkb": "Btnl10; Butr1", "gene_names_refseq": "BUTR-1; Btnl10; Butr1", "protein_names_uniprotkb": "Butyrophilin-like protein 10", "protein_names_refseq": "butyrophilin related 1; butyrophilin-like protein 10 isoform 2 precursor; butyrophilin-like protein 10; butyrophilin-like protein BUTR-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:192194)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AB75;Q8C0U8", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9JK39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R016-1", "uniprot_id": "BIR1E_MOUSE", "mass": 159839.0, "length": 1403, "protein_name": "Baculoviral IAP repeat-containing protein 1e", "gene_name": "Naip5", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 1e isoform 1", "refseq_ac": "NP_035000", "gene_names_uniprotkb": "Naip5; Birc1e; Naip-rs3", "gene_names_refseq": "Birc1e; Lgn1; Naip-rs3; Naip5", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 1e; Neuronal apoptosis inhibitory protein 5", "protein_names_refseq": "Legionella, susceptiblility 1; baculoviral IAP repeat-containing 1e; baculoviral IAP repeat-containing protein 1e isoform 1; baculoviral IAP repeat-containing protein 1e; neuronal apoptosis inhibitory protein 5; neuronal apoptosis inhibitory protein, related sequence 3", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866)", "pathway": " (mmu:17951)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10486205;10501978;12526741;17114649;18414036;21874021;21918512;27114610;29146805;29182158;34428180;8975718", "class_list": "", "function": "Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella (PubMed:12526741, PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Six distinct NAIP5 domains contact multiple conserved regions of flagellin, prying NAIP5 into an open and active conformation., [RefSeq, PubMed]; These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09121;O09122;P81703;Q8CGT2;Q9R029", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTR5-1", "uniprot_id": "CAD13_MOUSE", "mass": 78186.0, "length": 714, "protein_name": "Cadherin-13", "gene_name": "Cdh13", "organism": "Mouse", "refseq_name": "cadherin-13 preproprotein", "refseq_ac": "NP_062681", "gene_names_uniprotkb": "Cdh13", "gene_names_refseq": "4932416G01Rik; Cdh13; Cdht; Tcad", "protein_names_uniprotkb": "Cadherin-13; H-cadherin; Heart cadherin; T-cadherin; T-cad; Truncated cadherin", "protein_names_refseq": "H-cadherin; T-cadherin; cadherin-13 preproprotein; heart cadherin", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); substance-related disorder (Disease Ontology:DOID:303); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); coronary restenosis (Disease Ontology:DOID:4247); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:12554); (R-MMU-418990)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10737605;12060406;12509455;20190755;27834691;30899004;31219806;33300544;35820727;36288343", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth., [UniProtKB]; Expression of T-cadherin in Basal keratinocytes of skin., [RefSeq, PubMed]; T-cadherin has a role in growth regulation involving p21(CIP1/WAF1) expression and G2 arrest, [RefSeq, PubMed]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 26, "disease_count": 11, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG11", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0071813 lipoprotein particle binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0016477 cell migration;GO:0030100 regulation of endocytosis;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q9WTR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVB5-1", "uniprot_id": "DFB42_MOUSE", "mass": 8287.0, "length": 75, "protein_name": "Beta-defensin 42", "gene_name": "Defb42", "organism": "Mouse", "refseq_name": "beta-defensin 42 precursor", "refseq_ac": "NP_001030082", "gene_names_uniprotkb": "Defb42; Defb44", "gene_names_refseq": "BD-42; Defb42; Defb44; mBD-42", "protein_names_uniprotkb": "Beta-defensin 42; BD-42; Defensin, beta 42; mBD-42", "protein_names_refseq": "beta-defensin 136; beta-defensin 42 precursor; beta-defensin 42; beta-defensin 44", "tax_id": 10090, "disease": "", "pathway": " (mmu:619548); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16023745;16033865;21750661", "class_list": "", "function": "Defb41 and Defb42 are suggested to have a role in the antimicrobial protection of sperm and urogenital tract epithelia. [Defb42], [RefSeq, PubMed]; Has bactericidal activity (By similarity). May play a role in the antimicrobial protection of sperm and urogenital tract epithelia (PubMed:16023745)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZ54", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061760 antifungal innate immune response;GO:0140367 antibacterial innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BVB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70697-1", "uniprot_id": "DCUP_MOUSE", "mass": 40692.0, "length": 367, "protein_name": "Uroporphyrinogen decarboxylase", "gene_name": "Urod", "organism": "Mouse", "refseq_name": "uroporphyrinogen decarboxylase isoform 1", "refseq_ac": "NP_033504", "gene_names_uniprotkb": "Urod", "gene_names_refseq": "UPD; Uro-d; Urod", "protein_names_uniprotkb": "Uroporphyrinogen decarboxylase; 4.1.1.37; UPD; URO-D", "protein_names_refseq": "uroporphyrinogen decarboxylase isoform 1", "tax_id": 10090, "disease": "porphyria (Disease Ontology:DOID:13268); breast cancer (Disease Ontology:DOID:1612); porphyria cutanea tarda (Disease Ontology:DOID:3132); hepatoerythropoietic porphyria (Disease Ontology:DOID:5230)", "pathway": " (mmu:22275); (R-MMU-189451)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12297827;21750661;25428506;30084848;30779550;31219806;34428180;37507081;8661721", "class_list": "", "function": "Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:12297827). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (By similarity). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:8661721)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VW4", "ec_number_list": "4.1.1.37", "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0004853 uroporphyrinogen decarboxylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046502 uroporphyrinogen III metabolic process;GO:0008283 cell population proliferation;GO:0006779 porphyrin-containing compound biosynthetic process;GO:0006783 heme biosynthetic process;GO:0042168 heme metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P70697-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ73-1", "uniprot_id": "DCNL1_MOUSE", "mass": 30097.0, "length": 259, "protein_name": "DCN1-like protein 1", "gene_name": "Dcun1d1", "organism": "Mouse", "refseq_name": "DCN1-like protein 1 isoform 1", "refseq_ac": "NP_001192290", "gene_names_uniprotkb": "Dcun1d1; Dcun1l1; Rp42; SCCRO; Tes3", "gene_names_refseq": "DCNL1; Dcun1d1; Rp42; SCCRO; Tes3; pTes3", "protein_names_uniprotkb": "DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene; Testis-specific protein 3", "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 1; DCN1-like protein 1 isoform 1; DCN1-like protein 1; DCUN1 domain-containing protein 1; defective in cullin neddylation protein 1-like protein 1; squamous cell carcinoma-related oncogene; testis derived transcript 3; testis-specific protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:114893); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10777668;10831844;18826954;20563250;21750661;25411243;26792857;28620047;30653527;36541112", "class_list": "", "function": "DCUN1D1, a new molecule involved in depigmentation via upregulating CXCL10., [RefSeq, PubMed]; Data (including data from studies using cells cultured from knockout mice) suggest that Sccro neddylates Cul3 with Nedd8, promoting Cul3/Klhl21 complex formation and localization of Cul3 during telophase. (Sccro = squamous cell carcinoma-related oncogene; Cul3 = cullin 3; Nedd8 = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 = kelch-like protein 21), [RefSeq, PubMed]; Part of an E3 ubiquitin ligase complex for neddylation (By similarity). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26792857). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (By similarity). Also acts as an oncogene facilitating malignant transformation and carcinogenic progression (PubMed:20563250)., [UniProtKB, UniProtKB, PubMed, PubMed]; SCCRO family members cooperatively regulate neddylation and cell proliferation., [RefSeq, PubMed]; SCCRO promotes glioma formation and malignant progression., [RefSeq, PubMed]; SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation, [RefSeq, PubMed]; Spermatozoa in DCUN1D1-/- mice had multiple abnormalities, including globozoospermia, macrocephaly, and multiple flagella. Publication Status: Online-Only, [RefSeq, PubMed]; The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMX2;Q8CDZ7", "ec_number_list": "", "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0045116 protein neddylation;GO:0031396 regulation of protein ubiquitination;GO:2000436 positive regulation of protein neddylation;GO:2000434 regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QZ73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YP3-1", "uniprot_id": "DEOC_MOUSE", "mass": 34975.0, "length": 318, "protein_name": "Deoxyribose-phosphate aldolase", "gene_name": "Dera", "organism": "Mouse", "refseq_name": "deoxyribose-phosphate aldolase", "refseq_ac": "NP_766321", "gene_names_uniprotkb": "Dera", "gene_names_refseq": "2010002D22Rik; 2500002K03Rik; DEOC; Dera", "protein_names_uniprotkb": "Deoxyribose-phosphate aldolase; 2-deoxy-D-ribose 5-phosphate aldolase; 4.1.2.4; DERA; Deoxyriboaldolase; Phosphodeoxyriboaldolase", "protein_names_refseq": "2-deoxy-D-ribose 5-phosphate aldolase; 2-deoxyribose-5-phosphate aldolase homolog; deoxyriboaldolase; deoxyribose-phosphate aldolase (putative); deoxyribose-phosphate aldolase; phosphodeoxyriboaldolase; putative deoxyribose-phosphate aldolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:232449); (R-MMU-6798695); (R-MMU-71336)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;25605945;34428180;35820727", "class_list": "", "function": "Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD33;Q9CZI8", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0004139 deoxyribose-phosphate aldolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0016052 carbohydrate catabolic process;GO:0046121 deoxyribonucleoside catabolic process;GO:0046386 deoxyribose phosphate catabolic process;GO:0009264 deoxyribonucleotide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91YP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2F3-1", "uniprot_id": "DEPP1_MOUSE", "mass": 22525.0, "length": 205, "protein_name": "Protein DEPP1", "gene_name": "Depp1", "organism": "Mouse", "refseq_name": "protein DEPP1", "refseq_ac": "NP_001160052", "gene_names_uniprotkb": "Depp1; 8430408G22Rik; Depp; Fseg", "gene_names_refseq": "8430408G22Rik; Depp1; Depp; Fseg", "protein_names_uniprotkb": "Protein DEPP1; Fat-specific-expressed gene protein; Protein DEPP", "protein_names_refseq": "decidual protein induced by progesterone; fat-specific expressed; fat-specific-expressed gene protein; protein DEPP1; protein DEPP", "tax_id": 10090, "disease": "", "pathway": " (mmu:213393)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19937567;21750661;24530860;29702025", "class_list": "", "function": "Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS., [UniProtKB, UniProtKB]; DEPP is a novel insulin-regulatory molecule expressed abundantly in insulin-sensitive tissues including white adipose tissue and liver., [RefSeq, PubMed]; Hepatic overexpression of DEPP in mice promotes fatty acid oxidation and ketogenesis and suppresses lipogenesis and gluconeogenesis, which is partly mediated by FGF21 induced by elevated cellular ROS levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BU66", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K2F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4N3-1", "uniprot_id": "DFB12_MOUSE", "mass": 8872.0, "length": 78, "protein_name": "Beta-defensin 12", "gene_name": "Defb12", "organism": "Mouse", "refseq_name": "beta-defensin 12 precursor", "refseq_ac": "NP_690015", "gene_names_uniprotkb": "Defb12", "gene_names_refseq": "9230103N16Rik; BD-12; Defb12", "protein_names_uniprotkb": "Beta-defensin 12; BD-12; Defensin, beta 12; mBD-12", "protein_names_refseq": "beta-defensin 12 precursor; beta-defensin 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:77674)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12193721;14718547;21750661", "class_list": "", "function": "Has antibacterial activity., [UniProtKB, UniProtKB, UniProtKB]; The epididymis-specific expression pattern of beta-defensin isoform mBD-12 has been characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K4N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70KL3-1", "uniprot_id": "DFB39_MOUSE", "mass": 8552.0, "length": 74, "protein_name": "Beta-defensin 39", "gene_name": "Defb39", "organism": "Mouse", "refseq_name": "beta-defensin 39 precursor", "refseq_ac": "NP_898859", "gene_names_uniprotkb": "Defb39", "gene_names_refseq": "BD-39; Defb39", "protein_names_uniprotkb": "Beta-defensin 39; BD-39; Defensin, beta 39; mBD-39", "protein_names_refseq": "beta-defensin 39 precursor; beta-defensin 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:360214)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14718547;21750661", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNV6", "ec_number_list": "", "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q70KL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCV3-1", "uniprot_id": "DGAT2_MOUSE", "mass": 43770.0, "length": 388, "protein_name": "Diacylglycerol O-acyltransferase 2", "gene_name": "Dgat2", "organism": "Mouse", "refseq_name": "diacylglycerol O-acyltransferase 2", "refseq_ac": "NP_080660", "gene_names_uniprotkb": "Dgat2", "gene_names_refseq": "0610010B06Rik; ARAT; DGAT-2; Dgat2", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 2; 2.3.1.20; 2.3.1.76; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2; Retinol O-fatty-acyltransferase", "protein_names_refseq": "acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase 2; diacylglycerol acyltransferase 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:67800); (R-MMU-1482883); (R-MMU-75109)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "11481335;12032764;12413942;14521909;14668353;15258194;15797871;15834126;16001399;16106050;17035227;21680734;21750661;22493088;23066022;34428180;36210013;37644753;38340721", "class_list": "", "function": "DGAT2 expression is increased in diabetic mice., [RefSeq, PubMed]; DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER., [RefSeq, PubMed]; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Role in assembly of de novo synthesized fatty acids into VLDL particles in the liver, [RefSeq, PubMed]; Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes., [RefSeq, PubMed]; The increased rate of hepatic TAG secretion and intracellular accumulation in ob/ob mice is accompanied by parallel increases in the activities of both DGAT I and DGAT II, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-;2.3.1.75;2.3.1.48;1.14.11.68;2.3.1.20;2.3.1.76;2.1.1.364;2.3.1.22;2.7.11.22;2.7.11.23", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0046339 diacylglycerol metabolic process;GO:0097006 regulation of plasma lipoprotein particle levels;GO:0007584 response to nutrient;GO:0046322 negative regulation of fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9DCV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDL0-1", "uniprot_id": "DC1L2_MOUSE", "mass": 54218.0, "length": 492, "protein_name": "Cytoplasmic dynein 1 light intermediate chain 2", "gene_name": "Dync1li2", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 1 light intermediate chain 2", "refseq_ac": "NP_001013398", "gene_names_uniprotkb": "Dync1li2; Dncli2; Dnclic2", "gene_names_refseq": "C920003I06; Dlic2; Dncli2; Dnclic2; Dync1li2; LIC2", "protein_names_uniprotkb": "Cytoplasmic dynein 1 light intermediate chain 2; Dynein light intermediate chain 2, cytosolic", "protein_names_refseq": "cytoplasmic dynein 1 light intermediate chain 2; dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic, light intermediate chain 2; dynein, cytoplasmic, light intermediate polypeptide 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234663); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-68877); (R-MMU-9646399); (R-MMU-9648025)", "pathway_count": 13, "publication_count": 11, "publication_id_list": "11907264;17114649;21183079;21750661;24129315;25428506;25605945;28135057;30084848;30779550;34428180", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that dynein 2 light intermediate chain (D2LIC) is a bona fide subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGJ3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0005770 late endosome;GO:0000776 kinetochore;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0007018 microtubule-based movement;GO:0000226 microtubule cytoskeleton organization;GO:0051642 centrosome localization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6PDL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70385-1", "uniprot_id": "DHB3_MOUSE", "mass": 34330.0, "length": 305, "protein_name": "17-beta-hydroxysteroid dehydrogenase type 3", "gene_name": "Hsd17b3", "organism": "Mouse", "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 3", "refseq_ac": "NP_032317", "gene_names_uniprotkb": "Hsd17b3; Edh17b3", "gene_names_refseq": "Hsd17b3", "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 3; 1.1.1.62; 1.1.1.64; 17-beta-HSD 3; Estradiol 17-beta-dehydrogenase 2; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17-beta-dehydrogenase 3", "protein_names_refseq": "17(beta)HSD type 3; 17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; estradiol 17-beta-dehydrogenase 2; testicular 17-beta-hydroxysteroid dehydrogenase; testosterone 17-beta-dehydrogenase 3", "tax_id": 10090, "disease": "17-beta hydroxysteroid dehydrogenase 3 deficiency (Disease Ontology:DOID:0112248); Alzheimer's disease (Disease Ontology:DOID:10652); disorder of sexual development (Disease Ontology:DOID:1923); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:15487); (R-MMU-193048); (R-MMU-75876)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;30084848;32190925;32557858;38785348;9182854", "class_list": "", "function": "Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:32557858). Favors the reduction of androstenedione to testosterone (PubMed:32557858). Testosterone is the key androgen driving male development and function (PubMed:32190925, PubMed:32557858). Uses NADPH while the two other EDH17B enzymes use NADH (By similarity). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (By similarity). Plays a role in the rate-limiting-step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (PubMed:32190925, PubMed:32557858)., [UniProtKB, UniProtKB, PubMed, PubMed]; HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis but Not in Adults., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3UWF9", "ec_number_list": "1.1.1.330;1.1.1.62;1.1.1.270;1.1.1.210;1.1.1.51;1.1.1.64;1.3.1.3;1.1.1.-;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53", "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity;GO:0047045 testosterone dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0061370 testosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A4P0-1", "uniprot_id": "DHX8_MOUSE", "mass": 142572.0, "length": 1244, "protein_name": "ATP-dependent RNA helicase DHX8", "gene_name": "Dhx8", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DHX8", "refseq_ac": "NP_659080", "gene_names_uniprotkb": "Dhx8", "gene_names_refseq": "Ddx8; Dhx8; mDEAH6; mKIAA4096", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX8; 3.6.4.13; DEAH box protein 8", "protein_names_refseq": "ATP-dependent RNA helicase DHX8; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 8; DEAH (Asp-Glu-Ala-His) box polypeptide 8; DEAH box protein 8; RNA helicase", "tax_id": 10090, "disease": "microcephaly, short stature, and limb abnormalities (Disease Ontology:DOID:0081431); microcephaly-micromelia syndrome (Disease Ontology:DOID:0081432); syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:217207); (R-MMU-72163)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18299400;21750661;30779550;31219806;34428180;39627609", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.2.1.8;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0016604 nuclear body", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2A4P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ADU8-1", "uniprot_id": "DG2L6_MOUSE", "mass": 38362.0, "length": 337, "protein_name": "Diacylglycerol O-acyltransferase 2-like protein 6", "gene_name": "Dgat2l6", "organism": "Mouse", "refseq_name": "diacylglycerol O-acyltransferase 2-like protein 6", "refseq_ac": "NP_001107556", "gene_names_uniprotkb": "Dgat2l6", "gene_names_refseq": "9930021F22Rik; Dgat2l6", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 2-like protein 6; 2.3.1.-", "protein_names_refseq": "diacylglycerol O-acyltransferase 2-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:668257); (R-MMU-1482883)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-;2.3.1.75;2.3.1.20;2.3.1.76;2.3.1.22", "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006640 monoacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2ADU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ADY9-1", "uniprot_id": "DDI2_MOUSE", "mass": 44591.0, "length": 399, "protein_name": "Protein DDI1 homolog 2", "gene_name": "Ddi2", "organism": "Mouse", "refseq_name": "protein DDI1 homolog 2 isoform 1", "refseq_ac": "NP_001017966", "gene_names_uniprotkb": "Ddi2", "gene_names_refseq": "1110056G13Rik; 1700027M01Rik; 9130022E05Rik; Ddi2", "protein_names_uniprotkb": "Protein DDI1 homolog 2; 3.4.23.-", "protein_names_refseq": "protein DDI1 homolog 2 isoform 1; protein DDI1 homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68817)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;31599954", "class_list": "", "function": "Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI1, for cellular survival following replication stress. Together or redundantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0043130 ubiquitin binding;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0016485 protein processing;GO:0031647 regulation of protein stability;GO:0010498 proteasomal protein catabolic process;GO:0097752 regulation of DNA stability;GO:0072711 cellular response to hydroxyurea", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2ADY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TN4-1", "uniprot_id": "DJC16_MOUSE", "mass": 89136.0, "length": 772, "protein_name": "DnaJ homolog subfamily C member 16", "gene_name": "Dnajc16", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 16 precursor", "refseq_ac": "NP_758841", "gene_names_uniprotkb": "Dnajc16; Erdj8; Kiaa0962", "gene_names_refseq": "2900037O03Rik; 4732437J24Rik; D030060M24; Dnajc16; ERdj8; mKIAA0962", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 16; ER-resident protein ERdj8; ERdj8; Endoplasmic reticulum DNA J domain-containing protein 8", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 16; ER-resident protein ERdj8; dnaJ homolog subfamily C member 16 precursor; dnaJ homolog subfamily C member 16; endoplasmic reticulum DNA J domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:214063)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "Plays an important role in regulating the size of autophagosomes during the formation process., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q811G1;Q8BHI2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016243 regulation of autophagosome size", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80TN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHC4-1", "uniprot_id": "DCAKD_MOUSE", "mass": 26476.0, "length": 231, "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "Dcakd", "organism": "Mouse", "refseq_name": "dephospho-CoA kinase domain-containing protein", "refseq_ac": "NP_080827", "gene_names_uniprotkb": "Dcakd", "gene_names_refseq": "3010024O21Rik; 6720485C15Rik; Dcakd", "protein_names_uniprotkb": "Dephospho-CoA kinase domain-containing protein", "protein_names_refseq": "dephospho-CoA kinase domain-containing protein", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation 6 (Disease Ontology:DOID:0110740)", "pathway": " (mmu:68087); (R-MMU-196783)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "18250455;18299400;20173027;21750661;25428506;25428507;25605945;27802388;30084848;30779550;33649389;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004140 dephospho-CoA kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BHC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q30KN4-1", "uniprot_id": "DFB30_MOUSE", "mass": 8734.0, "length": 75, "protein_name": "Beta-defensin 30", "gene_name": "Defb30", "organism": "Mouse", "refseq_name": "beta-defensin 30 isoform 1 precursor", "refseq_ac": "NP_001034655", "gene_names_uniprotkb": "Defb30", "gene_names_refseq": "2410125J01Rik; 4930449O14Rik; BD-30; Defb30; mBD-30", "protein_names_uniprotkb": "Beta-defensin 30; BD-30; Defensin, beta 30; mBD-30", "protein_names_refseq": "beta-defensin 30 isoform 1 precursor; beta-defensin 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:73670); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16033865;21750661", "class_list": "", "function": "Has antibacterial activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140912 membrane destabilizing activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q30KN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1L3-1", "uniprot_id": "DEDD_MOUSE", "mass": 36805.0, "length": 318, "protein_name": "Death effector domain-containing protein", "gene_name": "Dedd", "organism": "Mouse", "refseq_name": "death effector domain-containing protein isoform 1", "refseq_ac": "NP_001122081", "gene_names_uniprotkb": "Dedd", "gene_names_refseq": "CASP8IP1; DEFT; Dedd; Dedpro1; FLDED1; KE05", "protein_names_uniprotkb": "Death effector domain-containing protein; DEDPro1", "protein_names_refseq": "death effector domain-containing protein isoform 1; death effector domain-containing protein; tumor necrosis factor (ligand) superfamily, member 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:21945)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19106089;19260450;20043882;21135503;21750661;34428180;9774341", "class_list": "", "function": "A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DEDD plays an important role in maintenance of the Akt protein level, which in consequence supports the efficient incorporation of glucose into skeletal muscles and adipose tissues., [RefSeq, PubMed]; In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was accompanied by disintegration of implantation site structure, leading to embryonic death before placentation., [RefSeq, PubMed]; It regulates cell cycle and cell sizing. (review) Review article, [RefSeq, PubMed]; The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQH8;Q9R227", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0042981 regulation of apoptotic process;GO:0042177 negative regulation of protein catabolic process;GO:0046697 decidualization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z1L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCA0-1", "uniprot_id": "DCNL4_MOUSE", "mass": 33939.0, "length": 292, "protein_name": "DCN1-like protein 4", "gene_name": "Dcun1d4", "organism": "Mouse", "refseq_name": "DCN1-like protein 4 isoform C", "refseq_ac": "NP_001177662", "gene_names_uniprotkb": "Dcun1d4; SCCRO4", "gene_names_refseq": "DCNL4; Dcun1d4", "protein_names_uniprotkb": "DCN1-like protein 4; DCNL4; DCUN1 domain-containing protein 4; Defective in cullin neddylation protein 1-like protein 4; Squamous cell carcinoma-related oncogene 4", "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 4; DCN1-like protein 4 isoform C; DCN1-like protein 4; DCUN1 domain-containing protein 4; defective in cullin neddylation protein 1-like protein 4; squamous cell carcinoma-related oncogene 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:100737); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;26792857", "class_list": "", "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDW5", "ec_number_list": "", "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CCA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9Z5-1", "uniprot_id": "DDA1_MOUSE", "mass": 11753.0, "length": 102, "protein_name": "DET1- and DDB1-associated protein 1", "gene_name": "Dda1", "organism": "Mouse", "refseq_name": "DET1- and DDB1-associated protein 1 isoform 2", "refseq_ac": "NP_001281187", "gene_names_uniprotkb": "Dda1", "gene_names_refseq": "1500034J01Rik; 1700095J19Rik; Dda1", "protein_names_uniprotkb": "DET1- and DDB1-associated protein 1", "protein_names_refseq": "DET1- and DDB1-associated protein 1 isoform 2; DET1- and DDB1-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66498); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;22645316;28211159", "class_list": "", "function": "Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDQ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D9Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z6H8-1", "uniprot_id": "DCAM2_MOUSE", "mass": 38295.0, "length": 334, "protein_name": "S-adenosylmethionine decarboxylase proenzyme 2", "gene_name": "Amd2", "organism": "Mouse", "refseq_name": "S-adenosylmethionine decarboxylase proenzyme 2", "refseq_ac": "NP_031470", "gene_names_uniprotkb": "Amd2; Amd-2", "gene_names_refseq": "AdoMetDC; Amd1; Amd2; Amd3", "protein_names_uniprotkb": "S-adenosylmethionine decarboxylase proenzyme 2; 4.1.1.50; AdoMetDC 2; SAMDC 2", "protein_names_refseq": "AdoMetDC 1; S-adenosylmethionine decarboxylase proenzyme 1; S-adenosylmethionine decarboxylase proenzyme 2; SAMDC 1; SAMDC 2; adenosylmethionine decarboxylase 2; adoMetDC 2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:100041585)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7890685;9620866", "class_list": "", "function": "Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P82184;Q58E47", "ec_number_list": "4.1.1.50", "go_molecular_function": "GO:0019810 putrescine binding;GO:0042802 identical protein binding;GO:0004014 adenosylmethionine decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process;GO:0046500 S-adenosylmethionine metabolic process;GO:0006595 polyamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z6H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH88-1", "uniprot_id": "DEP1B_MOUSE", "mass": 61908.0, "length": 529, "protein_name": "DEP domain-containing protein 1B", "gene_name": "Depdc1b", "organism": "Mouse", "refseq_name": "DEP domain-containing protein 1B isoform 1", "refseq_ac": "NP_848798", "gene_names_uniprotkb": "Depdc1b", "gene_names_refseq": "9830132O03; Depdc1b; XTP1", "protein_names_uniprotkb": "DEP domain-containing protein 1B", "protein_names_refseq": "DEP domain-containing protein 1B isoform 1; DEP domain-containing protein 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:218581); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424); (R-MMU-9035034); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 17, "publication_count": 5, "publication_id_list": "21750661;31219806;31825138;34428180;36913076", "class_list": "", "function": "Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis., [RefSeq, PubMed]; DEPDC1B plays a central role in myoblasts by driving proliferation and preventing precocious myogenic differentiation during skeletal myogenesis in both mouse and human., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810T1;Q8BZ67", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0016477 cell migration;GO:0035556 intracellular signal transduction;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BH88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQT7-1", "uniprot_id": "DESI1_MOUSE", "mass": 18385.0, "length": 168, "protein_name": "Desumoylating isopeptidase 1", "gene_name": "Desi1", "organism": "Mouse", "refseq_name": "desumoylating isopeptidase 1 isoform 1", "refseq_ac": "NP_598856", "gene_names_uniprotkb": "Desi1; D15Wsu75e; Fam152b; Pppde2", "gene_names_refseq": "D15Wsu75e; DeSI-1; Desi1; Fam152b; Pppde2", "protein_names_uniprotkb": "Desumoylating isopeptidase 1; 3.1.2.22; 3.4.-.-; DeSI-1; PPPDE peptidase domain-containing protein 2; Palmitoyl protein thioesterase DESI1; S-depalmitoylase DESI1", "protein_names_refseq": "PPPDE peptidase domain containing 2; PPPDE peptidase domain-containing protein 2; S-depalmitoylase DESI1; desumoylating isopeptidase 1 isoform 1; family with sequence similarity 152, member B; palmitoyl protein thioesterase DESI1", "tax_id": 10090, "disease": "", "pathway": " (mmu:28075)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22370726;22498933", "class_list": "", "function": "A new deSUMOylase named DeSI-1 (DeSumoylating Isopeptidase 1), was identified., [RefSeq, PubMed]; Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins (PubMed:22370726, PubMed:22498933). Has isopeptidase but not SUMO-processing activity (PubMed:22370726, PubMed:22498933). Desumoylates ZBTB46 (PubMed:22370726). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2M9", "ec_number_list": "3.1.2.22;3.1.2.2;3.1.2.-;2.3.1.-;3.1.1.93;3.4.-.-;3.4.19.12", "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0061676 importin-alpha family protein binding;GO:0042802 identical protein binding;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006611 protein export from nucleus;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0016926 protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2D3-1", "uniprot_id": "GSDME_MOUSE", "mass": 56631.0, "length": 512, "protein_name": "Gasdermin-E", "gene_name": "Gsdme", "organism": "Mouse", "refseq_name": "gasdermin-E precursor", "refseq_ac": "NP_061239", "gene_names_uniprotkb": "Gsdme; Dfna5h; Dfna5", "gene_names_refseq": "2310037D07Rik; 4932441K13Rik; Dfna5h; Dfna5; EG14210; Fin15; Gsdme", "protein_names_uniprotkb": "Gasdermin-E; Non-syndromic hearing impairment protein 5 homolog", "protein_names_refseq": "deafness associated tumor suppressor; deafness, autosomal dominant 5 homolog; gasdermin-E precursor; non-syndromic hearing impairment protein 5 homolog", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 5 (Disease Ontology:DOID:0110575); sensorineural hearing loss (Disease Ontology:DOID:10003); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:54722); (R-MMU-111457); (R-MMU-111458); (R-MMU-111461); (R-MMU-5620971); (R-MMU-5686938)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "21750661;28045099;28459430;31361958;32188940;33852854;9771715", "class_list": "", "function": "Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively (PubMed:32188940). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis (PubMed:33852854). Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (By similarity). Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed:32188940). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (By similarity). Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity (PubMed:32188940). Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression (By similarity). May play a role in the p53/TP53-regulated cellular response to DNA damage (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0022829 wide pore channel activity;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0007605 sensory perception of sound;GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;GO:0071356 cellular response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNV0-1", "uniprot_id": "DEK_MOUSE", "mass": 43159.0, "length": 380, "protein_name": "Protein DEK", "gene_name": "Dek", "organism": "Mouse", "refseq_name": "protein DEK", "refseq_ac": "NP_080176", "gene_names_uniprotkb": "Dek", "gene_names_refseq": "1810019E15Rik; D13H6S231E; Dek", "protein_names_uniprotkb": "Protein DEK", "protein_names_refseq": "DEK oncogene (DNA binding); DEK proto-oncogene (DNA binding); protein DEK", "tax_id": 10090, "disease": "", "pathway": " (mmu:110052); (R-MMU-5250924); (R-MMU-8864260)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "17242355;17524367;18630941;21183079;21750661;25153642;26495903;28528544;30084848;33755722;34428180;35820727;36115279;38274803", "class_list": "", "function": "DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in chromatin organization., [UniProtKB, PubMed]; MiR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK., [RefSeq, PubMed]; Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VC5;Q8BZV6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0043292 contractile muscle fiber;GO:0110016 B-WICH complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TNV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09005-1", "uniprot_id": "DEGS1_MOUSE", "mass": 38241.0, "length": 323, "protein_name": "Sphingolipid delta(4)-desaturase DES1", "gene_name": "Degs1", "organism": "Mouse", "refseq_name": "sphingolipid delta(4)-desaturase DES1 isoform 1", "refseq_ac": "NP_031879", "gene_names_uniprotkb": "Degs1; Degs; Des1; Mdes", "gene_names_refseq": "Degs1; Degs; Des1; Mdes", "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase DES1; 1.14.19.17; 5.2.1.-; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Retinol isomerase", "protein_names_refseq": "degenerative spermatocyte homolog 1; dihydroceramide desaturase-1; dihydroceramide desaturase; retinol isomerase; sphingolipid delta(4)-desaturase DES1 isoform 1; sphingolipid delta(4)-desaturase DES1", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 18 (Disease Ontology:DOID:0070399); neurodegenerative disease (Disease Ontology:DOID:1289); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13244); (R-MMU-1660661); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11937514;15371559;21750661;23143414;29963848;30645148;31273070;34203471;34428180;9227906", "class_list": "glycogene", "function": "Biochemical assays, cellular lipid feeding experiments, and pharmacological blockade of ceramide synthase (dihydroceramide desaturase) together show that this enzyme indeed controls the flux of ceramides on maturing phagosomes., [RefSeq, PubMed]; Des1 expression in Muller cells is not required for cone visual pigment regeneration in the mouse., [RefSeq, PubMed]; GT11 is the first specific inhibitor of dihydroceramide desaturase described so far, [RefSeq, PubMed]; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols (By similarity)., [UniProtKB, PubMed, UniProtKB]; These studies suggest that inhibition of DES1 may provide a means of treating hepatic steatosis and metabolic disorders, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4H3", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;3.6.5.2;1.1.1.-;3.4.24.-;2.3.1.78;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.3.1.51;1.14.18.5;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0042284 sphingolipid delta-4 desaturase activity;GO:0050251 retinol isomerase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0043065 positive regulation of apoptotic process;GO:0046513 ceramide biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O09005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TXU5-1", "uniprot_id": "DHYS_MOUSE", "mass": 40642.0, "length": 369, "protein_name": "Deoxyhypusine synthase", "gene_name": "Dhps", "organism": "Mouse", "refseq_name": "deoxyhypusine synthase", "refseq_ac": "NP_001034603", "gene_names_uniprotkb": "Dhps", "gene_names_refseq": "Dhps; Dhs", "protein_names_uniprotkb": "Deoxyhypusine synthase; 2.5.1.46; DHS", "protein_names_refseq": "deoxyhypusine synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:330817); (R-MMU-204626)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20956533;21389784;21750661;34688659;37333770", "class_list": "", "function": "Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DHS is required for the ongoing production of proteins, particularly CHOP, in response to ER stress in the beta cell., [RefSeq, PubMed]; Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling., [RefSeq, PubMed]; Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QM48", "ec_number_list": "2.5.1.46", "go_molecular_function": "GO:0034038 deoxyhypusine synthase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008216 spermidine metabolic process;GO:0046203 spermidine catabolic process;GO:0042593 glucose homeostasis;GO:0042102 positive regulation of T cell proliferation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TXU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LD8-1", "uniprot_id": "DDAH2_MOUSE", "mass": 29646.0, "length": 285, "protein_name": "Putative hydrolase DDAH2", "gene_name": "Ddah2", "organism": "Mouse", "refseq_name": "putative hydrolase DDAH2 isoform 1", "refseq_ac": "NP_001177378", "gene_names_uniprotkb": "Ddah2", "gene_names_refseq": "1110003M04Rik; DDAH-2; DDAHII; Ddah2; Ddah; G6a; NG30", "protein_names_uniprotkb": "Putative hydrolase DDAH2; 3.-.-.-; DDAH-2; DDAHII; Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Inactive dimethylarginine dimethylaminohydrolase 2", "protein_names_refseq": "Clone 7u; N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; dimethylargininase-2; inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; inactive dimethylarginine dimethylaminohydrolase 2; putative hydrolase DDAH2 isoform 1; putative hydrolase DDAH2", "tax_id": 10090, "disease": "", "pathway": " (mmu:51793)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;16574895;17601800;21493890;21750661;22645316;23430976;27838434;28135057;32782141;32848054;33850055;36852467;37296100;37507081;40021952;40885482", "class_list": "", "function": "A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase. Publication Status: Online-Only, [RefSeq, PubMed]; DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission. Publication Status: Online-Only, [RefSeq, PubMed]; DDAH2/ADMA pathway can be a novel therapeutic target for vasculopathy in the ADMA or angiotensin II-induced pathophysiological conditions, [RefSeq, PubMed]; Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (PubMed:16574895). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (PubMed:23430976). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; We conclude that pp60(Src) can directly inhibit DDAH II and this is involved in the increased ADMA levels that enhance eNOS uncoupling during the development of acute lung injury (ALI)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016403 dimethylargininase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q99LD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZB9-1", "uniprot_id": "DCTN5_MOUSE", "mass": 20141.0, "length": 182, "protein_name": "Dynactin subunit 5", "gene_name": "Dctn5", "organism": "Mouse", "refseq_name": "dynactin subunit 5", "refseq_ac": "NP_067621", "gene_names_uniprotkb": "Dctn5", "gene_names_refseq": "4930427E12Rik; Dctn5; b2b315Clo", "protein_names_uniprotkb": "Dynactin subunit 5; Dynactin subunit p25", "protein_names_refseq": "dynactin 4; dynactin subunit 5; dynactin subunit p25; p25 dynactin subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:59288); (R-MMU-2132295); (R-MMU-3371497); (R-MMU-6807878); (R-MMU-6811436)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10525537;21750661;33300544;34197691;34428180", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9A4;Q8BPE5;Q91XC6;Q99J17", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0031965 nuclear membrane;GO:0005869 dynactin complex;GO:0000776 kinetochore", "go_biological_process": "GO:0003281 ventricular septum development;GO:0035904 aorta development;GO:0060976 coronary vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54786-1", "uniprot_id": "DFFA_MOUSE", "mass": 36572.0, "length": 331, "protein_name": "DNA fragmentation factor subunit alpha", "gene_name": "Dffa", "organism": "Mouse", "refseq_name": "DNA fragmentation factor subunit alpha isoform a", "refseq_ac": "NP_001020467", "gene_names_uniprotkb": "Dffa; Icad", "gene_names_refseq": "A330085O09Rik; DFF35; Dff45; Dffa; ICAD-L; ICAD-S; ICAD", "protein_names_uniprotkb": "DNA fragmentation factor subunit alpha; DFF-45; DNA fragmentation factor 45 kDa subunit; ICAD; Inhibitor of CAD", "protein_names_refseq": "DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha isoform a; inhibitor of CAD", "tax_id": 10090, "disease": "", "pathway": " (mmu:13347); (R-MMU-140342)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16432220;29187734;34428180;9422506;9422513", "class_list": "", "function": "Apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression, [RefSeq, PubMed]; Inhibitor of the caspase-activated DNase (DFF40)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KFX0;O54787;Q8BQC7", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0044183 protein folding chaperone;GO:0060703 deoxyribonuclease inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0006457 protein folding;GO:0070242 thymocyte apoptotic process;GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O54786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70503-1", "uniprot_id": "DHB12_MOUSE", "mass": 34742.0, "length": 312, "protein_name": "Very-long-chain 3-oxoacyl-CoA reductase", "gene_name": "Hsd17b12", "organism": "Mouse", "refseq_name": "very-long-chain 3-oxoacyl-CoA reductase", "refseq_ac": "NP_062631", "gene_names_uniprotkb": "Hsd17b12; Kik1", "gene_names_refseq": "2610510O05Rik; Hsd17b12; KIK-I; Kik1", "protein_names_uniprotkb": "Very-long-chain 3-oxoacyl-CoA reductase; 1.1.1.330; 1.1.1.62; 17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; Estradiol 17-beta-dehydrogenase 12; KAR; KIK-I", "protein_names_refseq": "17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; KAR; estradiol 17-beta-dehydrogenase 12; keratoadhesin; keratonectin; steroid dehydrogenase; very-long-chain 3-oxoacyl-CoA reductase", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56348); (R-MMU-193048); (R-MMU-75876)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "12482854;22645316;22872234;27490311;28135057;28528544;30084848;31219806;32691632;34428180;35820727;36210013;37453647;37507081", "class_list": "", "function": "Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation., [UniProtKB, UniProtKB]; Hydroxysteroid (17beta) dehydrogenase 12 is essential for metabolic homeostasis in adult mice., [RefSeq, PubMed]; Important role in female fertility through its role in arachidonic acid metabolism, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TID1;Q3U7V9;Q542N3;Q8CI39", "ec_number_list": "1.1.1.300;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;1.1.1.330;1.1.1.270;1.1.1.210;1.1.1.n12;1.1.1.51;1.1.1.64;1.1.1.-;1.1.1.105;1.1.1.209", "go_molecular_function": "GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0016491 oxidoreductase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane;GO:0009923 fatty acid elongase complex", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion;GO:0006702 androgen biosynthetic process;GO:0006703 estrogen biosynthetic process;GO:0019367 fatty acid elongation, saturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O70503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88455-1", "uniprot_id": "DHCR7_MOUSE", "mass": 53919.0, "length": 471, "protein_name": "7-dehydrocholesterol reductase", "gene_name": "Dhcr7", "organism": "Mouse", "refseq_name": "7-dehydrocholesterol reductase isoform 1", "refseq_ac": "NP_031882", "gene_names_uniprotkb": "Dhcr7", "gene_names_refseq": "Dhcr7", "protein_names_uniprotkb": "7-dehydrocholesterol reductase; 1.3.1.21; 3.3.2.11; 7-DHC reductase; Cholesterol-5,6-epoxide hydrolase subunit DHCR7; Sterol Delta(7)-reductase", "protein_names_refseq": "7-DHC reductase; 7-dehydrocholesterol reductase isoform 1; cholesterol-5,6-epoxide hydrolase subunit DHCR7; sterol Delta(7)-reductase", "tax_id": 10090, "disease": "Behcet's disease (Disease Ontology:DOID:13241); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692)", "pathway": " (mmu:13360); (R-MMU-6807047); (R-MMU-9969901)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11230174;21750661;21952136;34428180;38297130;9653161", "class_list": "", "function": "Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis., [UniProtKB, UniProtKB, UniProtKB]; Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between cholestenol Delta-isomerase/EBP and DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (PubMed:11230174, PubMed:38297130). Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (PubMed:11230174). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (PubMed:38297130)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.21;3.3.2.11;1.3.1.70;5.3.3.5", "go_molecular_function": "GO:0047598 7-dehydrocholesterol reductase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0050661 NADP binding;GO:0033963 cholesterol-5,6-oxide hydrolase activity;GO:0050613 Delta14-sterol reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0016126 sterol biosynthetic process;GO:0030324 lung development;GO:0045540 regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88455-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88533-1", "uniprot_id": "DDC_MOUSE", "mass": 53874.0, "length": 480, "protein_name": "Aromatic-L-amino-acid decarboxylase", "gene_name": "Ddc", "organism": "Mouse", "refseq_name": "aromatic-L-amino-acid decarboxylase", "refseq_ac": "NP_001177377", "gene_names_uniprotkb": "Ddc", "gene_names_refseq": "Aadc; Ddc", "protein_names_uniprotkb": "Aromatic-L-amino-acid decarboxylase; 4.1.1.28; AADC; DDC; DOPA decarboxylase", "protein_names_refseq": "aromatic-L-amino-acid decarboxylase", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); aromatic L-amino acid decarboxylase deficiency (Disease Ontology:DOID:0090123); portal hypertension (Disease Ontology:DOID:10762); nephrotic syndrome (Disease Ontology:DOID:1184); Parkinson's disease (Disease Ontology:DOID:14330); hyperinsulinism (Disease Ontology:DOID:2018); bipolar disorder (Disease Ontology:DOID:3312); inherited metabolic disorder (Disease Ontology:DOID:655); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:13195); (R-MMU-209905); (R-MMU-209931)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;37601086", "class_list": "", "function": "Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Effects of Venlafaxine on the Size of Brain and Expression of SHANK3, TUBB5 and DDC Genes in BALB/c Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.28", "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030170 pyridoxal phosphate binding;GO:0016597 amino acid binding;GO:0004058 aromatic-L-amino-acid decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0001822 kidney development;GO:0009636 response to toxic substance;GO:0042416 dopamine biosynthetic process;GO:0006584 catecholamine metabolic process;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88673-1", "uniprot_id": "DGKA_MOUSE", "mass": 82762.0, "length": 730, "protein_name": "Diacylglycerol kinase alpha", "gene_name": "Dgka", "organism": "Mouse", "refseq_name": "diacylglycerol kinase alpha isoform 1", "refseq_ac": "NP_058091", "gene_names_uniprotkb": "Dgka; Dagk1", "gene_names_refseq": "80kDa; Dagk1; Dgka", "protein_names_uniprotkb": "Diacylglycerol kinase alpha; 2.7.1.107; 2.7.1.93; 80 kDa diacylglycerol kinase; DAG kinase alpha; DGK-alpha; Diglyceride kinase alpha", "protein_names_refseq": "80 kDa diacylglycerol kinase; DAG kinase alpha; DGK-alpha; diacylglycerol kinase alpha Flt2-Pr2; diacylglycerol kinase alpha isoform 1; diglyceride kinase alpha", "tax_id": 10090, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:13139); (R-MMU-114508)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "32010133;34428180;34804012;36920384;38105414", "class_list": "", "function": "Ablation of DGKalpha facilitates alpha-smooth muscle actin expression via the Smad and PKCdelta signaling pathways during the acute phase of CCl4 -induced hepatic injury., [RefSeq, PubMed]; DGK alpha and zeta Activities Control TH1 and TH17 Cell Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol., [UniProtKB, UniProtKB]; Loss of Diacylglycerol Kinase alpha Enhances Macrophage Responsiveness. Publication Status: Online-Only, [RefSeq, PubMed]; Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase alpha-Deficient Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922X2", "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88673-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16381-1", "uniprot_id": "DDX3L_MOUSE", "mass": 73141.0, "length": 660, "protein_name": "Putative ATP-dependent RNA helicase Pl10", "gene_name": "D1Pas1", "organism": "Mouse", "refseq_name": "putative ATP-dependent RNA helicase Pl10", "refseq_ac": "NP_149068", "gene_names_uniprotkb": "D1Pas1; Pl10", "gene_names_refseq": "D1Pas1; DDX3XL; Pl10", "protein_names_uniprotkb": "Putative ATP-dependent RNA helicase Pl10; 3.6.4.13", "protein_names_refseq": "putative ATP-dependent RNA helicase Pl10", "tax_id": 10090, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); childhood medulloblastoma (Disease Ontology:DOID:3869)", "pathway": " (mmu:110957)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16728723;22645316;24788674;25605945;2720782;33300544;35820727;37507081", "class_list": "", "function": "Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process., [UniProtKB]; Unlike DBY in humans, the role of Dby in spermatogenesis is less obvious in the mouse and its biologic activity may be replaced by that of Ddx3 and D1Pas1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0014069 postsynaptic density;GO:0043186 P granule", "go_biological_process": "GO:0007283 spermatogenesis;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P16381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17533-1", "uniprot_id": "DFA29_MOUSE", "mass": 12941.0, "length": 116, "protein_name": "Alpha-defensin 29", "gene_name": "Defa29", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Defa29; Defa-rs1; Defcr-rs1", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-defensin 29; Alpha-defensin-related sequence 1; CRS1C; Cryptdin-related protein 1C; Defensin-related cryptdin-related sequence 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2351676", "class_list": "", "function": "Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats (PubMed:2351676). Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins (PubMed:2351676)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QVW7", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17534-1", "uniprot_id": "DFAR2_MOUSE", "mass": 9980.0, "length": 91, "protein_name": "Alpha-defensin-related sequence 2", "gene_name": "Defa-rs2", "organism": "Mouse", "refseq_name": "alpha-defensin-related sequence 2 precursor", "refseq_ac": "NP_031873", "gene_names_uniprotkb": "Defa-rs2; Defcr-rs2", "gene_names_refseq": "CRS4C-1; CRS4C1d; CRS4C1e; CRS4C1f; CRS4C1g; CRS4C1h; CRS4C1i; CRS4C1j; CRS4C; Defa-rs2; Defcr-rs2; Defcr-rs3", "protein_names_uniprotkb": "Alpha-defensin-related sequence 2; CRS4C1; Cryptdin-related protein 4C-1; Defensin-related cryptdin-related sequence 2", "protein_names_refseq": "alpha-defensin-related sequence 2 precursor; alpha-defensin-related sequence 2; cryptdin related sequence peptide; cryptdin-related protein 4C-1; defensin related cryptdin, related sequence 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13222)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20056603;2351676;7896294", "class_list": "", "function": "Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities., [UniProtKB]; Data show that in ileitis-prone mice, Paneth cell levels of CRS4C mRNAs and peptides are induced more than a 1000-fold relative to non-prone strains as early as 4 weeks of age., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64111", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0042582 azurophil granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17534-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23738-1", "uniprot_id": "DCHS_MOUSE", "mass": 74045.0, "length": 662, "protein_name": "Histidine decarboxylase", "gene_name": "Hdc", "organism": "Mouse", "refseq_name": "histidine decarboxylase", "refseq_ac": "NP_032256", "gene_names_uniprotkb": "Hdc", "gene_names_refseq": "Hdc-a; Hdc-c; Hdc-e; Hdc-s; Hdc", "protein_names_uniprotkb": "Histidine decarboxylase; 4.1.1.22; HDC", "protein_names_refseq": "L-histidine decarboxylase; histidine decarboxylase", "tax_id": 10090, "disease": "Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:15186); (R-MMU-70921)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "2125007;30084848;35820727;8250869;8268224", "class_list": "", "function": "Catalyzes the biosynthesis of histamine from histidine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWU3", "ec_number_list": "4.1.1.22", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004398 histidine decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006548 L-histidine catabolic process;GO:0001694 histamine biosynthetic process;GO:0006547 L-histidine metabolic process;GO:0042423 catecholamine biosynthetic process;GO:0001692 histamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23738-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28309-1", "uniprot_id": "DEFA2_MOUSE", "mass": 10560.0, "length": 93, "protein_name": "Alpha-defensin 2", "gene_name": "Defa2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Defa2; Defcr2", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-defensin 2; Cryptdin-1; Defensin-related cryptdin-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1500163;1500431;8043949;8188287", "class_list": "", "function": "Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse-virulent S.typhimurium 14028S. Probably contributes to the antimicrobial barrier function of the small bowel mucosa., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P82293;Q60616;Q62537", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28310-1", "uniprot_id": "DEFA3_MOUSE", "mass": 10528.0, "length": 93, "protein_name": "Alpha-defensin 3", "gene_name": "Defa3", "organism": "Mouse", "refseq_name": "alpha-defensin 17 preproprotein", "refseq_ac": "NP_001161262", "gene_names_uniprotkb": "Defa3; Defcr3", "gene_names_refseq": "Cryp17; Defa17; Defa3; Defcr17; Defcr3", "protein_names_uniprotkb": "Alpha-defensin 3; Defensin-related cryptdin-3", "protein_names_refseq": "Alpha-defensin 3; alpha-defensin 17 preproprotein; alpha-defensin 17; crypt defensin 17; cryptdin 17; defensin-related cryptdin-17", "tax_id": 10090, "disease": "", "pathway": " (mmu:13237); (mmu:23855); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "1500431;8188287", "class_list": "", "function": "Probably contributes to the antimicrobial barrier function of the small bowel mucosa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499K7", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P28310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28311-1", "uniprot_id": "DEFA4_MOUSE", "mass": 10272.0, "length": 92, "protein_name": "Defensin alpha 4", "gene_name": "Defa4", "organism": "Mouse", "refseq_name": "defensin alpha 4 precursor", "refseq_ac": "NP_034169", "gene_names_uniprotkb": "Defa4; Defcr4", "gene_names_refseq": "Crp4; Defa28; Defa4; Defcr4", "protein_names_uniprotkb": "Defensin alpha 4; Defensin-related cryptdin-4", "protein_names_refseq": "alpha-defensin 4; alpha-defensin, 28; defensin alpha 4 precursor; defensin related cryptdin 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:13238)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10569786;1500431;15595831;35456043;7927786;8188287", "class_list": "", "function": "Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; Host-defense peptide that has antimicrobial activity (PubMed:7927786). Exhibits activity against Gram-negative E.coli (in vitro) (PubMed:7927786). Probably contributes to the antimicrobial barrier function of the small bowel mucosa (PubMed:7927786)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KPC1;Q9QZL4", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030133 transport vesicle;GO:0042582 azurophil granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43346-1", "uniprot_id": "DCK_MOUSE", "mass": 30367.0, "length": 260, "protein_name": "Deoxycytidine kinase", "gene_name": "Dck", "organism": "Mouse", "refseq_name": "deoxycytidine kinase", "refseq_ac": "NP_031858", "gene_names_uniprotkb": "Dck", "gene_names_refseq": "Dck", "protein_names_uniprotkb": "Deoxycytidine kinase; 2.7.1.113; 2.7.1.74; 2.7.1.76; Deoxyadenosine kinase; Deoxyguanosine kinase; dCK", "protein_names_refseq": "deoxyadenosine kinase; deoxycytidine kinase; deoxyguanosine kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:13178); (R-MMU-73614); (R-MMU-74217)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11150511;17525332;21183079;23392349;25101980;7929097", "class_list": "", "function": "Activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement and suggests a novel therapeutic target for the treatment of COPD, [RefSeq, PubMed]; Mutation of a single serine 74 residue has profound effects on murine T and B lymphocyte development, suggesting that post-translational regulation of dCK has a role in maintaining genomic stability during hematopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.113;2.7.1.76;2.7.1.74", "go_molecular_function": "GO:0004138 deoxyguanosine kinase activity;GO:0032548 pyrimidine deoxyribonucleoside binding;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046092 deoxycytidine metabolic process;GO:0032261 purine nucleotide salvage;GO:0006220 pyrimidine nucleotide metabolic process;GO:1901293 nucleoside phosphate biosynthetic process;GO:0106384 dGMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43346-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50704-1", "uniprot_id": "DEFA6_MOUSE", "mass": 10426.0, "length": 93, "protein_name": "Alpha-defensin 6/12", "gene_name": "Defa12; Defa6", "organism": "Mouse", "refseq_name": "alpha-defensin 6/12 precursor", "refseq_ac": "NP_031878", "gene_names_uniprotkb": "Defa12; Defa6; Defcr12; Defcr6", "gene_names_refseq": "Defa6; Defcr6", "protein_names_uniprotkb": "Alpha-defensin 6/12; Cryptdin-2; Defensin-related cryptdin-6/12", "protein_names_refseq": "alpha-defensin 6/12 precursor; alpha-defensin 6/12; alpha-defensin, 6; cryptdin-2; defensin related cryptdin 6; defensin-related cryptdin-6/12", "tax_id": 10090, "disease": "", "pathway": " (mmu:13240)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1500163;33483420;7927786;8188287", "class_list": "", "function": "Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse-virulent S.typhimurium 14028S. Probably contributes to the antimicrobial barrier function of the small bowel mucosa., [UniProtKB, PubMed, PubMed]; The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells. Erratum:[Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2111936118. doi: 10.1073/pnas.2111936118. 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Defcr16", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-defensin 16; Defensin-related cryptdin-16", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7927786;8188287", "class_list": "", "function": "Probably contributes to the antimicrobial barrier function of the small bowel mucosa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50714-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50715-1", "uniprot_id": "DFA31_MOUSE", "mass": 10055.0, "length": 91, "protein_name": "Alpha-defensin 31", "gene_name": "Defa31", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Defa31; Defa-rs7; Defcr-rs7", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-defensin 31; Alpha-defensin-related sequence 7; CRS4C2; Cryptdin-related protein 4C-2; Defensin-related cryptdin-related sequence 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15235601;7896294", "class_list": "", "function": "Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats (PubMed:7896294). Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins (PubMed:7896294). It may have microbicidal activities (PubMed:15235601)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64109;Q68VH1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50715-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51656-1", "uniprot_id": "DHB1_MOUSE", "mass": 36785.0, "length": 344, "protein_name": "17-beta-hydroxysteroid dehydrogenase type 1", "gene_name": "Hsd17b1", "organism": "Mouse", "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 1", "refseq_ac": "NP_034605", "gene_names_uniprotkb": "Hsd17b1; Edh17b1", "gene_names_refseq": "17HSDB1; 17beta-HSD; E2DH; Hsd17b1; Hsd17ba", "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 1; 1.1.1.51; 1.1.1.62; 17-beta-HSD 1; Estradiol 17-beta-dehydrogenase 1", "protein_names_refseq": "17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; estradiol 17-beta-dehydrogenase 1", "tax_id": 10090, "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008)", "pathway": " (mmu:15485); (R-MMU-193144)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "38785348;8612620;9658408", "class_list": "", "function": "Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:9658408). Also has 20-alpha-HSD activity. Uses preferentially NADH (By similarity)., [UniProtKB, PubMed, UniProtKB]; HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis but Not in Adults., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.300;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;1.1.1.330;1.1.1.270;1.1.1.210;1.1.1.n12;1.1.1.51;1.1.1.64;1.1.1.-;1.1.1.105;1.1.1.209", "go_molecular_function": "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0005496 steroid binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0060612 adipose tissue development;GO:0007040 lysosome organization;GO:0006703 estrogen biosynthetic process;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56386-1", "uniprot_id": "DEFB1_MOUSE", "mass": 7749.0, "length": 69, "protein_name": "Beta-defensin 1", "gene_name": "Defb1", "organism": "Mouse", "refseq_name": "beta-defensin 1 precursor", "refseq_ac": "NP_031869", "gene_names_uniprotkb": "Defb1", "gene_names_refseq": "BD-1; Defb1", "protein_names_uniprotkb": "Beta-defensin 1; BD-1; Defensin, beta 1; mBD-1", "protein_names_refseq": "beta-defensin 1 precursor; beta-defensin 1", "tax_id": 10090, "disease": "pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13214); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10922379;31881038;9287114", "class_list": "", "function": "Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility., [UniProtKB, UniProtKB]; Results found that Foxa2 is involved in the transcriptional regulation of DEFB1, and downregulation of DEFB1 due to suppression of Foxa2 expression is likely to contribute to increased infection risk in the Th2-dominated airway inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0097225 sperm midpiece;GO:1990742 microvesicle", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61804-1", "uniprot_id": "DAD1_MOUSE", "mass": 12497.0, "length": 113, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "Dad1", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "refseq_ac": "NP_001106829", "gene_names_uniprotkb": "Dad1", "gene_names_refseq": "Dad1", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; DAD-1; Defender against cell death 1; Oligosaccharyl transferase subunit DAD1", "protein_names_refseq": "DAD-1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; oligosaccharyl transferase subunit DAD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13135); (R-MMU-9768727); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "31219806;34428180;7737422;9121464", "class_list": "glycogene", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08552;O70364;P46966;P46968;Q3V3W6;Q96GB7", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009101 glycoprotein biosynthetic process;GO:0031647 regulation of protein stability;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61804-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82020-1", "uniprot_id": "DEFB2_MOUSE", "mass": 7820.0, "length": 71, "protein_name": "Beta-defensin 2", "gene_name": "Defb2", "organism": "Mouse", "refseq_name": "beta-defensin 2 precursor", "refseq_ac": "NP_034160", "gene_names_uniprotkb": "Defb2", "gene_names_refseq": "BD-2; Defb2", "protein_names_uniprotkb": "Beta-defensin 2; BD-2; Defensin, beta 2; mBD-2", "protein_names_refseq": "beta-defensin 2 precursor; beta-defensin 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13215)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12411706;24625812;25573055;28622393;36324077;36542690;9923615", "class_list": "", "function": "Acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4, inducing up-regulation of costimulatory molecules and dendritic cell maturation, [RefSeq, PubMed]; Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease. Publication Status: Online-Only, [RefSeq, PubMed]; Has bactericidal activity., [UniProtKB]; Human beta-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling., [RefSeq, PubMed]; Immunomodulatory effects of beta-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Mouse urothelium produces mBD2 in response to intravesicular BCG as a defense mechanism against BCG, [RefSeq, PubMed]; NOD2-mediated beta-defensin 2 regulation contributes to the protection against NTHi-induced otitis media Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0042742 defense response to bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P82020-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q059Y8-1", "uniprot_id": "DCST1_MOUSE", "mass": 84332.0, "length": 732, "protein_name": "E3 ubiquitin-protein ligase DCST1", "gene_name": "Dcst1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase DCST1", "refseq_ac": "NP_084250", "gene_names_uniprotkb": "Dcst1", "gene_names_refseq": "A330106H01Rik; Dcst1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DCST1; 2.3.2.27; DC-STAMP domain-containing protein 1; RING-type E3 ubiquitin transferase", "protein_names_refseq": "DC-STAMP domain-containing protein 1; E3 ubiquitin-protein ligase DCST1; RING-type E3 ubiquitin transferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:77772)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "33871360;35393517", "class_list": "", "function": "E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling., [UniProtKB, UniProtKB]; Essential sperm cell-surface protein required for sperm-egg fusion and fertilization., [UniProtKB, PubMed, PubMed]; Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transmembrane protein. A similar gene in human has been associated with dendritic cells. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0045087 innate immune response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q059Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q30KM9-1", "uniprot_id": "DFB43_MOUSE", "mass": 8252.0, "length": 69, "protein_name": "Beta-defensin 43", "gene_name": "Defb43", "organism": "Mouse", "refseq_name": "beta-defensin 43 precursor", "refseq_ac": "NP_001034210", "gene_names_uniprotkb": "Defb43", "gene_names_refseq": "BD-43; Defb43; EG654458; mBD-43", "protein_names_uniprotkb": "Beta-defensin 43; BD-43; Defensin, beta 43; mBD-43", "protein_names_refseq": "beta-defensin 43 precursor; beta-defensin 43", "tax_id": 10090, "disease": "", "pathway": " (mmu:654458); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has bactericidal activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q30KM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q30KN3-1", "uniprot_id": "DFB33_MOUSE", "mass": 7105.0, "length": 62, "protein_name": "Beta-defensin 33", "gene_name": "Defb33", "organism": "Mouse", "refseq_name": "beta-defensin 33 precursor", "refseq_ac": "NP_001034208", "gene_names_uniprotkb": "Defb33", "gene_names_refseq": "BD-33; Defb33; EG654453", "protein_names_uniprotkb": "Beta-defensin 33; BD-33; Defensin, beta 33; mBD-33", "protein_names_refseq": "beta-defensin 33 precursor; beta-defensin 33", "tax_id": 10090, "disease": "", "pathway": " (mmu:654453)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q30KN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q30KN8-1", "uniprot_id": "DFB25_MOUSE", "mass": 7961.0, "length": 71, "protein_name": "Beta-defensin 25", "gene_name": "Defb25", "organism": "Mouse", "refseq_name": "beta-defensin 25 precursor", "refseq_ac": "NP_001034211", "gene_names_uniprotkb": "Defb25", "gene_names_refseq": "BD-25; Defb25; mBD-25", "protein_names_uniprotkb": "Beta-defensin 25; BD-25; Defensin, beta 25; mBD-25", "protein_names_refseq": "beta-defensin 25 precursor; beta-defensin 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:654459); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0090026 positive regulation of monocyte chemotaxis;GO:0032722 positive regulation of chemokine production;GO:0032755 positive regulation of interleukin-6 production;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q30KN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q30KP3-1", "uniprot_id": "DFB20_MOUSE", "mass": 11039.0, "length": 96, "protein_name": "Beta-defensin 20", "gene_name": "Defb20", "organism": "Mouse", "refseq_name": "beta-defensin 20 precursor", "refseq_ac": "NP_795924", "gene_names_uniprotkb": "Defb20", "gene_names_refseq": "9230107O10Rik; BD-20; Defb20; mBD-20", "protein_names_uniprotkb": "Beta-defensin 20; BD-20; Defensin, beta 20; mBD-20", "protein_names_refseq": "beta-defensin 20 precursor; beta-defensin 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:319579)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16033865;33060057", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]; Mouse defensin beta 20 (Defb20) is expressed specifically in the caput region of the epididymis and regulated by androgen and testicular factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5A7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0009611 response to wounding;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q30KP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q30KP5-1", "uniprot_id": "DFB18_MOUSE", "mass": 9887.0, "length": 85, "protein_name": "Beta-defensin 18", "gene_name": "Defb18", "organism": "Mouse", "refseq_name": "beta-defensin 18 precursor", "refseq_ac": "NP_001034212", "gene_names_uniprotkb": "Defb18", "gene_names_refseq": "BD-18; Defb18; EG654460; mBD-18", "protein_names_uniprotkb": "Beta-defensin 18; BD-18; Defensin, beta 18; mBD-18", "protein_names_refseq": "beta-defensin 18 precursor; beta-defensin 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:654460); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q30KP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q30KP6-1", "uniprot_id": "DFB41_MOUSE", "mass": 7663.0, "length": 65, "protein_name": "Beta-defensin 41", "gene_name": "Defb41", "organism": "Mouse", "refseq_name": "beta-defensin 41 isoform 2 precursor", "refseq_ac": "NP_001035116", "gene_names_uniprotkb": "Defb41; Defb16; Defb17; Gm15386", "gene_names_refseq": "9230102D03Rik; BD-17; Bd-41; Defb16; Defb17; Defb41; Gm15386", "protein_names_uniprotkb": "Beta-defensin 41; BD-41; Defensin, beta 41; mBD-41", "protein_names_refseq": "beta-defensin 16; beta-defensin 17; beta-defensin 41 isoform 2 precursor; defensin beta 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:77673)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16023745;16033865;26987518", "class_list": "", "function": "Defb41 and Defb42 are suggested to have a role in the antimicrobial protection of sperm and urogenital tract epithelia., [RefSeq, PubMed]; Function in sperm maturation, [RefSeq, PubMed]; Has bactericidal activity., [UniProtKB, UniProtKB]; Isoform 2 may play a role in the antimicrobial protection of sperm and urogenital tract epithelia., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZ55;Q8C1G4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q30KP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3L180-1", "uniprot_id": "DFA26_MOUSE", "mass": 10514.0, "length": 93, "protein_name": "Alpha-defensin 26", "gene_name": "Defa26", "organism": "Mouse", "refseq_name": "alpha-defensin 26 precursor", "refseq_ac": "NP_001073402", "gene_names_uniprotkb": "Defa26; Defcr26", "gene_names_refseq": "Defa26; Defcr26", "protein_names_uniprotkb": "Alpha-defensin 26; Defensin-related cryptdin-26", "protein_names_refseq": "alpha-defensin 26 precursor; alpha-defensin 26; defensin-related cryptdin-26; testis defensin", "tax_id": 10090, "disease": "", "pathway": " (mmu:626708); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15494476", "class_list": "", "function": "May have microbicidal activities., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3L180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q45VN2-1", "uniprot_id": "DFA20_MOUSE", "mass": 10601.0, "length": 95, "protein_name": "Alpha-defensin 20", "gene_name": "Defa20", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041890 precursor", "refseq_ac": "NP_001170992", "gene_names_uniprotkb": "Defa20; Defcr20", "gene_names_refseq": "Cryptdin-4; Defa20; Defa32; Defcr20; Gm15308", "protein_names_uniprotkb": "Alpha-defensin 20; Cryptdin-4; Defensin-related cryptdin-20", "protein_names_refseq": "Alpha-defensin 20; novel defensin-related cryptidin; uncharacterized protein LOC100041890 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041890); (mmu:68009); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May have microbicidal activities., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH68", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0042582 azurophil granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q45VN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZF3-1", "uniprot_id": "DDX49_MOUSE", "mass": 54094.0, "length": 480, "protein_name": "Probable ATP-dependent RNA helicase DDX49", "gene_name": "Ddx49", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX49", "refseq_ac": "NP_001020093", "gene_names_uniprotkb": "Ddx49", "gene_names_refseq": "Ddx49; R27090_2", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX49; 3.6.4.13; DEAD box protein 49", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 27; DEAD box protein 49; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 49; probable ATP-dependent RNA helicase DDX49", "tax_id": 10090, "disease": "", "pathway": " (mmu:234374); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "25428506;25605945;34428180", "class_list": "", "function": "ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including the regulation of mRNA export and the levels of pre-ribosomal RNA. Regulates the stability and synthesis of pre-ribosomal RNA and thereby regulates cell proliferation. Also possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;2.1.1.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.1.13.-;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0006364 rRNA processing;GO:0044357 regulation of rRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4FZF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q58NB6-1", "uniprot_id": "DHRS9_MOUSE", "mass": 35242.0, "length": 319, "protein_name": "Dehydrogenase/reductase SDR family member 9", "gene_name": "Dhrs9", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 9 precursor", "refseq_ac": "NP_780721", "gene_names_uniprotkb": "Dhrs9", "gene_names_refseq": "C730025I08Rik; Dhrs9; Rdh15", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 9; 1.1.1.105; 1.1.1.209; 1.1.1.53; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; Retinol dehydrogenase; Short-chain dehydrogenase/reductase retSDR8", "protein_names_refseq": "3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; 3alpha-HSD; dehydrogenase/reductase (SDR family) member 9; dehydrogenase/reductase SDR family member 9 precursor; epithelial retinol dehydrogenase; short-chain dehydrogenase/reductase retSDR8", "tax_id": 10090, "disease": "", "pathway": " (mmu:241452); (R-MMU-2453902); (R-MMU-5365859)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10800688;30679156;31219806", "class_list": "", "function": "3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Also plays a role in the biosynthesis of retinoic acid. Can utilize both NADH and NADPH., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGC7", "ec_number_list": "1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;1.1.1.105;1.1.1.315;1.1.1.209;1.1.1.n12;1.1.1.1;1.1.1.66;1.1.1.-;1.1.1.300", "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016491 oxidoreductase activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002138 retinoic acid biosynthetic process;GO:0042904 9-cis-retinoic acid biosynthetic process;GO:0008209 androgen metabolic process;GO:0008202 steroid metabolic process;GO:0042448 progesterone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q58NB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5G864-1", "uniprot_id": "DFA25_MOUSE", "mass": 10457.0, "length": 92, "protein_name": "Alpha-defensin 25", "gene_name": "Defa25", "organism": "Mouse", "refseq_name": "alpha-defensin 25 precursor", "refseq_ac": "NP_031875", "gene_names_uniprotkb": "Defa25; Defcr25", "gene_names_refseq": "Defa25; Defcr-2; Defcr25; Defcr2", "protein_names_uniprotkb": "Alpha-defensin 25; Defensin-related cryptdin-25", "protein_names_refseq": "alpha-defensin 25 precursor; alpha-defensin 25; defensin related cryptdin 2; defensin-related cryptdin-25", "tax_id": 10090, "disease": "", "pathway": " (mmu:13236); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15494476", "class_list": "", "function": "May have microbicidal activities., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5G864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5G865-1", "uniprot_id": "DFA24_MOUSE", "mass": 10327.0, "length": 93, "protein_name": "Alpha-defensin 24", "gene_name": "Defa24", "organism": "Mouse", "refseq_name": "alpha-defensin 24 precursor", "refseq_ac": "NP_001019396", "gene_names_uniprotkb": "Defa24; Defcr24", "gene_names_refseq": "Defa24; Defcr24", "protein_names_uniprotkb": "Alpha-defensin 24; Defensin-related cryptdin-24", "protein_names_refseq": "alpha-defensin 24 precursor; alpha-defensin 24; defensin-related cryptdin-24", "tax_id": 10090, "disease": "", "pathway": " (mmu:503491); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15494476", "class_list": "", "function": "May have microbicidal activities., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5G865-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M8N4-1", "uniprot_id": "D39U1_MOUSE", "mass": 31458.0, "length": 293, "protein_name": "Epimerase family protein SDR39U1", "gene_name": "Sdr39u1", "organism": "Mouse", "refseq_name": "epimerase family protein SDR39U1 isoform 1", "refseq_ac": "NP_001076444", "gene_names_uniprotkb": "Sdr39u1", "gene_names_refseq": "2310014G06Rik; Sdr39u1", "protein_names_uniprotkb": "Epimerase family protein SDR39U1; 1.1.1.-; Short-chain dehydrogenase/reductase family 39U member 1", "protein_names_refseq": "epimerase family protein SDR39U1 isoform 1; epimerase family protein SDR39U1", "tax_id": 10090, "disease": "", "pathway": " (mmu:654795)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;34428180;37507081", "class_list": "", "function": "Putative NADP-dependent oxidoreductase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V467;Q8BWX0", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5M8N4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0R4-1", "uniprot_id": "DDX56_MOUSE", "mass": 61212.0, "length": 546, "protein_name": "Probable ATP-dependent RNA helicase DDX56", "gene_name": "Ddx56", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX56 isoform 1", "refseq_ac": "NP_080814", "gene_names_uniprotkb": "Ddx56; D11Ertd619e; Noh61", "gene_names_refseq": "2600001H07Rik; D11Ertd619e; Ddx56; Noh61", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX56; 3.6.4.13; ATP-dependent 61 kDa nucleolar RNA helicase; DEAD box protein 56", "protein_names_refseq": "ATP-dependent 61 kDa nucleolar RNA helicase; DEAD (Asp-Glu-Ala-Asp) box polypeptide 56; DEAD box protein 56; DEAD-box RNA helicase; nucleolar RNA helicase homolog; probable ATP-dependent RNA helicase DDX56 isoform 1; probable ATP-dependent RNA helicase DDX56", "tax_id": 10090, "disease": "", "pathway": " (mmu:52513)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;30084848;32703285;34428180;35723050", "class_list": "", "function": "DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway., [RefSeq, PubMed]; Ddx56 maintains proliferation of mouse embryonic stem cells via ribosome assembly and interaction with the Oct4/Sox2 complex. Publication Status: Online-Only, [RefSeq, PubMed]; Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization. Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:32703285). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (PubMed:32703285). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3. Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5. May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0035613 RNA stem-loop binding;GO:0003724 RNA helicase activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0051607 defense response to virus;GO:0006364 rRNA processing;GO:0032480 negative regulation of type I interferon production;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D0R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PE54-1", "uniprot_id": "DHX40_MOUSE", "mass": 88530.0, "length": 779, "protein_name": "Probable ATP-dependent RNA helicase DHX40", "gene_name": "Dhx40", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DHX40", "refseq_ac": "NP_080467", "gene_names_uniprotkb": "Dhx40", "gene_names_refseq": "2410016C14Rik; ARG147; DDX40; Dhx40; PAD", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DHX40; 3.6.4.13; DEAH box protein 40", "protein_names_refseq": "DEAH (Asp-Glu-Ala-His) box polypeptide 40; DEAH box protein 40; probable ATP-dependent RNA helicase DHX40", "tax_id": 10090, "disease": "", "pathway": " (mmu:67487)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probable ATP-dependent RNA helicase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPH2;Q8CD88;Q9CWN3", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0034458 3'-5' RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PE54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61655-1", "uniprot_id": "DD19A_MOUSE", "mass": 53933.0, "length": 478, "protein_name": "ATP-dependent RNA helicase DDX19A", "gene_name": "Ddx19a", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX19A isoform 1", "refseq_ac": "NP_031942", "gene_names_uniprotkb": "Ddx19a; Ddx19; Eif4a-rs1", "gene_names_refseq": "DBP5; Ddx19a; Ddx19; Eif4a-rs1", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX19A; 3.6.4.13; DEAD box RNA helicase DEAD5; DEAD box protein 19A; Eukaryotic translation initiation factor 4A-related sequence 1; mDEAD5", "protein_names_refseq": "ATP-dependent RNA helicase DDX19A isoform 1; ATP-dependent RNA helicase DDX19A; DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a; DEAD box RNA helicase DEAD5; DEAD box protein 19A; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19; Ddx19-like protein; eukaryotic translation initiation factor 4A-related sequence 1; mDEAD5", "tax_id": 10090, "disease": "", "pathway": " (mmu:13680)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;25585691;33823549;8144024", "class_list": "", "function": "A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation., [RefSeq, PubMed]; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins., [UniProtKB, UniProtKB]; Ddx19 is an RNA export factor required for nuclear import of the SRF coactivator MKL1 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543M2;Q921R0", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0010043 response to zinc ion;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64016-1", "uniprot_id": "DFA17_MOUSE", "mass": 9349.0, "length": 82, "protein_name": "Alpha-defensin 17", "gene_name": "Defa17", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Defa17; Defcr17", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-defensin 17; CRYP17; Defensin-related cryptdin-17", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "7927786", "class_list": "", "function": "Probably contributes to the antimicrobial barrier function of the small bowel mucosa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P5D3-1", "uniprot_id": "DHX57_MOUSE", "mass": 155762.0, "length": 1388, "protein_name": "Putative ATP-dependent RNA helicase DHX57", "gene_name": "Dhx57", "organism": "Mouse", "refseq_name": "putative ATP-dependent RNA helicase DHX57 isoform 1", "refseq_ac": "NP_001157231", "gene_names_uniprotkb": "Dhx57", "gene_names_refseq": "Dhx57", "protein_names_uniprotkb": "Putative ATP-dependent RNA helicase DHX57; 3.6.4.13; DEAH box protein 57", "protein_names_refseq": "DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 homolog; DEAH box protein 57; putative ATP-dependent RNA helicase DHX57 isoform 1; putative ATP-dependent RNA helicase DHX57", "tax_id": 10090, "disease": "", "pathway": " (mmu:106794)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;25428506;34428180;35820727", "class_list": "", "function": "Probable ATP-binding RNA helicase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS93;Q6NZK4;Q6P1B4;Q8BI63;Q8BIA2;Q8R360", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6P5D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGN3-1", "uniprot_id": "DCLK2_MOUSE", "mass": 82979.0, "length": 756, "protein_name": "Serine/threonine-protein kinase DCLK2", "gene_name": "Dclk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase DCLK2 isoform 1", "refseq_ac": "NP_001182425", "gene_names_uniprotkb": "Dclk2; Dcamkl2", "gene_names_refseq": "6330415M09Rik; CL2; CLICK2; Click-II; Dcamkl2; Dclk2", "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK2; 2.7.11.1; CL2; CLICK-II; CLICK2; CaMK-like CREB regulatory kinase 2; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2", "protein_names_refseq": "caMK-like CREB regulatory kinase 2; doublecortin and CaM kinase-like 2; doublecortin-like and CAM kinase-like 2; serine/threonine-protein kinase DCLK2 isoform 1; serine/threonine-protein kinase DCLK2", "tax_id": 10090, "disease": "dyslexia (Disease Ontology:DOID:4428)", "pathway": " (mmu:70762)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16628014;16684769;16869982;18075264;19342486;20236041;21750661;25428506;34428180;35820727;38513137", "class_list": "", "function": "Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf., [RefSeq, PubMed]; Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1EDG7;Q1EDG8;Q4H483;Q4W8V1;Q8BUU0;Q8BX25", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:1900181 negative regulation of protein localization to nucleus;GO:0021766 hippocampus development;GO:0034504 protein localization to nucleus;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PGN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TU36-1", "uniprot_id": "DFB50_MOUSE", "mass": 8058.0, "length": 73, "protein_name": "Beta-defensin 50", "gene_name": "Defb50", "organism": "Mouse", "refseq_name": "beta-defensin 50 precursor", "refseq_ac": "NP_951022", "gene_names_uniprotkb": "Defb50; Defb37; Pbd1", "gene_names_refseq": "BD-50; Defb50; Pbd1; mBD-50", "protein_names_uniprotkb": "Beta-defensin 50; BD-50; Defensin, beta 37; Defensin, beta 50; Prostate beta-defensin 1; mBD-50", "protein_names_refseq": "beta-defensin 50 precursor; beta-defensin 50; defensin, beta 37; prostate beta defensin 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:387334)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14659016;16033865", "class_list": "", "function": "Has bactericidal activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q30KM7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TU36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMD2-1", "uniprot_id": "DFB37_MOUSE", "mass": 7052.0, "length": 62, "protein_name": "Beta-defensin 37", "gene_name": "Defb37", "organism": "Mouse", "refseq_name": "beta-defensin 37 precursor", "refseq_ac": "NP_859011", "gene_names_uniprotkb": "Defb37", "gene_names_refseq": "BD-37; Defb37", "protein_names_uniprotkb": "Beta-defensin 37; BD-37; Defensin, beta 37; mBD-37", "protein_names_refseq": "beta-defensin 37 precursor; beta-defensin 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:353320)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14718547", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TMD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNJ0-1", "uniprot_id": "DCSTP_MOUSE", "mass": 53876.0, "length": 470, "protein_name": "Dendritic cell-specific transmembrane protein", "gene_name": "Dcstamp", "organism": "Mouse", "refseq_name": "dendritic cell-specific transmembrane protein isoform 3", "refseq_ac": "NP_001276437", "gene_names_uniprotkb": "Dcstamp; Tm7sf4", "gene_names_refseq": "4833414I07Rik; DC-STAMP; Dcstamp; FIND; Tm7sf4; mDC-STAMP", "protein_names_uniprotkb": "Dendritic cell-specific transmembrane protein; DC-STAMP; Dendrocyte-expressed seven transmembrane protein; Transmembrane 7 superfamily member 4; mDC-STAMP", "protein_names_refseq": "dendritic cell-specific transmembrane protein isoform 3; dendritic cell-specific transmembrane protein; dentrocyte expressed seven transmembrane protein; transmembrane 7 superfamily member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:75766)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15452179;15601667;16061724;16937266;17164993;17713547;18653699;18952287;20039274;21750661;22337159;28939042;31641985;32210715;35445493", "class_list": "", "function": "Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis. Publication Status: Online-Only, [RefSeq, PubMed]; DC-STAMP has an essential role in osteoclastogenesis., [RefSeq, PubMed]; Hypoxia-induced factor 1alpha promotes osteotomy-induced regional acceleratory phenomenon via DC-STAMP mediated membrane fusion., [RefSeq, PubMed]; Multinuclear macrophages of BCG-infected mice express CD antigens and DC-STAMP in the process of fusion., [RefSeq, PubMed]; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; These results suggested that hyperphosphatemia in the patients with CKD suppresses bone resorption by inhibiting osteoclastogenesis, and this impairs the regulation of bone metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RT61;Q6R315;Q7TNI9;Q9D619", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0034241 positive regulation of macrophage fusion;GO:0045780 positive regulation of bone resorption;GO:0045657 positive regulation of monocyte differentiation;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7TNJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNV7-1", "uniprot_id": "DFB38_MOUSE", "mass": 7443.0, "length": 63, "protein_name": "Beta-defensin 38", "gene_name": "Defb38", "organism": "Mouse", "refseq_name": "beta-defensin 38 precursor", "refseq_ac": "NP_898857", "gene_names_uniprotkb": "Defb38", "gene_names_refseq": "BD-38; Defb38", "protein_names_uniprotkb": "Beta-defensin 38; BD-38; Defensin, beta 38; mBD-38", "protein_names_refseq": "beta-defensin 38 precursor; beta-defensin 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:360212)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14718547", "class_list": "", "function": "Synthetic Defb38 kills both Gram-negative (E.coli and P.aeruginosa) and Gram-positive (E.faecium) bacteria., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TNV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNV8-1", "uniprot_id": "DFB34_MOUSE", "mass": 9268.0, "length": 81, "protein_name": "Beta-defensin 34", "gene_name": "Defb34", "organism": "Mouse", "refseq_name": "beta-defensin 34 precursor", "refseq_ac": "NP_898856", "gene_names_uniprotkb": "Defb34", "gene_names_refseq": "BD-34; Defb34", "protein_names_uniprotkb": "Beta-defensin 34; BD-34; Defensin, beta 34; mBD-34", "protein_names_refseq": "beta-defensin 34 precursor; beta-defensin 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:360211)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14718547", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0001530 lipopolysaccharide binding;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:1990742 microvesicle", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TNV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNV9-1", "uniprot_id": "DFB14_MOUSE", "mass": 7718.0, "length": 67, "protein_name": "Beta-defensin 14", "gene_name": "Defb14", "organism": "Mouse", "refseq_name": "beta-defensin 14 precursor", "refseq_ac": "NP_898847", "gene_names_uniprotkb": "Defb14", "gene_names_refseq": "BD-14; Defb14", "protein_names_uniprotkb": "Beta-defensin 14; BD-14; Defensin, beta 14; mBD-14", "protein_names_refseq": "beta-defensin 14 precursor; beta-defensin 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:244332); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18167348;18180295;20483750;29253819;29723492", "class_list": "", "function": "Although murine beta-defensin 14 might affect local skin microbial communities, it may further affect other healing parameters. Indeed, exogenously administered murine beta-defensin 14 directly delayed mouse primary keratinocyte scratch wound closure in vitro., [RefSeq, PubMed]; Beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants, [RefSeq, PubMed]; Both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3., [RefSeq, PubMed]; Chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds, [RefSeq, PubMed]; Has antibacterial activity., [UniProtKB]; This work demonstrates that mouse beta-defensin-14 can promote the maturation of dendritic cells in which TLR-4 is possibly involved, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BD1", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TNV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGW9-1", "uniprot_id": "DFB29_MOUSE", "mass": 9067.0, "length": 78, "protein_name": "Beta-defensin 29", "gene_name": "Defb29", "organism": "Mouse", "refseq_name": "beta-defensin 29 precursor", "refseq_ac": "NP_001001444", "gene_names_uniprotkb": "Defb29", "gene_names_refseq": "0610030I09Rik; BD-29; Defb29; mBD-29", "protein_names_uniprotkb": "Beta-defensin 29; BD-29; Defensin, beta 29; mBD-29", "protein_names_refseq": "beta-defensin 29 precursor; beta-defensin 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:75400)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23765988", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH65-1", "uniprot_id": "DEN6A_MOUSE", "mass": 68967.0, "length": 605, "protein_name": "Protein DENND6A", "gene_name": "Dennd6a", "organism": "Mouse", "refseq_name": "protein DENND6A isoform a", "refseq_ac": "NP_001127937", "gene_names_uniprotkb": "Dennd6a", "gene_names_refseq": "Dennd6a; Fam116a", "protein_names_uniprotkb": "Protein DENND6A; DENN domain-containing protein 6A", "protein_names_refseq": "DENN domain-containing protein 6A; DENN/MADD domain containing 6A; family with sequence similarity 116, member A; protein DENND6A isoform a; protein DENND6A; protein FAM116A", "tax_id": 10090, "disease": "", "pathway": " (mmu:211922); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21330364;21750661;31219806;35820727", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UX21;Q6KAP4;Q8BSG0;Q8C4Z7;Q8K2E8;Q8R136", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BH65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BNI4-1", "uniprot_id": "DERL2_MOUSE", "mass": 27640.0, "length": 239, "protein_name": "Derlin-2", "gene_name": "Derl2", "organism": "Mouse", "refseq_name": "derlin-2 isoform b", "refseq_ac": "NP_001278075", "gene_names_uniprotkb": "Derl2; Der2; Flana", "gene_names_refseq": "CGI-101; Derl2; Derlin-2; F-lana; Flana", "protein_names_uniprotkb": "Derlin-2; Degradation in endoplasmic reticulum protein 2; Der1-like protein 2; F-LANa", "protein_names_refseq": "carcinoma related; degradation in endoplasmic reticulum protein 2; der1-like protein 2; derlin 2; derlin-2 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:116891); (R-MMU-382556); (R-MMU-5358346); (R-MMU-9931269)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11500051;16186509;16449189;21750661;22016385;25009997;29167172;34428180;35820727", "class_list": "", "function": "Derlin-2 is part of a protein quality control mechanism that can rescue glomerular injury attributable to impaired protein folding pathways in the endoplasmic reticulum., [RefSeq, PubMed]; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920I5;Q99J12", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005770 late endosome", "go_biological_process": "GO:0001967 suckling behavior;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BNI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVC1-1", "uniprot_id": "DFB22_MOUSE", "mass": 17709.0, "length": 179, "protein_name": "Beta-defensin 22", "gene_name": "Defb22", "organism": "Mouse", "refseq_name": "beta-defensin 22 precursor", "refseq_ac": "NP_001002791", "gene_names_uniprotkb": "Defb22", "gene_names_refseq": "9230002F21Rik; Defb22", "protein_names_uniprotkb": "Beta-defensin 22; Defb22", "protein_names_refseq": "beta-defensin 126; beta-defensin 22 precursor; beta-defensin 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:442835)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16033865;18787081", "class_list": "", "function": "Probable component of sperm glycocalyx. Likely protects and facilitates transport of sperm in the female reproductive tract. Probably released from the sperm surface during capacitation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030112 glycocalyx;GO:0005576 extracellular region;GO:0009986 cell surface;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BVC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1N8-1", "uniprot_id": "DFA22_MOUSE", "mass": 10548.0, "length": 93, "protein_name": "Alpha-defensin 22", "gene_name": "Defa22", "organism": "Mouse", "refseq_name": "alpha-defensin 22 precursor", "refseq_ac": "NP_997541", "gene_names_uniprotkb": "Defa22; Defcr22", "gene_names_refseq": "Defa22; Defcr22", "protein_names_uniprotkb": "Alpha-defensin 22; Defensin-related cryptdin-22", "protein_names_refseq": "alpha-defensin 22 precursor; alpha-defensin 22; defensin-related cryptdin-22", "tax_id": 10090, "disease": "", "pathway": " (mmu:382059); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15494476;21750661", "class_list": "", "function": "May have microbicidal activities., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody;GO:0042582 azurophil granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C1N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1P2-1", "uniprot_id": "DFA21_MOUSE", "mass": 10507.0, "length": 93, "protein_name": "Alpha-defensin 21", "gene_name": "Defa21", "organism": "Mouse", "refseq_name": "alpha-defensin 21 precursor", "refseq_ac": "NP_899076", "gene_names_uniprotkb": "Defa21; Defcr21", "gene_names_refseq": "2010016B13Rik; Defa21; Defcr21", "protein_names_uniprotkb": "Alpha-defensin 21; Defensin-related cryptdin-21", "protein_names_refseq": "alpha-defensin 21 precursor; alpha-defensin 21; defensin-related cryptdin-21", "tax_id": 10090, "disease": "", "pathway": " (mmu:66298); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15494476", "class_list": "", "function": "May have microbicidal activities., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0042582 azurophil granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C1P2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C2K1-1", "uniprot_id": "DEFI6_MOUSE", "mass": 73454.0, "length": 630, "protein_name": "Differentially expressed in FDCP 6", "gene_name": "Def6", "organism": "Mouse", "refseq_name": "differentially expressed in FDCP 6", "refseq_ac": "NP_081461", "gene_names_uniprotkb": "Def6; Ibp; Slat", "gene_names_refseq": "2410003F05Rik; 6430538D02Rik; Def6; Ibp; Slat2; Slat6; Slat", "protein_names_uniprotkb": "Differentially expressed in FDCP 6; DEF-6; IRF4-binding protein; SWAP-70-like adapter of T-cells", "protein_names_refseq": "DEF-6; IRF-4-binding protein; IRF4-binding protein; SWAP-70-like adapter of T-cells; differentially expressed in FDCP 6", "tax_id": 10090, "disease": "immunodeficiency 87 (Disease Ontology:DOID:0061057); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:23853); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10460589;12648457;12651066;12923183;21750661;25605945;30059200;33373293", "class_list": "", "function": "Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Def6 was first identified in a retroviral gene-trap screen, [RefSeq, PubMed]; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12648457, PubMed:12923183). Can regulate cell morphology in cooperation with activated RAC1 (PubMed:12648457, PubMed:12923183). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (By similarity). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of systemic autoimmunity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1KXF9;B2KF17;Q0VBU6;Q3V3M7;Q80XA9;Q9CRJ2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0098876 vesicle-mediated transport to the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C2K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3I9-1", "uniprot_id": "DIK2B_MOUSE", "mass": 49042.0, "length": 435, "protein_name": "Divergent protein kinase domain 2B", "gene_name": "Dipk2b", "organism": "Mouse", "refseq_name": "divergent protein kinase domain 2B precursor", "refseq_ac": "NP_780437", "gene_names_uniprotkb": "Dipk2b", "gene_names_refseq": "4930578C19Rik; Dipk2b", "protein_names_uniprotkb": "Divergent protein kinase domain 2B; Deleted in autism-related protein 1 homolog", "protein_names_refseq": "UPF0672 protein CXorf36 homolog; deleted in autism-related protein 1 homolog; divergent protein kinase domain 2B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:75905)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34428180;35820727;36210013", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C3I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBY8-1", "uniprot_id": "DCTN4_MOUSE", "mass": 53057.0, "length": 467, "protein_name": "Dynactin subunit 4", "gene_name": "Dctn4", "organism": "Mouse", "refseq_name": "dynactin subunit 4 isoform 1", "refseq_ac": "NP_080578", "gene_names_uniprotkb": "Dctn4", "gene_names_refseq": "1110001K06Rik; 4930547K17Rik; C130039E17Rik; Dctn4; p62", "protein_names_uniprotkb": "Dynactin subunit 4; Dynactin subunit p62", "protein_names_refseq": "dynactin subunit 4 isoform 1; dynactin subunit 4; dynactin subunit p62", "tax_id": 10090, "disease": "", "pathway": " (mmu:67665); (R-MMU-2132295); (R-MMU-3371497); (R-MMU-6807878); (R-MMU-6811436)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "19109891;21186323;22645316;26495903;34197691;34428180", "class_list": "", "function": "Ankyrin-B then interacts with dynactin-4 and dystrophin, whereas dynactin-4 collaborates with dystrophin in coordinating costamere-aligned microtubules, [RefSeq, PubMed]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q923A0;Q9D4X0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005925 focal adhesion;GO:0005938 cell cortex;GO:0001725 stress fiber", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CBY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFK6-1", "uniprot_id": "DEN1C_MOUSE", "mass": 86689.0, "length": 786, "protein_name": "DENN domain-containing protein 1C", "gene_name": "Dennd1c", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 1C isoform 1", "refseq_ac": "NP_705779", "gene_names_uniprotkb": "Dennd1c", "gene_names_refseq": "4432409M07Rik; Dennd1c", "protein_names_uniprotkb": "DENN domain-containing protein 1C; Connecdenn 3", "protein_names_refseq": "DENN domain-containing protein 1C isoform 1; DENN domain-containing protein 1C; DENN/MADD domain containing 1C; connecdenn 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70785); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXF1", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CFK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI75-1", "uniprot_id": "DI3L2_MOUSE", "mass": 97775.0, "length": 870, "protein_name": "DIS3-like exonuclease 2", "gene_name": "Dis3l2", "organism": "Mouse", "refseq_name": "DIS3-like exonuclease 2 isoform 1", "refseq_ac": "NP_001165628", "gene_names_uniprotkb": "Dis3l2", "gene_names_refseq": "4930429A22Rik; 8030493P09Rik; Dis3l2", "protein_names_uniprotkb": "DIS3-like exonuclease 2; 3.1.13.-", "protein_names_refseq": "DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2 isoform 1; DIS3-like exonuclease 2", "tax_id": 10090, "disease": "Perlman syndrome (Disease Ontology:DOID:0060476); nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (mmu:208718)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "17242355;21183079;21750661;23594738;25119025;25605945;26809675;27498873;30084848;31160785;31219806;32457326;34428180;35820727;36210013;36727488;37507081", "class_list": "", "function": "3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation., [UniProtKB, PubMed, HAMAP, PubMed]; 7SB ribosomal RNA can be oligoadenylated by an unknown enzyme and/or oligouridylated by TUT4/7 and subsequently processed by Dis3l2 and Eri1., [RefSeq, PubMed]; DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation., [RefSeq, PubMed]; DIS3L2 ribonuclease degrades terminal-uridylated RNA to ensure oocyte maturation and female fertility., [RefSeq, PubMed]; Dis3l2-mediated decay is a quality control pathway for noncoding RNAs., [RefSeq, PubMed]; Identification of Dis3l2 as the 3'-5' exonuclease responsible for the decay of uridylated pre-let-7 in mouse embryonic stem cells, [RefSeq, PubMed]; Structure of mouse Dis3l2 in complex with an oligoU RNA to mimic the uridylated tail of pre-let-7, [RefSeq, PubMed]; The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMG9", "ec_number_list": "3.6.4.13;3.1.13.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004540 RNA nuclease activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0008285 negative regulation of cell population proliferation;GO:0051301 cell division;GO:0019827 stem cell population maintenance;GO:0051306 mitotic sister chromatid separation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8CI75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K301-1", "uniprot_id": "DDX52_MOUSE", "mass": 67474.0, "length": 598, "protein_name": "Probable ATP-dependent RNA helicase DDX52", "gene_name": "Ddx52", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX52", "refseq_ac": "NP_084372", "gene_names_uniprotkb": "Ddx52; Rok1", "gene_names_refseq": "2700029C06Rik; Ddx52; ROK1", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX52; 3.6.4.13; ATP-dependent RNA helicase ROK1-like; DEAD box protein 52", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 52; DEAD box protein 52; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 52; probable ATP-dependent RNA helicase DDX52", "tax_id": 10090, "disease": "", "pathway": " (mmu:78394); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "25428506;25605945;30779550;31599954;34428180;35820727", "class_list": "", "function": "Required for efficient ribosome biogenesis. May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZY9;Q8BV29", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;2.1.1.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.1.13.-;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K301-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3I8-1", "uniprot_id": "DFB19_MOUSE", "mass": 9568.0, "length": 83, "protein_name": "Beta-defensin 19", "gene_name": "Defb19", "organism": "Mouse", "refseq_name": "beta-defensin 19 precursor", "refseq_ac": "NP_660139", "gene_names_uniprotkb": "Defb19; Defb24; Tdl", "gene_names_refseq": "BD-19; Defb19; Defb24; Tdl; mBD-19", "protein_names_uniprotkb": "Beta-defensin 19; BD-19; Defensin, beta 19; Testis-specific beta-defensin-like protein; mBD-19", "protein_names_refseq": "beta-defensin 19 precursor; beta-defensin 19; beta-defensin 24; testis-specific beta-defensin-like protein", "tax_id": 10090, "disease": "female reproductive system disease (Disease Ontology:DOID:229)", "pathway": " (mmu:246700); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12128228;12617826;16033865;36513070", "class_list": "", "function": "Beta-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility., [RefSeq, PubMed]; Has antibacterial activity., [UniProtKB]; Tdl is specifically expressed in Sertoli cell-lineage in seminiferous cords in embryonic testes, but not in embryonic ovaries after 12.5dpc when the sexual differentiation of gonads is initiated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0L7", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061760 antifungal innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K3I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3U4-1", "uniprot_id": "DFB36_MOUSE", "mass": 7755.0, "length": 67, "protein_name": "Beta-defensin 36", "gene_name": "Defb36", "organism": "Mouse", "refseq_name": "beta-defensin 36 precursor", "refseq_ac": "NP_001032324", "gene_names_uniprotkb": "Defb36", "gene_names_refseq": "BD-36; Defb123; Defb36; mBD-36", "protein_names_uniprotkb": "Beta-defensin 36; BD-36; Defensin, beta 36; mBD-36", "protein_names_refseq": "beta-defensin 36 precursor; beta-defensin 36; defensin beta 123", "tax_id": 10090, "disease": "", "pathway": " (mmu:266620); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11854508;16033865", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGR4;Q3V491", "ec_number_list": "", "go_molecular_function": "GO:0140912 membrane destabilizing activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K3U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4L0-1", "uniprot_id": "DDX54_MOUSE", "mass": 97748.0, "length": 874, "protein_name": "ATP-dependent RNA helicase DDX54", "gene_name": "Ddx54", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX54", "refseq_ac": "NP_082317", "gene_names_uniprotkb": "Ddx54", "gene_names_refseq": "2410015A15Rik; DP97; Ddx54", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX54; 3.6.4.13; DEAD box protein 54", "protein_names_refseq": "ATP-dependent RNA helicase DDX54; DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; DEAD box protein 54", "tax_id": 10090, "disease": "", "pathway": " (mmu:71990)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12080145;17242355;20173027;21183079;23239230;25605945;31599954;34428180", "class_list": "", "function": "Nucleolar RNA helicase that is involved in diverse cellular processes including ribosome biogenesis, DNA damage response, RNA splicing, transcriptional regulation, innate immunity, and nervous system development. Plays an essential role in the formation of the ribosome active site by remodeling rRNA structure and initiating peptidyl transferase center formation. Represses the transcriptional activity of several nuclear receptors. Regulates transcriptome dynamics during DNA damage response. Mechanistically, acts via increased interaction with a well-defined class of pre-mRNAs that contain introns with weak acceptor splice sites, as well as by protein-protein contacts within components of U2 snRNP and spliceosomal B complex. These activities lead to reduced intron retention and enhanced processing rates of its target transcripts. Acts as an inhibitor of type I interferon antiviral response by facilitating ALKBH5-mediated demethylation of specific transcripts (By similarity). Contributes to central nervous system myelination, likely through regulation of oligodendrocyte differentiation and myelin sheath formation (PubMed:23239230)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006396 RNA processing;GO:0006364 rRNA processing;GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K4L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4R9-1", "uniprot_id": "DLGP5_MOUSE", "mass": 90196.0, "length": 808, "protein_name": "Disks large-associated protein 5", "gene_name": "Dlgap5", "organism": "Mouse", "refseq_name": "disks large-associated protein 5 isoform 1", "refseq_ac": "NP_653136", "gene_names_uniprotkb": "Dlgap5; Dlg7; Kiaa0008", "gene_names_refseq": "Dap-5; Dlg7; Dlgap5; Hurp; mKIAA0008", "protein_names_uniprotkb": "Disks large-associated protein 5; DAP-5; Discs large homolog 7; Disks large-associated protein DLG7; HURP; Hepatoma up-regulated protein homolog", "protein_names_refseq": "discs, large homolog 7; discs, large homolog-associated protein 5; disks large-associated protein 5 isoform 1; disks large-associated protein 5; hepatoma up-regulated protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:218977)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12527899;16364248;17242355;18676373;21173113;21183079;21750661;21952136;25428506;25605945;30084848;30779550;34428180", "class_list": "", "function": "Endogenous levels of HURP mRNA were found to be tightly regulated during cell cycle progression and in regenerating mouse liver after partial hepatectomy [HURP], [RefSeq, PubMed]; HURP has an essential function in uterine biology, [RefSeq, PubMed]; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells (By similarity)., [UniProtKB, UniProtKB]; The process of bipolar spindle assembly in the presence of multiple MTOCs in female meiosis resembles the clustering of extra centrosomes during cancer cell division. HURP plays an essential role in both processes., [RefSeq, PubMed]; These results indicate that the HURP gene might be a potential oncogenic gene and capable of enhancing the chemosensitivity of deoxycytosine analogs in NIH3T3 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQL3;Q80VS7;Q8BUC8;Q8BZ79", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031616 spindle pole centrosome;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0007346 regulation of mitotic cell cycle;GO:0023052 signaling;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K4R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZV0-1", "uniprot_id": "DEDD2_MOUSE", "mass": 36786.0, "length": 330, "protein_name": "DNA-binding death effector domain-containing protein 2", "gene_name": "Dedd2", "organism": "Mouse", "refseq_name": "DNA-binding death effector domain-containing protein 2", "refseq_ac": "NP_997560", "gene_names_uniprotkb": "Dedd2; Flame3", "gene_names_refseq": "2410050E11Rik; Dedd2; FLAME-3", "protein_names_uniprotkb": "DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3", "protein_names_refseq": "DED-containing protein FLAME-3; DNA-binding death effector domain-containing protein 2; FADD-like anti-apoptotic molecule 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67379)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11965497;12527898", "class_list": "", "function": "May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569Y9;Q8JZV1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0030262 apoptotic nuclear changes;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8QZV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2I3-1", "uniprot_id": "DFB35_MOUSE", "mass": 7397.0, "length": 63, "protein_name": "Beta-defensin 35", "gene_name": "Defb35", "organism": "Mouse", "refseq_name": "beta-defensin 35 precursor", "refseq_ac": "NP_631970", "gene_names_uniprotkb": "Defb35", "gene_names_refseq": "BD-35; Defb35", "protein_names_uniprotkb": "Beta-defensin 35; BD-35; Defensin, beta 35; mBD-35", "protein_names_refseq": "beta-defensin 35 precursor; beta-defensin 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:246084)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12644567;14718547", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2I4-1", "uniprot_id": "DFB13_MOUSE", "mass": 7520.0, "length": 64, "protein_name": "Beta-defensin 13", "gene_name": "Defb13", "organism": "Mouse", "refseq_name": "beta-defensin 13 precursor", "refseq_ac": "NP_631969", "gene_names_uniprotkb": "Defb13", "gene_names_refseq": "BD-13; Defb13", "protein_names_uniprotkb": "Beta-defensin 13; BD-13; Defensin, beta 13; mBD-13", "protein_names_refseq": "beta-defensin 13 precursor; beta-defensin 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:246083)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12644567;14718547", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4E3", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2I5-1", "uniprot_id": "DFB15_MOUSE", "mass": 8730.0, "length": 79, "protein_name": "Beta-defensin 15", "gene_name": "Defb15", "organism": "Mouse", "refseq_name": "beta-defensin 15 precursor", "refseq_ac": "NP_631968", "gene_names_uniprotkb": "Defb15", "gene_names_refseq": "BD-15; Defb15", "protein_names_uniprotkb": "Beta-defensin 15; BD-15; Defensin, beta 15; mBD-15", "protein_names_refseq": "beta-defensin 15 precursor; beta-defensin 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:246082)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12644567;14718547", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4E5", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0001530 lipopolysaccharide binding;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:1990742 microvesicle", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2I7-1", "uniprot_id": "DFB11_MOUSE", "mass": 8666.0, "length": 77, "protein_name": "Beta-defensin 11", "gene_name": "Defb11", "organism": "Mouse", "refseq_name": "beta-defensin 11 precursor", "refseq_ac": "NP_631967", "gene_names_uniprotkb": "Defb11", "gene_names_refseq": "BD-11; Defb11; Defb8", "protein_names_uniprotkb": "Beta-defensin 11; BD-11; Defensin, beta 11; mBD-11", "protein_names_refseq": "beta-defensin 11 precursor; beta-defensin 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:246081)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12193721;12644567", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]; The epididymis-specific expression pattern of the beta-defensin isoform mBD-11 has been characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499L3", "ec_number_list": "", "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2I8-1", "uniprot_id": "DFB10_MOUSE", "mass": 8393.0, "length": 73, "protein_name": "Beta-defensin 10", "gene_name": "Defb10", "organism": "Mouse", "refseq_name": "beta-defensin 10 precursor", "refseq_ac": "NP_631971", "gene_names_uniprotkb": "Defb10", "gene_names_refseq": "BD-10; Defb10; Defb7", "protein_names_uniprotkb": "Beta-defensin 10; BD-10; Defensin, beta 10; mBD-10", "protein_names_refseq": "beta-defensin 10 precursor; beta-defensin 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:246085)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12644567", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4E8", "ec_number_list": "", "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBZ0-1", "uniprot_id": "DHRSX_MOUSE", "mass": 35957.0, "length": 335, "protein_name": "Polyprenol dehydrogenase", "gene_name": "Dhrsx", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dhrsx; Pscad", "gene_names_refseq": "", "protein_names_uniprotkb": "Polyprenol dehydrogenase; 1.1.1.441; Dehydrogenase/reductase SDR family member on chromosome Y; Dolichal reductase; SCAD family protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-446199)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11731500;26495903", "class_list": "", "function": "Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis. Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol. First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3. It then catalyzes the NADPH-dependent reduction of dolichal into dolichol. May also acts as a positive regulator of starvation-induced autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRV9;Q3TZW6", "ec_number_list": "1.1.1.441", "go_molecular_function": "GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0160196 polyprenol dehydrogenase (NAD+) activity;GO:0160197 dolichal reductase (NADPH) activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005811 lipid droplet", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VBZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCH6-1", "uniprot_id": "DHC24_MOUSE", "mass": 60112.0, "length": 516, "protein_name": "Delta(24)-sterol reductase", "gene_name": "Dhcr24", "organism": "Mouse", "refseq_name": "delta(24)-sterol reductase precursor", "refseq_ac": "NP_444502", "gene_names_uniprotkb": "Dhcr24; Kiaa0018", "gene_names_refseq": "2310076D10Rik; 5830417J06Rik; Dhcr24; mKIAA0018", "protein_names_uniprotkb": "Delta(24)-sterol reductase; 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase", "protein_names_refseq": "3-beta-hydroxysterol delta-24-reductase; delta(24)-sterol reductase precursor; delta(24)-sterol reductase; seladin-1", "tax_id": 10090, "disease": "desmosterolosis (Disease Ontology:DOID:0070654); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (mmu:74754); (R-MMU-6807047); (R-MMU-6807062); (R-MMU-9969901)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11519011;26114596;34428180;37344916;38032198;38649789", "class_list": "", "function": "3beta-hydroxysteroid-Delta24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING., [RefSeq, PubMed]; Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:26114596). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice. Publication Status: Online-Only, [RefSeq, PubMed]; TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQK9;Q91ZD0;Q9CU63", "ec_number_list": "1.3.1.72", "go_molecular_function": "GO:0019899 enzyme binding;GO:0071949 FAD binding;GO:0042605 peptide antigen binding;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0000246 Delta24(24-1) sterol reductase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0061024 membrane organization;GO:0006695 cholesterol biosynthetic process;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHK9-1", "uniprot_id": "DHX36_MOUSE", "mass": 113883.0, "length": 1001, "protein_name": "ATP-dependent DNA/RNA helicase DHX36", "gene_name": "Dhx36", "organism": "Mouse", "refseq_name": "ATP-dependent DNA/RNA helicase DHX36", "refseq_ac": "NP_082412", "gene_names_uniprotkb": "Dhx36; Ddx36; Kiaa1488; Mlel1", "gene_names_refseq": "2810407E23Rik; Ddx36; Dhx36; RHAU; mKIAA1488", "protein_names_uniprotkb": "ATP-dependent DNA/RNA helicase DHX36; 3.6.4.13; DEAD/H box polypeptide 36; DEAH box protein 36; MLE-like protein 1; RNA helicase associated with AU-rich element ARE", "protein_names_refseq": "ATP-dependent DNA/RNA helicase DHX36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; MLE-like protein 1; RNA helicase associated with AU-rich element ARE; probable ATP-dependent RNA helicase DHX36", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:72162); (R-MMU-3134963)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12198572;16452087;21590736;21703541;22422825;25611385;26489465;26495903;31219806;34418053;34428180;34838591;34887587;35675771;36484653", "class_list": "", "function": "DNA/RNA helicase DHX36 is required for late stages of spermatogenesis., [RefSeq, PubMed]; Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5' UTR rG4 unwinding and Anp32e translation., [RefSeq, PubMed]; Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:25611385). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:21590736, PubMed:21703541). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (By similarity). Plays a role in genomic integrity (By similarity). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (By similarity). Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (By similarity) (PubMed:25611385). Plays a role in post-transcriptional regulation (By similarity). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (By similarity). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (By similarity). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (By similarity). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (By similarity). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (By similarity). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541). Required for the early embryonic development and hematopoiesis (PubMed:22422825). Involved in the regulation of cardioblast differentiation and proliferation during heart development (PubMed:26489465). Involved in spermatogonia differentiation (PubMed:25611385). May play a role in ossification (PubMed:21590736)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X8Y4;Q6ZPP7;Q9CSE8", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0032727 positive regulation of interferon-alpha production;GO:2000767 positive regulation of cytoplasmic translation;GO:0051891 positive regulation of cardioblast differentiation;GO:1904582 positive regulation of intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VHK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V70-1", "uniprot_id": "DEFB7_MOUSE", "mass": 8292.0, "length": 71, "protein_name": "Beta-defensin 7", "gene_name": "Defb7", "organism": "Mouse", "refseq_name": "beta-defensin 7 precursor", "refseq_ac": "NP_631966", "gene_names_uniprotkb": "Defb7", "gene_names_refseq": "BD-7; Defb7", "protein_names_uniprotkb": "Beta-defensin 7; BD-7; Defensin, beta 7; mBD-7; mBD7", "protein_names_refseq": "beta-defensin 7 precursor; beta-defensin 7", "tax_id": 10090, "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:246080)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11714914", "class_list": "", "function": "Has bactericidal activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91V70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VV4-1", "uniprot_id": "DEN2D_MOUSE", "mass": 53211.0, "length": 469, "protein_name": "DENN domain-containing protein 2D", "gene_name": "Dennd2d", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 2D isoform 2", "refseq_ac": "NP_001087223", "gene_names_uniprotkb": "Dennd2d", "gene_names_refseq": "2010308M01Rik; Dennd2d", "protein_names_uniprotkb": "DENN domain-containing protein 2D", "protein_names_refseq": "DENN domain-containing protein 2D isoform 2; DENN domain-containing protein 2D; DENN/MADD domain containing 2D", "tax_id": 10090, "disease": "", "pathway": " (mmu:72121); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18299400;20173027;21750661;31219806;34428180", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U028;Q9D831", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91VV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WG7-1", "uniprot_id": "DGKG_MOUSE", "mass": 88523.0, "length": 788, "protein_name": "Diacylglycerol kinase gamma", "gene_name": "Dgkg", "organism": "Mouse", "refseq_name": "diacylglycerol kinase gamma isoform 1", "refseq_ac": "NP_619591", "gene_names_uniprotkb": "Dgkg; Dagk3", "gene_names_refseq": "2900055E17Rik; 90kDa; Dagk3; Dgkg; E430001K23Rik; mKIAA4131", "protein_names_uniprotkb": "Diacylglycerol kinase gamma; 2.7.1.107; 88 kDa diacylglycerol kinase; DAG kinase gamma; DGK-gamma; Diglyceride kinase gamma", "protein_names_refseq": "88 kDa diacylglycerol kinase; DAG kinase gamma; DGK-gamma; diacylglycerol kinase gamma isoform 1; diacylglycerol kinase, gamma 3; diacylglycerol kinase, gamma 90kDa; diglyceride kinase gamma", "tax_id": 10090, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:110197); (R-MMU-114508)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;32033984;33114041;37838036", "class_list": "", "function": "DGKgamma Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCgamma. Publication Status: Online-Only, [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:32033984). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:32033984). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma (PubMed:32033984). Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (PubMed:32033984)., [UniProtKB, UniProtKB, PubMed]; Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma., [RefSeq, PubMed]; Precise Regulation of the Basal PKCgamma Activity by DGKgamma Is Crucial for Motor Coordination. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91WG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WS7-1", "uniprot_id": "DEPD7_MOUSE", "mass": 58479.0, "length": 511, "protein_name": "DEP domain-containing protein 7", "gene_name": "Depdc7", "organism": "Mouse", "refseq_name": "DEP domain-containing protein 7", "refseq_ac": "NP_659053", "gene_names_uniprotkb": "Depdc7", "gene_names_refseq": "Depdc7", "protein_names_uniprotkb": "DEP domain-containing protein 7; Protein TR2/D15", "protein_names_refseq": "DEP domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:211896)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10568747;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN66;Q3UNR5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91WS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZV3-1", "uniprot_id": "DCBD2_MOUSE", "mass": 83774.0, "length": 769, "protein_name": "Discoidin, CUB and LCCL domain-containing protein 2", "gene_name": "Dcbld2", "organism": "Mouse", "refseq_name": "discoidin, CUB and LCCL domain-containing protein 2 isoform 1 precursor", "refseq_ac": "NP_082799", "gene_names_uniprotkb": "Dcbld2; Esdn", "gene_names_refseq": "1700055P21Rik; CLCP1; Dcbld2; Esdn", "protein_names_uniprotkb": "Discoidin, CUB and LCCL domain-containing protein 2; Endothelial and smooth muscle cell-derived neuropilin-like protein", "protein_names_refseq": "discoidin, CUB and LCCL domain-containing protein 2 isoform 1 precursor; discoidin, CUB and LCCL domain-containing protein 2; endothelial and smooth muscle cell-derived neuropilin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73379)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11447234;24177422;30084848;34428180;35929441;38310161", "class_list": "", "function": "CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation., [RefSeq, PubMed]; DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-beta endocytosis through Caveolin-1 in vascular smooth muscle cells. Erratum:[FASEB J. 2023 Sep;37(9):e23150. doi: 10.1096/fj.202301586. PMID: 37594909], [RefSeq, PubMed]; Deletion of Esdn in the mouse interfered with adult and developmental angiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A6X950;Q8BKI4", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91ZV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J56-1", "uniprot_id": "DERL1_MOUSE", "mass": 28835.0, "length": 251, "protein_name": "Derlin-1", "gene_name": "Derl1", "organism": "Mouse", "refseq_name": "derlin-1", "refseq_ac": "NP_077169", "gene_names_uniprotkb": "Derl1; Der1", "gene_names_refseq": "1110021N07Rik; Derl1; Derlin-1", "protein_names_uniprotkb": "Derlin-1; Degradation in endoplasmic reticulum protein 1; Der1-like protein 1", "protein_names_refseq": "degradation in endoplasmic reticulum protein 1; der1-like protein 1; derlin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67819); (R-MMU-382556); (R-MMU-532668); (R-MMU-9931269)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "16186509;16449189;18250455;21183079;22016385;22267725;24160817;25009997;25428506;25428507;25605945;30084848;31219806;34428180;35820727;36528738;37499886;38522486;39080439", "class_list": "", "function": "Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]; Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1., [RefSeq, PubMed]; Derlin-1 promotes diet-induced non-alcoholic fatty liver disease via increasing RIPK3-mediated necroptosis., [RefSeq, PubMed]; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane. This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway., [UniProtKB, UniProtKB]; The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6Z2;Q9D918", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0036502 Derlin-1-VIMP complex;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031398 positive regulation of protein ubiquitination;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q99J56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWT6-1", "uniprot_id": "DDX28_MOUSE", "mass": 59515.0, "length": 540, "protein_name": "Probable ATP-dependent RNA helicase DDX28", "gene_name": "Ddx28", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX28", "refseq_ac": "NP_082314", "gene_names_uniprotkb": "Ddx28", "gene_names_refseq": "2410004K13Rik; Ddx28; Mddx28", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX28; 3.6.4.13; Mitochondrial DEAD box protein 28", "protein_names_refseq": "ATP-dependent RNA helicase Ddx28; DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28; mitochondrial DEAD box protein 28; probable ATP-dependent RNA helicase DDX28", "tax_id": 10090, "disease": "", "pathway": " (mmu:71986)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29187734;30084848;31219806", "class_list": "", "function": "Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBM0;Q3TQM0", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0019843 rRNA binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1B8-1", "uniprot_id": "DCD2C_MOUSE", "mass": 39355.0, "length": 347, "protein_name": "Doublecortin domain-containing protein 2C", "gene_name": "Dcdc2c", "organism": "Mouse", "refseq_name": "doublecortin domain-containing protein 2C isoform 4", "refseq_ac": "NP_001171435", "gene_names_uniprotkb": "Dcdc2c", "gene_names_refseq": "1110015M06Rik; Dcdc2c", "protein_names_uniprotkb": "Doublecortin domain-containing protein 2C", "protein_names_refseq": "doublecortin domain-containing protein 2C isoform 4; doublecortin domain-containing protein 2C; putative doublecortin domain-containing protein ENSP00000382097 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68511)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005815 microtubule organizing center;GO:0036126 sperm flagellum", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D1B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D757-1", "uniprot_id": "DAPL1_MOUSE", "mass": 11813.0, "length": 107, "protein_name": "Death-associated protein-like 1", "gene_name": "Dapl1", "organism": "Mouse", "refseq_name": "death-associated protein-like 1", "refseq_ac": "NP_083999", "gene_names_uniprotkb": "Dapl1; Eeda", "gene_names_refseq": "2310032F03Rik; Dapl1; EEDA", "protein_names_uniprotkb": "Death-associated protein-like 1; Early epithelial differentiation-associated protein", "protein_names_refseq": "death-associated protein-like 1; early epithelial differentiation-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76747)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15920738;19224205;20173027;28334846;30084848;30779550;34428180;34535743;36210013;36841807;36933392", "class_list": "", "function": "Authors show that DAPL1 is a novel regulator of RPE cell proliferation that is important for the maintenance of the RPE as a monolayer. The findings suggest that DAPL1 dysregulation may be involved in abnormal RPE-related proliferative diseases and corresponding retinal dysfunctions in humans., [RefSeq, PubMed]; DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features. Erratum:[Redox Biol. 2025 Dec;88:103938. doi: 10.1016/j.redox.2025.103938. PMID: 41339167], [RefSeq, PubMed]; DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis. Publication Status: Online-Only, [RefSeq, PubMed]; DAPL1 prevents epithelial-mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in the early stages of epithelial differentiation or in apoptosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030371 translation repressor activity;GO:0043022 ribosome binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0097190 apoptotic signaling pathway;GO:0010507 negative regulation of autophagy;GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D757-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8K3-1", "uniprot_id": "DERL3_MOUSE", "mass": 25978.0, "length": 228, "protein_name": "Derlin-3", "gene_name": "Derl3", "organism": "Mouse", "refseq_name": "derlin-3 isoform 1", "refseq_ac": "NP_077760", "gene_names_uniprotkb": "Derl3; Der3; Izp6", "gene_names_refseq": "1810006I20Rik; 1810063P04Rik; Derl3; IZP6; derlin-3", "protein_names_uniprotkb": "Derlin-3; Degradation in endoplasmic reticulum protein 3; Der1-like protein 3; Protein IZP6", "protein_names_refseq": "degradation in endoplasmic reticulum protein 3; der1-like protein 3; derlin-3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70377); (R-MMU-382556); (R-MMU-9931269)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11422294;15215855;19940266;21750661;22016385;22479592;32858914", "class_list": "", "function": "Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice, [RefSeq, PubMed]; Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress. Publication Status: Online-Only, [RefSeq, PubMed]; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation., [UniProtKB, UniProtKB]; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome., [UniProtKB, UniProtKB]; Study describes a potentially protective role for Derl3 in the heart., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9L7;Q99KC6;Q9D954", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:1904153 negative regulation of retrograde protein transport, ER to cytosol;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D8K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9V7-1", "uniprot_id": "DEN6B_MOUSE", "mass": 66588.0, "length": 585, "protein_name": "Protein DENND6B", "gene_name": "Dennd6b", "organism": "Mouse", "refseq_name": "protein DENND6B", "refseq_ac": "NP_081357", "gene_names_uniprotkb": "Dennd6b", "gene_names_refseq": "1700027J05Rik; Dennd6b; Fam116b", "protein_names_uniprotkb": "Protein DENND6B; DENN domain-containing protein 6B", "protein_names_refseq": "DENN domain-containing protein 6B; DENN/MADD domain containing 6B; family with sequence similarity 116, member B; protein DENND6B; protein FAM116B", "tax_id": 10090, "disease": "", "pathway": " (mmu:69440); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21330364;21750661;25428506;30084848;34428180", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSU3", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0055037 recycling endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D9V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAF3-1", "uniprot_id": "DDI1_MOUSE", "mass": 45713.0, "length": 408, "protein_name": "Protein DDI1 homolog 1", "gene_name": "Ddi1", "organism": "Mouse", "refseq_name": "protein DDI1 homolog 1", "refseq_ac": "NP_082218", "gene_names_uniprotkb": "Ddi1", "gene_names_refseq": "1700011N24Rik; Ddi1", "protein_names_uniprotkb": "Protein DDI1 homolog 1; 3.4.23.-", "protein_names_refseq": "DDI1, DNA-damage inducible 1, homolog 1; protein DDI1 homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71829)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29788202;33092996", "class_list": "", "function": "Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice., [RefSeq, PubMed]; Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redundantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The novel observation that DDI1 is expressed in the developing mice brain, with a significant peak at E16.5, strongly suggests that DDI1 has biological functions not yet described that could be of relevance for Angelman syndrome clinical research., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0010498 proteasomal protein catabolic process;GO:0097752 regulation of DNA stability;GO:0072711 cellular response to hydroxyurea", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCP9-1", "uniprot_id": "DAZP2_MOUSE", "mass": 17289.0, "length": 168, "protein_name": "DAZ-associated protein 2", "gene_name": "Dazap2", "organism": "Mouse", "refseq_name": "DAZ-associated protein 2", "refseq_ac": "NP_036003", "gene_names_uniprotkb": "Dazap2; Prtb", "gene_names_refseq": "Brbp; Dazap2; Gcap28; Prtb; gt6-12; mKIAA0058", "protein_names_uniprotkb": "DAZ-associated protein 2; Deleted in azoospermia-associated protein 2; Proline-rich protein expressed in brain; Proline-rich transcript in brain protein", "protein_names_refseq": "DAZ-associated protein 2; deleted in azoospermia-associated protein 2; granule cell antiserum positive 28; proline-rich protein expressed in brain; proline-rich transcript in brain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:23994)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10373015;11787059;14530442;19304756;25605945;25681341;31219806;34428180;35820727", "class_list": "", "function": "Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2)., [RefSeq, PubMed]; In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (PubMed:19304756). Plays a role in stress granule formation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Role as an immediate early, serum-responsive, and adhesion-inducible gene with possible involvement in cell cycle control, adhesion, and proliferation, [RefSeq, PubMed]; This paper reveals that the mouse DAZAP2 homolog interacts with Sox6 and may be involved in the regulation of a cardiac L-type Ca2+ channel., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88675;Q3UVI4", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0050699 WW domain binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0031648 protein destabilization;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DCP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCV6-1", "uniprot_id": "DELE1_MOUSE", "mass": 55430.0, "length": 510, "protein_name": "DAP3-binding cell death enhancer 1", "gene_name": "Dele1", "organism": "Mouse", "refseq_name": "DAP3-binding cell death enhancer 1", "refseq_ac": "NP_077141", "gene_names_uniprotkb": "Dele1; Dele; Kiaa0141", "gene_names_refseq": "0610009O20Rik; 2700004E22Rik; DELE1(L); Dele1; Dele; Kiaa0141", "protein_names_uniprotkb": "DAP3-binding cell death enhancer 1; DAP3-binding cell death enhancer 1, long form; DELE1(L); Death ligand signal enhancer", "protein_names_refseq": "DAP3-binding cell death enhancer 1, long form; DAP3-binding cell death enhancer 1; death ligand signal enhancer", "tax_id": 10090, "disease": "", "pathway": " (mmu:66839); (R-MMU-9840373)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20563667;21750661;28655335;30084848;31219806", "class_list": "", "function": "Dele and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function. Publication Status: Online-Only, [RefSeq, PubMed]; Functionally characterizes the human homolog as a DAP3-binding protein involved in apoptosis mediated by death receptors., [RefSeq, PubMed]; Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (By similarity). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (By similarity). Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (By similarity)., [UniProtKB, UniProtKB]; Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR., [UniProtKB, UniProtKB]; Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0B8", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:1901526 positive regulation of mitophagy;GO:0051260 protein homooligomerization;GO:0006974 DNA damage response;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DCV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPV9-1", "uniprot_id": "DEFB5_MOUSE", "mass": 6970.0, "length": 64, "protein_name": "Beta-defensin 5", "gene_name": "Defb5", "organism": "Mouse", "refseq_name": "beta-defensin 5 precursor", "refseq_ac": "NP_109659", "gene_names_uniprotkb": "Defb5", "gene_names_refseq": "BD-5; Defb5", "protein_names_uniprotkb": "Beta-defensin 5; BD-5; Defensin, beta 5; mBD-5", "protein_names_refseq": "beta-defensin 5 precursor; beta-defensin 5", "tax_id": 10090, "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:81007)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12193721", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]; The epididymis-specific expression pattern of beta-defensin isoform 5 has been characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VQA5", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EPV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JII5-1", "uniprot_id": "DAZP1_MOUSE", "mass": 43214.0, "length": 406, "protein_name": "DAZ-associated protein 1", "gene_name": "Dazap1", "organism": "Mouse", "refseq_name": "DAZ-associated protein 1 isoform b", "refseq_ac": "NP_001116076", "gene_names_uniprotkb": "Dazap1", "gene_names_refseq": "2410042M16Rik; Dazap1; mPrrp", "protein_names_uniprotkb": "DAZ-associated protein 1; Deleted in azoospermia-associated protein 1", "protein_names_refseq": "DAZ-associated protein 1 isoform b; deleted in azoospermia-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70248)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11604102;12185095;18669443;21750661;23658607;23965306;24129315;25428506;28011936;34428180;35820727", "class_list": "", "function": "DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice., [RefSeq, PubMed]; Identification of Crem, Crisp2 and Pot1a as the natural substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of specific exons in these genes., [RefSeq, PubMed]; RNA-binding protein, which may be required during spermatogenesis., [UniProtKB, UniProtKB, UniProtKB]; The translation of the two Dazap1 transcripts is differentially regulated during spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008266 poly(U) RNA binding;GO:0034046 poly(G) binding;GO:0035613 RNA stem-loop binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0001893 maternal placenta development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JII5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUN9-1", "uniprot_id": "DKK3_MOUSE", "mass": 38388.0, "length": 349, "protein_name": "Dickkopf-related protein 3", "gene_name": "Dkk3", "organism": "Mouse", "refseq_name": "dickkopf-related protein 3 isoform b precursor", "refseq_ac": "NP_056629", "gene_names_uniprotkb": "Dkk3", "gene_names_refseq": "Dkk3; dkk-3; mDkk-3", "protein_names_uniprotkb": "Dickkopf-related protein 3; Dickkopf-3; Dkk-3; mDkk-3", "protein_names_refseq": "dickkopf homolog 3; dickkopf-3; dickkopf-related protein 3 isoform b precursor; dickkopf-related protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:50781)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10495270;10570958;17143291;27550540;30899004;38285009;38682264", "class_list": "", "function": "Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)., [UniProtKB]; DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent manner., [RefSeq, PubMed]; Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway;GO:0030325 adrenal gland development;GO:0032348 negative regulation of aldosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9QUN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ41-1", "uniprot_id": "DBF4A_MOUSE", "mass": 74176.0, "length": 663, "protein_name": "Protein DBF4 homolog A", "gene_name": "Dbf4", "organism": "Mouse", "refseq_name": "protein DBF4 homolog A isoform 2", "refseq_ac": "NP_001177646", "gene_names_uniprotkb": "Dbf4; Dbf4a", "gene_names_refseq": "Ask; Dbf4", "protein_names_uniprotkb": "Protein DBF4 homolog A; MuDBF4", "protein_names_refseq": "activator of S phase kinase; protein DBF4 homolog A isoform 2; protein DBF4 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:27214); (R-MMU-176187); (R-MMU-68962)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10517317;12614612;21750661;31599954;34203471;35820727", "class_list": "", "function": "Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNS0;Q3TQP4;Q3V1K2;Q6NSQ1;Q9CXF2", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0031431 Dbf4-dependent protein kinase complex", "go_biological_process": "GO:0006260 DNA replication;GO:1901987 regulation of cell cycle phase transition;GO:0007089 traversing start control point of mitotic cell cycle;GO:0010571 positive regulation of nuclear cell cycle DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZ41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0P5-1", "uniprot_id": "DEST_MOUSE", "mass": 18522.0, "length": 165, "protein_name": "Destrin", "gene_name": "Dstn", "organism": "Mouse", "refseq_name": "destrin", "refseq_ac": "NP_062745", "gene_names_uniprotkb": "Dstn; Dsn; Sid23", "gene_names_refseq": "2610043P17Rik; ADF; Dsn; Dstn; corn1; sid23p", "protein_names_uniprotkb": "Destrin; ADF; Actin-depolymerizing factor; Sid 23", "protein_names_refseq": "actin-depolymerizing factor; corneal disease 1; destrin; sid 23", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:56431)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11809832;19131326;21540332;22645316;24788674;25153642;28135057;28528544;31219806;31599954;33300544;34428180;34559579;36288343;37453647;37507081", "class_list": "", "function": "Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner., [UniProtKB]; The actin depolymerizing factor destrin serves as a negative feedback inhibitor of smooth muscle cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0098794 postsynapse;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0048870 cell motility;GO:0051014 actin filament severing;GO:0030042 actin filament depolymerization;GO:0030043 actin filament fragmentation;GO:0030836 positive regulation of actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9R0P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTL0-1", "uniprot_id": "DEFB3_MOUSE", "mass": 7126.0, "length": 63, "protein_name": "Beta-defensin 3", "gene_name": "Defb3", "organism": "Mouse", "refseq_name": "beta-defensin 3 precursor", "refseq_ac": "NP_038784", "gene_names_uniprotkb": "Defb3; Bd3", "gene_names_refseq": "BD-3; Defb3", "protein_names_uniprotkb": "Beta-defensin 3; BD-3; Defensin, beta 3; mBD-3", "protein_names_refseq": "beta-defensin 3 precursor; beta-defensin 3", "tax_id": 10090, "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:27358); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10377137;10922379;29925780;37464450", "class_list": "", "function": "Alterations in fecal beta-defensin-3 secretion as a marker of instability of the gut microbiota., [RefSeq, PubMed]; Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa., [UniProtKB, PubMed]; MBD3 Is a novel inhibitor of both endogenous and exogenous potassium channels Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29R78", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUQ7-1", "uniprot_id": "DEXI_MOUSE", "mass": 10402.0, "length": 95, "protein_name": "Dexamethasone-induced protein", "gene_name": "Dexi", "organism": "Mouse", "refseq_name": "dexamethasone-induced protein", "refseq_ac": "NP_067403", "gene_names_uniprotkb": "Dexi; Myle", "gene_names_refseq": "1810029J14Rik; D16Bwg0586e; Dexi; Myle", "protein_names_uniprotkb": "Dexamethasone-induced protein; Protein MYLE", "protein_names_refseq": "dexamethasone-induced protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:58239)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11472984", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WUQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV68-1", "uniprot_id": "DECR2_MOUSE", "mass": 31300.0, "length": 292, "protein_name": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]", "gene_name": "Decr2", "organism": "Mouse", "refseq_name": "peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1", "refseq_ac": "NP_036063", "gene_names_uniprotkb": "Decr2; Pdcr", "gene_names_refseq": "Decr2", "protein_names_uniprotkb": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; 1.3.1.124; 2,4-dienoyl-CoA reductase 2", "protein_names_refseq": "2,4-dienoyl-CoA reductase 2; peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1; peroxisomal 2,4-dienoyl-CoA reductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:26378); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10464321;21750661;23576753;25428506;30084848;34428180;37453647", "class_list": "", "function": "Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.3.1.124;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8", "go_molecular_function": "GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009062 fatty acid catabolic process;GO:0006636 unsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WV68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01132-1", "uniprot_id": "EGF_MOUSE", "mass": 133072.0, "length": 1217, "protein_name": "Pro-epidermal growth factor", "gene_name": "Egf", "organism": "Mouse", "refseq_name": "pro-epidermal growth factor isoform 1 preproprotein", "refseq_ac": "NP_034243", "gene_names_uniprotkb": "Egf", "gene_names_refseq": "Egf", "protein_names_uniprotkb": "Pro-epidermal growth factor; EGF", "protein_names_refseq": "Pro-epidermal growth factor precursor (EGF); pro-epidermal growth factor isoform 1 preproprotein", "tax_id": 10090, "disease": "Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); primary hypomagnesemia (Disease Ontology:DOID:0060879); renal hypomagnesemia 4 (Disease Ontology:DOID:0060882); lupus nephritis (Disease Ontology:DOID:0080162); Alzheimer's disease (Disease Ontology:DOID:10652); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); gallbladder cancer (Disease Ontology:DOID:3121); oligodendroglioma (Disease Ontology:DOID:3181); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatitis (Disease Ontology:DOID:4989); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (mmu:13645); (R-MMU-114608); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-1963642); (R-MMU-212718); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8863795); (R-MMU-9009391); (R-MMU-9013507)", "pathway_count": 22, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10082370;1445923;1731873;21439629;21750661;31044023;31219806;37138025;37977137;38359610;4636327;4750422;6304537;6602382", "class_list": "", "function": "Aerobic Treadmill Exercise Upregulates Epidermal Growth Factor Levels and Improves Learning and Memory in d-galactose-Induced Aging in a Mouse Model., [RefSeq, PubMed]; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Potential therapeutic target of EGF on bile duct ligation model and biliary atresia children., [RefSeq, PubMed]; This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 22, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QNX6;Q569W5;Q6P9J2", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:1902966 positive regulation of protein localization to early endosome;GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0051223 regulation of protein transport;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P01132-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08545-1", "uniprot_id": "EFNA3_MOUSE", "mass": 25632.0, "length": 230, "protein_name": "Ephrin-A3", "gene_name": "Efna3", "organism": "Mouse", "refseq_name": "ephrin-A3 isoform a precursor", "refseq_ac": "NP_034238", "gene_names_uniprotkb": "Efna3; Epl3; Eplg3; Lerk3", "gene_names_refseq": "EFL-2; Efna3; Ehk1-L; Epl3; LERK-3", "protein_names_uniprotkb": "Ephrin-A3; EHK1 ligand; EHK1-L; EPH-related receptor tyrosine kinase ligand 3; LERK-3", "protein_names_refseq": "EHK1 ligand; EPH-related receptor tyrosine kinase ligand 3; ephrin-A3 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:13638); (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;27446912;30899004;34235739;37551686;8903354;9053851;9465306", "class_list": "", "function": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem., [RefSeq, PubMed]; Transcriptional regulation of the mouse EphA4, Ephrin-B2 and Ephrin-A3 genes by the circadian clock machinery., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O55217;Q08AV0", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0045664 regulation of neuron differentiation;GO:0016525 negative regulation of angiogenesis;GO:0007411 axon guidance;GO:1902993 positive regulation of amyloid precursor protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08545-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q7F5-1", "uniprot_id": "EDD13_MOUSE", "mass": 18665.0, "length": 164, "protein_name": "Epididymal protein 13", "gene_name": "Eddm13", "organism": "Mouse", "refseq_name": "epididymal protein 13 isoform 1 precursor", "refseq_ac": "NP_001170887", "gene_names_uniprotkb": "Eddm13; Epp13; Gm6792", "gene_names_refseq": "EG627821; Eddm13; Epp13; Gm6792", "protein_names_uniprotkb": "Epididymal protein 13", "protein_names_refseq": "epididymal protein 13 isoform 1 precursor; epididymis-specific protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:627821)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12920233;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q7F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08856-1", "uniprot_id": "ELL_MOUSE", "mass": 67146.0, "length": 602, "protein_name": "RNA polymerase II elongation factor ELL", "gene_name": "Ell", "organism": "Mouse", "refseq_name": "RNA polymerase II elongation factor ELL", "refseq_ac": "NP_031950", "gene_names_uniprotkb": "Ell", "gene_names_refseq": "Ell1; Ell; Men", "protein_names_uniprotkb": "RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein", "protein_names_refseq": "RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN); RNA polymerase II elongation factor ELL; eleven-nineteen lysine-rich leukemia protein", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:13716); (R-MMU-112382); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6807505); (R-MMU-75955)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "21750661;22195968;31219806;36210013;9037066", "class_list": "", "function": "Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (By similarity). Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXY9", "ec_number_list": "", "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0042795 snRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08856-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGF6-1", "uniprot_id": "ELMD2_MOUSE", "mass": 34747.0, "length": 293, "protein_name": "ELMO domain-containing protein 2", "gene_name": "Elmod2", "organism": "Mouse", "refseq_name": "ELMO domain-containing protein 2", "refseq_ac": "NP_001164162", "gene_names_uniprotkb": "Elmod2", "gene_names_refseq": "9830169G11Rik; Elmod2", "protein_names_uniprotkb": "ELMO domain-containing protein 2", "protein_names_refseq": "ELMO domain containing 2; ELMO domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244548)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;25428506;28324667;30084848;30779550;31219806;32614697;33596093;34428180;35820727", "class_list": "", "function": "Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family., [UniProtKB]; Elmod2 is the GTPase-activating protein essential to meiosis progression of mouse oocytes, most likely by regulating mitochondrial dynamics., [RefSeq, PubMed]; Roles for ELMOD2 and Rootletin in ciliogenesis., [RefSeq, PubMed]; The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXC7;Q8BHP5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0050688 regulation of defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BGF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35544-1", "uniprot_id": "EAA4_MOUSE", "mass": 60784.0, "length": 561, "protein_name": "Excitatory amino acid transporter 4", "gene_name": "Slc1a6", "organism": "Mouse", "refseq_name": "excitatory amino acid transporter 4 isoform 2", "refseq_ac": "NP_033226", "gene_names_uniprotkb": "Slc1a6; Eaat4", "gene_names_refseq": "EAAT4; Slc1a6", "protein_names_uniprotkb": "Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6", "protein_names_refseq": "excitatory amino acid transporter 4 isoform 2; excitatory amino acid transporter 4; high-affinity neuronal glutamate transporter; sodium-dependent glutamate/aspartate transporter; solute carrier family 1, member 6", "tax_id": 10090, "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:20513); (R-MMU-210500); (R-MMU-9958863)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12909286;12951653;21750661;25428506;29463856;29741614;30537735;34400517;9379843", "class_list": "", "function": "Abnormal expression of EAAT4, GABRA6, Spi2 combined with lower levels of glutamate and GABA are likely to be associated with the pathophysiology of Canavan disease., [RefSeq, PubMed]; Climbing Fiber-Mediated Spillover Transmission to Interneurons Is Regulated by EAAT4., [RefSeq, PubMed]; EAAT4 role in the spontaneous firing pattern and survival of Purkinje cells., [RefSeq, PubMed]; Overexpressed miR-128 downregulates the expression of AXIN1 but upregulates that of EAAT4 in dopamine neurons of Parkinson's disease mice., [RefSeq, PubMed]; Reduced Cerebellar EAAT4 Expression associated with loss of cerebellar Purkinje cells resluts in neurodegeneration and Niemann-Pick disease Type C1. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:9379843). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable)., [UniProtKB, UniProtKB, PubMed]; These results demonstrate that EAAT4 is expressed in astrocytes. This astrocytic localization of neuronal EAAT4 may reveal a new function of EAAT4 in the central nervous system., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0001504 neurotransmitter uptake;GO:0098712 L-glutamate import across plasma membrane;GO:0140009 L-aspartate import across plasma membrane;GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35544-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BL66-1", "uniprot_id": "EEA1_MOUSE", "mass": 160915.0, "length": 1411, "protein_name": "Early endosome antigen 1", "gene_name": "Eea1", "organism": "Mouse", "refseq_name": "early endosome antigen 1", "refseq_ac": "NP_001001932", "gene_names_uniprotkb": "Eea1", "gene_names_refseq": "A430109M19Rik; B230358H09Rik; Eea1; ZFYVE2", "protein_names_uniprotkb": "Early endosome antigen 1", "protein_names_refseq": "early endosome antigen 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:216238); (R-MMU-168138)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16138080;21750661;22460790;26495903;34428180;35820727;36288343", "class_list": "", "function": "Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DIC2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0005545 1-phosphatidylinositol binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0099565 chemical synaptic transmission, postsynaptic;GO:0006906 vesicle fusion;GO:0044788 host-mediated perturbation of viral process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BL66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54956-1", "uniprot_id": "DPOE2_MOUSE", "mass": 59387.0, "length": 527, "protein_name": "DNA polymerase epsilon subunit 2", "gene_name": "Pole2", "organism": "Mouse", "refseq_name": "DNA polymerase epsilon subunit 2", "refseq_ac": "NP_035263", "gene_names_uniprotkb": "Pole2", "gene_names_refseq": "Pole2", "protein_names_uniprotkb": "DNA polymerase epsilon subunit 2; DNA polymerase II subunit 2; DNA polymerase epsilon subunit B", "protein_names_refseq": "DNA polymerase II subunit 2; DNA polymerase epsilon small subunit; DNA polymerase epsilon subunit 2; DNA polymerase epsilon subunit B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18974); (R-MMU-110314); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-68952); (R-MMU-68962)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "11872158;21750661;25428506;31219806;34428180;9443964", "class_list": "", "function": "Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication., [UniProtKB, UniProtKB]; The second largest subunit of mouse DNA polymerase epsilon was found to interact with SAP18. The interaction induced repression of transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3Y7;Q8BP72", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0042276 error-prone translesion synthesis;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54956-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQM8-1", "uniprot_id": "EMAL5_MOUSE", "mass": 220106.0, "length": 1977, "protein_name": "Echinoderm microtubule-associated protein-like 5", "gene_name": "Eml5", "organism": "Mouse", "refseq_name": "echinoderm microtubule-associated protein-like 5", "refseq_ac": "NP_001074660", "gene_names_uniprotkb": "Eml5", "gene_names_refseq": "C130068M19Rik; Eml5", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 5; EMAP-5", "protein_names_refseq": "EMAP-5; echinoderm microtubule-associated protein-like 5", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:319670)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRL0;Q8R2W0", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BQM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89114-1", "uniprot_id": "DNJB5_MOUSE", "mass": 39119.0, "length": 348, "protein_name": "DnaJ homolog subfamily B member 5", "gene_name": "Dnajb5", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 5 isoform 3", "refseq_ac": "NP_001342369", "gene_names_uniprotkb": "Dnajb5; Hsc40", "gene_names_refseq": "1110058L06Rik; Dnajb5; Hsc40; Hsp40-3", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 5; Heat shock protein Hsp40-3; Heat shock protein cognate 40; Hsc40", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 5; dnaJ homolog subfamily B member 5 isoform 3; dnaJ homolog subfamily B member 5; heat shock protein cognate 40; heat shock protein hsp40-3", "tax_id": 10090, "disease": "congenital myopathy 21 (Disease Ontology:DOID:0081353); autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10570961;21750661;22645316", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006457 protein folding;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O89114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0I4-1", "uniprot_id": "EPC2_MOUSE", "mass": 90960.0, "length": 808, "protein_name": "Enhancer of polycomb homolog 2", "gene_name": "Epc2", "organism": "Mouse", "refseq_name": "enhancer of polycomb homolog 2", "refseq_ac": "NP_766251", "gene_names_uniprotkb": "Epc2", "gene_names_refseq": "5830499L14; D2Ertd694e; Epc2", "protein_names_uniprotkb": "Enhancer of polycomb homolog 2; EPC-like", "protein_names_refseq": "enhancer of polycomb homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227867)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;25605945;31219806;32848054;34428180;35822049;36852467;40885482", "class_list": "", "function": "May play a role in transcription or DNA repair., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AQU9;Q3URX9;Q80Y70;Q8BXC5", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0032777 piccolo histone acetyltransferase complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C0I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C2P3-1", "uniprot_id": "DUS1L_MOUSE", "mass": 53512.0, "length": 475, "protein_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like", "gene_name": "Dus1l", "organism": "Mouse", "refseq_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1", "refseq_ac": "NP_081100", "gene_names_uniprotkb": "Dus1l", "gene_names_refseq": "1110032N12Rik; Dus1l", "protein_names_uniprotkb": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; 1.3.1.88; tRNA-dihydrouridine synthase 1-like", "protein_names_refseq": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68730)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs. Affects the level of some mature tRNA and thereby the total cellular translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCN7;Q9D124", "ec_number_list": "1.3.1.88", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0102262 tRNA-dihydrouridine16 synthase activity;GO:0102263 tRNA-dihydrouridine17 synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002943 tRNA dihydrouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C2P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHI7-1", "uniprot_id": "ELOV5_MOUSE", "mass": 35332.0, "length": 299, "protein_name": "Very long chain fatty acid elongase 5", "gene_name": "Elovl5", "organism": "Mouse", "refseq_name": "very long chain fatty acid elongase 5", "refseq_ac": "NP_599016", "gene_names_uniprotkb": "Elovl5", "gene_names_refseq": "1110059L23Rik; Elovl5; HELO1", "protein_names_uniprotkb": "Very long chain fatty acid elongase 5; 2.3.1.199; 3-keto acyl-CoA synthase Elovl5; ELOVL FA elongase 5; ELOVL fatty acid elongase 5; Elongation of very long chain fatty acids protein 5; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl5; ELOVL FA elongase 5; ELOVL family member 5, elongation of long chain fatty acids; elongation of very long chain fatty acids protein 5; fatty acid elongase 1; homolog of yeast long chain polyunsaturated fatty acid elongation enzyme; very long chain 3-ketoacyl-CoA synthase 5; very long chain 3-oxoacyl-CoA synthase 5; very long chain fatty acid elongase 5", "tax_id": 10090, "disease": "spinocerebellar ataxia 38 (Disease Ontology:DOID:0050985)", "pathway": " (mmu:68801); (R-MMU-2046105); (R-MMU-2046106); (R-MMU-75876)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "17242355;18376007;18838740;20484733;20488798;21750661;24184513;25428506;30084848;34428180;36210013;37199746;38000296", "class_list": "glycogene", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (PubMed:24184513)., [UniProtKB, HAMAP, PubMed]; Deletion of Elovl5 leads to dyslipidemia and atherosclerosis in LDLR-deficient mice., [RefSeq, PubMed]; Elovl5-induced changes in hepatic fatty acid content affect multiple pathways regulating hepatic lipid and carbohydrate composition, [RefSeq, PubMed]; Reduced ELOVL5 activity leads to hepatic steatosis, and endogenously synthesized PUFAs are key regulators of SREBP-1c activation and fatty acid synthesis in liver, [RefSeq, PubMed]; Results establish a link between fatty acid elongation and hepatic glucose metabolism and suggest a role for regulators of Elovl5 activity in the treatment of diet-induced hyperglycemia., [RefSeq, PubMed]; Spinocerebellar ataxia 38: structure-function analysis shows ELOVL5 G230V is proteotoxic, conformationally altered and a mutational hotspot., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLG6;Q8BUE3;Q8R5D3", "ec_number_list": "2.3.1.48;2.3.1.-;2.3.1.199;1.14.11.68;2.1.1.364;2.7.11.22;2.7.11.23", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0097447 dendritic tree;GO:0005783 endoplasmic reticulum;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0045723 positive regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BHI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q56A04-1", "uniprot_id": "EME2_MOUSE", "mass": 41083.0, "length": 373, "protein_name": "Structure-specific endonuclease subunit EME2", "gene_name": "Eme2", "organism": "Mouse", "refseq_name": "structure-specific endonuclease subunit EME2", "refseq_ac": "NP_001156574", "gene_names_uniprotkb": "Eme2", "gene_names_refseq": "2810013J18Rik; Eme2", "protein_names_uniprotkb": "Structure-specific endonuclease subunit EME2", "protein_names_refseq": "essential meiotic endonuclease 1 homolog 2; probable crossover junction endonuclease EME2; structure-specific endonuclease subunit EME2", "tax_id": 10090, "disease": "", "pathway": " (mmu:193838); (R-MMU-5693568); (R-MMU-6783310)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;25428506;40885482", "class_list": "", "function": "Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME2 which is involved in the maintenance of genome stability. In the complex, EME2 is required for DNA cleavage, participating in DNA recognition and bending. MUS81-EME2 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0004520 DNA endonuclease activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0048476 Holliday junction resolvase complex;GO:0000781 chromosome, telomeric region;GO:1905347 endodeoxyribonuclease complex;GO:0005634 nucleus", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q56A04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48299-1", "uniprot_id": "EDN3_MOUSE", "mass": 23322.0, "length": 214, "protein_name": "Endothelin-3", "gene_name": "Edn3", "organism": "Mouse", "refseq_name": "endothelin-3 preproprotein", "refseq_ac": "NP_031929", "gene_names_uniprotkb": "Edn3", "gene_names_refseq": "ET-3; Edn3; PPET3; ls; tmgc48", "protein_names_uniprotkb": "Endothelin-3; ET-3; PPET3; Preproendothelin-3", "protein_names_refseq": "endothelin-3 preproprotein; preproendothelin-3", "tax_id": 10090, "disease": "Waardenburg syndrome type 4B (Disease Ontology:DOID:0110954); Hirschsprung's disease (Disease Ontology:DOID:10487); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (mmu:13616); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;30084848;39174539;8001160", "class_list": "", "function": "Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelins are endothelium-derived vasoconstrictor peptides., [UniProtKB, UniProtKB, UniProtKB]; This gene is a member of the endothelin family whose members encode proteins that act on G protein-coupled receptors. Endothelins are produced as large prepropolypeptide precursors that undergo a first cleavage by a subtilisin serine protease to form an inactive intermediate, which in turn is cleaved again by endothelin-converting enzyme 1 (ECE-1) to yield the active 21 amino acid peptide. This gene encodes a protein which is expressed in neural crest cells (NCC), binds to endothelin receptor b (Ednrb) and plays an essential role in the development of NCC-derived cell lineages including melanocytes and enteric neurons. Mutations in this gene are associated with terminal aganglionosis and white spotted coat in mice and Hirschsprung's disease and Waardenburg syndrome in humans. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q543L0", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0031708 endothelin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0043410 positive regulation of MAPK cascade;GO:0045987 positive regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48299-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78JN3-1", "uniprot_id": "ECI3_MOUSE", "mass": 35231.0, "length": 317, "protein_name": "Enoyl-CoA delta isomerase 3, peroxisomal", "gene_name": "Eci3", "organism": "Mouse", "refseq_name": "enoyl-CoA delta isomerase 3, peroxisomal isoform 1", "refseq_ac": "NP_081223", "gene_names_uniprotkb": "Eci3", "gene_names_refseq": "1810022C23Rik; Eci3; Kseg2", "protein_names_uniprotkb": "Enoyl-CoA delta isomerase 3, peroxisomal; 5.3.3.8; D3,D2-enoyl-CoA isomerase; Delta(3),delta(2)-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase", "protein_names_refseq": "D3,D2-enoyl-CoA isomerase; delta(3),delta(2)-enoyl-CoA isomerase; dodecenoyl-CoA isomerase; enoyl-CoA delta isomerase 3, peroxisomal isoform 1; enoyl-CoA delta isomerase 3, peroxisomal; kidney specific expressed protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69123)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;24344334;30084848", "class_list": "", "function": "Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA (PubMed:24344334). May also have activity towards other enoyl-CoA species (Probable)., [UniProtKB, PubMed]; Eci3 specifically evolved in rodents after gene duplication of Eci2 and is localized to the peroxisomes GeneRIF: Mouse Eci3 is almost exclusively expressed in kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3U0D8", "ec_number_list": "5.3.3.8;4.2.1.17;1.1.1.35", "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0009062 fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q78JN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SQM0-1", "uniprot_id": "EMAL6_MOUSE", "mass": 217941.0, "length": 1958, "protein_name": "Echinoderm microtubule-associated protein-like 6", "gene_name": "Eml6", "organism": "Mouse", "refseq_name": "echinoderm microtubule-associated protein-like 6", "refseq_ac": "NP_666128", "gene_names_uniprotkb": "Eml6; Eml5l", "gene_names_refseq": "2900083P10Rik; C230094A16Rik; EMAP-6; Eml6", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 6; EMAP-6; Echinoderm microtubule-associated protein-like 5-like", "protein_names_refseq": "echinoderm microtubule-associated protein-like 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:237711)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;35081682", "class_list": "", "function": "Microtubule-associated protein that plays an important role in the regulation of oocyte meiotic progression by maintaining spindle integrity and facilitating proper chromosome alignment., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4R3;Q8C7L3;Q8R1E3", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0005856 cytoskeleton", "go_biological_process": "GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SQM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZJ8-1", "uniprot_id": "EFC4A_MOUSE", "mass": 44438.0, "length": 394, "protein_name": "EF-hand calcium-binding domain-containing protein 4A", "gene_name": "Cracr2b", "organism": "Mouse", "refseq_name": "EF-hand calcium-binding domain-containing protein 4A", "refseq_ac": "NP_001020274", "gene_names_uniprotkb": "Cracr2b; Efcab4a", "gene_names_refseq": "6330520A15Rik; Cracr2a; Cracr2b; Efcab4a; Efcab4", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 4A; Calcium release-activated channel regulator 2B", "protein_names_refseq": "EF-hand calcium binding domain 4A; EF-hand calcium-binding domain-containing protein 4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:213573)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in store-operated Ca(2+) entry (SOCE)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMV3;Q8R0L0", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80ZJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08543-1", "uniprot_id": "EFNA5_MOUSE", "mass": 26339.0, "length": 228, "protein_name": "Ephrin-A5", "gene_name": "Efna5", "organism": "Mouse", "refseq_name": "ephrin-A5 isoform 2 precursor", "refseq_ac": "NP_034239", "gene_names_uniprotkb": "Efna5; Epl7; Eplg7; Lerk7", "gene_names_refseq": "AL-1; EFL-5; Efna5; Ephrin-A5; Epl7; LERK-7; RAGS", "protein_names_uniprotkb": "Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7", "protein_names_refseq": "EPH-related receptor tyrosine kinase ligand 7; ephrin-A5 isoform 2 precursor", "tax_id": 10090, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (mmu:13640); (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11089974;15107857;17448994;18948590;19656770;27446912;30899004;8903354;9053851", "class_list": "", "function": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08544", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity;GO:0005169 neurotrophin TRKB receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009897 external side of plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08543-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35290-1", "uniprot_id": "ECP3_MOUSE", "mass": 17745.0, "length": 156, "protein_name": "Eosinophil cationic-type ribonuclease 3", "gene_name": "Ear3", "organism": "Mouse", "refseq_name": "eosinophil cationic-type ribonuclease 3 precursor", "refseq_ac": "NP_059084", "gene_names_uniprotkb": "Ear3; Rnase3", "gene_names_refseq": "Ear3; Rnase3; mR3", "protein_names_uniprotkb": "Eosinophil cationic-type ribonuclease 3; MR-3", "protein_names_refseq": "MR-3; eosinophil cationic-type ribonuclease 3 precursor; eosinophil cationic-type ribonuclease 3; eosinophil-associated ribonuclease 3; murine ribonuclease 3; ribonuclease, RNase A family 3", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156)", "pathway": " (mmu:53876)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26495903;27802388;36852467;9336452", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35290-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35474-1", "uniprot_id": "EDIL3_MOUSE", "mass": 53712.0, "length": 480, "protein_name": "EGF-like repeat and discoidin I-like domain-containing protein 3", "gene_name": "Edil3", "organism": "Mouse", "refseq_name": "EGF-like repeat and discoidin I-like domain-containing protein 3 isoform a precursor", "refseq_ac": "NP_001033076", "gene_names_uniprotkb": "Edil3; Del1", "gene_names_refseq": "Del-1; Del1; Edil3; Sox2-cre; Sox2Cre; Tg(Sox2-cre)1Amc", "protein_names_uniprotkb": "EGF-like repeat and discoidin I-like domain-containing protein 3; Developmentally-regulated endothelial cell locus 1 protein; Integrin-binding protein DEL1", "protein_names_refseq": "EGF-like repeat and discoidin I-like domain-containing protein 3 isoform a precursor; EGF-like repeat and discoidin I-like domain-containing protein 3; developmental endothelial locus-1; developmentally-regulated endothelial cell locus 1 protein; integrin-binding protein DEL1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13612)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11959660;12074641;25428506;9420328", "class_list": "", "function": "Acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis, [RefSeq, PubMed]; Mediates vascular smooth muscle cells adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3), [RefSeq, PubMed]; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35475;Q8CBF7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007155 cell adhesion;GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35474-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35949-1", "uniprot_id": "ELOV3_MOUSE", "mass": 32060.0, "length": 271, "protein_name": "Very long chain fatty acid elongase 3", "gene_name": "Elovl3", "organism": "Mouse", "refseq_name": "very long chain fatty acid elongase 3 isoform 1", "refseq_ac": "NP_031729", "gene_names_uniprotkb": "Elovl3; Cig30", "gene_names_refseq": "CIN-2; Cig30; Elovl3", "protein_names_uniprotkb": "Very long chain fatty acid elongase 3; 2.3.1.199; 3-keto acyl-CoA synthase Elovl3; CIN-2; Cold-inducible glycoprotein of 30 kDa; ELOVL FA elongase 3; ELOVL fatty acid elongase 3; Elongation of very long chain fatty acids protein 3; Very long chain 3-ketoacyl-CoA synthase 3; Very long chain 3-oxoacyl-CoA synthase 3", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl3; ELOVL FA elongase 3; cold inducible glycoprotein 30; cold-inducible glycoprotein of 30 kDa; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3; elongation of very long chain fatty acids protein 3; elongation of very long chain fatty acids-like 3; very long chain 3-ketoacyl-CoA synthase 3; very long chain 3-oxoacyl-CoA synthase 3; very long chain fatty acid elongase 3 isoform 1; very long chain fatty acid elongase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12686); (R-MMU-2046105); (R-MMU-2046106); (R-MMU-75876)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10429212;10473596;10791983;14581464;16326704;20605947;21750661;34428180;37030067;37726091;37847682;9395518", "class_list": "glycogene", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Participates in the formation of certain VLCFA and triglycerides in certain cells of the hair follicles and the sebaceous glands, required for skin barrier function. Critical enzyme for lipid accumulation and metabolic activity in brown adipocytes during the early phase of the tissue recruitment. Plays a role in lipid storage and in resistance to diet-induced obesity., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, PubMed]; Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression., [RefSeq, PubMed]; Hepatic ELOVL3 is dispensable for lipid metabolism in mice., [RefSeq, PubMed]; Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O35949-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70585-1", "uniprot_id": "DTNB_MOUSE", "mass": 74399.0, "length": 659, "protein_name": "Dystrobrevin beta", "gene_name": "Dtnb", "organism": "Mouse", "refseq_name": "dystrobrevin beta isoform a", "refseq_ac": "NP_001155937", "gene_names_uniprotkb": "Dtnb", "gene_names_refseq": "Dtnb", "protein_names_uniprotkb": "Dystrobrevin beta; Beta-dystrobrevin; DTN-B; mDTN-BDTN-B", "protein_names_refseq": "DTN-B; beta-dystrobrevin; dystrobrevin beta isoform a; mDTN-BDTN-B; mDTN-B", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:13528); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10545507;10893187;11316798;11585924;14600269;16540561;17265465;17610895;20530487;21750661;22978324;34418053;36210013;9419360;9540997;9799833", "class_list": "", "function": "Beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35, [RefSeq, PubMed]; Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (PubMed:11585924). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:20530487). May be required for proper maturation and function of a subset of inhibitory synapses (PubMed:16540561)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q0F2;O70563;Q9CTZ1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0030182 neuron differentiation;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O70585-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08152-1", "uniprot_id": "EGR2_MOUSE", "mass": 49819.0, "length": 470, "protein_name": "E3 SUMO-protein ligase EGR2", "gene_name": "Egr2", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase EGR2 isoform 2", "refseq_ac": "NP_001334387", "gene_names_uniprotkb": "Egr2; Egr-2; Krox-20; Zfp-25", "gene_names_refseq": "Egr-2; Egr2; Krox-20; Krox20; NGF1-B; Zfp-25; Zfp-6", "protein_names_uniprotkb": "E3 SUMO-protein ligase EGR2; 2.3.2.-; E3 SUMO-protein transferase ERG2; EGR-2; Early growth response protein 2; Zinc finger protein Krox-20", "protein_names_refseq": "E3 SUMO-protein ligase EGR2 isoform 2; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; early growth response protein 2; zinc finger protein Krox-20", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); Charcot-Marie-Tooth disease type 1D (Disease Ontology:DOID:0110150); congenital hypomyelinating neuropathy 1 (Disease Ontology:DOID:0110195); motor peripheral neuropathy (Disease Ontology:DOID:2477); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:13654); (R-MMU-9031628)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10068633;11509834;11823429;1598206;16054051;1674431;17938205;19651900;1969796;21750661;2452975;2496302;25428506;28576496;3129290;31852952;32736174;34428180;40499546;7935840;8093858", "class_list": "", "function": "E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sequence-specific DNA-binding transcription factor (PubMed:11823429, PubMed:1674431, PubMed:1969796, PubMed:31852952). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (PubMed:11823429, PubMed:1674431, PubMed:1969796, PubMed:31852952, PubMed:8093858). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (PubMed:11823429). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (PubMed:17938205, PubMed:1969796, PubMed:8093858). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (PubMed:11823429, PubMed:1674431). Promotes the expression of HOXB3 in the rhombomere r5 and of HOXB3 in r3 and r5 in the hindbrain (PubMed:11823429, PubMed:8093858). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (PubMed:10068633, PubMed:7935840). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (PubMed:11509834). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (PubMed:16054051)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.68;2.3.2.-;3.1.13.-;2.7.7.48;2.7.7.6;2.1.1.364;3.6.4.-", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0021569 rhombomere 3 development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P08152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21550-1", "uniprot_id": "ENOB_MOUSE", "mass": 47025.0, "length": 434, "protein_name": "Beta-enolase", "gene_name": "Eno3", "organism": "Mouse", "refseq_name": "beta-enolase", "refseq_ac": "NP_001129534", "gene_names_uniprotkb": "Eno3; Eno-3", "gene_names_refseq": "Eno-3; Eno3; MSE", "protein_names_uniprotkb": "Beta-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 3; MSE; Muscle-specific enolase; Skeletal muscle enolase", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; beta-enolase; muscle-specific enolase; skeletal muscle enolase", "tax_id": 10090, "disease": "aortic valve stenosis (Disease Ontology:DOID:1712)", "pathway": " (mmu:13808); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10848992;11229603;1339335;1525038;21183079;21750661;23446454;2734297;31201144;31219806;33725478;36288343;37507081;39927985;8594891;9169614", "class_list": "", "function": "Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Appears to have a function in striated muscle development and regeneration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The in vitro evidence revealed that statins increased the expression of muscle specific glycolytic enzyme b-enolase through promoting the degradation of basal p53 proteins, resulting in increased of lactate production... Elevated lactate production by statins through the p53/b-enolase axis contributes to Statin-associated muscle symptoms (SAMS), [RefSeq, PubMed]; This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0000015 phosphopyruvate hydratase complex", "go_biological_process": "GO:0006096 glycolytic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P21550-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36368-1", "uniprot_id": "EGFB2_MOUSE", "mass": 28689.0, "length": 261, "protein_name": "Epidermal growth factor-binding protein type B", "gene_name": "Egfbp2", "organism": "Mouse", "refseq_name": "epidermal growth factor-binding protein type B preproprotein", "refseq_ac": "NP_034245", "gene_names_uniprotkb": "Egfbp2; Egfbp-2; Klk-13; Klk13", "gene_names_refseq": "Egfbp-2; Egfbp2; Klk1b26; PRECE-1; mGk-13", "protein_names_uniprotkb": "Epidermal growth factor-binding protein type B; 3.4.21.119; EGF-BP B; Glandular kallikrein K13; PRECE-1; Prorenin-converting enzyme 1; Tissue kallikrein 13; mGK-13", "protein_names_refseq": "EGF-BP B; epidermal growth factor-binding protein type B preproprotein; glandular kallikrein K13; kallikrein 1b26; prorenin-converting enzyme 1; tissue kallikrein 13", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:13647)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15545270;1918045;3036794;3322387;9232643", "class_list": "", "function": "Cleaves REN2 at a dibasic site to yield mature renin., [UniProtKB]; Klk-13 acts as an autoantigen and may increase T cells responsive to organs commonly expressing Klk-13, playing a pivotal role in the etiology of progression of disease in IQI/Jic mice, [RefSeq, PubMed]; The protein encoded by this gene belongs to the kallikrein family, which is a highly homologous group of serine proteases encoded by a cluster of related genes on chromosome 7. This gene has been shown to function as both a prorenin converting enzyme and as epidermal growth factor (EGF)-binding protein involved in the maturation of EGF (PMIDs: 1918045, 3322387, 9685728). This gene is thought to be distinct from Klk1b26 gene (GeneID:16618), with which it shares 98% identity (PMID:1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. Blast analyses suggest that this gene is missing from the current reference (GRCm38, based on C57BL/6J genome) and alternate Celera (based on mixed strain genomes) assemblies. Therefore, the RefSeq for this locus was based on sequence from the ICR strain, which has been reported in literature (PMID:1959648) to contain both genes. [provided by RefSeq, Aug 2012]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P00754", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47801-1", "uniprot_id": "EMP1_MOUSE", "mass": 17813.0, "length": 160, "protein_name": "Epithelial membrane protein 1", "gene_name": "Emp1", "organism": "Mouse", "refseq_name": "epithelial membrane protein 1 isoform a", "refseq_ac": "NP_001275556", "gene_names_uniprotkb": "Emp1; Tmp", "gene_names_refseq": "Emp1; I-8-09; TMP", "protein_names_uniprotkb": "Epithelial membrane protein 1; EMP-1; Tumor-associated membrane protein", "protein_names_refseq": "EMP-1; epithelial membrane protein 1 isoform a; tumor-associated membrane protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13730)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19656770;21750661;28011936;36352230;8884260;8996089", "class_list": "", "function": "Metastatic recurrence in colorectal cancer arises from residual EMP1[+] cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0032060 bleb assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47801-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48302-1", "uniprot_id": "EDNRB_MOUSE", "mass": 49561.0, "length": 442, "protein_name": "Endothelin receptor type B", "gene_name": "Ednrb", "organism": "Mouse", "refseq_name": "endothelin receptor type B isoform 1 precursor", "refseq_ac": "NP_001129533", "gene_names_uniprotkb": "Ednrb", "gene_names_refseq": "ET-BR; ET-B; ETR-b; ETb; Ednrb; Sox10m1", "protein_names_uniprotkb": "Endothelin receptor type B; ET-BR; ET-B; Endothelin receptor non-selective type", "protein_names_refseq": "endothelin B receptor; endothelin receptor non-selective type; endothelin receptor type B isoform 1 precursor; piebald", "tax_id": 10090, "disease": "ABCD syndrome (Disease Ontology:DOID:0050600); Waardenburg syndrome type 4A (Disease Ontology:DOID:0110953); sensorineural hearing loss (Disease Ontology:DOID:10003); Hirschsprung's disease (Disease Ontology:DOID:10487); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); megacolon (Disease Ontology:DOID:11372); asthma (Disease Ontology:DOID:2841); myocardial infarction (Disease Ontology:DOID:5844); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); hepatopulmonary syndrome (Disease Ontology:DOID:900); Waardenburg syndrome (Disease Ontology:DOID:9258); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:13618); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;30084848;31219806;34428180;8001159", "class_list": "", "function": "Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages., [UniProtKB]; This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q542M3", "ec_number_list": "", "go_molecular_function": "GO:0004962 endothelin receptor activity;GO:0017046 peptide hormone binding;GO:0031702 type 1 angiotensin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007497 posterior midgut development;GO:0014043 negative regulation of neuron maturation;GO:0031620 regulation of fever generation;GO:0035645 enteric smooth muscle cell differentiation;GO:0048484 enteric nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P48302-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52795-1", "uniprot_id": "EFNB1_MOUSE", "mass": 37859.0, "length": 345, "protein_name": "Ephrin-B1", "gene_name": "Efnb1", "organism": "Mouse", "refseq_name": "ephrin-B1 precursor", "refseq_ac": "NP_034240", "gene_names_uniprotkb": "Efnb1; Epl2; Eplg2; Lerk2; Stra1", "gene_names_refseq": "Cek5-L; EFL-3; Efnb1; Elk-L; Epl2; Eplg2; LERK-2; Lerk2; Stra1", "protein_names_uniprotkb": "Ephrin-B1; CEK5 receptor ligand; CEK5-L; EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; Stimulated by retinoic acid gene 1 protein", "protein_names_refseq": "CEK5 receptor ligand; Cek ligand; ELK ligand; EPH-related receptor tyrosine kinase ligand 2; ephrin-B1 precursor; stimulated by retinoic acid gene 1 protein", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); craniofrontonasal syndrome (Disease Ontology:DOID:14737); dysostosis (Disease Ontology:DOID:1934)", "pathway": " (mmu:13641); (R-MMU-2682334); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10197531;10704386;17114649;19515908;21429299;27446912;36649053;39437409;7649373;7896266;7929389", "class_list": "", "function": "Astrocytic Ephrin-B1 Regulates Oligodendrocyte Development and Myelination., [RefSeq, PubMed]; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:10704386, PubMed:7929389). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:10704386, PubMed:7929389). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (By similarity). Can also bind EPHB2 and EPHB3 (PubMed:7929389). Binds to, and induces the collapse of, commissural axons/growth cones in vitro (PubMed:10704386). May play a role in constraining the orientation of longitudinally projecting axons (PubMed:10704386)., [UniProtKB, UniProtKB, PubMed, PubMed]; Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a membrane protein that acts as a ligand for Eph family receptors. Signalling occurs bidirectionally in both the cell containing the receptor and the cell expressing this protein. Activity of this protein is important in neuronal axon growth and other developmental processes. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0099054 presynapse assembly;GO:0007399 nervous system development;GO:0048013 ephrin receptor signaling pathway;GO:0031295 T cell costimulation;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P52795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07139-1", "uniprot_id": "ECT2_MOUSE", "mass": 103131.0, "length": 913, "protein_name": "Protein ECT2", "gene_name": "Ect2", "organism": "Mouse", "refseq_name": "protein ECT2 isoform 2", "refseq_ac": "NP_001171096", "gene_names_uniprotkb": "Ect2; mKIAA4037", "gene_names_refseq": "Ect2", "protein_names_uniprotkb": "Protein ECT2; Epithelial cell-transforming sequence 2 oncogene", "protein_names_refseq": "ect2 oncogene; epithelial cell-transforming sequence 2 oncogene; protein ECT2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13605); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "14645260;17904126;21183079;21350944;21750661;34428180;8464478", "class_list": "", "function": "ECT2 has a role in activating the Rho signaling pathways leading to malignant transformation, [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZP2;Q5DTR8;Q80VE4;Q8CIH2;Q8K2A0;Q8R3E2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0007399 nervous system development;GO:0015031 protein transport;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q07139-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UP87-1", "uniprot_id": "ELNE_MOUSE", "mass": 28648.0, "length": 265, "protein_name": "Neutrophil elastase", "gene_name": "Elane", "organism": "Mouse", "refseq_name": "neutrophil elastase precursor", "refseq_ac": "NP_056594", "gene_names_uniprotkb": "Elane; Ela2", "gene_names_refseq": "Ela2; Elane; F430011M15Rik; NE", "protein_names_uniprotkb": "Neutrophil elastase; 3.4.21.37; Elastase-2; Leukocyte elastase", "protein_names_refseq": "elastase 2, neutrophil; leukocyte elastase; neutrophil elastase precursor", "tax_id": 10090, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); mucositis (Disease Ontology:DOID:0080178); COVID-19 (Disease Ontology:DOID:0080600); severe congenital neutropenia 1 (Disease Ontology:DOID:0080625); pleurisy (Disease Ontology:DOID:10247); disseminated intravascular coagulation (Disease Ontology:DOID:11247); toxic shock syndrome (Disease Ontology:DOID:14115); essential thrombocythemia (Disease Ontology:DOID:2224); transient cerebral ischemia (Disease Ontology:DOID:224); suppurative periapical periodontitis (Disease Ontology:DOID:2562); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); cyclic hematopoiesis (Disease Ontology:DOID:5339); periodontitis (Disease Ontology:DOID:824); polycythemia vera (Disease Ontology:DOID:8997); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:50701); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-5620971); (R-MMU-6798695); (R-MMU-6803157); (R-MMU-977606)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10947984;20676107;20974816;30084848;32045782;39627609;8035830", "class_list": "", "function": "Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes (PubMed:10947984). Shows microbicidal activity in neutrophils by mediating cleavage and degradation of bacterial proteins (By similarity). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). Involved for the formation of neutrophil extracellular traps (NETs): translocates into the nucleus downstream of MPO and mediates degadation of histone H4, thereby participating to chromatin decondensation (PubMed:20974816, PubMed:32045782). NETs are mainly composed of DNA fibers and are released by neutrophils to trap pathogens during inflammation (By similarity). Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (By similarity). Promotes blood coagulation (PubMed:20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (By similarity). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the chymotrypsin-like family of serine protease enzymes that hydrolyzes a broad range of protein substrates including elastin. This gene is expressed by neutrophils where the encoded enzyme is stored in azurophil granules. Upon neutrophil activation, the active enzyme is released into the extracellular mileu. Mice lacking the encoded protein exhibit increased susceptibility to sepsis and death following intraperitoneal infection with Gram negative bacteria. This gene is located adjacent to a related proteinase gene on chromosome 10. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H698;Q61515", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.18;3.4.24.22;3.4.24.34;3.4.21.4;3.4.21.-;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.4.23.5;3.4.21.5;3.2.1.52;3.4.21.39;3.4.21.59;3.2.1.23;3.4.21.34;3.4.21.20;3.4.24.17;2.7.10.2;2.7.11.13;3.1.3.48;3.4.24.24;3.4.24.65;3.4.24.35;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.24.23;3.6.5.2;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.2.1.166;3.1.6.14;3.1.3.16;1.8.3.2;5.3.99.3;6.3.4.21;2.4.1.1;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;2.3.2.5;3.1.21.-;3.2.1.14;1.6.2.2;3.4.24.7;3.4.14.2;3.5.1.3;3.4.18.1;3.4.19.9", "go_molecular_function": "GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0009986 cell surface", "go_biological_process": "GO:0002812 biosynthetic process of antibacterial peptides active against Gram-negative bacteria;GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0070947 neutrophil-mediated killing of fungus;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UP87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V124-1", "uniprot_id": "EID3_MOUSE", "mass": 43308.0, "length": 375, "protein_name": "EP300-interacting inhibitor of differentiation 3", "gene_name": "Eid3", "organism": "Mouse", "refseq_name": "EP300-interacting inhibitor of differentiation 3", "refseq_ac": "NP_079775", "gene_names_uniprotkb": "Eid3", "gene_names_refseq": "1700027M21Rik; Eid3; NS4EB", "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; NS4EB; Non-SMC element 4 homolog B; Non-structural maintenance of chromosomes element 4 homolog B", "protein_names_refseq": "EID-1-like inhibitor of differentiation 3; EP300-interacting inhibitor of differentiation 3; non-SMC element 4 homolog B; non-structural maintenance of chromosomes element 4 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66341); (R-MMU-3108214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15970276;21364888;34428180;39927985", "class_list": "", "function": "Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors (By similarity)., [UniProtKB]; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTL4;Q4KL03;Q8CF34;Q9CVN8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V124-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V188-1", "uniprot_id": "ENDOU_MOUSE", "mass": 47010.0, "length": 412, "protein_name": "Uridylate-specific endoribonuclease", "gene_name": "Endou", "organism": "Mouse", "refseq_name": "uridylate-specific endoribonuclease isoform 2 precursor", "refseq_ac": "NP_001162164", "gene_names_uniprotkb": "Endou; Pp11r", "gene_names_refseq": "Endou; Pp11r; Tcl-30", "protein_names_uniprotkb": "Uridylate-specific endoribonuclease; 3.1.-.-; 4.6.1.-; PP11-related protein; Placental protein 11-related protein; Protein endoU; T-cell-specific protein 30; Tcl-30", "protein_names_refseq": "PP11-related protein; T-cell-specific protein 30; placental protein 11 related; placental protein 11-related protein; poly(U)-specific endoribonuclease; protein endoU; uridylate-specific endoribonuclease isoform 2 precursor; uridylate-specific endoribonuclease", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19011)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1506680;21750661;24344237;8104059", "class_list": "", "function": "EndoU is a critical regulator of an RNA-dependent pathway controlling peripheral B cell survival and antigen responsiveness that may contribute to peripheral B cell tolerance., [RefSeq, PubMed]; Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites. Targets mRNAs to regulate their expression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q01084", "ec_number_list": "3.1.-.-;4.6.1.-", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0003723 RNA binding;GO:0005044 scavenger receptor activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0006955 immune response;GO:0050995 negative regulation of lipid catabolic process;GO:0007565 female pregnancy;GO:0016441 post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3V188-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4PZA2-1", "uniprot_id": "ECE1_MOUSE", "mass": 87073.0, "length": 769, "protein_name": "Endothelin-converting enzyme 1", "gene_name": "Ece1", "organism": "Mouse", "refseq_name": "endothelin-converting enzyme 1 isoform c", "refseq_ac": "NP_955011", "gene_names_uniprotkb": "Ece1", "gene_names_refseq": "ECE-1a; ECE-1b; ECE-1c1; ECE-1d; ECE-1; Ece1", "protein_names_uniprotkb": "Endothelin-converting enzyme 1; 3.4.24.71; ECE-1", "protein_names_refseq": "endothelin-converting enzyme 1 isoform c; endothelin-converting enzyme-1a; endothelin-converting enzyme-1b; endothelin-converting enzyme-1c1; endothelin-converting enzyme-1d", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); nephrotic syndrome (Disease Ontology:DOID:1184); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); double outlet right ventricle (Disease Ontology:DOID:6406); pulmonary hypertension (Disease Ontology:DOID:6432); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:230857); (R-MMU-375276)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;16540265;19349973;19656770;21750661;22872234;25428506;26495903;26740625;28011936;30084848;30899004;31219806;32768584;34203471;34428180;35984892;36210013;37828378;37897251", "class_list": "", "function": "A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)., [RefSeq, PubMed]; Converts big endothelin-1 to endothelin-1., [UniProtKB, UniProtKB, UniProtKB]; Endothelin converting enzyme-1 (ECE-1) deletion in association with Endothelin-1 downregulation ameliorates kidney fibrosis in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 13, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "B1AXF9;Q4PZ99;Q4PZA1;Q6P9Q9", "ec_number_list": "3.4.24.71", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007507 heart development;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0031175 neuron projection development;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q4PZA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q58FA4-1", "uniprot_id": "E2F8_MOUSE", "mass": 93276.0, "length": 860, "protein_name": "Transcription factor E2F8", "gene_name": "E2f8", "organism": "Mouse", "refseq_name": "transcription factor E2F8", "refseq_ac": "NP_001013386", "gene_names_uniprotkb": "E2f8", "gene_names_refseq": "4432406C08Rik; E2f8", "protein_names_uniprotkb": "Transcription factor E2F8; E2F-8", "protein_names_refseq": "E2f family member 8; transcription factor E2F8", "tax_id": 10090, "disease": "", "pathway": " (mmu:108961); (R-MMU-6804116)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15722552;16179649;18194653;21183079;22516201;22903062;23064264;23064266;25428506;30084848;36241625;37326141", "class_list": "", "function": "ADP Ribosylation Factor 6 Relieves Airway Inflammation and Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal Transition in Experimental Asthma, Possibly by Regulating of E2F Transcription Factor 8., [RefSeq, PubMed]; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; E2F8 may have an important role in repressing the expression of E2F-target genes in the S-phase of the cell cycle. Publication Status: Online-Only, [RefSeq, PubMed]; Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4W2;Q497V7;Q5PRE4;Q8BQJ5;Q8C3Y5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0033301 cell cycle comprising mitosis without cytokinesis;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q58FA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BU09-1", "uniprot_id": "EAPP_MOUSE", "mass": 32494.0, "length": 281, "protein_name": "E2F-associated phosphoprotein", "gene_name": "Eapp", "organism": "Mouse", "refseq_name": "E2F-associated phosphoprotein isoform 2", "refseq_ac": "NP_001318091", "gene_names_uniprotkb": "Eapp", "gene_names_refseq": "1810011O16Rik; Eapp", "protein_names_uniprotkb": "E2F-associated phosphoprotein; EAPP", "protein_names_refseq": "E2F-associated phosphoprotein isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66266)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15716352;21183079;21750661;25704466;26802973;28315936;34428180", "class_list": "", "function": "Data provide strong evidence that the cis-modulated gene, Eapp, is associated with stress responses, and that validated downstream targets and members of Eapp gene network may also be involved in the development of stress., [RefSeq, PubMed]; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity)., [UniProtKB]; Studies have shown that EAPP expression changes after spinal cord injury, suggesting that EAPP might participate in regulating biochemical and physiological responses following this type of injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZB5;Q9D914", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0034244 negative regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5BU09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60900-1", "uniprot_id": "ELAV3_MOUSE", "mass": 39533.0, "length": 367, "protein_name": "ELAV-like protein 3", "gene_name": "Elavl3", "organism": "Mouse", "refseq_name": "ELAV-like protein 3", "refseq_ac": "NP_034617", "gene_names_uniprotkb": "Elavl3; Huc", "gene_names_refseq": "2600009P04Rik; Elavl3; Huc; PLE21; mHuC", "protein_names_uniprotkb": "ELAV-like protein 3; Hu-antigen C; HuC", "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); ELAV-like protein 3; HU-antigen C", "tax_id": 10090, "disease": "", "pathway": " (mmu:15571)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10734193;11573004;21288476;21750661;9016658", "class_list": "", "function": "RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10734193, PubMed:9016658). May also bind poly-A tracts via RRM 3 (PubMed:9016658). May be involved in neuronal differentiation and maintenance (PubMed:9016658). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (PubMed:11573004)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60901", "ec_number_list": "", "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0140517 protein-RNA adaptor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61614-1", "uniprot_id": "EDNRA_MOUSE", "mass": 48578.0, "length": 427, "protein_name": "Endothelin-1 receptor", "gene_name": "Ednra", "organism": "Mouse", "refseq_name": "endothelin-1 receptor precursor", "refseq_ac": "NP_034462", "gene_names_uniprotkb": "Ednra; Gpcr10", "gene_names_refseq": "AEA001; ET-AR; ETa; Ednra; Gpcr10; Mhdaaea1", "protein_names_uniprotkb": "Endothelin-1 receptor; ET-AR; ET-A; Endothelin receptor type A", "protein_names_refseq": "ET-A; G-protein coupled receptor 10; endothelin A receptor; endothelin-1 receptor precursor; endothelin-1 receptor", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); mandibulofacial dysostosis with alopecia (Disease Ontology:DOID:0060365); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); nephrotic syndrome (Disease Ontology:DOID:1184); velocardiofacial syndrome (Disease Ontology:DOID:12583); impotence (Disease Ontology:DOID:1875); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:13617); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;34428180;36637912;8288218", "class_list": "", "function": "Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O54993;Q91VV2", "ec_number_list": "", "go_molecular_function": "GO:0004962 endothelin receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0030315 T-tubule", "go_biological_process": "GO:0030878 thyroid gland development;GO:1904888 cranial skeletal system development;GO:0048484 enteric nervous system development;GO:0050678 regulation of epithelial cell proliferation;GO:0086100 endothelin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61614-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAL1-1", "uniprot_id": "DRAXI_MOUSE", "mass": 38363.0, "length": 343, "protein_name": "Draxin", "gene_name": "Draxin", "organism": "Mouse", "refseq_name": "draxin precursor", "refseq_ac": "NP_081702", "gene_names_uniprotkb": "Draxin", "gene_names_refseq": "2610109H07Rik; Draxin; neucrin", "protein_names_uniprotkb": "Draxin; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neucrin", "protein_names_refseq": "dorsal repulsive axon guidance protein; draxin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:70433)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19150847;19808066;19857465;20621059;23206892;33945466", "class_list": "", "function": "Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway., [UniProtKB, HAMAP, PubMed, PubMed]; DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation. Publication Status: Online-Only, [RefSeq, PubMed]; Draxin knockout mice showed defasciculation of spinal cord commissural axons & absence of all forebrain commissures; draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord & forebrain commissures, [RefSeq, PubMed]; Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues., [RefSeq, PubMed]; These results suggest that draxin functions as an inhibitory guidance cue for olfactory bulb axons and indicate its contribution to the formation of the lateral olfactory tract., [RefSeq, PubMed]; This study found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A7G4;B2KFL9;Q8C3D8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0030900 forebrain development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010977 negative regulation of neuron projection development;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PAL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNG5-1", "uniprot_id": "EMAL2_MOUSE", "mass": 70734.0, "length": 649, "protein_name": "Echinoderm microtubule-associated protein-like 2", "gene_name": "Eml2", "organism": "Mouse", "refseq_name": "echinoderm microtubule-associated protein-like 2 isoform 2", "refseq_ac": "NP_001156468", "gene_names_uniprotkb": "Eml2", "gene_names_refseq": "1600029N02Rik; EMAP-2; Eml2", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 2; EMAP-2", "protein_names_refseq": "echinoderm microtubule-associated protein-like 2 isoform 2", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:72205)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;26740625;31219806;34428180;35820727;37507081", "class_list": "", "function": "Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QK48;Q9DAS8", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0005874 microtubule;GO:0072686 mitotic spindle;GO:0005856 cytoskeleton", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0000226 microtubule cytoskeleton organization;GO:0031115 negative regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TNG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGQ6-1", "uniprot_id": "EFC14_MOUSE", "mass": 53694.0, "length": 484, "protein_name": "EF-hand calcium-binding domain-containing protein 14", "gene_name": "Efcab14", "organism": "Mouse", "refseq_name": "EF-hand calcium-binding domain-containing protein 14 isoform 2", "refseq_ac": "NP_001355556", "gene_names_uniprotkb": "Efcab14; 4732418C07Rik; Kiaa0494", "gene_names_refseq": "4732418C07Rik; Efcab14", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 14", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 14 isoform 2; EF-hand calcium-binding domain-containing protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:230648)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2A8U1;Q3TQN6;Q8BJV7;Q8C0R1", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BGQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVG4-1", "uniprot_id": "DPP9_MOUSE", "mass": 98001.0, "length": 862, "protein_name": "Dipeptidyl peptidase 9", "gene_name": "Dpp9", "organism": "Mouse", "refseq_name": "dipeptidyl peptidase 9 isoform 2", "refseq_ac": "NP_766212", "gene_names_uniprotkb": "Dpp9", "gene_names_refseq": "6430584G11Rik; A330078I11; DPP IX; DPRP2; Dpp9", "protein_names_uniprotkb": "Dipeptidyl peptidase 9; 3.4.14.5; DP9; DPLP9; DPP IX; Dipeptidyl peptidase IX; Dipeptidyl peptidase-like protein 9", "protein_names_refseq": "DP9; DPLP9; dipeptidyl peptidase 9 isoform 2; dipeptidyl peptidase IX; dipeptidyl peptidase-like protein 9", "tax_id": 10090, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (mmu:224897)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "19581630;23704821;24223149;25428506;27820798;28528544;28887018;29396289;31086209;31219806;34428180;36112693;38531482", "class_list": "", "function": "DP8 and DP9 tissue and cellular expression, [RefSeq, PubMed]; DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling., [RefSeq, PubMed]; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:24223149). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29396289). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (By similarity). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer., [RefSeq, PubMed]; Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity. Publication Status: Online-Only, [RefSeq, PubMed]; Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAM9;Q8BWT9", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0042802 identical protein binding;GO:0004177 aminopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0031252 cell leading edge", "go_biological_process": "GO:1904784 NLRP1 inflammasome complex assembly;GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0070269 pyroptotic inflammatory response;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BVG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C7X2-1", "uniprot_id": "EMC1_MOUSE", "mass": 111605.0, "length": 997, "protein_name": "ER membrane protein complex subunit 1", "gene_name": "Emc1", "organism": "Mouse", "refseq_name": "ER membrane protein complex subunit 1 isoform 2 precursor", "refseq_ac": "NP_001034289", "gene_names_uniprotkb": "Emc1; Kiaa0090", "gene_names_refseq": "2700016F22Rik; Emc1", "protein_names_uniprotkb": "ER membrane protein complex subunit 1", "protein_names_refseq": "ER membrane protein complex subunit 1 isoform 2 precursor; novel DUF1620 domain containing protein", "tax_id": 10090, "disease": "cerebellar atrophy, visual impairment, and psychomotor retardation (Disease Ontology:DOID:0081276); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (mmu:230866)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;25428506;25605945;26495903;30084848;30779550;30899004;31219806;32152506;34203471;34428180;35820727;37098815;37507081", "class_list": "", "function": "Deletion of Emc1 in photoreceptor cells causes retinal degeneration in mice., [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RTJ5;Q3TCG4;Q6ZQJ4;Q8K3W8", "ec_number_list": "", "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8C7X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z67-1", "uniprot_id": "SRGP2_MOUSE", "mass": 120798.0, "length": 1071, "protein_name": "SLIT-ROBO Rho GTPase-activating protein 2", "gene_name": "Srgap2", "organism": "Mouse", "refseq_name": "SLIT-ROBO Rho GTPase-activating protein 2", "refseq_ac": "NP_001074480", "gene_names_uniprotkb": "Srgap2; Fbp27; Fnbp2", "gene_names_refseq": "9930124L22Rik; FBP2; Fnbp2; Srgap2; srGAP3", "protein_names_uniprotkb": "SLIT-ROBO Rho GTPase-activating protein 2; FBP-27; Formin-binding protein 27; Formin-binding protein 2; srGAP2", "protein_names_refseq": "FBP-27; SLIT-ROBO Rho GTPase-activating protein 2; formin binding protein 2; formin-binding protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:14270); (R-MMU-5663220); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013406); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11672528;19737524;21148482;21183079;21750661;22126966;22517741;22559944;26439400;26495903;27373832;28528544;31219806;33300544;34203471;34428180;36852467;40885482;8605874", "class_list": "", "function": "Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:19737524, PubMed:22559944, PubMed:27373832). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:19737524, PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (PubMed:27373832). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:19737524, PubMed:22559944, PubMed:26439400). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (PubMed:26439400). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:22559944)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RY13;Q3V1V8;Q61054", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0003363 lamellipodium assembly involved in ameboidal cell migration;GO:1904861 excitatory synapse assembly;GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q91Z67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXB6-1", "uniprot_id": "SO2B1_MOUSE", "mass": 74531.0, "length": 683, "protein_name": "Solute carrier organic anion transporter family member 2B1", "gene_name": "Slco2b1", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 2B1 isoform 1", "refseq_ac": "NP_001239459", "gene_names_uniprotkb": "Slco2b1; Oatp2b1; Slc21a9", "gene_names_refseq": "OATP-B; OATP2B1; Slc21a9; Slco2b1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 2B1; OATP2B1; Organic anion transporting polypeptide 2B1; Solute carrier family 21 member 9", "protein_names_refseq": "organic anion transporting polypeptide 2B1; solute carrier family 21 (organic anion transporter), member 9; solute carrier family 21 member 9; solute carrier organic anion transporter family member 2B1 isoform 1", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); liver cancer (Disease Ontology:DOID:3571)", "pathway": " (mmu:101488); (R-MMU-189483); (R-MMU-879518); (R-MMU-9749641); (R-MMU-9754706)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "17208939;18630941;20173027;21750661;31123035;31219806;32114507;34428180;35714613", "class_list": "", "function": "Mediates the Na(+)-independent transport of steroid sulfate conjugates such as estrone 3-sulfate (E1S), dehydroepiandrosterone sulfate (DHEA-S) and pregnenolone sulfate (PregS) and other specific organic anions (PubMed:31123035). Responsible for the transport of E1S through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including DHEA-S (By similarity). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver. Mediates the intestinal uptake of sulfated steroids. Mediates the uptake of the neurosteroids DHEA-S and PregS into the endothelial cells of the blood-brain barrier as the first step to enter the brain. Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons. May act as a heme transporter that promotes cellular iron availability. Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (By similarity). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:31123035). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound. Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions. Cytoplasmic glutamate may also act as counteranion in the placenta. An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability. Erratum:[Mol Cell. 2022 Oct 6;82(19):3750. doi: 10.1016/j.molcel.2022.09.004. PMID: 36206741], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLV8", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071718 sodium-independent icosanoid transport;GO:0008283 cell population proliferation;GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BXB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924H7-1", "uniprot_id": "WAC_MOUSE", "mass": 70680.0, "length": 646, "protein_name": "WW domain-containing adapter protein with coiled-coil", "gene_name": "Wac", "organism": "Mouse", "refseq_name": "WW domain-containing adapter protein with coiled-coil isoform 2", "refseq_ac": "NP_001139770", "gene_names_uniprotkb": "Wac; Kiaa1844", "gene_names_refseq": "1110067P07Rik; A230035H12Rik; Wac; Wwp4", "protein_names_uniprotkb": "WW domain-containing adapter protein with coiled-coil", "protein_names_refseq": "WW domain-containing adapter protein with coiled-coil isoform 2; WW domain-containing adapter protein with coiled-coil; WW domain-containing protein 4", "tax_id": 10090, "disease": "DeSanto-Shinawi syndrome (Disease Ontology:DOID:0081126)", "pathway": " (mmu:225131); (R-MMU-8866654)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11827461;17242355;21750661;28528544;30084848;31219806;32782141;34428180;36852467;37171241;37402055;40885482;40997131", "class_list": "", "function": "Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression analyses of WAC, a responsible gene for neurodevelopmental disorders, during mouse brain development., [RefSeq, PubMed]; The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0K1;Q66JM9;Q69Z92;Q8C2W2;Q8C8Q8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010506 regulation of autophagy;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q924H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A9C3-1", "uniprot_id": "SZT2_MOUSE", "mass": 377627.0, "length": 3431, "protein_name": "KICSTOR complex protein SZT2", "gene_name": "Szt2", "organism": "Mouse", "refseq_name": "KICSTOR complex protein SZT2", "refseq_ac": "NP_937813", "gene_names_uniprotkb": "Szt2", "gene_names_refseq": "6430407N22; Szt2; TIGR", "protein_names_uniprotkb": "KICSTOR complex protein SZT2; Seizure threshold 2 protein; TIGR; Transcript increased in glutamate resistance", "protein_names_refseq": "KICSTOR complex protein SZT2; Seizure threshold 2 protein; Transcript increased in glutamate resistance; seaizure threshold 2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 18 (Disease Ontology:DOID:0080413)", "pathway": " (mmu:230676); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19624305;20045724;21750661;28199306;28199315;31219806;34428180;36250465", "class_list": "", "function": "As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids (By similarity). In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (PubMed:20045724)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; In mice that lack SZT2, mTORC1 signalling is increased in several tissues, including in neurons in the brain, [RefSeq, PubMed]; SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment Erratum:[Nature. 2018 Jun;558(7710):E2. doi: 10.1038/s41586-018-0114-2. PMID: 29769712], [RefSeq, PubMed]; SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation. Publication Status: Online-Only, [RefSeq, PubMed]; While the biological function of Szt2 remains unknown, its high conservation, unique structure and effect on seizure threshold suggest that it serves an important role in the central nervous system., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PB77;Q7TSS6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0140007 KICSTOR complex;GO:0005777 peroxisome;GO:0005765 lysosomal membrane;GO:1990130 GATOR1 complex;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1901668 regulation of superoxide dismutase activity;GO:0031667 response to nutrient levels;GO:0007417 central nervous system development;GO:0009791 post-embryonic development;GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2A9C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTN3-1", "uniprot_id": "SRBP1_MOUSE", "mass": 120537.0, "length": 1134, "protein_name": "Sterol regulatory element-binding protein 1", "gene_name": "Srebf1", "organism": "Mouse", "refseq_name": "sterol regulatory element-binding protein 1 isoform b", "refseq_ac": "NP_001300908", "gene_names_uniprotkb": "Srebf1; Srebp1", "gene_names_refseq": "ADD1; SREBP1; Srebf1; bHLHd1", "protein_names_uniprotkb": "Sterol regulatory element-binding protein 1; SREBP-1; Sterol regulatory element-binding transcription factor 1; Transcription factor SREBF1", "protein_names_refseq": "adipocyte determination- and differentiation-dependent factor 1; sterol regulatory element-binding protein 1 isoform b; sterol regulatory element-binding protein 1", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); heart conduction disease (Disease Ontology:DOID:10273); alcoholic hepatitis (Disease Ontology:DOID:12351); alcohol use disorder (Disease Ontology:DOID:1574); coronary artery disease (Disease Ontology:DOID:3393); kidney disease (Disease Ontology:DOID:557); type 2 diabetes mellitus (Disease Ontology:DOID:9352); lipid storage disease (Disease Ontology:DOID:9455); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:20787)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10052151;11782483;11929849;12855691;16100574;17290224;19244231;19786558;21183079;21459323;21531336;21750661;21987372;22384276;26311497;28849786;30084848;31219806;32782141;34428180;39491648;8833906;9062340;9062341;9329978;9784493", "class_list": "", "function": "Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (PubMed:12855691, PubMed:21531336). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:8833906). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (PubMed:12855691, PubMed:9062341). Required for innate immune response in macrophages by regulating lipid metabolism (PubMed:21531336)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:17290224, PubMed:19244231, PubMed:21459323, PubMed:9329978, PubMed:9784493). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (By similarity). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:17290224, PubMed:19244231, PubMed:21459323, PubMed:9329978, PubMed:9784493)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:11782483, PubMed:12855691, PubMed:19244231). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:11782483, PubMed:12855691, PubMed:16100574, PubMed:19244231)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (PubMed:12855691, PubMed:21531336). Primarily controls expression of lipogenic gene (PubMed:8833906, PubMed:9062341). Strongly activates global lipid synthesis in rapidly growing cells (PubMed:8833906, PubMed:9062341)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U458;Q3UDJ3;Q5SRX5;Q8C733;Q99JK7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9WTN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBY1-1", "uniprot_id": "SMAG1_MOUSE", "mass": 78359.0, "length": 711, "protein_name": "Protein Smaug homolog 1", "gene_name": "Samd4a; Samd4", "organism": "Mouse", "refseq_name": "protein Smaug homolog 1 isoform 1", "refseq_ac": "NP_001032298", "gene_names_uniprotkb": "Samd4a; Samd4; Samd4; Smaug1", "gene_names_refseq": "1700024G08Rik; 1700111L17Rik; 4933436G17Rik; Samd4a; Samd4; Smaug1; Smaug; sunk", "protein_names_uniprotkb": "Protein Smaug homolog 1; Smaug 1; Sterile alpha motif domain-containing protein 4A; mSmaug 1", "protein_names_refseq": "protein Smaug homolog 1 isoform 1; protein Smaug homolog 1; smaug 1; sterile alpha motif domain-containing protein 4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:74480)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16221671;21750661;24129315;24799716;28528544;31219806;32782141;34080649;36852467;40885482", "class_list": "", "function": "Acts as a translational repressor of SRE-containing messengers., [UniProtKB]; CircSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR29c3pmediated AMPK/mTOR pathway in Parkinson's disease., [RefSeq, PubMed]; Samd4 has a role in leanness, myopathy, uncoupled mitochondrial respiration, and regulation of mTORC1 signaling, [RefSeq, PubMed]; Smaug 1 has a role in RNA granule formation and translation regulation in neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6H6C5;Q2VA55;Q3TQA5;Q3TTN7;Q3UZ00;Q9D3T3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0030371 translation repressor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030425 dendrite;GO:0045202 synapse;GO:0000932 P-body;GO:0005737 cytoplasm", "go_biological_process": "GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CBY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDJ3-1", "uniprot_id": "VIGLN_MOUSE", "mass": 141743.0, "length": 1268, "protein_name": "Vigilin", "gene_name": "Hdlbp", "organism": "Mouse", "refseq_name": "vigilin isoform 1", "refseq_ac": "NP_001288293", "gene_names_uniprotkb": "Hdlbp", "gene_names_refseq": "1110005P14Rik; D1Ertd101e; Hdlbp", "protein_names_uniprotkb": "Vigilin; HDL-binding protein; High density lipoprotein-binding protein", "protein_names_refseq": "HDL-binding protein; high density lipoprotein-binding protein; vigilin isoform 1; vigilin", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:110611); (R-MMU-8964011)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16075062;16452087;17242355;18630941;21183079;21750661;23806337;28528544;29187734;30084848;34428180;34887587;35585045;36288343;37453647;37828378;39627609", "class_list": "", "function": "Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0034364 high-density lipoprotein particle;GO:0016604 nuclear body;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8VDJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2P8-1", "uniprot_id": "VAMP5_MOUSE", "mass": 11416.0, "length": 102, "protein_name": "Vesicle-associated membrane protein 5", "gene_name": "Vamp5", "organism": "Mouse", "refseq_name": "vesicle-associated membrane protein 5", "refseq_ac": "NP_001074211", "gene_names_uniprotkb": "Vamp5", "gene_names_refseq": "Camp; Vamp5", "protein_names_uniprotkb": "Vesicle-associated membrane protein 5; Myobrevin; VAMP-5", "protein_names_refseq": "VAMP-5; myobrevin; vesicle-associated membrane protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:53620)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12682051;17242355;21183079;21750661;23180306;29330887;38265888;9725904", "class_list": "", "function": "Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung, [RefSeq, PubMed]; May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking., [UniProtKB]; Study found that VAMP5 was expressed in the type IIa fibers of skeletal muscle and that in cardiomyocytes, VAMP5 expression was localized to the vicinity of intercalated discs, [RefSeq, PubMed]; The cytoplasmic domain of this protein is responsible for its correct subcellular targeting., [RefSeq, PubMed]; VAMP5 promotes Fcgamma receptor-mediated phagocytosis and regulates phagosome maturation in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0014704 intercalated disc;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0043001 Golgi to plasma membrane protein transport;GO:0007519 skeletal muscle tissue development;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z2P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W86-1", "uniprot_id": "VPS11_MOUSE", "mass": 107719.0, "length": 941, "protein_name": "Vacuolar protein sorting-associated protein 11 homolog", "gene_name": "Vps11", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 11 homolog isoform 1", "refseq_ac": "NP_082165", "gene_names_uniprotkb": "Vps11", "gene_names_refseq": "1200011A11Rik; Vps11", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 11 homolog", "protein_names_refseq": "vacuolar protein sorting 11; vacuolar protein sorting-associated protein 11 homolog isoform 1; vacuolar protein sorting-associated protein 11 homolog", "tax_id": 10090, "disease": "hypomyelinating leukoencephalopathy (Disease Ontology:DOID:0050987); hypomyelinating leukodystrophy 12 (Disease Ontology:DOID:0060796); dystonia 32 (Disease Ontology:DOID:0060939)", "pathway": " (mmu:71732)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21411634;21750661;24129315;25266290;25428506;30084848;31219806;33874780;34203471;34428180;35820727;36210013", "class_list": "", "function": "Characterization of the Expression of Vacuolar Protein Sorting 11 (Vps11) in Mammalian Oligodendrocytes., [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWZ1;Q9DBX8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0000166 nucleotide binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005884 actin filament;GO:0005764 lysosome", "go_biological_process": "GO:0048284 organelle fusion;GO:1902115 regulation of organelle assembly;GO:0006886 intracellular protein transport;GO:0007032 endosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91W86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AIV2-1", "uniprot_id": "VIR_MOUSE", "mass": 201439.0, "length": 1811, "protein_name": "Protein virilizer homolog", "gene_name": "Virma", "organism": "Mouse", "refseq_name": "protein virilizer homolog isoform 2", "refseq_ac": "NP_001333984", "gene_names_uniprotkb": "Virma; 1110037F02Rik; Kiaa1429", "gene_names_refseq": "1110037F02Rik; 4930422M05Rik; Kiaa1429; Virma; mKIAA1429", "protein_names_uniprotkb": "Protein virilizer homolog", "protein_names_refseq": "protein virilizer homolog isoform 2; protein virilizer homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66185)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;19224205;20173027;21183079;21750661;24129315;25428506;25605945;29535189;29547716;30084848;30779550;31219806;32152506;33300544;34203471;34418053;34428180;35820727;35987159;36572002;39627609", "class_list": "", "function": "Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA)., [UniProtKB, UniProtKB]; KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells., [RefSeq, PubMed]; Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m[6]A deposition to activate the PI3K/AKT signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AIV1;Q3TDQ3;Q3TRR9;Q3U1Z2;Q80TD6;Q8C758;Q8K151;Q9CSI3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "A2AIV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TB8-1", "uniprot_id": "VAT1L_MOUSE", "mass": 45817.0, "length": 417, "protein_name": "Putative NADPH-dependent quinone oxidoreductase VAT1L", "gene_name": "Vat1l", "organism": "Mouse", "refseq_name": "putative NADPH-dependent quinone oxidoreductase VAT1L", "refseq_ac": "NP_766604", "gene_names_uniprotkb": "Vat1l; Kiaa1576", "gene_names_refseq": "9430073I07; Vat1l; mKIAA1576", "protein_names_uniprotkb": "Putative NADPH-dependent quinone oxidoreductase VAT1L; 1.6.5.5; Synaptic vesicle membrane protein VAT-1 homolog-like; Vesicle amine transport protein 1 like", "protein_names_refseq": "putative NADPH-dependent quinone oxidoreductase VAT1L; vesicle amine transport protein 1 homolog-like (T. californica)", "tax_id": 10090, "disease": "", "pathway": " (mmu:270097)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;25428506;31219806;33300544", "class_list": "", "function": "Putative NADPH-dependent quinone oxidoreductase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGM9", "ec_number_list": "1.6.5.5", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003960 quinone reductase (NADPH) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80TB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62468-1", "uniprot_id": "VILI_MOUSE", "mass": 92775.0, "length": 827, "protein_name": "Villin-1", "gene_name": "Vil1", "organism": "Mouse", "refseq_name": "villin-1", "refseq_ac": "NP_033535", "gene_names_uniprotkb": "Vil1; Vil", "gene_names_refseq": "Vil1; Vil", "protein_names_uniprotkb": "Villin-1", "protein_names_refseq": "villin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22349)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10459016;12937273;16008578;1601186;18198174;21183079;21750661", "class_list": "", "function": "Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149B6;Q91WH4", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0061041 regulation of wound healing;GO:0051125 regulation of actin nucleation;GO:0001951 intestinal D-glucose absorption", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62468-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62442-1", "uniprot_id": "VAMP1_MOUSE", "mass": 12890.0, "length": 118, "protein_name": "Vesicle-associated membrane protein 1", "gene_name": "Vamp1", "organism": "Mouse", "refseq_name": "vesicle-associated membrane protein 1 isoform b", "refseq_ac": "NP_001074026", "gene_names_uniprotkb": "Vamp1; Syb1", "gene_names_refseq": "Syb-1; Syb1; VAMP-1; Vamp1; lew", "protein_names_uniprotkb": "Vesicle-associated membrane protein 1; Synaptobrevin-1; VAMP-1", "protein_names_refseq": "synaptobrevin-1; vesicle-associated membrane protein 1 isoform b", "tax_id": 10090, "disease": "spastic ataxia 1 (Disease Ontology:DOID:0050772); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (mmu:22317)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17102983;21183079;21750661;28770820;29621484;32209659", "class_list": "", "function": "Involved in the targeting and/or fusion of transport vesicles to their target membrane., [UniProtKB]; MicroRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens., [RefSeq, PubMed]; Vamp1 is strongly down-regulated in Rbfox1 knock-out mice which contributes to regulation of synaptic transmission., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFF3;Q810K6", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0035493 SNARE complex assembly;GO:0006906 vesicle fusion;GO:0016082 synaptic vesicle priming;GO:0045055 regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62442-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XD6-1", "uniprot_id": "VPS36_MOUSE", "mass": 43736.0, "length": 386, "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "Vps36", "organism": "Mouse", "refseq_name": "vacuolar protein-sorting-associated protein 36 isoform 1", "refseq_ac": "NP_081614", "gene_names_uniprotkb": "Vps36", "gene_names_refseq": "1700010A24Rik; 2210415M20Rik; 2810408E15Rik; Eap45; Vps36", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36", "protein_names_refseq": "ESCRT-II complex subunit VPS36; vacuolar protein-sorting-associated protein 36 isoform 1; vacuolar protein-sorting-associated protein 36", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:70160); (R-MMU-917729)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15755741;17057714;25428506;32782141;32848054;34428180;36852467;37507081;40885482", "class_list": "", "function": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3., [UniProtKB, UniProtKB, PubMed]; Presentation of the complex structure of Eap45 GLUE and ubiquitin at 3.35 A resolution, which explains the previously uncharacterized mechanism of Ub recognition by mammalian ESCRT-II, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVA3", "ec_number_list": "", "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006351 DNA-templated transcription;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91XD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMD3-1", "uniprot_id": "STA10_MOUSE", "mass": 32951.0, "length": 291, "protein_name": "START domain-containing protein 10", "gene_name": "Stard10", "organism": "Mouse", "refseq_name": "START domain-containing protein 10 isoform 2", "refseq_ac": "NP_064374", "gene_names_uniprotkb": "Stard10; Pctpl; Sdccag28; Sdccagg28", "gene_names_refseq": "CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl; Sdccag28; SdccagG28; Stard10; TISP-81", "protein_names_uniprotkb": "START domain-containing protein 10; PCTP-L; PCTP-like protein; Serologically defined colon cancer antigen 28 homolog; StAR-related lipid transfer protein 10; StARD10", "protein_names_refseq": "PCTP-L; PCTP-like protein; START domain containing 10; START domain-containing protein 10 isoform 2; START domain-containing protein 10; serologically defined colon cancer antigen 10; serologically defined colon cancer antigen 28 homolog; stAR-related lipid transfer protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:56018); (R-MMU-1483191)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10819773;14576202;21183079;21750661;23200860;23806337;28132686;32416313;34428180;37453647;37507081", "class_list": "", "function": "Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes (By similarity). May play metabolic roles in sperm maturation or fertilization., [UniProtKB, PubMed]; Results indicate that STARD10 is involved in regulating bile acid metabolism through the modulation of PPARalpha-mediated mechanism., [RefSeq, PubMed]; StarD10 is required for normal insulin secretion, though its deletion enhances proinsulin processing., [RefSeq, PubMed]; Stard10 (Sdccag28) is much more highly transcribed in cardiac atria than in cardiac ventricles., [RefSeq, PubMed]; The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0031514 motile cilium;GO:0046581 intercellular canaliculus;GO:0005902 microvillus", "go_biological_process": "GO:0006869 lipid transport;GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0032782 bile acid secretion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JMD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ11-1", "uniprot_id": "TACC3_MOUSE", "mass": 70627.0, "length": 631, "protein_name": "Transforming acidic coiled-coil-containing protein 3", "gene_name": "Tacc3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tacc3; Aint", "gene_names_refseq": "", "protein_names_uniprotkb": "Transforming acidic coiled-coil-containing protein 3; ARNT-interacting protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10366448;11025203;17920017;21750661;31219806;34428180", "class_list": "", "function": "Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (PubMed:17920017). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). May be involved in the control of cell growth and differentiation. May have a role in embryonic development., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVK9", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:1902850 microtubule cytoskeleton organization involved in mitosis;GO:0008283 cell population proliferation;GO:0051301 cell division;GO:0001666 response to hypoxia;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJ11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11983-1", "uniprot_id": "TCPA_MOUSE", "mass": 60449.0, "length": 556, "protein_name": "T-complex protein 1 subunit alpha", "gene_name": "Tcp1", "organism": "Mouse", "refseq_name": "T-complex protein 1 subunit alpha isoform 2", "refseq_ac": "NP_001277641", "gene_names_uniprotkb": "Tcp1; Cct1; Ccta", "gene_names_refseq": "CCT; Cct1; Ccta; TRic; Tcp-1; Tcp1; Tp63; c-cpn; p63", "protein_names_uniprotkb": "T-complex protein 1 subunit alpha; 3.6.1.-; CCT-alpha; TCP-1-A; TCP-1-B; TCP-1-alpha; Tailless complex polypeptide 1A; Tailless complex polypeptide 1B", "protein_names_refseq": "CCT-alpha; T-complex protein 1 subunit alpha A; T-complex protein 1 subunit alpha B; T-complex protein 1 subunit alpha isoform 2; TCP-1-A; TCP-1-B; TCP-1-alpha; t-complex polypeptide 1; tailless complex polypeptide 1A; tailless complex polypeptide 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:21454); (R-MMU-390471); (R-MMU-5620922); (R-MMU-6814122)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "1383093;1937024;21183079;21750661;22645316;2377466;23806337;24788674;25428506;25605945;26495903;26740625;30084848;31599954;33300544;34428180;34600884;34887587;34896365;35820727;37453647;37507081;3753900;37828378;39627609", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB]; Resistance of Acta2(R149C/+) mice to aortic disease is associated with defective release of mutant smooth muscle alpha-actin from the chaperonin-containing TCP1 folding complex., [RefSeq, PubMed]; The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11984;Q3TJ96;Q3TKU1;Q3U5T8;Q3U7I8;Q3UAA8;Q3UB80;Q3UE48", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.1.91;2.3.1.-;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0043209 myelin sheath;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0090666 scaRNA localization to Cajal body;GO:0007339 binding of sperm to zona pellucida;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P11983-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UK10-1", "uniprot_id": "B9D2_MOUSE", "mass": 19250.0, "length": 175, "protein_name": "B9 domain-containing protein 2", "gene_name": "B9d2", "organism": "Mouse", "refseq_name": "B9 domain-containing protein 2", "refseq_ac": "NP_742160", "gene_names_uniprotkb": "B9d2", "gene_names_refseq": "B9d2; stumpy", "protein_names_uniprotkb": "B9 domain-containing protein 2; Stumpy", "protein_names_refseq": "B9 domain-containing protein 2", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); ciliopathy (Disease Ontology:DOID:0060340)", "pathway": " (mmu:232987); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "18287022;21750661;21763481;22179047;25605945", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R045", "ec_number_list": "", "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0016020 membrane;GO:0005930 axoneme;GO:0036038 MKS complex", "go_biological_process": "GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UK10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J87-1", "uniprot_id": "DHX58_MOUSE", "mass": 76709.0, "length": 678, "protein_name": "ATP-dependent RNA helicase DHX58", "gene_name": "Dhx58", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DHX58", "refseq_ac": "NP_084426", "gene_names_uniprotkb": "Dhx58; D11lgp2e; Lgp2", "gene_names_refseq": "B430001I08Rik; D11Lgp2e; Dhx58; LPG2; Lgp2; RLR-3", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX58; 3.6.4.13; ATP-dependent helicase LGP2; Protein D11Lgp2; RIG-I-like receptor 3; RIG-I-like receptor Lgp2; RLR-3; RLR", "protein_names_refseq": "ATP-dependent RNA helicase DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58; RIG-I-like receptor 3; RIG-I-like receptor Lgp2; RLR; RNA helicase LGP2; probable ATP-dependent RNA helicase DHX58; probable ATP-dependent helicase LGP2; protein D11Lgp2", "tax_id": 10090, "disease": "Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (mmu:80861)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11161808;11735219;16210631;17473309;17475874;20080593;21481967;21496944;21525357;21533147;21616437;26740625;30059200;33087322;34428180;38622688", "class_list": "", "function": "Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Interferon-alpha stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering double-stranded RNA from retinoic acid-inducible gene-I (RIG-I)., [RefSeq, PubMed]; RIG-I-Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A5E9;Q9D1X4", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0009617 response to bacterium;GO:0009615 response to virus;GO:1900245 positive regulation of MDA-5 signaling pathway;GO:1900246 positive regulation of RIG-I signaling pathway;GO:0032481 positive regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q99J87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70237-1", "uniprot_id": "GFI1B_MOUSE", "mass": 37443.0, "length": 330, "protein_name": "Zinc finger protein Gfi-1b", "gene_name": "Gfi1b", "organism": "Mouse", "refseq_name": "zinc finger protein Gfi-1b isoform 1", "refseq_ac": "NP_032140", "gene_names_uniprotkb": "Gfi1b", "gene_names_refseq": "Gfi-1B; Gfi1b", "protein_names_uniprotkb": "Zinc finger protein Gfi-1b; Growth factor independent protein 1B", "protein_names_refseq": "growth factor independent protein 1B; zinc finger protein Gfi-1b isoform 1; zinc finger protein Gfi-1b", "tax_id": 10090, "disease": "myeloid neoplasm (Disease Ontology:DOID:0070004); gray platelet syndrome (Disease Ontology:DOID:0111044); platelet-type bleeding disorder 17 (Disease Ontology:DOID:0111049); aplastic anemia (Disease Ontology:DOID:12449); alcohol use disorder (Disease Ontology:DOID:1574); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14582)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11696536;11825872;12351384;12594258;15718298;15920471;17095621;17707228;36649572;38820141;9566867", "class_list": "", "function": "Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs., [RefSeq, PubMed]; Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U039", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016363 nuclear matrix;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045646 regulation of erythrocyte differentiation;GO:1903706 regulation of hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70237-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35099-1", "uniprot_id": "M3K5_MOUSE", "mass": 154512.0, "length": 1380, "protein_name": "Mitogen-activated protein kinase kinase kinase 5", "gene_name": "Map3k5", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 5", "refseq_ac": "NP_032606", "gene_names_uniprotkb": "Map3k5; Ask1; Mekk5", "gene_names_refseq": "7420452D20Rik; ASK1; ASK; MAPKKK5; Map3k5; Mekk5", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 5; 2.7.11.25; ASK-1; Apoptosis signal-regulating kinase 1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5", "protein_names_refseq": "ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; apoptosis signal-regulating kinase 1; mitogen-activated protein kinase kinase kinase 5", "tax_id": 10090, "disease": "membranous glomerulonephritis (Disease Ontology:DOID:10976); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); amphetamine abuse (Disease Ontology:DOID:670); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (mmu:26408); (R-MMU-2559580)", "pathway_count": 2, "publication_count": 36, "publication_id_list": "11266364;11920685;14749717;15864310;16527894;16648474;17015619;17342315;17456047;17883330;18948261;19389260;21750661;22399290;22517741;22530568;22645316;25428506;26317424;27063938;28939911;31219806;32121597;32242025;32848054;33063955;33108364;34428180;36210013;36473935;38721693;38839869;39488570;40021952;40885482;9367868", "class_list": "", "function": "ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice. Publication Status: Online-Only, [RefSeq, PubMed]; ASK1-ER stress pathway-mediated fibrotic-EV release contributes to the interaction of alveolar epithelial cells and lung fibroblasts to promote mechanical ventilation-induced pulmonary fibrosis., [RefSeq, PubMed]; Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging. Publication Status: Online-Only, [RefSeq, PubMed]; Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q14AY5", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:1990604 IRE1-TRAF2-ASK1 complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "O35099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XS6-1", "uniprot_id": "SMAG2_MOUSE", "mass": 75024.0, "length": 687, "protein_name": "Protein Smaug homolog 2", "gene_name": "Samd4b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Samd4b; Smaug2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Smaug homolog 2; Smaug 2; Sterile alpha motif domain-containing protein 4B; mSmaug2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:233033)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19144319;21183079;21750661;24129315;31219806;34428180", "class_list": "", "function": "Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0030371 translation repressor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0005737 cytoplasm", "go_biological_process": "GO:0098749 cerebellar neuron development;GO:0006351 DNA-templated transcription;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80XS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWZ7-1", "uniprot_id": "SNAG_MOUSE", "mass": 34732.0, "length": 312, "protein_name": "Gamma-soluble NSF attachment protein", "gene_name": "Napg", "organism": "Mouse", "refseq_name": "gamma-soluble NSF attachment protein isoform 1", "refseq_ac": "NP_082293", "gene_names_uniprotkb": "Napg; Snapg", "gene_names_refseq": "2400003O04Rik; Napg; SNARE", "protein_names_uniprotkb": "Gamma-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein gamma; SNAP-gamma", "protein_names_refseq": "N-ethylmaleimide-sensitive factor attachment protein gamma; SNAP-gamma; gamma-soluble NSF attachment protein isoform 1; gamma-soluble NSF attachment protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:108123); (R-MMU-204005); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16075062;17114649;21183079;21750661;26495903;8455721;9705316", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9868, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPT4", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045202 synapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CWZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0B0-1", "uniprot_id": "SRSF9_MOUSE", "mass": 25661.0, "length": 222, "protein_name": "Serine/arginine-rich splicing factor 9", "gene_name": "Srsf9", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 9", "refseq_ac": "NP_079849", "gene_names_uniprotkb": "Srsf9; Sfrs9", "gene_names_refseq": "25kDa; 2610029M16Rik; SRp30c; Sfrs9; Srsf9", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 9; Splicing factor, arginine/serine-rich 9", "protein_names_refseq": "serine/arginine-rich splicing factor 9; splicing factor, arginine/serine-rich 9", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054)", "pathway": " (mmu:108014); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10823932;11118435;16249178;21750661;29733375;34428180;38810124", "class_list": "", "function": "Cooperative action of multiple SR proteins in the regulation of GnRH pre-mRNA splicing; SRp30c specifically binds to both ESE3 and ESE4, [RefSeq, PubMed]; Data show that editing of Cav1.3 calcium channel (CaV1.3) was potently inhibited by serine/arginine-rich splicing factor 9 (SRSF9)., [RefSeq, PubMed]; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (By similarity)., [UniProtKB]; The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4., [RefSeq, PubMed]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRN3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D0B0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGQ1-1", "uniprot_id": "SPE39_MOUSE", "mass": 56625.0, "length": 491, "protein_name": "Spermatogenesis-defective protein 39 homolog", "gene_name": "Vipas39", "organism": "Mouse", "refseq_name": "spermatogenesis-defective protein 39 homolog isoform a", "refseq_ac": "NP_001136052", "gene_names_uniprotkb": "Vipas39; Spe39; Vipar", "gene_names_refseq": "6720456H09Rik; 9330175H22Rik; SPE-39; Spe39; Vipar; Vipas39; hSPE-39", "protein_names_uniprotkb": "Spermatogenesis-defective protein 39 homolog; VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; hSPE-39", "protein_names_refseq": "VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; protein spe-39 homolog; spermatogenesis-defective protein 39 homolog isoform a; spermatogenesis-defective protein 39 homolog", "tax_id": 10090, "disease": "ARC syndrome (Disease Ontology:DOID:0050763); arthrogryposis, renal dysfunction, and cholestasis 2 (Disease Ontology:DOID:0111354)", "pathway": " (mmu:104799)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;20190753;21183079;29409756;31219806;34428180", "class_list": "", "function": "Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin., [UniProtKB, UniProtKB, PubMed, UniProtKB]; VPS33B and VIPAR are essential for epidermal lamellar body biogenesis and function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL55;Q8CIK4;Q91YI3", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0055037 recycling endosome", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BGQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C624-1", "uniprot_id": "SPT33_MOUSE", "mass": 15038.0, "length": 132, "protein_name": "Spermatogenesis-associated protein 33", "gene_name": "Spata33", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 33", "refseq_ac": "NP_796253", "gene_names_uniprotkb": "Spata33", "gene_names_refseq": "4732415M23Rik; Spata33", "protein_names_uniprotkb": "Spermatogenesis-associated protein 33", "protein_names_refseq": "spermatogenesis-associated protein 33", "tax_id": 10090, "disease": "", "pathway": " (mmu:320869)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;23844118;33087875;34446558;35536443", "class_list": "", "function": "Plays an important role in sperm motility and male fertility (PubMed:34446558). Required for sperm midpiece flexibility and for the localization of sperm calcineurin to the mitochondria (PubMed:34446558). Promotes mitophagy as well as acts as an autophagy mediator in male germline cells (PubMed:33087875). Links damaged mitochondria to autophagosomes via its binding to the outer mitochondrial membrane protein VDAC2, as well as to key autophagy machinery component ATG16L1 (PubMed:33087875)., [UniProtKB, PubMed, PubMed]; Results indicate that Spata33 was predominantly expressed in the testis and associated with spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells., [RefSeq, PubMed]; SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009566 fertilization;GO:0030317 flagellated sperm motility;GO:0008104 intracellular protein localization;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C624-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWB1-1", "uniprot_id": "SYP2L_MOUSE", "mass": 102953.0, "length": 975, "protein_name": "Synaptopodin 2-like protein", "gene_name": "Synpo2l", "organism": "Mouse", "refseq_name": "synaptopodin 2-like protein isoform 3", "refseq_ac": "NP_001297361", "gene_names_uniprotkb": "Synpo2l", "gene_names_refseq": "1110054M18Rik; Chap; Synpo2l", "protein_names_uniprotkb": "Synaptopodin 2-like protein", "protein_names_refseq": "synaptopodin 2-like protein isoform 3; synaptopodin 2-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68760)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20215401;21183079;21750661;21948713;24129315;36288343;36852467;39195263;39927985", "class_list": "", "function": "Actin-associated protein that may play a role in modulating actin-based shape., [UniProtKB]; Analysis of CHAP expression in mouse during embryonic and adult stages; CHAP is expressed in the developing heart and somites, as well as muscle precursors of the limb buds in mouse and chick embryos, [RefSeq, PubMed]; Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Essential for heart and skeletal muscle function GeneRIF: Cloning and characterization of CHAP, both a sarcomeric and nuclear protein which is essential for striated muscle development and function. Two isoforms are described: ChapA is predominantly expressed in adult muscle and ChapB in embryonic/fetal muscle., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0015629 actin cytoskeleton;GO:0030018 Z disc;GO:0005737 cytoplasm;GO:0043226 organelle", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0051496 positive regulation of stress fiber assembly;GO:0003007 heart morphogenesis;GO:0035025 positive regulation of Rho protein signal transduction;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BWB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62277-1", "uniprot_id": "SYPH_MOUSE", "mass": 34025.0, "length": 314, "protein_name": "Synaptophysin", "gene_name": "Syp", "organism": "Mouse", "refseq_name": "synaptophysin", "refseq_ac": "NP_033331", "gene_names_uniprotkb": "Syp", "gene_names_refseq": "A230093K24Rik; Syn; Syp; p38", "protein_names_uniprotkb": "Synaptophysin; BM89 antigen; Major synaptic vesicle protein p38", "protein_names_refseq": "BM89 antigen; Syp I; major synaptic vesicle protein p38; synaptophysin", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 96 (Disease Ontology:DOID:0112035); Alzheimer's disease (Disease Ontology:DOID:10652); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:20977)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10595519;18034455;19196426;21183079;21750661;24995978;30084848;33300544;34203471;9210520", "class_list": "", "function": "Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRQ0;Q91WI8", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0015485 cholesterol binding;GO:0044877 protein-containing complex binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0006897 endocytosis;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0051260 protein homooligomerization;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62277-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VGY8-1", "uniprot_id": "TANC1_MOUSE", "mass": 200805.0, "length": 1856, "protein_name": "Protein TANC1", "gene_name": "Tanc1", "organism": "Mouse", "refseq_name": "protein TANC1 isoform b", "refseq_ac": "NP_001277588", "gene_names_uniprotkb": "Tanc1", "gene_names_refseq": "1200003E16Rik; Tanc1; Tanc; mKIAA1728", "protein_names_uniprotkb": "Protein TANC1; Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1", "protein_names_refseq": "TPR domain, ankyrin-repeat and coiled-coil-containing protein; protein TANC1 isoform b; protein TANC1; tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "intellectual developmental disorder with autistic features and language delay, with or without seizures (Disease Ontology:DOID:0081430)", "pathway": " (mmu:66860)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21068316;21183079;21750661;22645316;31219806;32782141;32848054;34418053;34428180;36852467;38092135;40885482", "class_list": "", "function": "May be a scaffold component in the postsynaptic density., [UniProtKB, UniProtKB, UniProtKB]; Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation., [RefSeq, PubMed]; These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "A2AUL4;A2AUL6;Q80VD2;Q8C0Q6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0008542 visual learning;GO:0007520 myoblast fusion;GO:0097062 dendritic spine maintenance;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q0VGY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70460-1", "uniprot_id": "VASP_MOUSE", "mass": 39667.0, "length": 375, "protein_name": "Vasodilator-stimulated phosphoprotein", "gene_name": "Vasp", "organism": "Mouse", "refseq_name": "vasodilator-stimulated phosphoprotein isoform 2", "refseq_ac": "NP_001268950", "gene_names_uniprotkb": "Vasp", "gene_names_refseq": "Vasp", "protein_names_uniprotkb": "Vasodilator-stimulated phosphoprotein; VASP", "protein_names_refseq": "vasodilator-stimulated phosphoprotein isoform 2", "tax_id": 10090, "disease": "tauopathy (Disease Ontology:DOID:680)", "pathway": " (mmu:22323); (R-MMU-376176); (R-MMU-446353)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "10069337;10085070;10660044;10882740;12372613;14506234;15642358;17242355;17901360;18250455;19144319;21183079;21945940;22216296;22922339;23613711;25605945;26495903;27620165;28011936;28935714;29176673;31793065;32579429;33129878;35757762;35984892;37828378;8812448", "class_list": "", "function": "Differential Ser phosphorylation of vasodilator-stimulated phosphoprotein regulates colon tumor formation and growth., [RefSeq, PubMed]; Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naive CD8(+) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity)., [UniProtKB, PubMed]; Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin., [RefSeq, PubMed]; Vasodilator-stimulated phosphoprotein (VASP) is recruited into dendritic spines via G-actin-dependent mechanism and contributes to spine enlargement and stabilization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAP0;Q3TCD2;Q3U0C2;Q3UDF1;Q91VD2;Q9R214", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0046847 filopodium assembly;GO:0051289 protein homotetramerization;GO:0030036 actin cytoskeleton organization;GO:0008154 actin polymerization or depolymerization;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P70460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62463-1", "uniprot_id": "V1AR_MOUSE", "mass": 47182.0, "length": 423, "protein_name": "Vasopressin V1a receptor", "gene_name": "Avpr1a", "organism": "Mouse", "refseq_name": "vasopressin V1a receptor", "refseq_ac": "NP_058543", "gene_names_uniprotkb": "Avpr1a", "gene_names_refseq": "AVPR; Avpr1a; Avpr1; V1aR; V1a", "protein_names_uniprotkb": "Vasopressin V1a receptor; AVPR V1a; Antidiuretic hormone receptor 1a; V1aR; Vascular/hepatic-type arginine vasopressin receptor", "protein_names_refseq": "AVPR V1a; V1a arginine vasopressin receptor; antidiuretic hormone receptor 1a; vascular/hepatic-type arginine vasopressin receptor; vasopressin V1a receptor", "tax_id": 10090, "disease": "portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); renovascular hypertension (Disease Ontology:DOID:1591); acute kidney failure (Disease Ontology:DOID:3021); brain edema (Disease Ontology:DOID:4724); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:54140); (R-MMU-388479); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10669045;12576226;14647484;17242355;21183079;38768798", "class_list": "", "function": "Identification of Arginine-Vasopressin Receptor 1a (Avpr1a/Avpr1a) as a Novel Candidate Gene for Chronic Visceral Pain Sheds Light on the Potential Role of Enteric Neurons in the Development of Visceral Hypersensitivity., [RefSeq, PubMed]; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation., [UniProtKB, PubMed]; This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]., [RefSeq]; Vasopressin receptor 1a-mediated negative regulation of B cell receptor signaling., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62464;Q9QYH2", "ec_number_list": "", "go_molecular_function": "GO:0031894 V1A vasopressin receptor binding;GO:0017046 peptide hormone binding;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0002125 maternal aggressive behavior;GO:0007621 negative regulation of female receptivity;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62432-1", "uniprot_id": "SMAD2_MOUSE", "mass": 52266.0, "length": 467, "protein_name": "SMAD family member 2", "gene_name": "Smad2", "organism": "Mouse", "refseq_name": "SMAD family member 2 isoform 1", "refseq_ac": "NP_001239410", "gene_names_uniprotkb": "Smad2; Madh2; Madr2", "gene_names_refseq": "7120426M23Rik; Madh2; Madr2; Smad-2; Smad2; mMad2", "protein_names_uniprotkb": "SMAD family member 2; MAD homolog 2; Mad-related protein 2; Mothers against DPP homolog 2; Mothers against decapentaplegic homolog 2; SMAD 2; mMad2", "protein_names_refseq": "MAD homolog 2; SMAD family member 2 isoform 1; Smad 2; mad-related protein 2; mothers against DPP homolog 2; mothers against decapentaplegic homolog 2", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Loeys-Dietz syndrome 6 (Disease Ontology:DOID:0060964); endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); Lynch syndrome (Disease Ontology:DOID:3883); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:17126); (R-MMU-1181150); (R-MMU-1502540); (R-MMU-2173788); (R-MMU-2173789); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-5689880); (R-MMU-9617828)", "pathway_count": 9, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10681527;10708952;11094085;12370310;12672795;14701940;15221015;15356634;15496141;15630024;17341133;21145499;21383698;21731500;21750661;21949412;22781750;23527246;26495903;27441395;28528544;28870245;29203869;29620144;32535965;33548622;35984892;37828378;8756346;8980228;9328171;9346966", "class_list": "", "function": "Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (PubMed:33548622). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GU18;Q6VP00;Q9D8P6", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0071559 response to transforming growth factor beta;GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0048340 paraxial mesoderm morphogenesis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q62432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D902-1", "uniprot_id": "T2EB_MOUSE", "mass": 33047.0, "length": 292, "protein_name": "General transcription factor IIE subunit 2", "gene_name": "Gtf2e2", "organism": "Mouse", "refseq_name": "general transcription factor IIE subunit 2", "refseq_ac": "NP_001161393", "gene_names_uniprotkb": "Gtf2e2", "gene_names_refseq": "34kDa; C330006J08Rik; Gtf2e2", "protein_names_uniprotkb": "General transcription factor IIE subunit 2; TFIIE-beta; Transcription initiation factor IIE subunit beta", "protein_names_refseq": "TFIIE-beta; general transcription factor II E, polypeptide 2 (beta subunit, 34kD); general transcription factor IIE subunit 2; general transcription factor IIE, polypeptide 2 (beta subunit, 34kD); transcription initiation factor IIE subunit beta", "tax_id": 10090, "disease": "nonphotosensitive trichothiodystrophy 6 (Disease Ontology:DOID:0111872)", "pathway": " (mmu:68153); (R-MMU-674695); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "18299400;19224205;19892989;20173027;20484733;21750661;21952136;23806337;25428506;25605945;27802388;30084848;30779550;31219806;34428180;35820727;37828378", "class_list": "", "function": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5Y7;Q8BTZ2;Q8VE14", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005673 transcription factor TFIIE complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D902-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJG0-1", "uniprot_id": "TACC2_MOUSE", "mass": 124130.0, "length": 1149, "protein_name": "Transforming acidic coiled-coil-containing protein 2", "gene_name": "Tacc2", "organism": "Mouse", "refseq_name": "transforming acidic coiled-coil-containing protein 2 isoform d", "refseq_ac": "NP_001334566", "gene_names_uniprotkb": "Tacc2; MNCb-3527", "gene_names_refseq": "Tacc2; mKIAA4180", "protein_names_uniprotkb": "Transforming acidic coiled-coil-containing protein 2", "protein_names_refseq": "transforming acidic coiled-coil-containing protein 2 isoform d", "tax_id": 10090, "disease": "", "pathway": " (mmu:57752)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15207008;15226440;17242355;17920017;21183079;21750661;31219806;31996486", "class_list": "", "function": "Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity)., [UniProtKB, PubMed, PubMed]; Results suggest that TACC2 is not required for mouse development and normal cell proliferation and is not a tumor suppressor protein., [RefSeq, PubMed]; This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN02;Q811U0;Q8BQD4;Q99KQ6", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005856 cytoskeleton", "go_biological_process": "GO:0008283 cell population proliferation;GO:0021987 cerebral cortex development;GO:0032886 regulation of microtubule-based process;GO:0000226 microtubule cytoskeleton organization;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JJG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62311-1", "uniprot_id": "TAF6_MOUSE", "mass": 72673.0, "length": 678, "protein_name": "Transcription initiation factor TFIID subunit 6", "gene_name": "Taf6", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 6", "refseq_ac": "NP_033341", "gene_names_uniprotkb": "Taf6; Taf2e", "gene_names_refseq": "80kDa; TAF(II)80; TAFII70; Taf2e; Taf6; p80", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 6; TAF(II)70; TAF(II)80; TAFII-70; TAFII-80; TAFII70; TAFII80; Transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID 80 kDa subunit; p80", "protein_names_refseq": "TAF(II)70; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kDa; TAFII-70; TAFII-80; TAFII80; TATA box binding protein (Tbp)-associated factor, RNA polymerase II, E; transcription initiation factor TFIID 70 kDa subunit; transcription initiation factor TFIID 80 kDa subunit; transcription initiation factor TFIID subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:21343); (R-MMU-674695); (R-MMU-6804756); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "21183079;21606357;21750661;21952136;22517741;24129315;25428506;29125738;30084848;31219806;32782141;32848054;34428180;35820727;35822049;36852467;40021952;40885482;40997131;7665100", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0017162 aryl hydrocarbon receptor binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0071339 MLL1 complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q62311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D032-1", "uniprot_id": "SSBP3_MOUSE", "mass": 40421.0, "length": 388, "protein_name": "Single-stranded DNA-binding protein 3", "gene_name": "Ssbp3", "organism": "Mouse", "refseq_name": "single-stranded DNA-binding protein 3 isoform a", "refseq_ac": "NP_076161", "gene_names_uniprotkb": "Ssbp3; Last; Ssdp1", "gene_names_refseq": "2610021L12Rik; 2610200M23Rik; 5730488C10Rik; LAST; SSDP1; Ssbp3", "protein_names_uniprotkb": "Single-stranded DNA-binding protein 3; Lck-associated signal transducer; Sequence-specific single-stranded-DNA-binding protein", "protein_names_refseq": "Lck-associated signal transducer; sequence-specific single-stranded-DNA-binding protein; single-stranded DNA-binding protein 3 isoform a", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:72475)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12479417;12642495;15857913;17242355;21183079;21750661;24129315;26495868;27236334;28528544;32782141;32848054;34428180;36852467;37536498;40885482", "class_list": "", "function": "May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region., [UniProtKB]; SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic beta-Cell Target Genes, [RefSeq, PubMed]; Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells. Publication Status: Online-Only, [RefSeq, PubMed]; Ssdp1 regulates the development of late head organizer tissues and body growth by functioning as an essential activator component of a Lim1 complex through interaction with Ldb1., [RefSeq, PubMed]; The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity., [RefSeq, PubMed]; This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in the differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q99LC6;Q9EQP3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060323 head morphogenesis;GO:0021501 prechordal plate formation;GO:0021547 midbrain-hindbrain boundary initiation;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9D032-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHY8-1", "uniprot_id": "SNX14_MOUSE", "mass": 111865.0, "length": 964, "protein_name": "Sorting nexin-14", "gene_name": "Snx14", "organism": "Mouse", "refseq_name": "sorting nexin-14 isoform 1", "refseq_ac": "NP_766514", "gene_names_uniprotkb": "Snx14", "gene_names_refseq": "B830022K16; C330035N22Rik; Snx14; YR-14", "protein_names_uniprotkb": "Sorting nexin-14", "protein_names_refseq": "sorting nexin-14 isoform 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 20 (Disease Ontology:DOID:0080066)", "pathway": " (mmu:244962)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21750661;21952136;24859318;25795301;30779550;31219806;32792680;34203471;34428180;35820727;36210013;37828378", "class_list": "", "function": "Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (PubMed:24859318). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity)., [UniProtKB, PubMed, UniProtKB]; SNX14 is a dual endogenous negative regulator in 5-HT6R-mediated signaling pathway., [RefSeq, PubMed]; These data reveal a role for monoallelic Snx14 expression in maintaining normal neuronal excitability and synaptic transmission. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V2Q4;G3UWA3", "ec_number_list": "", "go_molecular_function": "GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030425 dendrite;GO:0045202 synapse;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0015031 protein transport;GO:0099170 postsynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BHY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q812A2-1", "uniprot_id": "SRGP3_MOUSE", "mass": 124420.0, "length": 1099, "protein_name": "SLIT-ROBO Rho GTPase-activating protein 3", "gene_name": "Srgap3", "organism": "Mouse", "refseq_name": "SLIT-ROBO Rho GTPase-activating protein 3", "refseq_ac": "NP_536696", "gene_names_uniprotkb": "Srgap3; Arhgap14; Kiaa0411; Srgap2", "gene_names_refseq": "Arhgap14; D130026O08Rik; Gbi; MEGAP; Srgap3; WRP; mKIAA0411", "protein_names_uniprotkb": "SLIT-ROBO Rho GTPase-activating protein 3; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein; WRP; srGAP3", "protein_names_refseq": "SLIT-ROBO Rho GTPase activating protein 2; SLIT-ROBO Rho GTPase-activating protein 3; WAVE-associated Rac GTPase-activating protein; brain stress early protein Gbi; rho GTPase-activating protein 14; srGAP2", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:259302); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12447388;15345747;17114649;21183079;21750661;25605945;26104135;26499801;27184948;31219806;33300544;34428180;35820727;36210013", "class_list": "", "function": "GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity)., [UniProtKB]; SrGAP3 plays a role in neurodevelopmental disorders., [RefSeq, PubMed]; This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80U09;Q8BKP4;Q8BLD0;Q925I2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030336 negative regulation of cell migration;GO:0051963 regulation of synapse assembly;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q812A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1I3-1", "uniprot_id": "SPP24_MOUSE", "mass": 23136.0, "length": 203, "protein_name": "Secreted phosphoprotein 24", "gene_name": "Spp2", "organism": "Mouse", "refseq_name": "secreted phosphoprotein 24 precursor", "refseq_ac": "NP_083545", "gene_names_uniprotkb": "Spp2; Spp24", "gene_names_refseq": "0610038O04Rik; Spp2; pp-24; spp24", "protein_names_uniprotkb": "Secreted phosphoprotein 24; Secreted phosphoprotein 2; Spp-24", "protein_names_refseq": "secreted phosphoprotein 2, 24kDa; secreted phosphoprotein 24 precursor; secreted phosphoprotein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:75396); (R-MMU-114608); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17242355;20162696;21183079;21750661;34428180", "class_list": "", "function": "Could coordinate an aspect of bone turnover., [UniProtKB, UniProtKB, UniProtKB]; Proteolytic processing of spp24 affects the interaction of this protein with BMP-2 and this affects the function of the protein, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCG1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046849 bone remodeling;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K1I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4VBD2-1", "uniprot_id": "TAPT1_MOUSE", "mass": 63894.0, "length": 564, "protein_name": "Transmembrane anterior posterior transformation protein 1", "gene_name": "Tapt1", "organism": "Mouse", "refseq_name": "transmembrane anterior posterior transformation protein 1", "refseq_ac": "NP_776125", "gene_names_uniprotkb": "Tapt1", "gene_names_refseq": "4932414K18Rik; Tapt1", "protein_names_uniprotkb": "Transmembrane anterior posterior transformation protein 1", "protein_names_refseq": "transmembrane anterior posterior transformation protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231225)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17151244;21183079;21750661;34428180;36370851", "class_list": "", "function": "Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; TAPT1 is a downstream effector of HOXC8 that may act by transducing or transmitting extracellular information required for axial skeletal patterning during development., [RefSeq, PubMed]; Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5. Erratum:[J Biol Chem. 2023 Jul;299(7):104957. doi: 10.1016/j.jbc.2023.104957. PMID: 37393648], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDI4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0036064 ciliary basal body", "go_biological_process": "GO:1903012 positive regulation of bone development;GO:0014032 neural crest cell development;GO:0001503 ossification;GO:0030030 cell projection organization;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4VBD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZX7-1", "uniprot_id": "SRR_MOUSE", "mass": 36359.0, "length": 339, "protein_name": "Serine racemase", "gene_name": "Srr", "organism": "Mouse", "refseq_name": "serine racemase isoform 1", "refseq_ac": "NP_001156783", "gene_names_uniprotkb": "Srr", "gene_names_refseq": "M100034; Rgsc34; Srr; Srs", "protein_names_uniprotkb": "Serine racemase; 4.3.1.17; 4.3.1.18; 5.1.1.18; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase", "protein_names_refseq": "D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; serine racemase isoform 1", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:27364); (R-MMU-977347)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10557334;12021263;12393813;12515328;15536068;17293453;20493854;21183079;21750661;33300544;35915065;40259883", "class_list": "", "function": "Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine., [UniProtKB, UniProtKB]; Direct calcium binding results in activation in brain, [RefSeq, PubMed]; Pyridoxal-5'-phosphate (PLP)-dependent enzyme that catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. In addition to racemization, has dehydratase activity towards both L-serine and D-serine, a two-step reaction in which the hydroxyl group of serine is eliminated to produce aminoacrylate (2-aminoprop-2-enoate), and then the aminoacrylate (an unstable intermediate) is deaminated by nonenzymatic hydrolysis to produce pyruvate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q401M7;Q5SWE4;Q5SWE5;Q5SWE7;Q8BT19;Q8CD11", "ec_number_list": "4.3.1.17;4.3.1.19;5.1.1.3;4.3.1.18;5.1.1.18", "go_molecular_function": "GO:0008721 D-serine ammonia-lyase activity;GO:0018114 threonine racemase activity;GO:0030378 serine racemase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0045177 apical part of cell", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:1901986 response to ketamine;GO:0070179 D-serine biosynthetic process;GO:0070178 D-serine metabolic process;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9QZX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QWV9-1", "uniprot_id": "CCNT1_MOUSE", "mass": 80598.0, "length": 724, "protein_name": "Cyclin-T1", "gene_name": "Ccnt1", "organism": "Mouse", "refseq_name": "cyclin-T1 isoform 1", "refseq_ac": "NP_033963", "gene_names_uniprotkb": "Ccnt1", "gene_names_refseq": "2810478G24Rik; Ccnt1; CycT1", "protein_names_uniprotkb": "Cyclin-T1; CycT1; Cyclin-T", "protein_names_refseq": "cyclin-T1 isoform 1; cyclin-T", "tax_id": 10090, "disease": "", "pathway": " (mmu:12455); (R-MMU-112382); (R-MMU-2173796); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6807505); (R-MMU-75955); (R-MMU-9018519)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10329126;18250455;20484733;21750661;25428506;27292648;30084848;30209133;31219806;31599954;34428180;40997131;9832504;9843510;9990016", "class_list": "", "function": "CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have opposing roles in CHOP expression and chronic kidney disease -induced vascular calcification., [RefSeq, PubMed]; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0G4;Q9Z0U7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0000976 transcription cis-regulatory region binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008024 cyclin/CDK positive transcription elongation factor complex;GO:0070691 P-TEFb complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0043923 host-mediated activation of viral transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9QWV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60737-1", "uniprot_id": "CSK21_MOUSE", "mass": 45134.0, "length": 391, "protein_name": "Casein kinase II subunit alpha", "gene_name": "Csnk2a1", "organism": "Mouse", "refseq_name": "casein kinase II subunit alpha isoform 1", "refseq_ac": "NP_031814", "gene_names_uniprotkb": "Csnk2a1; Ckiia", "gene_names_refseq": "CK II alpha; CK2; Csnk2a1-rs4; Csnk2a1", "protein_names_uniprotkb": "Casein kinase II subunit alpha; 2.7.11.1; CK II alpha", "protein_names_refseq": "casein kinase II subunit alpha isoform 1; casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide; casein kinase II, alpha 1 related sequence 4", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:12995); (R-MMU-1483191); (R-MMU-201688); (R-MMU-2514853); (R-MMU-445144); (R-MMU-6804756); (R-MMU-6814122); (R-MMU-8934903); (R-MMU-8939243); (R-MMU-8948751); (R-MMU-9768727); (R-MMU-9929491)", "pathway_count": 12, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10806215;17954558;18467326;19923321;21750661;31219806;33300544;34428180;36210013;36306106;40997131;7846532", "class_list": "", "function": "Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]., [RefSeq]; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0X4", "ec_number_list": "2.7.11.1;2.7.11.25;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.3.2.27;2.7.10.2;2.7.11.-;2.7.11.4;2.3.2.-;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.1.3.53;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:1905818 regulation of chromosome separation;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q60737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C8S3-1", "uniprot_id": "T150C_MOUSE", "mass": 27759.0, "length": 249, "protein_name": "Transmembrane protein 150C", "gene_name": "Tmem150c", "organism": "Mouse", "refseq_name": "transmembrane protein 150C isoform 1", "refseq_ac": "NP_878261", "gene_names_uniprotkb": "Tmem150c; Ttn3", "gene_names_refseq": "Tmem150c", "protein_names_uniprotkb": "Transmembrane protein 150C; Tentonin 3", "protein_names_refseq": "tentonin 3; transmembrane protein 150C isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231503)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;27321926;28426961;28426962;32484458;34428180;34852221;36256908", "class_list": "", "function": "Lack of evidence for participation of TMEM150C in sensory mechanotransduction., [RefSeq, PubMed]; Nonselective cationic channel with high permeability to Ca(2+) (PubMed:27321926). Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception (PubMed:27321926)., [UniProtKB, PubMed]; TTN3 appears to be a component of a mechanosensitive channel with a slow inactivation rate and contributes to motor coordination. Identification of this gene advances our understanding of the various types of mechanosensations, including proprioception, [RefSeq, PubMed]; Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic beta-cells., [RefSeq, PubMed]; Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YVG3;Q3TL78;Q8K117", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0140135 mechanosensitive monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0071260 cellular response to mechanical stimulus;GO:0019230 proprioception", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C8S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57716-1", "uniprot_id": "NICA_MOUSE", "mass": 78492.0, "length": 708, "protein_name": "Nicastrin", "gene_name": "Ncstn", "organism": "Mouse", "refseq_name": "nicastrin precursor", "refseq_ac": "NP_067620", "gene_names_uniprotkb": "Ncstn", "gene_names_refseq": "9430068N19Rik; Aph2; D1Dau13e; Kiaa0253; Ncstn; Nct; mKIAA0253", "protein_names_uniprotkb": "Nicastrin", "protein_names_refseq": "nicastrin precursor", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); vitiligo (Disease Ontology:DOID:12306); alcohol use disorder (Disease Ontology:DOID:1574); hidradenitis suppurativa (Disease Ontology:DOID:2280); schizophrenia (Disease Ontology:DOID:5419); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:59287); (R-MMU-1251985); (R-MMU-193692); (R-MMU-205043); (R-MMU-3928665); (R-MMU-6798695); (R-MMU-9013507); (R-MMU-9017802); (R-MMU-9839383)", "pathway_count": 9, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10993067;12716934;16075062;19349973;21750661;25428506;29187734;30084848;30779550;30899004;31219806;31599954;32152506;33300544;34428180;35820727;35843211;36654118;39627609", "class_list": "", "function": "A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway., [RefSeq, PubMed]; Effects of NCSTN Mutation on Hair Follicle Components in Mice., [RefSeq, PubMed]; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 7, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "E9QLZ6;Q8VE20", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding;GO:0070851 growth factor receptor binding;GO:0008233 peptidase activity;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0007611 learning or memory;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P57716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20664-1", "uniprot_id": "PRI1_MOUSE", "mass": 49295.0, "length": 417, "protein_name": "DNA primase small subunit", "gene_name": "Prim1", "organism": "Mouse", "refseq_name": "DNA primase small subunit", "refseq_ac": "NP_032947", "gene_names_uniprotkb": "Prim1", "gene_names_refseq": "Prim1", "protein_names_uniprotkb": "DNA primase small subunit; 2.7.7.102; DNA primase 49 kDa subunit; p49", "protein_names_refseq": "DNA primase 49 kDa subunit; DNA primase small subunit; p49", "tax_id": 10090, "disease": "", "pathway": " (mmu:19075); (R-MMU-113501); (R-MMU-174411); (R-MMU-174430); (R-MMU-68952); (R-MMU-68962); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "25605945;2925677;31219806;8026492;8253737;8463324", "class_list": "", "function": "Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:8026492, PubMed:8253737). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:8253737). Can add both ribo- and deoxynucleotides during elongation of the primers (PubMed:8253737). Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers) (By similarity). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end (By similarity). Binds single stranded DNA (PubMed:8253737)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.102;3.6.4.12;2.7.7.7;3.1.-.-;3.1.11.-;2.7.11.22;5.6.2.4;2.7.11.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0032553 ribonucleotide binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20664-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5A0-1", "uniprot_id": "SPESP_MOUSE", "mass": 44702.0, "length": 399, "protein_name": "Sperm equatorial segment protein 1", "gene_name": "Spesp1", "organism": "Mouse", "refseq_name": "sperm equatorial segment protein 1 precursor", "refseq_ac": "NP_079997", "gene_names_uniprotkb": "Spesp1", "gene_names_refseq": "4921508E09Rik; Spesp1", "protein_names_uniprotkb": "Sperm equatorial segment protein 1", "protein_names_refseq": "sperm equatorial segment protein 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66712)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20375058;25761597;27539077;38764260", "class_list": "", "function": "Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice., [RefSeq, PubMed]; Involved in fertilization ability of sperm., [UniProtKB, PubMed, PubMed]; SPESP1 is necessary to produce the fully 'fusion competent' sperm., [RefSeq, PubMed]; The present study identified SPESP1 in the acrosome as the primary binding target of Peanut agglutinin (PNA) in the mouse testis. Further defining the specific lectin-glycoprotein relationships in individual cells will enhance the value of lectin histochemistry., [RefSeq, PubMed]; These findings are consistent with the hypothesis that SPSPESP1 undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5X8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0001669 acrosomal vesicle;GO:0072686 mitotic spindle", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566 fertilization;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D5A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L88-1", "uniprot_id": "SNTB1_MOUSE", "mass": 58081.0, "length": 537, "protein_name": "Beta-1-syntrophin", "gene_name": "Sntb1", "organism": "Mouse", "refseq_name": "beta-1-syntrophin", "refseq_ac": "NP_057876", "gene_names_uniprotkb": "Sntb1; Snt2b1", "gene_names_refseq": "Sntb1", "protein_names_uniprotkb": "Beta-1-syntrophin; 59 kDa dystrophin-associated protein A1 basic component 1; DAPA1B; Syntrophin-2", "protein_names_refseq": "59 kDa dystrophin-associated protein A1 basic component 1; 59-1 DAP; DAPA1B; beta-1-syntrophin; beta1-Syntrophin; syntrophin-2", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:20649); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10893187;17242355;21183079;30803043;32178707;33872576;9214383;9412493", "class_list": "", "function": "Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex., [UniProtKB]; Functional specialization of retinal Muller cell endfeet depends on an interplay between two syntrophin isoforms. Publication Status: Online-Only, [RefSeq, PubMed]; Orchestrating aquaporin-4 and connexin-43 expression in brain: Differential roles of alpha1- and beta1-syntrophin., [RefSeq, PubMed]; Targeted disruption of Beta1-syntrophin causes a loss of Kir4.1 from Muller cell endfeet in the retina., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35925", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005198 structural molecule activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0045202 synapse;GO:0042383 sarcolemma;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99L88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJF9-1", "uniprot_id": "SPP2A_MOUSE", "mass": 58129.0, "length": 523, "protein_name": "Signal peptide peptidase-like 2A", "gene_name": "Sppl2a", "organism": "Mouse", "refseq_name": "signal peptide peptidase-like 2A precursor", "refseq_ac": "NP_075709", "gene_names_uniprotkb": "Sppl2a; Imp3; MNCb-3763; Psl2", "gene_names_refseq": "2010106G01Rik; C130089K23Rik; Sppl2a", "protein_names_uniprotkb": "Signal peptide peptidase-like 2A; 3.4.23.-; IMP-3; Intramembrane protease 3; Presenilin-like protein 2; SPP-like 2A; SPPL2a", "protein_names_refseq": "IMP-3; SPP-like 2A protein; intramembrane protease 3; presenilin-like protein 2; protein SPPL2a; signal peptide peptidase-like 2A precursor", "tax_id": 10090, "disease": "immunodeficiency 86 (Disease Ontology:DOID:0061056)", "pathway": " (mmu:66552); (R-MMU-5357905)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;21750661;21896273;23267013;23267015;23267016;23426979;25428506;30084848;30127434;30779550;30819724;31219806;33239420;34428180;36047592", "class_list": "", "function": "B cell survival and dendritic cells function requires SPPL2A., [RefSeq, PubMed]; Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes., [RefSeq, PubMed]; Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells., [RefSeq, PubMed]; Intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts., [RefSeq, PubMed]; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system. Plays a role in the regulation of innate and adaptive immunity., [UniProtKB, PubMed, PubMed]; SPPL2a/b negatively regulates LOX-1 signaling and atherosclerosis., [RefSeq, PubMed]; Sppl2a is required for B cell and dendritic cells development and survival., [RefSeq, PubMed]; Sppl2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain., [RefSeq, PubMed]; The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9409, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AI51;Q8R354", "ec_number_list": "3.4.23.-", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0050776 regulation of immune response;GO:0031293 membrane protein intracellular domain proteolysis;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9JJF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCF9-1", "uniprot_id": "SSRG_MOUSE", "mass": 21064.0, "length": 185, "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "Ssr3", "organism": "Mouse", "refseq_name": "translocon-associated protein subunit gamma", "refseq_ac": "NP_080431", "gene_names_uniprotkb": "Ssr3", "gene_names_refseq": "0610038P07Rik; Ssr3; TRAPG", "protein_names_uniprotkb": "Translocon-associated protein subunit gamma; SSR-gamma; Signal sequence receptor subunit gamma; TRAP-gamma", "protein_names_refseq": "SSR-gamma; TRAP-gamma; signal sequence receptor subunit gamma; translocon-associated protein gamma; translocon-associated protein subunit gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:67437)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "17242355;18250455;18299400;19144319;20173027;21183079;21246656;21952136;25428507;31219806;34428180;35820727;36210013;37453647;37828378", "class_list": "", "function": "Results suggest that Trap-gamma appears to be required for vascular network formation in murine placental development., [RefSeq, PubMed]; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0Z8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9DCF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58871-1", "uniprot_id": "TB182_MOUSE", "mass": 181825.0, "length": 1720, "protein_name": "182 kDa tankyrase-1-binding protein", "gene_name": "Tnks1bp1", "organism": "Mouse", "refseq_name": "182 kDa tankyrase-1-binding protein", "refseq_ac": "NP_001074729", "gene_names_uniprotkb": "Tnks1bp1; Kiaa1741; Tab182", "gene_names_refseq": "Cnot12; Tab182; Tnks1bp1; mKIAA1741", "protein_names_uniprotkb": "182 kDa tankyrase-1-binding protein", "protein_names_refseq": "182 kDa tankyrase-1-binding protein; tankyrase 1 binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228140); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;15345747;17242355;18630941;19131326;21158410;21183079;21540332;21750661;22517741;22645316;25153642;26192747;28135057;28528544;29562282;30059200;32782141;32848054;34678516;35822049;36852467;39113018;40021952;40885482", "class_list": "", "function": "TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 65, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2BH84;Q6ZPI8", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0071532 ankyrin repeat binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005912 adherens junction", "go_biological_process": "GO:0006302 double-strand break repair;GO:0071479 cellular response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P58871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZT9-1", "uniprot_id": "TBC30_MOUSE", "mass": 84893.0, "length": 766, "protein_name": "TBC1 domain family member 30", "gene_name": "Tbc1d30", "organism": "Mouse", "refseq_name": "TBC1 domain family member 30 isoform 1", "refseq_ac": "NP_083333", "gene_names_uniprotkb": "Tbc1d30; Kiaa0984", "gene_names_refseq": "4930505D03Rik; 9530013E20Rik; Tbc1d30", "protein_names_uniprotkb": "TBC1 domain family member 30", "protein_names_refseq": "TBC1 domain family member 30 isoform 1; TBC1 domain family member 30-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:74694)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "May act as a GTPase-activating protein for Rab family protein(s)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHP9;Q6AXF5;Q6PCX1;Q8C8T3", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016604 nuclear body;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q69ZT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64336-1", "uniprot_id": "TBR1_MOUSE", "mass": 73940.0, "length": 681, "protein_name": "T-box brain protein 1", "gene_name": "Tbr1", "organism": "Mouse", "refseq_name": "T-box brain protein 1 isoform 1", "refseq_ac": "NP_033348", "gene_names_uniprotkb": "Tbr1", "gene_names_refseq": "Tbr1", "protein_names_uniprotkb": "T-box brain protein 1; T-brain-1; TBR-1; TES-56", "protein_names_refseq": "T-box brain gene 1; T-box brain protein 1 isoform 1; T-box brain protein 1; T-brain-1; TBR-1; TES-56", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:21375)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;11239428;15066269;16452087;21183079;21285371;21750661;22517741;22645316;22826440;35822049;40885482;7619531;9883721", "class_list": "", "function": "Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:11239428, PubMed:21285371, PubMed:9883721). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (PubMed:21285371)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSY9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0010092 specification of animal organ identity;GO:1902667 regulation of axon guidance;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q64336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPZ6-1", "uniprot_id": "TBX18_MOUSE", "mass": 65464.0, "length": 613, "protein_name": "T-box transcription factor TBX18", "gene_name": "Tbx18", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX18", "refseq_ac": "NP_076303", "gene_names_uniprotkb": "Tbx18", "gene_names_refseq": "2810012F10Rik; 2810404D13Rik; Tbx18", "protein_names_uniprotkb": "T-box transcription factor TBX18; T-box protein 18", "protein_names_refseq": "T-box protein 18; T-box transcription factor TBX18", "tax_id": 10090, "disease": "congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207)", "pathway": " (mmu:76365)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11118889;12663494;15155583;16511601;17584735;18644785;19096026;21750661;24016759;26235987;34428180", "class_list": "", "function": "Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart, the coronary vessels, the ureter, and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of Tbx18 as a candidate gene for osteosarcoma, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090571 RNA polymerase II transcription repressor complex", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0001708 cell fate specification;GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development;GO:0060931 sinoatrial node cell development;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EPZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56695-1", "uniprot_id": "WFS1_MOUSE", "mass": 100579.0, "length": 890, "protein_name": "Wolframin", "gene_name": "Wfs1", "organism": "Mouse", "refseq_name": "wolframin", "refseq_ac": "NP_035846", "gene_names_uniprotkb": "Wfs1", "gene_names_refseq": "Wfs1; wolframin", "protein_names_uniprotkb": "Wolframin", "protein_names_refseq": "Wolfram syndrome 1 homolog; Wolfram syndrome 1 protein homolog; wolframin", "tax_id": 10090, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal dominant Wolfram syndrome (Disease Ontology:DOID:0080584); cataract 41 (Disease Ontology:DOID:0110241); autosomal dominant nonsyndromic deafness 6 (Disease Ontology:DOID:0110584); Wolfram syndrome 1 (Disease Ontology:DOID:0110629); optic atrophy 1 (Disease Ontology:DOID:0111441); sensorineural hearing loss (Disease Ontology:DOID:10003); glucose intolerance (Disease Ontology:DOID:10603); Wolfram syndrome (Disease Ontology:DOID:10632); post-traumatic stress disorder (Disease Ontology:DOID:2055); optic atrophy (Disease Ontology:DOID:5723); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:22393); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12649740;15056606;15522226;17114649;21183079;21750661;23531866;25428506;25605945;30899004;33300544;36288343;40885482;9771706;9817917", "class_list": "", "function": "May play a role in inner ear ion homeostasis as maintained by the canalicular reticulum, [RefSeq, PubMed]; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of WFS1 in the etiology of Wolfram syndrome is examined in WFS1 mutant mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z276", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0030141 secretory granule;GO:0030425 dendrite;GO:0005789 endoplasmic reticulum membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:1903892 negative regulation of ATF6-mediated unfolded protein response;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003091 renal water homeostasis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P56695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97765-1", "uniprot_id": "WBP2_MOUSE", "mass": 28032.0, "length": 261, "protein_name": "WW domain-binding protein 2", "gene_name": "Wbp2", "organism": "Mouse", "refseq_name": "WW domain-binding protein 2 isoform 1", "refseq_ac": "NP_058548", "gene_names_uniprotkb": "Wbp2", "gene_names_refseq": "Wbp2", "protein_names_uniprotkb": "WW domain-binding protein 2; WBP-2", "protein_names_refseq": "WBP-2; WW domain-binding protein 2 isoform 1", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 107 (Disease Ontology:DOID:0080262)", "pathway": " (mmu:22378)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11042109;16075062;21642474;22645316;25428506;26495903;26881968;28011936;28135057;33658485;34428180;34678516;37507081;7644498", "class_list": "", "function": "Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Synergizes with YAP1 to enhance PGR activity (By similarity). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (PubMed:26881968)., [UniProtKB, PubMed, UniProtKB]; This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk., [RefSeq, PubMed]; WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKbeta1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2A860", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032570 response to progesterone;GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P97765-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXJ0-1", "uniprot_id": "WWC2_MOUSE", "mass": 132620.0, "length": 1187, "protein_name": "Protein WWC2", "gene_name": "Wwc2", "organism": "Mouse", "refseq_name": "protein WWC2", "refseq_ac": "NP_598552", "gene_names_uniprotkb": "Wwc2; D8Ertd594e; MNCb-4173", "gene_names_refseq": "5330431C14Rik; D8Ertd594e; Wwc2", "protein_names_uniprotkb": "Protein WWC2; WW domain-containing protein 2", "protein_names_refseq": "WW domain-containing protein 2; protein WWC2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52357)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;22517741;22645316;31219806;32782141;33483469;34070186;34678516;36852467;37086090;40021952;40885482", "class_list": "", "function": "Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway., [UniProtKB, UniProtKB]; The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; WWC2 expression in the testis: Implications for spermatogenesis and male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGG4;Q3UH10;Q7TMY1;Q8CE61;Q9JJ63", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019900 kinase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0035330 regulation of hippo signaling;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q6NXJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R5L3-1", "uniprot_id": "VPS39_MOUSE", "mass": 101693.0, "length": 886, "protein_name": "Vam6/Vps39-like protein", "gene_name": "Vps39", "organism": "Mouse", "refseq_name": "vam6/Vps39-like protein isoform 1", "refseq_ac": "NP_671495", "gene_names_uniprotkb": "Vps39; Pldn; Vam6", "gene_names_refseq": "A230065P22Rik; Vam6P; Vam6; Vps39; mVam6", "protein_names_uniprotkb": "Vam6/Vps39-like protein", "protein_names_refseq": "vacuolar protein sorting 39; vam6/Vps39-like protein isoform 1; vam6/Vps39-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:269338)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15110766;20961651;21411634;25428506;31219806;34428180;35452878;36741382", "class_list": "", "function": "Antibodies to VAMP and SNAP inhibited sperm-zona pellucida interaction, suggesting their possible involvement in sperm membrane vesiculation., [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity)., [UniProtKB, UniProtKB]; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription (By similarity)., [UniProtKB, UniProtKB]; SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells., [RefSeq, PubMed]; Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922I3", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0097576 vacuole fusion;GO:0006886 intracellular protein transport;GO:0006914 autophagy;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R5L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBR1-1", "uniprot_id": "XRN2_MOUSE", "mass": 108687.0, "length": 951, "protein_name": "5'-3' exoribonuclease 2", "gene_name": "Xrn2", "organism": "Mouse", "refseq_name": "5'-3' exoribonuclease 2 isoform 1", "refseq_ac": "NP_036047", "gene_names_uniprotkb": "Xrn2; Dhm1", "gene_names_refseq": "Xrn2", "protein_names_uniprotkb": "5'-3' exoribonuclease 2; 3.1.13.-; Protein Dhm1", "protein_names_refseq": "5'-3' exoribonuclease 2 isoform 1; protein Dhm1", "tax_id": 10090, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); leiomyosarcoma (Disease Ontology:DOID:1967)", "pathway": " (mmu:24128); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "17242355;18630941;19131326;19144319;19915612;21183079;22645316;23806337;24129315;25153642;25428506;27331609;28528544;30084848;34428180;36084651;36495875;37697435;39627609;7885830", "class_list": "", "function": "Genetic variants regulating Xrn2 expression in cis are determinants of spontaneous lung tumor susceptibility in mice and have genetic equivalents in lung cancer susceptibility in human beings., [RefSeq, PubMed]; Nkx2-5 genetically interacts with Xrn2 because Nkx2-5(+/-)Xrn2(+/-), but neither Nkx2-5(+/-)nor Xrn2(+/-), newborns exhibited a defect in ventricular septum formation, suggesting that the association between Nkx2-5 and Xrn2 is essential for heart development. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity)., [UniProtKB, UniProtKB]; RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2., [RefSeq, PubMed]; RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI26;Q3TKF2;Q3UZT9;Q61489;Q99KS7", "ec_number_list": "2.1.1.-;3.6.4.13;3.4.19.12;3.4.21.53;3.1.13.-;5.2.1.8", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0001147 transcription termination site sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016235 aggresome", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9DBR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZX4-1", "uniprot_id": "SPF45_MOUSE", "mass": 45304.0, "length": 405, "protein_name": "Splicing factor 45", "gene_name": "Rbm17", "organism": "Mouse", "refseq_name": "splicing factor 45 isoform 1", "refseq_ac": "NP_690037", "gene_names_uniprotkb": "Rbm17; Spf45", "gene_names_refseq": "2700027J02Rik; Rbm17", "protein_names_uniprotkb": "Splicing factor 45; 45 kDa-splicing factor; RNA-binding motif protein 17", "protein_names_refseq": "45 kDa-splicing factor; splicing factor 45 isoform 1; splicing factor 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:76938); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17242355;19144319;21183079;21750661;21835928;23806337;28007900;9731529", "class_list": "", "function": "Dephosphorylation of pS776-ATXN1 by PP2A regulates the interaction of ATXN1 with the splicing factors RBM17 and U2AF65 Erratum:[J Biol Chem. 2013 Mar 1;288(9):6590], [RefSeq, PubMed]; Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites (By similarity)., [UniProtKB]; We found a significant overlap in genes that undergo both RBM17- and TDP-43-dependent cryptic splicing repression, many of which are associated with survival. We propose that repression of cryptic splicing by RBPs is critical for neuronal health and survival, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AP41;O75939", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8JZX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRB0-1", "uniprot_id": "SNX24_MOUSE", "mass": 19653.0, "length": 169, "protein_name": "Sorting nexin-24", "gene_name": "Snx24", "organism": "Mouse", "refseq_name": "sorting nexin-24", "refseq_ac": "NP_083670", "gene_names_uniprotkb": "Snx24", "gene_names_refseq": "2810011K15Rik; 5730433I16Rik; Snx24", "protein_names_uniprotkb": "Sorting nexin-24", "protein_names_refseq": "sorting nexin-24", "tax_id": 10090, "disease": "", "pathway": " (mmu:69226)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;21183079", "class_list": "", "function": "May be involved in several stages of intracellular trafficking., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CRB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0M3U1B0-1", "uniprot_id": "SYC2L_MOUSE", "mass": 96055.0, "length": 842, "protein_name": "Synaptonemal complex protein 2-like", "gene_name": "Sycp2l", "organism": "Mouse", "refseq_name": "synaptonemal complex protein 2-like", "refseq_ac": "NP_001311454", "gene_names_uniprotkb": "Sycp2l", "gene_names_refseq": "EG621792; Gm268; Gm40956; Sycp2l", "protein_names_uniprotkb": "Synaptonemal complex protein 2-like; SCP-2-like", "protein_names_refseq": "SCP-2-like; synaptonemal complex protein 2-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:637277)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26362258", "class_list": "", "function": "Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YWV8;F6RWL8;F6ZC70", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000779 condensed chromosome, centromeric region;GO:0000800 lateral element", "go_biological_process": "GO:0043069 negative regulation of programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0M3U1B0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCS1-1", "uniprot_id": "T176A_MOUSE", "mass": 26596.0, "length": 244, "protein_name": "Transmembrane protein 176A", "gene_name": "Tmem176a", "organism": "Mouse", "refseq_name": "transmembrane protein 176A", "refseq_ac": "NP_001091741", "gene_names_uniprotkb": "Tmem176a; Gs188; Keg2", "gene_names_refseq": "0610011I04Rik; Keg2; Tmem176a", "protein_names_uniprotkb": "Transmembrane protein 176A; Gene signature 188; Kidney-expressed gene 2 protein", "protein_names_refseq": "gene signature 188; kidney expressed gene 2; kidney-expressed gene 2 protein; transmembrane protein 176A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66058)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11967007;20501748;21183079;21750661;27009467;34233909", "class_list": "", "function": "Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells., [RefSeq, PubMed]; Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that Tmem176B and Tmem176A associate to form multimers and restrain dendritic cell maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCE2;Q8BV92;Q8K4T0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:2001199 negative regulation of dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMJ2-1", "uniprot_id": "SYLC_MOUSE", "mass": 134192.0, "length": 1178, "protein_name": "Leucine--tRNA ligase, cytoplasmic", "gene_name": "Lars1", "organism": "Mouse", "refseq_name": "leucine--tRNA ligase, cytoplasmic", "refseq_ac": "NP_598898", "gene_names_uniprotkb": "Lars1; Lars", "gene_names_refseq": "2310045K21Rik; 3110009L02Rik; Lars1; Lars; leuRS", "protein_names_uniprotkb": "Leucine--tRNA ligase, cytoplasmic; 6.1.1.4; LeuRS; Leucyl-tRNA synthetase", "protein_names_refseq": "leucine--tRNA ligase, cytoplasmic; leucyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "infantile liver failure syndrome 1 (Disease Ontology:DOID:0080717)", "pathway": " (mmu:107045); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "19892989;21750661;22645316;23806337;28528544;30905780;30985292;31219806;31780625;34428180;34887587;36210013;38762116;39627609", "class_list": "", "function": "Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing)., [UniProtKB, UniProtKB]; High LARS expression is associated with abdominal aortic aneurysm., [RefSeq, PubMed]; Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy., [RefSeq, PubMed]; Leucyl-tRNA synthetase has a nontranslational function in regulating myogenic differentiation and skeletal muscle regeneration Publication Status: Online-Only, [RefSeq, PubMed]; This study provides evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKW9", "ec_number_list": "2.7.10.1;2.7.11.24;6.1.1.10;6.1.1.4;6.1.1.18;6.1.1.5;6.1.1.12;2.7.7.-;6.1.1.6;6.1.1.19", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004823 leucine-tRNA ligase activity;GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0004819 glutamine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005764 lysosome;GO:0012505 endomembrane system", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006429 leucyl-tRNA aminoacylation;GO:0032008 positive regulation of TOR signaling;GO:0034198 cellular response to amino acid starvation;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BMJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PV87-1", "uniprot_id": "TALD3_MOUSE", "mass": 166721.0, "length": 1520, "protein_name": "Protein TALPID3", "gene_name": "2700049A03Rik; Talpid3", "organism": "Mouse", "refseq_name": "protein TALPID3 isoform 1", "refseq_ac": "NP_001156850", "gene_names_uniprotkb": "2700049A03Rik; Talpid3", "gene_names_refseq": "2700049A03Rik; Ta3; Talpid3; mKIAA0586", "protein_names_uniprotkb": "Protein TALPID3", "protein_names_refseq": "protein TALPID3 isoform 1; protein TALPID3", "tax_id": 10090, "disease": "short-rib thoracic dysplasia 14 with polydactyly (Disease Ontology:DOID:0110096); Joubert syndrome 23 (Disease Ontology:DOID:0110992)", "pathway": " (mmu:76967)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21750036;21750661;25251415;25605945;26386247;31219806;34428180;35820727;37925530", "class_list": "", "function": "Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that talpid3-/- mouse embryos lack primary cilia and, like talpid(3) chicken embryos, have face and neural tube defects but also defects in left/right asymmetry., [RefSeq, PubMed]; Required for ciliogenesis and sonic hedgehog/SHH signaling (PubMed:21750036). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (By similarity). Involved in regulation of cell intracellular organization (PubMed:26386247). Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (PubMed:25251415)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RWX3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0001917 photoreceptor inner segment;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9PV87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G5E8Z2-1", "uniprot_id": "TAF4B_MOUSE", "mass": 89528.0, "length": 850, "protein_name": "Transcription initiation factor TFIID subunit 4B", "gene_name": "Taf4b", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 4B isoform 1", "refseq_ac": "NP_001093919", "gene_names_uniprotkb": "Taf4b; Taf2c2; Tafii105", "gene_names_refseq": "105kDa; 2610524B04Rik; 4932409F03Rik; TAFII-105; TAFII105; Taf2c2; Taf4b", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 4B; TAF(II)105; TAFII-105; TAFII105; Transcription initiation factor TFIID 105 kDa subunit", "protein_names_refseq": "TAF(II)105; TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105 kDa; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD; transcription initiation factor TFIID 105 kDa subunit; transcription initiation factor TFIID subunit 4B isoform 1; transcription initiation factor TFIID subunit 4B", "tax_id": 10090, "disease": "spermatogenic failure 13 (Disease Ontology:DOID:0070182)", "pathway": " (mmu:72504); (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "11557891;11856754;12192054;15774719;21750661;29187734;31219806;31914128;34428180;35043944;36852467", "class_list": "", "function": "Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators asond repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis., [UniProtKB, PubMed, UniProtKB, PubMed]; Has a pro-survival role in B and T lymphocytes, where the native protein is expressed; important for T cell maturation and for production of certain antibody isotypes., [RefSeq, PubMed]; Role of TAF(II)105 in B lymphocytes, [RefSeq, PubMed]; TAF4b transcription networks regulating early oocyte differentiation., [RefSeq, PubMed]; Taf4b mRNA and protein expression is differentially regulated during embryonic germ cell development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:2000648 positive regulation of stem cell proliferation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "G5E8Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YUB6-2", "uniprot_id": "BTBD8_MOUSE", "mass": 190845.0, "length": 1751, "protein_name": "BTB/POZ domain-containing protein 8", "gene_name": "Btbd8", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 8 isoform 1", "refseq_ac": "NP_001365195", "gene_names_uniprotkb": "Btbd8; Gm16115; Kiaa1107", "gene_names_refseq": "A830010M20Rik; AI849226; Btbd8; EG627196; Gm16115; mKIAA1107", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 8; AP2-interacting clathrin-endocytosis protein; APache", "protein_names_refseq": "AP2-interacting clathrin-endocytosis protein; APache; BTB (POZ) domain containing 8; BTB/POZ domain-containing protein 8 isoform 1; BTB/POZ domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;29262337;38558797", "class_list": "", "function": "APache is a presynaptic AP2 interactor on clathrin-coated vesicles. APache silencing impairs clathrin-mediated endocytosis and synaptic function., [RefSeq, PubMed]; Btbd8 deficiency reduces susceptibility to colitis by enhancing intestinal barrier function and suppressing inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5RL96;E9PUC9;E9QLA8;Q3TPG8;Q80TK0;Q8BRQ7;Q8BRS6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030424 axon;GO:0030122 AP-2 adaptor complex", "go_biological_process": "GO:0016182 synaptic vesicle budding from endosome;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "D3YUB6-2", "record_type": "protein" }, { "uniprot_canonical_ac": "O35382-1", "uniprot_id": "EXOC4_MOUSE", "mass": 110545.0, "length": 975, "protein_name": "Exocyst complex component 4", "gene_name": "Exoc4", "organism": "Mouse", "refseq_name": "exocyst complex component 4 isoform 1", "refseq_ac": "NP_033174", "gene_names_uniprotkb": "Exoc4; Sec8l1; Sec8", "gene_names_refseq": "Exoc4; Sec8l1; Sec8", "protein_names_uniprotkb": "Exocyst complex component 4; Exocyst complex component Sec8", "protein_names_refseq": "SEC8-like 1; exocyst complex component 4 isoform 1; exocyst complex component Sec8", "tax_id": 10090, "disease": "", "pathway": " (mmu:20336); (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12738960;15878854;17296554;17827149;21183079;25428506;30084848;30779550;34203471;34428180;39627609;9441674", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB]; SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. Interactions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons., [RefSeq, PubMed]; The exocyst complex serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0032584 growth cone membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005813 centrosome", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:0051223 regulation of protein transport;GO:0006612 protein targeting to membrane;GO:0007268 chemical synaptic transmission;GO:0050850 positive regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O35382-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11590-1", "uniprot_id": "MUP4_MOUSE", "mass": 20542.0, "length": 178, "protein_name": "Major urinary protein 4", "gene_name": "Mup4", "organism": "Mouse", "refseq_name": "major urinary protein 4 precursor", "refseq_ac": "NP_032674", "gene_names_uniprotkb": "Mup4", "gene_names_refseq": "Mup-4; Mup1; Mup4", "protein_names_uniprotkb": "Major urinary protein 4; MUP 4", "protein_names_refseq": "MUP 4; major urinary protein 1; major urinary protein 4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17843)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12192080;20509168;31044023;3600652;3600653", "class_list": "", "function": "Binds pheromones, likely to displace pheromones complexed to urinary MUPs and transport them to the vomeronasal organ (VNO) where they associate with their neuronal receptor(s). MUP4 is highly specific for the male mouse pheromone 2-sec-butyl-4,5-dihydrothiazole (SBT)., [UniProtKB, PubMed, PubMed]; Data determine the X-ray crystal structure of major urinary protein-IV bound to three mouse pheromones: SBT, 2,5-dimethylpyrazine, and 2-heptanone, and report the structure of MUP-IV with 2-ethylhexanol bound in the cavity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NS59-1", "uniprot_id": "F135A_MOUSE", "mass": 166857.0, "length": 1506, "protein_name": "Protein FAM135A", "gene_name": "Fam135a", "organism": "Mouse", "refseq_name": "protein FAM135A isoform 3", "refseq_ac": "NP_080880", "gene_names_uniprotkb": "Fam135a", "gene_names_refseq": "4921533L14Rik; Fam135a", "protein_names_uniprotkb": "Protein FAM135A", "protein_names_refseq": "protein FAM135A isoform 3; protein FAM135A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68187); (R-MMU-9696273)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "21750661;22872234;30059200;31219806;32782141;32848054;34203471;34428180;36210013;36852467;40021952;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEW1;Q5XK31;Q8BXS8;Q8BZL9;Q8K2K2;Q9D2J6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6NS59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66X05-1", "uniprot_id": "NAL4F_MOUSE", "mass": 110368.0, "length": 959, "protein_name": "NACHT, LRR and PYD domains-containing protein 4F", "gene_name": "Nlrp4f", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nlrp4f; Nalp4f", "gene_names_refseq": "", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 4F; NALP-kappa", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:97895)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15317747;21750661;31575650", "class_list": "", "function": "Required for cytoplasmic lattice formation, thereby modulates the distribution of organelles during oocyte maturation and zygote development (PubMed:31575650). Required for preimplantation development in female fertility (PubMed:31575650). May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006954 inflammatory response;GO:0007015 actin filament organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q66X05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0E5-1", "uniprot_id": "EFC11_MOUSE", "mass": 18470.0, "length": 162, "protein_name": "EF-hand calcium-binding domain-containing protein 11", "gene_name": "Efcab11", "organism": "Mouse", "refseq_name": "EF-hand calcium-binding domain-containing protein 11 isoform 1", "refseq_ac": "NP_084448", "gene_names_uniprotkb": "Efcab11", "gene_names_refseq": "2610021K21Rik; 2610110A13Rik; Efcab11", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 11", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 11 isoform 1; EF-hand calcium-binding domain-containing protein 11; EF-hand domain-containing protein C14orf143 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78767)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D041", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D0E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DIA2-1", "uniprot_id": "EX3L4_MOUSE", "mass": 81035.0, "length": 721, "protein_name": "Exocyst complex component 3-like protein 4", "gene_name": "Exoc3l4", "organism": "Mouse", "refseq_name": "exocyst complex component 3-like protein 4", "refseq_ac": "NP_001276416", "gene_names_uniprotkb": "Exoc3l4", "gene_names_refseq": "1200009I06Rik; 1600013K19Rik; Exoc3l4", "protein_names_uniprotkb": "Exocyst complex component 3-like protein 4", "protein_names_refseq": "SEC6-like protein C14orf73 homolog; exocyst complex component 3-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:74190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UY5;Q9DAX8", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0000145 exocyst", "go_biological_process": "GO:0051601 exocyst localization;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DIA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NSV7-1", "uniprot_id": "F149B_MOUSE", "mass": 63213.0, "length": 578, "protein_name": "Primary cilium assembly protein FAM149B1", "gene_name": "Fam149b1; Fam149b", "organism": "Mouse", "refseq_name": "primary cilium assembly protein FAM149B1 isoform 1", "refseq_ac": "NP_001019683", "gene_names_uniprotkb": "Fam149b1; Fam149b; Fam149b; Kiaa0974", "gene_names_refseq": "Fam149b1; Fam149b; mKIAA0974", "protein_names_uniprotkb": "Primary cilium assembly protein FAM149B1", "protein_names_refseq": "primary cilium assembly protein FAM149B1 isoform 1; primary cilium assembly protein FAM149B1; protein FAM149B1", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777)", "pathway": " (mmu:105428)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30905400", "class_list": "", "function": "Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JLS8;Q6PES0;Q6ZQ13;Q8CCW6;Q8R3J2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NSV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TS68-1", "uniprot_id": "NSUN6_MOUSE", "mass": 52279.0, "length": 476, "protein_name": "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6", "gene_name": "Nsun6", "organism": "Mouse", "refseq_name": "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform a", "refseq_ac": "NP_001159413", "gene_names_uniprotkb": "Nsun6", "gene_names_refseq": "4933403D21Rik; 4933414E04Rik; NOPD1; Nsun6", "protein_names_uniprotkb": "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6; 2.1.1.-; NOL1/NOP2/Sun domain family member 6", "protein_names_refseq": "NOL1/NOP2/Sun domain family 6; putative methyltransferase NSUN6; tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform a; tRNA (cytosine(72)-C(5))-methyltransferase NSUN6", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autosomal recessive intellectual developmental disorder 82 (Disease Ontology:DOID:0060947)", "pathway": " (mmu:74455)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;33330931", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates., [UniProtKB, UniProtKB]; Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3C4;Q9D445", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding;GO:0003723 RNA binding;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0002946 tRNA C5-cytosine methylation;GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0001510 RNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TS68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D753-1", "uniprot_id": "EXOS8_MOUSE", "mass": 29949.0, "length": 276, "protein_name": "Exosome complex component RRP43", "gene_name": "Exosc8", "organism": "Mouse", "refseq_name": "exosome complex component RRP43 isoform 2", "refseq_ac": "NP_081424", "gene_names_uniprotkb": "Exosc8; Rrp43", "gene_names_refseq": "2310032N20Rik; CIP3; Exosc8; mKIAA4013", "protein_names_uniprotkb": "Exosome complex component RRP43; Exosome component 8; Ribosomal RNA-processing protein 43", "protein_names_refseq": "exosome complex component RRP43 isoform 2; exosome complex component RRP43; exosome complex exonuclease RRP43; ribosomal RNA-processing protein 43", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 1C (Disease Ontology:DOID:0112334)", "pathway": " (mmu:69639); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;31219806;34428180;36210013", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006396 RNA processing;GO:0016075 rRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66X03-1", "uniprot_id": "NLR9A_MOUSE", "mass": 109680.0, "length": 949, "protein_name": "NACHT, LRR and PYD domains-containing protein 9A", "gene_name": "Nlrp9a", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 9A isoform 1", "refseq_ac": "NP_001041684", "gene_names_uniprotkb": "Nlrp9a; Nalp9a", "gene_names_refseq": "D7Ertd565e; Nalp-theta; Nalp9a; Nlrp9a", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 9A; NALP-theta", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 9A isoform 1; NACHT, LRR and PYD domains-containing protein 9A", "tax_id": 10090, "disease": "", "pathway": " (mmu:233001)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15317747;21750661", "class_list": "", "function": "May be involved in inflammation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6UQE7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050727 regulation of inflammatory response;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66X03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58659-1", "uniprot_id": "EVA1C_MOUSE", "mass": 49287.0, "length": 440, "protein_name": "Protein eva-1 homolog C", "gene_name": "Eva1c", "organism": "Mouse", "refseq_name": "protein eva-1 homolog C isoform 1 precursor", "refseq_ac": "NP_001186139", "gene_names_uniprotkb": "Eva1c; 4931408A02Rik; Fam176c", "gene_names_refseq": "1700092M14Rik; 4931408A02Rik; Eva1c; Fam176c", "protein_names_uniprotkb": "Protein eva-1 homolog C; Protein FAM176C", "protein_names_refseq": "protein FAM176C; protein eva-1 homolog C isoform 1 precursor; protein eva-1 homolog C", "tax_id": 10090, "disease": "", "pathway": " (mmu:70967)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11707072;21750661;24040182;25122090", "class_list": "", "function": "Binds heparin., [UniProtKB, UniProtKB, UniProtKB]; We demonstrate that MADD-4 interacts with an EVA-1/UNC-40 co-receptor complex to attract cell extensions Publication Status: Online-Only, [RefSeq, PubMed]; We report that EVA1C is expressed by axons contributing to commissures, tracts and nerve pathways of the developing spinal cord and forebrain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2RSZ2;Q497W3;Q9D4L3", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P58659-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q711T7-1", "uniprot_id": "NADE_MOUSE", "mass": 81652.0, "length": 725, "protein_name": "Glutamine-dependent NAD(+) synthetase", "gene_name": "Nadsyn1", "organism": "Mouse", "refseq_name": "glutamine-dependent NAD(+) synthetase isoform 3", "refseq_ac": "NP_001295024", "gene_names_uniprotkb": "Nadsyn1", "gene_names_refseq": "9130012B15Rik; Nadsyn1", "protein_names_uniprotkb": "Glutamine-dependent NAD(+) synthetase; 6.3.5.1; NAD(+) synthase [glutamine-hydrolyzing]; NAD(+) synthetase; NH3-dependent NAD(+) synthetase-like protein", "protein_names_refseq": "NAD(+) synthase; NH3-dependent NAD(+) synthetase-like protein; glutamine-dependent NAD(+) synthetase isoform 3; glutamine-dependent NAD(+) synthetase", "tax_id": 10090, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:78914); (R-MMU-196807)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12547821;21750661;25428506;30084848;38357931", "class_list": "", "function": "A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q711P6;Q8CFY6;Q9D280", "ec_number_list": "6.3.5.1", "go_molecular_function": "GO:0008795 NAD+ synthase activity;GO:0005524 ATP binding;GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity;GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q711T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JX4-1", "uniprot_id": "EIF3M_MOUSE", "mass": 42517.0, "length": 374, "protein_name": "Eukaryotic translation initiation factor 3 subunit M", "gene_name": "Eif3m", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit M", "refseq_ac": "NP_663355", "gene_names_uniprotkb": "Eif3m; Pcid1", "gene_names_refseq": "Eif3m; Ga17; Pcid1; Tango7", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit M; PCI domain-containing protein 1; eIF3m", "protein_names_refseq": "PCI domain containing 1 (herpesvirus entry mediator); PCI domain-containing protein 1; dendritic cell protein GA17; eukaryotic translation initiation factor 3 subunit M", "tax_id": 10090, "disease": "", "pathway": " (mmu:98221); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "21750661;22872234;24003236;25428506;30084848;31219806;31599954;34428180;37507081", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP]; Not only is eIF3m an essential gene, but its expression level is also important for mouse embryonic development and the control of organ size., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI04;Q5EBI5", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006412 translation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99JX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFD5-1", "uniprot_id": "ERCC8_MOUSE", "mass": 43689.0, "length": 397, "protein_name": "DNA excision repair protein ERCC-8", "gene_name": "Ercc8", "organism": "Mouse", "refseq_name": "DNA excision repair protein ERCC-8 isoform 1", "refseq_ac": "NP_082318", "gene_names_uniprotkb": "Ercc8; Ckn1; Csa", "gene_names_refseq": "2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; Ckn1; Csa; Ercc8", "protein_names_uniprotkb": "DNA excision repair protein ERCC-8; Cockayne syndrome WD repeat protein CSA homolog", "protein_names_refseq": "Cockayne syndrome 1 homolog; DNA excision repair protein ERCC-8 isoform 1; DNA excision repair protein ERCC-8; cockayne syndrome WD repeat protein CSA homolog", "tax_id": 10090, "disease": "UV-sensitive syndrome (Disease Ontology:DOID:0060240); Cockayne syndrome A (Disease Ontology:DOID:0080907); Cockayne syndrome (Disease Ontology:DOID:2962)", "pathway": " (mmu:71991); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-8951664)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "12509261;15340056;21750661;25762674;34628368", "class_list": "", "function": "Difference in oxidative DNA damage sensitivity between CSA- and CSB-deficient cell lines and mice, [RefSeq, PubMed]; Neurovascular dysfunction and neuroinflammation in a Cockayne syndrome mouse model., [RefSeq, PubMed]; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes. Following recruitment to lesion-stalled RNA polymerase II (Pol II), the CSA complex mediates ubiquitination of Pol II subunit POLR2A/RPB1 at 'Lys-1268', a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. The CSA complex also promotes the ubiquitination and subsequent proteasomal degradation of ERCC6/CSB in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Also plays a role in DNA double-strand breaks (DSSBs) repair by non-homologous end joining (NHEJ)., [UniProtKB, UniProtKB]; This study demonistrated that Cockayne syndrome group A deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U066;Q8VDC4;Q9CWK7", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0043204 perikaryon;GO:0016363 nuclear matrix", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006979 response to oxidative stress;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010996 response to auditory stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CFD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU00-1", "uniprot_id": "NRF1_MOUSE", "mass": 53571.0, "length": 503, "protein_name": "Nuclear respiratory factor 1", "gene_name": "Nrf1", "organism": "Mouse", "refseq_name": "nuclear respiratory factor 1 isoform a", "refseq_ac": "NP_001157698", "gene_names_uniprotkb": "Nrf1", "gene_names_refseq": "D6Ertd415e; Nrf1", "protein_names_uniprotkb": "Nuclear respiratory factor 1; Alpha palindromic-binding protein; Alpha-pal; NRF-1", "protein_names_refseq": "NRF-1; alpha palindromic-binding protein; alpha-pal; nuclear respiratory factor 1 isoform a", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18181)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10656923;21750661;31219806;39125617;39325625;40128797", "class_list": "", "function": "Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation., [RefSeq, PubMed]; Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, against MASLD Progression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXE4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051602 response to electrical stimulus;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WU00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P6P7-1", "uniprot_id": "PARP6_MOUSE", "mass": 71176.0, "length": 630, "protein_name": "Protein mono-ADP-ribosyltransferase PARP6", "gene_name": "Parp6", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP6 isoform 1", "refseq_ac": "NP_001192168", "gene_names_uniprotkb": "Parp6", "gene_names_refseq": "1700119G14Rik; 2310028P13Rik; 3110038K10Rik; ARTD17; C030013N01Rik; PARP-6; Parp6", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP6; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; PARP-6; Poly [ADP-ribose] polymerase 6", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 17; poly [ADP-ribose] polymerase 6; protein mono-ADP-ribosyltransferase PARP6 isoform 1; protein mono-ADP-ribosyltransferase PARP6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67287)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26725726;34067418", "class_list": "", "function": "Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay. Publication Status: Online-Only, [RefSeq, PubMed]; Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PARP6 is a regulator of dendrite morphogenesis, supporting a role for mono-ADP-ribosylation in neurons during development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVW1", "ec_number_list": "2.4.2.-;2.4.2.30;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0050775 positive regulation of dendrite morphogenesis;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P6P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY45-1", "uniprot_id": "EFMT1_MOUSE", "mass": 24499.0, "length": 214, "protein_name": "EEF1A lysine methyltransferase 1", "gene_name": "Eef1akmt1", "organism": "Mouse", "refseq_name": "EEF1A lysine methyltransferase 1", "refseq_ac": "NP_080802", "gene_names_uniprotkb": "Eef1akmt1; EEF1AKMT1; N6AMT2; N6amt2", "gene_names_refseq": "2510005D08Rik; Ayu21-96; Eef1akmt1; Gt(pU21)96Imeg; GtAyu21-96; N6amt2", "protein_names_uniprotkb": "EEF1A lysine methyltransferase 1; 2.1.1.-; N(6)-adenine-specific DNA methyltransferase 2; Protein-lysine N-methyltransferase N6amt2", "protein_names_refseq": "EEF1A lysine methyltransferase 1; Gt(Ayu21)96Imeg; N-6 adenine-specific DNA methyltransferase 2 (putative); eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1; n(6)-adenine-specific DNA methyltransferase 2; protein-lysine N-methyltransferase N6amt2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68043); (R-MMU-8876725)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQR0", "ec_number_list": "2.1.1.-;2.1.1.359;3.6.5.-;2.1.1.372", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008168 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0018022 peptidyl-lysine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CY45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWQ0-1", "uniprot_id": "DPH5_MOUSE", "mass": 31218.0, "length": 281, "protein_name": "Diphthine methyl ester synthase", "gene_name": "Dph5", "organism": "Mouse", "refseq_name": "diphthine methyl ester synthase", "refseq_ac": "NP_081469", "gene_names_uniprotkb": "Dph5", "gene_names_refseq": "2410012M04Rik; Dph5", "protein_names_uniprotkb": "Diphthine methyl ester synthase; 2.1.1.314; Diphthamide biosynthesis methyltransferase", "protein_names_refseq": "DPH5 homolog; diphthamide biosynthesis methyltransferase; diphthine methyl ester synthase; diphthine synthase", "tax_id": 10090, "disease": "neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties (Disease Ontology:DOID:0070479)", "pathway": " (mmu:69740); (R-MMU-5358493)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15485916;19228953;21750661;34428180;35482014", "class_list": "", "function": "A novel DPH5-related diphthamide-deficiency syndrome causing embryonic lethality or profound neurodevelopmental disorder. Erratum:[Genet Med. 2022 Oct;24(10):2207. doi: 10.1016/j.gim.2022.07.021. PMID: 36205747], [RefSeq, PubMed]; Misfolded AR protein in the cytosol thus initiates a cascade of events beginning with JNK and culminating in Bax-dependent, intrinsic pathway activation, mediated in part by DP5/Hrk., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAC5", "ec_number_list": "3.6.5.-;2.1.1.314", "go_molecular_function": "GO:0004164 diphthine synthase activity;GO:0141133 diphthine methyl ester synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0001701 in utero embryonic development;GO:0007399 nervous system development;GO:0032259 methylation;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZQ9-1", "uniprot_id": "EIF3B_MOUSE", "mass": 91370.0, "length": 803, "protein_name": "Eukaryotic translation initiation factor 3 subunit B", "gene_name": "Eif3b", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit B", "refseq_ac": "NP_598677", "gene_names_uniprotkb": "Eif3b; Eif3s9", "gene_names_refseq": "D5Wsu45e; EIF3-ETA; EIF3-P110; EIF3-P116; Eif3b; Eif3s9; PRT1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit B; Eukaryotic translation initiation factor 3 subunit 9; eIF-3-eta; eIF3 p116; eIF3b", "protein_names_refseq": "eIF-3-eta; eIF3 p116; eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3, subunit 9 (eta)", "tax_id": 10090, "disease": "", "pathway": " (mmu:27979); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 27, "publication_id_list": "12038979;15345747;16452087;16541103;17242355;17581632;17622165;18630941;19131326;19144319;20485683;21183079;21540332;21750661;25428506;25605945;26495903;30084848;30556540;31219806;33725478;34428180;34887587;36288343;37453647;37507081;39627609", "class_list": "", "function": "Data illustrate a novel mechanism of piR-823 in HSC activities. The combination of piR-823 and EIF3B increased TGF-beta1 expression, which activates HSCs in liver fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, PubMed, HAMAP, PubMed]; Results indicate that p116 plays an essential role in the early stages of mouse development[eIF3 p116], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q922K2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8JZQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4V0-1", "uniprot_id": "EKI1_MOUSE", "mass": 41984.0, "length": 363, "protein_name": "Ethanolamine kinase 1", "gene_name": "Etnk1", "organism": "Mouse", "refseq_name": "ethanolamine kinase 1", "refseq_ac": "NP_083526", "gene_names_uniprotkb": "Etnk1; Eki1", "gene_names_refseq": "1110061E11Rik; 4930555L11Rik; D6Ertd3e; EKI1; Etnk1", "protein_names_uniprotkb": "Ethanolamine kinase 1; 2.7.1.82; EKI 1", "protein_names_refseq": "EKI 1; ethanolamine kinase 1", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:75320); (R-MMU-1483213)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;30084848;31219806;34428180", "class_list": "", "function": "Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6Y9V2;Q8BXQ0", "ec_number_list": "2.7.1.82;2.7.1.32", "go_molecular_function": "GO:0005524 ATP binding;GO:0004305 ethanolamine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0046474 glycerophospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D4V0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKP7-1", "uniprot_id": "DPOE3_MOUSE", "mass": 16629.0, "length": 145, "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "Pole3", "organism": "Mouse", "refseq_name": "DNA polymerase epsilon subunit 3", "refseq_ac": "NP_067473", "gene_names_uniprotkb": "Pole3", "gene_names_refseq": "1810034K18Rik; Pole3; YBL1", "protein_names_uniprotkb": "DNA polymerase epsilon subunit 3; DNA polymerase II subunit 3; DNA polymerase epsilon subunit p17; NF-YB-like protein; YB-like protein 1; YBL1", "protein_names_refseq": "DNA polymerase II subunit 3; DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; NF-YB-like protein; YB-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:59001); (R-MMU-110314); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-68952); (R-MMU-68962)", "pathway_count": 12, "publication_count": 4, "publication_id_list": "11000277;21750661;34428180;37828378", "class_list": "", "function": "Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R198", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031490 chromatin DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005721 pericentric heterochromatin;GO:0008623 CHRAC;GO:0140672 ATAC complex;GO:0005634 nucleus", "go_biological_process": "GO:0006272 leading strand elongation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006974 DNA damage response;GO:0006275 regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JKP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLJ4-1", "uniprot_id": "ELOV2_MOUSE", "mass": 34207.0, "length": 292, "protein_name": "Very long chain fatty acid elongase 2", "gene_name": "Elovl2", "organism": "Mouse", "refseq_name": "very long chain fatty acid elongase 2 isoform 2", "refseq_ac": "NP_001298050", "gene_names_uniprotkb": "Elovl2; ELOVL2; Ssc2", "gene_names_refseq": "Elovl2; Ssc2", "protein_names_uniprotkb": "Very long chain fatty acid elongase 2; 2.3.1.199; 3-keto acyl-CoA synthase Elovl2; ELOVL FA elongase 2; ELOVL fatty acid elongase 2; Elongation of very long chain fatty acids protein 2; Very long chain 3-ketoacyl-CoA synthase 2; Very long chain 3-oxoacyl-CoA synthase 2", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl2; ELOVL FA elongase 2; ELOVL family member 2; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2; elongation of very long chain fatty acids protein 2; sequence similarity to Cig30 2; very long chain 3-ketoacyl-CoA synthase 2; very long chain 3-oxoacyl-CoA synthase 2; very long chain fatty acid elongase 2 isoform 2; very long chain fatty acid elongase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:54326); (R-MMU-2046105); (R-MMU-2046106); (R-MMU-75876)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10791983;12371743;21106902;21750661;33963174;34428180;38485951;38763083", "class_list": "glycogene", "function": "ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Essential for the formation of C24:5(n-6) up to C30:5(n-6) PUFAs in testis, these fatty acids being indispensable for normal spermatogenesis and fertility., [UniProtKB, PubMed, HAMAP, PubMed, UniProtKB]; Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Publication Status: Online-Only, [RefSeq, PubMed]; Sex-dependent differences in tissue and blood n-3 PUFA levels following ALA or ALA + DHA feeding of liver-specific Elovl2-KO and control mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5Z2", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JLJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0G5-1", "uniprot_id": "EIPR1_MOUSE", "mass": 43127.0, "length": 386, "protein_name": "EARP and GARP complex-interacting protein 1", "gene_name": "Eipr1", "organism": "Mouse", "refseq_name": "EARP and GARP complex-interacting protein 1 isoform a", "refseq_ac": "NP_958745", "gene_names_uniprotkb": "Eipr1; Tssc1", "gene_names_refseq": "D12Ertd604e; Eipr1; Tssc1", "protein_names_uniprotkb": "EARP and GARP complex-interacting protein 1; Endosome-associated recycling protein-interacting protein; Golgi-associated retrograde protein-interacting protein; Tumor-suppressing STF cDNA 1 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein", "protein_names_refseq": "EARP and GARP complex-interacting protein 1 isoform a; EARP and GARP complex-interacting protein 1; EARP-interacting protein; Golgi-associated retrograde protein-interacting protein; endosome-associated recycling protein-interacting protein; protein TSSC1; tumor suppressing subtransferable candidate 1; tumor-suppressing STF cDNA 1 protein; tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:380752)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23933319;31219806;34428180", "class_list": "", "function": "Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (By similarity). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (By similarity). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (By similarity). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of Runx2 induces bone osteolysis in a TSSC1-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QN80", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005802 trans-Golgi network", "go_biological_process": "GO:1904811 positive regulation of dense core granule transport;GO:0050796 regulation of insulin secretion;GO:0016567 protein ubiquitination;GO:2001137 positive regulation of endocytic recycling;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K0G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D903-1", "uniprot_id": "EBP2_MOUSE", "mass": 34703.0, "length": 306, "protein_name": "Probable rRNA-processing protein EBP2", "gene_name": "Ebna1bp2", "organism": "Mouse", "refseq_name": "probable rRNA-processing protein EBP2", "refseq_ac": "NP_081208", "gene_names_uniprotkb": "Ebna1bp2; Ebp2", "gene_names_refseq": "1810014B19Rik; B830003A16Rik; Ebna1bp2; Ebp2; Nobp; p40", "protein_names_uniprotkb": "Probable rRNA-processing protein EBP2", "protein_names_refseq": "probable rRNA-processing protein EBP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69072); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25428506;32782141", "class_list": "", "function": "Required for the processing of the 27S pre-rRNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ACZ0;Q3TKB5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome;GO:0034399 nuclear periphery", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D903-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LC8-1", "uniprot_id": "EI2BA_MOUSE", "mass": 33816.0, "length": 305, "protein_name": "Translation initiation factor eIF2B subunit alpha", "gene_name": "Eif2b1", "organism": "Mouse", "refseq_name": "translation initiation factor eIF2B subunit alpha", "refseq_ac": "NP_663346", "gene_names_uniprotkb": "Eif2b1", "gene_names_refseq": "D5Ertd406e; EIF2BA; Eif2b1", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit alpha; eIF2B GDP-GTP exchange factor subunit alpha", "protein_names_refseq": "eIF-2B GDP-GTP exchange factor subunit alpha; eIF2B GDP-GTP exchange factor subunit alpha; eukaryotic translation initiation factor 2B, subunit 1 (alpha); eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa); translation initiation factor eIF-2B subunit alpha; translation initiation factor eIF2B subunit alpha", "tax_id": 10090, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 1 (Disease Ontology:DOID:0070374)", "pathway": " (mmu:209354); (R-MMU-72731)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12773302;21750661;25428506;34428180;36210013", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha phosphorylation, reduction of eIF2B activity, and inhibition of eIF4F complex formation., [RefSeq, PubMed]; This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits. The eIF2B complex is a critical regulator of protein synthesis acting as the guanine nucleotide exchange factor for eIF2 to enable the formation of ternary complex that is required for the initiation of mRNA translation. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0050852 T cell receptor signaling pathway;GO:0006413 translational initiation;GO:0006412 translation;GO:1990928 response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99LC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMC3-1", "uniprot_id": "DNJA4_MOUSE", "mass": 44902.0, "length": 397, "protein_name": "DnaJ homolog subfamily A member 4", "gene_name": "Dnaja4", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily A member 4 isoform 2", "refseq_ac": "NP_067397", "gene_names_uniprotkb": "Dnaja4", "gene_names_refseq": "1110021L12Rik; Dj4; Dnaja4; Hsj4; mmDjA4", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 4; MmDjA4", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily A, member 4; dnaJ homolog subfamily A member 4 isoform 2; dnaJ homolog subfamily A member 4; heat shock protein, DNAJ-like 4", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:58233); (R-MMU-3371497)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10978524;12380683;16950652;21750661;34428180", "class_list": "", "function": "Hsc70/hsp70-dj4 chaperone pair protects the heart muscle cells from various stresses, [RefSeq, PubMed]; The DnaJA4 chaperone can be viewed as a new player in cholesterol synthesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RW09;Q543S9;Q9CTD6;Q9CUD4", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0010628 positive regulation of gene expression;GO:0034605 cellular response to heat;GO:0010596 negative regulation of endothelial cell migration;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JMC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB10-1", "uniprot_id": "EMRE_MOUSE", "mass": 11542.0, "length": 107, "protein_name": "Essential MCU regulator, mitochondrial", "gene_name": "Smdt1", "organism": "Mouse", "refseq_name": "essential MCU regulator, mitochondrial precursor", "refseq_ac": "NP_081190", "gene_names_uniprotkb": "Smdt1; 1500032L24Rik; Emre", "gene_names_refseq": "1500032L24Rik; Emre; Smdt1", "protein_names_uniprotkb": "Essential MCU regulator, mitochondrial; Single-pass membrane protein with aspartate-rich tail 1, mitochondrial", "protein_names_refseq": "UPF0466 protein C22orf32 homolog, mitochondrial; essential MCU regulator, mitochondrial precursor; essential MCU regulator, mitochondrial; single-pass membrane protein with aspartate-rich tail 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:69029); (R-MMU-8949215); (R-MMU-8949664); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "21750661;24231807;27001609;27637331;34428180;37230379", "class_list": "", "function": "Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term., [RefSeq, PubMed]; Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58EA5", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0099103 channel activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990246 uniplex complex", "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0072732 cellular response to calcium ion starvation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DB10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z218-1", "uniprot_id": "DPP6_MOUSE", "mass": 91260.0, "length": 804, "protein_name": "A-type potassium channel modulatory protein DPP6", "gene_name": "Dpp6", "organism": "Mouse", "refseq_name": "A-type potassium channel modulatory protein DPP6 isoform 2", "refseq_ac": "NP_034205", "gene_names_uniprotkb": "Dpp6; Dpp-6", "gene_names_refseq": "B930011P16Rik; D5Buc3; D5Buc4; D5Buc5; DPP VI; Dpp-6; Dpp6; Gm1377; In(5)6H-p; Peplb; Rw", "protein_names_uniprotkb": "A-type potassium channel modulatory protein DPP6; DPP VI; DPPX; Dipeptidyl aminopeptidase-like protein 6; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI", "protein_names_refseq": "A-type potassium channel modulatory protein DPP6 isoform 2; A-type potassium channel modulatory protein DPP6; DPPX; dipeptidyl aminopeptidase-like protein 6; dipeptidyl aminopeptidase-related protein; dipeptidyl peptidase IV-like protein; dipeptidyl peptidase VI; dipeptidylpeptidase VI; inversion, Chr 5, Harwell 6, proximal", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); spinal muscular atrophy (Disease Ontology:DOID:12377); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:13483)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22311982;23832105;30899004;33300544;34997220;36209950;40885482;9811881", "class_list": "", "function": "Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:34997220). Modulates the activity and gating characteristics of the potassium channel KCND2 amd KCND3 (PubMed:22311982, PubMed:34997220). Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982). Has no dipeptidyl aminopeptidase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 44, "disease_count": 3, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWW2;Q9Z219", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis;GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "Q9Z218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1N5-1", "uniprot_id": "DX39B_MOUSE", "mass": 49035.0, "length": 428, "protein_name": "Spliceosome RNA helicase Ddx39b", "gene_name": "Ddx39b", "organism": "Mouse", "refseq_name": "spliceosome RNA helicase Ddx39b", "refseq_ac": "NP_001239386", "gene_names_uniprotkb": "Ddx39b; Bat1a; Bat1; Uap56", "gene_names_refseq": "0610030D10Rik; Bat-1; Bat1a; Bat1; D17H6S81E-1; D17H6S81E; D6S81Eh; Ddx39b", "protein_names_uniprotkb": "Spliceosome RNA helicase Ddx39b; 3.6.4.13; 56 kDa U2AF65-associated protein; DEAD box protein UAP56; HLA-B-associated transcript 1 protein", "protein_names_refseq": "56 kDa U2AF65-associated protein; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; HLA-B-associated transcript 1A; nuclear RNA helicase Bat1; spliceosome RNA helicase Bat1; spliceosome RNA helicase Ddx39b", "tax_id": 10090, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:53817); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-9013418)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "14656967;21750661;29164525;32209106;34428180;37453647;37507081;39627609", "class_list": "", "function": "DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-kappaB and sensitize to alkylating chemotherapy. Publication Status: Online-Only, [RefSeq, PubMed]; Ectopic UAP56 upregulated HSF4-controlled HSP25 and alpha B-crystallin proteins expression, while knocking down UAP56 by shRNA reversed it., [RefSeq, PubMed]; Involved in nuclear export of spliced and unspliced mRNA. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B. Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability., [UniProtKB, UniProtKB]; Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8HW97", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.2.1.8;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;3.4.19.12;7.2.2.-;7.6.2.16;2.7.11.1;2.7.7.19;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.6.5.2;2.7.1.78;3.1.27.-", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation;GO:0045727 positive regulation of translation;GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z1N5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C9A2-3", "uniprot_id": "ENDOV_MOUSE", "mass": 37174.0, "length": 338, "protein_name": "Endonuclease V", "gene_name": "Endov", "organism": "Mouse", "refseq_name": "endonuclease V isoform 1", "refseq_ac": "NP_001158108", "gene_names_uniprotkb": "Endov", "gene_names_refseq": "A730011L01Rik; Endov", "protein_names_uniprotkb": "Endonuclease V; 3.1.26.-", "protein_names_refseq": "endonuclease V isoform 1; novel endonuclease V protein; putative endonuclease FLJ39025 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:338371)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12853604;27108838;32083667", "class_list": "", "function": "Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures., [UniProtKB, UniProtKB]; Mouse Endonuclease V shares substrate preferences with human EndoV by catalyzing cleavage at inosines in RNA and being inert towards inosines in DNA. Publication Status: Online-Only, [RefSeq, PubMed]; The data suggest that EndoV is involved in the development of hepatocellular carcinoma in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATE4;Q3TCQ4;Q8C3Y1", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0003727 single-stranded RNA binding;GO:0016888 DNA endonuclease activity, producing 5'-phosphomonoesters;GO:0016891 RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C9A2-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZR4-1", "uniprot_id": "EAA5_MOUSE", "mass": 60106.0, "length": 559, "protein_name": "Excitatory amino acid transporter 5", "gene_name": "Slc1a7", "organism": "Mouse", "refseq_name": "excitatory amino acid transporter 5", "refseq_ac": "NP_666367", "gene_names_uniprotkb": "Slc1a7", "gene_names_refseq": "A930031E15Rik; Eaat5; Slc1a7", "protein_names_uniprotkb": "Excitatory amino acid transporter 5; Solute carrier family 1 member 7", "protein_names_refseq": "excitatory amino acid transporter 5; solute carrier family 1 member 7", "tax_id": 10090, "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:242607); (R-MMU-210500); (R-MMU-9958863)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16973698;21750661;32233906;34772693;35523583", "class_list": "", "function": "Excitatory Amino Acid Transporter EAAT5 Improves Temporal Resolution in the Retina. Publication Status: Online-Only, [RefSeq, PubMed]; Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina (PubMed:16973698, PubMed:32233906)., [UniProtKB, PubMed, UniProtKB, PubMed]; These results indicate that EAAT5 acts as a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A8F0", "ec_number_list": "", "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity;GO:0008068 extracellularly glutamate-gated chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0043679 axon terminus;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:1902476 chloride transmembrane transport;GO:0001504 neurotransmitter uptake;GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8JZR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K482-1", "uniprot_id": "EMIL2_MOUSE", "mass": 117310.0, "length": 1074, "protein_name": "EMILIN-2", "gene_name": "Emilin2", "organism": "Mouse", "refseq_name": "EMILIN-2 isoform 1 precursor", "refseq_ac": "NP_660140", "gene_names_uniprotkb": "Emilin2", "gene_names_refseq": "Emilin2; FOAP-10", "protein_names_uniprotkb": "EMILIN-2; Basilin; Elastin microfibril interface-located protein 2; Elastin microfibril interfacer 2", "protein_names_refseq": "EMILIN-2 isoform 1 precursor; EMILIN-2; basilin; elastin microfibril interface located protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:246707); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12221002;12837629;19144319;21183079;21750661;37579864", "class_list": "", "function": "Cochlear emilin-2 mRNA is expressed in the tympanic border cells and an antibody detected protein in the extracellular matrix surrounding the collagenous fibers in the cochlear basilar membrane, [RefSeq, PubMed]; Emilin2 fosters vascular stability by promoting pericyte recruitment., [RefSeq, PubMed]; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Major component of the cochlear basilar membrane (BM) which may contribute to the developmental assembly or function of the BM., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber", "go_biological_process": "GO:0007155 cell adhesion;GO:0043065 positive regulation of apoptotic process;GO:0030336 negative regulation of cell migration;GO:0045766 positive regulation of angiogenesis;GO:0030194 positive regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K482-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0Z2-1", "uniprot_id": "ENOX2_MOUSE", "mass": 68285.0, "length": 598, "protein_name": "Ecto-NOX disulfide-thiol exchanger 2", "gene_name": "Enox2", "organism": "Mouse", "refseq_name": "ecto-NOX disulfide-thiol exchanger 2 isoform a", "refseq_ac": "NP_001258376", "gene_names_uniprotkb": "Enox2; Cova1", "gene_names_refseq": "APK1; Cova1; Enox2; tNOX", "protein_names_uniprotkb": "Ecto-NOX disulfide-thiol exchanger 2; APK1 antigen; Cytosolic ovarian carcinoma antigen 1; Tumor-associated hydroquinone oxidase; tNOX", "protein_names_refseq": "APK1 antigen; cytosolic ovarian carcinoma antigen 1; ecto-NOX disulfide-thiol exchanger 2 isoform a; tumor-associated hydroquinone oxidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:209224)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17115410;18980249;21625959;21750661;25428506;31219806;37061217", "class_list": "", "function": "Data show that growth of transgenic mouse embryonic fibroblasts overexpressing tNOX is inhibited by low concentrations of the anticarcinogenic tNOX inhibitors epigallocatechin-3-gallate and phenoxodiol., [RefSeq, PubMed]; ENOX2 inhibition enhances infiltration of effector memory T-cell and mediates response to chemotherapy in immune-quiescent nasopharyngeal carcinoma., [RefSeq, PubMed]; May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock (By similarity)., [UniProtKB, UniProtKB]; The tissue expression of tNOX mRNA was greatest in heart, lung and liver. When these tissues were analyzed for cell size., [RefSeq, PubMed]; This result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1B073;Q8BY59;Q8R372", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0016491 oxidoreductase activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0022900 electron transport chain;GO:0007624 ultradian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R0Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VF5-1", "uniprot_id": "EMID1_MOUSE", "mass": 45634.0, "length": 444, "protein_name": "EMI domain-containing protein 1", "gene_name": "Emid1", "organism": "Mouse", "refseq_name": "EMI domain-containing protein 1 isoform 1 precursor", "refseq_ac": "NP_542162", "gene_names_uniprotkb": "Emid1; Emu1", "gene_names_refseq": "CO-5; Emid1; Emu1", "protein_names_uniprotkb": "EMI domain-containing protein 1; Emilin and multimerin domain-containing protein 1; Emu1", "protein_names_refseq": "EMI domain-containing protein 1 isoform 1 precursor; EMI domain-containing protein 1; emilin and multimerin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:140703); (R-MMU-5173105)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12221002;21750661;30899004", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91VF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WG4-1", "uniprot_id": "ELP2_MOUSE", "mass": 93093.0, "length": 831, "protein_name": "Elongator complex protein 2", "gene_name": "Elp2", "organism": "Mouse", "refseq_name": "elongator complex protein 2 isoform 1", "refseq_ac": "NP_067423", "gene_names_uniprotkb": "Elp2; Statip1", "gene_names_refseq": "Elp2; Epl2; StIP1; Statip1", "protein_names_uniprotkb": "Elongator complex protein 2; ELP2; STAT3-interacting protein 1; StIP1", "protein_names_refseq": "STAT3-interacting protein 1; elongation protein 2 homolog; elongator complex protein 2 isoform 1; elongator complex protein 2; signal transducer and activator of transcription 3 interacting protein 1; signal transducer and activator of transcription interacting protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 58 (Disease Ontology:DOID:0081220); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:58523)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10954736;15223310;18299400;19224205;20173027;20484733;20485683;21952136;22872234;25428506;25428507;25605945;30084848;30779550;31219806;32152506;33649389;33976153;34203471;34428180;35820727;36210013;37828378;38159063", "class_list": "", "function": "CircELP2 reverse-splicing biogenesis and function as a pro-fibrogenic factor by targeting mitochondrial quality control pathway., [RefSeq, PubMed]; Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator comple catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB]; Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; STAT3 interacts with STRA13 and modulates transcription of STAT3-dependent targets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIH5;Q3TIT0;Q8CBW6;Q9ESY7", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0000993 RNA polymerase II complex binding;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008023 transcription elongation factor complex;GO:0000502 proteasome complex;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0006368 transcription elongation by RNA polymerase II;GO:0002098 tRNA wobble uridine modification;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q91WG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WK2-1", "uniprot_id": "EIF3H_MOUSE", "mass": 39832.0, "length": 352, "protein_name": "Eukaryotic translation initiation factor 3 subunit H", "gene_name": "Eif3h", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit H isoform 1", "refseq_ac": "NP_542366", "gene_names_uniprotkb": "Eif3h; Eif3s3", "gene_names_refseq": "1110008A16Rik; 40kD; 9430017H16Rik; EIF3-P40; EIF3-gamma; Eif3h; Eif3s3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit H; Eukaryotic translation initiation factor 3 subunit 3; eIF-3-gamma; eIF3 p40 subunit; eIF3h", "protein_names_refseq": "eIF3 p40 subunit; eukaryotic translation initiation factor 3 subunit 3; eukaryotic translation initiation factor 3 subunit H isoform 1; eukaryotic translation initiation factor 3, subunit 3 (gamma); eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:68135); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "17581632;18250455;21183079;25428506;25605945;26100019;27802388;30084848;34428180;35820727;36288343;37453647;37507081", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0003743 translation initiation factor activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91WK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YP6-1", "uniprot_id": "ELMD3_MOUSE", "mass": 42659.0, "length": 381, "protein_name": "ELMO domain-containing protein 3", "gene_name": "Elmod3", "organism": "Mouse", "refseq_name": "ELMO domain-containing protein 3", "refseq_ac": "NP_001240621", "gene_names_uniprotkb": "Elmod3; Rbed1", "gene_names_refseq": "C330008I15Rik; Elmod3; RBM29; Rbed1", "protein_names_uniprotkb": "ELMO domain-containing protein 3; RNA-binding motif and ELMO domain-containing protein 1", "protein_names_refseq": "ELMO domain-containing protein 3; RNA binding motif and ELMO domain 1; RNA-binding motif and ELMO domain-containing protein 1", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 81 (Disease Ontology:DOID:0070608); autosomal recessive nonsyndromic deafness 88 (Disease Ontology:DOID:0110533)", "pathway": " (mmu:232089)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22177965;24039609;31628468;34428180;34818063", "class_list": "", "function": "Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity., [UniProtKB]; Finding associates Elmod3 deficiencies with stereocilia dysmorphologies and reveals that they might play roles in the actin cytoskeleton dynamics in cochlear hair cells, and thus relate to hearing impairment., [RefSeq, PubMed]; The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic. Erratum:[Mol Biol Cell. 2022 Jun 1;33(7):cor1. doi: 10.1091/mbc.E21-09-0443_corr. PMID: 35612986], [RefSeq, PubMed]; The data demonstrate the ability of the SH3 domain of DOCK180 to interact with ELMO1, regardless of the presence of the polyproline-containing C-terminal end., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNV2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005929 cilium;GO:0060091 kinocilium;GO:0032420 stereocilium", "go_biological_process": "GO:0015031 protein transport;GO:0007010 cytoskeleton organization;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91YP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JW5-1", "uniprot_id": "EPCAM_MOUSE", "mass": 35019.0, "length": 315, "protein_name": "Epithelial cell adhesion molecule", "gene_name": "Epcam", "organism": "Mouse", "refseq_name": "epithelial cell adhesion molecule precursor", "refseq_ac": "NP_032558", "gene_names_uniprotkb": "Epcam; Tacstd1", "gene_names_refseq": "CD326; EGP-2; EGP; Egp314; Ep-CAM; EpCAM1; Epcam; GA733-2; Ly74; TROP1; Tacsd1; Tacstd1; gp40", "protein_names_uniprotkb": "Epithelial cell adhesion molecule; EGP314; Ep-CAM; Epithelial glycoprotein 314; Protein 289A; Tumor-associated calcium signal transducer 1; mEGP314", "protein_names_refseq": "Trop-1 protein; epithelial cell adhesion molecule precursor; epithelial glycoprotein 314; lymphocyte antigen 74; mEGP314; panepithelial glycoprotein 314; protein 289A; tumor-associated calcium signal transducer 1", "tax_id": 10090, "disease": "congenital diarrhea 5 with tufting enteropathy (Disease Ontology:DOID:0060776); hereditary nonpolyposis colorectal cancer type 8 (Disease Ontology:DOID:0070270); middle cerebral artery infarction (Disease Ontology:DOID:3525); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:17075); (R-MMU-202733)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;1729376;21750661", "class_list": "", "function": "May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61512", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0098641 cadherin binding involved in cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99JW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99K41-1", "uniprot_id": "EMIL1_MOUSE", "mass": 107585.0, "length": 1017, "protein_name": "EMILIN-1", "gene_name": "Emilin1", "organism": "Mouse", "refseq_name": "EMILIN-1 precursor", "refseq_ac": "NP_598679", "gene_names_uniprotkb": "Emilin1", "gene_names_refseq": "5830419M17Rik; EMILIN-1; Emilin1; gp115", "protein_names_uniprotkb": "EMILIN-1; Elastin microfibril interface-located protein 1; Elastin microfibril interfacer 1", "protein_names_refseq": "EMILIN-1 precursor; elastin microfibril interface located protein 1", "tax_id": 10090, "disease": "autosomal dominant distal hereditary motor neuronopathy 10 (Disease Ontology:DOID:0081399)", "pathway": " (mmu:100952); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12475644;14701737;15705587;28717224;30779550;31219806;36351433;38941035;39627609", "class_list": "", "function": "Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6-oxidase/LOX activity (PubMed:36351433). May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved the processes that regulate vessel assembly. Has cell adhesive capacity (By similarity). May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue., [UniProtKB, PubMed]; May regulate elastogenesis and vascular cell maintenance by stabilizing molecular interactions between elastic fiber components and by endowing elastic fibers with specific cell adhesion properties, [RefSeq, PubMed]; The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression., [RefSeq, PubMed]; Transcription in different tissues is achieved through combinatorial cooperation between various regions, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0098640 integrin binding involved in cell-matrix adhesion;GO:0030023 extracellular matrix constituent conferring elasticity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber", "go_biological_process": "GO:0050866 negative regulation of cell activation;GO:1905522 negative regulation of macrophage migration;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q99K41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ94-1", "uniprot_id": "DNJ5B_MOUSE", "mass": 22662.0, "length": 199, "protein_name": "DnaJ homolog subfamily C member 5B", "gene_name": "Dnajc5b", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 5B", "refseq_ac": "NP_001157008", "gene_names_uniprotkb": "Dnajc5b; Cspbeta", "gene_names_refseq": "1700008A05Rik; Dnajc5b", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 5B; CSP-beta; Cysteine-string protein isoform beta", "protein_names_refseq": "CSP-beta; DnaJ (Hsp40) homolog, subfamily C, member 5 beta; beta cysteine string protein; beta-CSP; cysteine string protein beta; dnaJ homolog subfamily C member 5B", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 4 (Disease Ontology:DOID:0110720); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (mmu:66326)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17034881;20338151;34428180", "class_list": "", "function": "The enrichment of CSP-beta in synaptosomes and the association of CSP-beta with synaptic vesicles suggest that CSP-beta, like CSP-alpha, may be an important component of the regulated secretory machinery in mouse brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810R9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030658 transport vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQ94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQW0-1", "uniprot_id": "EMC6_MOUSE", "mass": 12017.0, "length": 110, "protein_name": "ER membrane protein complex subunit 6", "gene_name": "Emc6", "organism": "Mouse", "refseq_name": "ER membrane protein complex subunit 6", "refseq_ac": "NP_001161942", "gene_names_uniprotkb": "Emc6; Tmem93", "gene_names_refseq": "0610009E20Rik; 0610025L18Rik; Emc6; Tmem93", "protein_names_uniprotkb": "ER membrane protein complex subunit 6; Transmembrane protein 93", "protein_names_refseq": "ER membrane protein complex subunit 6; transmembrane protein 93", "tax_id": 10090, "disease": "", "pathway": " (mmu:66048)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30982575", "class_list": "", "function": "Adenovirus-mediated ectopic overexpression of EMC6 (Ad5-EMC6) decreases the activity of ERK1/2, down-regulates the levels of BCL-2 and increases the ratio of BAX/BCL-2. Ad5-EMC6 mediates anti-tumor activity through the mitochondrial apoptosis pathway. Ad5-EMC6 enhances the sensitivity of gastric cancer cells to the etoposide., [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ41", "ec_number_list": "", "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:1903349 omegasome membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0U1-1", "uniprot_id": "DTWD2_MOUSE", "mass": 33102.0, "length": 298, "protein_name": "tRNA-uridine aminocarboxypropyltransferase 2", "gene_name": "Dtwd2", "organism": "Mouse", "refseq_name": "tRNA-uridine aminocarboxypropyltransferase 2 isoform 2", "refseq_ac": "NP_001164431", "gene_names_uniprotkb": "Dtwd2", "gene_names_refseq": "1190002H09Rik; 8030470C17Rik; Dtwd2", "protein_names_uniprotkb": "tRNA-uridine aminocarboxypropyltransferase 2; 2.5.1.25; DTW domain-containing protein 2", "protein_names_refseq": "DTW domain-containing protein 2; tRNA-uridine aminocarboxypropyltransferase 2 isoform 2; tRNA-uridine aminocarboxypropyltransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68857)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20485683;21750661", "class_list": "", "function": "Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)). Involved in glycoRNA biosynthesis by mediating formation of acp3U, which acts as an attachment site for N-glycans on tRNAs. GlycoRNAs consist of RNAs modified with secretory N-glycans that are presented on the cell surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.25", "go_molecular_function": "GO:0016432 tRNA-uridine aminocarboxypropyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006400 tRNA modification;GO:0141217 glycoRNA biosynthetic process;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0U1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3N2-1", "uniprot_id": "CLXN_MOUSE", "mass": 24606.0, "length": 212, "protein_name": "Calaxin", "gene_name": "Clxn", "organism": "Mouse", "refseq_name": "calaxin", "refseq_ac": "NP_080045", "gene_names_uniprotkb": "Clxn; Efcab1", "gene_names_refseq": "4930449A16Rik; 5430404L10Rik; Clxn; Efcab1", "protein_names_uniprotkb": "Calaxin; EF-hand calcium-binding domain-containing protein 1", "protein_names_refseq": "EF-hand calcium binding domain 1; EF-hand calcium-binding domain-containing protein 1; calaxin", "tax_id": 10090, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:66793)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31240264;36727596", "class_list": "", "function": "Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality (PubMed:31240264)., [UniProtKB, UniProtKB, PubMed]; Mice with a null mutation in Efcab1 display typical phenotypes of primary ciliary dyskinesia, including hydrocephalus, situs inversus, and abnormal motility of trachea cilia and sperm flagella. Strikingly, both males and females are viable and fertile, indicating that calaxin is not essential for fertilization in mice. The 9 + 2 axonemal structures of epithelial multicilia and sperm flagella are normal. Erratum:[Commun Biol. 2019 Jul 4;2:254. doi: 10.1038/s42003-019-0512-5. PMID: 31286071] Publication Status: Online-Only, [RefSeq, PubMed]; Pathogenic variants in CLXN encoding the outer dynein arm docking-associated calcium-binding protein calaxin cause primary ciliary dyskinesia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSW3;Q8C982;Q8CAI0;Q9D527;Q9D5E7", "ec_number_list": "", "go_molecular_function": "GO:0120152 calcium-dependent outer dynein arm binding;GO:0005509 calcium ion binding;GO:0048487 beta-tubulin binding;GO:0045504 dynein heavy chain binding;GO:0140659 cytoskeletal motor regulator activity", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0009966 regulation of signal transduction;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:0003352 regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4C5-1", "uniprot_id": "EAF1_MOUSE", "mass": 28967.0, "length": 268, "protein_name": "ELL-associated factor 1", "gene_name": "Eaf1", "organism": "Mouse", "refseq_name": "ELL-associated factor 1", "refseq_ac": "NP_083208", "gene_names_uniprotkb": "Eaf1", "gene_names_refseq": "4933403C17Rik; Eaf1", "protein_names_uniprotkb": "ELL-associated factor 1", "protein_names_refseq": "ELL-associated factor 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:74427); (R-MMU-112382); (R-MMU-674695); (R-MMU-75955)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;26495903;31229879;35820727", "class_list": "", "function": "Acts as a transcriptional transactivator of ELL and ELL2 elongation activities., [UniProtKB]; Loss of Eaf1 murine prostate can induce pre-neoplastic PIN lesions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck;GO:0045171 intercellular bridge", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D4C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D581-1", "uniprot_id": "EFC10_MOUSE", "mass": 15562.0, "length": 132, "protein_name": "EF-hand calcium-binding domain-containing protein 10", "gene_name": "Efcab10", "organism": "Mouse", "refseq_name": "EF-hand calcium-binding domain-containing protein 10", "refseq_ac": "NP_083428", "gene_names_uniprotkb": "Efcab10", "gene_names_refseq": "4930504H06Rik; Efcab10", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 10", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:75040)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;25428506", "class_list": "", "function": "4930504H06Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBZ5-1", "uniprot_id": "EIF3K_MOUSE", "mass": 25087.0, "length": 218, "protein_name": "Eukaryotic translation initiation factor 3 subunit K", "gene_name": "Eif3k", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit K isoform 2", "refseq_ac": "NP_001272871", "gene_names_uniprotkb": "Eif3k; Eif3s12", "gene_names_refseq": "1200009C21Rik; Eif3k; Eif3s12", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit K; Eukaryotic translation initiation factor 3 subunit 12; eIF-3 p25; eIF3k", "protein_names_refseq": "eIF-3 p25; eukaryotic translation initiation factor 3 subunit K isoform 2; eukaryotic translation initiation factor 3, subunit 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:73830); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "17581632;18250455;18299400;19224205;20173027;21750661;25428507;25605945;34428180;35820727;37828378;39627609", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58EU9;Q8K3A1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9DBZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ET22-1", "uniprot_id": "DPP2_MOUSE", "mass": 56254.0, "length": 506, "protein_name": "Dipeptidyl peptidase 2", "gene_name": "Dpp7", "organism": "Mouse", "refseq_name": "dipeptidyl peptidase 2 isoform 1 precursor", "refseq_ac": "NP_114031", "gene_names_uniprotkb": "Dpp7; Dpp2; Qpp", "gene_names_refseq": "DPPII; Dpp2; Dpp7; QPP", "protein_names_uniprotkb": "Dipeptidyl peptidase 2; 3.4.14.2; DPP II; Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; Quiescent cell proline dipeptidase", "protein_names_refseq": "DPP II; dipeptidyl aminopeptidase II; dipeptidyl peptidase 2 isoform 1 precursor; dipeptidyl peptidase 2; dipeptidyl peptidase II; quiescent cell proline dipeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:83768); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18555530;19819973;21469121;26495903;30899004;35820727", "class_list": "", "function": "Data show that an increase in food intake in DPP2 kd mice, which was associated with a significant increase in adipose tissue mass and enhanced liver steatosis but no difference in body weight., [RefSeq, PubMed]; Gene deficiency results in Th17 differentiation and peripheral T cells hyperactivation upon TCR stimulation, [RefSeq, PubMed]; KLF2 and TOB1 activate the mouse Dpp2 promoter., [RefSeq, PubMed]; Plays an important role in the degradation of some oligopeptides., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8R082", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0070008 serine-type exopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle;GO:0031982 vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ET22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLJ5-1", "uniprot_id": "ELOV1_MOUSE", "mass": 32678.0, "length": 279, "protein_name": "Very long chain fatty acid elongase 1", "gene_name": "Elovl1", "organism": "Mouse", "refseq_name": "very long chain fatty acid elongase 1 isoform 2", "refseq_ac": "NP_001034264", "gene_names_uniprotkb": "Elovl1; Ssc1", "gene_names_refseq": "Elovl1; Ssc1", "protein_names_uniprotkb": "Very long chain fatty acid elongase 1; 2.3.1.199; 3-keto acyl-CoA synthase Elovl1; ELOVL FA elongase 1; ELOVL fatty acid elongase 1; Elongation of very long chain fatty acids protein 1; Very long chain 3-ketoacyl-CoA synthase 1; Very long chain 3-oxoacyl-CoA synthase 1", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl1; ELOVL FA elongase 1; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1; elongation of very long chain fatty acids protein 1; sequence similarity to Cig30 1; very long chain 3-ketoacyl-CoA synthase 1; very long chain 3-oxoacyl-CoA synthase 1; very long chain fatty acid elongase 1 isoform 2; very long chain fatty acid elongase 1", "tax_id": 10090, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (mmu:54325); (R-MMU-2046105); (R-MMU-2046106); (R-MMU-75876)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10791983;11891222;20937905;23407971;23689133;25153642;25428506;30084848;31219806;33069870;34428180;40997131", "class_list": "glycogene", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed]; Elucidation of structure and regulation, [RefSeq, PubMed]; Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1B2", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JLJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMG1-1", "uniprot_id": "EDF1_MOUSE", "mass": 16369.0, "length": 148, "protein_name": "Endothelial differentiation-related factor 1", "gene_name": "Edf1", "organism": "Mouse", "refseq_name": "endothelial differentiation-related factor 1", "refseq_ac": "NP_067494", "gene_names_uniprotkb": "Edf1", "gene_names_refseq": "0610008L11Rik; Edf1; MBF1", "protein_names_uniprotkb": "Endothelial differentiation-related factor 1; EDF-1; MBF1; Multiprotein-bridging factor 1", "protein_names_refseq": "endothelial differentiation-related factor 1; hypothetical protein 1-9; multiprotein-bridging factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:59022)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10679242;11587857;16452087;19224205;19554257;20173027;23376715;25428506;26495903;28011936;30084848;31599954;34428180;35820727", "class_list": "", "function": "EDF-1 is required for PPARgamma transcriptional activation during preadipocyte differentiation., [RefSeq, PubMed]; These results showed that EDF-1 inactivates the calmodulin/calcineurin/NFAT pathway via sequestration of calmodulin, during early adipogenesis., [RefSeq, PubMed]; Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99NE6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0005516 calmodulin binding;GO:0001094 TFIID-class transcription factor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JMG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMI0-1", "uniprot_id": "ECEL1_MOUSE", "mass": 87993.0, "length": 775, "protein_name": "Endothelin-converting enzyme-like 1", "gene_name": "Ecel1", "organism": "Mouse", "refseq_name": "endothelin-converting enzyme-like 1", "refseq_ac": "NP_001264854", "gene_names_uniprotkb": "Ecel1; Dine; Xce", "gene_names_refseq": "DINE; Ecel1; xce", "protein_names_uniprotkb": "Endothelin-converting enzyme-like 1; 3.4.24.-; Damage-induced neuronal endopeptidase; Xce protein", "protein_names_refseq": "damage-induced neuronal endopeptidase; endothelin-converting enzyme-like 1", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); distal arthrogryposis type 5D (Disease Ontology:DOID:0111594)", "pathway": " (mmu:13599)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10400672;10759559;18192274;20484637;23261301;31219806;38170441", "class_list": "", "function": "Brachial Plexus Root Avulsion Injury-Induced Endothelin-Converting Enzyme-Like 1 Overexpression Is Associated with Injured Motor Neurons Survival., [RefSeq, PubMed]; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides., [UniProtKB]; Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the requisite synergistic effect in neuronal injury through DINE neuronal injury-inducible gene, [RefSeq, PubMed]; The data of this study suggested that DINE is a crucial molecule in distal axonal arborization into muscle to establish neuromuscular junctions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFG4", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003016 respiratory system process;GO:0007218 neuropeptide signaling pathway;GO:0016485 protein processing;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JMI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX66-1", "uniprot_id": "DPF1_MOUSE", "mass": 44239.0, "length": 387, "protein_name": "Zinc finger protein neuro-d4", "gene_name": "Dpf1", "organism": "Mouse", "refseq_name": "zinc finger protein neuro-d4 isoform 1", "refseq_ac": "NP_038902", "gene_names_uniprotkb": "Dpf1; Baf45b; Neud4", "gene_names_refseq": "Dpf1; Neud4", "protein_names_uniprotkb": "Zinc finger protein neuro-d4; BAF45B; BRG1-associated factor 45B; D4, zinc and double PHD fingers family 1", "protein_names_refseq": "BAF45B; BRG1-associated factor 45B; D4, zinc and double PHD fingers family 1; neuronal d4 domain family member; zinc finger protein neuro-d4 isoform 1; zinc finger protein neuro-d4", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:29861); (R-MMU-9933937)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10602997;17640523;21750661;27802388;31219806", "class_list": "", "function": "May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QX65;Q9QYA4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071565 nBAF complex;GO:0000785 chromatin;GO:0005634 nucleus", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QX66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYJ3-1", "uniprot_id": "DNJB1_MOUSE", "mass": 38167.0, "length": 340, "protein_name": "DnaJ homolog subfamily B member 1", "gene_name": "Dnajb1", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 1 isoform 1", "refseq_ac": "NP_061278", "gene_names_uniprotkb": "Dnajb1; Hsp40; Hspf1", "gene_names_refseq": "0610007I11Rik; DjB1; Dnajb1; HSPF1; Hdj1; Hsp40", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 1; HSP40; Heat shock 40 kDa protein 1; Heat shock protein 40", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 1; dnaJ homolog subfamily B member 1 isoform 1; dnaJ homolog subfamily B member 1; heat shock 40 kDa protein 1", "tax_id": 10090, "disease": "congenital myopathy 21 (Disease Ontology:DOID:0081353); autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (mmu:81489); (R-MMU-3371453); (R-MMU-3371497); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-5687128)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10570961;11092732;22645316;28531192;28923495;29162699;34428180;37859693", "class_list": "", "function": "Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Generation of the Dnajb1-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma., [RefSeq, PubMed]; Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)., [UniProtKB, UniProtKB]; Overexpression of DNAJB1 relieves TDP-43 mediated toxicity in primary rodent cortical neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Study validates the DNAJB1-PRKACA fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin., [RefSeq, PubMed]; This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; This is a paper that uses purification techiques to find the following: Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding;GO:0003714 transcription corepressor activity;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0061827 sperm head;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:1903334 positive regulation of protein folding;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QYJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUF2-1", "uniprot_id": "EGR4_MOUSE", "mass": 49554.0, "length": 478, "protein_name": "Early growth response protein 4", "gene_name": "Egr4", "organism": "Mouse", "refseq_name": "early growth response protein 4", "refseq_ac": "NP_065621", "gene_names_uniprotkb": "Egr4", "gene_names_refseq": "Egr4; NGF1-C; NGFI-C; NGFIC; pAT133", "protein_names_uniprotkb": "Early growth response protein 4; EGR-4", "protein_names_refseq": "EGR-4; early growth response protein 4", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:13656)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10529423;32212315", "class_list": "", "function": "Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo., [RefSeq, PubMed]; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WUF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9S1-1", "uniprot_id": "EVG1_MOUSE", "mass": 24737.0, "length": 216, "protein_name": "UPF0193 protein EVG1 homolog", "gene_name": "1700088E04Rik", "organism": "Mouse", "refseq_name": "UPF0193 protein EVG1 homolog isoform 2", "refseq_ac": "NP_001297505", "gene_names_uniprotkb": "1700088E04Rik", "gene_names_refseq": "1700088E04Rik; ESTJ0827E04", "protein_names_uniprotkb": "UPF0193 protein EVG1 homolog", "protein_names_refseq": "UPF0193 protein EVG1 homolog isoform 2; UPF0193 protein EVG1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:27660)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUD8-1", "uniprot_id": "FAIM1_MOUSE", "mass": 20201.0, "length": 179, "protein_name": "Fas apoptotic inhibitory molecule 1", "gene_name": "Faim", "organism": "Mouse", "refseq_name": "fas apoptotic inhibitory molecule 1 isoform Faim-L", "refseq_ac": "NP_001116323", "gene_names_uniprotkb": "Faim; Faim1", "gene_names_refseq": "Faim", "protein_names_uniprotkb": "Fas apoptotic inhibitory molecule 1", "protein_names_refseq": "fas apoptotic inhibitory molecule 1 isoform Faim-L; fas apoptotic inhibitory molecule 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23873)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10075978;16479539;19168072;21750661;25428506;30084848;30779550;31219806;32015347;34203471;34428180;34713467;36055580;36210013;36766830", "class_list": "", "function": "Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina., [RefSeq, PubMed]; PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRbeta axis during overnutrition., [RefSeq, PubMed]; Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Publication Status: Online-Only, [RefSeq, PubMed]; The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAK6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0050769 positive regulation of neurogenesis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WUD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBV3-1", "uniprot_id": "EXOS2_MOUSE", "mass": 32632.0, "length": 293, "protein_name": "Exosome complex component RRP4", "gene_name": "Exosc2", "organism": "Mouse", "refseq_name": "exosome complex component RRP4", "refseq_ac": "NP_659135", "gene_names_uniprotkb": "Exosc2; Rrp4", "gene_names_refseq": "Exosc2; Rrp4", "protein_names_uniprotkb": "Exosome complex component RRP4; Exosome component 2; Ribosomal RNA-processing protein 4", "protein_names_refseq": "exosome complex component RRP4; exosome complex exonuclease RRP4; homolog of Yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease", "tax_id": 10090, "disease": "short stature, hearing loss, retinitis pigmentosa, and distinctive facies (Disease Ontology:DOID:0081175); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:227715); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006396 RNA processing;GO:0030307 positive regulation of cell growth;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006401 RNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VBV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08716-1", "uniprot_id": "FABP9_MOUSE", "mass": 15017.0, "length": 132, "protein_name": "Fatty acid-binding protein 9", "gene_name": "Fabp9", "organism": "Mouse", "refseq_name": "fatty acid-binding protein 9", "refseq_ac": "NP_035728", "gene_names_uniprotkb": "Fabp9; Perf15; Tlbp", "gene_names_refseq": "1700007P10Rik; Fabp9; Perf15; Perf; Tlbp", "protein_names_uniprotkb": "Fatty acid-binding protein 9; 15 kDa perforatorial protein; PERF 15; T-FABP; TLBP; Testis lipid-binding protein; Testis-type fatty acid-binding protein", "protein_names_refseq": "15 kDa perforatorial protein; PERF 15; T-FABP; fatty acid-binding protein 9; testis lipid-binding protein; testis-type fatty acid-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:21884); (R-MMU-163560)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20920498;21750661;9408250", "class_list": "", "function": "FABP9 plays only a minor role in providing the murine sperm head its characteristic shape and is not absolutely required for spermatogenesis or sperm function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAL2", "ec_number_list": "", "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0015909 long-chain fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1KXC4-1", "uniprot_id": "FCMR_MOUSE", "mass": 47471.0, "length": 422, "protein_name": "Immunoglobulin mu Fc receptor", "gene_name": "Fcmr", "organism": "Mouse", "refseq_name": "immunoglobulin mu Fc receptor isoform 1 precursor", "refseq_ac": "NP_081252", "gene_names_uniprotkb": "Fcmr; Faim3; Toso", "gene_names_refseq": "1810037B05Rik; Faim3; Fcmr; FcmuR; IgM FcR; Toso", "protein_names_uniprotkb": "Immunoglobulin mu Fc receptor; FAIM3; Fas apoptotic inhibitory molecule 3; IgM FcR; Regulator of Fas-induced apoptosis Toso", "protein_names_refseq": "Fas apoptotic inhibitory molecule 3; IgM Fc fragment receptor; immunoglobulin mu Fc receptor isoform 1 precursor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso", "tax_id": 10090, "disease": "", "pathway": " (mmu:69169)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15632112;20042454;21750661;22988094;23267023;25732732;28011936;28135254;29187734;29461978;32152506;34788614", "class_list": "", "function": "High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (By similarity). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:28135254, PubMed:34788614). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (By similarity) (PubMed:22988094, PubMed:23267023, PubMed:25732732, PubMed:28135254, PubMed:29461978)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas ligand-induced apoptosis., [RefSeq, PubMed]; These results identify TOSO/FAIM3 as a receptor for IgM, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1KXC6;A1KXC8;A1KXC9;Q148B9;Q9D8T1", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001791 IgM binding;GO:0002172 high-affinity IgM receptor activity;GO:0001790 polymeric immunoglobulin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002414 immunoglobulin transcytosis in epithelial cells;GO:0070229 negative regulation of lymphocyte apoptotic process;GO:0007165 signal transduction;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A1KXC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZL2-1", "uniprot_id": "F241A_MOUSE", "mass": 14511.0, "length": 131, "protein_name": "Uncharacterized protein FAM241A", "gene_name": "Fam241a", "organism": "Mouse", "refseq_name": "uncharacterized protein FAM241A", "refseq_ac": "NP_081758", "gene_names_uniprotkb": "Fam241a; 5730508B09Rik", "gene_names_refseq": "2700063A17Rik; 5730508B09Rik; Fam241a", "protein_names_uniprotkb": "Uncharacterized protein FAM241A", "protein_names_refseq": "uncharacterized protein C4orf32 homolog; uncharacterized protein FAM241A", "tax_id": 10090, "disease": "", "pathway": " (mmu:70617)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D650-1", "uniprot_id": "LRAT1_MOUSE", "mass": 32676.0, "length": 292, "protein_name": "Protein LRATD1", "gene_name": "Lratd1", "organism": "Mouse", "refseq_name": "protein LRATD1", "refseq_ac": "NP_083283", "gene_names_uniprotkb": "Lratd1; Fam84a", "gene_names_refseq": "2310003N02Rik; 4731402F03Rik; Fam84a; Lratd1; Nse1", "protein_names_uniprotkb": "Protein LRATD1; LRAT domain-containing 1; Protein FAM84A", "protein_names_refseq": "family with sequence similarity 84, member A; protein FAM84A; protein LRATD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:105005)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16820875;21424122;21750661;34428180", "class_list": "", "function": "FAM84A is up-regulated by CAR during the development of liver tumors., [RefSeq, PubMed]; May play a role in cell morphology and motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99K34", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D650-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35912-1", "uniprot_id": "EMP3_MOUSE", "mass": 18253.0, "length": 163, "protein_name": "Epithelial membrane protein 3", "gene_name": "Emp3", "organism": "Mouse", "refseq_name": "epithelial membrane protein 3", "refseq_ac": "NP_001139818", "gene_names_uniprotkb": "Emp3; Ymp", "gene_names_refseq": "Emp3; H-4; H4; HNMP-1; MI-35; Ymp", "protein_names_uniprotkb": "Epithelial membrane protein 3; EMP-3; HNMP-1; Hematopoietic neural membrane protein 1; Protein YMP", "protein_names_refseq": "EMP-3; epithelial membrane protein 3; hematopoietic neural membrane protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13732)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12734360;12845499;21750661;29269102;30084848;34428180;9204931;9615230", "class_list": "", "function": "Probably involved in cell proliferation and cell-cell interactions., [UniProtKB]; Results suggest that Emp3 in allogeneic APCs possesses the inhibitory function of alloreactive CTL induction by downregulation of IL-2Ralpha expression CD8(+) T cells via an increase in TNF-alpha production., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88333;Q3UIF8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0032060 bleb assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35912-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JH8-1", "uniprot_id": "ERD21_MOUSE", "mass": 24560.0, "length": 212, "protein_name": "ER lumen protein-retaining receptor 1", "gene_name": "Kdelr1", "organism": "Mouse", "refseq_name": "ER lumen protein-retaining receptor 1", "refseq_ac": "NP_598711", "gene_names_uniprotkb": "Kdelr1", "gene_names_refseq": "8030486F04Rik; Erd2.1; Kdelr1", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1", "protein_names_refseq": "ER lumen protein-retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68137); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15340063;21750661;26438836;26489882;34428180", "class_list": "", "function": "Dilated cardiomyopathy found in the mutant KDEL receptor transgenic mice is associated with ER stress, [RefSeq, PubMed]; In a mouse line having nonfunctional KDELR1, polyclonal naive T cells show excessive integrated stress responses, which are rescued by strong TCR-mediated signaling, [RefSeq, PubMed]; Present a recessive mouse missense allele of the prototypical mammalian KDEL receptor, KDEL ER protein retention receptor 1 (KDELR1). Kdelr1 homozygous mutants were mildly lymphopenic, as were mice with a CRISPR/Cas9-engineered frameshift allele, [RefSeq, PubMed]; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen;GO:0070231 T cell apoptotic process;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99JH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WE2-1", "uniprot_id": "PIP30_MOUSE", "mass": 28702.0, "length": 254, "protein_name": "PSME3-interacting protein", "gene_name": "Psme3ip1", "organism": "Mouse", "refseq_name": "PSME3-interacting protein isoform a", "refseq_ac": "NP_082497", "gene_names_uniprotkb": "Psme3ip1; Fam192a; Nip30", "gene_names_refseq": "1700001O11Rik; 2310065K24Rik; Fam192a; Nip30; Psme3ip1", "protein_names_uniprotkb": "PSME3-interacting protein; NEFA-interacting nuclear protein NIP30; PA28G-interacting protein", "protein_names_refseq": "NEFA-interacting nuclear protein NIP30; PA28G-interacting protein; PSME3-interacting protein isoform a; PSME3-interacting protein; family with sequence similarity 192, member A; protein FAM192A", "tax_id": 10090, "disease": "", "pathway": " (mmu:102122)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;26497270;28135057;28528544;32764536", "class_list": "", "function": "Nip30 is expressed in skeletal muscle.Nip30 and Rspry1 common promoter region contains a conserved E-box element. Nip30 localizes to the nucleus., [RefSeq, PubMed]; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus., [UniProtKB, UniProtKB]; The REGgamma inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Erratum:[Nat Commun. 2020 Sep 23;11(1):4888. doi: 10.1038/s41467-020-18767-0. PMID: 32968062] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9X3;Q8R0C9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0032091 negative regulation of protein binding;GO:1901799 negative regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91WE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23953-1", "uniprot_id": "EST1C_MOUSE", "mass": 61056.0, "length": 554, "protein_name": "Carboxylesterase 1C", "gene_name": "Ces1c", "organism": "Mouse", "refseq_name": "carboxylesterase 1C precursor", "refseq_ac": "NP_031980", "gene_names_uniprotkb": "Ces1c; Es1", "gene_names_refseq": "Ces-N; Ces1c; Ee-1; Ee1; Es-4; Es-N; Es1; Es4; EsN; PESN", "protein_names_uniprotkb": "Carboxylesterase 1C; 3.1.1.1; Liver carboxylesterase N; Lung surfactant convertase; PES-N", "protein_names_refseq": "PES-N; carboxylesterase 1C precursor; esterase 1; liver carboxylesterase N; lung surfactant convertase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stomach cancer (Disease Ontology:DOID:10534); gastrointestinal system cancer (Disease Ontology:DOID:3119); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13884)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17330941;1840565;20571061;21750661;25428506;26495903;26740625;2895647;37267638;37507081;39627609;39927985;9815115", "class_list": "", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant., [UniProtKB]; Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ07;O54936;P11374;Q8K125", "ec_number_list": "3.1.1.1;3.1.1.-;3.1.1.13;3.1.1.67", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0016788 hydrolase activity, acting on ester bonds;GO:0042803 protein homodimerization activity;GO:0050253 retinyl-palmitate esterase activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet", "go_biological_process": "GO:0009617 response to bacterium;GO:0019626 short-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P23953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C522-1", "uniprot_id": "ENDD1_MOUSE", "mass": 55262.0, "length": 501, "protein_name": "Endonuclease domain-containing 1 protein", "gene_name": "Endod1", "organism": "Mouse", "refseq_name": "endonuclease domain-containing 1 protein precursor", "refseq_ac": "NP_082289", "gene_names_uniprotkb": "Endod1; Kiaa0830", "gene_names_refseq": "2210414F18Rik; 2310067E08Rik; Endod1", "protein_names_uniprotkb": "Endonuclease domain-containing 1 protein; 3.1.30.-", "protein_names_refseq": "endonuclease domain-containing 1 protein precursor; endonuclease domain-containing 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71946); (R-MMU-114608)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;30084848;30779550;35606358", "class_list": "", "function": "May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26., [UniProtKB, UniProtKB]; Synthetic lethality between TP53 and ENDOD1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA96;Q8C5M1;Q8VE35", "ec_number_list": "1.8.-.-;1.15.1.1;3.6.4.-;3.6.5.-;3.1.30.-", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C522-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57791-1", "uniprot_id": "FACE2_MOUSE", "mass": 35867.0, "length": 329, "protein_name": "CAAX prenyl protease 2", "gene_name": "Rce1", "organism": "Mouse", "refseq_name": "CAAX prenyl protease 2 isoform b", "refseq_ac": "NP_075620", "gene_names_uniprotkb": "Rce1; Face2; Rce1a", "gene_names_refseq": "D19Ertd283e; D19Ertd98e; Rce1", "protein_names_uniprotkb": "CAAX prenyl protease 2; 3.4.26.1; FACE-2; Farnesylated proteins-converting enzyme 2; Prenyl protein-specific endoprotease 2; RCE1 homolog", "protein_names_refseq": "CAAX prenyl protease 2 isoform b; CAAX prenyl protease 2; FACE-2; RCE1 homolog, prenyl protein peptidase; Ras and a-factor-converting enzyme 1 homolog; farnesylated proteins-converting enzyme 2; prenyl protein-specific endoprotease 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19671); (R-MMU-5689880); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10085069;21750661;32398789", "class_list": "", "function": "Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b., [RefSeq, PubMed]; Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSF8;Q9EP68", "ec_number_list": "3.4.19.12;3.6.5.2;3.1.3.48;3.4.26.1;3.6.4.13", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008238 exopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071586 CAAX-box protein processing;GO:0080120 CAAX-box protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P57791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59900-1", "uniprot_id": "EMIL3_MOUSE", "mass": 82396.0, "length": 758, "protein_name": "EMILIN-3", "gene_name": "Emilin3", "organism": "Mouse", "refseq_name": "EMILIN-3 isoform b precursor", "refseq_ac": "NP_001278074", "gene_names_uniprotkb": "Emilin3; Emilin5", "gene_names_refseq": "1110013O17Rik; EMILIN-3; EMILIN-5; EMILIN-T; Emilin3; Emilin5", "protein_names_uniprotkb": "EMILIN-3; EMILIN-5; Elastin microfibril interface located protein 5; Elastin microfibril interface-located protein 3; Elastin microfibril interfacer 3; Elastin microfibril interfacer 5", "protein_names_refseq": "EMILIN-3 isoform b precursor; elastin microfibril interface located protein 5; elastin microfibril interface-located protein 3; elastin microfibril interfacer 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:280635); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12221002;14706625;17660561;21750661;22334695;25428506;27892605", "class_list": "", "function": "Characterization of the expression and biochemical properties of EMILIN-3, [RefSeq, PubMed]; Dispensable for hair follicle growth and maintenance, [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:1990971 EMILIN complex;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P59900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ARK0-1", "uniprot_id": "FA83C_MOUSE", "mass": 84071.0, "length": 776, "protein_name": "Protein FAM83C", "gene_name": "Fam83c", "organism": "Mouse", "refseq_name": "protein FAM83C", "refseq_ac": "NP_082064", "gene_names_uniprotkb": "Fam83c", "gene_names_refseq": "5530400B04Rik; Fam83c; Sack1c", "protein_names_uniprotkb": "Protein FAM83C", "protein_names_refseq": "ortholog of family with sequence similarity 83, member C FAM83C (5530400B04Rik); protein FAM83C", "tax_id": 10090, "disease": "", "pathway": " (mmu:71405)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in MAPK signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14CG2", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ARK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78T81-1", "uniprot_id": "EEIG1_MOUSE", "mass": 42830.0, "length": 392, "protein_name": "Early estrogen-induced gene 1 protein", "gene_name": "Eeig1", "organism": "Mouse", "refseq_name": "early estrogen-induced gene 1 protein", "refseq_ac": "NP_705788", "gene_names_uniprotkb": "Eeig1; Fam102a", "gene_names_refseq": "C230093N12Rik; Eeig1; Fam102a", "protein_names_uniprotkb": "Early estrogen-induced gene 1 protein; EEIG1", "protein_names_refseq": "early estrogen-induced gene 1 protein; family with sequence similarity 102, member A; protein FAM102A", "tax_id": 10090, "disease": "", "pathway": " (mmu:98952)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22645316;23478294;31219806;32741026;34428180;36210013", "class_list": "", "function": "Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression., [RefSeq, PubMed]; Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (PubMed:23478294, PubMed:32741026). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downstream transcription of NFATC1 and activation of PLCG2 (PubMed:23478294). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (PubMed:32741026). May play a role in estrogen action (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2K5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045121 membrane raft", "go_biological_process": "GO:0045672 positive regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q78T81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64695-1", "uniprot_id": "EPCR_MOUSE", "mass": 27189.0, "length": 242, "protein_name": "Endothelial protein C receptor", "gene_name": "Procr", "organism": "Mouse", "refseq_name": "endothelial protein C receptor isoform a precursor", "refseq_ac": "NP_035301", "gene_names_uniprotkb": "Procr; Epcr", "gene_names_refseq": "Ccca; Ccd41; Epcr; Procr", "protein_names_uniprotkb": "Endothelial protein C receptor; APC receptor; Activated protein C receptor; Centrocyclin; Centrosomal protein CCD41; Endothelial cell protein C receptor", "protein_names_refseq": "APC receptor; CD antigen CD201; activated protein C receptor; centrocyclin; centrosomal protein CCD41; endothelial cell protein C receptor; endothelial protein C receptor isoform a precursor; endothelial protein C receptor", "tax_id": 10090, "disease": "malaria (Disease Ontology:DOID:12365); carotid stenosis (Disease Ontology:DOID:13001); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (mmu:19124); (R-MMU-202733); (R-MMU-9769739)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10235444;21750661;34428180;38279255;39442966;7890676;8449997", "class_list": "", "function": "Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation., [UniProtKB]; Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model. Publication Status: Online-Only, [RefSeq, PubMed]; [The role of protein C receptor (PROCR) in the whole glucan particle (WGP) induced maturation of mouse bone marrow-derived dendritic cells]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q4FK76;Q9WV33", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005813 centrosome;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007596 blood coagulation;GO:0050819 negative regulation of coagulation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BDP1-1", "uniprot_id": "NALF2_MOUSE", "mass": 52389.0, "length": 471, "protein_name": "NALCN channel auxiliary factor 2", "gene_name": "Nalf2", "organism": "Mouse", "refseq_name": "NALCN channel auxiliary factor 2", "refseq_ac": "NP_001074752", "gene_names_uniprotkb": "Nalf2; Fam155b; Tmem28", "gene_names_refseq": "EG620592; Fam155b; Nalf2; Tmem28; Tnen28", "protein_names_uniprotkb": "NALCN channel auxiliary factor 2; Protein TED; Transmembrane protein 28; Transmembrane protein FAM155B", "protein_names_refseq": "NALCN channel auxiliary factor 2; likely orthologue of H. sapiens transmembrane protein 28 (TMEM28); transmembrane protein FAM155B", "tax_id": 10090, "disease": "", "pathway": " (mmu:620592)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "Probable component of the NALCN channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BDP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UXZ6-1", "uniprot_id": "FA81A_MOUSE", "mass": 41710.0, "length": 364, "protein_name": "Protein FAM81A", "gene_name": "Fam81a", "organism": "Mouse", "refseq_name": "protein FAM81A isoform 1", "refseq_ac": "NP_084060", "gene_names_uniprotkb": "Fam81a", "gene_names_refseq": "6430514L14Rik; Fam81a", "protein_names_uniprotkb": "Protein FAM81A", "protein_names_refseq": "protein FAM81A isoform 1; protein FAM81A", "tax_id": 10090, "disease": "", "pathway": " (mmu:76886)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30735723;38452102", "class_list": "", "function": "Facilitates the interaction and assembly of proteins within the postsynaptic density by promoting the condensation of postsynaptic proteins via liquid-liquid phase separation (PubMed:38452102). Required for neuronal activity (PubMed:38452102). Accumulation at the postsynaptic density results in enlargement of dendritic spines (PubMed:38452102)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQV1;Q8C548;Q8R3B5;Q9D369", "ec_number_list": "", "go_molecular_function": "GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UXZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6I7-1", "uniprot_id": "DIK1A_MOUSE", "mass": 48936.0, "length": 428, "protein_name": "Divergent protein kinase domain 1A", "gene_name": "Dipk1a", "organism": "Mouse", "refseq_name": "divergent protein kinase domain 1A", "refseq_ac": "NP_080338", "gene_names_uniprotkb": "Dipk1a; Fam69a", "gene_names_refseq": "2900024C23Rik; Dipk1a; Fam69a", "protein_names_uniprotkb": "Divergent protein kinase domain 1A; Protein FAM69A", "protein_names_refseq": "divergent protein kinase domain 1A; family with sequence similarity 69, member A; protein FAM69A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67266)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21334309;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5P1;Q3V308", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D6I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0Z1-1", "uniprot_id": "F234A_MOUSE", "mass": 60576.0, "length": 555, "protein_name": "Protein FAM234A", "gene_name": "Fam234a", "organism": "Mouse", "refseq_name": "protein FAM234A isoform 1", "refseq_ac": "NP_001193264", "gene_names_uniprotkb": "Fam234a; Itfg3", "gene_names_refseq": "Fam234a; Itfg3", "protein_names_uniprotkb": "Protein FAM234A; Protein ITFG3", "protein_names_refseq": "protein FAM234A isoform 1; protein FAM234A; protein ITFG3", "tax_id": 10090, "disease": "", "pathway": " (mmu:106581)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19349973;19656770;21750661;30899004;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ74", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8C0Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z6S9-1", "uniprot_id": "ERIP6_MOUSE", "mass": 80949.0, "length": 713, "protein_name": "Glutamate-rich protein 6", "gene_name": "Erich6", "organism": "Mouse", "refseq_name": "glutamate-rich protein 6", "refseq_ac": "NP_001074731", "gene_names_uniprotkb": "Erich6; Fam194a", "gene_names_refseq": "4932431H17Rik; Erich6; Fam194a", "protein_names_uniprotkb": "Glutamate-rich protein 6; Protein FAM194A", "protein_names_refseq": "family with sequence similarity 194, member A; glutamate-rich protein 6; protein FAM194A", "tax_id": 10090, "disease": "", "pathway": " (mmu:545527)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z6S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97464-1", "uniprot_id": "EXT1_MOUSE", "mass": 86308.0, "length": 746, "protein_name": "Exostosin-1", "gene_name": "Ext1", "organism": "Mouse", "refseq_name": "exostosin-1", "refseq_ac": "NP_034292", "gene_names_uniprotkb": "Ext1", "gene_names_refseq": "Ext1", "protein_names_uniprotkb": "Exostosin-1; 2.4.1.225; Exostosin glycosyltransferase 1; Multiple exostoses protein 1 homolog; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase", "protein_names_refseq": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; exostoses (multiple) 1; exostosin-1; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N- acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; multiple exostoses protein 1 homolog", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994); chondrosarcoma (Disease Ontology:DOID:3371)", "pathway": " (mmu:14042); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;31599954;34428180;9186511;9254013;9703997", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61546", "ec_number_list": "2.4.1.224;2.4.1.225", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0051923 sulfation;GO:0060429 epithelium development;GO:0043931 ossification involved in bone maturation;GO:0000271 polysaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97464-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55772-1", "uniprot_id": "ENTP1_MOUSE", "mass": 57205.0, "length": 510, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 1", "gene_name": "Entpd1", "organism": "Mouse", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 1 isoform 2", "refseq_ac": "NP_033978", "gene_names_uniprotkb": "Entpd1; Cd39", "gene_names_refseq": "2610206B08Rik; ATP-DPH; Cd39; E130009M23Rik; Entpd1; NTPDase-1", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 1; 3.6.1.5; ATP diphosphohydrolase; ATP-DPH; ATPDase; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; NTPDase 1; NTPDase1; Nucleoside triphosphate diphosphohydrolase 1", "protein_names_refseq": "CD39 antigen; NTPDase 1; NTPDase1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ecto-ATPase 1; ectoapyrase; ectonucleoside triphosphate diphosphohydrolase 1 isoform 2; lymphoid cell activation antigen; nucleoside triphosphate diphosphohydrolase 1", "tax_id": 10090, "disease": "hereditary spastic paraplegia 64 (Disease Ontology:DOID:0110815); pre-eclampsia (Disease Ontology:DOID:10591); hypothyroidism (Disease Ontology:DOID:1459); intrahepatic cholestasis (Disease Ontology:DOID:1852); transient cerebral ischemia (Disease Ontology:DOID:224); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (mmu:12495); (R-MMU-8850843)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;21913724;38545102;38683845;38953295;38975728;7930580;9730622", "class_list": "", "function": "CD39 Is Expressed on Functional Effector and Tissue-resident Memory CD8+ T Cells., [RefSeq, PubMed]; CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (By similarity). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (By similarity). This activity contributes to the regulation of extracellular levels of nucleotides (By similarity). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (By similarity)., [UniProtKB, UniProtKB]; Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates. This activity contributes to the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer., [RefSeq, PubMed]; Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.6.5.2;3.6.1.62;3.6.1.64;3.1.13.1;5.6.2.6;3.6.5.3;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;3.6.5.4;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.5.5;3.6.4.6;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;3.6.1.6;2.7.11.1;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.6.1.16;3.6.1.53;3.6.1.42", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0046032 ADP catabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030168 platelet activation;GO:0070527 platelet aggregation;GO:2001170 negative regulation of ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P55772-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQG7-1", "uniprot_id": "ENPP5_MOUSE", "mass": 54387.0, "length": 477, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "gene_name": "Enpp5", "organism": "Mouse", "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor", "refseq_ac": "NP_001162091", "gene_names_uniprotkb": "Enpp5", "gene_names_refseq": "D17Abb1e; E-NPP 5; Enpp5", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; 3.1.-.-; E-NPP 5; NPP-5", "protein_names_refseq": "ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor; ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:83965)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11027689;12927778;21750661;26740625;28898552;30899004;37828378;38436793", "class_list": "", "function": "Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (PubMed:28898552). Lacks lysopholipase D activity. May play a role in neuronal cell communication (By similarity)., [UniProtKB, UniProtKB, PubMed]; Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A9C479;Q921P7", "ec_number_list": "3.6.1.22;3.6.1.-;3.1.-.-", "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004551 dinucleotide phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0007154 cell communication;GO:0009166 nucleotide catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9EQG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1Z3-1", "uniprot_id": "ACKMT_MOUSE", "mass": 27397.0, "length": 247, "protein_name": "ATP synthase subunit C lysine N-methyltransferase", "gene_name": "Atpsckmt", "organism": "Mouse", "refseq_name": "ATP synthase subunit C lysine N-methyltransferase isoform 1", "refseq_ac": "NP_080822", "gene_names_uniprotkb": "Atpsckmt; Fam173b", "gene_names_refseq": "A930016P21Rik; Atpsckmt; Fam173b; mFam173b", "protein_names_uniprotkb": "ATP synthase subunit C lysine N-methyltransferase; 2.1.1.-; Protein N-lysine methyltransferase FAM173B; mFam173b", "protein_names_refseq": "ATP synthase subunit C lysine N-methyltransferase isoform 1; ATP synthase subunit C lysine N-methyltransferase; family with sequence similarity 173, member B; protein FAM173B; protein N-lysine methyltransferase FAM173B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68073)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29444090;30530489", "class_list": "", "function": "Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; We uncover a role for methyltransferase activity of FAM173B in the neurobiology of pain. These results also highlight FAM173B methyltransferase activity as a potential therapeutic target to treat debilitating chronic pain conditions Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2S1", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.372", "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030061 mitochondrial crista;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0018022 peptidyl-lysine methylation;GO:0018023 peptidyl-lysine trimethylation;GO:1904058 positive regulation of sensory perception of pain;GO:1905273 positive regulation of proton-transporting ATP synthase activity, rotational mechanism;GO:1905706 regulation of mitochondrial ATP synthesis coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1Z3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54754-1", "uniprot_id": "EPHB3_MOUSE", "mass": 109662.0, "length": 993, "protein_name": "Ephrin type-B receptor 3", "gene_name": "Ephb3", "organism": "Mouse", "refseq_name": "ephrin type-B receptor 3 precursor", "refseq_ac": "NP_034273", "gene_names_uniprotkb": "Ephb3; Etk2; Mdk5; Sek4", "gene_names_refseq": "Cek10; Ephb3; Etk2; HEK2; MDK5; Sek4; Tyro6; mDK-5", "protein_names_uniprotkb": "Ephrin type-B receptor 3; 2.7.10.1; Developmental kinase 5; Tyrosine-protein kinase receptor SEK-4; mDK-5", "protein_names_refseq": "developmental kinase 5; ephrin type-B receptor 3 precursor; ephrin type-B receptor 3; tyrosine-protein kinase receptor SEK-4", "tax_id": 10090, "disease": "malaria (Disease Ontology:DOID:12365)", "pathway": " (mmu:13845); (R-MMU-2682334); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10704386;12408869;14691139;15223334;19598115;21750661;27446912;37828378;38558087;38739682;7478528;7947319;8947026;9990854", "class_list": "", "function": "Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The lack of EphB3 receptor prevents bone loss in mouse models of osteoporosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62214;Q91YS9", "ec_number_list": "2.7.11.1;2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.13;3.4.24.24;2.7.10.4;3.4.24.35;3.4.23.-;2.7.1.40;3.6.4.-;3.6.5.2;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0008046 axon guidance receptor activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0001525 angiogenesis;GO:0016477 cell migration;GO:0048013 ephrin receptor signaling pathway;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P54754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54761-1", "uniprot_id": "EPHB4_MOUSE", "mass": 108848.0, "length": 987, "protein_name": "Ephrin type-B receptor 4", "gene_name": "Ephb4", "organism": "Mouse", "refseq_name": "ephrin type-B receptor 4 isoform b precursor", "refseq_ac": "NP_034274", "gene_names_uniprotkb": "Ephb4; Htk; Mdk2; Myk1", "gene_names_refseq": "Ephb4; Htk; MDK2; Myk1; Tyro11; b2b2412Clo", "protein_names_uniprotkb": "Ephrin type-B receptor 4; 2.7.10.1; Developmental kinase 2; Hepatoma transmembrane kinase; Tyrosine kinase MYK-1; mDK-2", "protein_names_refseq": "developmental kinase 2; ephrin type-B receptor 4 isoform b precursor; ephrin type-B receptor 4; hepatoma transmembrane kinase; mDK-2; tyrosine kinase MYK-1", "tax_id": 10090, "disease": "central conducting lymphatic anomaly (Disease Ontology:DOID:0081030); hemangiopericytoma (Disease Ontology:DOID:264); cystic kidney disease (Disease Ontology:DOID:2975); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lymphatic system disease (Disease Ontology:DOID:75)", "pathway": " (mmu:13846); (R-MMU-2682334); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10518221;11239002;19349973;19656770;21750661;27400125;27446912;29133876;31599954;37828378;7478528;8152808", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2, it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells (PubMed:10518221). Phosphorylates inactive tyrosine-protein kinase EPHB6 which promotes interaction of EPHB6 with SH2 domains, allowing it to recruit SH2 domain-containing signaling adapters (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q60627;Q99MR2", "ec_number_list": "2.7.11.1;2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.13;3.4.24.24;2.7.10.4;3.4.24.35;3.4.23.-;2.7.1.40;3.6.4.-;3.6.5.2;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0048013 ephrin receptor signaling pathway;GO:0003007 heart morphogenesis;GO:0002042 cell migration involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P54761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C163-1", "uniprot_id": "EXOG_MOUSE", "mass": 41384.0, "length": 368, "protein_name": "Nuclease EXOG, mitochondrial", "gene_name": "Exog", "organism": "Mouse", "refseq_name": "nuclease EXOG, mitochondrial isoform 1 precursor", "refseq_ac": "NP_766044", "gene_names_uniprotkb": "Exog; Endogl1", "gene_names_refseq": "ENGL-B; ENGL-a; Endogl1; Endogl2; Engla; Englb; Engl; Exog", "protein_names_uniprotkb": "Nuclease EXOG, mitochondrial; 3.1.30.-; Endo G-like 1; Endonuclease G-like 1", "protein_names_refseq": "endo G-like 1; endo/exonuclease (5'-3'), endonuclease G-like; endonuclease G-like 1; nuclease EXOG, mitochondrial isoform 1 precursor; nuclease EXOG, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:208194)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;33300544;37507081", "class_list": "", "function": "Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFL2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004521 RNA endonuclease activity;GO:0000014 single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZD7-1", "uniprot_id": "GAR1B_MOUSE", "mass": 38687.0, "length": 341, "protein_name": "Golgi-associated RAB2 interactor protein 1B", "gene_name": "Garin1b", "organism": "Mouse", "refseq_name": "Golgi-associated RAB2 interactor protein 1B isoform 1", "refseq_ac": "NP_001276592", "gene_names_uniprotkb": "Garin1b; Fam137a; Fam71f1; Garil1", "gene_names_refseq": "Fam71f1; GARI-L1; Garin1b; Gm764; NYD-SP18", "protein_names_uniprotkb": "Golgi-associated RAB2 interactor protein 1B; GARI-L1; Golgi-associated RAB2 interactor-like 1", "protein_names_refseq": "Golgi associated RAB2 interactor protein 1B; Golgi associated RAB2 interactor-like 1; Golgi-associated RAB2 interactor protein 1B isoform 1; Golgi-associated Rab2B interactor-like 1; family with sequence similarity 71, member F1; protein FAM71F1; testes development-related NYD-SP18", "tax_id": 10090, "disease": "", "pathway": " (mmu:330277)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34714330", "class_list": "", "function": "FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice., [RefSeq, PubMed]; RAB2B effector protein required for accurate acrosome formation and normal male fertility (PubMed:34714330). In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation (PubMed:34714330)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW23", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007340 acrosome reaction;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UZD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ND56-1", "uniprot_id": "TLC3A_MOUSE", "mass": 29467.0, "length": 257, "protein_name": "TLC domain-containing protein 3A", "gene_name": "Tlcd3a", "organism": "Mouse", "refseq_name": "TLC domain-containing protein 3A isoform a", "refseq_ac": "NP_082049", "gene_names_uniprotkb": "Tlcd3a; Fam57a", "gene_names_refseq": "2310047D13Rik; 4932415L08Rik; 5430402E13Rik; 5430420K21Rik; Fam57a; Tlcd3a; Wdt3", "protein_names_uniprotkb": "TLC domain-containing protein 3A; Protein FAM57A", "protein_names_refseq": "TLC domain-containing protein 3A isoform a; TLC domain-containing protein 3A; family with sequence similarity 57, member A; protein FAM57A; whn-dependent transcript 3", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:116972)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ND56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQS4-1", "uniprot_id": "EEIG2_MOUSE", "mass": 36514.0, "length": 339, "protein_name": "EEIG family member 2", "gene_name": "Eeig2", "organism": "Mouse", "refseq_name": "EEIG family member 2", "refseq_ac": "NP_001157039", "gene_names_uniprotkb": "Eeig2; Fam102b", "gene_names_refseq": "1600010D10Rik; B430201A12Rik; Eeig2; Fam102b", "protein_names_uniprotkb": "EEIG family member 2; EEIG2", "protein_names_refseq": "EEIG family member 2; family with sequence similarity 102, member B; protein FAM102B", "tax_id": 10090, "disease": "", "pathway": " (mmu:329739)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23478294;31219806", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BQS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YC5-1", "uniprot_id": "FA12_MOUSE", "mass": 65701.0, "length": 597, "protein_name": "Coagulation factor XII", "gene_name": "F12", "organism": "Mouse", "refseq_name": "coagulation factor XII preproprotein", "refseq_ac": "NP_067464", "gene_names_uniprotkb": "F12", "gene_names_refseq": "F12; FXII; HAF", "protein_names_uniprotkb": "Coagulation factor XII; 3.4.21.38; HAF; Hageman factor", "protein_names_refseq": "coagulation factor XII preproprotein; factor XII; hageman factor", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); hereditary angioedema type III (Disease Ontology:DOID:0080940); acquired angioedema (Disease Ontology:DOID:0080941); hereditary angioedema (Disease Ontology:DOID:14735); angioedema (Disease Ontology:DOID:1558); factor XII deficiency (Disease Ontology:DOID:2231); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:58992); (R-MMU-9855719); (R-MMU-9935598); (R-MMU-9970672)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15351846;21750661;34428180;36706361;39261453", "class_list": "", "function": "F12 KNOCKOUT MICE, generated to elucidate the biological role(s) of FXII, had a markedly prolonged APTT. Deficiency of murine FXII does not cause thrombophilia or impaired fibrinolysis or affect hemostasis., [RefSeq, PubMed]; Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease., [RefSeq, PubMed]; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity)., [UniProtKB, UniProtKB]; Factor XII signaling via uPAR-integrin beta1 axis promotes tubular senescence in diabetic kidney disease. Erratum:[Nat Commun. 2026 Jan 14;17(1):540. doi: 10.1038/s41467-026-68442-z. PMID: 41535290] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 11, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O35727;Q6PER0", "ec_number_list": "3.4.21.34;3.4.21.38;3.4.21.27", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0007596 blood coagulation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80YC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97435-1", "uniprot_id": "ENTK_MOUSE", "mass": 118735.0, "length": 1069, "protein_name": "Enteropeptidase", "gene_name": "Tmprss15", "organism": "Mouse", "refseq_name": "enteropeptidase isoform 1 precursor", "refseq_ac": "NP_032967", "gene_names_uniprotkb": "Tmprss15; Entk; Prss7", "gene_names_refseq": "Entk; Prss7; Tmprss15", "protein_names_uniprotkb": "Enteropeptidase; 3.4.21.9; Enterokinase; Serine protease 7; Transmembrane protease serine 15", "protein_names_refseq": "enteropeptidase isoform 1 precursor; enteropeptidase; protease, serine, 7 (enterokinase)", "tax_id": 10090, "disease": "enterokinase deficiency (Disease Ontology:DOID:0111667)", "pathway": " (mmu:19146)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1799406;21750661;23954298;31599954;9486188", "class_list": "", "function": "Enteropeptidase could inhibit osteoclastogenesis in vitro through the cleavage of RANK., [RefSeq, PubMed]; Peptide sequencing of amino terminus of light chain of cow enterokinase, identifying the cleavage site, [RefSeq, PubMed]; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 17, "predicted_n_glycosites": 16, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q148Y3", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23683-1", "uniprot_id": "EVX1_MOUSE", "mass": 43198.0, "length": 416, "protein_name": "Homeobox even-skipped homolog protein 1", "gene_name": "Evx1", "organism": "Mouse", "refseq_name": "homeobox even-skipped homolog protein 1", "refseq_ac": "NP_031992", "gene_names_uniprotkb": "Evx1", "gene_names_refseq": "Evx-1; Evx1", "protein_names_uniprotkb": "Homeobox even-skipped homolog protein 1; EVX-1", "protein_names_refseq": "even skipped homeotic gene 1 homolog; homeobox even-skipped homolog protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14028)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1349539;1971786;21750661;35820727", "class_list": "", "function": "May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030424 axon;GO:0044297 cell body", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0097377 spinal cord interneuron axon guidance;GO:1904936 interneuron migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQN5-1", "uniprot_id": "FA78B_MOUSE", "mass": 29835.0, "length": 261, "protein_name": "Protein FAM78B", "gene_name": "Fam78b", "organism": "Mouse", "refseq_name": "protein FAM78B", "refseq_ac": "NP_001153733", "gene_names_uniprotkb": "Fam78b", "gene_names_refseq": "C030014K22Rik; C030020L09Rik; Fam78b", "protein_names_uniprotkb": "Protein FAM78B", "protein_names_refseq": "protein FAM78B", "tax_id": 10090, "disease": "", "pathway": " (mmu:226610)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSM0;Q8CC61", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BQN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56960-1", "uniprot_id": "EXOSX_MOUSE", "mass": 100942.0, "length": 887, "protein_name": "Exosome complex component 10", "gene_name": "Exosc10", "organism": "Mouse", "refseq_name": "exosome complex component 10 isoform 1", "refseq_ac": "NP_057908", "gene_names_uniprotkb": "Exosc10; Pmscl2", "gene_names_refseq": "Exosc10; PM-Scl; PM/Scl-100; Pmscl2; RRP6; p2; p3; p4", "protein_names_uniprotkb": "Exosome complex component 10; 3.1.13.-; Autoantigen PM/Scl 2 homolog; Polymyositis/scleroderma autoantigen 2 homolog", "protein_names_refseq": "P100 polymyositis-scleroderma overlap syndrome associated autoantigen homolog; autoantigen PM/Scl 2 homolog; exosome complex component 10 isoform 1; exosome complex component 10; polymyositis/scleroderma autoantigen 2 homolog", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:50912); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10708524;21750661;26857222;29118343;31219806;32313933;34965385;36923944", "class_list": "", "function": "Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA (By similarity). Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (By similarity). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (By similarity). Plays a role in oocyte development, maturation and survival (PubMed:32313933, PubMed:36923944). Required for normal testis development and mitotic division of spermatogonia (PubMed:29118343). Plays a role in proper embryo development (PubMed:32313933, PubMed:34965385, PubMed:36923944). Required for global protein translation (By similarity). Required for cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ARY9;Q9QYS8;Q9R0B1", "ec_number_list": "3.1.-.-;3.6.4.13;2.1.1.-;3.1.13.-;2.7.1.78;2.7.7.19;3.1.13.1;3.1.26.-;3.4.22.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003727 single-stranded RNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004532 RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006281 DNA repair;GO:0006396 RNA processing;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56960-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFV2-1", "uniprot_id": "F149A_MOUSE", "mass": 85100.0, "length": 787, "protein_name": "Protein FAM149A", "gene_name": "Fam149a", "organism": "Mouse", "refseq_name": "protein FAM149A", "refseq_ac": "NP_705763", "gene_names_uniprotkb": "Fam149a", "gene_names_refseq": "Fam149a; mKIAA4166", "protein_names_uniprotkb": "Protein FAM149A", "protein_names_refseq": "protein FAM149A", "tax_id": 10090, "disease": "", "pathway": " (mmu:212326)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CFV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHI7-1", "uniprot_id": "EXOS9_MOUSE", "mass": 48937.0, "length": 438, "protein_name": "Exosome complex component RRP45", "gene_name": "Exosc9", "organism": "Mouse", "refseq_name": "exosome complex component RRP45", "refseq_ac": "NP_062266", "gene_names_uniprotkb": "Exosc9; Pmscl1", "gene_names_refseq": "Exosc9; PM/Scl-75; Pmscl1; RRP45; p5; p6", "protein_names_uniprotkb": "Exosome complex component RRP45; Autoantigen PM/Scl 1; Exosome component 9; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-75; Polymyositis/scleroderma autoantigen 1; Polymyositis/scleroderma autoantigen 75 kDa", "protein_names_refseq": "P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; autoantigen PM/Scl 1; exosome complex component RRP45; exosome complex exonuclease RRP45; polymyositis/scleroderma autoantigen 1; polymyositis/scleroderma autoantigen 75 kDa", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 1D (Disease Ontology:DOID:0112323)", "pathway": " (mmu:50911); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "10708524;20173027;21183079;21750661;34428180;35820727", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSZ2", "ec_number_list": "", "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006396 RNA processing;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPB5-1", "uniprot_id": "FBLN3_MOUSE", "mass": 54953.0, "length": 493, "protein_name": "EGF-containing fibulin-like extracellular matrix protein 1", "gene_name": "Efemp1", "organism": "Mouse", "refseq_name": "EGF-containing fibulin-like extracellular matrix protein 1 precursor", "refseq_ac": "NP_666127", "gene_names_uniprotkb": "Efemp1; Fbln3", "gene_names_refseq": "Efemp1", "protein_names_uniprotkb": "EGF-containing fibulin-like extracellular matrix protein 1; FIBL-3; Fibulin-3", "protein_names_refseq": "EGF-containing fibulin-like extracellular matrix protein 1 precursor; EGF-containing fibulin-like extracellular matrix protein 1; FIBL-3; fibulin-3", "tax_id": 10090, "disease": "Doyne honeycomb retinal dystrophy (Disease Ontology:DOID:0060745); high grade glioma (Disease Ontology:DOID:3070); cutis laxa (Disease Ontology:DOID:3144); macular degeneration (Disease Ontology:DOID:4448); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:216616)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12915309;17664227;17872905;21750661;26162006;28135057;31219806;37062520;37696945;37828378;38083999", "class_list": "", "function": "Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity)., [UniProtKB, UniProtKB]; Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Novel mutation in EFEMP1 identified from two Chinese POAG families differentially activated endoplasmic reticulum stress markers and induced glaucoma in mouse., [RefSeq, PubMed]; PUM2 regulates the formation of thoracic aortic dissection through EFEMP1., [RefSeq, PubMed]; The Efemp1 knock-in mice reconstitute the most important histopathologic symptoms of both Malattia leventinese and age-related macular degeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6Y3N6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0005006 epidermal growth factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:1903975 regulation of glial cell migration;GO:0008284 positive regulation of cell population proliferation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0006355 regulation of DNA-templated transcription;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BPB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64176-1", "uniprot_id": "EST1E_MOUSE", "mass": 61582.0, "length": 562, "protein_name": "Carboxylesterase 1E", "gene_name": "Ces1e", "organism": "Mouse", "refseq_name": "carboxylesterase 1E isoform 1 precursor", "refseq_ac": "NP_598421", "gene_names_uniprotkb": "Ces1e; Es22", "gene_names_refseq": "Ces1e; Eg; Es-22; Es22; egasyn", "protein_names_uniprotkb": "Carboxylesterase 1E; 3.1.1.1; Egasyn; Es-22; Esterase-22; Liver carboxylesterase 22", "protein_names_refseq": "carboxylesterase 1E isoform 1 precursor; esterase-22; liver carboxylesterase 22", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stomach cancer (Disease Ontology:DOID:10534); gastrointestinal system cancer (Disease Ontology:DOID:3119); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13897)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;1783403;19723663;21750661;25801056;30084848;34428180;37267638", "class_list": "", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters., [UniProtKB, UniProtKB]; Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development., [RefSeq, PubMed]; The Es22 plays a role in liver retinoid metabolism., [RefSeq, PubMed]; The carboxylesterase 1d (Ces1d) and carboxylesterase 1e (Ces1e) expression and the capacity of hydrolytic activity of liver and intestine decreased, whereas the Akt/mTOR/HIF-1alpha/ Stra13 (DEC1) signaling was activated in type 2 diabetes mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.1;3.1.1.-;3.1.1.23;3.1.1.79;3.1.1.3;3.1.1.88;3.1.1.13;3.1.1.67;3.1.1.28", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0106435 carboxylesterase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0001523 retinoid metabolic process;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08644-1", "uniprot_id": "EPHB6_MOUSE", "mass": 110107.0, "length": 1014, "protein_name": "Ephrin type-B receptor 6", "gene_name": "Ephb6", "organism": "Mouse", "refseq_name": "ephrin type-B receptor 6 precursor", "refseq_ac": "NP_001139823", "gene_names_uniprotkb": "Ephb6; Cekl", "gene_names_refseq": "Cekl; Ephb6; Mep", "protein_names_uniprotkb": "Ephrin type-B receptor 6; MEP; Tyrosine-protein kinase-defective receptor EPH-6", "protein_names_refseq": "chicken eph/elk receptor-like protein; ephrin type A receptor; ephrin type-B receptor 6 precursor; ephrin type-B receptor 6; tyrosine-protein kinase-defective receptor EPH-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:13848); (R-MMU-2682334); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "21750661;25428506;34428180;8761299", "class_list": "", "function": "Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Can recruit SH2 domain-containing signaling adapters following phosphorylation by EPHB4., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ77;Q8BN76;Q8K0A9", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0016020 membrane", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0050798 activated T cell proliferation;GO:0007411 axon guidance;GO:0001806 type IV hypersensitivity;GO:0002456 T cell mediated immunity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08644-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88783-1", "uniprot_id": "FA5_MOUSE", "mass": 247230.0, "length": 2183, "protein_name": "Coagulation factor V", "gene_name": "F5", "organism": "Mouse", "refseq_name": "coagulation factor V preproprotein", "refseq_ac": "NP_032002", "gene_names_uniprotkb": "F5", "gene_names_refseq": "Cf-5; Cf5; F5", "protein_names_uniprotkb": "Coagulation factor V; Activated protein C cofactor", "protein_names_refseq": "activated protein C cofactor; coagulation factor V preproprotein", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); thrombosis (Disease Ontology:DOID:0060903); thrombophilia due to activated protein C resistance (Disease Ontology:DOID:0111902); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); portal hypertension (Disease Ontology:DOID:10762); Budd-Chiari syndrome (Disease Ontology:DOID:11512); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); factor V deficiency (Disease Ontology:DOID:2216); hepatitis (Disease Ontology:DOID:2237); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); cerebral infarction (Disease Ontology:DOID:3526); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); pulmonary embolism (Disease Ontology:DOID:9477); hypereosinophilic syndrome (Disease Ontology:DOID:999)", "pathway": " (mmu:14067); (R-MMU-114608); (R-MMU-204005); (R-MMU-381426); (R-MMU-5694530); (R-MMU-8957275); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16944957;21183079;26495903;29187734;31048328;34428180;39627609;9616155", "class_list": "", "function": "Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin., [UniProtKB]; Selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in the peritoneal cavity., [RefSeq, PubMed]; This gene encodes a glycoprotein coagulation factor that plays a critical role in the process of blood coagulation and hemostasis. The encoded protein is activated by thrombin, to generate a heterodimer containing heavy and light chains held together by calcium ions. About half of the mice lacking the encoded protein die at an embryonic stage possible due to abnormal yolk-sac vasculature while the remaining animals succumbed to massive hemorrhage immediately after birth. A point mutation in this gene has been shown to cause disseminated intravascular thrombosis in the perinatal period, resulting in frequent deaths of newborn mice. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 21, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTQ2;Q3UV80", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0008015 blood circulation;GO:0031638 zymogen activation;GO:0032571 response to vitamin K", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O88783-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41163-1", "uniprot_id": "ETV2_MOUSE", "mass": 37083.0, "length": 335, "protein_name": "ETS translocation variant 2", "gene_name": "Etv2", "organism": "Mouse", "refseq_name": "ETS translocation variant 2", "refseq_ac": "NP_031985", "gene_names_uniprotkb": "Etv2; Er71; Etsrp71", "gene_names_refseq": "Etsrp71; Etv2", "protein_names_uniprotkb": "ETS translocation variant 2; Ets-related protein 71", "protein_names_refseq": "ETS translocation variant 2; ets variant gene 2; ets-related protein 71", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852)", "pathway": " (mmu:14008)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1340465;15780752;16619273;36512477;38430850", "class_list": "", "function": "Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'., [UniProtKB]; ETV2 Upregulation Marks the Specification of Early Cardiomyocytes and Endothelial Cells During Co-differentiation., [RefSeq, PubMed]; Etsrp71 gene was cloned and its promoter was characterized., [RefSeq, PubMed]; Overexpression of ETV2 in BMSCs promoted wound healing in cutaneous wound mice by triggering the differentiation of BMSCs into endothelial cells and modulating the transformation of M1 phenotype macrophages to M2 phenotype macrophages., [RefSeq, PubMed]; TSGA impairs the ability of ER71 to activate transcription, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ08", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54731-1", "uniprot_id": "FAF1_MOUSE", "mass": 73863.0, "length": 649, "protein_name": "FAS-associated factor 1", "gene_name": "Faf1", "organism": "Mouse", "refseq_name": "FAS-associated factor 1 isoform 1", "refseq_ac": "NP_032009", "gene_names_uniprotkb": "Faf1", "gene_names_refseq": "Dffrx; Faf1; Fam", "protein_names_uniprotkb": "FAS-associated factor 1", "protein_names_refseq": "FAS-associated factor 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14084)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;25428506;28135057;30200976;37828378;8524870", "class_list": "", "function": "FAF1 plays a key role in ischemic retinal damage and may be implicated in the pathogenesis of retinal ischemic disease Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-binding protein (By similarity). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (By similarity). Potentiates but cannot initiate FAS-induced apoptosis (PubMed:8524870)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1F8", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0006915 apoptotic process;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0045732 positive regulation of protein catabolic process;GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P54731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60840-1", "uniprot_id": "ENSA_MOUSE", "mass": 13335.0, "length": 121, "protein_name": "Alpha-endosulfine", "gene_name": "Ensa", "organism": "Mouse", "refseq_name": "alpha-endosulfine isoform b", "refseq_ac": "NP_001021383", "gene_names_uniprotkb": "Ensa", "gene_names_refseq": "1700020C18Rik; 2610007F17Rik; Ensa", "protein_names_uniprotkb": "Alpha-endosulfine; ARPP-19e", "protein_names_refseq": "ARPP-19e; alpha-endosulfine isoform b; alpha-endosulfine", "tax_id": 10090, "disease": "", "pathway": " (mmu:56205)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11279279;30626720;9653196", "class_list": "", "function": "During mouse embryogenesis, the Arpp19 and Ensa paralog genes display specific functions by differentially controlling cell cycle progression., [RefSeq, PubMed]; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5D069;Q6PBG4;Q9CQZ9;Q9Z0G1", "ec_number_list": "", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0005102 signaling receptor binding;GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding;GO:0019212 phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70186-1", "uniprot_id": "EPYC_MOUSE", "mass": 36763.0, "length": 322, "protein_name": "Epiphycan", "gene_name": "Epyc", "organism": "Mouse", "refseq_name": "epiphycan precursor", "refseq_ac": "NP_031910", "gene_names_uniprotkb": "Epyc; Dspg3; Pglb", "gene_names_refseq": "Dspg3; Epyc; PG-Lb; SLRR3B", "protein_names_uniprotkb": "Epiphycan; Dermatan sulfate proteoglycan 3; PG-Lb; Proteoglycan-Lb; Small chondroitin/dermatan sulfate proteoglycan", "protein_names_refseq": "dermatan sulfate proteoglycan 3; dermatan sulphate proteoglycan 3; epiphycan precursor; proteoglycan-Lb; small chondroitin/dermatan sulfate proteoglycan", "tax_id": 10090, "disease": "", "pathway": " (mmu:13516)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10633869;8836137;9560328", "class_list": "glycogene", "function": "May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70375-1", "uniprot_id": "FA7_MOUSE", "mass": 50276.0, "length": 446, "protein_name": "Coagulation factor VII", "gene_name": "F7", "organism": "Mouse", "refseq_name": "coagulation factor VII preproprotein", "refseq_ac": "NP_034302", "gene_names_uniprotkb": "F7; Cf7", "gene_names_refseq": "Cf7; F7; FVII", "protein_names_uniprotkb": "Coagulation factor VII; 3.4.21.21; Serum prothrombin conversion accelerator", "protein_names_refseq": "coagulation factor VII preproprotein; serum prothrombin conversion accelerator", "tax_id": 10090, "disease": "acquired angioedema (Disease Ontology:DOID:0080941); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); hypothyroidism (Disease Ontology:DOID:1459); hereditary angioedema (Disease Ontology:DOID:14735); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); factor VII deficiency (Disease Ontology:DOID:2215); prothrombin deficiency (Disease Ontology:DOID:2235); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14068); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "18316400;25428506;31219806;8701412;8972017", "class_list": "", "function": "Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (By similarity)., [UniProtKB]; This gene encodes a vitamin K-dependent serine protease that plays a critical role in the extrinsic pathway of blood coagulation. Upon contact with tissue factor III (TF III), the encoded protein forms an activated complex termed TF-FVIIa that initiates the coagulation cascade involving other coagulation factors, ultimately resulting in a fibrin clot. Complete lack of the encoded protein in mice results in in perinatal lethality due to bleeding from normal blood vessels. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61109", "ec_number_list": "2.3.1.48;3.4.21.6;3.4.21.22;3.4.21.75;3.4.21.21;4.1.1.90", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0031982 vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0097068 response to thyroxine;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0001666 response to hypoxia;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05816-1", "uniprot_id": "FABP5_MOUSE", "mass": 15137.0, "length": 135, "protein_name": "Fatty acid-binding protein 5", "gene_name": "Fabp5", "organism": "Mouse", "refseq_name": "fatty acid-binding protein 5 isoform 1", "refseq_ac": "NP_034764", "gene_names_uniprotkb": "Fabp5; Fabpe; Klbp; Mal1", "gene_names_refseq": "E-FABP; Fabp5; Fabpe; Klbp; PA-FABP; mal1", "protein_names_uniprotkb": "Fatty acid-binding protein 5; E-FABP; Epidermal-type fatty acid-binding protein; Fatty acid-binding protein, epidermal; Keratinocyte lipid-binding protein; PA-FABP; Psoriasis-associated fatty acid-binding protein homolog", "protein_names_refseq": "epidermal-type fatty acid-binding protein; epithelial fatty acid-binding protein; fatty acid-binding protein 5 isoform 1; fatty acid-binding protein, epidermal; keratinocyte lipid-binding protein; psoriasis-associated fatty acid-binding protein homolog", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:16592); (R-MMU-163560); (R-MMU-5362517); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12540600;17512406;17579051;24531463;28135057;29440395;29531087;37507081;8349619;8608126;9666100;9795232", "class_list": "", "function": "Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind (PubMed:12540600, PubMed:8608126). In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival (PubMed:17512406). May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling (PubMed:29531087). Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (PubMed:29440395). May be involved in keratinocyte differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Metabolic-inflammatory pathway cross-regulation by epidermal-type FABP contributes to adaptive immune responses and subsequent autoimmune inflammation., [RefSeq, PubMed]; The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15;6.2.1.7;6.2.1.24", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0042802 identical protein binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:1990379 lipid transport across blood-brain barrier;GO:0031392 regulation of prostaglandin biosynthetic process;GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q05816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07968-1", "uniprot_id": "F13B_MOUSE", "mass": 76195.0, "length": 669, "protein_name": "Coagulation factor XIII B chain", "gene_name": "F13b", "organism": "Mouse", "refseq_name": "coagulation factor XIII B chain precursor", "refseq_ac": "NP_112441", "gene_names_uniprotkb": "F13b; Cf13b", "gene_names_refseq": "Cf-13b; Cf13b; F13b", "protein_names_uniprotkb": "Coagulation factor XIII B chain; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain", "protein_names_refseq": "coagulation factor XIII B chain precursor; coagulation factor XIII B chain; protein-glutamine gamma-glutamyltransferase B chain; transglutaminase B chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:14060); (R-MMU-9769733)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17330941;22045386;27561317;32678423;34428180;37883802;8468048", "class_list": "", "function": "Physiological significance of mouse TG2 and Factor XIII through identification of substrate proteins in MC3T3-E1 cells., [RefSeq, PubMed]; Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration., [RefSeq, PubMed]; Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency., [RefSeq, PubMed]; The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin., [UniProtKB, UniProtKB]; These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations., [RefSeq, PubMed]; This gene encodes subunit B of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit A to form a heterotetrameric protein that circulates in the plasma. During the blood coagulation process, thrombin-mediated proteolytic cleavage of the subunit A results in the dissociation of the encoded protein from the heterotetramer. Male mice lacking the encoded protein exhibit mild fibrosis together with hemosiderin deposits in the heart. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1AY02", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007596 blood coagulation;GO:0072378 blood coagulation, fibrin clot formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q07968-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08879-1", "uniprot_id": "FBLN1_MOUSE", "mass": 78033.0, "length": 705, "protein_name": "Fibulin-1", "gene_name": "Fbln1", "organism": "Mouse", "refseq_name": "fibulin-1 isoform 2 precursor", "refseq_ac": "NP_001334017", "gene_names_uniprotkb": "Fbln1", "gene_names_refseq": "Fbln1", "protein_names_uniprotkb": "Fibulin-1; BM-90; Basement-membrane protein 90; FIBL-1", "protein_names_refseq": "BM-90/fibulin extracellular matrix glyroprotein; BM-90; FIBL-1; basement-membrane protein 90; fibulin-1 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14114)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10022829;10400671;11238726;11589703;11737251;11829738;11836357;17699513;2249686;38184021;39201719;7844816;8354280;8850569;9299350", "class_list": "", "function": "A Bioinformatics-Based Study on Methylation Alterations of the FBLN1 Gene in Hippocampal Tissue of Alzheimer's Disease Model DKO and DTG Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Fibulin 1, targeted by microRNA-24-3p, promotes cell proliferation and migration in vascular smooth muscle cells, contributing to the development of atherosclerosis in APOE[-/-] mice., [RefSeq, PubMed]; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q08878;Q8C3B1;Q91ZC9;Q922K8", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0016504 peptidase activator activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0071953 elastic fiber", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:2000647 negative regulation of stem cell proliferation;GO:0007162 negative regulation of cell adhesion;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q08879-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VAV2-1", "uniprot_id": "EXPH5_MOUSE", "mass": 217643.0, "length": 1960, "protein_name": "Exophilin-5", "gene_name": "Exph5", "organism": "Mouse", "refseq_name": "exophilin-5", "refseq_ac": "NP_789816", "gene_names_uniprotkb": "Exph5; Kiaa0624; Slac2b", "gene_names_refseq": "AC079869.22gm5; B130009M24Rik; E030050P12; Exph5; Kiaa0624; Slac2b; slac2-b", "protein_names_uniprotkb": "Exophilin-5; SlaC2-b; Slp homolog lacking C2 domains b; Synaptotagmin-like protein homolog lacking C2 domains b", "protein_names_refseq": "exophilin-5; slp homolog lacking C2 domains b; synaptotagmin-like homologue lacking C2 domains b; synaptotagmin-like protein homolog lacking C2 domains b", "tax_id": 10090, "disease": "epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (mmu:320051)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11773082;12590134;32240120;34428180", "class_list": "", "function": "Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses., [RefSeq, PubMed]; May act as Rab effector protein and play a role in vesicle trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNV5;Q6A034;Q812E3", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005768 endosome", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0006886 intracellular protein transport;GO:0050714 positive regulation of protein secretion;GO:0003334 keratinocyte development;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q0VAV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VBM2-1", "uniprot_id": "FA83B_MOUSE", "mass": 114676.0, "length": 1012, "protein_name": "Protein FAM83B", "gene_name": "Fam83b", "organism": "Mouse", "refseq_name": "protein FAM83B", "refseq_ac": "NP_001038983", "gene_names_uniprotkb": "Fam83b", "gene_names_refseq": "C530008M07Rik; Fam83b; Gm516; Sack1b", "protein_names_uniprotkb": "Protein FAM83B", "protein_names_refseq": "family with sequence similarity 83, member B; protein FAM83B", "tax_id": 10090, "disease": "", "pathway": " (mmu:208994); (R-MMU-177929); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;25428506;30084848;34428180", "class_list": "", "function": "Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWY1", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005154 epidermal growth factor receptor binding;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding;GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q0VBM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14BJ1-1", "uniprot_id": "FA89A_MOUSE", "mass": 18690.0, "length": 175, "protein_name": "Protein FAM89A", "gene_name": "Fam89a", "organism": "Mouse", "refseq_name": "protein FAM89A", "refseq_ac": "NP_001074589", "gene_names_uniprotkb": "Fam89a", "gene_names_refseq": "2310031A18Rik; Fam89a", "protein_names_uniprotkb": "Protein FAM89A", "protein_names_refseq": "protein FAM89A", "tax_id": 10090, "disease": "", "pathway": " (mmu:69627)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3X3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q14BJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14DQ1-1", "uniprot_id": "F219B_MOUSE", "mass": 21006.0, "length": 197, "protein_name": "Protein FAM219B", "gene_name": "Fam219b", "organism": "Mouse", "refseq_name": "protein FAM219B isoform 1", "refseq_ac": "NP_001159836", "gene_names_uniprotkb": "Fam219b", "gene_names_refseq": "2310046O06Rik; Fam219b", "protein_names_uniprotkb": "Protein FAM219B", "protein_names_refseq": "protein FAM219B isoform 1; protein FAM219B; uncharacterized protein C15orf17 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78323)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSZ6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q14DQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TC72-1", "uniprot_id": "FAH2A_MOUSE", "mass": 34676.0, "length": 313, "protein_name": "Oxaloacetate tautomerase Fahd2a, mitochondrial", "gene_name": "Fahd2a", "organism": "Mouse", "refseq_name": "oxaloacetate tautomerase Fahd2a, mitochondrial", "refseq_ac": "NP_083905", "gene_names_uniprotkb": "Fahd2a", "gene_names_refseq": "1500003K14Rik; B430104H02Rik; Cgi-105; Fahd2a; Fahd2", "protein_names_uniprotkb": "Oxaloacetate tautomerase Fahd2a, mitochondrial; 5.3.2.2; Fumarylacetoacetate hydrolase domain-containing protein 2A", "protein_names_refseq": "fumarylacetoacetate hydrolase domain-containing protein 2A; oxaloacetate tautomerase Fahd2a, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68126)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15774318;21183079;23576753;23806337", "class_list": "", "function": "CGI-105 mRNA is induced in differentiating 3T3-L1 cells by adrenocorticotropic hormones., [RefSeq, PubMed]; Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J094;Q8K0V8", "ec_number_list": "5.3.2.2;3.7.1.5;4.1.1.112", "go_molecular_function": "GO:0046872 metal ion binding;GO:0050163 oxaloacetate tautomerase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TC72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TDN2-1", "uniprot_id": "FAF2_MOUSE", "mass": 52471.0, "length": 445, "protein_name": "FAS-associated factor 2", "gene_name": "Faf2", "organism": "Mouse", "refseq_name": "FAS-associated factor 2", "refseq_ac": "NP_848484", "gene_names_uniprotkb": "Faf2; Kiaa0887; Ubxd8", "gene_names_refseq": "2210404D11Rik; Faf2; Ubxd8; mKIAA0887", "protein_names_uniprotkb": "FAS-associated factor 2; UBX domain-containing protein 8", "protein_names_refseq": "FAS-associated factor 2; UBX domain containing 8; UBX domain-containing protein 8; protein expressed in T-cells and eosinophils in atopic dermatitis", "tax_id": 10090, "disease": "", "pathway": " (mmu:76577); (R-MMU-6798695); (R-MMU-8980692)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24160817;25970332;31219806;31599954;34428180", "class_list": "", "function": "Depletion of UBXD8 in hepatocytes suppresses VLDL secretion, and could lead to periportal steatosis when mice are fed a high-fat diet. Erratum:[PLoS One. 2016 Jan 25;11(1):e0148004. doi: 10.1371/journal.pone.0148004. PMID: 26808825] Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Recruits ATPase VCP to lipid droplets and also binds to phospholipase PNPLA2/ATGL, inhibiting PNPLA2 activity by promoting its dissociation from its ABHD5/CGI-58 activator. This inhibits PNPLA2-mediated triacylglycerol hydrolysis and leads to inhibition of lipid droplet degradation. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9W2;Q80TP7;Q80W42", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding;GO:0055102 lipase inhibitor activity;GO:0035473 lipase binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0034389 lipid droplet organization;GO:0006986 response to unfolded protein;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3TDN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TVP5-1", "uniprot_id": "OTULL_MOUSE", "mass": 41576.0, "length": 353, "protein_name": "Inactive ubiquitin thioesterase OTULINL", "gene_name": "Otulinl", "organism": "Mouse", "refseq_name": "inactive ubiquitin thioesterase OTULINL isoform 1", "refseq_ac": "NP_001229352", "gene_names_uniprotkb": "Otulinl; Fam105a", "gene_names_refseq": "9830126M18; Fam105a; Otulinl", "protein_names_uniprotkb": "Inactive ubiquitin thioesterase OTULINL", "protein_names_refseq": "family with sequence similarity 105, member A; inactive ubiquitin thioesterase FAM105A; inactive ubiquitin thioesterase OTULINL isoform 1; inactive ubiquitin thioesterase OTULINL; protein FAM105A", "tax_id": 10090, "disease": "", "pathway": " (mmu:223433)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Lacks deubiquitinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8Q4;Q80WP7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:1990108 protein linear deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TVP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UEN2-1", "uniprot_id": "SHLD2_MOUSE", "mass": 99090.0, "length": 891, "protein_name": "Shieldin complex subunit 2", "gene_name": "Shld2", "organism": "Mouse", "refseq_name": "shieldin complex subunit 2", "refseq_ac": "NP_083665", "gene_names_uniprotkb": "Shld2; Fam35a; Rinn2", "gene_names_refseq": "3110001K24Rik; Fam35a; Shld2", "protein_names_uniprotkb": "Shieldin complex subunit 2; Protein FAM35A; RINN1-REV7-interacting novel NHEJ regulator 2", "protein_names_refseq": "RINN1-REV7-interacting novel NHEJ regulator 2; family with sequence similarity 35, member A; protein FAM35A; shieldin complex subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75698)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34418053;34428180;35820727", "class_list": "", "function": "Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q8K3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0043247 telomere maintenance in response to DNA damage;GO:0006281 DNA repair;GO:0045830 positive regulation of isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UEN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3US41-1", "uniprot_id": "ESRP1_MOUSE", "mass": 75549.0, "length": 680, "protein_name": "Epithelial splicing regulatory protein 1", "gene_name": "Esrp1", "organism": "Mouse", "refseq_name": "epithelial splicing regulatory protein 1 isoform 2", "refseq_ac": "NP_001277312", "gene_names_uniprotkb": "Esrp1; Rbm35a", "gene_names_refseq": "2210008M09Rik; A630065D16; Esrp1; Rbm35a", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 1; RNA-binding motif protein 35A; RNA-binding protein 35A", "protein_names_refseq": "RNA binding motif protein 35A; epithelial splicing regulatory protein 1 isoform 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 109 (Disease Ontology:DOID:0111639)", "pathway": " (mmu:207920)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19285943;21750661;29107558;34428180;37090731", "class_list": "", "function": "Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma through altering FGFR2 splicing and macrophage polarization. Publication Status: Online-Only, [RefSeq, PubMed]; Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 splicing., [RefSeq, PubMed]; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (PubMed:29107558)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AJQ4;A2AJQ5;A2AJQ6;A2AJQ7;A2AJQ8;Q3TLQ3;Q6PCL4;Q8C9F5;Q8K0G2", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0050679 positive regulation of epithelial cell proliferation;GO:0042669 regulation of inner ear auditory receptor cell fate specification;GO:0060445 branching involved in salivary gland morphogenesis;GO:0060441 epithelial tube branching involved in lung morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3US41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZH1-1", "uniprot_id": "EREP1_MOUSE", "mass": 49804.0, "length": 451, "protein_name": "Endosomal transmembrane epsin interactor 1", "gene_name": "Entrep1", "organism": "Mouse", "refseq_name": "endosomal transmembrane epsin interactor 1", "refseq_ac": "NP_001107646", "gene_names_uniprotkb": "Entrep1; Fam189a2; Gm967", "gene_names_refseq": "Entrep1; Fam189a2; Gm967", "protein_names_uniprotkb": "Endosomal transmembrane epsin interactor 1", "protein_names_refseq": "endosomal transmembrane epsin interactor 1; family with sequence similarity 189, member A2; protein FAM189A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:381217)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QP68", "ec_number_list": "", "go_molecular_function": "GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0031623 receptor internalization;GO:0038160 CXCL12-activated CXCR4 signaling pathway;GO:0022401 negative adaptation of signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XFR0-1", "uniprot_id": "EPAB2_MOUSE", "mass": 30263.0, "length": 273, "protein_name": "Embryonic polyadenylate-binding protein 2", "gene_name": "Pabpn1l", "organism": "Mouse", "refseq_name": "embryonic polyadenylate-binding protein 2", "refseq_ac": "NP_001007463", "gene_names_uniprotkb": "Pabpn1l; Epabp2; Gm1108; Pabpnl1", "gene_names_refseq": "Gm1108; Pabpn1l; Pabpnl1; ePABP2", "protein_names_uniprotkb": "Embryonic polyadenylate-binding protein 2; Embryonic poly(A)-binding protein 2; Embryonic poly(A)-binding protein type II; Poly(A)-binding protein nuclear-like 1; ePABP-2; ePABP2", "protein_names_refseq": "T-cell receptor alpha chain V region (8/10-2); ePABP-2; embryonic poly(A) binding protein 2; embryonic poly(A)-binding protein type II; embryonic polyadenylate-binding protein 2; poly(A)-binding protein nuclear-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:382035)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10725249;10922068;11544199;15083517;34726234;38057116;40885482", "class_list": "", "function": "Binds the poly(A) tail of mRNA., [UniProtKB, UniProtKB]; PABPN1L assemble into ''ring-like'' aggregates in the cytoplasm of MII oocytes and is associated with female infertilitydagger., [RefSeq, PubMed]; PABPN1L is required for maternal mRNA degradation after meiosis resumption., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ43", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0031397 negative regulation of protein ubiquitination;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0062026 negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process;GO:0160021 maternal-to-zygotic transition of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5XFR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61772-1", "uniprot_id": "EPHA7_MOUSE", "mass": 111860.0, "length": 998, "protein_name": "Ephrin type-A receptor 7", "gene_name": "Epha7", "organism": "Mouse", "refseq_name": "ephrin type-A receptor 7 isoform 3 precursor", "refseq_ac": "NP_001277363", "gene_names_uniprotkb": "Epha7; Ebk; Ehk3; Mdk1", "gene_names_refseq": "Cek11; Ebk; Ehk3; Epha7; Hek11; Mdk1", "protein_names_uniprotkb": "Ephrin type-A receptor 7; 2.7.10.1; Developmental kinase 1; EBK; EHK-3; EPH homology kinase 3; Embryonic brain kinase; mDK-1", "protein_names_refseq": "EPH homology kinase 3; developmental kinase 1; embryonic brain kinase; ephrin type-A receptor 7 isoform 3 precursor; ephrin type-A receptor 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:13841); (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11089974;15902206;15996548;16301174;21750661;27446912;37828378;7824284;8541219;9368721;9883737", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61505;Q61773;Q61774;Q8BSU8", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;3.6.5.2;2.7.11.23", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046875 ephrin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0043065 positive regulation of apoptotic process;GO:0048013 ephrin receptor signaling pathway;GO:0006915 apoptotic process;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61772-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DI86-1", "uniprot_id": "FAKD1_MOUSE", "mass": 95398.0, "length": 829, "protein_name": "FAST kinase domain-containing protein 1, mitochondrial", "gene_name": "Fastkd1", "organism": "Mouse", "refseq_name": "FAST kinase domain-containing protein 1, mitochondrial", "refseq_ac": "NP_796218", "gene_names_uniprotkb": "Fastkd1; Kiaa1800", "gene_names_refseq": "5330408N05Rik; Fastkd1; mKIAA1800", "protein_names_uniprotkb": "FAST kinase domain-containing protein 1, mitochondrial", "protein_names_refseq": "FAST kinase domain-containing protein 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:320720)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20869947;25428506;31268778", "class_list": "", "function": "FASTKD1 supports mitochondrial homeostasis and plays a critical role against oxidant-induced death., [RefSeq, PubMed]; Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR00;B0R0D3;Q5DTU7;Q6IS39;Q8BSV8;Q8C429;Q8R1N6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0000959 mitochondrial RNA metabolic process;GO:0044528 regulation of mitochondrial mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DI86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZE7-1", "uniprot_id": "PBIR2_MOUSE", "mass": 27686.0, "length": 255, "protein_name": "PABIR family member 2", "gene_name": "Pabir2", "organism": "Mouse", "refseq_name": "PABIR family member 2 isoform 1", "refseq_ac": "NP_001159837", "gene_names_uniprotkb": "Pabir2; Fam122b", "gene_names_refseq": "4632404H22Rik; Fam122b; Pabir2; SPACIA2", "protein_names_uniprotkb": "PABIR family member 2", "protein_names_refseq": "PABIR family member 2 isoform 1; family with sequence similarity 122, member B; protein FAM122B; synoviocyte proliferation associated in collagen-induced arthritis 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78755)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;34203471", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1B0Y4;B1B0Y5;Q8BRG5;Q8CBB0;Q9D2N2", "ec_number_list": "", "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NZE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1G6-1", "uniprot_id": "F167A_MOUSE", "mass": 24319.0, "length": 215, "protein_name": "Protein FAM167A", "gene_name": "Fam167a", "organism": "Mouse", "refseq_name": "protein FAM167A", "refseq_ac": "NP_808296", "gene_names_uniprotkb": "Fam167a", "gene_names_refseq": "A030013D21; Fam167a", "protein_names_uniprotkb": "Protein FAM167A", "protein_names_refseq": "protein FAM167A", "tax_id": 10090, "disease": "", "pathway": " (mmu:219148)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35241148", "class_list": "", "function": "FAM167A is a key molecule to induce BCR-ABL-independent TKI resistance in CML via noncanonical NF-kappaB signaling activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P1G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGH4-1", "uniprot_id": "F222A_MOUSE", "mass": 47233.0, "length": 453, "protein_name": "Protein FAM222A", "gene_name": "Fam222a", "organism": "Mouse", "refseq_name": "protein FAM222A", "refseq_ac": "NP_001004180", "gene_names_uniprotkb": "Fam222a", "gene_names_refseq": "Fam222a", "protein_names_uniprotkb": "Protein FAM222A", "protein_names_refseq": "protein FAM222A", "tax_id": 10090, "disease": "", "pathway": " (mmu:433940)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;31964863;37942611", "class_list": "", "function": "FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report., [RefSeq, PubMed]; Study reports FAM222A as a putative brain atrophy susceptibility gene. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with Alzheimer's disease (AD) and in an AD mouse model. It accumulates within amyloid deposits, physically interacts with amyloid-beta (Abeta) via its N-terminal Abeta binding domain and facilitates Abeta aggregation. Erratum:[Nat Commun. 2022 Jul 11;13(1):4006. doi: 10.1038/s41467-022-31711-8. PMID: 35817794] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PGH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPG5-1", "uniprot_id": "TAFA4_MOUSE", "mass": 15018.0, "length": 135, "protein_name": "Chemokine-like protein TAFA-4", "gene_name": "Tafa4", "organism": "Mouse", "refseq_name": "chemokine-like protein TAFA-4 precursor", "refseq_ac": "NP_796207", "gene_names_uniprotkb": "Tafa4; Fam19a4", "gene_names_refseq": "C130034I18Rik; Fam19a4 Tafa-4; Fam19a4; Tafa-4; Tafa4", "protein_names_uniprotkb": "Chemokine-like protein TAFA-4", "protein_names_refseq": "chemokine-like protein TAFA-4 precursor; chemokine-like protein TAFA-4; family with sequence similarity 19 (chemokine (C-C motif)-like), member A4; family with sequence similarity 19, member A4; protein FAM19A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:320701)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15028294;24139797;25109685;34706225;36368013", "class_list": "", "function": "Modulates injury-induced and chemical pain hypersensitivity (PubMed:24139797). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685)., [UniProtKB, PubMed, PubMed]; Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcepsilonRI in mast cells., [RefSeq, PubMed]; TAFA4 is required to maintain the normal threshold of injury-induced mechanical and chemical pain hypersensitivity and strongly support a potential role of TAFA4 as a potent analgesic in the settings of inflammation and neuropathy., [RefSeq, PubMed]; TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWC0;Q8BV02", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0006909 phagocytosis;GO:0051930 regulation of sensory perception of pain;GO:0010469 regulation of signaling receptor activity;GO:0048246 macrophage chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TPG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TA9-1", "uniprot_id": "EPG5_MOUSE", "mass": 290801.0, "length": 2572, "protein_name": "Ectopic P granules protein 5 homolog", "gene_name": "Epg5", "organism": "Mouse", "refseq_name": "ectopic P granules protein 5 homolog", "refseq_ac": "NP_001182562", "gene_names_uniprotkb": "Epg5; Kiaa1632", "gene_names_refseq": "4732475F16; 5430411K18Rik; Epg5", "protein_names_uniprotkb": "Ectopic P granules protein 5 homolog", "protein_names_refseq": "ectopic P granules protein 5 homolog; ectopic P-granules autophagy protein 5 homolog", "tax_id": 10090, "disease": "Vici syndrome (Disease Ontology:DOID:0060356); retinitis pigmentosa (Disease Ontology:DOID:10584); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:100502841)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "20485683;23479740;25428506;27715390;27802388;28011936;30084848;31219806;34428180;34520306;35786405;35820727;36210013;37828378", "class_list": "", "function": "Apoptotic photoreceptor cell death in epg5(-/-) retinas may result from the elevated unfolded protein response., [RefSeq, PubMed]; Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells., [RefSeq, PubMed]; Epg5-deficient mice as a model for investigating the pathogenesis of ALS and indicates that dysfunction of the autophagic-endolysosomal system causes selective damage of neurons associated with neurodegenerative diseases., [RefSeq, PubMed]; Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota., [RefSeq, PubMed]; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0048877 homeostasis of number of retina cells;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80TA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X91-1", "uniprot_id": "F110D_MOUSE", "mass": 28712.0, "length": 271, "protein_name": "Protein FAM110D", "gene_name": "Fam110d", "organism": "Mouse", "refseq_name": "protein FAM110D", "refseq_ac": "NP_001092766", "gene_names_uniprotkb": "Fam110d; Grrp1", "gene_names_refseq": "2810043G13Rik; Fam110d; Grrp1", "protein_names_uniprotkb": "Protein FAM110D", "protein_names_refseq": "glycine/arginine rich protein 1; protein FAM110D", "tax_id": 10090, "disease": "", "pathway": " (mmu:72690)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80X91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YR2-1", "uniprot_id": "FHI2B_MOUSE", "mass": 82456.0, "length": 744, "protein_name": "FHF complex subunit HOOK-interacting protein 2B", "gene_name": "Fhip2b", "organism": "Mouse", "refseq_name": "FHF complex subunit HOOK-interacting protein 2B", "refseq_ac": "NP_919326", "gene_names_uniprotkb": "Fhip2b; Fam160b2; Rai16", "gene_names_refseq": "Fam160b2; Fhip2b; G430067P06Rik; Rai16", "protein_names_uniprotkb": "FHF complex subunit HOOK-interacting protein 2B; Retinoic acid-induced protein 16", "protein_names_refseq": "FHF complex subunit HOOK-interacting protein 2B; family with sequence similarity 160, member B2; protein FAM160B2; retinoic acid induced 16; retinoic acid-induced protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:239170)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31862898;32289885;36210013", "class_list": "", "function": "Able to activate MAPK/ERK and TGFB signaling pathways (By similarity). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (PubMed:31862898). May play a role in cell proliferation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Retinoic acid induced 16 deficiency exacerbates high-fat diet-induced steatohepatitis in mice., [RefSeq, PubMed]; Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PED9;Q8C1Y2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80YR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHL6-1", "uniprot_id": "FAP24_MOUSE", "mass": 24641.0, "length": 221, "protein_name": "Fanconi anemia core complex-associated protein 24", "gene_name": "Faap24", "organism": "Mouse", "refseq_name": "Fanconi anemia core complex-associated protein 24", "refseq_ac": "NP_848758", "gene_names_uniprotkb": "Faap24", "gene_names_refseq": "C230052I12Rik; Faap24", "protein_names_uniprotkb": "Fanconi anemia core complex-associated protein 24; Fanconi anemia-associated protein of 24 kDa", "protein_names_refseq": "Fanconi anemia core complex-associated protein 24; Fanconi anemia-associated protein, 24 kDa; fanconi anemia-associated protein of 24 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:101831); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "31219806;34428180", "class_list": "", "function": "Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLJ2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0071821 FANCM-MHF complex;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHR2-1", "uniprot_id": "ENOX1_MOUSE", "mass": 73281.0, "length": 643, "protein_name": "Ecto-NOX disulfide-thiol exchanger 1", "gene_name": "Enox1", "organism": "Mouse", "refseq_name": "ecto-NOX disulfide-thiol exchanger 1 isoform 1", "refseq_ac": "NP_001240688", "gene_names_uniprotkb": "Enox1", "gene_names_refseq": "B230207J08; D230005D02Rik; Enox1", "protein_names_uniprotkb": "Ecto-NOX disulfide-thiol exchanger 1; Constitutive Ecto-NOX; cNOX", "protein_names_refseq": "cNOX; constitutive Ecto-NOX; ecto-NOX disulfide-thiol exchanger 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239188)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18462883;21750661;25428506;27788492", "class_list": "", "function": "Enox1 in tumor stroma significantly enhances the effectiveness of 2 Gy fractionated radiotherapy and identifies Enox1 as a potential therapeutic target., [RefSeq, PubMed]; Lithium at physiological concentrations induces an ECTO-NOX activity previously inactive from plant (soybean), murine (3T3 cells) and human (HUVEC and HeLa cells) sources and resets the period of the constitutive CNOX., [RefSeq, PubMed]; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WS5", "ec_number_list": "", "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0003723 RNA binding;GO:0003756 protein disulfide isomerase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007624 ultradian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BHR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJW7-1", "uniprot_id": "EME1_MOUSE", "mass": 63481.0, "length": 570, "protein_name": "Structure-specific endonuclease subunit EME1", "gene_name": "Eme1", "organism": "Mouse", "refseq_name": "structure-specific endonuclease subunit EME1 isoform 2", "refseq_ac": "NP_808420", "gene_names_uniprotkb": "Eme1", "gene_names_refseq": "6820428D13; Eme1", "protein_names_uniprotkb": "Structure-specific endonuclease subunit EME1", "protein_names_refseq": "crossover junction endonuclease EME1; essential meiotic endonuclease 1 homolog 1; structure-specific endonuclease subunit EME1 isoform 2; structure-specific endonuclease subunit EME1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268465); (R-MMU-5693568); (R-MMU-6783310)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14609959;17036055;18692478;27010503;31170160;31219806;40885482", "class_list": "", "function": "Double mutant mice homozygous for the Mlh3DN/DN and Mus81-/- mutations show losses in chiasmata close to those observed in Mlh3-/- males, indicating that the MUS81-EME1-regulated crossover pathway can only partially account for the increased residual chiasmata in Mlh3DN/DN spermatocytes Publication Status: Online-Only, [RefSeq, PubMed]; Mus81-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway, [RefSeq, PubMed]; Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME1 which is involved in the maintenance of genome stability (PubMed:14609959). In the complex, EME1 is required for DNA cleavage, participating in DNA recognition and bending. MUS81-EME1 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. Active during prometaphase, MUS81-EME1 resolves mitotic recombination intermediates, including Holliday junctions, which form during homologous recombination (By similarity)., [UniProtKB, UniProtKB, PubMed]; These findings link Eme1 with the replication-associated chromatin modifier functions of Np95 in the cellular response to DNA damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0008821 crossover junction DNA endonuclease activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0000228 nuclear chromosome;GO:0000792 heterochromatin", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006302 double-strand break repair;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0072429 response to intra-S DNA damage checkpoint signaling;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BJW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BK48-1", "uniprot_id": "EST2E_MOUSE", "mass": 62318.0, "length": 559, "protein_name": "Pyrethroid hydrolase Ces2e", "gene_name": "Ces2e", "organism": "Mouse", "refseq_name": "pyrethroid hydrolase Ces2e precursor", "refseq_ac": "NP_001157228", "gene_names_uniprotkb": "Ces2e; Ces5", "gene_names_refseq": "9030624L02Rik; Ces2e; Ces5", "protein_names_uniprotkb": "Pyrethroid hydrolase Ces2e; 3.1.1.-; 3.1.1.88; Carboxylic ester hydrolase; carboxylesterase 2E", "protein_names_refseq": "carboxylesterase 5; carboxylic ester hydrolase; pyrethroid hydrolase Ces2e precursor; pyrethroid hydrolase Ces2e", "tax_id": 10090, "disease": "", "pathway": " (mmu:234673)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15123619;17208939;18630941;40997131", "class_list": "", "function": "Carboxylesterase that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes trans-permethrin at a rate about 22-fold higher than cis-permethrin. Also hydrolyzes trans-cypermethrin. Hydrolyzes retinyl esters (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM97;Q8VC02", "ec_number_list": "3.1.1.23;3.1.1.79;3.1.1.1;3.1.1.-;3.1.1.3;3.1.1.88;3.1.1.67;3.1.1.28", "go_molecular_function": "GO:0102209 trans-permethrin hydrolase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006693 prostaglandin metabolic process;GO:0098754 detoxification;GO:0050784 cocaine catabolic process;GO:0071273 morphine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BK48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXQ8-1", "uniprot_id": "FA53C_MOUSE", "mass": 43261.0, "length": 393, "protein_name": "Protein FAM53C", "gene_name": "Fam53c", "organism": "Mouse", "refseq_name": "protein FAM53C isoform 1", "refseq_ac": "NP_780313", "gene_names_uniprotkb": "Fam53c", "gene_names_refseq": "2810012G03Rik; Fam53c; Gm21179", "protein_names_uniprotkb": "Protein FAM53C", "protein_names_refseq": "protein FAM53C isoform 1; protein FAM53C", "tax_id": 10090, "disease": "", "pathway": " (mmu:66306)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;30084848;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4J2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BXQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C152-1", "uniprot_id": "TET5B_MOUSE", "mass": 46998.0, "length": 427, "protein_name": "Terminal nucleotidyltransferase 5B", "gene_name": "Tent5b", "organism": "Mouse", "refseq_name": "terminal nucleotidyltransferase 5B", "refseq_ac": "NP_780516", "gene_names_uniprotkb": "Tent5b; Fam46b", "gene_names_refseq": "4732473B16Rik; Fam46b; Tent5b", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5B; 2.7.7.19; Non-canonical poly(A) polymerase FAM46B", "protein_names_refseq": "family with sequence similarity 46, member B; non-canonical poly(A) polymerase FAM46B; protein FAM46B; putative nucleotidyltransferase FAM46B; terminal nucleotidyltransferase 5B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100342)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner. May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs. Prefers RNA molecules that are adenosine-rich close to 3'-end. In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSC3;Q8CI10", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0048255 mRNA stabilization;GO:0045727 positive regulation of translation;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C460-1", "uniprot_id": "ERI3_MOUSE", "mass": 37189.0, "length": 337, "protein_name": "ERI1 exoribonuclease 3", "gene_name": "Eri3", "organism": "Mouse", "refseq_name": "ERI1 exoribonuclease 3 isoform b", "refseq_ac": "NP_001272828", "gene_names_uniprotkb": "Eri3; Pint1; Prnpip1; Prnpip", "gene_names_refseq": "Eri3; PINT1; Prnpip1", "protein_names_uniprotkb": "ERI1 exoribonuclease 3; 3.1.-.-; Prion interactor 1; Prion protein-interacting protein", "protein_names_refseq": "ERI1 exoribonuclease 3 isoform b; ERI1 exoribonuclease 3; prion interactor 1; prion protein interacting protein 1; prion protein-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:140546)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11571277;21750661;22039495;24129315", "class_list": "", "function": "Hd-siRNAs also abolish the 3' untranslated region (UTR) mediated posttranscriptional repression of meri-1. Our findings demonstrate the molecular mechanism underlying the upregulation of meri-1 by hd-siRNA, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADW0;A2ADW2;Q149R0;Q68FL7;Q923K5", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0060906 negative regulation of regulatory ncRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C552-1", "uniprot_id": "FA78A_MOUSE", "mass": 32068.0, "length": 283, "protein_name": "Protein FAM78A", "gene_name": "Fam78a", "organism": "Mouse", "refseq_name": "protein FAM78A", "refseq_ac": "NP_780720", "gene_names_uniprotkb": "Fam78a", "gene_names_refseq": "A130092J06Rik; Fam78a", "protein_names_uniprotkb": "Protein FAM78A", "protein_names_refseq": "protein FAM78A", "tax_id": 10090, "disease": "", "pathway": " (mmu:241303)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6C7-1", "uniprot_id": "F204A_MOUSE", "mass": 26995.0, "length": 236, "protein_name": "Protein FAM204A", "gene_name": "Fam204a", "organism": "Mouse", "refseq_name": "protein FAM204A isoform 1", "refseq_ac": "NP_083924", "gene_names_uniprotkb": "Fam204a; D19Ertd737e", "gene_names_refseq": "2310065H12Rik; 2610015K05Rik; D19Ertd737e; Fam204a", "protein_names_uniprotkb": "Protein FAM204A", "protein_names_refseq": "protein FAM204A isoform 1; protein FAM204A", "tax_id": 10090, "disease": "", "pathway": " (mmu:76539)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C6C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCS2-1", "uniprot_id": "NALF1_MOUSE", "mass": 52739.0, "length": 467, "protein_name": "NALCN channel auxiliary factor 1", "gene_name": "Nalf1", "organism": "Mouse", "refseq_name": "NALCN channel auxiliary factor 1 isoform 2", "refseq_ac": "NP_001334056", "gene_names_uniprotkb": "Nalf1; Fam155a", "gene_names_refseq": "6430500D16; Fam155a; Nalf1; Tmem28", "protein_names_uniprotkb": "NALCN channel auxiliary factor 1; Transmembrane protein FAM155A", "protein_names_refseq": "NALCN channel auxiliary factor 1 isoform 2; family with sequence similarity 155, member A; transmembrane protein 28; transmembrane protein FAM155A", "tax_id": 10090, "disease": "", "pathway": " (mmu:270028)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;33273469", "class_list": "", "function": "Auxilary subunit component of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (By similarity). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity)., [UniProtKB, UniProtKB]; Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q149R3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0098703 calcium ion import across plasma membrane;GO:0098908 regulation of neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CCS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CF27-1", "uniprot_id": "FA24A_MOUSE", "mass": 10857.0, "length": 98, "protein_name": "Protein FAM24A", "gene_name": "Fam24a", "organism": "Mouse", "refseq_name": "protein FAM24A precursor", "refseq_ac": "NP_899095", "gene_names_uniprotkb": "Fam24a", "gene_names_refseq": "1700063I17Rik; 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Fam13b1", "gene_names_refseq": "2610024E20Rik; Fam13b", "protein_names_uniprotkb": "Protein FAM13B", "protein_names_refseq": "protein FAM13B isoform 1; protein FAM13B", "tax_id": 10090, "disease": "", "pathway": " (mmu:225358); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K2H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2P2-1", "uniprot_id": "FA83A_MOUSE", "mass": 48193.0, "length": 436, "protein_name": "Protein FAM83A", "gene_name": "Fam83a", "organism": "Mouse", "refseq_name": "protein FAM83A", "refseq_ac": "NP_776287", "gene_names_uniprotkb": "Fam83a", "gene_names_refseq": "Fam83a; Sack1a", "protein_names_uniprotkb": "Protein FAM83A", "protein_names_refseq": "family with sequence similarity 83, member A; protein FAM83A", "tax_id": 10090, "disease": "", "pathway": " (mmu:239463); (R-MMU-177929)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "35931121", "class_list": "", "function": "Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function., [UniProtKB, PubMed]; Proto-oncogene FAM83A contributes to casein kinase 1-mediated mitochondrial maintenance and white adipocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0008283 cell population proliferation;GO:0050872 white fat cell differentiation;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2P2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZR3-1", "uniprot_id": "EST2A_MOUSE", "mass": 61940.0, "length": 558, "protein_name": "Pyrethroid hydrolase Ces2a", "gene_name": "Ces2a", "organism": "Mouse", "refseq_name": "pyrethroid hydrolase Ces2a isoform 2 precursor", "refseq_ac": "NP_001177259", "gene_names_uniprotkb": "Ces2a; Ces6", "gene_names_refseq": "9130231C15Rik; Ces2a; Ces6", "protein_names_uniprotkb": "Pyrethroid hydrolase Ces2a; 3.1.1.-; 3.1.1.88; Carboxylic ester hydrolase 2A; carboxylesterase 2A", "protein_names_refseq": "carboxylesterase 6; carboxylic ester hydrolase 2A; pyrethroid hydrolase Ces2a isoform 2 precursor; pyrethroid hydrolase Ces2a", "tax_id": 10090, "disease": "", "pathway": " (mmu:102022)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15123619;21750661;23806337;34428180;40997131", "class_list": "glycogene", "function": "Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin. Hydrolyzes retinyl esters (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 55, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q3D0;Q3TMR2", "ec_number_list": "3.1.1.23;3.1.1.79;3.1.1.1;3.1.1.-;3.1.1.3;3.1.1.88;3.1.1.67;3.1.1.28", "go_molecular_function": "GO:0102209 trans-permethrin hydrolase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006693 prostaglandin metabolic process;GO:0098754 detoxification;GO:0050784 cocaine catabolic process;GO:0071273 morphine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8QZR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R184-1", "uniprot_id": "F110A_MOUSE", "mass": 31582.0, "length": 296, "protein_name": "Protein FAM110A", "gene_name": "Fam110a", "organism": "Mouse", "refseq_name": "protein FAM110A", "refseq_ac": "NP_001276079", "gene_names_uniprotkb": "Fam110a", "gene_names_refseq": "1700008J10Rik; 5430432M24Rik; Fam110a", "protein_names_uniprotkb": "Protein FAM110A", "protein_names_refseq": "protein FAM110A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73847)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17499476", "class_list": "", "function": "Localization and preliminary characterization of human homologs, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q505P3;Q8BQE5;Q8K024;Q8VEM7;Q9CU80", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R313-1", "uniprot_id": "EXOC6_MOUSE", "mass": 93077.0, "length": 802, "protein_name": "Exocyst complex component 6", "gene_name": "Exoc6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Exoc6; Sec15a; Sec15l1", "gene_names_refseq": "", "protein_names_uniprotkb": "Exocyst complex component 6; Exocyst complex component Sec15A; SEC15-like protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15292201;21750661;34428180", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0090543 Flemming body;GO:0000145 exocyst", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030218 erythrocyte differentiation;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCC2-1", "uniprot_id": "EST1_MOUSE", "mass": 62680.0, "length": 565, "protein_name": "Liver carboxylesterase 1", "gene_name": "Ces1", "organism": "Mouse", "refseq_name": "liver carboxylesterase 1 precursor", "refseq_ac": "NP_067431", "gene_names_uniprotkb": "Ces1; Ces1g", "gene_names_refseq": "CEH; Ces-1; Ces1g; Ces1; Ses-1", "protein_names_uniprotkb": "Liver carboxylesterase 1; 3.1.1.13; 3.1.1.1; Acyl-coenzyme A:cholesterol acyltransferase; CEH; Carboxylesterase 1G; Cholesteryl ester hydrolase; ES-x", "protein_names_refseq": "ES-x; acyl-coenzyme A:cholesterol acyltransferase; cholesteryl ester hydrolase; liver carboxylesterase 1 precursor; liver carboxylesterase 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stomach cancer (Disease Ontology:DOID:10534); gastrointestinal system cancer (Disease Ontology:DOID:3119); liver cancer (Disease Ontology:DOID:3571); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12623)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24194565;26976727;27881673;29259301;34428180;9565681", "class_list": "glycogene", "function": "Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses., [RefSeq, PubMed]; Global loss of Ces1/Ces1g protects against the development of atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin sensitivity., [RefSeq, PubMed]; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile., [UniProtKB, UniProtKB]; Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury., [RefSeq, PubMed]; This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O55136", "ec_number_list": "3.5.1.99;3.1.1.-;3.1.1.23;3.1.1.1;3.1.1.79;3.1.1.5;3.1.1.13;3.1.1.3;3.1.1.6;3.1.1.71;3.1.1.67;3.1.-.-;3.3.2.9;3.1.2.22;3.1.2.-", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0010887 negative regulation of cholesterol storage;GO:0043691 reverse cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCU1-1", "uniprot_id": "EST3B_MOUSE", "mass": 63353.0, "length": 571, "protein_name": "Carboxylesterase 3B", "gene_name": "Ces3b", "organism": "Mouse", "refseq_name": "carboxylesterase 3B isoform 2 precursor", "refseq_ac": "NP_001152887", "gene_names_uniprotkb": "Ces3b; Gm4738", "gene_names_refseq": "Ces31L; Ces3L; Ces3b; EG13909; ES31L; Es31; Gm4738", "protein_names_uniprotkb": "Carboxylesterase 3B; 3.1.1.1; Liver carboxylesterase 31-like", "protein_names_refseq": "carboxylesterase 3B isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:13909); (R-MMU-211945); (R-MMU-8964038)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;37453647", "class_list": "", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E8G7;G5E8K9;Q91XD5", "ec_number_list": "3.1.1.1;3.1.1.-;3.1.1.13;3.1.1.67", "go_molecular_function": "GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEG4-1", "uniprot_id": "EXD2_MOUSE", "mass": 74332.0, "length": 650, "protein_name": "Exonuclease 3'-5' domain-containing protein 2", "gene_name": "Exd2", "organism": "Mouse", "refseq_name": "exonuclease 3'-5' domain-containing protein 2", "refseq_ac": "NP_598559", "gene_names_uniprotkb": "Exd2; Exdl2", "gene_names_refseq": "4930539P14Rik; Exd2; Exdl2", "protein_names_uniprotkb": "Exonuclease 3'-5' domain-containing protein 2; 3'-5' exoribonuclease EXD2; 3.1.11.1; 3.1.13.-; Exonuclease 3'-5' domain-like-containing protein 2", "protein_names_refseq": "3'-5' exoribonuclease EXD2; exonuclease 3''-5'' domain-like 2; exonuclease 3'-5' domain-containing protein 2; exonuclease 3'-5' domain-like-containing protein 2", "tax_id": 10090, "disease": "Werner syndrome (Disease Ontology:DOID:5688)", "pathway": " (mmu:97827)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22872234;25428506;30084848;31219806;31599954;34428180;36624638", "class_list": "", "function": "Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation., [UniProtKB, UniProtKB]; Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WID1;Q3TPJ5;Q3TS84", "ec_number_list": "", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006302 double-strand break repair;GO:0000724 double-strand break repair via homologous recombination;GO:0000729 DNA double-strand break processing;GO:0031297 replication fork processing;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VEG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WE9-1", "uniprot_id": "TAFA5_MOUSE", "mass": 14331.0, "length": 132, "protein_name": "Chemokine-like protein TAFA-5", "gene_name": "Tafa5", "organism": "Mouse", "refseq_name": "chemokine-like protein TAFA-5 isoform 1 precursor", "refseq_ac": "NP_001239239", "gene_names_uniprotkb": "Tafa5; Fam19a5", "gene_names_refseq": "Fam19a5; Tafa-5; Tafa5; Tara-5", "protein_names_uniprotkb": "Chemokine-like protein TAFA-5", "protein_names_refseq": "chemokine-like protein TAFA-5 isoform 1 precursor; chemokine-like protein TAFA-5; family with sequence similarity 19, member A5; protein FAM19A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:106014)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15028294;29138422;29453251;31954515", "class_list": "", "function": "Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29138422, PubMed:29453251). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (PubMed:29138422). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (PubMed:29138422). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (PubMed:29138422). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251)., [UniProtKB, PubMed, PubMed, UniProtKB]; Brain-specific chemokine FAM19A5 induces hypothalamic inflammation., [RefSeq, PubMed]; This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1V6", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0061044 negative regulation of vascular wound healing;GO:0007186 G protein-coupled receptor signaling pathway;GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation;GO:1904753 negative regulation of vascular associated smooth muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91WE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WG0-1", "uniprot_id": "EST2C_MOUSE", "mass": 62470.0, "length": 561, "protein_name": "Acylcarnitine hydrolase", "gene_name": "Ces2c", "organism": "Mouse", "refseq_name": "acylcarnitine hydrolase precursor", "refseq_ac": "NP_663578", "gene_names_uniprotkb": "Ces2c; Ces2", "gene_names_refseq": "ACH M1; CES 2; Ces2c; Ces2; ces2A3", "protein_names_uniprotkb": "Acylcarnitine hydrolase; 3.1.1.-; 3.1.1.28; ACH M1; CES 2; Carboxylesterase 2; Carboxylic ester hydrolase; Peroxisome proliferator-inducible acylcarnitine hydrolase", "protein_names_refseq": "acylcarnitine hydrolase M1; acylcarnitine hydrolase precursor; carboxylesterase 2; carboxylesterase ML3; carboxylic ester hydrolase; peroxisome proliferator-inducible acylcarnitine hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:234671)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12859986;16527247;28011936;34428180", "class_list": "glycogene", "function": "Hydrolase with high activity towards palmitoylcarnitine. Is also active with p-nitrophenylacetate and alpha-naphthylacetate. May also hydrolyze retinyl esters (By similarity)., [UniProtKB, UniProtKB, PubMed]; Purified and characterized an acylcarnitine hydrolase (ACH M1) from liver microsomes, cloned the cDNA named mCES2, expressed it in Sf9 cells and characterized it, [RefSeq, PubMed]; These findings show that HNF-4alpha plays an important role in the regulation of mCES2 gene transcription., [RefSeq, PubMed]; This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. The transcription of this gene is regulated by several factors including HNF-4alpha (hepatocyte nuclear factor-4alpha), Sp1 (specificity protein 1), Sp3 and USF1 (upstream stimulatory factor 1). The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with several family members including a few of pseudogenes and Ces5 on chromosome 8.[provided by RefSeq, Jun 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 40, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.23;3.1.1.79;3.1.1.1;3.1.1.-;3.1.1.3;3.1.1.88;3.1.1.67;3.1.1.28", "go_molecular_function": "GO:0047619 acylcarnitine hydrolase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0006693 prostaglandin metabolic process;GO:0098754 detoxification;GO:0050784 cocaine catabolic process;GO:0071273 morphine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91WG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YN1-1", "uniprot_id": "F118A_MOUSE", "mass": 40475.0, "length": 357, "protein_name": "Protein FAM118A", "gene_name": "Fam118a", "organism": "Mouse", "refseq_name": "protein FAM118A isoform 2", "refseq_ac": "NP_598511", "gene_names_uniprotkb": "Fam118a", "gene_names_refseq": "Fam118a; Siral2", "protein_names_uniprotkb": "Protein FAM118A", "protein_names_refseq": "family with sequence similarity 118, member A; protein FAM118A isoform 2; protein FAM118A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73225)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34203471", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP97;Q8C4H6;Q8C5E1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91YN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921I9-1", "uniprot_id": "EXOS4_MOUSE", "mass": 26250.0, "length": 245, "protein_name": "Exosome complex component RRP41", "gene_name": "Exosc4", "organism": "Mouse", "refseq_name": "exosome complex component RRP41", "refseq_ac": "NP_780608", "gene_names_uniprotkb": "Exosc4; Rrp41", "gene_names_refseq": "1110039I09Rik; 1500001N04Rik; Exosc4; Rrp41", "protein_names_uniprotkb": "Exosome complex component RRP41; Exosome component 4; Ribosomal RNA-processing protein 41", "protein_names_refseq": "exosome complex component RRP41; exosome complex exonuclease RRP41; ribosomal RNA-processing protein 41", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (mmu:109075); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542B0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006396 RNA processing;GO:0030307 positive regulation of cell growth;GO:0051607 defense response to virus;GO:0000956 nuclear-transcribed mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q921I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQE7-1", "uniprot_id": "ERGI3_MOUSE", "mass": 43208.0, "length": 383, "protein_name": "Endoplasmic reticulum-Golgi intermediate compartment protein 3", "gene_name": "Ergic3", "organism": "Mouse", "refseq_name": "endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 3", "refseq_ac": "NP_079792", "gene_names_uniprotkb": "Ergic3; Erv46; Sdbcag84", "gene_names_refseq": "2310015B14Rik; CGI-54; D2Ucla1; Ergic3; NY-BR-84; Sdbcag84", "protein_names_uniprotkb": "Endoplasmic reticulum-Golgi intermediate compartment protein 3; Serologically defined breast cancer antigen NY-BR-84 homolog", "protein_names_refseq": "endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 3; endoplasmic reticulum-Golgi intermediate compartment protein 3; serologically defined breast cancer antigen 84; serologically defined breast cancer antigen NY-BR-84 homolog", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:66366)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12663859;18299400;21750661;21952136;25428506;30084848;30779550;30899004;31219806;34428180;34994051", "class_list": "", "function": "ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans., [RefSeq, PubMed]; Plays a role in transport between endoplasmic reticulum and Golgi., [UniProtKB, UniProtKB, UniProtKB]; Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins alpha1-antitrypsin/SERPINA1 and HP/haptoglobin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B7ZCN9;Q6PGA7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CQE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQM2-1", "uniprot_id": "ERD22_MOUSE", "mass": 24454.0, "length": 212, "protein_name": "ER lumen protein-retaining receptor 2", "gene_name": "Kdelr2", "organism": "Mouse", "refseq_name": "ER lumen protein-retaining receptor 2", "refseq_ac": "NP_080117", "gene_names_uniprotkb": "Kdelr2", "gene_names_refseq": "1110007A14Rik; Kdelr2", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2", "protein_names_refseq": "ER lumen protein-retaining receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2", "tax_id": 10090, "disease": "osteogenesis imperfecta type 21 (Disease Ontology:DOID:0112201)", "pathway": " (mmu:66913); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FK20", "ec_number_list": "", "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen;GO:0035437 maintenance of protein localization in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1Q6-1", "uniprot_id": "ERP44_MOUSE", "mass": 46853.0, "length": 406, "protein_name": "Endoplasmic reticulum resident protein 44", "gene_name": "Erp44", "organism": "Mouse", "refseq_name": "endoplasmic reticulum resident protein 44 isoform 1 precursor", "refseq_ac": "NP_083848", "gene_names_uniprotkb": "Erp44; Kiaa0573; Txndc4", "gene_names_refseq": "1110001E24Rik; Erp44; Txndc4", "protein_names_uniprotkb": "Endoplasmic reticulum resident protein 44; ER protein 44; ERp44; Thioredoxin domain-containing protein 4", "protein_names_refseq": "ER protein 44; endoplasmic reticulum resident protein 44 isoform 1 precursor; endoplasmic reticulum resident protein 44kDa; endoplasmic reticulum resident protein ERp44; thioredoxin domain containing 4 (endoplasmic reticulum); thioredoxin domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:76299); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15652484;25428506;26495903;26740625;30084848;30779550;31283909;31616917;34428180;35088919;35820727;36288343;37453647", "class_list": "", "function": "ERp44 is required for endocardial cushion development by regulating VEGFA secretion in myocardium., [RefSeq, PubMed]; ERp44(-/-) newborns had lower blood glucose compared to wild-type, [RefSeq, PubMed]; Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVI1;Q6A045", "ec_number_list": "", "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress;GO:0009100 glycoprotein metabolic process;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D1Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3L0-1", "uniprot_id": "F174A_MOUSE", "mass": 19986.0, "length": 190, "protein_name": "Membrane protein FAM174A", "gene_name": "Fam174a", "organism": "Mouse", "refseq_name": "membrane protein FAM174A precursor", "refseq_ac": "NP_080597", "gene_names_uniprotkb": "Fam174a; Tmem157", "gene_names_refseq": "2310044D20Rik; Fam174a; Fam174; Naa6; Tmem157", "protein_names_uniprotkb": "Membrane protein FAM174A; Transmembrane protein 157", "protein_names_refseq": "membrane protein FAM174A precursor; membrane protein FAM174A; transmembrane protein 157", "tax_id": 10090, "disease": "", "pathway": " (mmu:67698)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF92;Q8CC46;Q8VDR1;Q9D238;Q9D6W5;Q9D6Z3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D3L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8B6-1", "uniprot_id": "MIMS2_MOUSE", "mass": 20344.0, "length": 190, "protein_name": "Mitochondrial inner membrane scaffold 2", "gene_name": "Mims2", "organism": "Mouse", "refseq_name": "protein FAM210B, mitochondrial", "refseq_ac": "NP_080188", "gene_names_uniprotkb": "Mims2; Fam210b", "gene_names_refseq": "2010011I20Rik; Fam210b; Mims2", "protein_names_uniprotkb": "Mitochondrial inner membrane scaffold 2; Protein FAM210B, mitochondrial", "protein_names_refseq": "family with sequence similarity 210, member B; protein FAM210B, mitochondrial; transmembrane protein C20orf108 homolog", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:67017)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26968549;30366982;34428180;39000360", "class_list": "", "function": "Deletion of the Mitochondrial Membrane Protein Fam210b Is Associated with the Development of Systemic Lupus Erythematosus. Publication Status: Online-Only, [RefSeq, PubMed]; FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity, [RefSeq, PubMed]; Mitochondrial inner membrane adapter protein essential for terminal erythroid differentiation and heme biosynthesis (PubMed:30366982). Facilitates formation of an oligomeric mitochondrial iron transport complex required for iron acquisition during heme synthesis, although it does not function as a direct iron transporter (PubMed:30366982). Directly interacts with terminal heme synthesis enzymes PPOX and FECH to enhance ferrochelatase activity and couple iron import with heme synthesis (PubMed:30366982). Regulates mitochondrial energy metabolism through interaction with ATP synthase subunits (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFZ3;Q91WA2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006954 inflammatory response;GO:0030218 erythrocyte differentiation;GO:0048536 spleen development;GO:0045648 positive regulation of erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D8B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9V2-1", "uniprot_id": "EQTN_MOUSE", "mass": 37764.0, "length": 337, "protein_name": "Equatorin", "gene_name": "Eqtn", "organism": "Mouse", "refseq_name": "equatorin isoform 2 precursor", "refseq_ac": "NP_001277552", "gene_names_uniprotkb": "Eqtn; Afaf; Mn9", "gene_names_refseq": "1700028B15Rik; 4930579C15Rik; Afaf; Eqtl; Eqtn; Eqts", "protein_names_uniprotkb": "Equatorin; Acrosome formation-associated factor; MN9 antigen", "protein_names_refseq": "MN9 antigen; acrosome formation associated factor; equatorin isoform 2 precursor; sperm-specific single transmembrane domain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67753)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1486600;16831425;19285662;19605790;20032212;23564009;24480441;30328350;9674989", "class_list": "", "function": "Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis., [UniProtKB, PubMed, PubMed, PubMed]; Acrosome formation-associated factor (Afaf) might play an important role in membrane trafficking during acrosome formation and participate in fertilization., [RefSeq, PubMed]; Afaf expressed abundantly in the round spermatids, localized in the inner and outer membrane of forming acrosome, and declined in the maturing acrosomes., [RefSeq, PubMed]; EQUATORIN-deficient sperm have significantly reduced fertility due to sperm-egg adhesion failure. GeneRIF: GeneRIF: EQUATORIN associating with SPESP1 is involved in sperm-egg adhesion leading to male fertility. GeneRIF: Equatorin associating with Spesp1 is involved in sperm-egg adhesion to fusion, which is independent of Izumo1, CD9 and Juno., [RefSeq, PubMed]; Equatorin-based progression model will be useful for analyzing not only the behavior of equatorin but also of other molecules of interest involved in the acrosome reaction., [RefSeq, PubMed]; MN9, a monoclonal antibody raised against mouse spermatozoa, specifically recognizes the equatorial segment of sperm head in several mammalian species, including humans. The immunoreactive bands were 38 kDa and 48 kDa in mouse, and 48 kDa in rat., [RefSeq, PubMed]; The fertilization and induced acrosome exocytosis rates of Eqtn-deficient sperm were dramatically reduced., [RefSeq, PubMed]; The present study aims to clarify the morphology associated with the integration of the mouse fertilization-related acrosomal protein equatorin (mEQT) into the developing acrosome., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AJE0;Q2LCV5;Q5FWB0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0001675 acrosome assembly;GO:0060478 acrosomal vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D9V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAL9-1", "uniprot_id": "FA24L_MOUSE", "mass": 12740.0, "length": 119, "protein_name": "Protein FAM24B", "gene_name": "Fam24b", "organism": "Mouse", "refseq_name": "protein FAM24B precursor", "refseq_ac": "NP_081313", "gene_names_uniprotkb": "Fam24b", "gene_names_refseq": "1700007K09Rik; Fam24b", "protein_names_uniprotkb": "Protein FAM24B; Protein FAM24A-like", "protein_names_refseq": "protein FAM24B precursor; protein FAM24B", "tax_id": 10090, "disease": "", "pathway": " (mmu:69318)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTJ8-1", "uniprot_id": "FA50B_MOUSE", "mass": 39594.0, "length": 334, "protein_name": "Protein FAM50B", "gene_name": "Fam50b", "organism": "Mouse", "refseq_name": "protein FAM50B", "refseq_ac": "NP_620085", "gene_names_uniprotkb": "Fam50b; D0H6S2654E; X5l", "gene_names_refseq": "D0H6S2654E; Fam50b; X5L; XAP-5-like", "protein_names_uniprotkb": "Protein FAM50B; Protein XAP-5-like", "protein_names_refseq": "protein FAM50B", "tax_id": 10090, "disease": "", "pathway": " (mmu:108161)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10534398", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80X84;Q9D993", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045171 intercellular bridge;GO:0030496 midbody", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WTJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUZ9-1", "uniprot_id": "ENTP5_MOUSE", "mass": 47102.0, "length": 427, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 5", "gene_name": "Entpd5", "organism": "Mouse", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor", "refseq_ac": "NP_001021385", "gene_names_uniprotkb": "Entpd5; Cd39l4", "gene_names_refseq": "Cd39l4; ER-UDPase; Entpd5; NTPDase-5; NTPDase5; Pcph; mNTPase", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 5; 3.6.1.6; CD39 antigen-like 4; ER-UDPase; GDPase ENTPD5; Guanosine-diphosphatase ENTPD5; NTPDase 5; Nucleoside diphosphatase; UDPase ENTPD5; Uridine-diphosphatase ENTPD5", "protein_names_refseq": "CD39 antigen-like 4; GDPase ENTPD5; NTPDase 5; UDPase ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor; guanosine-diphosphatase ENTPD5; nucleoside diphosphatase; uridine-diphosphatase ENTPD5", "tax_id": 10090, "disease": "", "pathway": " (mmu:12499); (R-MMU-8850843)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10369669;10506756;19176496;21074248;24859727;34428180;36849424;37453647;40997131;9457681", "class_list": "", "function": "During a study using the embryonic fibroblasts from the PTEN null mice ENTPD5, is found to be upregulated by AKT activation; this enzyme seems to mediate many of the observed cancer-related phenotypes associated with AKT activation., [RefSeq, PubMed]; Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10369669, PubMed:21074248). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose (PubMed:21074248). Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose (PubMed:21074248). Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (PubMed:21074248)., [UniProtKB, PubMed, PubMed]; Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1., [RefSeq, PubMed]; The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70214;Q544J4;Q8BR23;Q8CD29", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.1.5;3.1.3.1;3.9.1.1;3.6.1.-;3.6.5.-;3.6.1.6;3.6.1.16;3.6.1.53;3.6.1.15;3.6.1.42", "go_molecular_function": "GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:1990003 IDP phosphatase activity;GO:0036384 CDP phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006256 UDP catabolic process;GO:0006487 protein N-linked glycosylation;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0051084 'de novo' post-translational protein folding", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WUZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV03-1", "uniprot_id": "FA50A_MOUSE", "mass": 40252.0, "length": 339, "protein_name": "Protein FAM50A", "gene_name": "Fam50a", "organism": "Mouse", "refseq_name": "protein FAM50A", "refseq_ac": "NP_613073", "gene_names_uniprotkb": "Fam50a; D0HXS9928E; Xap5", "gene_names_refseq": "D0HXS9928E; Fam50a; XAP-5", "protein_names_uniprotkb": "Protein FAM50A; Protein XAP-5", "protein_names_refseq": "protein FAM50A; protein XAP-5", "tax_id": 10090, "disease": "Armfield syndrome (Disease Ontology:DOID:0050764)", "pathway": " (mmu:108160); (R-MMU-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10534398;28574578;34428180", "class_list": "", "function": "Fam50a might be a new positive regulator of ameloblast differentiation, increasing binding affinity of Runx2 to Ambn promoter by physically interacting with Runx2., [RefSeq, PubMed]; Probably involved in the regulation of pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D866", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006325 chromatin organization;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WV03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0R9-1", "uniprot_id": "FADS2_MOUSE", "mass": 52387.0, "length": 444, "protein_name": "Acyl-CoA 6-desaturase", "gene_name": "Fads2", "organism": "Mouse", "refseq_name": "acyl-CoA 6-desaturase", "refseq_ac": "NP_062673", "gene_names_uniprotkb": "Fads2; Fadsd2", "gene_names_refseq": "2900042M13Rik; Fads2a; Fads2; Fadsd2", "protein_names_uniprotkb": "Acyl-CoA 6-desaturase; 1.14.19.3; D6D; Delta(6) desaturase; Delta(6) fatty acid desaturase; Delta-6 desaturase; Fatty acid desaturase 2", "protein_names_refseq": "D6D; acyl-CoA 6-desaturase; delta(6) desaturase; delta(6) fatty acid desaturase", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); discrete subaortic stenosis (Disease Ontology:DOID:5804); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:56473); (R-MMU-2046105); (R-MMU-2046106)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11792729;17971455;18719641;21750661;22872234;34203471;34428180;38678785;38926633;39094710;9867867", "class_list": "", "function": "CXCR4 influences PUFA desaturation and oxidative stress injury in experimental prostatitis mice by activating Fads2 via PPARgamma., [RefSeq, PubMed]; Conjugated linoleic acid-induced fat loss was found to be dependent on delta6-desaturase activity., [RefSeq, PubMed]; FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer., [RefSeq, PubMed]; Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:9867867). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of hyperhomocysteinemia., [RefSeq, PubMed]; PPAR-alpha inhibits DHEA-induced ferroptosis in granulosa cells through upregulation of FADS2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.19.3", "go_molecular_function": "GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016213 acyl-CoA 6-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0016215 acyl-CoA desaturase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:1900409 positive regulation of cellular response to oxidative stress;GO:0002538 arachidonate metabolite production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z0R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z191-1", "uniprot_id": "EYA4_MOUSE", "mass": 66875.0, "length": 616, "protein_name": "Protein phosphatase EYA4", "gene_name": "Eya4", "organism": "Mouse", "refseq_name": "protein phosphatase EYA4 isoform 2", "refseq_ac": "NP_001334301", "gene_names_uniprotkb": "Eya4", "gene_names_refseq": "B130023L16Rik; Eya4", "protein_names_uniprotkb": "Protein phosphatase EYA4; 3.1.3.48; Eyes absent homolog 4", "protein_names_refseq": "eyes absent 4 homolog; eyes absent homolog 4; protein phosphatase EYA4 isoform 2; protein phosphatase EYA4", "tax_id": 10090, "disease": "dilated cardiomyopathy 1J (Disease Ontology:DOID:0110440); autosomal dominant nonsyndromic deafness 10 (Disease Ontology:DOID:0110542); sensorineural hearing loss (Disease Ontology:DOID:10003); otitis media (Disease Ontology:DOID:10754); dilated cardiomyopathy (Disease Ontology:DOID:12930); branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:14051); (R-MMU-5693565)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15492887;18219393;19561593;21750661;25428506;30084848;32782141;9887327", "class_list": "", "function": "Constructs of the homologous region ( Eya1HR and Eya4HR) interact with Six1 prey constructs, although no interaction with Dach1 prey was demonstrable, [RefSeq, PubMed]; Eya4(-/-) mice developed otitis media with effusion; anatomic studies revealed abnormal middle ear cavity and eustachian tube dysmorphology., [RefSeq, PubMed]; That Eyes absent 4 (EYA4), originally identified as a co-transcription factor, stimulates the expression of IFN-beta and CXCL10 in response to the undigested DNA of apoptotic cells, [RefSeq, PubMed]; Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q0VAV8", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.6.-.-;3.1.-.-;2.7.11.1;3.1.3.27;3.1.3.5;2.3.1.48;2.3.1.-;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045739 positive regulation of DNA repair;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z191-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1D1-1", "uniprot_id": "EIF3G_MOUSE", "mass": 35638.0, "length": 320, "protein_name": "Eukaryotic translation initiation factor 3 subunit G", "gene_name": "Eif3g", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit G", "refseq_ac": "NP_058572", "gene_names_uniprotkb": "Eif3g; Eif3p42; Eif3s4", "gene_names_refseq": "44kDa; D0Jmb4; Eif3g; Eif3s4; TU-189B2; eIF3-p44; p44", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit G; Eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 p42; eIF3 p44; eIF3g", "protein_names_refseq": "eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 p42; eIF3 p44; eiF3 delta; eukaryotic translation initiation factor 3 RNA-binding subunit; eukaryotic translation initiation factor 3 subunit 4; eukaryotic translation initiation factor 3 subunit G; eukaryotic translation initiation factor 3 subunit p42; eukaryotic translation initiation factor 3, subunit 4 (delta); eukaryotic translation initiation factor 3, subunit 4 (delta, 44 kDa); eukaryotic translation initiation factor 3, subunit 4 (delta, 44kD); translation initiation factor eIF3-p44", "tax_id": 10090, "disease": "", "pathway": " (mmu:53356); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16479539;17242355;17581632;18250455;19144319;21183079;25153642;25428507;25605945;26100019;26495903;28528544;34428180;35820727;37828378", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R079", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0016282 eukaryotic 43S preinitiation complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9Z1D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2D8-1", "uniprot_id": "MBD3_MOUSE", "mass": 32168.0, "length": 285, "protein_name": "Methyl-CpG-binding domain protein 3", "gene_name": "Mbd3", "organism": "Mouse", "refseq_name": "methyl-CpG-binding domain protein 3 isoform 2", "refseq_ac": "NP_001293072", "gene_names_uniprotkb": "Mbd3", "gene_names_refseq": "Mbd3", "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3", "protein_names_refseq": "methyl-CpG-binding domain protein 3 isoform 2; methyl-CpG-binding protein MBD3", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:17192); (R-MMU-3214815); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10441743;10444591;10471500;14610093;17289276;21183079;21750661;30228260;30327463;31219806;34592200;40773920;9774669", "class_list": "", "function": "A 1072 base pair fragment of the MBD3 promoter is sufficient to drive expression in cell lines and primary cultured neurons., [RefSeq, PubMed]; Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Does not bind methylated DNA by itself (PubMed:9774669). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of Mi-2 chromatin remodelling and histone deacetylation complex in Xenopus laevis oocytes, [RefSeq, PubMed]; Component of Nucleosome Remodelling and Histone Deacetylation (NuRD) co-repressor complex, [RefSeq, PubMed]; Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers., [RefSeq, PubMed]; This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q792D3;Q8CFJ1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z2D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T03-1", "uniprot_id": "MUC6_MOUSE", "mass": 300401.0, "length": 2850, "protein_name": "Mucin-6", "gene_name": "Muc6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Muc6", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-6; Gastric mucin-6; MUC-6; Secreted gel-forming mucin-6", "protein_names_refseq": "", "tax_id": 10090, "disease": "gastric ulcer (Disease Ontology:DOID:10808); pancreatic cancer (Disease Ontology:DOID:1793); mucinous adenocarcinoma (Disease Ontology:DOID:3030); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (R-MMU-913709); (R-MMU-977068)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12676567;14984930;21750661", "class_list": "", "function": "May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 2, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q80Z22", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80T03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Z19-1", "uniprot_id": "MUC2_MOUSE", "mass": 479290.0, "length": 4576, "protein_name": "Mucin-2", "gene_name": "Muc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Muc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-2; Colonic mucin; MCM; MUC-2; Secreted gel-forming mucin", "protein_names_refseq": "", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); pre-malignant neoplasm (Disease Ontology:DOID:0060071); colitis (Disease Ontology:DOID:0060180); mucositis (Disease Ontology:DOID:0080178); allergic conjunctivitis (Disease Ontology:DOID:11204); primary biliary cholangitis (Disease Ontology:DOID:12236); cystic fibrosis (Disease Ontology:DOID:1485); cystitis (Disease Ontology:DOID:1679); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841); mucinous adenocarcinoma (Disease Ontology:DOID:3030); ischemia (Disease Ontology:DOID:326); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); pneumonia (Disease Ontology:DOID:552); ulcerative colitis (Disease Ontology:DOID:8577); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11872843;14984930;18806221;19432394;30084848;33093110;9886986", "class_list": "", "function": "Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (PubMed:18806221, PubMed:19432394, PubMed:33093110). Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine (PubMed:18806221, PubMed:19432394, PubMed:33093110). MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange (PubMed:18806221, PubMed:19432394). Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells (By similarity). Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site (By similarity). MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells (By similarity). Mucin gels store antimicrobial molecules that participate in innate immunity (PubMed:18806221, PubMed:19432394). Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body (PubMed:33093110). Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon (PubMed:33093110). 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (PubMed:33093110)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 73, "predicted_n_glycosites": 33, "predicted_o_glycosites": 40, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 74, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WSG8;Q0P637;Q80Z17;Q8K0Q1;Q9CVG8;Q9Z2U5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:1903136 cuprous ion binding;GO:1903135 cupric ion binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0070701 mucus layer;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070702 inner mucus layer;GO:0070703 outer mucus layer", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80Z19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZM8-1", "uniprot_id": "MUC4_MOUSE", "mass": 368411.0, "length": 3470, "protein_name": "Mucin-4", "gene_name": "Muc4", "organism": "Mouse", "refseq_name": "mucin-4 precursor", "refseq_ac": "NP_536705", "gene_names_uniprotkb": "Muc4", "gene_names_refseq": "4933405I11Rik; Asgp; Muc4", "protein_names_uniprotkb": "Mucin-4; ASGP-1; ASGP-2; ASGP; Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein; MUC-4; Pancreatic adenocarcinoma mucin; Testis mucin", "protein_names_refseq": "ascites sialoglycoprotein; mucin 4, ASGP; mucin-4 precursor; pancreatic adenocarcinoma mucin; testis mucin", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); mucositis (Disease Ontology:DOID:0080178); Coronavirus infectious disease (Disease Ontology:DOID:0080599); otitis media (Disease Ontology:DOID:10754); allergic conjunctivitis (Disease Ontology:DOID:11204); corneal neovascularization (Disease Ontology:DOID:11382); pancreatic cancer (Disease Ontology:DOID:1793); mucinous adenocarcinoma (Disease Ontology:DOID:3030); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung carcinoma (Disease Ontology:DOID:3905); lung adenocarcinoma (Disease Ontology:DOID:3910); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:140474); (R-MMU-913709); (R-MMU-977068)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12084055;12107190;15672420;17553805;21750661;29237092;35255004;36624189;37604830", "class_list": "", "function": "As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels, [RefSeq, PubMed]; Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer., [RefSeq, PubMed]; Full coding sequence was cloned and mapped to chromosome 16, it's highest levels of expression are in trachea and intestinal tract, [RefSeq, PubMed]; MUC4 is regulated at the transcriptional level by CDX-1 and -2, HNF-1 alpha and -1 beta, FOXA1/A2, HNF-4 alpha and -4 gamma, and GATA-4, -5, and -6 factors in a cell-specific manner, [RefSeq, PubMed]; Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation., [UniProtKB, UniProtKB]; Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis., [RefSeq, PubMed]; Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface. A large 5' exon encodes at least 15 tandem repeats of 124-126 amino acids. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 262, "predicted_n_glycosites": 52, "predicted_o_glycosites": 210, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 13, "glyco_site_count": 265, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAA3;Q9ERB8;Q9QXG0;Q9WV36", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005176 ErbB-2 class receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex;GO:0031528 microvillus membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0007160 cell-matrix adhesion;GO:0001953 negative regulation of cell-matrix adhesion;GO:0010469 regulation of signaling receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8JZM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UWS6-1", "uniprot_id": "MYCOS_MOUSE", "mass": 15568.0, "length": 143, "protein_name": "Myocilin opposite strand protein", "gene_name": "Myocos", "organism": "Mouse", "refseq_name": "myocilin opposite strand protein", "refseq_ac": "NP_001171052", "gene_names_uniprotkb": "Myocos; 7420461P10Rik", "gene_names_refseq": "7420461P10Rik; Myocos", "protein_names_uniprotkb": "Myocilin opposite strand protein", "protein_names_refseq": "myocilin opposite strand protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100038657)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UWS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18155-1", "uniprot_id": "MTDC_MOUSE", "mass": 37863.0, "length": 350, "protein_name": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "gene_name": "Mthfd2", "organism": "Mouse", "refseq_name": "bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor", "refseq_ac": "NP_032664", "gene_names_uniprotkb": "Mthfd2; Nmdmc", "gene_names_refseq": "Mthfd2; NMDMC", "protein_names_uniprotkb": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "protein_names_refseq": "bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:17768); (R-MMU-196757)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "18250455;1843253;1999293;21750661;2647744;26495903;28011936;28935714;3487546;35820727;37450958;37828378;38407485", "class_list": "", "function": "Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency., [UniProtKB, UniProtKB]; Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species-mediated NF-kappaB Activation and Protects against Inflammatory Responses., [RefSeq, PubMed]; Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMN4", "ec_number_list": "1.5.1.5;3.5.4.9;1.5.1.15;6.3.4.3", "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0000287 magnesium ion binding;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0015943 formate biosynthetic process;GO:0006730 one-carbon metabolic process;GO:0006760 folic acid-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P18155-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BU40-1", "uniprot_id": "NAL4A_MOUSE", "mass": 112601.0, "length": 982, "protein_name": "NACHT, LRR and PYD domains-containing protein 4A", "gene_name": "Nlrp4a", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 4A", "refseq_ac": "NP_766484", "gene_names_uniprotkb": "Nlrp4a; Nalp4a", "gene_names_refseq": "E330021B02; E330028A19Rik; NALP4; Nalp-eta; Nalp-ita; Nalp4a; Nlrp4a", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 4A; NALP-ita", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 4A; NACHT, leucine rich repeat and PYD containing 4A; NACHT/LRR/pyrin domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:243880)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15317747;21750661", "class_list": "", "function": "May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050727 regulation of inflammatory response;GO:0070936 protein K48-linked ubiquitination;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BU40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XKE0-1", "uniprot_id": "MYPC2_MOUSE", "mass": 127352.0, "length": 1136, "protein_name": "Myosin-binding protein C, fast-type", "gene_name": "Mybpc2", "organism": "Mouse", "refseq_name": "myosin-binding protein C, fast-type", "refseq_ac": "NP_666301", "gene_names_uniprotkb": "Mybpc2", "gene_names_refseq": "Mybpc2", "protein_names_uniprotkb": "Myosin-binding protein C, fast-type; C-protein, skeletal muscle fast isoform; Fast MyBP-C", "protein_names_refseq": "fast MyBP-C; fast-type C-protein; myosin-binding protein C, fast-type", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:233199); (R-MMU-390522)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;25577193;31219806;36409445;37828378;38802450;39927985", "class_list": "", "function": "Fast and slow skeletal myosin binding protein-C and aging., [RefSeq, PubMed]; Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure. Publication Status: Online-Only, [RefSeq, PubMed]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C109;Q8K2V0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0032982 myosin filament;GO:0031430 M band", "go_biological_process": "GO:0006936 muscle contraction;GO:0007155 cell adhesion;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5XKE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JF5-1", "uniprot_id": "MVD1_MOUSE", "mass": 44072.0, "length": 401, "protein_name": "Diphosphomevalonate decarboxylase", "gene_name": "Mvd", "organism": "Mouse", "refseq_name": "diphosphomevalonate decarboxylase", "refseq_ac": "NP_619597", "gene_names_uniprotkb": "Mvd", "gene_names_refseq": "Mpd; Mvd", "protein_names_uniprotkb": "Diphosphomevalonate decarboxylase; 4.1.1.33; MDDase; Mevalonate (diphospho)decarboxylase; Mevalonate pyrophosphate decarboxylase", "protein_names_refseq": "MDDase; diphosphomevalonate decarboxylase; mevalonate pyrophosphate decarboxylase", "tax_id": 10090, "disease": "porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (mmu:192156); (R-MMU-446199); (R-MMU-9969896)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12646231;12736493;19224205;20173027;21750661;25428506;30084848;30779550;34203471;34428180", "class_list": "", "function": "Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis., [UniProtKB, UniProtKB]; Results identify mevalonate pyrophosphate decarboxylase (MPD) as a binding partner of mortalin-2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCD8;Q8BTM4;Q922D7", "ec_number_list": "4.1.1.33", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0030544 Hsp70 protein binding;GO:0004163 diphosphomevalonate decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99JF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q634-1", "uniprot_id": "MYO1E_MOUSE", "mass": 126818.0, "length": 1107, "protein_name": "Unconventional myosin-Ie", "gene_name": "Myo1e", "organism": "Mouse", "refseq_name": "unconventional myosin-Ie", "refseq_ac": "NP_851417", "gene_names_uniprotkb": "Myo1e; Myr3", "gene_names_refseq": "2310020N23Rik; 9130023P14Rik; Myo1e; myosin-1e; myr 3", "protein_names_uniprotkb": "Unconventional myosin-Ie; Unconventional myosin 1E", "protein_names_refseq": "molecular motor; unconventional myosin 1E; unconventional myosin-Ie", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis 6 (Disease Ontology:DOID:0111131)", "pathway": " (mmu:71602)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12486594;19005011;19144319;21750661;29187734;31219806;32916757;33470457;34428180;34887587;36210013", "class_list": "", "function": "LSP1-myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain (By similarity). Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated ve (By similarity)sicles. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity)., [UniProtKB, PubMed]; SH3P2 suppresses osteoclast differentiation through restricting membrane localization of myosin 1E., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80X36;Q91ZI4", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005912 adherens junction", "go_biological_process": "GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "E9Q634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQS3-1", "uniprot_id": "MYCBP_MOUSE", "mass": 11970.0, "length": 103, "protein_name": "c-Myc-binding protein", "gene_name": "Mycbp", "organism": "Mouse", "refseq_name": "C-Myc-binding protein", "refseq_ac": "NP_062634", "gene_names_uniprotkb": "Mycbp; Amy1", "gene_names_refseq": "5730488M09Rik; Amy-1; Mycbp", "protein_names_uniprotkb": "c-Myc-binding protein; AMY-1; Associate of Myc 1", "protein_names_refseq": "C-Myc-binding protein; associate of Myc 1; c-myc binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56309)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12223483;12620400;19066578;20119621;20660764;21750661;39853433", "class_list": "", "function": "Identified a novel AMY-1-binding protein, AAT-1, and determied its expression profiles, genes, and cellular localization; results showed that AAT-1 was specifically expressed in the testis throughout spermatogenesis and was also present in mature sperm, [RefSeq, PubMed]; L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc., [RefSeq, PubMed]; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity)., [UniProtKB]; The advantage of this system over the traditional retroviral infection is the ability to turn the genes on and off so that the kinetics of reprogramming and gene expression requirements can be analyzed in detail. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggested that hAECs can alter mouse ESC gene expression via epigenetic modification of c-Myc, providing a possible mechanism for the hAEC-induced maintenance of ESCs in an undifferentiated state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88308;Q8R048", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EQS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JS0-1", "uniprot_id": "NCMAP_MOUSE", "mass": 10846.0, "length": 100, "protein_name": "Noncompact myelin-associated protein", "gene_name": "Ncmap", "organism": "Mouse", "refseq_name": "noncompact myelin-associated protein isoform 1", "refseq_ac": "NP_001161970", "gene_names_uniprotkb": "Ncmap; A330049M08Rik", "gene_names_refseq": "A330049M08Rik; Mp11; Ncmap", "protein_names_uniprotkb": "Noncompact myelin-associated protein; MP11; Myelin protein of 11 kDa", "protein_names_refseq": "myelin protein of 11 kDa; noncompact myelin-associated protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230822)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18650334;21750661", "class_list": "", "function": "Plays a role in myelin formation., [UniProtKB]; This study identified an evolutionarily conserved novel component of myelin called Mp11. The Mp11 genomic locus contains multiple conserved Egr binding sites, and Mp11 induction is regulated by the expression of Egr2 and expression in peripheral nerve., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043220 Schmidt-Lanterman incisure;GO:0033270 paranode region of axon", "go_biological_process": "GO:0032290 peripheral nervous system myelin formation;GO:0031643 positive regulation of myelination;GO:0031641 regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99JS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ABU4-1", "uniprot_id": "MYOM3_MOUSE", "mass": 161778.0, "length": 1439, "protein_name": "Myomesin-3", "gene_name": "Myom3", "organism": "Mouse", "refseq_name": "myomesin-3", "refseq_ac": "NP_001078978", "gene_names_uniprotkb": "Myom3", "gene_names_refseq": "8430427K15Rik; Gm434; Myom3", "protein_names_uniprotkb": "Myomesin-3; Myomesin family member 3", "protein_names_refseq": "myomesin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:242702)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18177667;26060189;30016717", "class_list": "", "function": "MYOM3 fragments hold promise for minimally invasive assessment of experimental therapies for DMD and other neuromuscular disorders., [RefSeq, PubMed]; May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle., [UniProtKB]; Myomesin 3, a novel structural component of the M-band in striated muscle., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0031430 M band", "go_biological_process": "GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2ABU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBV4-1", "uniprot_id": "MXRA8_MOUSE", "mass": 49750.0, "length": 442, "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "Mxra8", "organism": "Mouse", "refseq_name": "matrix remodeling-associated protein 8 precursor", "refseq_ac": "NP_077225", "gene_names_uniprotkb": "Mxra8; Asp3; Dicam", "gene_names_refseq": "1200013A08Rik; 1700095D18Rik; Asp3; Dicam; Mxra8", "protein_names_uniprotkb": "Matrix remodeling-associated protein 8; Adipocyte-specific protein 3; DICAM; Dual Ig domain-containing cell adhesion molecule; Limitrin", "protein_names_refseq": "adipocyte-specific protein 3; dual Ig domain containing cell adhesion molecule; limitrin; matrix remodeling-associated protein 8 precursor; matrix-remodeling-associated protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:74761); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;14603461;18366072;21750661;22492581;29702220;30899004;31599954;34428180;36230938;37036079;37828378", "class_list": "", "function": "DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation. Publication Status: Online-Only, [RefSeq, PubMed]; New member of the transmembrane-type immunoglobulin superfamily and designated limitrin, localizing selectively to glia limitans in mouse brain, [RefSeq, PubMed]; Results indicate that DICAM, a novel dual Ig domain containing adhesion molecule, mediates cell adhesion via alphavbeta3 integrin., [RefSeq, PubMed]; Role of MXRA8 in Ross River Virus Disease Pathogenesis., [RefSeq, PubMed]; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q76M97;Q920S7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0060857 establishment of glial blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9DBV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCM7-1", "uniprot_id": "NACC2_MOUSE", "mass": 63219.0, "length": 586, "protein_name": "Nucleus accumbens-associated protein 2", "gene_name": "Nacc2", "organism": "Mouse", "refseq_name": "nucleus accumbens-associated protein 2", "refseq_ac": "NP_001032175", "gene_names_uniprotkb": "Nacc2; Btbd14a", "gene_names_refseq": "0610020I02Rik; Btbd14a; C030048H19Rik; Nacc2", "protein_names_uniprotkb": "Nucleus accumbens-associated protein 2; BTB/POZ domain-containing protein 14A; NAC-2", "protein_names_refseq": "BTB (POZ) domain containing 14A; BTB/POZ domain-containing protein 14A; NAC-2; nucleus accumbens-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67991)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;34428180", "class_list": "", "function": "Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZD3;Q8VDF8", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0044877 protein-containing complex binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AVR2-1", "uniprot_id": "MROH7_MOUSE", "mass": 141710.0, "length": 1279, "protein_name": "Maestro heat-like repeat-containing protein family member 7", "gene_name": "Mroh7", "organism": "Mouse", "refseq_name": "maestro heat-like repeat-containing protein family member 7", "refseq_ac": "NP_001119959", "gene_names_uniprotkb": "Mroh7; Gm1027; Heatr8", "gene_names_refseq": "Gm1027; Heatr8; Mroh7", "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 7; HEAT repeat-containing protein 8", "protein_names_refseq": "HEAT repeat-containing protein 8; maestro heat-like repeat-containing protein family member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:381538)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AVR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10166-1", "uniprot_id": "MYCL_MOUSE", "mass": 40848.0, "length": 368, "protein_name": "Protein L-Myc", "gene_name": "Mycl", "organism": "Mouse", "refseq_name": "protein L-Myc isoform 2", "refseq_ac": "NP_001290050", "gene_names_uniprotkb": "Mycl; Lmyc1; Mycl1", "gene_names_refseq": "L-myc; Lmyc-1; Lmyc1; Mycl1; Mycl; bHLHe38", "protein_names_uniprotkb": "Protein L-Myc", "protein_names_refseq": "L-myc-1 proto-oncogene protein; lung carcinoma myc related oncogene 1; protein L-Myc isoform 2; protein L-Myc-1; v-myc avian myelocytomatosis viral oncogene lung carcinoma derived; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived; v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived", "tax_id": 10090, "disease": "", "pathway": " (mmu:16918)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;2828024;34428180;35820727", "class_list": "", "function": "This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWI7", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045607 regulation of inner ear auditory receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5X0G2-1", "uniprot_id": "MUP17_MOUSE", "mass": 20638.0, "length": 180, "protein_name": "Major urinary protein 17", "gene_name": "Mup17", "organism": "Mouse", "refseq_name": "major urinary protein 17 precursor", "refseq_ac": "NP_001186935", "gene_names_uniprotkb": "Mup17; Mup15", "gene_names_refseq": "100039206; Gm12557; MUP 17; Mup17", "protein_names_uniprotkb": "Major urinary protein 17; MUP 17", "protein_names_refseq": "major urinary protein 17 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039206)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18507838;18815613;34428180", "class_list": "", "function": "Major urinary proteins (Mups) bind pheromones, thus stabilize them and allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B5X0G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W39-1", "uniprot_id": "NCOA5_MOUSE", "mass": 65319.0, "length": 579, "protein_name": "Nuclear receptor coactivator 5", "gene_name": "Ncoa5", "organism": "Mouse", "refseq_name": "nuclear receptor coactivator 5", "refseq_ac": "NP_659141", "gene_names_uniprotkb": "Ncoa5", "gene_names_refseq": "CIA; Ncoa5", "protein_names_uniprotkb": "Nuclear receptor coactivator 5; CIA; Coactivator independent of AF-2; NCoA-5", "protein_names_refseq": "NCoA-5; coactivator independent of AF-2; nuclear receptor coactivator 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:228869)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11113208;17242355;21183079;21750661;22517741;22645316;24268775;25428506;25605945;32203160;32848054;34428180;34678516;36852467;37734594;40021952;40885482;40997131", "class_list": "", "function": "NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma., [RefSeq, PubMed]; NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin., [RefSeq, PubMed]; Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2A5L2", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton;GO:0005634 nucleus", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006351 DNA-templated transcription;GO:0042593 glucose homeostasis;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q91W39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ08-1", "uniprot_id": "NAGK_MOUSE", "mass": 37268.0, "length": 343, "protein_name": "N-acetyl-D-glucosamine kinase", "gene_name": "Nagk", "organism": "Mouse", "refseq_name": "N-acetyl-D-glucosamine kinase isoform 1", "refseq_ac": "NP_062415", "gene_names_uniprotkb": "Nagk; Gnk", "gene_names_refseq": "Gnk; Nagk", "protein_names_uniprotkb": "N-acetyl-D-glucosamine kinase; 2.7.1.-; 2.7.1.59; 2.7.1.60; GlcNAc kinase; Muramyl dipeptide kinase; N-acetyl-D-mannosamine kinase; N-acetylglucosamine kinase", "protein_names_refseq": "GlcNAc kinase; N-acetyl-D-glucosamine kinase isoform 1; N-acetyl-D-glucosamine kinase; N-acetyl-D-mannosamine kinase; muramyl dipeptide kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56174); (R-MMU-446210)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10824116;21183079;21750661;22692205;24722415;32796833;34428180;36002575", "class_list": "glycogene", "function": "Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:10824116). Also has N-acetylmannosamine (ManNAc) kinase activity (PubMed:10824116). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575)., [UniProtKB, PubMed, PubMed, PubMed]; N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation., [RefSeq, PubMed]; Small domain, and not kinase activity, promotes dendritogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.60;2.7.1.59;2.7.1.-", "go_molecular_function": "GO:0009384 N-acylmannosamine kinase activity;GO:0005524 ATP binding;GO:0045127 N-acetylglucosamine kinase activity;GO:0160047 muramyl dipeptide kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0097039 protein linear polyubiquitination;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0006046 N-acetylglucosamine catabolic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QZ08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X97-1", "uniprot_id": "NCALD_MOUSE", "mass": 22245.0, "length": 193, "protein_name": "Neurocalcin-delta", "gene_name": "Ncald", "organism": "Mouse", "refseq_name": "neurocalcin-delta", "refseq_ac": "NP_001164337", "gene_names_uniprotkb": "Ncald; D15Ertd412e", "gene_names_refseq": "D030020D09Rik; D15Ertd412e; Ncald", "protein_names_uniprotkb": "Neurocalcin-delta", "protein_names_refseq": "neurocalcin-delta", "tax_id": 10090, "disease": "", "pathway": " (mmu:52589); (R-MMU-451308)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16101019;17548529;21750661", "class_list": "", "function": "According to their distribution in the olfactory bulb, neurocalcin-immunoreactive interneurons could reflect a sexually dimorphic regulation of specific odorants., [RefSeq, PubMed]; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Neurocalcin-containing DRG neurons include all proprioceptive, and a subset of mechanoreceptive and proprioceptive. Furthermore, NT-3 is involved in the maturation of motor end-plates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJS9;Q8BZN9", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding;GO:0030276 clathrin binding;GO:0015631 tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0009966 regulation of signal transduction;GO:0003073 regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91X97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQK5-1", "uniprot_id": "MVP_MOUSE", "mass": 95924.0, "length": 861, "protein_name": "Major vault protein", "gene_name": "Mvp", "organism": "Mouse", "refseq_name": "major vault protein", "refseq_ac": "NP_542369", "gene_names_uniprotkb": "Mvp", "gene_names_refseq": "2310009M24Rik; LRP; Mvp; VAULT1", "protein_names_uniprotkb": "Major vault protein; MVP", "protein_names_refseq": "major vault protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78388); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11149928;15093136;16479539;19779459;21750661;25605945;26495903;26740625;28011936;30084848;31219806;32152506;34428180;36064721;37453647;37968726;39069011", "class_list": "", "function": "Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein. Publication Status: Online-Only, [RefSeq, PubMed]; Major vault protein directly enhances adaptive immunity induced by Influenza A virus or indirectly through innate immunity., [RefSeq, PubMed]; Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases., [UniProtKB, UniProtKB]; Structural component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity). Oligomerizes to form a cage-like vault complex, which can house several minor vault components including PARP4 (By similarity). Vaults may play a role in nucleo-cytoplasmic transport (By similarity). Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK (By similarity). Down-regulates SRC activity and signaling through MAP kinases (By similarity)., [UniProtKB, UniProtKB]; These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q922X6", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0072376 protein activation cascade;GO:0038127 ERBB signaling pathway;GO:0008283 cell population proliferation;GO:0035556 intracellular signal transduction;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9EQK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZR2-1", "uniprot_id": "NALD2_MOUSE", "mass": 82801.0, "length": 740, "protein_name": "N-acetylated-alpha-linked acidic dipeptidase 2", "gene_name": "Naalad2", "organism": "Mouse", "refseq_name": "N-acetylated-alpha-linked acidic dipeptidase 2 isoform b", "refseq_ac": "NP_082555", "gene_names_uniprotkb": "Naalad2", "gene_names_refseq": "2700022G20Rik; D9Ertd285e; Folh1b; GCP3; GCPIII; NAADALASE2; NAALADASE2; Naalad2", "protein_names_uniprotkb": "N-acetylated-alpha-linked acidic dipeptidase 2; 3.4.17.21; GCPIII; Glutamate carboxypeptidase III; N-acetylaspartylglutamate peptidase II; N-acetylated-alpha-linked acidic dipeptidase II; NAAG-peptidase II; NAALADase II", "protein_names_refseq": "N-acetylaspartylglutamate peptidase II; N-acetylated-alpha-linked acidic dipeptidase 2 isoform b; N-acetylated-alpha-linked acidic dipeptidase II; NAAG-peptidase II; NAALADase II; glutamate carboxypeptidase III", "tax_id": 10090, "disease": "", "pathway": " (mmu:72560); (R-MMU-8963693)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15086519;19656770;20173027;21750661;21908619;25428506;28011936;30899004;37349952;37828378", "class_list": "", "function": "Analysis of GCP2 and GCP3; beta-citrylglutamate hydrolase is glutamate carboxypeptidase 3, [RefSeq, PubMed]; Cloning and characterization of a mouse enzyme that is homologous to an enzyme identified in a human lung carcinoma., [RefSeq, PubMed]; Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury., [RefSeq, PubMed]; Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q80YF8", "ec_number_list": "3.4.17.21", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity;GO:0008233 peptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9CZR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBB4-1", "uniprot_id": "NAA16_MOUSE", "mass": 101284.0, "length": 864, "protein_name": "N-alpha-acetyltransferase 16, NatA auxiliary subunit", "gene_name": "Naa16", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 16, NatA auxiliary subunit", "refseq_ac": "NP_080108", "gene_names_uniprotkb": "Naa16; Narg1l; Nat2", "gene_names_refseq": "1300019C06Rik; Naa16; Narg1l", "protein_names_uniprotkb": "N-alpha-acetyltransferase 16, NatA auxiliary subunit; NARG1-like protein; NMDA receptor-regulated 1-like protein", "protein_names_refseq": "N-alpha-acetyltransferase 16, NatA auxiliary subunit; NARG1-like protein; NMDA receptor-regulated 1-like protein; Nalpha acetyltransferase 16", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:66897)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12888564;21750661;22872234;25428506;30084848;31219806;35820727", "class_list": "", "function": "Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7V2", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031415 NatA complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0050821 protein stabilization;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K224-1", "uniprot_id": "NAT10_MOUSE", "mass": 115419.0, "length": 1024, "protein_name": "RNA cytidine acetyltransferase", "gene_name": "Nat10", "organism": "Mouse", "refseq_name": "RNA cytidine acetyltransferase isoform 1", "refseq_ac": "NP_694766", "gene_names_uniprotkb": "Nat10; Kiaa1709", "gene_names_refseq": "Nat10", "protein_names_uniprotkb": "RNA cytidine acetyltransferase; 18S rRNA cytosine acetyltransferase; 2.3.1.-; N-acetyltransferase 10", "protein_names_refseq": "18S rRNA cytosine acetyltransferase; RNA cytidine acetyltransferase isoform 1; RNA cytidine acetyltransferase; novel putative ATPase domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:98956)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;29703891;31219806;34428180;34887587;35820727;36210013", "class_list": "", "function": "RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs. Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation. mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency. Mediates the formation of ac4C at position 1842 in 18S rRNA (By similarity). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (By similarity). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. The relevance of the protein lysine acetyltransferase activity is however unsure in vivo. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE04;Q6ZPJ7;Q80VD3;Q8BW78", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0051392 tRNA cytidine N4-acetyltransferase activity;GO:1990883 18S rRNA cytidine N-acetyltransferase activity;GO:0005524 ATP binding;GO:0070182 DNA polymerase binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030496 midbody;GO:0005697 telomerase holoenzyme complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0051391 tRNA acetylation;GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA;GO:0006417 regulation of translation;GO:0032211 negative regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K224-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UMQ8-1", "uniprot_id": "NAF1_MOUSE", "mass": 53246.0, "length": 489, "protein_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "gene_name": "Naf1", "organism": "Mouse", "refseq_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "refseq_ac": "NP_001157036", "gene_names_uniprotkb": "Naf1", "gene_names_refseq": "Gm174; Naf1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "protein_names_refseq": "H/ACA ribonucleoprotein complex non-core subunit NAF1; nuclear assembly factor 1 homolog", "tax_id": 10090, "disease": "melanoma (Disease Ontology:DOID:1909)", "pathway": " (mmu:234344)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;21183079;21750661;27510903;34428180", "class_list": "", "function": "RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2W2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0042254 ribosome biogenesis;GO:1904358 positive regulation of telomere maintenance via telomere lengthening;GO:1905323 telomerase holoenzyme complex assembly;GO:0090669 telomerase RNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UMQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHQ8-1", "uniprot_id": "NAA35_MOUSE", "mass": 83306.0, "length": 725, "protein_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "gene_name": "Naa35", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1", "refseq_ac": "NP_084429", "gene_names_uniprotkb": "Naa35; Egap; Mak10", "gene_names_refseq": "A330021G12Rik; A330027C19Rik; C030004C14Rik; Mak10; Naa35", "protein_names_uniprotkb": "N-alpha-acetyltransferase 35, NatC auxiliary subunit; Embryonic growth-associated protein; Protein MAK10 homolog", "protein_names_refseq": "MAK10 homolog, amino-acid N-acetyltransferase subunit; N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1; Nalpha acetyltransferase 35; embryonic growth-associated protein; protein MAK10 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78689)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16484612;21750661;25428506;25605945;34428180", "class_list": "", "function": "Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:16484612). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (By similarity). Involved in regulation of apoptosis and proliferation of smooth muscle cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05CD3;Q8BYJ9;Q8K3H2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031417 NatC complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0048659 smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PHQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70248-1", "uniprot_id": "MYO1F_MOUSE", "mass": 125947.0, "length": 1099, "protein_name": "Unconventional myosin-If", "gene_name": "Myo1f", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Myo1f", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-If", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:17916)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19144319;21750661;26740625;34428180;36210013;9119401", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007162 negative regulation of cell adhesion;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70354-1", "uniprot_id": "MSX3_MOUSE", "mass": 21971.0, "length": 204, "protein_name": "Homeobox protein MSX-3", "gene_name": "Msx3", "organism": "Mouse", "refseq_name": "homeobox protein MSX-3 isoform 1", "refseq_ac": "NP_034966", "gene_names_uniprotkb": "Msx3; Msx-3", "gene_names_refseq": "Msx3", "protein_names_uniprotkb": "Homeobox protein MSX-3", "protein_names_refseq": "homeo box, msh-like 3; homeobox protein MSX-3 isoform 1; homeobox, msh-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:17703)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10215616;11115394;1673109;21750661;8861099;8887328", "class_list": "", "function": "Acts as a potent transcriptional repressor of MSX1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70246;Q03360;Q80W10", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0035034 histone acetyltransferase regulator activity;GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70354-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88329-1", "uniprot_id": "MYO1A_MOUSE", "mass": 118695.0, "length": 1043, "protein_name": "Unconventional myosin-Ia", "gene_name": "Myo1a", "organism": "Mouse", "refseq_name": "unconventional myosin-Ia", "refseq_ac": "NP_001074688", "gene_names_uniprotkb": "Myo1a; Bbmi; Myhl", "gene_names_refseq": "BBM-I; Myhl; Myo1a", "protein_names_uniprotkb": "Unconventional myosin-Ia; BBM-I; BBMI; Brush border myosin I; MIHC; Myosin I heavy chain", "protein_names_refseq": "BBMI; MIHC; brush border myosin 1; brush border myosin I; myosin I heavy chain; myosin, heavy polypeptide-like (110kD); myosin-Ia; unconventional myosin-Ia", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:432516)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11739797;15758024;22510086;26286357;30059200;30084848;34428180;38710336;9933937", "class_list": "", "function": "Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes, [RefSeq, PubMed]; Gut microbiota promotes pain chronicity in Myosin1A deficient male mice., [RefSeq, PubMed]; Involved in directing the movement of organelles along actin filaments., [UniProtKB]; Myo1a and Myo6 play essential roles in response to intestinal mucosal injury, [RefSeq, PubMed]; The data indicates that Myo1a is an important regulator of CFTR traffic and anion transport in the brush border membrane of villus enterocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RW65", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0030033 microvillus assembly;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032880 regulation of protein localization;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02762-1", "uniprot_id": "MUP6_MOUSE", "mass": 20649.0, "length": 180, "protein_name": "Major urinary protein 6", "gene_name": "Mup19; Mup6", "organism": "Mouse", "refseq_name": "major urinary protein 16 precursor", "refseq_ac": "NP_001186865", "gene_names_uniprotkb": "Mup19; Mup6", "gene_names_refseq": "100039177; Mup16; Mup6", "protein_names_uniprotkb": "Major urinary protein 6; Alpha-2U-globulin; Group 1, BS6; MUP 6", "protein_names_refseq": "Alpha-2U-globulin; Group 1, BS6; MUP 6; Major urinary protein 6; major urinary protein 16 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100038948); (mmu:100039177); (mmu:100189605)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11316880;1279439;14871097;21750661;2824995;3004935;31044023;3858875;6329733;7107707;7937138;8065364", "class_list": "", "function": "Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70119;Q78EF5;Q91V46", "ec_number_list": "", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005576 extracellular region", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P02762-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03966-1", "uniprot_id": "MYCN_MOUSE", "mass": 49572.0, "length": 462, "protein_name": "N-myc proto-oncogene protein", "gene_name": "Mycn", "organism": "Mouse", "refseq_name": "N-myc proto-oncogene protein", "refseq_ac": "NP_032735", "gene_names_uniprotkb": "Mycn; Nmyc1; Nmyc", "gene_names_refseq": "Mycn; N-myc; Nmyc-1; Nmyc1; Nmyc; bHLHe37; c-nmyc", "protein_names_uniprotkb": "N-myc proto-oncogene protein", "protein_names_refseq": "N-myc proto-oncogene protein; neuroblastoma myc-related oncogene 1; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived", "tax_id": 10090, "disease": "Feingold syndrome (Disease Ontology:DOID:0060464); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18109)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "21698133;24391509;25428506;2555695;3015591;30573562;31920463;3287334;3513190;36852467;37710961;38297207;38336749;39402275;8521822", "class_list": "", "function": "Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/beta-catenin cascade. Publication Status: Online-Only, [RefSeq, PubMed]; Positively regulates the transcription of MYCNOS in neuroblastoma cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61978", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0019900 kinase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0071943 Myc-Max complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P03966-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04938-1", "uniprot_id": "MUP11_MOUSE", "mass": 20763.0, "length": 181, "protein_name": "Major urinary protein 11", "gene_name": "Mup11", "organism": "Mouse", "refseq_name": "major urinary protein 11 precursor", "refseq_ac": "NP_001157998", "gene_names_uniprotkb": "Mup11; Mup9", "gene_names_refseq": "Gm12549; Mup11; Mup16; Mup18", "protein_names_uniprotkb": "Major urinary protein 11", "protein_names_refseq": "Major urinary protein 18; major urinary protein 11 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039028); (mmu:100048884)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18815613;25279835;3004936;34428180", "class_list": "", "function": "Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (Probable). Binds the pheromone analog 2-sec-butyl-4,5-dihydrothiazole (SBT) in vitro (PubMed:25279835)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071394 cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04938-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04939-1", "uniprot_id": "MUP3_MOUSE", "mass": 21465.0, "length": 184, "protein_name": "Major urinary protein 3", "gene_name": "Mup3", "organism": "Mouse", "refseq_name": "major urinary protein 3 precursor", "refseq_ac": "NP_001034633", "gene_names_uniprotkb": "Mup3", "gene_names_refseq": "MUP15; MUPIII; Mup-3; Mup25; Mup3", "protein_names_uniprotkb": "Major urinary protein 3; MUP 3; Non-group 1/group 2 MUP15", "protein_names_refseq": "MUP 3; alpha-2u-globulin III; major urinary protein 25; major urinary protein 3 precursor; non-group 1/group 2 MUP15", "tax_id": 10090, "disease": "", "pathway": " (mmu:17842)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16944957;3004936;34428180;3600652", "class_list": "", "function": "Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97897;Q8VCG6", "ec_number_list": "", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04939-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11588-1", "uniprot_id": "MUP1_MOUSE", "mass": 20648.0, "length": 180, "protein_name": "Major urinary protein 1", "gene_name": "Mup1", "organism": "Mouse", "refseq_name": "major urinary protein 12 precursor", "refseq_ac": "NP_001186924", "gene_names_uniprotkb": "Mup1", "gene_names_refseq": "100039054; Gm2024; Mup12; Mup1", "protein_names_uniprotkb": "Major urinary protein 1; MUP 1", "protein_names_refseq": "MUP 1; Major urinary protein 1; major urinary protein 12 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039054); (mmu:17840)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16104761;21750661;2888770;3600652", "class_list": "", "function": "Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61921", "ec_number_list": "", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005186 pheromone activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005576 extracellular region", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0071240 cellular response to food;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11588-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11591-1", "uniprot_id": "MUP5_MOUSE", "mass": 20933.0, "length": 180, "protein_name": "Major urinary protein 5", "gene_name": "Mup5", "organism": "Mouse", "refseq_name": "major urinary protein 5 precursor", "refseq_ac": "NP_032675", "gene_names_uniprotkb": "Mup5; Mup18", "gene_names_refseq": "Mup18; Mup5", "protein_names_uniprotkb": "Major urinary protein 5", "protein_names_refseq": "MUP 5; Mup V; major urinary protein 18; major urinary protein 5 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17844)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18815613;23446533;3600652", "class_list": "", "function": "Gene-expression-inhibiting histone deacetylation (H3K9) occurred in the region of the Mup5 gene in response to diet restriction. Publication Status: Online-Only, [RefSeq, PubMed]; Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSZ7;B5TE77", "ec_number_list": "", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11591-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13542-1", "uniprot_id": "MYH8_MOUSE", "mass": 222708.0, "length": 1937, "protein_name": "Myosin-8", "gene_name": "Myh8", "organism": "Mouse", "refseq_name": "myosin-8", "refseq_ac": "NP_796343", "gene_names_uniprotkb": "Myh8; Myhsp", "gene_names_refseq": "4832426G23Rik; MHCp; MyHC-pn; Myh8; Myhs-p; Myhsp", "protein_names_uniprotkb": "Myosin-8; MyHC-perinatal; Myosin heavy chain 8; Myosin heavy chain, skeletal muscle, perinatal", "protein_names_refseq": "Beta-MHC antisense; myHC-perinatal; myosin heavy chain 8; myosin heavy chain, skeletal muscle, perinatal; myosin-8", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 7 (Disease Ontology:DOID:0111603); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); disease of cellular proliferation (Disease Ontology:DOID:14566); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:17885); (R-MMU-390522)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "37453647;3864153;39927985", "class_list": "", "function": "Muscle contraction., [UniProtKB]; This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SX36", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016459 myosin complex;GO:0016460 myosin II complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13542-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15375-1", "uniprot_id": "MYF6_MOUSE", "mass": 26987.0, "length": 242, "protein_name": "Myogenic factor 6", "gene_name": "Myf6", "organism": "Mouse", "refseq_name": "myogenic factor 6", "refseq_ac": "NP_032683", "gene_names_uniprotkb": "Myf6; Mrf4; Myf-6", "gene_names_refseq": "MRF4; Myf6; bHLHc4; herculin", "protein_names_uniprotkb": "Myogenic factor 6; Herculin; Muscle-specific regulatory factor 4; Myf-6", "protein_names_refseq": "muscle-specific regulatory factor 4; myogenic factor 6", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congenital structural myopathy (Disease Ontology:DOID:422)", "pathway": " (mmu:17878); (R-MMU-525793)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2045411;2300571", "class_list": "", "function": "Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0072686 mitotic spindle", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21271-1", "uniprot_id": "MYO5B_MOUSE", "mass": 210570.0, "length": 1818, "protein_name": "Unconventional myosin-Vb", "gene_name": "Myo5b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Myo5b; Kiaa1119", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-Vb", "protein_names_refseq": "", "tax_id": 10090, "disease": "microvillus inclusion disease (Disease Ontology:DOID:0060775); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:17919); (R-MMU-432040)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;2236059;25428506;29880681;30084848;30779550;34203471;34428180", "class_list": "", "function": "May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148A3;Q69ZR6;Q811F6;Q91X59", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045179 apical cortex;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005903 brush border", "go_biological_process": "GO:0036466 synaptic vesicle recycling via endosome;GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P21271-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24699-1", "uniprot_id": "MYF5_MOUSE", "mass": 28229.0, "length": 255, "protein_name": "Myogenic factor 5", "gene_name": "Myf5", "organism": "Mouse", "refseq_name": "myogenic factor 5", "refseq_ac": "NP_032682", "gene_names_uniprotkb": "Myf5; Myf-5", "gene_names_refseq": "B130010J22Rik; Myf-5; Myf5; bHLHc2", "protein_names_uniprotkb": "Myogenic factor 5; Myf-5", "protein_names_refseq": "myogenic factor 5; myogenic regulatory factor MYF-5", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17)", "pathway": " (mmu:17877); (R-MMU-525793)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1741288;21798092", "class_list": "", "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q543W7", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030198 extracellular matrix organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P24699-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28666-1", "uniprot_id": "MUG2_MOUSE", "mass": 162382.0, "length": 1451, "protein_name": "Murinoglobulin-2", "gene_name": "Mug2", "organism": "Mouse", "refseq_name": "murinoglobulin-2 precursor", "refseq_ac": "NP_032672", "gene_names_uniprotkb": "Mug2; Mug-2", "gene_names_refseq": "Cpamd8; Mug2", "protein_names_uniprotkb": "Murinoglobulin-2; MuG2", "protein_names_refseq": "C3 and PZP-like, alpha-2-macroglobulin domain containing 8; murinoglobulin-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17837)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;1840592;33725478;34428180;35984892", "class_list": "", "function": "A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28666-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60202-1", "uniprot_id": "MYPR_MOUSE", "mass": 30077.0, "length": 277, "protein_name": "Myelin proteolipid protein", "gene_name": "Plp1", "organism": "Mouse", "refseq_name": "myelin proteolipid protein isoform 2", "refseq_ac": "NP_001277490", "gene_names_uniprotkb": "Plp1; Plp", "gene_names_refseq": "DM20; Plp1; Plp; jimpy; jp; msd; rsh", "protein_names_uniprotkb": "Myelin proteolipid protein; Lipophilin; PLP", "protein_names_refseq": "lipophilin; myelin proteolipid protein isoform 2; myelin proteolipid protein; myelin synthesis deficiency; rump shaker", "tax_id": 10090, "disease": "hereditary spastic paraplegia 2 (Disease Ontology:DOID:0110773); intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); Pelizaeus-Merzbacher disease (Disease Ontology:DOID:3210)", "pathway": " (mmu:18823)", "pathway_count": 1, "publication_count": 74, "publication_id_list": "10092787;10190894;10229114;10623809;10684863;10954534;11102634;11254738;11306603;11359852;11457884;11593032;11694316;11937578;12133288;1377711;1380672;14978089;15098030;15240669;15634913;15735651;15927270;16054237;1688931;1716908;1719089;17376826;17465017;17629299;17634366;18354164;18490779;19362139;19949067;20149931;20483764;20933475;20965577;21696712;21949026;22319015;22645316;2273404;2432393;2441390;2442307;2444462;2449535;2451027;25428506;28495132;30084848;32532836;33300544;3466187;3469678;40885482;7540658;7686583;8609422;8666934;8822278;8892079;9091578;9130268;9256473;9334726;9357441;9394783;9544235;9565365;9574529;9589386", "class_list": "", "function": "This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P04400;P06905;Q9WUS9", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0034683 integrin alphav-beta3 complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0022010 central nervous system myelination;GO:0030335 positive regulation of cell migration;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 7.8, "record_id": "P60202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70402-1", "uniprot_id": "MYBPH_MOUSE", "mass": 52641.0, "length": 483, "protein_name": "Myosin-binding protein H", "gene_name": "Mybph", "organism": "Mouse", "refseq_name": "myosin-binding protein H", "refseq_ac": "NP_058029", "gene_names_uniprotkb": "Mybph", "gene_names_refseq": "MyBP-H; Mybph", "protein_names_uniprotkb": "Myosin-binding protein H; H-protein; MyBP-H", "protein_names_refseq": "H-protein; myosin-binding protein H", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:53311)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "28778945;30016717;30059200;39927985", "class_list": "", "function": "Binds to myosin; probably involved in interaction with thick myofilaments in the A-band., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKH7", "ec_number_list": "", "go_molecular_function": "GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0032982 myosin filament;GO:0031430 M band", "go_biological_process": "GO:0007155 cell adhesion;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70402-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3KNK3-1", "uniprot_id": "NB5R2_MOUSE", "mass": 31360.0, "length": 276, "protein_name": "NADH-cytochrome b5 reductase 2", "gene_name": "Cyb5r2", "organism": "Mouse", "refseq_name": "NADH-cytochrome b5 reductase 2 isoform 1", "refseq_ac": "NP_001192156", "gene_names_uniprotkb": "Cyb5r2", "gene_names_refseq": "Cyb5r2; D630003K02Rik; b5R.2", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 2; 1.6.2.2; b5R.2", "protein_names_refseq": "NADH-cytochrome b5 reductase 2 isoform 1; NADH-cytochrome b5 reductase 2; cytochrome b5 reductase b5R.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320635); (R-MMU-1237044)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGG1;Q8BUG7", "ec_number_list": "1.6.2.2", "go_molecular_function": "GO:0071949 FAD binding;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3KNK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UIZ8-1", "uniprot_id": "MYLK3_MOUSE", "mass": 86372.0, "length": 795, "protein_name": "Myosin light chain kinase 3", "gene_name": "Mylk3", "organism": "Mouse", "refseq_name": "myosin light chain kinase 3 isoform 2", "refseq_ac": "NP_001284541", "gene_names_uniprotkb": "Mylk3", "gene_names_refseq": "D830007F02Rik; MLCK; Mylk3", "protein_names_uniprotkb": "Myosin light chain kinase 3; 2.7.11.18; Cardiac MLCK; Cardiac MyBP-C-associated Ca/CaM kinase", "protein_names_refseq": "cardiac MLCK; cardiac-MyBP-C-associated Ca/CaM kinase; cardiac-specific myosin light chain kinase; myosin light chain kinase 3 isoform 2; putative myosin light chain kinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:213435)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15467390;15680356;15988034;16299103;16672772;17885681;18202317;21183079;21750661;30084848;32213617;34106787;34428180;37128901;37507081", "class_list": "", "function": "A temporal Ca(2+) desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKbeta/PP2A pathways., [RefSeq, PubMed]; Inhibiting MLCK increases the number of apoptotic cells and retards the growth of mammary cancer cells in mice., [RefSeq, PubMed]; Kinase that phosphorylates MYL2 in vitro (PubMed:17885681, PubMed:18202317). Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; MLCK is involved in egg polarity because inhibitors prevent sperm chromatin-induced cortical reorganization., [RefSeq, PubMed]; MLCK may be a regulatory target of Ca(2+)/calmodulin and may play an important role in insulin-stimulated glucose transport in adipocytes., [RefSeq, PubMed]; Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. Publication Status: Online-Only, [RefSeq, PubMed]; Myosin light chain phosphorylation by the dedicated skeletal muscle Ca(2+)/calmodulin-dependent MLCK is a primary biochemical mechanism for tension potentiation due to repetitive stimulation in fast-twitch skeletal muscle., [RefSeq, PubMed]; Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin., [RefSeq, PubMed]; Ubiquitously expressed smooth muscle MLCK activity in MLCK null mice may be sufficient, but is not necessary for cytokinesis and early morphogenesis; other Ca2+-dependent kinases can phosphorylate myosin light-chain (20) and induce contraction in embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0LY41;Q3V3V0;Q8BWD1", "ec_number_list": "2.7.11.18", "go_molecular_function": "GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0055003 cardiac myofibril assembly;GO:1905075 positive regulation of tight junction disassembly;GO:0045214 sarcomere organization;GO:0071347 cellular response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3UIZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UR85-1", "uniprot_id": "MYRF_MOUSE", "mass": 123288.0, "length": 1138, "protein_name": "Myelin regulatory factor", "gene_name": "Myrf", "organism": "Mouse", "refseq_name": "myelin regulatory factor isoform 1", "refseq_ac": "NP_001028653", "gene_names_uniprotkb": "Myrf; Gm1804; Gm98; Mrf", "gene_names_refseq": "6030439E18; Gm1804; Gm98; Mrf; Myrf", "protein_names_uniprotkb": "Myelin regulatory factor; 3.4.-.-; Myelin gene regulatory factor", "protein_names_refseq": "myelin gene regulatory factor; myelin regulatory factor isoform 1", "tax_id": 10090, "disease": "nanophthalmos (Disease Ontology:DOID:0080634); primary angle-closure glaucoma (Disease Ontology:DOID:1405); cerebral infarction (Disease Ontology:DOID:3526); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); eye disease (Disease Ontology:DOID:5614); hyperopia (Disease Ontology:DOID:9834)", "pathway": " (mmu:225908)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "19596243;21750661;21938520;22956843;23966833;24204311;25428506;27532821;28441531;28623291;30249802;31048900;31599954", "class_list": "", "function": "Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes., [UniProtKB, PubMed, PubMed]; Expression of MRF within the adult central nervous system (CNS) is critical to maintain oligodendrocyte identity and integrity of CNS myelin., [RefSeq, PubMed]; Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage., [UniProtKB, PubMed]; NPC1 protein was expressed in oligodendrocytes and the amount of myelin protein was generally decreased in all parts of the brain and spinal cord in NPC1-mutant mice, [RefSeq, PubMed]; Study identifies gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination., [RefSeq, PubMed]; Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:19596243, PubMed:22956843, PubMed:23966833, PubMed:24204311, PubMed:27532821). Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:19596243, PubMed:22956843, PubMed:23966833)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RXQ7;F8WJJ9;Q3V3K4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0022010 central nervous system myelination;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3UR85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FW60-1", "uniprot_id": "MUP20_MOUSE", "mass": 20930.0, "length": 181, "protein_name": "Major urinary protein 20", "gene_name": "Mup20", "organism": "Mouse", "refseq_name": "major urinary protein 20 precursor", "refseq_ac": "NP_001012323", "gene_names_uniprotkb": "Mup20; Mup24", "gene_names_refseq": "Gm12560; Mup20; Mup24; darcin", "protein_names_uniprotkb": "Major urinary protein 20; Darcin; Major urinary protein 24", "protein_names_refseq": "major urinary protein 20 precursor; major urinary protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:381530)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15934926;18064011;18815613;20525243;23239735;25279835;25972792;28522864;30670733;31996852", "class_list": "", "function": "14 critical amino acids in the binding pocket involved in ligand interactions were identified in MUP20 using in silico techniques and 7 MUP20 mutants were synthesized and characterized to produce a set of proteins with diverse ligand binding profiles Publication Status: Online-Only, [RefSeq, PubMed]; Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male (PubMed:20525243, PubMed:31996852). Promotes spatial learning by rapidly conditioning preference for its remembered location among females and competitor males so that animals prefer to spend time in the site even when scent is absent (PubMed:23239735). In addition to promoting a rapid attraction response, also elicits ultrasonic vocalizations and urinary scent marking in females which do not occur immediately after exposure (PubMed:31996852). Stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in females (PubMed:25972792). Promotes male aggressive behavior (PubMed:18064011). Response to Mup20 is mediated by a neural circuit extending from the accessory olfactory bulb to a subset of nitric oxidase synthase-expressing neurons in the medial amygdala (PubMed:31996852). As well as acting as a pheromone itself, binds most of the male pheromone, 2-sec-butyl-4,5-dihydrothiazole, in urine and is responsible for its slow release from scent marks (PubMed:15934926, PubMed:25279835)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000772 mating pheromone activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0008355 olfactory learning;GO:2000179 positive regulation of neural precursor cell proliferation;GO:0050769 positive regulation of neurogenesis;GO:0071625 vocalization behavior", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5FW60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SX39-1", "uniprot_id": "MYH4_MOUSE", "mass": 222859.0, "length": 1939, "protein_name": "Myosin-4", "gene_name": "Myh4", "organism": "Mouse", "refseq_name": "myosin-4", "refseq_ac": "NP_034985", "gene_names_uniprotkb": "Myh4", "gene_names_refseq": "MHC2B; MM; MYH-2B; Minimsc; Minmus; MyHC-IIb; Myh4; Myhsf", "protein_names_uniprotkb": "Myosin-4; MyHC-2b; Myosin heavy chain 2b; Myosin heavy chain 4", "protein_names_refseq": "myHC-2b; myosin heavy chain 2b; myosin heavy chain 4; myosin-4", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); sciatic neuropathy (Disease Ontology:DOID:11446); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:17884)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428506;30084848;36064721;37507081;39927985", "class_list": "", "function": "Muscle contraction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ73", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003725 double-stranded RNA binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016460 myosin II complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0014850 response to muscle activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5SX39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SX40-1", "uniprot_id": "MYH1_MOUSE", "mass": 223342.0, "length": 1942, "protein_name": "Myosin-1", "gene_name": "Myh1", "organism": "Mouse", "refseq_name": "myosin-1", "refseq_ac": "NP_109604", "gene_names_uniprotkb": "Myh1", "gene_names_refseq": "A530084A17Rik; IId/x; IId; MHC-2X/D; MHC2X/D; MYHC-IIX; MdMs; MyHC-IId/x; MyHC-IIx/d; Myh1; Myhs-f2; Myhs-f; Myhsf2", "protein_names_uniprotkb": "Myosin-1; MyHC-2x; Myosin heavy chain 1; Myosin heavy chain 2x; Myosin heavy chain, skeletal muscle, adult 1", "protein_names_refseq": "myHC-2x; myosin heavy chain 1; myosin heavy chain 2X; myosin heavy chain, skeletal muscle, adult 1; myosin-1", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:17879)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "36064721;37507081;39482536;39627609;39927985", "class_list": "", "function": "Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32P18", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0014704 intercalated disc;GO:0032982 myosin filament;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0006936 muscle contraction;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5SX40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61468-1", "uniprot_id": "MSLN_MOUSE", "mass": 69423.0, "length": 625, "protein_name": "Mesothelin", "gene_name": "Msln", "organism": "Mouse", "refseq_name": "mesothelin isoform 1 preproprotein", "refseq_ac": "NP_061345", "gene_names_uniprotkb": "Msln; Mes; Mpf", "gene_names_refseq": "C-ERC; MPF; Msln", "protein_names_uniprotkb": "Mesothelin; Pre-pro-megakaryocyte-potentiating factor", "protein_names_refseq": "megakaryocyte potentiating factor; mesothelin isoform 1 preproprotein; pre-pro-megakaryocyte-potentiating factor", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); pancreas disease (Disease Ontology:DOID:26); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); common bile duct neoplasm (Disease Ontology:DOID:4608); bile duct carcinoma (Disease Ontology:DOID:4897)", "pathway": " (mmu:56047); (R-MMU-163125); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10733593;12697065;14676194;21750661;31599954;38356442", "class_list": "", "function": "Binding of membrane-bound mesothelin to ovarian cancer antigen CA125 mediates heterotypic cell adhesion, [RefSeq, PubMed]; Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis., [RefSeq, PubMed]; Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation., [UniProtKB, UniProtKB, UniProtKB]; Membrane-anchored forms may play a role in cellular adhesion., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61468-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62082-1", "uniprot_id": "MYL10_MOUSE", "mass": 22511.0, "length": 202, "protein_name": "Myosin regulatory light chain 10", "gene_name": "Myl10", "organism": "Mouse", "refseq_name": "myosin regulatory light chain 10 isoform 2", "refseq_ac": "NP_001078856", "gene_names_uniprotkb": "Myl10; Mylc2pl; Plrlc", "gene_names_refseq": "1700027I08Rik; Myl10; Mylc2pl; PLRLC", "protein_names_uniprotkb": "Myosin regulatory light chain 10; Myosin light chain 2, lymphocyte-specific; Precursor lymphocyte-specific regulatory light chain", "protein_names_refseq": "myosin light chain 2, precursor lymphocyte-specific; myosin regulatory light chain 10 isoform 2; myosin regulatory light chain 10; precursor lymphocyte-specific regulatory light chain", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)", "pathway": " (mmu:59310); (R-MMU-445355)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1628631;21750661;30779550", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62080", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66X19-1", "uniprot_id": "NAL4E_MOUSE", "mass": 112473.0, "length": 978, "protein_name": "NACHT, LRR and PYD domains-containing protein 4E", "gene_name": "Nlrp4e", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 4E", "refseq_ac": "NP_001004194", "gene_names_uniprotkb": "Nlrp4e; Nalp4e; Nlrp4", "gene_names_refseq": "4930406H16Rik; Nalp-epsilon; Nalp4e; Nlrp4e; Nlrp4", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 4E; NALP-epsilon", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 4E; NACHT, leucine rich repeat and PYD containing 4E; NALP, epsilon; NLR family, pyrin domain containing 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:446099)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15317747;23708922;24453428;27692986;38730334", "class_list": "", "function": "May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors., [UniProtKB]; NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; Suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a pivotal role in tumor development in murine models of melanoma, [RefSeq, PubMed]; That Nlrp4e, a maternal-zygotic-effect gene, may not be involved in oocyte maturation but may play a critical role in early embryogenesis., [RefSeq, PubMed]; USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050727 regulation of inflammatory response;GO:0070936 protein K48-linked ubiquitination;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66X19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P8Z1-1", "uniprot_id": "MYCB_MOUSE", "mass": 18526.0, "length": 170, "protein_name": "Protein B-Myc", "gene_name": "Mycb", "organism": "Mouse", "refseq_name": "protein B-Myc", "refseq_ac": "NP_075815", "gene_names_uniprotkb": "Mycb; Bmyc", "gene_names_refseq": "2900002K07Rik; Bmyc; Mycb", "protein_names_uniprotkb": "Protein B-Myc", "protein_names_refseq": "protein B-Myc", "tax_id": 10090, "disease": "", "pathway": " (mmu:107771)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11039906;22869780;34428180", "class_list": "", "function": "Data from knockout mice suggest that Bmyc is a regulator of Myc (myelocytomatosis oncogene) in vivo and that overexpression of Myc in developing testis leads to increased apoptosis of spermatogenic cells., [RefSeq, PubMed]; Seems to act as an inhibitor of cellular proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6E3", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P8Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q791V5-1", "uniprot_id": "MTCH2_MOUSE", "mass": 33499.0, "length": 303, "protein_name": "Mitochondrial carrier homolog 2", "gene_name": "Mtch2", "organism": "Mouse", "refseq_name": "mitochondrial carrier homolog 2 isoform 1x", "refseq_ac": "NP_001304170", "gene_names_uniprotkb": "Mtch2; Mimp", "gene_names_refseq": "2310034D24Rik; 4930539J07Rik; HSPC032; Mtch2", "protein_names_uniprotkb": "Mitochondrial carrier homolog 2; Met-induced mitochondrial protein", "protein_names_refseq": "met-induced mitochondrial protein; mitochondrial carrier homolog 2 isoform 1x; mitochondrial carrier homolog 2", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:56428)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12407445;15899861;20436477;21750661;22645316;25153642;26219591;26876167;28127879;28528544;30510213;32247615;33300544;33652185;34428180;36288343;37453647;38492919", "class_list": "", "function": "Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer., [RefSeq, PubMed]; Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric adipose tissue of obese mice., [RefSeq, PubMed]; Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (PubMed:20436477, PubMed:26219591, PubMed:26876167, PubMed:30510213). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (PubMed:20436477, PubMed:26219591, PubMed:26876167). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (PubMed:30510213). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (PubMed:26876167, PubMed:28127879)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Silica nanoparticles inducing the apoptosis via microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell., [RefSeq, PubMed]; This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPS5;Q99LZ6;Q9D060;Q9D7Y2;Q9QZP3", "ec_number_list": "", "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0090152 establishment of protein localization to mitochondrial membrane involved in mitochondrial fission;GO:0070585 protein localization to mitochondrion;GO:0045040 protein insertion into mitochondrial outer membrane;GO:0043065 positive regulation of apoptotic process;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q791V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M758-1", "uniprot_id": "NALDL_MOUSE", "mass": 80513.0, "length": 745, "protein_name": "Aminopeptidase NAALADL1", "gene_name": "Naaladl1", "organism": "Mouse", "refseq_name": "aminopeptidase NAALADL1", "refseq_ac": "NP_001009546", "gene_names_uniprotkb": "Naaladl1; Gm964; Naaladasel", "gene_names_refseq": "Gm964; Naaladasel; Naaladl1", "protein_names_uniprotkb": "Aminopeptidase NAALADL1; 3.4.11.-; N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L", "protein_names_refseq": "N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; aminopeptidase NAALADL1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381204)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12838346;30084848", "class_list": "", "function": "Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0004180 carboxypeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSZ8-1", "uniprot_id": "NACC1_MOUSE", "mass": 56537.0, "length": 514, "protein_name": "Nucleus accumbens-associated protein 1", "gene_name": "Nacc1", "organism": "Mouse", "refseq_name": "nucleus accumbens-associated protein 1", "refseq_ac": "NP_080064", "gene_names_uniprotkb": "Nacc1; Btbd14b; Nac1", "gene_names_refseq": "2010001H03Rik; 4930511N13Rik; Btbd14b; Nac1; Nacc1", "protein_names_uniprotkb": "Nucleus accumbens-associated protein 1; BTB/POZ domain-containing protein 14B; NAC-1", "protein_names_refseq": "BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; NAC-1; nucleus accumbens-associated protein 1; transcriptional repressor NAC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66830)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14521994;17130457;17945361;21183079;21750661;28315936;31599954;36150745;37465969;38388424;40997131", "class_list": "", "function": "Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines., [UniProtKB, PubMed, PubMed]; NAC1 confines virus-specific memory formation of CD4[+] T cells through the ROCK1-mediated pathway., [RefSeq, PubMed]; Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; The mouse Nac1 gene consist of six exons, with exon 2 containing an alternative splice donor, providing a molecular explanation of the splice variants observed in mouse and rat., [RefSeq, PubMed]; Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80X97;Q9CZ72", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030054 cell junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TSZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UW5-1", "uniprot_id": "MRCKG_MOUSE", "mass": 172147.0, "length": 1551, "protein_name": "Serine/threonine-protein kinase MRCK gamma", "gene_name": "Cdc42bpg", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase MRCK gamma", "refseq_ac": "NP_001028514", "gene_names_uniprotkb": "Cdc42bpg", "gene_names_refseq": "Cdc42bpg; MRCKgamma", "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK gamma; 2.7.11.1; CDC42-binding protein kinase gamma; DMPK-like gamma; MRCK gamma; Myotonic dystrophy kinase-related CDC42-binding kinase gamma; Myotonic dystrophy protein kinase-like alpha; Myotonic dystrophy protein kinase-like gamma", "protein_names_refseq": "CDC42 binding protein kinase gamma (DMPK-like); DMPK-like gamma; MRCK gamma; myotonic dystrophy kinase-related CDC42-binding kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; serine/threonine-protein kinase MRCK gamma", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:240505)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19402746;25428506;30084848;30779550;31219806;33921698;34203471;34428180;35820727", "class_list": "", "function": "MRCKalpha Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model. Publication Status: Online-Only, [RefSeq, PubMed]; MRCKgamma can modulate maturation of dendritic spines in cultured cortical neurons, and it is localized specifically to parallel fiber/Purkinje cell synapses in vivo., [RefSeq, PubMed]; May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0031252 cell leading edge;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030036 actin cytoskeleton organization;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80UW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YT7-1", "uniprot_id": "MYOME_MOUSE", "mass": 250631.0, "length": 2224, "protein_name": "Myomegalin", "gene_name": "Pde4dip", "organism": "Mouse", "refseq_name": "myomegalin isoform 1", "refseq_ac": "NP_001034465", "gene_names_uniprotkb": "Pde4dip; Kiaa0454", "gene_names_refseq": "4732458A06Rik; 9430063L05Rik; D130016K21Rik; D3Bwg1078e; Pde4dip; Usmg4; mKIAA0454", "protein_names_uniprotkb": "Myomegalin; Phosphodiesterase 4D-interacting protein", "protein_names_refseq": "myomegalin isoform 1; myomegalin; phosphodiesterase 4D-interacting protein; upregulated during skeletal muscle growth 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:83679)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;34428180;36210013", "class_list": "", "function": "Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity)., [UniProtKB, UniProtKB]; Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9848, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "C4IXU1;Q05CH5;Q80U00;Q8K240", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0030016 myofibril", "go_biological_process": "GO:0007098 centrosome cycle;GO:0090063 positive regulation of microtubule nucleation;GO:0030953 astral microtubule organization;GO:0065003 protein-containing complex assembly;GO:1903358 regulation of Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80YT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHZ5-1", "uniprot_id": "CYREN_MOUSE", "mass": 17287.0, "length": 157, "protein_name": "Cell cycle regulator of non-homologous end joining", "gene_name": "Cyren", "organism": "Mouse", "refseq_name": "cell cycle regulator of non-homologous end joining isoform 1", "refseq_ac": "NP_001129083", "gene_names_uniprotkb": "Cyren; 3110062M04Rik; Mri", "gene_names_refseq": "3110062M04Rik; Cyren; Mri", "protein_names_uniprotkb": "Cell cycle regulator of non-homologous end joining; Cell cycle regulator of NHEJ; Modulator of retrovirus infection homolog", "protein_names_refseq": "cell cycle regulator of non-homologous end joining isoform 1; cell cycle regulator of non-homologous end joining; modulator of retrovirus infection homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78412)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17043244;21750661;30017584;31795137;32355287;33289702", "class_list": "", "function": "Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:30017584). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (By similarity). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (By similarity). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin (PubMed:30017584). Also involved in immunoglobulin V(D)J recombination (PubMed:30017584, PubMed:31795137). May also act as an indirect regulator of proteasome (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection., [RefSeq, PubMed]; Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0Y5", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035861 site of double-strand break;GO:1990391 DNA repair complex", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0051260 protein homooligomerization;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BHZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM54-1", "uniprot_id": "MYLIP_MOUSE", "mass": 49849.0, "length": 445, "protein_name": "E3 ubiquitin-protein ligase MYLIP", "gene_name": "Mylip", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MYLIP", "refseq_ac": "NP_722484", "gene_names_uniprotkb": "Mylip", "gene_names_refseq": "9430057C20Rik; Mir; Mylip", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MYLIP; 2.3.2.27; Idol; Inducible degrader of the LDL-receptor; MIR; Myosin regulatory light chain-interacting protein; RING-type E3 ubiquitin transferase MYLIP", "protein_names_refseq": "E3 ubiquitin-protein ligase MYLIP; RING-type E3 ubiquitin transferase MYLIP; idol; inducible degrader of the LDL-receptor", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:218203); (R-MMU-8866427); (R-MMU-983168)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "14651927;16479539;19520913;20173027;20427281;20562239;25428506;30084848;31219806;32152506;34203471;34428180;36210013", "class_list": "", "function": "Data show that NPC1 deficiency has a major impact on VLDL metabolism in Apoe(-/-) mice through modulation of hepatic LDL-R protein levels, and a modest one on Pcsk9 and Idol induction., [RefSeq, PubMed]; Data show that the identification of VLDLR and ApoER2 as Idol(Mylip) targets suggests potential roles for this LXR-inducible E3 ligase in the central nervous system in addition to lipid metabolism., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR., [UniProtKB, PubMed, PubMed]; Study shows the LXR-Idol(Mylip)-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX01;Q8BLY9;Q91Z47", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008092 cytoskeletal protein binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0010977 negative regulation of neuron projection development;GO:0042632 cholesterol homeostasis;GO:0010989 negative regulation of low-density lipoprotein particle clearance;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BM54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUR9-1", "uniprot_id": "MZT1_MOUSE", "mass": 8132.0, "length": 78, "protein_name": "Mitotic-spindle organizing protein 1", "gene_name": "Mzt1", "organism": "Mouse", "refseq_name": "mitotic-spindle organizing protein 1", "refseq_ac": "NP_780454", "gene_names_uniprotkb": "Mzt1; Mozart1", "gene_names_refseq": "2410129H14Rik; Mozart1; Mzt1", "protein_names_uniprotkb": "Mitotic-spindle organizing protein 1; Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1", "protein_names_refseq": "mitotic-spindle organizing protein 1; mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76789); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20360068;21750661", "class_list": "", "function": "Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0031021 interphase microtubule organizing center;GO:0000931 gamma-tubulin ring complex", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0033566 gamma-tubulin complex localization;GO:0051415 microtubule nucleation by interphase microtubule organizing center", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BUR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDZ2-1", "uniprot_id": "MT21E_MOUSE", "mass": 28067.0, "length": 244, "protein_name": "Protein-lysine methyltransferase METTL21E", "gene_name": "Mettl21e", "organism": "Mouse", "refseq_name": "protein-lysine methyltransferase METTL21E", "refseq_ac": "NP_997164", "gene_names_uniprotkb": "Mettl21e", "gene_names_refseq": "4832428D23Rik; Gm991; Mettl21e", "protein_names_uniprotkb": "Protein-lysine methyltransferase METTL21E; 2.1.1.-; Methyltransferase-like protein 21E", "protein_names_refseq": "methyltransferase-like protein 21C pseudogene 1 homolog; methyltransferase-like protein 21E pseudogene homolog; methyltransferase-like protein LOC121952 homolog; protein-lysine methyltransferase METTL21E", "tax_id": 10090, "disease": "", "pathway": " (mmu:403183)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine methyltransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008276 protein methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CDZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHZ9-1", "uniprot_id": "MTF1A_MOUSE", "mass": 43815.0, "length": 379, "protein_name": "Transcription termination factor 1a, mitochondrial", "gene_name": "Mterf1a", "organism": "Mouse", "refseq_name": "transcription termination factor 1a, mitochondrial precursor", "refseq_ac": "NP_001013041", "gene_names_uniprotkb": "Mterf1a; Mterf1; Mterf", "gene_names_refseq": "4931431L11Rik; 9230106K09Rik; Mterf1a; Mterf1; Mterf; mTERF1b", "protein_names_uniprotkb": "Transcription termination factor 1a, mitochondrial; Mitochondrial transcription termination factor 1a; mTERF1a", "protein_names_refseq": "mitochondrial transcription termination factor 1b; mitochondrial transcription termination factor 1; transcription termination factor 1a, mitochondrial precursor; transcription termination factor 1a, mitochondrial; transcription termination factor, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:545725)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15582606;23562081;25428506;30084848;30779550", "class_list": "", "function": "MTERF1 does not regulate heavy-strand transcription, but rather acts to block transcription on the opposite strand of mtDNA to prevent transcription interference at the light-strand promoter., [RefSeq, PubMed]; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63ZX5;Q8C7T1", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006393 termination of mitochondrial transcription;GO:0006353 DNA-templated transcription termination;GO:0032392 DNA geometric change", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CHZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI43-1", "uniprot_id": "MYL6B_MOUSE", "mass": 22749.0, "length": 207, "protein_name": "Myosin light chain 6B", "gene_name": "Myl6b", "organism": "Mouse", "refseq_name": "myosin light chain 6B", "refseq_ac": "NP_758463", "gene_names_uniprotkb": "Myl6b", "gene_names_refseq": "5730437E04Rik; MLC1SA; Myl6b", "protein_names_uniprotkb": "Myosin light chain 6B; Smooth muscle and nonmuscle myosin light chain alkali 6B", "protein_names_refseq": "myosin light chain 1 slow a; myosin light chain 6B; smooth muscle and nonmuscle myosin light chain alkali 6B", "tax_id": 10090, "disease": "", "pathway": " (mmu:216459); (R-MMU-445355)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0003774 cytoskeletal motor activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0016459 myosin complex;GO:0016460 myosin II complex;GO:0016461 unconventional myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CI43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZS6-1", "uniprot_id": "N42L2_MOUSE", "mass": 66250.0, "length": 575, "protein_name": "NEDD4-binding protein 2-like 2", "gene_name": "N4bp2l2", "organism": "Mouse", "refseq_name": "NEDD4-binding protein 2-like 2 isoform 2", "refseq_ac": "NP_958757", "gene_names_uniprotkb": "N4bp2l2; Pfaap5", "gene_names_refseq": "2700092H06Rik; Gm38758; N4bp2l2; zag1", "protein_names_uniprotkb": "NEDD4-binding protein 2-like 2; Phosphonoformate immuno-associated protein 5 homolog", "protein_names_refseq": "NEDD4-binding protein 2-like 2 isoform 2; phosphonoformate immuno-associated protein 5 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:381695)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18360097;18815245;21750661;31219806;34428180", "class_list": "", "function": "Increased Zag expression in the aged kidney acts to suppress the proliferative response to injury, [RefSeq, PubMed]; Results suggest that ZAG1 may be closely associated with zygotic gene expression in mouse preimplantation embryos, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex", "go_biological_process": "GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:1902035 positive regulation of hematopoietic stem cell proliferation;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8JZS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4H7-1", "uniprot_id": "NAGS_MOUSE", "mass": 57489.0, "length": 527, "protein_name": "N-acetylglutamate synthase, mitochondrial", "gene_name": "Nags", "organism": "Mouse", "refseq_name": "N-acetylglutamate synthase, mitochondrial precursor", "refseq_ac": "NP_665828", "gene_names_uniprotkb": "Nags", "gene_names_refseq": "1700120E20Rik; Nags; argA", "protein_names_uniprotkb": "N-acetylglutamate synthase, mitochondrial; 2.3.1.1; Amino-acid acetyltransferase", "protein_names_refseq": "N-acetylglutamate synthase, mitochondrial precursor; N-acetylglutamate synthase, mitochondrial; amino-acid N-acetyltransferase; amino-acid acetyltransferase", "tax_id": 10090, "disease": "N-acetylglutamate synthase deficiency (Disease Ontology:DOID:0112258); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:217214); (R-MMU-70635)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12049647;15050968;22383952;23894642;27771289;33574402;34428180", "class_list": "", "function": "Gene delivery corrects N-acetylglutamate synthase deficiency and enables insights in the physiological impact of L-arginine activation of N-acetylglutamate synthase. Publication Status: Online-Only, [RefSeq, PubMed]; Identification, cloning and expression, [RefSeq, PubMed]; Is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) Review article, [RefSeq, PubMed]; Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity., [UniProtKB, PubMed]; Sp1, CREB, HNF-1, and NF-Y, known to be responsive to hormones and diet, regulate NAGS transcription, [RefSeq, PubMed]; The specificity of the assay was validated by demonstrating a complete deficiency of NAGS in liver homogenates from Nags -/- mice. CONCLUSION: The novel NAGS enzyme assay reported herein can be used for the diagnosis of inherited NAGS deficiency and may also be of value in the study of secondary hyperammonemia present in various inborn errors of metabolism as well as drug treatment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AQG2;Q8C6G6;Q8CI77;Q8K1R8", "ec_number_list": "2.3.1.1", "go_molecular_function": "GO:0004042 L-glutamate N-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006536 glutamate metabolic process;GO:0000050 urea cycle;GO:0006526 L-arginine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R4H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI47-1", "uniprot_id": "MRP2_MOUSE", "mass": 173671.0, "length": 1543, "protein_name": "ATP-binding cassette sub-family C member 2", "gene_name": "Abcc2", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 2", "refseq_ac": "NP_038834", "gene_names_uniprotkb": "Abcc2", "gene_names_refseq": "Abc30; Abcc2; Cmoat; Mrp2; cMRP", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 2; 7.6.2.-; 7.6.2.2; 7.6.2.3; Canalicular multispecific organic anion transporter 1; MRP2; Multidrug resistance-associated protein 2", "protein_names_refseq": "ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette, sub-family member 2; canalicular multispecific organic anion transporter 1; multidrug resistance protein 2; multidrug resistance-associated protein 2", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); drug-induced hepatitis (Disease Ontology:DOID:2044); bilirubin metabolic disorder (Disease Ontology:DOID:2741); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12780); (R-MMU-189483); (R-MMU-382556); (R-MMU-9749641); (R-MMU-9753281); (R-MMU-9754706)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16421286;21183079;25428506;30084848;32753644;34428180;35444014", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of endogenous and xenobiotic substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells, where it mediates hepatobiliary and renal excretion of conjugated substrates preventing them from being recycled back into the bloodstream (By similarity). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (By similarity). Involved in renal excretion and enterohepatic recirculation of steroid glucuronates. Displays low affinity but high transporter velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (By similarity). May control the hepatobiliary and renal efflux of inflammatory leukotriene C4 (LTC4) and related cysteinyl leukotrienes (By similarity). Transports sulfated bile salt such as taurolithocholate sulfate. It is functionally inactive toward androgen sulfates (By similarity). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression., [RefSeq, PubMed]; Reduced Mrp2 surface availability as PI3Kgamma-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI46", "ec_number_list": "7.6.2.2;7.6.2.-;7.6.2.3;7.6.2.1;5.6.1.6", "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0046581 intercellular canaliculus", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0030644 intracellular chloride ion homeostasis;GO:0034635 glutathione transport;GO:0007507 heart development;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VI47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X91-1", "uniprot_id": "NADC_MOUSE", "mass": 31530.0, "length": 299, "protein_name": "Nicotinate-nucleotide pyrophosphorylase [carboxylating]", "gene_name": "Qprt", "organism": "Mouse", "refseq_name": "nicotinate-nucleotide pyrophosphorylase [carboxylating]", "refseq_ac": "NP_598447", "gene_names_uniprotkb": "Qprt", "gene_names_refseq": "2410027J01Rik; QPRTase; Qprt", "protein_names_uniprotkb": "Nicotinate-nucleotide pyrophosphorylase [carboxylating]; 2.4.2.19; QAPRTase; QPRTase; Quinolinate phosphoribosyltransferase [decarboxylating]", "protein_names_refseq": "QAPRTase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); pellagra (Disease Ontology:DOID:8457)", "pathway": " (mmu:67375); (R-MMU-196807)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;28724915;33613454;34428180;37078472;37453647;37783445", "class_list": "", "function": "Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex-specific pattern., [RefSeq, PubMed]; Hepatic QPRT thus likely served as a cellular factor that dampened productive hepatitis c virus replication. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatocyte nuclear factor 4alpha mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury., [RefSeq, PubMed]; Involved in the catabolism of quinolinic acid (QA)., [UniProtKB, UniProtKB]; Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.19", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1902494 catalytic complex", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034213 quinolinate catabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan;GO:0046874 quinolinate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91X91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPT3-1", "uniprot_id": "NANP_MOUSE", "mass": 27808.0, "length": 248, "protein_name": "N-acylneuraminate-9-phosphatase", "gene_name": "Nanp", "organism": "Mouse", "refseq_name": "N-acylneuraminate-9-phosphatase", "refseq_ac": "NP_080362", "gene_names_uniprotkb": "Nanp; Hdhd4", "gene_names_refseq": "1600031M04Rik; Hdhd4; Nanp", "protein_names_uniprotkb": "N-acylneuraminate-9-phosphatase; 3.1.3.29; Haloacid dehalogenase-like hydrolase domain-containing protein 4; N-acetylneuraminate-9-phosphate phosphatase; Neu5Ac-9-Pase", "protein_names_refseq": "N-acetylneuraminate-9-phosphate phosphatase; N-acylneuraminate-9-phosphatase; haloacid dehalogenase-like hydrolase domain containing 4; haloacid dehalogenase-like hydrolase domain-containing protein 4; neu5Ac-9-Pase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67311); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32848054", "class_list": "", "function": "Catalyzes the dephosphorylation of N-acylneuraminate 9-phosphate (Neu5Ac-9-P) to sialic acid N-acetylneuraminic acid (Neu5Ac). May also use N-glycoloylneuraminate 9-phosphate as substrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.29", "go_molecular_function": "GO:0050124 N-acylneuraminate-9-phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006045 N-acetylglucosamine biosynthetic process;GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process;GO:0046380 N-acetylneuraminate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CPT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5Z5-1", "uniprot_id": "MSS51_MOUSE", "mass": 49950.0, "length": 446, "protein_name": "Putative protein MSS51 homolog, mitochondrial", "gene_name": "Mss51", "organism": "Mouse", "refseq_name": "putative protein MSS51 homolog, mitochondrial", "refseq_ac": "NP_083380", "gene_names_uniprotkb": "Mss51; Zmynd17", "gene_names_refseq": "4833444M15Rik; Mss51; Zmynd17", "protein_names_uniprotkb": "Putative protein MSS51 homolog, mitochondrial; Zinc finger MYND domain-containing protein 17", "protein_names_refseq": "putative protein MSS51 homolog, mitochondrial; zinc finger MYND domain-containing protein 17; zinc finger, MYND domain containing 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:74843)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "29913553;31219806;33423297;37002920", "class_list": "", "function": "Indicate that Zmynd17 is a metabolic stress-inducible factor that maintains muscle mitochondrial integrity, [RefSeq, PubMed]; Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy., [RefSeq, PubMed]; Site-1 protease inhibits mitochondrial respiration by controlling the TGF-beta target gene Mss51., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VD61", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D5Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6A1-1", "uniprot_id": "MYO1H_MOUSE", "mass": 109993.0, "length": 958, "protein_name": "Unconventional myosin-Ih", "gene_name": "Myo1h", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Myo1h", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-Ih", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (mmu:231646)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12486594;21750661;25428506;28779001", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZI2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005902 microvillus;GO:0016459 myosin complex", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D6A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCJ5-1", "uniprot_id": "NDUA8_MOUSE", "mass": 19992.0, "length": 172, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "gene_name": "Ndufa8", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "refseq_ac": "NP_080979", "gene_names_uniprotkb": "Ndufa8", "gene_names_refseq": "0610033L03Rik; CI-19kD; CI-PGIV; Ndufa8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; CI-19kD; CI-PGIV; Complex I-19kD; Complex I-PGIV; NADH-ubiquinone oxidoreductase 19 kDa subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; NADH-ubiquinone oxidoreductase 19 kDa subunit; complex I-19kD; complex I-PGIV", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency (Disease Ontology:DOID:0112065)", "pathway": " (mmu:68375); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "25428506;32574643;34428180;36288343;37453647;37507081;38575788;39127135;39927985", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Ndufa8 promotes white fat Browning by improving mitochondrial respiratory chain complex I function to ameliorate obesity by in vitro and in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AL45", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DCJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERS2-1", "uniprot_id": "NDUAD_MOUSE", "mass": 16860.0, "length": 144, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "gene_name": "Ndufa13", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "refseq_ac": "NP_075801", "gene_names_uniprotkb": "Ndufa13; Grim19", "gene_names_refseq": "2700054G14Rik; CDA016; CGI-39; CI-B16.6; GRIM-19; Grim19; Ndufa13", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; CI-B16.6; Cell death regulatory protein GRIM-19; Complex I-B16.6; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; Gene associated with retinoic and interferon-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; NADH-ubiquinone oxidoreductase B16.6 subunit; cell death regulatory protein GRIM-19; complex I-B16.6; gene associated with retinoic and IFN-induced mortality 19 protein; gene associated with retinoic and interferon-induced mortality 19 protein; gene associated with retinoic-interferon-induced mortality 19 protein; genes associated with retinoid-IFN-induced mortality 19", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 28 (Disease Ontology:DOID:0112095); Parkinson's disease (Disease Ontology:DOID:14330); cerebral infarction (Disease Ontology:DOID:3526); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161)", "pathway": " (mmu:67184); (R-MMU-611105); (R-MMU-6799198); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10924506;12163600;12628925;12867595;36288343;38360073;38575788;39158709", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes., [UniProtKB, PubMed]; GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS., [RefSeq, PubMed]; Results collectively indicate that viral interferon regulatory factor 1 modulates interferon/retinoic acid-cell death signals via interactions with GRIM19, [RefSeq, PubMed]; SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC98;Q9DCA1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0071300 cellular response to retinoic acid;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0045892 negative regulation of DNA-templated transcription;GO:0097191 extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ERS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZZ4-1", "uniprot_id": "MYO15_MOUSE", "mass": 395622.0, "length": 3511, "protein_name": "Unconventional myosin-XV", "gene_name": "Myo15a", "organism": "Mouse", "refseq_name": "unconventional myosin-XV isoform 3", "refseq_ac": "NP_001096641", "gene_names_uniprotkb": "Myo15a; Myo15", "gene_names_refseq": "Myo15a; Myo15; sh-2; sh2", "protein_names_uniprotkb": "Unconventional myosin-XV; Unconventional myosin-15", "protein_names_refseq": "shaker 2; unconventional myosin-15; unconventional myosin-XV isoform 3; unconventional myosin-XV", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 3 (Disease Ontology:DOID:0110488); sensorineural hearing loss (Disease Ontology:DOID:10003); blindness (Disease Ontology:DOID:1432)", "pathway": " (mmu:17910)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10552926;14610277;15654330;21236676;21750661;25428506;31219806;35820727;9603735;9703981", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A637;A2A638;O70395;Q5SX93;Q7TMR5;Q7TMR6;Q9QWL6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QZZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVP9-1", "uniprot_id": "MX2_MOUSE", "mass": 74292.0, "length": 655, "protein_name": "Interferon-induced GTP-binding protein Mx2", "gene_name": "Mx2", "organism": "Mouse", "refseq_name": "interferon-induced GTP-binding protein Mx2", "refseq_ac": "NP_038634", "gene_names_uniprotkb": "Mx2", "gene_names_refseq": "Mx-2; Mx2", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein Mx2; Myxovirus resistance protein 2", "protein_names_refseq": "interferon-induced GTP-binding protein Mx2; myxovirus (influenza virus) resistance 2; myxovirus resistance protein 2", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease dominant intermediate B (Disease Ontology:DOID:0110197); centronuclear myopathy 1 (Disease Ontology:DOID:0111223); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); prostate cancer (Disease Ontology:DOID:10283); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); microcytic anemia (Disease Ontology:DOID:11252); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); hereditary spastic paraplegia (Disease Ontology:DOID:2476); liver disease (Disease Ontology:DOID:409); avian influenza (Disease Ontology:DOID:4492); myocardial infarction (Disease Ontology:DOID:5844); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:17858); (R-MMU-1169408)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10233954;11266216;18062906", "class_list": "", "function": "Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV) and Hantaan virus (HNTV)., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to vesicular stomatitis virus, a member of the rhabdovirus family, but not to influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a frameshift that inactivates this gene product. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922L4", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009617 response to bacterium;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WVP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z304-1", "uniprot_id": "MYCS_MOUSE", "mass": 47680.0, "length": 431, "protein_name": "Protein S-Myc", "gene_name": "Mycs", "organism": "Mouse", "refseq_name": "protein S-Myc", "refseq_ac": "NP_034980", "gene_names_uniprotkb": "Mycs", "gene_names_refseq": "Mycs", "protein_names_uniprotkb": "Protein S-Myc", "protein_names_refseq": "protein S-Myc", "tax_id": 10090, "disease": "Feingold syndrome (Disease Ontology:DOID:0060464); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:17870)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12438760;9931502", "class_list": "", "function": "Has apoptosis-inducing activity., [UniProtKB]; Reassignment of Mycs gene to mouse chromosome XA1.2-2 by radiation hybrid mapping and fluorescence in situ hybridization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0Z1", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0019900 kinase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0071943 Myc-Max complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z304-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97459-1", "uniprot_id": "NPAS1_MOUSE", "mass": 63737.0, "length": 594, "protein_name": "Neuronal PAS domain-containing protein 1", "gene_name": "Npas1", "organism": "Mouse", "refseq_name": "neuronal PAS domain-containing protein 1 isoform 1", "refseq_ac": "NP_032744", "gene_names_uniprotkb": "Npas1", "gene_names_refseq": "MOP5; Npas1; bHLHe11", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 1; Neuronal PAS1", "protein_names_refseq": "neuronal PAS domain-containing protein 1 isoform 1; neuronal PAS domain-containing protein 1; neuronal PAS1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18142)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15347806;15635607;27782878;33731445;35820727;36443000;9012850", "class_list": "", "function": "A regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis, [RefSeq, PubMed]; May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (PubMed:27782878)., [UniProtKB, PubMed, PubMed, PubMed]; Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons., [RefSeq, PubMed]; Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001964 startle response;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97459-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q672J9-1", "uniprot_id": "NOX3_MOUSE", "mass": 64495.0, "length": 568, "protein_name": "NADPH oxidase 3", "gene_name": "Nox3", "organism": "Mouse", "refseq_name": "NADPH oxidase 3", "refseq_ac": "NP_945196", "gene_names_uniprotkb": "Nox3", "gene_names_refseq": "GP91-3; Nox3; het; nmf250", "protein_names_uniprotkb": "NADPH oxidase 3; 1.6.3.-", "protein_names_refseq": "NADPH oxidase 3; head-tilt", "tax_id": 10090, "disease": "", "pathway": " (mmu:224480); (R-MMU-5668599); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15014044;15326186;17140397", "class_list": "", "function": "An allelic series of mutations at the otoconia-deficient head tilt (het) locus, affecting the gene for NADPH oxidase 3 (Nox3), identifies Nox3 as a protein with a clear enzymatic function indispensable for otoconia morphogenesis, [RefSeq, PubMed]; NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (PubMed:15326186, PubMed:17140397). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (PubMed:15014044)., [UniProtKB, PubMed, PubMed, PubMed]; NOX3 is a relevant source of ROS generation in the cochlear and vestibular systems and that NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs., [RefSeq, PubMed]; This gene encodes a member of the NOX family of NADPH oxidases. These enzymes catalyze the transfer of electrons from NADPH to molecular oxygen to produce superoxide and other reactive oxygen species (ROS). The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia, which are crystalline structures of the inner ear involved in the perception of gravity and linear acceleration. In mouse mutations of this gene lead to the absence of otoconia and vestibular dysfunction. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6Y4Q8", "ec_number_list": "2.7.11.1;2.7.1.153;2.7.1.137;3.6.5.2;2.7.11.13;3.1.4.4;2.7.10.1;2.7.10.2;1.6.3.-;1.6.3.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity;GO:0106292 superoxide-generating NADPH oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0009590 detection of gravity;GO:0001659 temperature homeostasis;GO:0006952 defense response;GO:0048840 otolith development;GO:0009629 response to gravity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q672J9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q794H2-1", "uniprot_id": "NP1L3_MOUSE", "mass": 61377.0, "length": 544, "protein_name": "Nucleosome assembly protein 1-like 3", "gene_name": "Nap1l3", "organism": "Mouse", "refseq_name": "nucleosome assembly protein 1-like 3", "refseq_ac": "NP_620081", "gene_names_uniprotkb": "Nap1l3; Mb20", "gene_names_refseq": "MB20; Nap1l3", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 3; Brain-specific protein MB20; Histone chaperone NAP1L3", "protein_names_refseq": "brain-specific protein MB20; histone chaperone NAP1L3; nucleosome assembly protein 1-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:54561)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11161794;30046127", "class_list": "", "function": "Histone chaperone (By similarity). May play a role in cellular differentiation (PubMed:30046127)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AZU8;O54802", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q794H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SU6-1", "uniprot_id": "NPT2C_MOUSE", "mass": 63939.0, "length": 601, "protein_name": "Sodium-dependent phosphate transport protein 2C", "gene_name": "Slc34a3", "organism": "Mouse", "refseq_name": "sodium-dependent phosphate transport protein 2C isoform 1", "refseq_ac": "NP_543130", "gene_names_uniprotkb": "Slc34a3; Npt2c", "gene_names_refseq": "Npt2c-v1; Npt2c; NptIIc; Slc34a3; naPi-2c", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2C; Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; NaPi-2c; Sodium-phosphate transport protein 2C; Sodium/phosphate cotransporter 2C; Solute carrier family 34 member 3", "protein_names_refseq": "Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; sodium-dependent phosphate transport protein 2C isoform 1; sodium-dependent phosphate transport protein 2C; sodium-phosphate cotransporter IIC; sodium/phosphate cotransporter 2C; type IIc Na+/Pi-cotransporter; type IIc NaPi-cotransporter-v1", "tax_id": 10090, "disease": "hereditary hypophosphatemic rickets with hypercalciuria (Disease Ontology:DOID:0050947)", "pathway": " (mmu:142681); (R-MMU-427589)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12690469;15007650;16113079;19056871;29398136;30895530;32026654", "class_list": "", "function": "Acute regulation of NaPi-IIc protein by parathyroid hormone is involved in the inactivation of Na(+)-dependent Pi cotransporter activity and that phosphorylation of the transporter is involved in the rapid modification., [RefSeq, PubMed]; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:12690469, PubMed:16113079). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (PubMed:16113079)., [UniProtKB, PubMed, PubMed]; NaPi-IIc mRNA and protein was up-regulated by the low-Pi diet in all nephron generations analysed, [RefSeq, PubMed]; Nampt/NAD(+) system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels., [RefSeq, PubMed]; Npt2c maintains normal Ca metabolism, in part by modulating the vitamin D/fibroblast growth factor 23 axis., [RefSeq, PubMed]; Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q05AC3", "ec_number_list": "", "go_molecular_function": "GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0031982 vesicle;GO:0031526 brush border membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport;GO:0030643 intracellular phosphate ion homeostasis;GO:0044341 sodium-dependent phosphate transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80SU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W85-1", "uniprot_id": "NPM2_MOUSE", "mass": 23309.0, "length": 207, "protein_name": "Nucleoplasmin-2", "gene_name": "Npm2", "organism": "Mouse", "refseq_name": "nucleoplasmin-2 isoform 1", "refseq_ac": "NP_851990", "gene_names_uniprotkb": "Npm2", "gene_names_refseq": "Npm2", "protein_names_uniprotkb": "Nucleoplasmin-2", "protein_names_refseq": "nucleoplasmin-2 isoform 1; nucleoplasmin-2", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:328440)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12714744;18324673;21750661;28600324", "class_list": "", "function": "Core histones chaperone involved in chromatin reprogramming, especially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization., [UniProtKB]; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization., [UniProtKB, UniProtKB]; Findings demonstrate that the NPM2-based oocyte nucleolus is an essential platform for parental chromatin organization in early embryonic development., [RefSeq, PubMed]; Npm2 is a maternal effect gene critical for nuclear and nucleolar organization and embryonic development, [RefSeq, PubMed]; Promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters and to obttain the best promoter for oocytte gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BW23", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0045836 positive regulation of meiotic nuclear division;GO:0009994 oocyte differentiation;GO:0006338 chromatin remodeling;GO:0043085 positive regulation of catalytic activity;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80W85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R116-1", "uniprot_id": "NOTUM_MOUSE", "mass": 56584.0, "length": 503, "protein_name": "Palmitoleoyl-protein carboxylesterase NOTUM", "gene_name": "Notum", "organism": "Mouse", "refseq_name": "palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor", "refseq_ac": "NP_780472", "gene_names_uniprotkb": "Notum", "gene_names_refseq": "5730593N15Rik; Notum", "protein_names_uniprotkb": "Palmitoleoyl-protein carboxylesterase NOTUM; 3.1.1.98", "protein_names_refseq": "notum pectinacetylesterase homolog; palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor; palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:77583); (R-MMU-381426); (R-MMU-5362798); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17967162;18429952;21750661;25771893;38871845", "class_list": "glycogene", "function": "Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors., [UniProtKB, PubMed]; Describes the human ortholog, and analyzes both the human and mouse promoters., [RefSeq, PubMed]; Notum regulates the cusp and root patterns in mouse molar. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 9624, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ABZ5;A2ABZ6", "ec_number_list": "3.4.24.81;3.6.4.-;5.3.4.1;3.4.21.69;3.1.-.-;2.7.11.1;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.4.21.-;2.4.1.145;3.1.1.4;3.1.1.3;1.8.3.2;3.1.1.98;3.2.1.51;3.4.21.112", "go_molecular_function": "GO:1990699 palmitoleyl hydrolase activity;GO:0016298 lipase activity;GO:0140776 protein-containing complex destabilizing activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1990697 protein depalmitoleylation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R116-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P3D0-1", "uniprot_id": "NUD16_MOUSE", "mass": 21825.0, "length": 195, "protein_name": "U8 snoRNA-decapping enzyme", "gene_name": "Nudt16", "organism": "Mouse", "refseq_name": "U8 snoRNA-decapping enzyme", "refseq_ac": "NP_083661", "gene_names_uniprotkb": "Nudt16", "gene_names_refseq": "2310041H06Rik; 2810047L04Rik; 2900006H04Rik; Nudt16", "protein_names_uniprotkb": "U8 snoRNA-decapping enzyme; 3.6.1.62; 3.6.1.64; IDP phosphatase; IDPase; Inosine diphosphate phosphatase; Nucleoside diphosphate-linked moiety X motif 16; Nudix motif 16; m7GpppN-mRNA hydrolase", "protein_names_refseq": "IDP phosphatase; IDPase; U8 snoRNA-decapping enzyme; inosine diphosphate phosphatase; m7GpppN-mRNA hydrolase; nucleoside diphosphate-linked moiety X motif 16; nudix (nucleoside diphosphate linked moiety X)-type motif 16; nudix motif 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:75686); (R-MMU-2393930)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "20081199;20385596;21070968;21750661;26100207;26740625;31219806;32432673", "class_list": "", "function": "Binding interaction between syndesmos and syn4(cyto) was characterized as a low-affinity interaction (Kd = 62 muM) by surface plasmon resonance and nuclear magnetic resonance, [RefSeq, PubMed]; Like Dcp2, Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis., [RefSeq, PubMed]; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Also catalyzes the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation (By similarity). Also acts as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D716", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.1.5;3.1.13.-;3.6.1.-;3.6.1.77;3.6.1.17;3.6.1.6;3.6.1.9;3.6.1.68;3.6.1.76;3.6.1.59;3.6.1.52;3.6.1.10;3.6.1.61", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003729 mRNA binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0051276 chromosome organization;GO:0016077 sno(s)RNA catabolic process;GO:0035863 dITP catabolic process;GO:2000233 negative regulation of rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6P3D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80U93-1", "uniprot_id": "NU214_MOUSE", "mass": 212979.0, "length": 2085, "protein_name": "Nuclear pore complex protein Nup214", "gene_name": "Nup214", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup214 isoform 1", "refseq_ac": "NP_758472", "gene_names_uniprotkb": "Nup214; Kiaa0023", "gene_names_refseq": "CAN; D2H9S46E; Nup214", "protein_names_uniprotkb": "Nuclear pore complex protein Nup214; 214 kDa nucleoporin; Nucleoporin Nup214", "protein_names_refseq": "214 kDa nucleoporin; nuclear pore complex protein Nup214 isoform 1; nuclear pore complex protein Nup214; nucleoporin Nup214", "tax_id": 10090, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119); brain disease (Disease Ontology:DOID:936); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:227720); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-450520); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 19, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21606357;21750661;22517741;22645316;23443134;25428506;25605945;26495903;27669760;29125738;29237092;30059200;31219806;32782141;32848054;33300544;34428180;34678516;34887587;35822049;36064721;36852467;39627609;39927985;40021952;40885482;40997131", "class_list": "", "function": "Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 76, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 76, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 76, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 83, "binding_glycan_count": 0, "secondary_ac_list": "A2ATN2", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:1990876 cytoplasmic side of nuclear pore", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0046822 regulation of nucleocytoplasmic transport;GO:0006611 protein export from nucleus;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 10.9, "record_id": "Q80U93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P5U7-1", "uniprot_id": "NWD2_MOUSE", "mass": 197414.0, "length": 1742, "protein_name": "NACHT and WD repeat domain-containing protein 2", "gene_name": "Nwd2", "organism": "Mouse", "refseq_name": "NACHT and WD repeat domain-containing protein 2", "refseq_ac": "NP_795980", "gene_names_uniprotkb": "Nwd2; 3110047P20Rik; Kiaa1239", "gene_names_refseq": "3110047P20Rik; B830017A01Rik; Hn1-ps2; Nwd2; mKIAA1239", "protein_names_uniprotkb": "NACHT and WD repeat domain-containing protein 2; Leucine-rich repeat and WD repeat-containing protein KIAA1239", "protein_names_refseq": "NACHT and WD repeat domain-containing protein 2; hematological and neurological expressed 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319807)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVW7;Q8CHA7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P5U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4F6-1", "uniprot_id": "NSUN5_MOUSE", "mass": 51030.0, "length": 465, "protein_name": "28S rRNA (cytosine-C(5))-methyltransferase", "gene_name": "Nsun5", "organism": "Mouse", "refseq_name": "28S rRNA (cytosine-C(5))-methyltransferase isoform 1", "refseq_ac": "NP_663389", "gene_names_uniprotkb": "Nsun5; Wbscr20a", "gene_names_refseq": "9830109N13Rik; Nol1r; Nsun5; Wbscr20a; Wbscr20", "protein_names_uniprotkb": "28S rRNA (cytosine-C(5))-methyltransferase; 2.1.1.-; NOL1/NOP2/Sun domain family member 5; Williams-Beuren syndrome chromosomal region 20A protein homolog", "protein_names_refseq": "28S rRNA (cytosine-C(5))-methyltransferase isoform 1; Williams Beuren syndrome chromosome region 20A homolog; Williams-Beuren syndrome critical region protein 20; probable 28S rRNA (cytosine-C(5))-methyltransferase; putative methyltransferase NSUN5; williams-Beuren syndrome chromosomal region 20A protein homolog", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:100609)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11978965;12073013;21750661;30485550;31174389;31219806;31462248;31722427;34428180;36210013;38670153;38712768", "class_list": "", "function": "Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage., [RefSeq, PubMed]; Mouse homologues of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome (WBSCR20; WBSCR22), [RefSeq, PubMed]; NSUN5 is essential for proper cell proliferation and differentiation of mouse preimplantation embryos. Publication Status: Online-Only, [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3438 (m5C3438) in 28S rRNA (PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (By similarity). Required for corpus callosum and cerebral cortex development (PubMed:31174389, PubMed:31462248)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0Q8;Q80WG3;Q8C568", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0050890 cognition;GO:0021987 cerebral cortex development;GO:0045727 positive regulation of translation;GO:0031641 regulation of myelination;GO:0014003 oligodendrocyte development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K4F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62092-1", "uniprot_id": "NSG1_MOUSE", "mass": 20929.0, "length": 185, "protein_name": "Neuronal vesicle trafficking-associated protein 1", "gene_name": "Nsg1", "organism": "Mouse", "refseq_name": "neuronal vesicle trafficking-associated protein 1", "refseq_ac": "NP_035072", "gene_names_uniprotkb": "Nsg1; NEEP21", "gene_names_refseq": "Neep21; Nsg1; m234; p21", "protein_names_uniprotkb": "Neuronal vesicle trafficking-associated protein 1; M234; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; p21", "protein_names_refseq": "brain neuron cytoplasmic protein 1; neuron-enriched endosomal protein of 21 kDa; neuron-specific protein family member 1; neuronal vesicle trafficking-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18196)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12070131;15187090;16037816;21084623;21750661;28299779;28874679;34428180;9013775;9461575", "class_list": "", "function": "Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:12070131, PubMed:15187090, PubMed:16037816, PubMed:21084623). Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:16037816). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54717;Q3UF63;Q922E5", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0032051 clathrin light chain binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0099627 neurotransmitter receptor cycle;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0006915 apoptotic process;GO:0042982 amyloid precursor protein metabolic process;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D720-1", "uniprot_id": "NSE1_MOUSE", "mass": 30708.0, "length": 266, "protein_name": "Non-structural maintenance of chromosomes element 1 homolog", "gene_name": "Nsmce1", "organism": "Mouse", "refseq_name": "non-structural maintenance of chromosomes element 1 homolog isoform 1", "refseq_ac": "NP_001363939", "gene_names_uniprotkb": "Nsmce1", "gene_names_refseq": "2510027N19Rik; Nsmce1", "protein_names_uniprotkb": "Non-structural maintenance of chromosomes element 1 homolog; 2.3.2.27; Non-SMC element 1 homolog", "protein_names_refseq": "non-SMC element 1 homolog; non-structural maintenance of chromosomes element 1 homolog isoform 1; non-structural maintenance of chromosomes element 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67711); (R-MMU-3108214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;31219806;31792732;34203471;34428180;36210013", "class_list": "", "function": "A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing., [RefSeq, PubMed]; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLN4;Q8K2B4;Q9CY20", "ec_number_list": "2.3.2.-;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046983 protein dimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:0097431 mitotic spindle pole;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U095-1", "uniprot_id": "NXPE2_MOUSE", "mass": 63966.0, "length": 558, "protein_name": "NXPE family member 2", "gene_name": "Nxpe2", "organism": "Mouse", "refseq_name": "NXPE family member 2 isoform 1", "refseq_ac": "NP_084345", "gene_names_uniprotkb": "Nxpe2; Fam55b", "gene_names_refseq": "4432416J03Rik; Fam55b; Nxpe2", "protein_names_uniprotkb": "NXPE family member 2; Protein FAM55B", "protein_names_refseq": "NXPE family member 2 isoform 1; NXPE family member 2; family with sequence similarity 55, member B; protein FAM55B", "tax_id": 10090, "disease": "", "pathway": " (mmu:78252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RU41;Q8BM95;Q9CX72", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U095-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CH40-1", "uniprot_id": "NUDT6_MOUSE", "mass": 35211.0, "length": 313, "protein_name": "Nudix hydrolase 6", "gene_name": "Nudt6", "organism": "Mouse", "refseq_name": "nudix hydrolase 6 isoform 2", "refseq_ac": "NP_705789", "gene_names_uniprotkb": "Nudt6; Asfgf2b", "gene_names_refseq": "Asfgf2b; Nudt6", "protein_names_uniprotkb": "Nudix hydrolase 6; 3.6.1.18; 3.6.1.22; Antisense basic fibroblast growth factor B; FAD diphosphatase NUDT6; NADH pyrophosphatase NUDT6; Nucleoside diphosphate-linked moiety X motif 6; Nudix motif 6", "protein_names_refseq": "FAD diphosphatase NUDT6; NADH pyrophosphatase NUDT6; antisense basic fibroblast growth factor B; nucleoside diphosphate-linked moiety X motif 6; nudix (nucleoside diphosphate linked moiety X)-type motif 6; nudix hydrolase 6 isoform 2; nudix motif 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:229228)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May contribute to the regulation of cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mediates the hydrolysis of some nucleoside diphosphate derivatives, such as NADH and FAD (in vitro). May modulate the subcellular levels of redox dinucleotides and control the mitochondrial concentrations of these compounds. May contribute to the regulation of cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULU4;Q8R2T3", "ec_number_list": "3.6.1.22;3.6.1.18;3.6.1.-;2.7.7.2", "go_molecular_function": "GO:0047631 ADP-ribose diphosphatase activity;GO:0051287 NAD binding;GO:0035529 NADH pyrophosphatase activity;GO:0047884 FAD diphosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005634 nucleus", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CH40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTK0-1", "uniprot_id": "NUPR1_MOUSE", "mass": 8901.0, "length": 80, "protein_name": "Nuclear protein 1", "gene_name": "Nupr1", "organism": "Mouse", "refseq_name": "nuclear protein 1", "refseq_ac": "NP_062712", "gene_names_uniprotkb": "Nupr1", "gene_names_refseq": "2310032H04Rik; Com1; Nupr1; p8", "protein_names_uniprotkb": "Nuclear protein 1; Protein p8", "protein_names_refseq": "nuclear protein 1; nuclear transcriptional regulator protein 1; protein p8", "tax_id": 10090, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457)", "pathway": " (mmu:56312)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11896600;16374777;18495683;19723804;20181828;21750661;22565310;23900510;27451286;38996786;39090667", "class_list": "", "function": "P8 is a growth inhibitor that facilitates apoptosis induced in fibroblasts by DNA damage, [RefSeq, PubMed]; Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress., [RefSeq, PubMed]; Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11896600, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:23900510, PubMed:27451286). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (By similarity). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (PubMed:11896600). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (By similarity). Coactivator of PAX2 transcription factor activity, both by recruiting the EP300 cofactor to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (By similarity). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (By similarity). Coordinates, through its interaction with EP300, the association of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (PubMed:23900510). Also required for LHB expression and ovarian maturation (PubMed:18495683). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (PubMed:16374777)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D756", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0045171 intercellular bridge", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:2000194 regulation of female gonad development;GO:1904691 negative regulation of type B pancreatic cell proliferation;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WTK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VU4-1", "uniprot_id": "NTF4_MOUSE", "mass": 22346.0, "length": 209, "protein_name": "Neurotrophin-4", "gene_name": "Ntf4; Ntf5", "organism": "Mouse", "refseq_name": "neurotrophin-4 preproprotein", "refseq_ac": "NP_937833", "gene_names_uniprotkb": "Ntf4; Ntf5; Ntf5", "gene_names_refseq": "2900040K06Rik; NT-4; NT-5; NT4/5; NT4; Ntf-5; Ntf4; Ntf5", "protein_names_uniprotkb": "Neurotrophin-4; NT-4; NT-5; Neurotrophin-5; Neutrophic factor 4", "protein_names_refseq": "neurotrophin-4 preproprotein; neurotrophin-4; neutrophic factor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:78405); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-9026527); (R-MMU-9028731)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "21750661;27015268;31392756;33932866", "class_list": "", "function": "Do BDNF and NT-4/5 exert synergistic or occlusive effects on corticostriatal transmission in a male mouse model of Huntington's disease?, [RefSeq, PubMed]; Neurotrophin-4 is essential for survival of the majority of vagal afferents to the mucosa of the small intestine, but not the stomach., [RefSeq, PubMed]; Target-derived survival factor for peripheral sensory sympathetic neurons (By similarity). May promote ameloblast differentiation and subsequent reduction in proliferation of ameloblasts (PubMed:27015268)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a secreted protein belonging to the neurotrophin family of structurally related molecules that play a crucial role in the control of neuronal numbers and of dendritic growth. The encoded preproprotein undergoes post-translational processing to generate non-covalently associated homodimeric functional protein. Mice deficient in the encoded protein exhibit a loss of sensory neurons in the nodose-petrosal and geniculate ganglia, have deficits in long-term memory and hippocampal long-lasting long-term potentiation. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80VU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55040-1", "uniprot_id": "NMUR1_MOUSE", "mass": 47934.0, "length": 428, "protein_name": "Neuromedin-U receptor 1", "gene_name": "Nmur1", "organism": "Mouse", "refseq_name": "neuromedin-U receptor 1 isoform 1", "refseq_ac": "NP_001306156", "gene_names_uniprotkb": "Nmur1; Gpr66", "gene_names_refseq": "FM-3; Gpr66; NMU-R1; NMU1R; NmU-R; Nmur1", "protein_names_uniprotkb": "Neuromedin-U receptor 1; G protein-coupled receptor 66; G protein-coupled receptor FM-3; NMU-R1; Neuromedin-U-1 receptor; NmU-1R", "protein_names_refseq": "G protein-coupled receptor 66; neuromedin-U receptor 1 isoform 1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14767); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "15585845;21750661;30084848;33857254;35820727;9782091", "class_list": "", "function": "G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (By similarity). Functionally, is involved in pleiotropic roles, including regulation of feeding, energy balance, blood pressure and smooth muscle contraction (By similarity). Additionally modulates hormone release and inflammatory responses in a tissue- and receptor-dependent manner (PubMed:15585845, PubMed:33857254). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling activatse a phospholipase C (PLC), hydrolyzing PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate) and mobilizing intracellular calcium via IP3 receptors on the endoplasmic reticulum. Also couples to GNAI1/Gai to inhibit forskolin-stimulated cAMP accumulation (By similarity). In pancreatic beta cells, through neuromedin U-25, regulates insulin secretion where it coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (PubMed:33857254). Through neuromedin U-25 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (PubMed:15585845)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, UniProtKB]; Receptor for the neuromedin-U and neuromedin-S neuropeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G5E871;Q0VB23", "ec_number_list": "", "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0001607 neuromedin U receptor activity;GO:0042924 neuromedin U binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007218 neuropeptide signaling pathway;GO:0019722 calcium-mediated signaling;GO:0050850 positive regulation of calcium-mediated signaling;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TL44-1", "uniprot_id": "NLRX1_MOUSE", "mass": 107831.0, "length": 975, "protein_name": "NLR family member X1", "gene_name": "Nlrx1", "organism": "Mouse", "refseq_name": "NLR family member X1", "refseq_ac": "NP_001157214", "gene_names_uniprotkb": "Nlrx1", "gene_names_refseq": "NOD9; Nlrx1", "protein_names_uniprotkb": "NLR family member X1", "protein_names_refseq": "NLR family member X1; nucleotide-binding domain and leucine-rich repeat containing", "tax_id": 10090, "disease": "", "pathway": " (mmu:270151); (R-MMU-936440); (R-MMU-9758274)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;20959452;21703539;21703540;21750661;25428506;30084848;30779550;33300544;34428180;35651602;37909827;38201227;38683455;39357547", "class_list": "", "function": "Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1., [RefSeq, PubMed]; NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy., [RefSeq, PubMed]; NLRX1 interacts with TRAF6 and inhibits NF-kappaB activation, [RefSeq, PubMed]; NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in antiviral signaling (PubMed:35651602). Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (By similarity). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (By similarity). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (By similarity). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (PubMed:35651602). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (PubMed:35651602)., [UniProtKB, UniProtKB, PubMed]; Study identifies a previously unrecognized role for NLRX1 in the negative regulation of TLR-induced NF-kappaB activation by dynamically interacting with TRAF6 and the IKK complex, [RefSeq, PubMed]; The presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKJ1;Q80W30;Q8C249", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0032688 negative regulation of interferon-beta production", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3TL44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34983-1", "uniprot_id": "O8G18_MOUSE", "mass": 35267.0, "length": 314, "protein_name": "Olfactory receptor 8G18", "gene_name": "Or8g18", "organism": "Mouse", "refseq_name": "olfactory receptor 8G18", "refseq_ac": "NP_997548", "gene_names_uniprotkb": "Or8g18; Olfr144; Olfr1537; Olfr7", "gene_names_refseq": "K4; MOR171-32P; MOR171-41P; Olfr144; Olfr1537-ps1; Olfr1537; Or8g18", "protein_names_uniprotkb": "Olfactory receptor 8G18; Odorant receptor K4; Olfactory receptor 144; Olfactory receptor 1537; Olfactory receptor 7B", "protein_names_refseq": "GA_x6K02T2PVTD-32935684-32934749; odorant receptor K4; olfactory receptor 144; olfactory receptor 1537, pseudogene 1; olfactory receptor 7B; olfactory receptor 8G18; olfactory receptor MOR171-32P; olfactory receptor MOR171-41P", "tax_id": 10090, "disease": "", "pathway": " (mmu:257959)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11130974;21750661;7683976", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TRB4;Q9EQA1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P34983-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08705-1", "uniprot_id": "NTCP_MOUSE", "mass": 39413.0, "length": 362, "protein_name": "Hepatic sodium/bile acid cotransporter", "gene_name": "Slc10a1", "organism": "Mouse", "refseq_name": "hepatic sodium/bile acid cotransporter isoform 2", "refseq_ac": "NP_035517", "gene_names_uniprotkb": "Slc10a1; Ntcp", "gene_names_refseq": "Ntcp; Slc10a1", "protein_names_uniprotkb": "Hepatic sodium/bile acid cotransporter; NTCP; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; SLC10A1; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1", "protein_names_refseq": "Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; hepatic sodium/bile acid cotransporter isoform 2; hepatic sodium/bile acid cotransporter; sodium bile acid cotransporting polypeptide; sodium-taurocholate cotransporting polypeptide", "tax_id": 10090, "disease": "familial hypercholanemia 2 (Disease Ontology:DOID:0061182); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20493); (R-MMU-159418)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10209268;17242355;21183079;21750661;31571363;32919083;34060352;34266968;34428180;37453647", "class_list": "", "function": "As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:10209268). It is strictly dependent on the extracellular presence of sodium (PubMed:10209268, PubMed:34060352). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:10209268, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings., [RefSeq, PubMed]; Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis., [RefSeq, PubMed]; Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35940;Q52L86", "ec_number_list": "", "go_molecular_function": "GO:0015125 bile acid transmembrane transporter activity;GO:0008508 bile acid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0045471 response to ethanol;GO:0015721 bile acid and bile salt transport;GO:0031667 response to nutrient levels;GO:0071466 cellular response to xenobiotic stimulus;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70310-1", "uniprot_id": "NTR2_MOUSE", "mass": 46376.0, "length": 416, "protein_name": "Neurotensin receptor type 2", "gene_name": "Ntsr2", "organism": "Mouse", "refseq_name": "neurotensin receptor type 2 isoform 1", "refseq_ac": "NP_032773", "gene_names_uniprotkb": "Ntsr2", "gene_names_refseq": "NT-R-2; NT2R; NTR2; NTRL; Ntsr2", "protein_names_uniprotkb": "Neurotensin receptor type 2; Low-affinity levocabastine-sensitive neurotensin receptor; NT-R-2; NTR2; NTRL", "protein_names_refseq": "low affinity neurotensin receptor; low-affinity levocabastine-sensitive neurotensin receptor; neurotensin receptor type 2 isoform 1; neurotensin receptor type 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18217); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11687289;11801734;21750661;29464190;8795617", "class_list": "", "function": "Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; Recycling ability depends on a single tyrosine residue, [RefSeq, PubMed]; Study shows that neurotensin receptor 2 expression remains constant throughout lifespan, and is predominantly expressed within glia. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulation; maps to chromosome 12, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIF5", "ec_number_list": "", "go_molecular_function": "GO:0016492 G protein-coupled neurotensin receptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043198 dendritic shaft;GO:0043204 perikaryon", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0042391 regulation of membrane potential;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q59J78-1", "uniprot_id": "NDUF2_MOUSE", "mass": 19628.0, "length": 168, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2", "gene_name": "Ndufaf2", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 isoform 1", "refseq_ac": "NP_001120818", "gene_names_uniprotkb": "Ndufaf2; Ndufa12l", "gene_names_refseq": "1810058I14Rik; Ndufa12l; Ndufaf2; mimitin", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; MMTN; Mimitin; Myc-induced mitochondrial protein; NDUFA12-like protein", "protein_names_refseq": "MMTN; Myc-induced mitochondria protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 isoform 1; NDUFA12-like protein; mimitin, mitochondrial; myc-induced mitochondrial protein", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 10 (Disease Ontology:DOID:0112075)", "pathway": " (mmu:75597); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15774466;21750661;22587331;23702311;32335026;32848054;34428180;36288343", "class_list": "", "function": "Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone., [UniProtKB, UniProtKB]; Mimitin overexpression increased basal and glucose-induced insulin secretion and prevented cytokine-mediated suppression of insulin secretion. Mimitin knockdown in MIN6 cells had opposite effects to those observed after overexpression., [RefSeq, PubMed]; NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4(-/-) mice and Leigh syndrome patients: A stabilizing role for NDUFAF2., [RefSeq, PubMed]; These data suggest that Ndufaf2, unlike other Complex-1 assembly factors, may be more accurately described as a chaperone involved in proper folding during Complex-1 assembly, since it is dispensable for Complex-1 maturation but not its proper function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q14A56;Q80VX9", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q59J78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70311-1", "uniprot_id": "NMT2_MOUSE", "mass": 60484.0, "length": 529, "protein_name": "Glycylpeptide N-tetradecanoyltransferase 2", "gene_name": "Nmt2", "organism": "Mouse", "refseq_name": "glycylpeptide N-tetradecanoyltransferase 2 isoform a", "refseq_ac": "NP_032734", "gene_names_uniprotkb": "Nmt2", "gene_names_refseq": "A930001K02Rik; Nmt2; hNMT-2", "protein_names_uniprotkb": "Glycylpeptide N-tetradecanoyltransferase 2; 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; Peptide N-myristoyltransferase 2; Type II N-myristoyltransferase", "protein_names_refseq": "glycylpeptide N-tetradecanoyltransferase 2 isoform a; glycylpeptide N-tetradecanoyltransferase 2; myristoyl-CoA:protein N-myristoyltransferase 2; peptide N-myristoyltransferase 2; type II N-myristoyltransferase", "tax_id": 10090, "disease": "muscular disease (Disease Ontology:DOID:0080000)", "pathway": " (mmu:18108); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16123142;21750661;22872234;34428180;9506952", "class_list": "", "function": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle., [UniProtKB, UniProtKB]; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins., [UniProtKB, UniProtKB, UniProtKB]; NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.97;3.6.5.-", "go_molecular_function": "GO:0004379 glycylpeptide N-tetradecanoyltransferase activity;GO:0018030 peptidyl-lysine N6-myristoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0018008 N-terminal peptidyl-glycine N-myristoylation;GO:0072657 protein localization to membrane;GO:0006499 N-terminal protein myristoylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H603-1", "uniprot_id": "NWD1_MOUSE", "mass": 173270.0, "length": 1563, "protein_name": "NACHT domain- and WD repeat-containing protein 1", "gene_name": "Nwd1", "organism": "Mouse", "refseq_name": "NACHT domain- and WD repeat-containing protein 1 isoform X2", "refseq_ac": "XP_006531150", "gene_names_uniprotkb": "Nwd1", "gene_names_refseq": "A230063L24Rik; Nwd1", "protein_names_uniprotkb": "NACHT domain- and WD repeat-containing protein 1", "protein_names_refseq": "NACHT domain- and WD repeat-containing protein 1 isoform X2", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547)", "pathway": " (mmu:319555)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "May play a role in the control of androgen receptor (AR) protein steady-state levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRC9;Q8BS99", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6H603-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHG1-1", "uniprot_id": "NRDC_MOUSE", "mass": 132891.0, "length": 1161, "protein_name": "Nardilysin", "gene_name": "Nrdc", "organism": "Mouse", "refseq_name": "nardilysin isoform 2 precursor", "refseq_ac": "NP_666262", "gene_names_uniprotkb": "Nrdc; Nrd1", "gene_names_refseq": "2600011I06Rik; NRD-C; Nrd1; Nrdc", "protein_names_uniprotkb": "Nardilysin; 3.4.24.61; N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase", "protein_names_refseq": "N-arginine dibasic convertase; NRD convertase; nardilysin isoform 2 precursor; nardilysin, N-arginine dibasic convertase, NRD convertase 1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:230598)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11478915;12054470;17242355;19131326;19935654;21183079;21750661;28017472;28135057;28528544;31219806;32683751;33642545;34418053;34428180;35236897;37507081;38605037;38648679;39627609", "class_list": "", "function": "Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination (PubMed:19935654). Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (PubMed:28017472)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels., [RefSeq, PubMed]; Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor., [RefSeq, PubMed]; Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics., [RefSeq, PubMed]; Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain., [RefSeq, PubMed]; The use of proteolysis to study the structure of nardilysin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030425 dendrite", "go_biological_process": "GO:0006508 proteolysis;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0032760 positive regulation of tumor necrosis factor production;GO:0050772 positive regulation of axonogenesis;GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8BHG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RXM4-1", "uniprot_id": "NTM1B_MOUSE", "mass": 32313.0, "length": 283, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 2", "gene_name": "Ntmt2", "organism": "Mouse", "refseq_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 2", "refseq_ac": "NP_001137428", "gene_names_uniprotkb": "Ntmt2; Mettl11b", "gene_names_refseq": "Gm207; Mettl11b; NTM1B; Ntmt2", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 2; 2.1.1.299; Alpha N-terminal protein methyltransferase 1B; Methyltransferase-like protein 11B; NTM1B; X-Pro-Lys N-terminal protein methyltransferase 1B", "protein_names_refseq": "N-terminal Xaa-Pro-Lys N-methyltransferase 2; X-Pro-Lys N-terminal protein methyltransferase 1B; alpha N-terminal protein methyltransferase 1B; methyltransferase like 11B; methyltransferase-like protein 11B", "tax_id": 10090, "disease": "", "pathway": " (mmu:240879)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.299", "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006480 N-terminal protein amino acid methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RXM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924S2-1", "uniprot_id": "OAS1C_MOUSE", "mass": 42912.0, "length": 362, "protein_name": "Inactive 2'-5' oligoadenylate synthetase 1C", "gene_name": "Oas1c", "organism": "Mouse", "refseq_name": "inactive 2'-5' oligoadenylate synthetase 1C", "refseq_ac": "NP_291019", "gene_names_uniprotkb": "Oas1c; Oasl5", "gene_names_refseq": "Oas1c; Oasl2; Oasl5", "protein_names_uniprotkb": "Inactive 2'-5' oligoadenylate synthetase 1C; 2',5'-oligoadenylate synthetase-like 5", "protein_names_refseq": "2',5'-oligoadenylate synthetase-like 5; 2'-5' oligoadenylate synthetase-like 2; inactive 2'-5' oligoadenylate synthetase 1C", "tax_id": 10090, "disease": "immunodeficiency 100 (Disease Ontology:DOID:0061070)", "pathway": " (mmu:114643)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11418248;12080145;21750661;27663720;34428180", "class_list": "", "function": "Does not have 2'-5'-OAS activity, but can bind double-stranded RNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0035457 cellular response to interferon-alpha;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q924S2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64311-1", "uniprot_id": "NTAN1_MOUSE", "mass": 34595.0, "length": 310, "protein_name": "Protein N-terminal asparagine amidohydrolase", "gene_name": "Ntan1", "organism": "Mouse", "refseq_name": "protein N-terminal asparagine amidohydrolase isoform 1", "refseq_ac": "NP_035076", "gene_names_uniprotkb": "Ntan1", "gene_names_refseq": "Ntan1; PNAA; PNAD", "protein_names_uniprotkb": "Protein N-terminal asparagine amidohydrolase; 3.5.1.121; PNAA; PNAD; Protein N-terminal Asn amidase; Protein NH2-terminal asparagine amidohydrolase; Protein NH2-terminal asparagine deamidase; Protein NTN-amidase", "protein_names_refseq": "asparagine-specific N-terminal amidase; protein N-terminal Asn amidase; protein N-terminal asparagine amidohydrolase isoform 1; protein N-terminal asparagine amidohydrolase; protein NH2-terminal asparagine amidohydrolase; protein NH2-terminal asparagine deamidase; protein NTN-amidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:18203)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16600435;21750661;8910481", "class_list": "", "function": "N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position., [UniProtKB, PubMed]; The protein encoded by this gene functions in a step-wise protein degradation process through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asparagine residues on proteins to produce N-terminal L-Aspartate. L-Aspartate substrates are subsequently conjugated to L-Arginine, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Mice with a knock-out of this gene are viable, fertile, and outwardly normal, but show impairments in spontaneous activity and spatial memory, relative to their wild-type counterparts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]; When embryonic 12-day-old or newborn mice were successively exposed to magnetic fields Ntan1 mRNA was significantly increased, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.121", "go_molecular_function": "GO:0008418 protein-N-terminal asparagine amidohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007613 memory;GO:0008344 adult locomotory behavior;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W63-1", "uniprot_id": "NRK1_MOUSE", "mass": 22303.0, "length": 195, "protein_name": "Nicotinamide riboside kinase 1", "gene_name": "Nmrk1", "organism": "Mouse", "refseq_name": "nicotinamide riboside kinase 1", "refseq_ac": "NP_663472", "gene_names_uniprotkb": "Nmrk1; BC016495; Nrk1", "gene_names_refseq": "D630020N23Rik; Nmrk1; Nrk1", "protein_names_uniprotkb": "Nicotinamide riboside kinase 1; 2.7.1.173; 2.7.1.22; NRK 1; Nicotinic acid riboside kinase 1; NmR-K 1; RNK 1; Ribosylnicotinamide kinase 1; Ribosylnicotinic acid kinase 1", "protein_names_refseq": "NRK 1; RNK 1; nicotinamide riboside kinase 1; nicotinic acid riboside kinase 1; nmR-K 1; ribosylnicotinamide kinase 1; ribosylnicotinic acid kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225994); (R-MMU-196807)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;27725675;28752046;29678570;36165811", "class_list": "", "function": "Adenoviral delivery of NRK1 in diet- and age-induced mice elevates hepatic NAD(+) levels, reduces hepatic steatosis, and improves glucose tolerance and insulin sensitivity., [RefSeq, PubMed]; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)., [UniProtKB, UniProtKB]; NRK1 KO myotubes revealed redundancy in the NRK1/2 dependent metabolism of nicotinamide riboside to NAD+. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous nicotinamide riboside and nicotinamide mononucleotide for NAD(+) synthesis. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic beta-cell failure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDW3", "ec_number_list": "2.7.1.173;2.7.1.22", "go_molecular_function": "GO:0050262 ribosylnicotinamide kinase activity;GO:0061769 nicotinate riboside kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91W63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZW2-1", "uniprot_id": "OFUT1_MOUSE", "mass": 44688.0, "length": 393, "protein_name": "GDP-fucose protein O-fucosyltransferase 1", "gene_name": "Pofut1", "organism": "Mouse", "refseq_name": "GDP-fucose protein O-fucosyltransferase 1 precursor", "refseq_ac": "NP_536711", "gene_names_uniprotkb": "Pofut1", "gene_names_refseq": "O-FucT-1; Pofut1", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 1; 2.4.1.221; O-FucT-1; Peptide-O-fucosyltransferase 1", "protein_names_refseq": "GDP-fucose protein O-fucosyltransferase 1 precursor; GDP-fucose protein O-fucosyltransferase 1; peptide-O-fucosyltransferase 1", "tax_id": 10090, "disease": "Dowling-Degos disease (Disease Ontology:DOID:0060256)", "pathway": " (mmu:140484)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11524432;12697902;18775496;19161597;21750661;26495903;30899004;34428180;36723873;37838775;38460791", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs)., [UniProtKB, PubMed, PubMed]; EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis., [RefSeq, PubMed]; Role of poFUT1 and O-fucosylation in placental angiogenesisdagger. Erratum:[Biol Reprod. 2026 Jan 11;114(1):338-339. doi: 10.1093/biolre/ioaf265. PMID: 41368789], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1R0;Q8C8R4", "ec_number_list": "2.4.1.221;2.4.1.-", "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0008417 fucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0007507 heart development;GO:0001756 somitogenesis", "synthesized_glycan_count": 158, "hit_score": 1.6, "record_id": "Q91ZW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35181-1", "uniprot_id": "NRG3_MOUSE", "mass": 77370.0, "length": 713, "protein_name": "Pro-neuregulin-3, membrane-bound isoform", "gene_name": "Nrg3", "organism": "Mouse", "refseq_name": "pro-neuregulin-3, membrane-bound isoform isoform 1", "refseq_ac": "NP_032760", "gene_names_uniprotkb": "Nrg3", "gene_names_refseq": "Nrg3; ska", "protein_names_uniprotkb": "Pro-neuregulin-3, membrane-bound isoform; Pro-NRG3", "protein_names_refseq": "pro-NRG3; pro-neuregulin-3, membrane-bound isoform isoform 1; scaramanga", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:18183); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1250342); (R-MMU-1250347); (R-MMU-1257604); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8863795)", "pathway_count": 14, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;9275162", "class_list": "", "function": "Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007416 synapse assembly;GO:0050804 modulation of chemical synaptic transmission;GO:2001223 negative regulation of neuron migration;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35181-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2F2-1", "uniprot_id": "OASL2_MOUSE", "mass": 58767.0, "length": 508, "protein_name": "2'-5'-oligoadenylate synthase-like protein 2", "gene_name": "Oasl2", "organism": "Mouse", "refseq_name": "2'-5'-oligoadenylate synthase-like protein 2 isoform 1", "refseq_ac": "NP_035984", "gene_names_uniprotkb": "Oasl2", "gene_names_refseq": "M1204; Mmu-OASL; Oasl2; Oasl", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase-like protein 2; 2.7.7.84; 54 kDa 2'-5'-oligoadenylate synthase-like protein; M1204; p54 OASL", "protein_names_refseq": "2'-5'-oligoadenylate synthase-like protein 2 isoform 1; 54 kDa 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthetase-like protein 2; p54 OASL", "tax_id": 10090, "disease": "", "pathway": " (mmu:23962)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10395668;12396720;12799444;17024523;21750661;34428180", "class_list": "", "function": "Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6S2", "ec_number_list": "2.7.7.84", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z2F2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641K5-1", "uniprot_id": "NUAK1_MOUSE", "mass": 73661.0, "length": 658, "protein_name": "NUAK family SNF1-like kinase 1", "gene_name": "Nuak1", "organism": "Mouse", "refseq_name": "NUAK family SNF1-like kinase 1", "refseq_ac": "NP_001004363", "gene_names_uniprotkb": "Nuak1; Kiaa0537; Omphk1", "gene_names_refseq": "B230104P22Rik; Nuak1; Omphk1", "protein_names_uniprotkb": "NUAK family SNF1-like kinase 1; 2.7.11.1; AMPK-related protein kinase 5; Omphalocele kinase 1", "protein_names_refseq": "AMPK-related protein kinase 5; NUAK family SNF1-like kinase 1; ZNUAK family, SNF1-like kinase, 1; omphalocele kinase 1", "tax_id": 10090, "disease": "uterine fibroid (Disease Ontology:DOID:13223)", "pathway": " (mmu:77976); (R-MMU-6804756)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16715502;21750661;22418434;34428180;35320001;36361872;38514619", "class_list": "", "function": "A physiological role of NUAK1 is to suppress glucose uptake through negative regulation of insulin signaling in oxidative muscle., [RefSeq, PubMed]; Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte Synergistically Promote Liver Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; NUAK1 promotes organ fibrosis via YAP and TGF-beta/SMAD signaling., [RefSeq, PubMed]; Omphk1 expression is also found in each tissue associated with the ventral body wall closure: the primary body wall composed of primitive ectoderm and each component of the secondary body wall [Omphk1], [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair., [UniProtKB, UniProtKB]; The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6I6D6;Q8CGE1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0002039 p53 binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007155 cell adhesion;GO:0030155 regulation of cell adhesion;GO:0006974 DNA damage response;GO:2000772 regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q641K5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI93-1", "uniprot_id": "OAS3_MOUSE", "mass": 126333.0, "length": 1138, "protein_name": "2'-5'-oligoadenylate synthase 3", "gene_name": "Oas3", "organism": "Mouse", "refseq_name": "2'-5'-oligoadenylate synthase 3", "refseq_ac": "NP_660261", "gene_names_uniprotkb": "Oas3; oasl10", "gene_names_refseq": "Oas3; Oasl10", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase 3; (2-5')oligo(A) synthase 3; 2',5'-oligoadenylate synthetase-like 10; 2-5A synthase 3; 2.7.7.84", "protein_names_refseq": "(2-5')oligo(A) synthase 3; 2',5'-oligoadenylate synthetase-like 10; 2'-5'-oligoadenylate synthase 3; 2-5A synthase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:246727)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12080145;12396720;17024523;21142819;21750661;34428180", "class_list": "", "function": "Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EIU4;Q8K4D2", "ec_number_list": "2.7.7.84", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VI93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWD8-1", "uniprot_id": "NUBPL_MOUSE", "mass": 34139.0, "length": 319, "protein_name": "Iron-sulfur cluster transfer protein NUBPL", "gene_name": "Nubpl", "organism": "Mouse", "refseq_name": "iron-sulfur cluster transfer protein NUBPL precursor", "refseq_ac": "NP_084036", "gene_names_uniprotkb": "Nubpl", "gene_names_refseq": "2410170E07Rik; Nubpl", "protein_names_uniprotkb": "Iron-sulfur cluster transfer protein NUBPL; Nucleotide-binding protein-like", "protein_names_refseq": "iron-sulfur cluster transfer protein NUBPL precursor; iron-sulfur cluster transfer protein NUBPL; iron-sulfur protein NUBPL", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 21 (Disease Ontology:DOID:0112088)", "pathway": " (mmu:76826); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;34428180;35820727", "class_list": "", "function": "Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (By similarity). May deliver one or more Fe-S clusters to complex I subunits (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6K2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CWD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35980-1", "uniprot_id": "NTH_MOUSE", "mass": 33637.0, "length": 300, "protein_name": "Endonuclease III-like protein 1", "gene_name": "Nthl1", "organism": "Mouse", "refseq_name": "endonuclease III-like protein 1 isoform 1", "refseq_ac": "NP_032769", "gene_names_uniprotkb": "Nthl1; Nth1", "gene_names_refseq": "Nth1; Nthl1; Octs3", "protein_names_uniprotkb": "Endonuclease III-like protein 1; 3.2.2.-; 4.2.99.18; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycosylase/AP lyase", "protein_names_refseq": "DNA glycoslyase/AP lyase; bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; endonuclease III-like protein 1 isoform 1; endonuclease III-like protein 1; thymine glycol DNA glycosylase/AP lyase", "tax_id": 10090, "disease": "familial adenomatous polyposis 3 (Disease Ontology:DOID:0080411)", "pathway": " (mmu:18207); (R-MMU-110329); (R-MMU-110357)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12093749;12167705;12531031;23874233;23984319;31219806;34428180;34826736;9743625", "class_list": "", "function": "Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines., [UniProtKB, PubMed, HAMAP]; Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability., [RefSeq, PubMed]; These results suggest that Nth1 plays an important role in telomere maintenance and base repair against oxidative stress-induced base modifications., [RefSeq, PubMed]; To determine the role of murine Nth1 in protecting genomic integrity, a knockout strain was created. No phenotypic changes from wild type were noted due to a novel AP endonuclease DNA repair system., [RefSeq, PubMed]; To determine the significance of thymine glycol repair in mammals, a mouse model with mutated mNth1, a homolog of nth, was made by gene targeting. Mutant mouse liver, instead of mNTH1 activity, had at least 2 novel DNA glycosylase activities against Tg. Erratum:[EMBO J 2002 Aug 15;21(16):4391. Sarker Altraf H [corrected to Sarker Altaf H]], [RefSeq, PubMed]; Toxicity, induced by tert-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (+/+), Nth1 (+/+)) and deficient (Mpg (-/-), Nth1 (-/-)) mouse embryonic fibroblasts following Msh2 knockdown, was examined., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMW1", "ec_number_list": "4.2.99.18;3.2.2.-;1.14.11.51;1.14.11.-;1.14.11.33;5.6.2.4;3.1.11.2;3.1.21.-;2.7.7.7;4.2.99.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0006289 nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35980-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88319-1", "uniprot_id": "NTR1_MOUSE", "mass": 47217.0, "length": 424, "protein_name": "Neurotensin receptor type 1", "gene_name": "Ntsr1", "organism": "Mouse", "refseq_name": "neurotensin receptor type 1", "refseq_ac": "NP_061236", "gene_names_uniprotkb": "Ntsr1; Ntsr", "gene_names_refseq": "NT-1R; NTR-1; NTR1; Ntsr1", "protein_names_uniprotkb": "Neurotensin receptor type 1; NT-R-1; NTR1", "protein_names_refseq": "NT-R-1; neurotensin receptor type 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinson's disease (Disease Ontology:DOID:14330); opiate dependence (Disease Ontology:DOID:2559); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:18216); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "25428506;39927985", "class_list": "", "function": "G protein-coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016492 G protein-coupled neurotensin receptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0001659 temperature homeostasis;GO:0006171 cAMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88319-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C027-1", "uniprot_id": "NUD10_MOUSE", "mass": 18593.0, "length": 164, "protein_name": "Diphosphoinositol polyphosphate phosphohydrolase 3-alpha", "gene_name": "Nudt10", "organism": "Mouse", "refseq_name": "diphosphoinositol polyphosphate phosphohydrolase 3-alpha", "refseq_ac": "NP_001026834", "gene_names_uniprotkb": "Nudt10; Dipp3a", "gene_names_refseq": "DIPP3-alpha; DIPP3-beta; Dipp3a; Dipp3b; Nudt10; Nudt11", "protein_names_uniprotkb": "Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; 3.6.1.52; 3.6.1.60; DIPP-3-alpha; DIPP3-alpha; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha; Diadenosine hexaphosphate hydrolase (AMP-forming); Nucleoside diphosphate-linked moiety X motif 10; Nudix motif 10", "protein_names_refseq": "DIPP3 alpha; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta; Diphosphoinositol polyphosphate phosphohydrolase 3-beta; Nucleoside diphosphate-linked moiety X motif 11; Nudix motif 11; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha; diadenosine hexaphosphate hydrolase (AMP-forming); diphosphoinositol polyphosphate phosphohydrolase 3-alpha; nucleoside diphosphate-linked moiety X motif 10; nudix (nucleoside diphosphate linked moiety X)-type motif 10; nudix motif 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:102954); (mmu:58242); (R-MMU-1855167)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12689335;15345747;35820727", "class_list": "", "function": "Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear., [UniProtKB]; High levels are expressed in liver, kidney and testis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKF4", "ec_number_list": "3.6.1.52;3.6.1.60;3.6.1.-;3.1.4.1;3.6.1.9;3.6.1.61;3.6.1.59;3.6.1.62;3.6.1.10", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C027-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C028-1", "uniprot_id": "NUD11_MOUSE", "mass": 18593.0, "length": 164, "protein_name": "Diphosphoinositol polyphosphate phosphohydrolase 3-beta", "gene_name": "Nudt11", "organism": "Mouse", "refseq_name": "diphosphoinositol polyphosphate phosphohydrolase 3-beta", "refseq_ac": "NP_067406", "gene_names_uniprotkb": "Nudt11; Dipp3b; MNCb-1696", "gene_names_refseq": "DIPP3b; DIPP3; Dipp3a; Nudt10; Nudt11", "protein_names_uniprotkb": "Diphosphoinositol polyphosphate phosphohydrolase 3-beta; 3.6.1.52; 3.6.1.60; DIPP-3-beta; DIPP3-beta; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta; Diadenosine hexaphosphate hydrolase (AMP-forming); Nucleoside diphosphate-linked moiety X motif 11; Nudix motif 11", "protein_names_refseq": "DIPP-3-alpha; DIPP-3-beta; DIPP3-alpha; DIPP3-beta; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha; Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Nucleoside diphosphate-linked moiety X motif 10; Nudix motif 10; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta; diadenosine hexaphosphate hydrolase (AMP-forming); diphosphoinositol polyphosphate phosphohydrolase 3-beta; nucleoside diphosphate-linked moiety X motif 11; nudix (nucleoside diphosphate linked moiety X)-type motif 11; nudix motif 11; nudix-type motif 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:102954); (mmu:58242); (R-MMU-1855167)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12689335;15345747", "class_list": "", "function": "Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear., [UniProtKB]; High levels are expressed primarily in brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKF4;Q9JJD3", "ec_number_list": "3.6.1.52;3.6.1.60;3.6.1.-;3.1.4.1;3.6.1.9;3.6.1.61;3.6.1.59;3.6.1.62;3.6.1.10", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32507-1", "uniprot_id": "NECT2_MOUSE", "mass": 57318.0, "length": 530, "protein_name": "Nectin-2", "gene_name": "Nectin2", "organism": "Mouse", "refseq_name": "nectin-2 isoform 2 precursor", "refseq_ac": "NP_001153196", "gene_names_uniprotkb": "Nectin2; Mph; Pvrl2; Pvr; Pvs", "gene_names_refseq": "Cd112; MPH; Nectin2; Pvrl2; Pvr; Pvs; nectin-2", "protein_names_uniprotkb": "Nectin-2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Murine herpes virus entry protein B; Nectin cell adhesion molecule 2; Poliovirus receptor homolog; Poliovirus receptor-related protein 2; mHveB", "protein_names_refseq": "herpes virus entry mediator B; herpesvirus entry mediator B; hveB; mHveB; murine herpes virus entry protein B; murine herpesvirus entry protein B; nectin-2 isoform 2 precursor; poliovirus receptor homolog; poliovirus receptor-related 2; poliovirus receptor-related protein 2; poliovirus sensitivity", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:19294); (R-MMU-198933); (R-MMU-418990); (R-MMU-420597)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10196354;10744716;1560525;19349973;21183079;22902367;26495903;32452538;33467729;8132569", "class_list": "", "function": "CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. Publication Status: Online-Only, [RefSeq, PubMed]; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein., [UniProtKB, UniProtKB]; Nectin-2alpha is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62096", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0016020 membrane;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0030382 sperm mitochondrion organization;GO:0046814 coreceptor-mediated virion attachment to host cell;GO:0044406 adhesion of symbiont to host;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43021-1", "uniprot_id": "NODAL_MOUSE", "mass": 40476.0, "length": 354, "protein_name": "Nodal", "gene_name": "Nodal", "organism": "Mouse", "refseq_name": "nodal preproprotein", "refseq_ac": "NP_038639", "gene_names_uniprotkb": "Nodal", "gene_names_refseq": "Nodal; Tg.413d", "protein_names_uniprotkb": "Nodal", "protein_names_refseq": "nodal preproprotein", "tax_id": 10090, "disease": "anxiety disorder (Disease Ontology:DOID:2030); visceral heterotaxy 5 (Disease Ontology:DOID:758); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:18119)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8429908;8582278", "class_list": "glycogene", "function": "Essential for mesoderm formation and axial patterning during embryonic development., [UniProtKB, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH87", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity;GO:0070698 type I activin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0022409 positive regulation of cell-cell adhesion;GO:0001842 neural fold formation;GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0048729 tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43021-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47759-1", "uniprot_id": "NSG2_MOUSE", "mass": 19000.0, "length": 171, "protein_name": "Neuronal vesicle trafficking-associated protein 2", "gene_name": "Nsg2", "organism": "Mouse", "refseq_name": "neuronal vesicle trafficking-associated protein 2 isoform 1", "refseq_ac": "NP_001277609", "gene_names_uniprotkb": "Nsg2", "gene_names_refseq": "Nsg2; P19", "protein_names_uniprotkb": "Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2; Protein 8.5; Protein p19", "protein_names_refseq": "neuron-specific protein family member 2; neuronal vesicle trafficking-associated protein 2 isoform 1; neuronal vesicle trafficking-associated protein 2; protein 8.5; protein p19", "tax_id": 10090, "disease": "", "pathway": " (mmu:18197)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;28299779;28874679;30680309;7829526", "class_list": "", "function": "NSG2 is found in discrete punctae restricted to the somatodendritic arbors of developing mouse and human neurons, and a significant proportion of NSG2 punctae colocalize with postsynaptic HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs) at excitatory synapses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:1990674 Golgi cis cisterna membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0016197 endosomal transport;GO:0048268 clathrin coat assembly;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63056-1", "uniprot_id": "NOE3_MOUSE", "mass": 54886.0, "length": 478, "protein_name": "Noelin-3", "gene_name": "Olfm3", "organism": "Mouse", "refseq_name": "noelin-3 isoform B precursor", "refseq_ac": "NP_694797", "gene_names_uniprotkb": "Olfm3; Noe3", "gene_names_refseq": "B230206G02Rik; Olfm3", "protein_names_uniprotkb": "Noelin-3; Olfactomedin-3; Optimedin", "protein_names_refseq": "noelin-3 isoform B precursor; noelin-3; optimedin", "tax_id": 10090, "disease": "", "pathway": " (mmu:229759)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12019210;16115881;21228389;21750661;22632720;33300544;34418053", "class_list": "", "function": "Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKV2;Q8BLL6;Q8QZW0;Q8R4K3;Q8R4K4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0007165 signal transduction;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P63056-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97503-1", "uniprot_id": "NKX32_MOUSE", "mass": 35167.0, "length": 333, "protein_name": "Homeobox protein Nkx-3.2", "gene_name": "Nkx3-2", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-3.2", "refseq_ac": "NP_031550", "gene_names_uniprotkb": "Nkx3-2; Bapx1; Nkx-3.2; Nkx3b", "gene_names_refseq": "Bapx1; NKX3.2; Nkx-3.2; Nkx3-2", "protein_names_uniprotkb": "Homeobox protein Nkx-3.2; Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B", "protein_names_refseq": "bagpipe homeobox gene 1 homolog; bagpipe homeobox protein homolog 1; homeobox protein NK-3 homolog B; homeobox protein Nkx-3.2; homeodomain protein Nkx-3.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12020)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14973294;16421188;19208343;31219806;9256352", "class_list": "", "function": "Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6G9", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07475-1", "uniprot_id": "NREP_MOUSE", "mass": 7688.0, "length": 68, "protein_name": "Neuronal regeneration-related protein", "gene_name": "Nrep", "organism": "Mouse", "refseq_name": "neuronal regeneration-related protein", "refseq_ac": "NP_001103458", "gene_names_uniprotkb": "Nrep; D0H4S114; P311", "gene_names_refseq": "D0H4S114; Harp; Nrep; P311; PTZ17; SEZ17", "protein_names_uniprotkb": "Neuronal regeneration-related protein; Neuronal protein 3.1; Protein p311", "protein_names_refseq": "high-altitude regulated protein; neuronal protein 3.1; neuronal regeneration-related protein; protein p311", "tax_id": 10090, "disease": "", "pathway": " (mmu:27528)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12417574;14985127;16484684;16934802;18549486;18616608;18664493;32539181;32682987;8261136", "class_list": "", "function": "Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-beta1 pathway., [RefSeq, PubMed]; May have roles in cellular differentiation. Ectopic expression induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. May also have neural functions. Promotes axonal regeneration and augments motility of gliomas. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; P311 regulates distal lung development via its interaction with several binding proteins., [RefSeq, PubMed]; Role for P311 in inducing TGF-beta1-independent myofibroblast transformation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0045664 regulation of neuron differentiation;GO:0031103 axon regeneration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q07475-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14AW5-1", "uniprot_id": "NSUN7_MOUSE", "mass": 81968.0, "length": 724, "protein_name": "Protein NSUN7", "gene_name": "Nsun7", "organism": "Mouse", "refseq_name": "putative methyltransferase NSUN7 isoform 1", "refseq_ac": "NP_001289762", "gene_names_uniprotkb": "Nsun7", "gene_names_refseq": "4921525L17Rik; Nsun7", "protein_names_uniprotkb": "Protein NSUN7; NOL1/NOP2/Sun domain family member 7", "protein_names_refseq": "putative methyltransferase NSUN7 isoform 1; putative methyltransferase NSUN7", "tax_id": 10090, "disease": "", "pathway": " (mmu:70918)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17442852;21750661;34418053;41381527", "class_list": "", "function": "Plays an essential for sperm flagellum assembly., [UniProtKB, PubMed]; Sun domain containing protein Nsun7 mutant sperm exhibited depressed progressive motility associated with a rigid flagellar midpiece (but not principal piece) segment, [RefSeq, PubMed]; This gene encodes a member of the NOL1/NOP2/sun domain RNA methyltransferase family. Mice with a mutation in this gene exhibit male sterility due to impaired sperm motility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS48;Q9D5S9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0030317 flagellated sperm motility;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q14AW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHB1-1", "uniprot_id": "NT5D3_MOUSE", "mass": 63170.0, "length": 546, "protein_name": "5'-nucleotidase domain-containing protein 3", "gene_name": "Nt5dc3", "organism": "Mouse", "refseq_name": "5'-nucleotidase domain-containing protein 3", "refseq_ac": "NP_780540", "gene_names_uniprotkb": "Nt5dc3; Gnn", "gene_names_refseq": "C630002B14Rik; Nt5dc3; TU12B1-TY", "protein_names_uniprotkb": "5'-nucleotidase domain-containing protein 3; 3.1.3.-; GRP94-neighboring nucleotidase", "protein_names_refseq": "5'-nucleotidase domain-containing protein 3; TU12B1-TY protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:103466)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9W5", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043235 receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UHB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0C3-1", "uniprot_id": "NUTM2_MOUSE", "mass": 80589.0, "length": 733, "protein_name": "NUT family member 2", "gene_name": "Nutm2", "organism": "Mouse", "refseq_name": "NUT family member 2", "refseq_ac": "NP_001028572", "gene_names_uniprotkb": "Nutm2; Gm806", "gene_names_refseq": "Fam22; Gm806; Nutm2", "protein_names_uniprotkb": "NUT family member 2", "protein_names_refseq": "NUT family member 2; NUT family member Gm806; protein FAM22", "tax_id": 10090, "disease": "", "pathway": " (mmu:328250)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;29237092", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3V0C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497P3-1", "uniprot_id": "NUPR2_MOUSE", "mass": 11767.0, "length": 102, "protein_name": "Nuclear protein 2", "gene_name": "Nupr2", "organism": "Mouse", "refseq_name": "nuclear protein 2", "refseq_ac": "NP_081192", "gene_names_uniprotkb": "Nupr2; Nupr1l", "gene_names_refseq": "1810010E01Rik; 4930579G22Rik; Nupr1l; Nupr2", "protein_names_uniprotkb": "Nuclear protein 2; Nuclear transcriptional regulator 1-like protein; Nuclear transcriptional regulator protein 2", "protein_names_refseq": "nuclear protein 2; nuclear protein transcriptional regulator 1 like; nuclear transcriptional regulator 1-like protein; nuclear transcriptional regulator protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation of pancreatic cancer cells. Plays a role as a negative regulator of the protumoral factor NUPR1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXQ0;Q9D923", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q497P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q52KP5-1", "uniprot_id": "NXPE4_MOUSE", "mass": 61551.0, "length": 543, "protein_name": "NXPE family member 4", "gene_name": "Nxpe4", "organism": "Mouse", "refseq_name": "NXPE family member 4", "refseq_ac": "NP_766509", "gene_names_uniprotkb": "Nxpe4; Fam55d", "gene_names_refseq": "C130036J11; D930028F11Rik; Fam55d; Nxpe4", "protein_names_uniprotkb": "NXPE family member 4; Protein FAM55D", "protein_names_refseq": "NXPE family member 4; family with sequence similarity 55, member D; protein FAM55D", "tax_id": 10090, "disease": "", "pathway": " (mmu:244853)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGS9;Q8BKY4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q52KP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTZ0-1", "uniprot_id": "NYNRI_MOUSE", "mass": 203068.0, "length": 1840, "protein_name": "Protein NYNRIN", "gene_name": "Nynrin", "organism": "Mouse", "refseq_name": "protein NYNRIN", "refseq_ac": "NP_001035161", "gene_names_uniprotkb": "Nynrin; Kiaa1305", "gene_names_refseq": "Nynrin; mKIAA1305", "protein_names_uniprotkb": "Protein NYNRIN; NYN domain and retroviral integrase catalytic domain-containing protein; Pol-like protein", "protein_names_refseq": "NYN domain and retroviral integrase catalytic domain-containing protein; pol-like protein; protein NYNRIN", "tax_id": 10090, "disease": "", "pathway": " (mmu:277154)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16155747;20173027;21750661;34203471;34428180;36210013;40885482", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9EKP9;Q32KG8;Q3V1I3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0015074 DNA integration;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5DTZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F2E7-1", "uniprot_id": "NUFP2_MOUSE", "mass": 75657.0, "length": 692, "protein_name": "FMR1-interacting protein NUFIP2", "gene_name": "Nufip2", "organism": "Mouse", "refseq_name": "FMR1-interacting protein NUFIP2", "refseq_ac": "NP_001019376", "gene_names_uniprotkb": "Nufip2; Kiaa1321", "gene_names_refseq": "1110001M19Rik; 9530056D24Rik; Nufip2; PIG1; mKIAA1321", "protein_names_uniprotkb": "FMR1-interacting protein NUFIP2; 82 kDa FMRP-interacting protein; 82-FIP; FMRP-interacting protein 2", "protein_names_refseq": "82 kDa FMRP-interacting protein; 82-FIP; FMR1-interacting protein NUFIP2; FMRP-interacting protein 2; proliferation-inducing gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68564)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12837692;15345747;17114649;17242355;19131326;19144319;21183079;22517741;22645316;25428506;29352114;30779550;32782141;32848054;34887587;36852467;40885482;40997131", "class_list": "", "function": "Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Binds RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCE2;Q3V195;Q80TF1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q5F2E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M8M2-1", "uniprot_id": "CMA1B_MOUSE", "mass": 25923.0, "length": 238, "protein_name": "Ciliary microtubule associated protein 1B", "gene_name": "Cimap1b", "organism": "Mouse", "refseq_name": "ciliary microtubule associated protein 1B isoform 1", "refseq_ac": "NP_001013040", "gene_names_uniprotkb": "Cimap1b; Odf3b; Odf3l3", "gene_names_refseq": "2010001J22Rik; Cimap1b; Odf3b", "protein_names_uniprotkb": "Ciliary microtubule associated protein 1B; Outer dense fiber protein 3-like protein 3; Outer dense fiber protein 3B", "protein_names_refseq": "ciliary microtubule associated protein 1B isoform 1; outer dense fiber of sperm tails 3B; outer dense fiber protein 3-like protein 3; outer dense fiber protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:70113)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0031514 motile cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M8M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PT53-1", "uniprot_id": "NTCP7_MOUSE", "mass": 37256.0, "length": 340, "protein_name": "Sodium/bile acid cotransporter 7", "gene_name": "Slc10a7", "organism": "Mouse", "refseq_name": "sodium/bile acid cotransporter 7 isoform c", "refseq_ac": "NP_001009981", "gene_names_uniprotkb": "Slc10a7; P7", "gene_names_refseq": "2410193C02Rik; P7; Slc10a7", "protein_names_uniprotkb": "Sodium/bile acid cotransporter 7; Na(+)/bile acid cotransporter 7; Solute carrier family 10 member 7", "protein_names_refseq": "Na(+)/bile acid cotransporter 7; sodium/bile acid cotransporter 7 isoform c", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:76775)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17628207;21750661;30082715;31191616", "class_list": "", "function": "Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715). Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate)., [UniProtKB, PubMed, UniProtKB]; Molecular characterization and expression analysis of a novel member of the SLC10 family, SLC10A7, previously known as C4orf13, is reported, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PT51;Q8BV58;Q8BYD0;Q9CWD6", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060348 bone development;GO:0006814 sodium ion transport;GO:0030210 heparin proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5PT53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60856-1", "uniprot_id": "OAS1B_MOUSE", "mass": 43620.0, "length": 376, "protein_name": "Inactive 2'-5'-oligoadenylate synthase 1B", "gene_name": "Oas1b", "organism": "Mouse", "refseq_name": "inactive 2'-5'-oligoadenylate synthase 1B", "refseq_ac": "NP_001077394", "gene_names_uniprotkb": "Oas1b; Flv; Oias2", "gene_names_refseq": "Flv; L1; Mmu-L1; Oas1b; Oas1; Oias-2; Oias2; Wnv", "protein_names_uniprotkb": "Inactive 2'-5'-oligoadenylate synthase 1B; (2-5')oligo(A) synthase 1B; 2'-5'-oligoadenylate synthase-like protein 1; 2-5A synthase 1B", "protein_names_refseq": "(2-5')oligo(A) synthase 1B; (2-5')oligo(A) synthetase 1b; 2'-5'-oligoadenylate synthase-like protein 1; 2'-5'-oligoadenylate synthetase-like protein 1; 2-5A synthase 1B; 2-5A synthetase 1B; Flavivirus resistance; inactive 2'-5'-oligoadenylate synthase 1B", "tax_id": 10090, "disease": "immunodeficiency 100 (Disease Ontology:DOID:0061070)", "pathway": " (mmu:23961)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12080145;12186974;12396720;16371364;17024523;1709495;17904183;18460447;22305621;22623793;27663720;31413116;34428180;38423012", "class_list": "", "function": "A nonsense mutation in the gene is associated with West Nile virus susceptibility in laboratory mice, [RefSeq, PubMed]; Characterization of ABCF3 protein and its interaction with OAS1B, [RefSeq, PubMed]; Does not have 2'-5'-OAS activity, but can bind double-stranded RNA (PubMed:12396720, PubMed:27663720). The full-length protein displays antiviral activity against flaviviruses such as west Nile virus (WNV) via an alternative antiviral pathway independent of RNase L (PubMed:12080145, PubMed:16371364, PubMed:17904183, PubMed:27663720). The truncated form of the protein lacks antiviral activity (PubMed:12080145, PubMed:16371364, PubMed:17904183)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production., [RefSeq, PubMed]; This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8YPE5;A8YPE7;A8YPE8;A8YPE9;E9QKP6;Q78ZX0;Q8JZN0;Q8JZN4;Q8VI98", "ec_number_list": "", "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0035457 cellular response to interferon-alpha;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q60856-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61199-1", "uniprot_id": "NXPH2_MOUSE", "mass": 29975.0, "length": 261, "protein_name": "Neurexophilin-2", "gene_name": "Nxph2", "organism": "Mouse", "refseq_name": "neurexophilin-2 precursor", "refseq_ac": "NP_032778", "gene_names_uniprotkb": "Nxph2; Nph2", "gene_names_refseq": "Nxph2", "protein_names_uniprotkb": "Neurexophilin-2", "protein_names_refseq": "neurexophilin-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18232)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;20202923;8699246", "class_list": "", "function": "May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors., [UniProtKB]; NXPH2 is 200 kb upstream of SNP rs10803574 that has been associated with alcoholism in two human cohorts (p <10e-6) and is a strong positional candidate., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9234, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIN8", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61200-1", "uniprot_id": "NXPH1_MOUSE", "mass": 31048.0, "length": 271, "protein_name": "Neurexophilin-1", "gene_name": "Nxph1", "organism": "Mouse", "refseq_name": "neurexophilin-1 precursor", "refseq_ac": "NP_032777", "gene_names_uniprotkb": "Nxph1; Nph1", "gene_names_refseq": "C130005L03Rik; Nxph1", "protein_names_uniprotkb": "Neurexophilin-1", "protein_names_refseq": "neurexophilin-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18231)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12141453;30899004;8699246", "class_list": "", "function": "May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins., [UniProtKB]; Study on the expression of NXPH1 in the developing and adult olfactory bulb, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A6H6P7;Q8BHJ2;Q8BLP4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61999-1", "uniprot_id": "ODFP1_MOUSE", "mass": 27539.0, "length": 247, "protein_name": "Outer dense fiber protein 1", "gene_name": "Odf1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Odf1; Odfp", "gene_names_refseq": "", "protein_names_uniprotkb": "Outer dense fiber protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "31475146;39386799;7789171", "class_list": "", "function": "Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005813 centrosome;GO:0036126 sperm flagellum;GO:0002177 manchette", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66X01-1", "uniprot_id": "NLR9C_MOUSE", "mass": 115722.0, "length": 1004, "protein_name": "NACHT, LRR and PYD domains-containing protein 9C", "gene_name": "Nlrp9c", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 9C", "refseq_ac": "NP_001036077", "gene_names_uniprotkb": "Nlrp9c; Nalp9c", "gene_names_refseq": "Nalp-zeta; Nalp9c; Nlrp9c", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 9C; NALP-zeta", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 9C", "tax_id": 10090, "disease": "", "pathway": " (mmu:330490)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15317747", "class_list": "", "function": "May be involved in inflammation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULL8;Q6UTW8", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050727 regulation of inflammatory response;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66X01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PIP5-1", "uniprot_id": "NUDC1_MOUSE", "mass": 66705.0, "length": 582, "protein_name": "NudC domain-containing protein 1", "gene_name": "Nudcd1", "organism": "Mouse", "refseq_name": "nudC domain-containing protein 1 isoform 2", "refseq_ac": "NP_001107026", "gene_names_uniprotkb": "Nudcd1", "gene_names_refseq": "4921532K09Rik; CML66-L; Cml66; Nudcd1", "protein_names_uniprotkb": "NudC domain-containing protein 1", "protein_names_refseq": "chronic myelogenous leukemia tumor antigen 66; nudC domain-containing protein 1 isoform 2; nudC domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67429)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14688378;21750661;24633332;25605945;28528544", "class_list": "", "function": "Results indicate that OVA66 is important in oncogenic transformation, promoting proliferation, cell migration and reducing apoptosis via hyperactivating PI3K/AKT and ERK1/2 MAPK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THV3;Q71EC1;Q8BJZ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PIP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YV2-1", "uniprot_id": "ZC3C1_MOUSE", "mass": 55196.0, "length": 501, "protein_name": "Zinc finger C3HC-type protein 1", "gene_name": "Zc3hc1", "organism": "Mouse", "refseq_name": "zinc finger C3HC-type protein 1 isoform 1", "refseq_ac": "NP_001298015", "gene_names_uniprotkb": "Zc3hc1; Nipa", "gene_names_refseq": "1110054L24Rik; HSPC216; Nipa; Zc3hc1", "protein_names_uniprotkb": "Zinc finger C3HC-type protein 1; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; mNIPA", "protein_names_refseq": "nuclear interacting partner of anaplastic lymphoma kinase (Alk); nuclear-interacting partner of ALK; zinc finger C3HC-type protein 1 isoform 1; zinc finger C3HC-type protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:232679)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12748172;15345747;17242355;21183079;21750661;22205987;22696294;22955283;32338640", "class_list": "", "function": "Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2)., [RefSeq, PubMed]; Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure., [RefSeq, PubMed]; NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events, [RefSeq, PubMed]; Phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner, [RefSeq, PubMed]; Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results reveal a novel role for NIPA in meiosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJE6;Q80Z11;Q8BTW5;Q8CI56;Q8R3U7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80YV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHP2-1", "uniprot_id": "NUTM1_MOUSE", "mass": 120687.0, "length": 1126, "protein_name": "NUT family member 1", "gene_name": "Nutm1", "organism": "Mouse", "refseq_name": "NUT family member 1", "refseq_ac": "NP_766109", "gene_names_uniprotkb": "Nutm1; Nut", "gene_names_refseq": "4932438M10; Nutm1; Nut", "protein_names_uniprotkb": "NUT family member 1; Nuclear protein in testis", "protein_names_refseq": "NUT family member 1; nuclear protein in testis (Nut); protein NUT", "tax_id": 10090, "disease": "", "pathway": " (mmu:213765)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;30257209;37747726;37819236;38724194", "class_list": "", "function": "Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes., [RefSeq, PubMed]; Inactivation of Nut induces male sterility with spermatogenesis arrest at the histone-removal stage. Nut uses p300 and/or CBP to enhance H4 acetylation., [RefSeq, PubMed]; Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites., [UniProtKB, UniProtKB]; The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BHP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJ71-1", "uniprot_id": "NUP93_MOUSE", "mass": 93281.0, "length": 819, "protein_name": "Nuclear pore complex protein Nup93", "gene_name": "Nup93", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup93 isoform 1", "refseq_ac": "NP_765998", "gene_names_uniprotkb": "Nup93; Cip4; Kiaa0095", "gene_names_refseq": "2410008G02Rik; Nup93", "protein_names_uniprotkb": "Nuclear pore complex protein Nup93; 93 kDa nucleoporin; CBP-interacting protein 4; Nucleoporin Nup93", "protein_names_refseq": "93 kDa nucleoporin; CBP-interacting protein 4; nuclear pore complex protein Nup93 isoform 1; nuclear pore complex protein Nup93; nucleoporin Nup93", "tax_id": 10090, "disease": "nephrotic syndrome type 12 (Disease Ontology:DOID:0080387)", "pathway": " (mmu:71805); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-9615933)", "pathway_count": 19, "publication_count": 10, "publication_id_list": "21750661;26495903;26878725;28528544;31733835;34428180;34887587;37828378;38348753;39627609", "class_list": "", "function": "Nucleoporin93 limits Yap activity to prevent endothelial cell senescence., [RefSeq, PubMed]; Nup93 regulates antiviral innate immunity by enhancing TBK1 activity and IRF3 nuclear translocation., [RefSeq, PubMed]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity). During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (By similarity) (PubMed:26878725)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TED9;Q8BIK7;Q8K1R4;Q8R592", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005813 centrosome;GO:0031965 nuclear membrane;GO:0034399 nuclear periphery", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006998 nuclear envelope organization;GO:0051292 nuclear pore complex assembly;GO:0060391 positive regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BJ71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMC4-1", "uniprot_id": "NOP9_MOUSE", "mass": 70046.0, "length": 636, "protein_name": "Nucleolar protein 9", "gene_name": "Nop9", "organism": "Mouse", "refseq_name": "nucleolar protein 9", "refseq_ac": "NP_080679", "gene_names_uniprotkb": "Nop9", "gene_names_refseq": "2610027L16Rik; Nop9", "protein_names_uniprotkb": "Nucleolar protein 9; Pumilio domain-containing protein NOP9", "protein_names_refseq": "nucleolar protein 9; pumilio domain-containing protein C14orf21 homolog; pumilio domain-containing protein NOP9", "tax_id": 10090, "disease": "", "pathway": " (mmu:67842)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW87;Q8BKR9;Q8BYV4;Q8VEF9;Q9D0C6;Q9D5A8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BMC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BML2-1", "uniprot_id": "OACYL_MOUSE", "mass": 76543.0, "length": 685, "protein_name": "O-acyltransferase like protein", "gene_name": "Oacyl", "organism": "Mouse", "refseq_name": "O-acyltransferase like protein precursor", "refseq_ac": "NP_796002", "gene_names_uniprotkb": "Oacyl", "gene_names_refseq": "5330437I02Rik; Acyl3; Oacyl", "protein_names_uniprotkb": "O-acyltransferase like protein; Protein oacyl", "protein_names_refseq": "O-acyltransferase like protein precursor; O-acyltransferase like protein; acyltransferase 3; protein oacyl", "tax_id": 10090, "disease": "", "pathway": " (mmu:319888)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ12;E9Q6M1;Q8BMK8", "ec_number_list": "", "go_molecular_function": "GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BML2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ09-1", "uniprot_id": "ODC_MOUSE", "mass": 33229.0, "length": 298, "protein_name": "Mitochondrial 2-oxodicarboxylate carrier", "gene_name": "Slc25a21", "organism": "Mouse", "refseq_name": "mitochondrial 2-oxodicarboxylate carrier isoform 1", "refseq_ac": "NP_766165", "gene_names_uniprotkb": "Slc25a21; Odc", "gene_names_refseq": "9930033G19Rik; A630030I10; Slc25a21", "protein_names_uniprotkb": "Mitochondrial 2-oxodicarboxylate carrier; Solute carrier family 25 member 21", "protein_names_refseq": "mitochondrial 2-oxodicarboxylate carrier isoform 1; mitochondrial 2-oxodicarboxylate carrier; mitochondrial solute carrier family 25 member 21", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 18 (Disease Ontology:DOID:0070449)", "pathway": " (mmu:217593); (R-MMU-71064)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;19825180;24642684", "class_list": "", "function": "Disruption of Slc25a21 is associated with orofacial defects and otitis media due to diminished expression of a neighboring gene, pax9. Publication Status: Online-Only, [RefSeq, PubMed]; ODC-AS may promote lipid accumulation during adipocyte differentiation and play an important role in the regulation of lipid metabolism in adipose tissues. [ODS-AS] Publication Status: Online-Only, [RefSeq, PubMed]; Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY72", "ec_number_list": "", "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006869 lipid transport;GO:1990550 mitochondrial alpha-ketoglutarate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BZ09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ39-1", "uniprot_id": "NMUR2_MOUSE", "mass": 44827.0, "length": 395, "protein_name": "Neuromedin-U receptor 2", "gene_name": "Nmur2", "organism": "Mouse", "refseq_name": "neuromedin-U receptor 2", "refseq_ac": "NP_694719", "gene_names_uniprotkb": "Nmur2", "gene_names_refseq": "Nmu2r; Nmur2", "protein_names_uniprotkb": "Neuromedin-U receptor 2; NMU-R2; mNmU-R2", "protein_names_refseq": "NMU-R2; neuromedin-U receptor 2", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:216749); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12217421;15733101;16781063;23349076;30084848;31069918;32057362;36336170", "class_list": "", "function": "Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents., [RefSeq, PubMed]; G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:12217421). Functionally, is involved in regulation of feeding and energy balance (By similarity). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum. GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Molecular basis of the NMU2R regulation of food intake and body weight in mice, [RefSeq, PubMed]; Neuromedin U (NMU) regulates osteoblast differentiation and activity., [RefSeq, PubMed]; Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis., [RefSeq, PubMed]; The circadian rhythm of neuromedin U expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor in the paraventricular nucleus., [RefSeq, PubMed]; The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z76", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0008188 neuropeptide receptor activity;GO:0001607 neuromedin U receptor activity;GO:0042924 neuromedin U binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0050482 arachidonate secretion;GO:0051930 regulation of sensory perception of pain;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007625 grooming behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BZ39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIC2-1", "uniprot_id": "NUP42_MOUSE", "mass": 44337.0, "length": 420, "protein_name": "Nucleoporin NUP42", "gene_name": "Nup42", "organism": "Mouse", "refseq_name": "nucleoporin NUP42 isoform 2", "refseq_ac": "NP_001333511", "gene_names_uniprotkb": "Nup42; Nupl2", "gene_names_refseq": "CG1; NLP-1; Nlp1; Nup42; Nupl2", "protein_names_uniprotkb": "Nucleoporin NUP42; NLP-1; Nucleoporin-like protein 2", "protein_names_refseq": "nucleoporin NUP42 isoform 2; nucleoporin NUP42; nucleoporin like 2; nucleoporin-like protein 1; nucleoporin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231042); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 5, "publication_id_list": "21750661;31219806;31599954;34428180;40997131", "class_list": "", "function": "Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJX3;Q8BVP7;Q924S0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CIC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJ00-1", "uniprot_id": "NOXA1_MOUSE", "mass": 48880.0, "length": 444, "protein_name": "NADPH oxidase activator 1", "gene_name": "Noxa1", "organism": "Mouse", "refseq_name": "NADPH oxidase activator 1 isoform 2", "refseq_ac": "NP_001157098", "gene_names_uniprotkb": "Noxa1", "gene_names_refseq": "NY-CO-31; Noxa1; SDCCAG31", "protein_names_uniprotkb": "NADPH oxidase activator 1", "protein_names_refseq": "NADPH oxidase activator 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:241275); (R-MMU-5668599); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "12473664;12657628;15326186;15949904;16814099;20230789;30576919;31996779;34714114;36201326;36759130", "class_list": "", "function": "Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3., [UniProtKB, PubMed, PubMed, PubMed]; NOXA1-dependent NADPH oxidase 1 signaling mediates angiotensin II activation of the epithelial sodium channel., [RefSeq, PubMed]; Our data support an important role for NOXA1-dependent NADPH oxidase activity in VSMC plasticity during restenosis and atherosclerosis, augmenting VSMC proliferation and migration and KLF4-mediated transition to macrophage-like cells, plaque inflammation, and expansion. Erratum:[Redox Biol. 2026 Mar;90:104033. doi: 10.1016/j.redox.2026.104033. PMID: 41565511], [RefSeq, PubMed]; Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells., [RefSeq, PubMed]; Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling., [RefSeq, PubMed]; Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension., [RefSeq, PubMed]; Role in activating superoxide generation by the NADPH oxidase NOX1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJA1;Q80SY2;Q8BU68", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006801 superoxide metabolic process;GO:0042554 superoxide anion generation;GO:0010310 regulation of hydrogen peroxide metabolic process;GO:0060263 regulation of respiratory burst", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CJ00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1H9-1", "uniprot_id": "OBP2A_MOUSE", "mass": 19996.0, "length": 176, "protein_name": "Odorant-binding protein 2a", "gene_name": "Obp2a", "organism": "Mouse", "refseq_name": "odorant-binding protein 2a precursor", "refseq_ac": "NP_705786", "gene_names_uniprotkb": "Obp2a; Lcn13", "gene_names_refseq": "Lcn13; Obp2a", "protein_names_uniprotkb": "Odorant-binding protein 2a; Epididymal-specific lipocalin-13", "protein_names_refseq": "epididymal-specific lipocalin-13; lipocalin 13; odorant-binding protein 2a precursor; odorant-binding protein 2a", "tax_id": 10090, "disease": "", "pathway": " (mmu:227627)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15363845;21135134;21908604;27827363;33536239;38493698", "class_list": "", "function": "Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation., [RefSeq, PubMed]; Involved in the regulation of systematic glucose homeostasis and insulin sensitivity (PubMed:27827363). Involved in the regulation of liver lipid levels by positive regulation of hepatic lipogenesis and negative regulation of fatty acid beta-oxidation; via downstream transcriptional regulation of CPT1A and hepatic lipogenic program gene expression (PubMed:21908604). May regulate hepatic lipogenesis and fatty acid beta-oxidation in an autocrine or paracrine manner (PubMed:21908604)., [UniProtKB, PubMed, PubMed]; LCN13 decreases liver lipid levels by both inhibiting hepatic lipogenesis and stimulating beta-oxidation, [RefSeq, PubMed]; LCN13 regulates glucose metabolism by both insulin-dependent and insulin-independent mechanisms., [RefSeq, PubMed]; Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0010906 regulation of glucose metabolic process;GO:0042593 glucose homeostasis;GO:0008286 insulin receptor signaling pathway;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K1H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2T1-1", "uniprot_id": "NMRL1_MOUSE", "mass": 34376.0, "length": 309, "protein_name": "NmrA-like family domain-containing protein 1", "gene_name": "Nmral1", "organism": "Mouse", "refseq_name": "nmrA-like family domain-containing protein 1 isoform 2", "refseq_ac": "NP_001277690", "gene_names_uniprotkb": "Nmral1", "gene_names_refseq": "1110025F24Rik; Nmral1", "protein_names_uniprotkb": "NmrA-like family domain-containing protein 1", "protein_names_refseq": "nmrA-like family domain-containing protein 1 isoform 2; nmrA-like family domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67824); (R-MMU-70635)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;21913724;34428180", "class_list": "", "function": "Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVF0;Q9CZP2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K2T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R007-1", "uniprot_id": "NECT4_MOUSE", "mass": 55657.0, "length": 508, "protein_name": "Nectin-4", "gene_name": "Nectin4", "organism": "Mouse", "refseq_name": "nectin-4 isoform b precursor", "refseq_ac": "NP_001116152", "gene_names_uniprotkb": "Nectin4; Lnir; Prr4; Pvrl4", "gene_names_refseq": "1200017F15Rik; Nectin4; Prr4; Pvrl4", "protein_names_uniprotkb": "Nectin-4; Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4", "protein_names_refseq": "ig superfamily receptor LNIR; nectin 4; nectin-4 isoform b precursor; poliovirus receptor-related 4; poliovirus receptor-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71740); (R-MMU-418990); (R-MMU-420597)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11544254;20691405;21901103;32554531;36457999", "class_list": "", "function": "Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1. Publication Status: Online-Only, [RefSeq, PubMed]; Ectodermal dysplasia-syndactyly syndrome is the second known 'nectinopathy' caused by mutations in a nectin adhesion molecule., [RefSeq, PubMed]; Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue., [RefSeq, PubMed]; Nectin4 is a potential therapeutic target for asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence-associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Also participates in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK-cell activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U318;Q8CED8;Q9DBP8", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0048018 receptor ligand activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0046718 symbiont entry into host cell;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R007-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1N4-1", "uniprot_id": "NUDC3_MOUSE", "mass": 40890.0, "length": 363, "protein_name": "NudC domain-containing protein 3", "gene_name": "Nudcd3", "organism": "Mouse", "refseq_name": "nudC domain-containing protein 3 isoform 1", "refseq_ac": "NP_776109", "gene_names_uniprotkb": "Nudcd3; Kiaa1068", "gene_names_refseq": "Nudcd3; mKIAA1068", "protein_names_uniprotkb": "NudC domain-containing protein 3", "protein_names_refseq": "nudC domain-containing protein 3 isoform 1; nudC domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:209586)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX16;Q5SVV6;Q5SVV7;Q6PFE4;Q6ZPZ2;Q8BL70;Q8BWN3;Q8BWW5", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:1905793 protein localization to pericentriolar material;GO:0060271 cilium assembly;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R1N4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R332-1", "uniprot_id": "NUP58_MOUSE", "mass": 59445.0, "length": 587, "protein_name": "Nucleoporin p58/p45", "gene_name": "Nup58", "organism": "Mouse", "refseq_name": "nucleoporin p58/p45 isoform 1", "refseq_ac": "NP_733479", "gene_names_uniprotkb": "Nup58; Nupl1", "gene_names_refseq": "1700017F11Rik; Nup58; Nupl1; mKIAA0410", "protein_names_uniprotkb": "Nucleoporin p58/p45; 58 kDa nucleoporin; Nucleoporin-like protein 1", "protein_names_refseq": "58 kDa nucleoporin; nucleoporin like 1; nucleoporin p58/p45 isoform 1; nucleoporin p58/p45; nucleoporin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71844); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 11, "publication_id_list": "26495903;29125738;29187734;31219806;33300544;34428180;34887587;35820727;36852467;40021952;40997131", "class_list": "", "function": "Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJF4;Q8BUA7;Q8BVG7;Q8C0W3", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0042306 regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8R332-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCM2-1", "uniprot_id": "NOXO1_MOUSE", "mass": 38827.0, "length": 349, "protein_name": "NADPH oxidase organizer 1", "gene_name": "Noxo1", "organism": "Mouse", "refseq_name": "NADPH oxidase organizer 1", "refseq_ac": "NP_082264", "gene_names_uniprotkb": "Noxo1; Snx28", "gene_names_refseq": "2310034C04Rik; Noxo1; P41NOXA; P41NOXB; P41NOXC; P41NOX; Snx28; hslt", "protein_names_uniprotkb": "NADPH oxidase organizer 1; Nox organizer 1; Sorting nexin-28", "protein_names_refseq": "NADPH oxidase organizer 1; nox organizer 1; sorting nexin-28", "tax_id": 10090, "disease": "", "pathway": " (mmu:71893); (R-MMU-5668599); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12473664;15949904;16431374;17140397;20454568;27283741;29195137;32949971", "class_list": "", "function": "Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity., [UniProtKB, PubMed, PubMed]; Deletion of NoxO1 limits atherosclerosis development in female mice., [RefSeq, PubMed]; NoxO1 stimulates alpha-secretase activity probably through reactive oxygen species-mediated oxidation. Deletion of NoxO1 attenuates Notch signaling and thereby promotes a tip-cell phenotype that results in increased angiogenesis., [RefSeq, PubMed]; ROS production stimulated by NoxO1 and p47phox limit endothelium-dependent relaxation and maintain blood pressure in mice. However, NoxO1 and p47phox cannot substitute each other despite their similar effect on vascular function. Deletion of NoxO1 induced an anti-inflammatory phenotype, whereas p47phox deletion rather elicited a hyper-inflammatory response., [RefSeq, PubMed]; Role in activating superoxide generation by the NADPH oxidase NOX1, [RefSeq, PubMed]; The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZA4;Q8BH41;Q9D747", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0035091 phosphatidylinositol binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0022617 extracellular matrix disassembly;GO:0006801 superoxide metabolic process;GO:0042554 superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VES2-1", "uniprot_id": "O5T17_MOUSE", "mass": 36292.0, "length": 324, "protein_name": "Olfactory receptor 5T17", "gene_name": "Or5t17", "organism": "Mouse", "refseq_name": "olfactory receptor 5T17", "refseq_ac": "NP_997037", "gene_names_uniprotkb": "Or5t17; Mor179-4; Olfr1102", "gene_names_refseq": "MOR179-4; Olfr1102; Or5t17", "protein_names_uniprotkb": "Olfactory receptor 5T17; Olfactory receptor 1102; Olfactory receptor 179-4", "protein_names_refseq": "GA_x6K02T2Q125-48487992-48488966; olfactory receptor 1102; olfactory receptor 179-4; olfactory receptor 5T17", "tax_id": 10090, "disease": "", "pathway": " (mmu:228228)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AVB4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VES2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VF13-1", "uniprot_id": "OR5T9_MOUSE", "mass": 37363.0, "length": 330, "protein_name": "Olfactory receptor 5T9", "gene_name": "Or5t9", "organism": "Mouse", "refseq_name": "olfactory receptor 5T9", "refseq_ac": "NP_666477", "gene_names_uniprotkb": "Or5t9; Mor179-7; Olfr1094", "gene_names_refseq": "MOR179-7; Olfr1094; Or5t9", "protein_names_uniprotkb": "Olfactory receptor 5T9; Olfactory receptor 1094; Olfactory receptor 179-7", "protein_names_refseq": "GA_x6K02T2Q125-48321457-48322449; olfactory receptor 1094; olfactory receptor 179-7; olfactory receptor 5T9; olfactory receptor MOR179-7", "tax_id": 10090, "disease": "", "pathway": " (mmu:258362)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VF13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFL5-1", "uniprot_id": "OR5M5_MOUSE", "mass": 36382.0, "length": 318, "protein_name": "Olfactory receptor 5M5", "gene_name": "Or5m5", "organism": "Mouse", "refseq_name": "olfactory receptor 5M5", "refseq_ac": "NP_666799", "gene_names_uniprotkb": "Or5m5; Mor196-2; Olfr1030", "gene_names_refseq": "MOR196-2; Olfr1030; Or5m5", "protein_names_uniprotkb": "Olfactory receptor 5M5; Olfactory receptor 1030; Olfactory receptor 196-2", "protein_names_refseq": "GA_x6K02T2Q125-47462755-47463693; olfactory receptor 1030; olfactory receptor 196-2; olfactory receptor 5M5; olfactory receptor MOR196-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258581)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFV4-1", "uniprot_id": "O5AN6_MOUSE", "mass": 34943.0, "length": 315, "protein_name": "Olfactory receptor 5AN6", "gene_name": "Or5an6", "organism": "Mouse", "refseq_name": "olfactory receptor 5AN6", "refseq_ac": "NP_666895", "gene_names_uniprotkb": "Or5an6; Mor215-1; Olfr1440", "gene_names_refseq": "MOR215-1; Olfr1440; Or5an6", "protein_names_uniprotkb": "Olfactory receptor 5AN6; Olfactory receptor 1440; Olfactory receptor 202-4", "protein_names_refseq": "GA_x6K02T2RE5P-2725206-2726153; olfactory receptor 1440; olfactory receptor 202-4; olfactory receptor 5AN6; olfactory receptor MOR215-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258679)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24361078;27098692;29438653;30038239", "class_list": "", "function": "Odorant receptor specific for muscone (PubMed:24361078, PubMed:27098692, PubMed:30038239). Muscone-binding causes a conformation change that triggers signaling via G(s)-class of G alpha protein GNAL, activating adenylyl cyclase (Probable)., [UniProtKB, PubMed, PubMed, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Stereochemical study of mouse muscone receptor MOR215-1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VFV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGR8-1", "uniprot_id": "OR5J3_MOUSE", "mass": 34552.0, "length": 312, "protein_name": "Olfactory receptor 5J3", "gene_name": "Or5j3", "organism": "Mouse", "refseq_name": "olfactory receptor 5J3", "refseq_ac": "NP_667221", "gene_names_uniprotkb": "Or5j3; Mor172-1; Olfr1052", "gene_names_refseq": "MOR172-1; Olfr1052; Or5j3", "protein_names_uniprotkb": "Olfactory receptor 5J3; Olfactory receptor 1052; Olfactory receptor 172-1", "protein_names_refseq": "GA_x6K02T2Q125-47777498-47778436; olfactory receptor 1052; olfactory receptor 172-1; olfactory receptor 5J3; olfactory receptor MOR172-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:259012)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0PK46;A2AVX6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGS1-1", "uniprot_id": "OR8U3_MOUSE", "mass": 36135.0, "length": 319, "protein_name": "Olfactory receptor 8U3", "gene_name": "Or8u3", "organism": "Mouse", "refseq_name": "olfactory receptor 8U3", "refseq_ac": "NP_667224", "gene_names_uniprotkb": "Or8u3; Mor185-3; Olfr1038-ps; Olfr1038; Or8u3-ps", "gene_names_refseq": "MOR185-3; Olfr1038-ps; Olfr1038; Or8u3-ps; Or8u3", "protein_names_uniprotkb": "Olfactory receptor 8U3; Olfactory receptor 1038; Olfactory receptor 185-3", "protein_names_refseq": "GA_x6K02T2Q125-47591072-47592031; olfactory receptor 1038, pseudogene; olfactory receptor 185-3; olfactory receptor 8U3; olfactory receptor MOR185-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:259015)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene appears to represent a strain-specific polymorphic pseudogene in mouse, where some strains, including the C57BL/6 reference genome strain, have a non-functional allele, while other strains have a protein-coding allele. [provided by RefSeq, Jan 2019]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VT1-1", "uniprot_id": "NSE2_MOUSE", "mass": 28231.0, "length": 247, "protein_name": "E3 SUMO-protein ligase NSE2", "gene_name": "Nsmce2", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase NSE2 isoform 2", "refseq_ac": "NP_001158076", "gene_names_uniprotkb": "Nsmce2; Mms21", "gene_names_refseq": "1110014D18Rik; Nsmce2", "protein_names_uniprotkb": "E3 SUMO-protein ligase NSE2; 2.3.2.-; E3 SUMO-protein transferase NSE2; MMS21 homolog; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog", "protein_names_refseq": "E3 SUMO-protein ligase NSE2 isoform 2; E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; MMS21 homolog; non-SMC element 2 homolog (MMS21, S. cerevisiae); non-structural maintenance of chromosomes element 2 homolog", "tax_id": 10090, "disease": "Seckel syndrome 10 (Disease Ontology:DOID:0070008); Bloom syndrome (Disease Ontology:DOID:2717)", "pathway": " (mmu:68501); (R-MMU-3108214)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;22872234;26443207;30779550;31219806", "class_list": "", "function": "E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate chromosome segregation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ88;Q9D1D3", "ec_number_list": "2.3.2.-;2.3.2.27", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0016925 protein sumoylation;GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91VT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VX5-1", "uniprot_id": "NXPH3_MOUSE", "mass": 28183.0, "length": 252, "protein_name": "Neurexophilin-3", "gene_name": "Nxph3", "organism": "Mouse", "refseq_name": "neurexophilin-3 precursor", "refseq_ac": "NP_570928", "gene_names_uniprotkb": "Nxph3", "gene_names_refseq": "Nxph3", "protein_names_uniprotkb": "Neurexophilin-3", "protein_names_refseq": "neurexophilin-3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:104079)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16055736;26041738;30899004;9570794", "class_list": "", "function": "May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins., [UniProtKB]; Neurexophilin 3 has a role as a locally and temporally regulated neuropeptide-like molecule, presumably acting in a complex with alpha-neurexins in select neuronal circuits, [RefSeq, PubMed]; We report that a secreted peptide, neurexophilin 3 (NXPH3), supports the survival of mouse induced pluripotent stem cell-derived (iPSC-derived) dopaminergic (DA) neurons in vitro and in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8836, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91VX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920Q8-1", "uniprot_id": "NS1BP_MOUSE", "mass": 71581.0, "length": 642, "protein_name": "Influenza virus NS1A-binding protein homolog", "gene_name": "Ivns1abp", "organism": "Mouse", "refseq_name": "influenza virus NS1A-binding protein homolog isoform 1", "refseq_ac": "NP_001034600", "gene_names_uniprotkb": "Ivns1abp; Kiaa0850; Nd1L; Nd1S; Nd1; Ns1bp; Ns1", "gene_names_refseq": "1190004M08Rik; 1700126I16Rik; HSPC068; Ivns1abp; ND1; NS-1; NS1-BP; Nd1-L; Nd1-S; mKIAA0850", "protein_names_uniprotkb": "Influenza virus NS1A-binding protein homolog; Kelch family protein Nd1-L; ND1-L2; NS1-BP; NS1-binding protein homolog; Nd1-S", "protein_names_refseq": "ND1-L2; NS1-binding protein homolog; influenza virus NS1A-binding protein homolog isoform 1; influenza virus NS1A-binding protein homolog; kelch family protein Nd1-L; kelch family protein Nd1", "tax_id": 10090, "disease": "immunodeficiency 70 (Disease Ontology:DOID:0112005)", "pathway": " (mmu:117198)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11418182;12213805;15485691;15684717;16317045;16952015;17016628;21183079;21750661;30084848;30124330;38473707", "class_list": "", "function": "Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (PubMed:12213805, PubMed:16317045). Protects cells from cell death induced by actin destabilization (PubMed:16952015). Functions as a modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (By similarity). Inhibits pre-mRNA splicing (in vitro) (By similarity). May play a role in mRNA nuclear export (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; May play a role in cell cycle progression in the nucleus., [UniProtKB, PubMed]; Nd1-L functions as a stabilizer of actin filaments as an actin-binding protein and may play a role in the dynamic organization of the actin cytoskeleton, [RefSeq, PubMed]; Overexpression of short variant form of new Kelch family protein ND1 leads to erythroid and megakaryocyte dysplasia by targeting megakaryocyte-erythroid progenitors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06BK6;Q3TXI1;Q3UJE3;Q3UJS1;Q3UKH9;Q3UMK9;Q6ZQ34;Q99KN0;Q9D978", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0009615 response to virus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0008380 RNA splicing;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q920Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JR6-1", "uniprot_id": "NMNA3_MOUSE", "mass": 27703.0, "length": 245, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3", "gene_name": "Nmnat3", "organism": "Mouse", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform a", "refseq_ac": "NP_653116", "gene_names_uniprotkb": "Nmnat3", "gene_names_refseq": "4933408N02Rik; Nmnat3; PNAT3", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3; 2.7.7.18; 2.7.7.1; NMN adenylyltransferase 3; NMN/NaMN adenylyltransferase 3; NaMN adenylyltransferase 3; Nicotinamide-nucleotide adenylyltransferase 3; Nicotinate-nucleotide adenylyltransferase 3", "protein_names_refseq": "NMN adenylyltransferase 3; NMN/NaMN adenylyltransferase 3; naMN adenylyltransferase 1; naMN adenylyltransferase 3; nicotinamide mononucleotide adenylyltransferase 3; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform a; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 3", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:74080); (R-MMU-196807)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16914673;19439605;21750661;22425156", "class_list": "", "function": "Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following injury (PubMed:16914673). May be involved in the maintenance of axonal integrity (PubMed:22425156). Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results suggest that axonal protection by NMNAT expression in neurons is provided by modifying mitochondrial functionNMNAT activity does lead to axonal protection phenotype in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58E37", "ec_number_list": "2.7.7.1;2.7.7.18", "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0034612 response to tumor necrosis factor;GO:0009611 response to wounding;GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99JR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3H2-1", "uniprot_id": "OBP1A_MOUSE", "mass": 18469.0, "length": 163, "protein_name": "Odorant-binding protein 1a", "gene_name": "Obp1a", "organism": "Mouse", "refseq_name": "odorant-binding protein 1a precursor", "refseq_ac": "NP_032780", "gene_names_uniprotkb": "Obp1a", "gene_names_refseq": "OBP-1a; OBP5; Obp1a", "protein_names_uniprotkb": "Odorant-binding protein 1a; Odorant-binding protein IA", "protein_names_refseq": "odorant binding protein 5; odorant-binding protein 1a precursor; odorant-binding protein 1a; odorant-binding protein Ia", "tax_id": 10090, "disease": "", "pathway": " (mmu:18249)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;20237294;8529023;9661663", "class_list": "", "function": "A novel lacrimal gland autoantigen OBP1a is expressed in the thymus in an Aire-dependent fashion, suggesting that defective thymic expression of OBP1a may play a role in the spontaneous dacryoadenitis that develops in the Aire-deficient mouse model., [RefSeq, PubMed]; Binds the chemical odorant 2-isobutyl-3-methoxypyrazine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97336", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D3H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D611-1", "uniprot_id": "OCSTP_MOUSE", "mass": 54574.0, "length": 498, "protein_name": "Osteoclast stimulatory transmembrane protein", "gene_name": "Ocstamp", "organism": "Mouse", "refseq_name": "osteoclast stimulatory transmembrane protein", "refseq_ac": "NP_083297", "gene_names_uniprotkb": "Ocstamp", "gene_names_refseq": "4833422F24Rik; OC-STAMP; Ocstamp", "protein_names_uniprotkb": "Osteoclast stimulatory transmembrane protein; OC-STAMP", "protein_names_refseq": "osteoclast stimulatory transmembrane protein; transmembrane protein C20orf123 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74614)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18064667;20882308;22337159;23444125;28981605;29533736;38073205", "class_list": "", "function": "Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP., [RefSeq, PubMed]; OC-STAMP is a previously unknown, RANKL-induced, multipass transmembrane protein that promotes the formation of multinucleated osteoclasts. (Osteoclast stimulatory transmembrane protein), [RefSeq, PubMed]; OC-STAMP is a regulatory molecule for FBGCs; and that they are functionally distinct from OCs, despite similarities in gene expression profile, podosome belt formation, and TRAP expression., [RefSeq, PubMed]; Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation., [UniProtKB, PubMed, PubMed, PubMed]; Results indicte that oc-stamp may play an important role in macrophage polarization and inhibit the M1 pro-inflammatory state., [RefSeq, PubMed]; Significantly lower level of bone resorption was found in OC-STAMP-KO mice compared to WT mice. OC-STAMP partners CD9 to promote periodontal bone destruction., [RefSeq, PubMed]; The osteoclast differentiation needs the coordinated expression of OC-STAMP with several molecules required for transcription, signaling transduction, and cell fusion., [RefSeq, PubMed]; [The mechanism of OC-STAMP overexpression induced actin cytoskeleton remodeling in promoting epithelial-mesenchymal transition in the alveolar type epithelial cell]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C046", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0034241 positive regulation of macrophage fusion;GO:0071356 cellular response to tumor necrosis factor;GO:0071391 cellular response to estrogen stimulus;GO:0045672 positive regulation of osteoclast differentiation;GO:0072674 multinuclear osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7C9-1", "uniprot_id": "NRK2_MOUSE", "mass": 22375.0, "length": 195, "protein_name": "Nicotinamide riboside kinase 2", "gene_name": "Nmrk2", "organism": "Mouse", "refseq_name": "nicotinamide riboside kinase 2", "refseq_ac": "NP_081396", "gene_names_uniprotkb": "Nmrk2; Itgb1bp3; Nrk2", "gene_names_refseq": "2310015C21Rik; Itgb1bp3; Mibp; Nmrk2", "protein_names_uniprotkb": "Nicotinamide riboside kinase 2; 2.7.1.173; 2.7.1.22; Integrin beta-1-binding protein 3; MIBP; Muscle integrin-binding protein; NRK 2; Nicotinic acid riboside kinase 2; NmR-K 2; RNK 2; Ribosylnicotinamide kinase 2; Ribosylnicotinic acid kinase 2", "protein_names_refseq": "NRK 2; RNK 2; integrin beta 1 binding protein 3; muscle integrin-binding protein; muscle-specific beta 1 integrin binding protein; nicotinamide riboside kinase 2; nicotinic acid riboside kinase 2; nmR-K 2; ribosylnicotinamide kinase 2; ribosylnicotinic acid kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69564); (R-MMU-196807)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10613898;12941630;36808555", "class_list": "", "function": "Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis (By similarity)., [UniProtKB, PubMed]; Functions in the control of myogenic differentiation by regulating alpha7beta1 integrin-mediated cell interactions with laminin matrix and intracellular signaling through paxillin., [RefSeq, PubMed]; Nicotinamide riboside kinase-2 regulates metabolic adaptation in the ischemic heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEG2;Q3UV96", "ec_number_list": "2.7.1.173;2.7.1.22", "go_molecular_function": "GO:0050262 ribosylnicotinamide kinase activity;GO:0061769 nicotinate riboside kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0045662 negative regulation of myoblast differentiation;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERH4-1", "uniprot_id": "NUSAP_MOUSE", "mass": 48573.0, "length": 427, "protein_name": "Nucleolar and spindle-associated protein 1", "gene_name": "Nusap1", "organism": "Mouse", "refseq_name": "nucleolar and spindle-associated protein 1 isoform b", "refseq_ac": "NP_001036117", "gene_names_uniprotkb": "Nusap1", "gene_names_refseq": "2610201A12Rik; ANKT; BM037; LNP; NuSAP; Nusap1; Q0310; SAPL", "protein_names_uniprotkb": "Nucleolar and spindle-associated protein 1; NuSAP", "protein_names_refseq": "nucleolar and spindle-associated protein 1 isoform b; nucleolar protein ANKT", "tax_id": 10090, "disease": "", "pathway": " (mmu:108907)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12963707;17054671;17276916;30084848;34428180;37992207", "class_list": "", "function": "Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them., [UniProtKB, PubMed, PubMed]; NUSAP1 regulates mouse oocyte meiotic maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2L8;Q8C989;Q921Z0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005694 chromosome;GO:0072686 mitotic spindle", "go_biological_process": "GO:0007076 mitotic chromosome condensation;GO:0000281 mitotic cytokinesis;GO:0040001 establishment of mitotic spindle localization;GO:0045840 positive regulation of mitotic nuclear division;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ERH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLB9-1", "uniprot_id": "NECT3_MOUSE", "mass": 60583.0, "length": 549, "protein_name": "Nectin-3", "gene_name": "Nectin3", "organism": "Mouse", "refseq_name": "nectin-3 isoform alpha", "refseq_ac": "NP_067470", "gene_names_uniprotkb": "Nectin3; Pvrl3", "gene_names_refseq": "2610301B19Rik; 3000002N23Rik; 4921513D19Rik; CD113; Nectin3; Pvrl3", "protein_names_uniprotkb": "Nectin-3; Nectin cell adhesion molecule 3; Poliovirus receptor-related protein 3", "protein_names_refseq": "nectin-3 isoform alpha; nectin-3; poliovirus receptor-related 3; poliovirus receptor-related protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:58998); (R-MMU-418990); (R-MMU-420597)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10744716;11827984;12121624;12558799;12826663;15328010;15728677;15741237;16128743;16300961;17242355;21750661;21798896;25428506;31219806;32385776;33160402;34428180;37828378", "class_list": "", "function": "Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:10744716, PubMed:11827984, PubMed:12121624, PubMed:12558799, PubMed:15328010, PubMed:16128743, PubMed:21798896). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16128743). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16128743). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (PubMed:15328010). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (PubMed:11827984). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (PubMed:21798896). Plays a role in the morphology of the ciliary body (PubMed:15728677)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis, [RefSeq, PubMed]; Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex. Publication Status: Online-Only, [RefSeq, PubMed]; Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q059N7;Q9D006;Q9JLB7;Q9JLB8", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007155 cell adhesion;GO:0009566 fertilization;GO:0098609 cell-cell adhesion;GO:0046718 symbiont entry into host cell", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9JLB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXX8-1", "uniprot_id": "NUFP1_MOUSE", "mass": 54713.0, "length": 484, "protein_name": "FMR1-interacting protein NUFIP1", "gene_name": "Nufip1", "organism": "Mouse", "refseq_name": "FMR1-interacting protein NUFIP1 isoform 1", "refseq_ac": "NP_038773", "gene_names_uniprotkb": "Nufip1", "gene_names_refseq": "Nufip1; Nufip", "protein_names_uniprotkb": "FMR1-interacting protein NUFIP1; Nuclear FMRP-interacting protein 1", "protein_names_refseq": "FMR1-interacting protein NUFIP1 isoform 1; FMR1-interacting protein NUFIP1; nuclear FMRP-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27275)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10556305;25428506;31219806", "class_list": "", "function": "Binds RNA., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV69", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000492 box C/D snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QXX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZV9-1", "uniprot_id": "NXT1_MOUSE", "mass": 15847.0, "length": 140, "protein_name": "NTF2-related export protein 1", "gene_name": "Nxt1", "organism": "Mouse", "refseq_name": "NTF2-related export protein 1", "refseq_ac": "NP_001103629", "gene_names_uniprotkb": "Nxt1", "gene_names_refseq": "1110001N02Rik; Nxt1", "protein_names_uniprotkb": "NTF2-related export protein 1", "protein_names_refseq": "NTF2-related export protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56488); (R-MMU-159236)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10567585;18048358;25428506;25605945;30084848;30779550;34428180;35219094", "class_list": "", "function": "Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents., [RefSeq, PubMed]; Regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport by ERK map kinases requires TAP-NxT1 binding and the AU-rich element, [RefSeq, PubMed]; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THE3;Q9D1P7", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0042272 nuclear RNA export factor complex;GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006611 protein export from nucleus;GO:0006405 RNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QZV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR47-1", "uniprot_id": "NSA2_MOUSE", "mass": 30036.0, "length": 260, "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "Nsa2", "organism": "Mouse", "refseq_name": "ribosome biogenesis protein NSA2 homolog", "refseq_ac": "NP_067527", "gene_names_uniprotkb": "Nsa2; Tinp1", "gene_names_refseq": "5730427N09Rik; LNR42; Nsa2p; Nsa2; Tinp1; Yr29", "protein_names_uniprotkb": "Ribosome biogenesis protein NSA2 homolog; L-name-related protein 42; LNR42; TGF-beta-inducible nuclear protein 1", "protein_names_refseq": "L-name related protein; L-name-related protein 42; TGF-beta-inducible nuclear protein 1; ribosome biogenesis protein NSA2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:59050)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20173027;21750661;22095236;30084848;30779550;34428180", "class_list": "", "function": "Data suggest that renal and circulating NSA2 levels are increased in hyperglycemia in experimental models of diabetes, and that circulating NSA2 is elevated in diabetic nephropathy patients with albuminuria., [RefSeq, PubMed]; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JNU8;Q8BHQ6;Q8BHT0;Q9CRQ0;Q9CS34;Q9CYK0;Q9JKF9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0030684 preribosome", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA;GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CR47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0G8-1", "uniprot_id": "NRK_MOUSE", "mass": 163647.0, "length": 1455, "protein_name": "Nik-related protein kinase", "gene_name": "Nrk", "organism": "Mouse", "refseq_name": "nik-related protein kinase", "refseq_ac": "NP_038752", "gene_names_uniprotkb": "Nrk; Nesk", "gene_names_refseq": "Nesk; Nrk", "protein_names_uniprotkb": "Nik-related protein kinase; 2.7.11.1; NESK; NIK-like embryo-specific kinase; Nck-interacting kinase-like embryo specific kinase", "protein_names_refseq": "NIK-like embryo-specific kinase; nck-interacting kinase-like embryo specific kinase; nik-related protein kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:27206)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10559491;10801798;12837278;21183079;21715335;21750661;27634343;28152035;30016717;31783915", "class_list": "", "function": "May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-induced signaling pathway., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor., [RefSeq, PubMed]; Protein expression profiles were analyzed in the Nrk-null placenta. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates trophoblast proliferation and placental development by modulating AKT phosphorylation Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that Nrk suppresses the excessive proliferation of mammary epithelial cells during pregnancy, and the impairment of this regulatory system leads to frequent occurrence of breast tumor in Nrk mutant mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RSW5;Q6NV55;Q8C9S9;Q9R0S4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0046330 positive regulation of JNK cascade;GO:0007567 parturition;GO:0060721 regulation of spongiotrophoblast cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9R0G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70571-1", "uniprot_id": "PDK4_MOUSE", "mass": 46596.0, "length": 412, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial", "gene_name": "Pdk4", "organism": "Mouse", "refseq_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial", "refseq_ac": "NP_038771", "gene_names_uniprotkb": "Pdk4", "gene_names_refseq": "Pdk4", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; 2.7.11.2; Pyruvate dehydrogenase kinase isoform 4", "protein_names_refseq": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:27273); (R-MMU-204174); (R-MMU-5362517)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11554740;12099888;16606348;17669420;18083902;18430968;19627255;21321124;21750661;21803180;22360721;22436846;34428180;38096914;38311057", "class_list": "", "function": "Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid Metabolism in Hyperlipidemic Mice., [RefSeq, PubMed]; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice., [RefSeq, PubMed]; The activation of pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha, [RefSeq, PubMed]; Upregulation of PDK4 in skeletal muscle, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.3.1.-;1.8.1.4;1.14.11.68;2.7.11.2;2.7.11.-;1.2.4.1;2.1.1.364;2.3.1.12;2.7.11.22;2.7.11.23", "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0010565 regulation of ketone metabolic process;GO:0006468 protein phosphorylation;GO:0042594 response to starvation;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O70571-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UD82-1", "uniprot_id": "PARP8_MOUSE", "mass": 95560.0, "length": 852, "protein_name": "Protein mono-ADP-ribosyltransferase PARP8", "gene_name": "Parp8", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP8 isoform 2", "refseq_ac": "NP_001413994", "gene_names_uniprotkb": "Parp8; D13Ertd275e", "gene_names_refseq": "2810430O08Rik; ARTD16; D13Ertd275e; Parp8", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP8; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 16; ARTD16; PARP-8; Poly [ADP-ribose] polymerase 8", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 16; PARP-8; poly [ADP-ribose] polymerase 8; protein mono-ADP-ribosyltransferase PARP8 isoform 2; protein mono-ADP-ribosyltransferase PARP8", "tax_id": 10090, "disease": "", "pathway": " (mmu:52552)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20173027;21750661;31219806", "class_list": "", "function": "Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDE4;Q3UDU5;Q8VCB5;Q9CYY3", "ec_number_list": "2.4.2.-;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UD82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2TJV2-1", "uniprot_id": "PALM3_MOUSE", "mass": 78788.0, "length": 734, "protein_name": "Paralemmin-3", "gene_name": "Palm3", "organism": "Mouse", "refseq_name": "paralemmin-3", "refseq_ac": "NP_083153", "gene_names_uniprotkb": "Palm3", "gene_names_refseq": "4432412L15Rik; Palm3", "protein_names_uniprotkb": "Paralemmin-3", "protein_names_refseq": "paralemmin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74337)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11478809;21183079;26772416", "class_list": "", "function": "ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling., [UniProtKB]; PALM3 contributes to the development of acute lung injury in mice challenged with lipopolysaccharide., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRS0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0008360 regulation of cell shape;GO:0008063 Toll signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2TJV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05793-1", "uniprot_id": "PGBM_MOUSE", "mass": 398294.0, "length": 3707, "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein", "gene_name": "Hspg2", "organism": "Mouse", "refseq_name": "basement membrane-specific heparan sulfate proteoglycan core protein precursor", "refseq_ac": "NP_032331", "gene_names_uniprotkb": "Hspg2", "gene_names_refseq": "HSPG; Hspg2; Pcn; Plc; per", "protein_names_uniprotkb": "Basement membrane-specific heparan sulfate proteoglycan core protein; HSPG; Perlecan", "protein_names_refseq": "basement membrane-specific heparan sulfate proteoglycan core protein precursor; basement membrane-specific heparan sulfate proteoglycan core protein", "tax_id": 10090, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); Schwartz-Jampel syndrome 1 (Disease Ontology:DOID:0090005); Silverman-Handmaker type dyssegmental dysplasia (Disease Ontology:DOID:0090032); hypertension (Disease Ontology:DOID:10763); thanatophoric dysplasia (Disease Ontology:DOID:13481); osteochondrodysplasia (Disease Ontology:DOID:2256); carotid artery disease (Disease Ontology:DOID:3407); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (mmu:15530)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;10022829;10545953;11157973;11427896;11802174;15591058;16098969;16407285;1744087;18694874;19349973;19656770;21750661;22517741;22645316;26495903;2972708;30899004;31219806;31599954;33300544;34418053;34428180;36288343;36792666;37507081;37828378;39927985;40885482;7649154;9431988", "class_list": "glycogene", "function": "Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Has anti-angiogenic properties that require binding of calcium ions for full activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Integral component of basement membranes that serve as an attachment substrate for cells, and is involved in multiple processes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity). In muscle, it is essential for localizing acetylcholinesterase (AChE) at the neuromuscular junctions (NMJ), most probably acting as an adapter that links the acetylcholinesterase collagenic tail peptide (COLQ) to alpha-dystroglycan, and is therefore involved in the down-regulation of colinergic synaptic transmission (PubMed:11157973, PubMed:11802174)., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 2, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 132, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 8, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0005509 calcium ion binding;GO:0002162 dystroglycan binding;GO:0070052 collagen V binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0001527 microfibril", "go_biological_process": "GO:0001525 angiogenesis;GO:0007162 negative regulation of cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0030198 extracellular matrix organization;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 6.0, "record_id": "Q05793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B3GLJ3-1", "uniprot_id": "PATE3_MOUSE", "mass": 11660.0, "length": 98, "protein_name": "Prostate and testis expressed protein 3", "gene_name": "Pate3", "organism": "Mouse", "refseq_name": "prostate and testis expressed protein 3 precursor", "refseq_ac": "NP_001161064", "gene_names_uniprotkb": "Pate3; Gm17365", "gene_names_refseq": "Gm17365; Pate-dj; Pate3", "protein_names_uniprotkb": "Prostate and testis expressed protein 3; Epididymis-specific ESC112; PATE-DJ; PATE-like protein DJ", "protein_names_refseq": "PATE-like protein DJ; epididymis-specific ESC112; prostate and testis expressed DJ; prostate and testis expressed protein 3 precursor; prostate and testis expressed protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:100312956)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18387948", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D8KWR6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B3GLJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C871-1", "uniprot_id": "PA24B_MOUSE", "mass": 88448.0, "length": 782, "protein_name": "Cytosolic phospholipase A2 beta", "gene_name": "Pla2g4b", "organism": "Mouse", "refseq_name": "cytosolic phospholipase A2 beta", "refseq_ac": "NP_663353", "gene_names_uniprotkb": "Pla2g4b", "gene_names_refseq": "A030011C02Rik; Gm1013; Pla2g4b; cPLA2-beta", "protein_names_uniprotkb": "Cytosolic phospholipase A2 beta; 3.1.1.4; 3.1.1.5; Lysophospholipase A1 group IVB; Phospholipase A2 group IVB; cPLA2-beta", "protein_names_refseq": "cytosolic phospholipase A2 beta; lysophospholipase A1 group IVB; phospholipase A2 group IVB", "tax_id": 10090, "disease": "", "pathway": " (mmu:211429); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482925); (R-MMU-1483115); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "15866882;20167866;20705608;21750661;33641447", "class_list": "", "function": "Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. The PLA1 versus PLA2 activity ratio appears to depend on the phospholipid headgroup, with mainly PLA2 activity toward anionic phospholipids such as phosphatidylglycerols. Hydrolyzes with high efficiency lysophospholipids enabling complete deacylation., [UniProtKB, PubMed]; Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation., [RefSeq, PubMed]; Murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta, [RefSeq, PubMed]; TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AP62;Q4QQM1;Q80VV8;Q91W88", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.43;3.1.1.32;3.1.1.3;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;3.4.11.-;2.3.1.51;3.1.4.-;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56812-1", "uniprot_id": "PDCD5_MOUSE", "mass": 14275.0, "length": 126, "protein_name": "Programmed cell death protein 5", "gene_name": "Pdcd5", "organism": "Mouse", "refseq_name": "programmed cell death protein 5", "refseq_ac": "NP_062720", "gene_names_uniprotkb": "Pdcd5; Tfar19", "gene_names_refseq": "2200003D22Rik; Pdcd5; Tfar19", "protein_names_uniprotkb": "Programmed cell death protein 5; Protein TFAR19; TF-1 cell apoptosis-related protein 19", "protein_names_refseq": "TF-1 cell apoptosis-related protein 19; programmed cell death protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:56330)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "15345747;17242355;17393091;19131326;21183079;21750661;21952136;22177044;22282256;25428506;28051100;29588416;29921968;30084848;34011956;34428180;34480939;35820727;9920759", "class_list": "", "function": "Club cell-specific role of programmed cell death 5 in pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling (PubMed:28051100). Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53-mediated signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]; It is implied that overexpression of PDCD5 causes the increase in caspase-3 activity and the subsequent increase of apoptosis in cochlear hair cells and SGNs, and thereby plays a role in the pathogenesis of presbycusis., [RefSeq, PubMed]; May function in the process of apoptosis., [UniProtKB, UniProtKB]; PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision., [RefSeq, PubMed]; Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2., [RefSeq, PubMed]; Serum PDCD5 levels reflect endothelial NO production and are correlated with diabetes mellitus, high-density lipoprotein cholesterol, and coronary calcium, [RefSeq, PubMed]; Suppresses the pathogenicity of transplanted mouse erythroleukemia (MEL) cells in mice., [RefSeq, PubMed]; The expression levels of PDCD5 and caspase 3 in the cochlea of C57 mice increase with age., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008201 heparin binding;GO:0048487 beta-tubulin binding;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P56812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59048-1", "uniprot_id": "PDRG1_MOUSE", "mass": 15382.0, "length": 133, "protein_name": "p53 and DNA damage-regulated protein 1", "gene_name": "Pdrg1", "organism": "Mouse", "refseq_name": "p53 and DNA damage-regulated protein 1 isoform a", "refseq_ac": "NP_849270", "gene_names_uniprotkb": "Pdrg1; Pdrg", "gene_names_refseq": "1110004D19Rik; Pdrg1; Pdrg", "protein_names_uniprotkb": "p53 and DNA damage-regulated protein 1", "protein_names_refseq": "p53 and DNA damage-regulated protein 1 isoform a; p53 and DNA damage-regulated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68559)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14562055;21750661;34428180", "class_list": "", "function": "Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation, [RefSeq, PubMed]; May play a role in chaperone-mediated protein folding., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex;GO:1990062 RPAP3/R2TP/prefoldin-like complex", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9R2-1", "uniprot_id": "OXSR1_MOUSE", "mass": 58214.0, "length": 527, "protein_name": "Serine/threonine-protein kinase OSR1", "gene_name": "Oxsr1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase OSR1", "refseq_ac": "NP_598746", "gene_names_uniprotkb": "Oxsr1; Osr1", "gene_names_refseq": "2210022N24Rik; 2810422B09Rik; Osr1; Oxsr1; mKIAA1101", "protein_names_uniprotkb": "Serine/threonine-protein kinase OSR1; 2.7.11.1; Oxidative stress-responsive 1 protein", "protein_names_refseq": "oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1", "tax_id": 10090, "disease": "", "pathway": " (mmu:108737)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12386165;14707132;15345747;16263722;16382158;17242355;17488636;18800028;19008908;19633012;21183079;21486947;21750661;21972418;23386621;26495903;31219806;33051000;34428180;37507081;37721476", "class_list": "", "function": "Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter., [RefSeq, PubMed]; CircROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis., [RefSeq, PubMed]; Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:12386165, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16382158, PubMed:21972418). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16382158). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:21972418). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (By similarity). Phosphorylates RELL1, RELL2, RELT and PAK1 (By similarity). Phosphorylates PLSCR1 in the presence of RELT (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Phosphorylation states of NCC and OSR1/SPAK (Gene: Oxsr1, GeneID: 108737) were increased by low-salt diets and decreased by high-salt diets, [RefSeq, PubMed]; Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVZ9;Q8C0B9", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1990869 cellular response to chemokine;GO:0007231 osmosensory signaling pathway;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q6P9R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PEM8-1", "uniprot_id": "PCFT_MOUSE", "mass": 50089.0, "length": 459, "protein_name": "Proton-coupled folate transporter", "gene_name": "Slc46a1", "organism": "Mouse", "refseq_name": "proton-coupled folate transporter", "refseq_ac": "NP_081016", "gene_names_uniprotkb": "Slc46a1; D11Ertd18e; Hcp1; Pcft", "gene_names_refseq": "1110002C08Rik; D11Ertd18e; HCP1; Pcft; Slc46a1", "protein_names_uniprotkb": "Proton-coupled folate transporter; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1", "protein_names_refseq": "PCFT/HCP1; heme carrier protein 1; proton-coupled folate transporter", "tax_id": 10090, "disease": "hereditary folate malabsorption (Disease Ontology:DOID:0111678); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:52466); (R-MMU-196757); (R-MMU-917937); (R-MMU-9707616)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16143108;17898134;17962486;19074442;19144319;19349973;21346251;21750661;22058337;32621820;35811443", "class_list": "", "function": "Heme carrier protein 1(HCP 1)is the long-sought intestinal heme transporter and was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency. Its mRNA was expressed in duodenum and regulated by hypoxia, [RefSeq, PubMed]; Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma., [RefSeq, PubMed]; Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17962486). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17962486). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:17962486). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:16143108). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:22058337). Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes., [RefSeq, PubMed]; Slc46a1/PCFT plays critical role in intestinal folate absorption., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q571I8;Q5SYG0;Q8R1H7;Q9D1P1", "ec_number_list": "", "go_molecular_function": "GO:0015350 methotrexate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015232 heme transmembrane transporter activity;GO:0015293 symporter activity;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0055085 transmembrane transport;GO:0015886 heme transport;GO:0015884 folic acid transport;GO:0098838 folate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6PEM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12388-1", "uniprot_id": "PAI2_MOUSE", "mass": 46292.0, "length": 415, "protein_name": "Plasminogen activator inhibitor 2, macrophage", "gene_name": "Serpinb2", "organism": "Mouse", "refseq_name": "plasminogen activator inhibitor 2, macrophage", "refseq_ac": "NP_001167641", "gene_names_uniprotkb": "Serpinb2; Pai2; Planh2", "gene_names_refseq": "PAI-2; Planh2; Serpinb2; ovalbumin", "protein_names_uniprotkb": "Plasminogen activator inhibitor 2, macrophage; PAI-2; Serpin B2", "protein_names_refseq": "plasminogen activator inhibitor 2, macrophage; plasminogen activator inhibitor, type II; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; serine (or cysteine) proteinase inhibitor, clade B, member 2; serpin B2", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831)", "pathway": " (mmu:18788); (R-MMU-75205)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12542794;21750661;2583099;26740625;30084848;34428180;38956496;9892694", "class_list": "", "function": "Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival., [UniProtKB]; SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35687;Q9QWP6;Q9QWP7;Q9QWP8;Q9QWP9;Q9QWQ0;Q9QWZ5;Q9QWZ6", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P12388-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F267-1", "uniprot_id": "P5I13_MOUSE", "mass": 41766.0, "length": 385, "protein_name": "Tumor protein p53-inducible protein 13", "gene_name": "Tp53i13; Trp53i13", "organism": "Mouse", "refseq_name": "tumor protein p53-inducible protein 13 precursor", "refseq_ac": "NP_001020091", "gene_names_uniprotkb": "Tp53i13; Trp53i13; Trp53i13", "gene_names_refseq": "2410019G02Rik; Tp53i13; Trp53i13", "protein_names_uniprotkb": "Tumor protein p53-inducible protein 13", "protein_names_refseq": "tumor protein p53-inducible protein 13 precursor; tumor protein p53-inducible protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:216964)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0009411 response to UV;GO:0009410 response to xenobiotic stimulus;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22777-1", "uniprot_id": "PAI1_MOUSE", "mass": 45170.0, "length": 402, "protein_name": "Plasminogen activator inhibitor 1", "gene_name": "Serpine1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Serpine1; Mr1; Pai1; Planh1", "gene_names_refseq": "", "protein_names_uniprotkb": "Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; PAI-1; PAI; Serpin E1", "protein_names_refseq": "", "tax_id": 10090, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); sleep apnea (Disease Ontology:DOID:0050847); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); ischemic colitis (Disease Ontology:DOID:0060181); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Coronavirus infectious disease (Disease Ontology:DOID:0080599); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); platelet-type bleeding disorder 10 (Disease Ontology:DOID:0111046); pleurisy (Disease Ontology:DOID:10247); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); portal vein thrombosis (Disease Ontology:DOID:11695); diabetic angiopathy (Disease Ontology:DOID:11713); Graves' disease (Disease Ontology:DOID:12361); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); polyneuropathy (Disease Ontology:DOID:1389); thoracic aortic aneurysm (Disease Ontology:DOID:14004); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); toxic shock syndrome (Disease Ontology:DOID:14115); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); retinal vein occlusion (Disease Ontology:DOID:1727); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); neurilemmoma (Disease Ontology:DOID:3192); coronary artery disease (Disease Ontology:DOID:3393); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary fibrosis (Disease Ontology:DOID:3770); placental insufficiency (Disease Ontology:DOID:3891); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); pulmonary hypertension (Disease Ontology:DOID:6432); hematopoietic system disease (Disease Ontology:DOID:74); muscular atrophy (Disease Ontology:DOID:767); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); polycythemia (Disease Ontology:DOID:8432); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947); amyloidosis (Disease Ontology:DOID:9120); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18787); (R-MMU-114608); (R-MMU-3000178); (R-MMU-75205); (R-MMU-9769739)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "16862142;21750661;23291174;2406566;28722352;31219806;34418053;35820727;37828378;7523120;9500522", "class_list": "", "function": "Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 78, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0042583 chromaffin granule", "go_biological_process": "GO:0097187 dentinogenesis;GO:1901331 positive regulation of odontoblast differentiation;GO:0035491 positive regulation of leukotriene production involved in inflammatory response;GO:0061044 negative regulation of vascular wound healing;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P22777-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08675-1", "uniprot_id": "PAR3_MOUSE", "mass": 41697.0, "length": 369, "protein_name": "Proteinase-activated receptor 3", "gene_name": "F2rl2", "organism": "Mouse", "refseq_name": "proteinase-activated receptor 3 precursor", "refseq_ac": "NP_034300", "gene_names_uniprotkb": "F2rl2; Par3", "gene_names_refseq": "F2rl2; F730031A08; PAR3", "protein_names_uniprotkb": "Proteinase-activated receptor 3; Coagulation factor II receptor-like 2; PAR-3; Thrombin receptor-like 2", "protein_names_refseq": "PAR-3; Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2); coagulation factor II receptor-like 2; protease-activated receptor 3; proteinase-activated receptor 3 precursor; proteinase-activated receptor 3; thrombin receptor-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14064); (R-MMU-375276); (R-MMU-416476); (R-MMU-456926)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;16094321;9087410", "class_list": "", "function": "High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EIT2;Q3UXV3", "ec_number_list": "", "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0048018 receptor ligand activity;GO:0001648 proteinase-activated receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007596 blood coagulation;GO:0050708 regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35417-1", "uniprot_id": "PDYN_MOUSE", "mass": 28055.0, "length": 248, "protein_name": "Proenkephalin-B", "gene_name": "Pdyn", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pdyn", "gene_names_refseq": "", "protein_names_uniprotkb": "Proenkephalin-B; Beta-neoendorphin-dynorphin; Dyn-B; Dynorphin B(1-13); Dynorphin B-29; Dynorphin B; Preprodynorphin", "protein_names_refseq": "", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); spinocerebellar ataxia 23 (Disease Ontology:DOID:0050973); withdrawal disorder (Disease Ontology:DOID:0060001); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); opioid abuse (Disease Ontology:DOID:11206); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); temporal lobe epilepsy (Disease Ontology:DOID:3328); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18610); (R-MMU-111885); (R-MMU-202040); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "16292317;21750661;2409273;34203471;9751516", "class_list": "", "function": "Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Leumorphin has a typical opioid activity and may have anti-apoptotic effect., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0005184 neuropeptide hormone activity;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission;GO:0007600 sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88428-1", "uniprot_id": "PAPS2_MOUSE", "mass": 70351.0, "length": 621, "protein_name": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "gene_name": "Papss2", "organism": "Mouse", "refseq_name": "bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 1", "refseq_ac": "NP_035994", "gene_names_uniprotkb": "Papss2; Atpsk2", "gene_names_refseq": "1810018P12Rik; AtpsU2; Atpsk2; Papss2; Sk2; bm", "protein_names_uniprotkb": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; ATP-sulfurylase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase; PAPS synthase 2; PAPSS 2; SAT; SK 2; SK2; Sulfate adenylate transferase; Sulfurylase kinase 2", "protein_names_refseq": "PAPS synthase 2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; brachymorphic; sulfurylase kinase 2", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia, Pakistani type (Disease Ontology:DOID:0050812)", "pathway": " (mmu:23972); (R-MMU-174362)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10559207;21750661;34428180;37507081;9671738;9771708", "class_list": "glycogene", "function": "Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:10559207). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKP4;Q9Z274", "ec_number_list": "2.7.1.25;2.7.7.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0016779 nucleotidyltransferase activity;GO:0004020 adenylylsulfate kinase activity;GO:0004781 sulfate adenylyltransferase (ATP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0007596 blood coagulation;GO:0060348 bone development;GO:0042445 hormone metabolic process;GO:0000103 sulfate assimilation;GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88428-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88634-1", "uniprot_id": "PAR4_MOUSE", "mass": 42786.0, "length": 396, "protein_name": "Proteinase-activated receptor 4", "gene_name": "F2rl3", "organism": "Mouse", "refseq_name": "proteinase-activated receptor 4 preproprotein", "refseq_ac": "NP_032001", "gene_names_uniprotkb": "F2rl3; Par4", "gene_names_refseq": "F2rl3; PAR4", "protein_names_uniprotkb": "Proteinase-activated receptor 4; Coagulation factor II receptor-like 3; PAR-4; Thrombin receptor-like 3", "protein_names_refseq": "PAR-4; coagulation factor II (thrombin) receptor-like 3; coagulation factor II receptor-like 3; proteinase-activated receptor 4 preproprotein; proteinase-activated receptor 4; thrombin receptor-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:14065); (R-MMU-375276); (R-MMU-416476); (R-MMU-456926)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "34428180;38814792;38864771;9716134;9722561", "class_list": "", "function": "Protease activated receptor-4: ready to be part of the antithrombosis spectrum. Review article, [RefSeq, PubMed]; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation., [UniProtKB]; STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3., [RefSeq, PubMed]; This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Mice lacking a functional copy of this gene exhibit impaired platelet activation and prolonged bleeding times. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ77", "ec_number_list": "", "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0002020 protease binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030168 platelet activation;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0070527 platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89084-1", "uniprot_id": "PDE4A_MOUSE", "mass": 93558.0, "length": 844, "protein_name": "3',5'-cyclic-AMP phosphodiesterase 4A", "gene_name": "Pde4a", "organism": "Mouse", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4A isoform 1", "refseq_ac": "NP_062772", "gene_names_uniprotkb": "Pde4a", "gene_names_refseq": "D9Ertd60e; Dpde2; Pde4a", "protein_names_uniprotkb": "3',5'-cyclic-AMP phosphodiesterase 4A; 3.1.4.53; cAMP-specific phosphodiesterase 4A", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4A isoform 1; 3',5'-cyclic-AMP phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase PDE4A; cyclic AMP specific phosphodiesterase PDE4A5A; dunce", "tax_id": 10090, "disease": "brucellosis (Disease Ontology:DOID:11077); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:18577); (R-MMU-180024); (R-MMU-418555)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10602991;11267656;21183079;21750661;34999055;35820727;37735782;9677330", "class_list": "", "function": "Efficiently hydrolyzes cAMP., [UniProtKB, PubMed]; Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes., [UniProtKB, PubMed]; Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration., [RefSeq, PubMed]; Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R078;Q9JHQ4;Q9QX48;Q9QX49;Q9QXI8", "ec_number_list": "3.1.4.-;3.1.4.53;3.1.4.1;3.6.1.9;3.1.4.35;3.1.4.17;3.6.1.25;3.6.1.14", "go_molecular_function": "GO:0030911 TPR domain binding;GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0071466 cellular response to xenobiotic stimulus;GO:0050804 modulation of chemical synaptic transmission;GO:0007608 sensory perception of smell;GO:0006198 cAMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O89084-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10601-1", "uniprot_id": "PAHO_MOUSE", "mass": 11020.0, "length": 100, "protein_name": "Pancreatic polypeptide prohormone", "gene_name": "Ppy", "organism": "Mouse", "refseq_name": "pancreatic polypeptide prohormone precursor", "refseq_ac": "NP_032944", "gene_names_uniprotkb": "Ppy", "gene_names_refseq": "IGSPP; PP; Ppy", "protein_names_uniprotkb": "Pancreatic polypeptide prohormone", "protein_names_refseq": "pancreatic polypeptide prohormone precursor; pancreatic polypeptide prohormone; pancreatic prohormone", "tax_id": 10090, "disease": "", "pathway": " (mmu:19064); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "3343236", "class_list": "", "function": "Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10601-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20033-1", "uniprot_id": "PDGFA_MOUSE", "mass": 24130.0, "length": 211, "protein_name": "Platelet-derived growth factor subunit A", "gene_name": "Pdgfa", "organism": "Mouse", "refseq_name": "platelet-derived growth factor subunit A isoform 1 precursor", "refseq_ac": "NP_032834", "gene_names_uniprotkb": "Pdgfa", "gene_names_refseq": "PDGF-1; Pdgfa", "protein_names_uniprotkb": "Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide", "protein_names_refseq": "PDGF A-chain; PDGF subunit A; platelet-derived growth factor A-chain; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A isoform 1 precursor; platelet-derived growth factor subunit A", "tax_id": 10090, "disease": "oligohydramnios (Disease Ontology:DOID:12215); leiomyoma (Disease Ontology:DOID:127); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); Leydig cell tumor (Disease Ontology:DOID:2696); high grade glioma (Disease Ontology:DOID:3070); pancreatitis (Disease Ontology:DOID:4989); pulmonary hypertension (Disease Ontology:DOID:6432); chronic ulcer of skin (Disease Ontology:DOID:8549)", "pathway": " (mmu:18590); (R-MMU-114608); (R-MMU-1257604); (R-MMU-186763); (R-MMU-186797); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10831606;10903171;11803579;1340209;14514732;15207812;15207813;19030102;2155144;21750661;8681381;9374392;9876175", "class_list": "", "function": "Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005902 microvillus;GO:1990265 platelet-derived growth factor complex;GO:1990270 platelet-derived growth factor receptor-ligand complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0048286 lung alveolus development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P20033-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23440-1", "uniprot_id": "PDE6B_MOUSE", "mass": 98535.0, "length": 856, "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "gene_name": "Pde6b", "organism": "Mouse", "refseq_name": "rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "refseq_ac": "NP_032832", "gene_names_uniprotkb": "Pde6b; Mpb; Pdeb; rd", "gene_names_refseq": "Pde6b; Pdeb; rd-1; rd10; rd1; rd; r", "protein_names_uniprotkb": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; 3.1.4.35; GMP-PDE beta", "protein_names_refseq": "GMP-PDE beta; cGMP-phosphodiesterase beta-subunit; phosphodiesterase, cGMP, rod receptor, beta polypeptide; retinal degeneration 1; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "tax_id": 10090, "disease": "retinitis pigmentosa 40 (Disease Ontology:DOID:0110375); congenital stationary night blindness autosomal dominant 2 (Disease Ontology:DOID:0110863); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:18587); (R-MMU-2485179); (R-MMU-2514859); (R-MMU-4086398)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1656438;1847109;1977087;25613321;30240620", "class_list": "", "function": "Catalytic beta subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity). The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (PubMed:1847109). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (PubMed:30240620)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80UF0", "ec_number_list": "3.1.4.-;3.1.4.35;3.1.4.53;3.6.5.-;3.1.4.17;3.6.1.25;3.6.1.14", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0009583 detection of light stimulus;GO:0007165 signal transduction;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:1990009 retinal cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23440-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30557-1", "uniprot_id": "PE2R3_MOUSE", "mass": 40077.0, "length": 365, "protein_name": "Prostaglandin E2 receptor EP3 subtype", "gene_name": "Ptger3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ptger3; Ptgerep3", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP3 subtype; PGE receptor EP3 subtype; PGE2 receptor EP3 subtype; Prostanoid EP3 receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); membranous glomerulonephritis (Disease Ontology:DOID:10976); leiomyoma (Disease Ontology:DOID:127); renovascular hypertension (Disease Ontology:DOID:1591); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:19218); (R-MMU-391908); (R-MMU-418594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10535876;11535576;1372606;21750661;8223569;8381413;8567630;9751056;9843913", "class_list": "", "function": "Receptor for prostaglandin E2 (PGE2) (PubMed:1372606, PubMed:8223569, PubMed:8381413). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS) (PubMed:9751056). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation (PubMed:11535576). Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration (PubMed:10535876). Not required for normal kidney function, normal urine volume and osmolality (PubMed:9843913)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality., [UniProtKB, UniProtKB]; Receptor for prostaglandin E2 (PGE2); ligand binding activates a signaling cascade via G(i) proteins that leads to inhibition of adenylate cyclase (PubMed:1372606, PubMed:8381413). Shows high agonist-independent constitutive inhibition of adenylate cyclase (PubMed:8223569)., [UniProtKB, PubMed, PubMed, PubMed]; Receptor for prostaglandin E2 (PGE2); ligand binding can activate several distinct signaling cascades, resulting in activation or inhibition of adenylate cyclase., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031965 nuclear membrane;GO:0043025 neuronal cell body;GO:0031526 brush border membrane", "go_biological_process": "GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1904346 positive regulation of gastric mucosal blood circulation;GO:0001660 fever generation;GO:0060455 negative regulation of gastric acid secretion;GO:1903640 negative regulation of gastrin-induced gastric acid secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P30557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30558-1", "uniprot_id": "PAR1_MOUSE", "mass": 47790.0, "length": 430, "protein_name": "Proteinase-activated receptor 1", "gene_name": "F2r", "organism": "Mouse", "refseq_name": "proteinase-activated receptor 1 precursor", "refseq_ac": "NP_034299", "gene_names_uniprotkb": "F2r; Cf2r; Par1", "gene_names_refseq": "Cf2r; F2r; Par1; ThrR", "protein_names_uniprotkb": "Proteinase-activated receptor 1; PAR-1; Thrombin receptor", "protein_names_refseq": "protease-activated receptor 1; proteinase-activated receptor 1 precursor; proteinase-activated receptor 1", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); brain ischemia (Disease Ontology:DOID:2316); brain edema (Disease Ontology:DOID:4724)", "pathway": " (mmu:14062); (R-MMU-375276); (R-MMU-416476); (R-MMU-456926); (R-MMU-9769739)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "19349973;25645137;30084848;31219806;38864289;8678993;8784787", "class_list": "", "function": "Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses., [RefSeq, PubMed]; High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores. The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (PubMed:25645137). May play a role in platelets activation and in vascular development (By similarity). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97507;Q3TVP3", "ec_number_list": "", "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0032795 heterotrimeric G-protein binding", "go_cellular_component": "GO:0031094 platelet dense tubular network;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0032651 regulation of interleukin-1 beta production;GO:1900134 negative regulation of renin secretion into blood stream;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35375-1", "uniprot_id": "PE2R1_MOUSE", "mass": 42966.0, "length": 405, "protein_name": "Prostaglandin E2 receptor EP1 subtype", "gene_name": "Ptger1", "organism": "Mouse", "refseq_name": "prostaglandin E2 receptor EP1 subtype", "refseq_ac": "NP_038669", "gene_names_uniprotkb": "Ptger1; Ptgerep1", "gene_names_refseq": "EP1; Ptger1; Ptgerep1", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP1 subtype; PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor", "protein_names_refseq": "PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor", "tax_id": 10090, "disease": "gastric ulcer (Disease Ontology:DOID:10808)", "pathway": " (mmu:19216); (R-MMU-391908); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;30084848;37531930;7649181;7690750;8858105", "class_list": "", "function": "EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2., [RefSeq, PubMed]; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031748 D1 dopamine receptor binding;GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57722-1", "uniprot_id": "PCBP3_MOUSE", "mass": 39294.0, "length": 371, "protein_name": "Poly(rC)-binding protein 3", "gene_name": "Pcbp3", "organism": "Mouse", "refseq_name": "poly(rC)-binding protein 3 isoform 2", "refseq_ac": "NP_001334145", "gene_names_uniprotkb": "Pcbp3", "gene_names_refseq": "AlphaCP-3; Pcbp3", "protein_names_uniprotkb": "Poly(rC)-binding protein 3; Alpha-CP3", "protein_names_refseq": "alpha-CP3; poly(rC)-binding protein 3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:59093)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10936052;17625070;21750661;22521865;25428506;26740625;30084848;40021952;40885482", "class_list": "", "function": "Represses mu opioid receptor gene promoter at the transcriptional level., [RefSeq, PubMed]; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC., [UniProtKB]; This study demonstrates for the first time that PCBP3 can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSB0;Q8C544", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:1990829 C-rich single-stranded DNA binding;GO:0003723 RNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P57722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70453-1", "uniprot_id": "PDE7A_MOUSE", "mass": 52486.0, "length": 456, "protein_name": "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A", "gene_name": "Pde7a", "organism": "Mouse", "refseq_name": "high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 2", "refseq_ac": "NP_001116231", "gene_names_uniprotkb": "Pde7a", "gene_names_refseq": "Pde7a", "protein_names_uniprotkb": "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A; 3.1.4.53; P2A; cAMP-specific phosphodiesterase 7A", "protein_names_refseq": "cAMP-specific phosphodiesterase 7A; high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 2; high affinity 3',5'-cyclic-AMP phosphodiesterase 7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A", "tax_id": 10090, "disease": "", "pathway": " (mmu:18583); (R-MMU-418555)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11027622;14662840;21750661;23661015;36220621;39283715;8943082", "class_list": "", "function": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:11027622). May have a role in muscle signal transduction (By similarity)., [UniProtKB, PubMed, UniProtKB]; Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice., [RefSeq, PubMed]; PDE7 has roles in regulating oligodendrocyte precursor survival and differentiation during brain development and in adulthood, [RefSeq, PubMed]; PDE7A is not essential for activation of T lymphocytes; its inactivation by targeted gene disruption appears to enhance in vivo humoral immune responses., [RefSeq, PubMed]; Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFY5;Q9ERB3", "ec_number_list": "3.1.4.-;3.1.4.53;3.1.4.1;3.6.1.9;3.1.4.35;3.1.4.17;3.6.1.25;3.6.1.14", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70453-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02242-1", "uniprot_id": "PDCD1_MOUSE", "mass": 31842.0, "length": 288, "protein_name": "Programmed cell death protein 1", "gene_name": "Pdcd1", "organism": "Mouse", "refseq_name": "programmed cell death protein 1 precursor", "refseq_ac": "NP_032824", "gene_names_uniprotkb": "Pdcd1; Pd1", "gene_names_refseq": "Ly101; PD-1; Pdc1; Pdcd1", "protein_names_uniprotkb": "Programmed cell death protein 1; Protein PD-1; mPD-1", "protein_names_refseq": "mPD-1; programmed cell death 1 protein; programmed cell death protein 1 precursor; programmed cell death protein 1; protein PD-1", "tax_id": 10090, "disease": "infantile onset multisystem autoimmune disease 4 (Disease Ontology:DOID:0061163); Cryptococcal meningitis (Disease Ontology:DOID:0080159); lupus nephritis (Disease Ontology:DOID:0080162); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); anogenital venereal wart (Disease Ontology:DOID:11168); hepatitis A (Disease Ontology:DOID:12549); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); dilated cardiomyopathy (Disease Ontology:DOID:12930); toxic shock syndrome (Disease Ontology:DOID:14115); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); hepatitis (Disease Ontology:DOID:2237); pulmonary tuberculosis (Disease Ontology:DOID:2957); lung adenocarcinoma (Disease Ontology:DOID:3910); tuberculosis (Disease Ontology:DOID:399); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:18566); (R-MMU-389948); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10485649;11015443;11209085;11224527;11698646;1396582;15030777;18287011;18641123;21300912;22641383;30487606;9796923", "class_list": "", "function": "Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:10485649, PubMed:11209085, PubMed:11698646, PubMed:21300912). Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:11015443, PubMed:11224527, PubMed:18287011, PubMed:18641123, PubMed:22641383). Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation (PubMed:22641383). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (PubMed:11698646, PubMed:22641383). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0050776 regulation of immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TIU4-1", "uniprot_id": "PDE12_MOUSE", "mass": 67514.0, "length": 608, "protein_name": "2',5'-phosphodiesterase 12", "gene_name": "Pde12", "organism": "Mouse", "refseq_name": "2',5'-phosphodiesterase 12", "refseq_ac": "NP_848783", "gene_names_uniprotkb": "Pde12", "gene_names_refseq": "2'-PDE; 2-PDE; E430028B21Rik; Pde12", "protein_names_uniprotkb": "2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 3.1.13.4; 3.1.4.-; Mitochondrial deadenylase", "protein_names_refseq": "2',5'-phosphodiesterase 12; 2'-phosphodiesterase; mitochondrial deadenylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:211948); (R-MMU-8983711)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "28528544;38325798", "class_list": "", "function": "Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells., [UniProtKB, UniProtKB]; PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTY4;Q6P2L5;Q8BKH8;Q8BTS8;Q8BUQ5", "ec_number_list": "3.1.4.-;3.1.13.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004527 exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0071359 cellular response to dsRNA;GO:0006397 mRNA processing;GO:0071346 cellular response to type II interferon;GO:0045070 positive regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TIU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ULB5-1", "uniprot_id": "PAK6_MOUSE", "mass": 74867.0, "length": 682, "protein_name": "Serine/threonine-protein kinase PAK 6", "gene_name": "Pak6", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PAK 6", "refseq_ac": "NP_001028426", "gene_names_uniprotkb": "Pak6", "gene_names_refseq": "4732456M09; Pak6", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 6; 2.7.11.1; PAK-6; p21-activated kinase 6", "protein_names_refseq": "PAK-6; p21 protein (Cdc42/Rac)-activated kinase 6; p21-activated kinase 6; serine/threonine-protein kinase PAK 6", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:214230); (R-MMU-9013149); (R-MMU-9013407); (R-MMU-9013424)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "18675265;23593460;23710594;26375402;34428180", "class_list": "", "function": "Data suggest that PAK-6 p21-activated kinase plays a role in weight gain unrelated to exercise and caloric intake, [RefSeq, PubMed]; Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice Publication Status: Online-Only, [RefSeq, PubMed]; Our results indicate that Pak5 and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory., [RefSeq, PubMed]; P21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease, [RefSeq, PubMed]; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY26", "ec_number_list": "2.7.11.1;2.7.11.25;2.1.1.13;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;3.6.5.-;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;3.6.5.2;2.7.1.40;2.7.11.21;2.3.1.168;2.7.11.39;3.4.19.12;2.3.1.-;3.1.4.4;3.6.4.6;2.7.10.1;2.7.11.31;1.6.3.-;2.3.2.27;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030054 cell junction;GO:0001650 fibrillar center", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0007626 locomotory behavior;GO:0035556 intracellular signal transduction;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3ULB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BL07-1", "uniprot_id": "PEX1_MOUSE", "mass": 141428.0, "length": 1284, "protein_name": "Peroxisomal ATPase PEX1", "gene_name": "Pex1", "organism": "Mouse", "refseq_name": "peroxisomal ATPase PEX1 isoform 1", "refseq_ac": "NP_001280735", "gene_names_uniprotkb": "Pex1", "gene_names_refseq": "5430414H02Rik; E330005K07Rik; Pex1; ZWS1", "protein_names_uniprotkb": "Peroxisomal ATPase PEX1; 3.6.4.-; Peroxin-1; Peroxisome biogenesis factor 1", "protein_names_refseq": "peroxin-1; peroxisomal ATPase PEX1 isoform 1; peroxisomal ATPase PEX1; peroxisome biogenesis factor 1", "tax_id": 10090, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 1A (Disease Ontology:DOID:0080476); Heimler syndrome 1 (Disease Ontology:DOID:0080623); peroxisome biogenesis disorder 1B (Disease Ontology:DOID:0081240); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (mmu:71382); (R-MMU-9033241)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15328346;15502339;17018057;17242355;18630941;21750661;25428506;26495903;34428180;35979984;36552747", "class_list": "", "function": "Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5., [UniProtKB, UniProtKB]; Crystal structure of pex1, [RefSeq, PubMed]; Functions as a protein unfoldase in peroxisomal biogenesis, using its N-terminal putative adaptor-binding domain, [RefSeq, PubMed]; Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss. Publication Status: Online-Only, [RefSeq, PubMed]; PEX1 is a mediator of alpha1-adrenergic signaling attenuating doxorubicin-induced cardiotoxicity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEC7;Q9CU85", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;2.3.2.27;5.6.2.4;2.3.2.-;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;2.3.2.36;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008289 lipid binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:1904949 ATPase complex", "go_biological_process": "GO:0043335 protein unfolding;GO:0007031 peroxisome organization;GO:0006625 protein targeting to peroxisome;GO:0016558 protein import into peroxisome matrix;GO:0060152 microtubule-based peroxisome localization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5BL07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61194-1", "uniprot_id": "P3C2A_MOUSE", "mass": 190758.0, "length": 1686, "protein_name": "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha", "gene_name": "Pik3c2a", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha", "refseq_ac": "NP_035213", "gene_names_uniprotkb": "Pik3c2a; Cpk", "gene_names_refseq": "Cpk-m; PI3KC2; Pik3c2a", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; 2.7.1.137; 2.7.1.153; 2.7.1.154; Cpk-m; PI3K-C2-alpha; Phosphoinositide 3-kinase-C2-alpha; PtdIns-3-kinase C2 subunit alpha; p170", "protein_names_refseq": "PI3K-C2-alpha; p170; phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphoinositide 3-kinase-C2-alpha; ptdIns-3-kinase C2 subunit alpha", "tax_id": 10090, "disease": "cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18704); (R-MMU-1660499); (R-MMU-1660514); (R-MMU-1660516); (R-MMU-1660517); (R-MMU-432722); (R-MMU-8856828)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10329640;16338929;17114649;20061534;20974805;21750661;22648168;25428506;30059200;30084848;31219806;32782141;33300544;34428180;35822049;36210013;36852467;37827379;38152888;38332727;8662856;8663140", "class_list": "", "function": "Discoidin domain receptor 2 signaling through PIK3C2alpha in fibroblasts promotes lung fibrosis., [RefSeq, PubMed]; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; PI3KC2alpha inhibition is antithrombotic in blood from hypercholesterolemic mice., [RefSeq, PubMed]; PI3KCIIalpha-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61182", "ec_number_list": "2.7.1.153;2.7.1.137;2.7.1.154;3.4.17.22;2.3.2.27;5.6.1.6;3.6.5.2;3.6.5.5;2.7.11.1;3.6.4.10;2.7.10.1;3.1.3.86;3.1.3.56;3.1.3.36;2.7.-.-;2.7.1.151;2.7.1.140;3.1.3.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0030276 clathrin binding;GO:0035091 phosphatidylinositol binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0071583 negative regulation of zinc ion transmembrane transport;GO:0006897 endocytosis;GO:0016477 cell migration;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q61194-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61481-4", "uniprot_id": "PDE1A_MOUSE", "mass": 62347.0, "length": 545, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A", "gene_name": "Pde1a", "organism": "Mouse", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7", "refseq_ac": "NP_001009978", "gene_names_uniprotkb": "Pde1a", "gene_names_refseq": "Pde1a", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; 3.1.4.17; 61 kDa Cam-PDE; Cam-PDE 1A", "protein_names_refseq": "61 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; cam-PDE 1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:18573); (R-MMU-111957); (R-MMU-418457); (R-MMU-418555)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;15901640;31131329", "class_list": "", "function": "Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP., [UniProtKB, PubMed]; New variant PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function., [RefSeq, PubMed]; PDE1 inhibition induces PKA- and PKG-mediated promotion of proteasomal degradation of misfolded proteins and treats heart failure with preserved ejection fraction caused by CryAB(R120G) in a mouse model of cardiac proteinopathy Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9688, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q6V1;O35388;Q5I7S8;Q8BRR9;Q9JLL9", "ec_number_list": "3.1.4.-;3.1.4.53;3.1.4.35;3.1.4.1;3.6.1.9;3.1.4.17;3.6.1.25;3.6.1.14", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0031514 motile cilium;GO:0043025 neuronal cell body;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007165 signal transduction;GO:0048660 regulation of smooth muscle cell proliferation;GO:0034391 regulation of smooth muscle cell apoptotic process;GO:0046069 cGMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61481-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61907-1", "uniprot_id": "PEMT_MOUSE", "mass": 22579.0, "length": 199, "protein_name": "Phosphatidylethanolamine N-methyltransferase", "gene_name": "Pemt", "organism": "Mouse", "refseq_name": "phosphatidylethanolamine N-methyltransferase isoform a", "refseq_ac": "NP_001276940", "gene_names_uniprotkb": "Pemt; Pempt; Pemt2", "gene_names_refseq": "PEAMT; PEMT2; PLMT; Pempt2; Pempt; Pemt", "protein_names_uniprotkb": "Phosphatidylethanolamine N-methyltransferase; 2.1.1.17; 2.1.1.71; PEAMT; PEMT; PLMT; Phospholipid methyltransferase", "protein_names_refseq": "phosphatidylethanolamine N-methyltransferase isoform a; phospholipid methyltransferase", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508)", "pathway": " (mmu:18618); (R-MMU-1483191)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12482759;21750661;30084848;34428180;36139111;38069170;8978486;9371769;9765216", "class_list": "", "function": "Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (Probable) (PubMed:9371769). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step (PubMed:9371769)., [UniProtKB, PubMed, PubMed]; Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of Phosphatidylethanolamine N-Methyltransferase (PEMT) and Its Waist-Hip-Ratio-Associated Locus rs4646404 in Obesity-Related Metabolic Traits and Liver Disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZN8;Q7TNW6;Q8R0I1", "ec_number_list": "2.1.1.17;2.1.1.71", "go_molecular_function": "GO:0008429 phosphatidylethanolamine binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity;GO:0004608 phosphatidylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0033273 response to vitamin;GO:0006686 sphingomyelin biosynthetic process;GO:0050747 positive regulation of lipoprotein metabolic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61907-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61990-1", "uniprot_id": "PCBP2_MOUSE", "mass": 38222.0, "length": 362, "protein_name": "Poly(rC)-binding protein 2", "gene_name": "Pcbp2", "organism": "Mouse", "refseq_name": "poly(rC)-binding protein 2 isoform 1", "refseq_ac": "NP_001096635", "gene_names_uniprotkb": "Pcbp2; Cbp; Hnrnpx; Hnrpx", "gene_names_refseq": "Hnrpx; Pcbp2; alphaCP-2", "protein_names_uniprotkb": "Poly(rC)-binding protein 2; Alpha-CP2; CBP; CTBP; Putative heterogeneous nuclear ribonucleoprotein X; hnRNP X", "protein_names_refseq": "CBP; CTBP; alpha-CP2; hnRNP X; poly(rC)-binding protein 2 isoform 1; putative heterogeneous nuclear ribonucleoprotein X", "tax_id": 10090, "disease": "", "pathway": " (mmu:18521); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10936052;21750661;22645316;25153642;25605945;26527618;29187734;33300544;33725478;34180713;34904931;37453647;39627609;8208614;8367306", "class_list": "", "function": "Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells., [RefSeq, PubMed]; RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis., [RefSeq, PubMed]; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:8208614, PubMed:8367306). Major cellular poly(rC)-binding protein (By similarity). Also binds poly(rU) (By similarity). Acts as a negative regulator of antiviral signaling (By similarity). Negatively regulates cellular antiviral responses mediated by MAVS signaling (By similarity). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (By similarity). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (By similarity). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (PubMed:34180713)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61383;Q62042", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q61990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62053-1", "uniprot_id": "PE2R2_MOUSE", "mass": 40479.0, "length": 362, "protein_name": "Prostaglandin E2 receptor EP2 subtype", "gene_name": "Ptger2", "organism": "Mouse", "refseq_name": "prostaglandin E2 receptor EP2 subtype", "refseq_ac": "NP_032990", "gene_names_uniprotkb": "Ptger2; Ptgerep2", "gene_names_refseq": "EP2; Ptger2; Ptgerep2", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP2 subtype; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostanoid EP2 receptor", "protein_names_refseq": "PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (EP2 subtype); prostaglandin E receptor EP2 subtype; prostaglandin E receptor subtype EP2; prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor", "tax_id": 10090, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); asthma, nasal polyps, and aspirin intolerance (Disease Ontology:DOID:0111579); heart disease (Disease Ontology:DOID:114); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung squamous cell carcinoma (Disease Ontology:DOID:3907)", "pathway": " (mmu:19217); (R-MMU-391908); (R-MMU-418555)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "7556658", "class_list": "", "function": "Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1904346 positive regulation of gastric mucosal blood circulation;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62053-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64GA5-1", "uniprot_id": "PA24C_MOUSE", "mass": 67882.0, "length": 597, "protein_name": "Cytosolic phospholipase A2 gamma", "gene_name": "Pla2g4c", "organism": "Mouse", "refseq_name": "cytosolic phospholipase A2 gamma isoform 2", "refseq_ac": "NP_001004762", "gene_names_uniprotkb": "Pla2g4c", "gene_names_refseq": "D7Ertd445e; Pla2g4c", "protein_names_uniprotkb": "Cytosolic phospholipase A2 gamma; 2.3.1.-; 3.1.1.4; 3.1.1.5; Cytosolic lysophospholipase; Cytosolic lysophospholipid O-acyltransferase; Phospholipase A2 group IVC; cPLA2-gamma", "protein_names_refseq": "CPLA2-gamma; cytosolic lysophospholipase; cytosolic lysophospholipid O-acyltransferase; cytosolic phospholipase A2 gamma isoform 2; cytosolic phospholipase A2 gamma; egg and early embryo abundant protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:232889); (R-MMU-1482788); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1483115); (R-MMU-1483152)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "15950603;17213206;20452986;20817734;22082005;30161143", "class_list": "", "function": "CPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia, [RefSeq, PubMed]; Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles. Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at the sn-1 position of lysophospholipids. Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency., [UniProtKB, UniProtKB]; Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation., [RefSeq, PubMed]; IPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts, [RefSeq, PubMed]; Results link cytokine-mediated alterations in cPLA2gamma gene expression with allergic asthma and outline a complex regulatory mechanism, [RefSeq, PubMed]; Validation of differentially expressed genes (DEGs) by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. A 24-h incubation of BSM tissues with PGD2 caused a hyperresponsiveness to acetylcholine in naive control mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EC7;Q3UWS1;Q7TN01", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.43;3.1.1.32;3.1.1.3;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;2.3.1.149;2.3.1.51;3.1.4.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005811 lipid droplet;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0046475 glycerophospholipid catabolic process;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64GA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUB0-1", "uniprot_id": "HOIL1_MOUSE", "mass": 57534.0, "length": 508, "protein_name": "RanBP-type and C3HC4-type zinc finger-containing protein 1", "gene_name": "Rbck1", "organism": "Mouse", "refseq_name": "ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a", "refseq_ac": "NP_001077390", "gene_names_uniprotkb": "Rbck1; Rbck; Ubce7ip3; Uip28", "gene_names_refseq": "HOIL-1L; HOIL-1; Rbck1; UIP28; Ubce7ip3", "protein_names_uniprotkb": "RanBP-type and C3HC4-type zinc finger-containing protein 1; 2.3.2.31; HOIL-1; Heme-oxidized IRP2 ubiquitin ligase 1 homolog; RING-type E3 ubiquitin transferase HOIL-1; UbcM4-interacting protein 28; Ubiquitin-conjugating enzyme 7-interacting protein 3", "protein_names_refseq": "RING-type E3 ubiquitin transferase HOIL-1; heme-oxidized IRP2 ubiquitin ligase 1 homolog; novel zinc finger, C3HC4 type (RING finger) protein; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a; ranBP-type and C3HC4-type zinc finger-containing protein 1; ubcM4-interacting protein 28; ubiquitin-conjugating enzyme 7-interacting protein 3", "tax_id": 10090, "disease": "glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:24105); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-983168)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10431818;17947660;19136968;20956555;21750661;22139374;37902285;37976837;38632277", "class_list": "", "function": "E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types., [UniProtKB, UniProtKB]; HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes. Erratum:[Sci Rep. 2024 May 6;14(1):10331. doi: 10.1038/s41598-024-61046-x. PMID: 38710811] Publication Status: Online-Only, [RefSeq, PubMed]; HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection., [RefSeq, PubMed]; Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANR4;Q3TM86;Q8C2I0", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;3.4.19.12;2.3.2.-;3.6.4.-;2.7.11.10;2.7.11.1;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.25;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0003690 double-stranded DNA binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0071797 LUBAC complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WA6-1", "uniprot_id": "SHRPN_MOUSE", "mass": 39852.0, "length": 380, "protein_name": "Sharpin", "gene_name": "Sharpin", "organism": "Mouse", "refseq_name": "sharpin", "refseq_ac": "NP_079616", "gene_names_uniprotkb": "Sharpin; Cpdm; Sipl1", "gene_names_refseq": "0610041B22Rik; RBCKL1; SIPL1; Sharpin; cpdm", "protein_names_uniprotkb": "Sharpin; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; mSIPL1", "protein_names_refseq": "mSIPL1; protein kinase C-interacting protein RBCC like 1; shank-associated RH domain-interacting protein; shank-interacting protein-like 1; sharpin", "tax_id": 10090, "disease": "atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:106025); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12753155;17538631;19650867;20811394;20956555;21069580;21455173;21455180;21455181;21750661;21913724;37976837", "class_list": "", "function": "Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNT3;Q8CHL3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0071797 LUBAC complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:2000348 regulation of CD40 signaling pathway;GO:0031424 keratinization;GO:0008544 epidermis development;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91WA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62231-1", "uniprot_id": "SIX1_MOUSE", "mass": 32210.0, "length": 284, "protein_name": "Homeobox protein SIX1", "gene_name": "Six1", "organism": "Mouse", "refseq_name": "homeobox protein SIX1", "refseq_ac": "NP_033215", "gene_names_uniprotkb": "Six1", "gene_names_refseq": "Six1", "protein_names_uniprotkb": "Homeobox protein SIX1; Sine oculis homeobox homolog 1", "protein_names_refseq": "homeobox protein SIX1; sine oculis homeobox homolog 1; sine oculis-related homeobox 1 homolog", "tax_id": 10090, "disease": "branchiootic syndrome 3 (Disease Ontology:DOID:0061210); autosomal dominant nonsyndromic deafness 23 (Disease Ontology:DOID:0110553); branchiootorenal syndrome (Disease Ontology:DOID:14702); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); neurilemmoma (Disease Ontology:DOID:3192); ovarian carcinoma (Disease Ontology:DOID:4001); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:20471)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11978764;12215533;12668636;12783782;12834866;14628042;14695375;15141091;16488997;21884692;25428506;27923061;38422767;7720577;9826681", "class_list": "", "function": "MiR-128-3p alleviates airway inflammation in asthma by targeting SIX1 to regulate mitochondrial fission and fusion., [RefSeq, PubMed]; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (PubMed:12215533, PubMed:12668636, PubMed:12834866, PubMed:14628042, PubMed:14695375). Plays an important role in the development of several organs, including kidney, muscle and inner ear (PubMed:12668636, PubMed:12783782, PubMed:12834866, PubMed:14628042, PubMed:14695375). Depending on context, functions as a transcriptional repressor or activator (PubMed:14628042). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR (PubMed:16488997). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (PubMed:11978764). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (PubMed:14628042). During myogenesis, seems to act together with EYA2 and DACH2. Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation (PubMed:27923061)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIL7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0001759 organ induction;GO:0050678 regulation of epithelial cell proliferation;GO:0086100 endothelin receptor signaling pathway;GO:0061055 myotome development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63028-1", "uniprot_id": "TCTP_MOUSE", "mass": 19462.0, "length": 172, "protein_name": "Translationally-controlled tumor protein", "gene_name": "Tpt1", "organism": "Mouse", "refseq_name": "translationally-controlled tumor protein isoform 1", "refseq_ac": "NP_033455", "gene_names_uniprotkb": "Tpt1; Trt", "gene_names_refseq": "TCTP; Tpt1; Trt; p21; p23", "protein_names_uniprotkb": "Translationally-controlled tumor protein; 21 kDa polypeptide; TCTP; p21; p23", "protein_names_refseq": "21 kDa polypeptide under translational control; fortilin; translationally regulated transcript (21 kDa); translationally-controlled tumor protein isoform 1; translationally-controlled tumor protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:22070)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12782126;21183079;21750661;22645316;2479380;28135057;28528544;3357792;34407217;34428180;35562118;35622214;37453647;37507081", "class_list": "", "function": "Involved in calcium binding and microtubule stabilization (By similarity). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity)., [UniProtKB, UniProtKB]; Involved in calcium binding and microtubule stabilization. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein., [UniProtKB, UniProtKB]; TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes., [RefSeq, PubMed]; TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF)., [RefSeq, PubMed]; Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite Leishmania donovani., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P14701;Q3TMT0;Q3TWS8;Q3TWX0;Q3UAG7;Q569M9", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009615 response to virus;GO:0019827 stem cell population maintenance;GO:2000384 negative regulation of ectoderm development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P63028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC98-1", "uniprot_id": "PKHA4_MOUSE", "mass": 64839.0, "length": 588, "protein_name": "Pleckstrin homology domain-containing family A member 4", "gene_name": "Plekha4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Plekha4; Pepp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 4; PEPP-1; PH domain-containing family A member 4; Phosphoinositol 3-phosphate-binding protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:69217); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3N3", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VC98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWR2-1", "uniprot_id": "PITH1_MOUSE", "mass": 24192.0, "length": 211, "protein_name": "PITH domain-containing protein 1", "gene_name": "Pithd1", "organism": "Mouse", "refseq_name": "PITH domain-containing protein 1", "refseq_ac": "NP_079687", "gene_names_uniprotkb": "Pithd1; 1110049F12Rik; Trp26", "gene_names_refseq": "1110049F12Rik; Pithd1; Trp26", "protein_names_uniprotkb": "PITH domain-containing protein 1", "protein_names_refseq": "AD039; PITH domain-containing protein 1; thioredoxin family Trp26", "tax_id": 10090, "disease": "", "pathway": " (mmu:66193)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25134913;31915251;35820727", "class_list": "", "function": "PITHD1 is a proteasome-interacting protein essential for male fertilization., [RefSeq, PubMed]; Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMZ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007286 spermatid development;GO:0045893 positive regulation of DNA-templated transcription;GO:0007341 penetration of zona pellucida;GO:0045654 positive regulation of megakaryocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BWR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35464-1", "uniprot_id": "SEM6A_MOUSE", "mass": 114433.0, "length": 1031, "protein_name": "Semaphorin-6A", "gene_name": "Sema6a", "organism": "Mouse", "refseq_name": "semaphorin-6A isoform 2 precursor", "refseq_ac": "NP_001298026", "gene_names_uniprotkb": "Sema6a; Semaq", "gene_names_refseq": "A730020P05Rik; Sema6A-1; Sema6a; Semaq; VIa", "protein_names_uniprotkb": "Semaphorin-6A; SEMA6A-1; Sema Q; Sema VIA; Semaphorin Q; Semaphorin VIA; Semaphorin-6A-1", "protein_names_refseq": "Mutant line 997; sema Q; sema VIA; semaphorin Q; semaphorin VIA; semaphorin-6A isoform 2 precursor; semaphorin-6A-1; semaphorin-6A", "tax_id": 10090, "disease": "", "pathway": " (mmu:20358)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10993894;16205717;19063725;20877282;20881961;21750661;25428506;30899004;34203471;34428180;9204478", "class_list": "", "function": "Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5A8;Q6PCN9;Q9EQ71", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030215 semaphorin receptor binding;GO:0042802 identical protein binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0071526 semaphorin-plexin signaling pathway;GO:0001764 neuron migration;GO:0006915 apoptotic process;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O35464-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDD9-1", "uniprot_id": "PHIP_MOUSE", "mass": 206726.0, "length": 1821, "protein_name": "PH-interacting protein", "gene_name": "Phip", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Phip; Ndrp; Phip1; Wdr11", "gene_names_refseq": "", "protein_names_uniprotkb": "PH-interacting protein; IRS-1 PH domain-binding protein; NDRP; Neuronal differentiation-related protein; PHIP; WD repeat-containing protein 11", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:83946); (R-MMU-9013418)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11018022;11098134;12242307;17242355;17636024;19144319;21183079;21750661;23806337;25428506;28528544;31219806;31599954;34428180;40885482", "class_list": "", "function": "Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS96;Q80VI6;Q9EPY1;Q9ESL6", "ec_number_list": "", "go_molecular_function": "GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010800 positive regulation of peptidyl-threonine phosphorylation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0040008 regulation of growth", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8VDD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZL7-1", "uniprot_id": "RGF1B_MOUSE", "mass": 55273.0, "length": 473, "protein_name": "Ras-GEF domain-containing family member 1B", "gene_name": "Rasgef1b", "organism": "Mouse", "refseq_name": "ras-GEF domain-containing family member 1B isoform 1", "refseq_ac": "NP_665838", "gene_names_uniprotkb": "Rasgef1b; Gpig4", "gene_names_refseq": "4732452O09Rik; GPIgamma4; Gpig4; Rasgef1b", "protein_names_uniprotkb": "Ras-GEF domain-containing family member 1B; GPI gamma-4", "protein_names_refseq": "GPI-gamma 4; ras-GEF domain-containing family member 1B isoform 1; ras-GEF domain-containing family member 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:320292)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12488504;20090772;21750661;25428506;30084848;30779550;31219806;31599954;34203471;34428180;34438395;36210013;37950057;38048936", "class_list": "", "function": "Behavioral, neurochemical and neuroimmune features of RasGEF1b deficient mice., [RefSeq, PubMed]; Circ_RASGEF1B Promotes LPS-Induced Apoptosis and Inflammatory Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in Septic Acute Kidney Injury Cell Model., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro)., [UniProtKB, PubMed]; Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Upon toll-like receptor activation, RasGEF1b may trigger Ras-like proteins and regulate specific biological activities of macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F5H8M5;Q3UE12;Q8C189", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005770 late endosome;GO:0030496 midbody", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8JZL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TF3-1", "uniprot_id": "PCD19_MOUSE", "mass": 126035.0, "length": 1145, "protein_name": "Protocadherin-19", "gene_name": "Pcdh19", "organism": "Mouse", "refseq_name": "protocadherin-19 isoform a precursor", "refseq_ac": "NP_001098715", "gene_names_uniprotkb": "Pcdh19; Kiaa1313", "gene_names_refseq": "B530002L05Rik; Gm717; Pcdh19; mKIAA1313", "protein_names_uniprotkb": "Protocadherin-19", "protein_names_refseq": "protocadherin-19 isoform a precursor", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 9 (Disease Ontology:DOID:0060848)", "pathway": " (mmu:279653)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16682261;21750661;25428506;30084848;30899004;34428180;36997609;37828378;38454084", "class_list": "", "function": "Calcium-dependent cell-adhesion protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression., [RefSeq, PubMed]; Pcdh19 gene is developmentally regulated during mouse organogenesis and shows a unique expression profile among protocadherins., [RefSeq, PubMed]; Proteomic analysis of the developing mammalian brain links PCDH19 to the Wnt/beta-catenin signalling pathway., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2AGW3;Q8BL13", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80TF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2V1-1", "uniprot_id": "PP4R1_MOUSE", "mass": 106298.0, "length": 951, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "gene_name": "Ppp4r1", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b", "refseq_ac": "NP_001107603", "gene_names_uniprotkb": "Ppp4r1", "gene_names_refseq": "3110001J10Rik; Pp4r1; Ppp4r1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "protein_names_refseq": "serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b; serine/threonine-protein phosphatase 4 regulatory subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70351)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;27507813;28135057;30132533;34203471;34428180;37739270;38424148", "class_list": "", "function": "AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner., [RefSeq, PubMed]; LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function., [RefSeq, PubMed]; MiR3383p may be involved in TNFalphamediated gluconeogenesis via targeting of PP4R1 in hepatocytes., [RefSeq, PubMed]; PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress., [RefSeq, PubMed]; Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0R8", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030289 protein phosphatase 4 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K2V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35316-1", "uniprot_id": "SC6A6_MOUSE", "mass": 69856.0, "length": 621, "protein_name": "Sodium- and chloride-dependent taurine transporter", "gene_name": "Slc6a6", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent taurine transporter isoform a", "refseq_ac": "NP_033346", "gene_names_uniprotkb": "Slc6a6; Taut", "gene_names_refseq": "Slc6a6; Taut", "protein_names_uniprotkb": "Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6; TauT; Taurine transporter", "protein_names_refseq": "sodium- and chloride-dependent taurine transporter isoform a; sodium- and chloride-dependent taurine transporter; solute carrier family 6 member 6; taurine/beta-alanine transporter", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (mmu:21366); (R-MMU-352230)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11772953;1465453;14734644;15149840;16421246;21750661;22896705;25428506;28528544;30084848;30270321;30862735;31219806;31599954;34428180;37289866;37561545;40601627;9375654", "class_list": "", "function": "Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6., [RefSeq, PubMed]; Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:1465453, PubMed:30270321, PubMed:37289866, PubMed:40601627, PubMed:9375654). Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (PubMed:37289866). In addition to mediate extracellular taurine uptake, also able to mediate transport of taurine into mitochondria, sustaining mitochondrial translation (By similarity). Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:1465453, PubMed:30270321, PubMed:9375654)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P31642;Q91WI2", "ec_number_list": "", "go_molecular_function": "GO:0030977 taurine binding;GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0005369 taurine:sodium symporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032328 alanine transport;GO:0045597 positive regulation of cell differentiation;GO:0006865 amino acid transport;GO:0050804 modulation of chemical synaptic transmission;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O35316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6W3F0-1", "uniprot_id": "P4HA3_MOUSE", "mass": 60975.0, "length": 542, "protein_name": "Prolyl 4-hydroxylase subunit alpha-3", "gene_name": "P4ha3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "P4ha3", "gene_names_refseq": "", "protein_names_uniprotkb": "Prolyl 4-hydroxylase subunit alpha-3; 1.14.11.2; 4-PH alpha-3; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:320452)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14500733;21750661", "class_list": "", "function": "Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q640R2;Q8C3A6", "ec_number_list": "1.14.11.2", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity;GO:0051213 dioxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6W3F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62177-1", "uniprot_id": "SEM3B_MOUSE", "mass": 82700.0, "length": 748, "protein_name": "Semaphorin-3B", "gene_name": "Sema3b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sema3b; Semaa; Sema", "gene_names_refseq": "", "protein_names_uniprotkb": "Semaphorin-3B; Sema A; Semaphorin-A", "protein_names_refseq": "", "tax_id": 10090, "disease": "substance abuse (Disease Ontology:DOID:302)", "pathway": " (mmu:20347)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34418053;7748561", "class_list": "", "function": "Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9Q9Q1", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62177-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88561-1", "uniprot_id": "S27A3_MOUSE", "mass": 72965.0, "length": 667, "protein_name": "Long-chain fatty acid transport protein 3", "gene_name": "Slc27a3", "organism": "Mouse", "refseq_name": "long-chain fatty acid transport protein 3 isoform 2", "refseq_ac": "NP_001303617", "gene_names_uniprotkb": "Slc27a3; Acsvl3; Fatp3", "gene_names_refseq": "Acsvl3; FATP-3; FATP3; Slc27a3; Vlcs-3", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 3; 6.2.1.-; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; FATP-3; Fatty acid transport protein 3; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 3; VLCS-3; Very long-chain acyl-CoA synthetase homolog 3", "protein_names_refseq": "arachidonate--CoA ligase; long-chain fatty acid transport protein 3 isoform 2; long-chain fatty acid transport protein 3; long-chain-fatty-acid--CoA ligase; mFLJ00207 protein; solute carrier family 27 member 3; very long-chain acyl-CoA synthetase homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:26568)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15469937;15699031;20603810;21750661;23936004;34428180;9671728", "class_list": "", "function": "Analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle Publication Status: Online-Only, [RefSeq, PubMed]; Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:15469937, PubMed:15699031). Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes (PubMed:15699031)., [UniProtKB, PubMed, PubMed]; Studies cast doubt on the designation of very long-chain acyl-CoA synthetase 3 (ACSVL3) as a fatty acid transport protein, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAU1;Q8BK70", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15;6.2.1.7;6.2.1.24;6.2.1.76;6.2.1.2;6.2.1.25", "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0004321 fatty-acyl-CoA synthase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0015908 fatty acid transport;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCX2-1", "uniprot_id": "S35H1_MOUSE", "mass": 40302.0, "length": 364, "protein_name": "Solute carrier family 35 member H1", "gene_name": "Slc35c2; Slc35h1", "organism": "Mouse", "refseq_name": "solute carrier family 35 member H1 isoform 1", "refseq_ac": "NP_001239502", "gene_names_uniprotkb": "Slc35c2; Slc35h1; Ovcov1; Slc35c2", "gene_names_refseq": "CGI-15; D2Wsu58e; Ovcov1; Slc35c2; Slc35h1", "protein_names_uniprotkb": "Solute carrier family 35 member H1; Ovarian cancer-overexpressed gene 1 protein; Solute carrier family 35 member C2", "protein_names_refseq": "ovarian cancer overexpressed gene 1 protein; solute carrier family 35 member H1 isoform 1; solute carrier family 35, member C2", "tax_id": 10090, "disease": "", "pathway": " (mmu:228875)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12461647;19144319;20837470;21183079;21750661;30084848;35820727;38270391", "class_list": "glycogene", "function": "Data show that Slc35c2 enhances fucosylation of Notch1., [RefSeq, PubMed]; Putative GDP-fucose transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005801 cis-Golgi network;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0045747 positive regulation of Notch signaling pathway;GO:0036066 protein O-linked glycosylation via fucose;GO:0015786 UDP-glucose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAX2-1", "uniprot_id": "PLPP2_MOUSE", "mass": 31193.0, "length": 276, "protein_name": "Phospholipid phosphatase 2", "gene_name": "Plpp2", "organism": "Mouse", "refseq_name": "phospholipid phosphatase 2 isoform 2", "refseq_ac": "NP_001289318", "gene_names_uniprotkb": "Plpp2; Lpp2; Ppap2c", "gene_names_refseq": "Lpp2; PAP2-G; PAP2-gamma; PAP2c; Plpp2; Ppap2c", "protein_names_uniprotkb": "Phospholipid phosphatase 2; 3.1.3.-; 3.1.3.4; Lipid phosphate phosphohydrolase 2; PAP-2c; PAP2-G; PAP2-gamma; PAP2c; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c", "protein_names_refseq": "lipid phosphate phosphohydrolase 2; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphatase 2c; phosphatidic acid phosphatase type 2C; phospholipid phosphatase 2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:50784); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10662554;10992322;19656770;21750661", "class_list": "glycogene", "function": "Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUA4", "ec_number_list": "3.1.3.4;3.6.1.75;3.1.3.-;3.1.3.106;3.6.1.-;3.6.1.68", "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0006672 ceramide metabolic process;GO:0006644 phospholipid metabolic process;GO:1902806 regulation of cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DAX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ36-1", "uniprot_id": "RINT1_MOUSE", "mass": 90094.0, "length": 792, "protein_name": "RAD50-interacting protein 1", "gene_name": "Rint1", "organism": "Mouse", "refseq_name": "RAD50-interacting protein 1 isoform 2", "refseq_ac": "NP_001297396", "gene_names_uniprotkb": "Rint1", "gene_names_refseq": "1500019C06Rik; 2810450M21Rik; Rint-1; Rint1", "protein_names_uniprotkb": "RAD50-interacting protein 1; RAD50 interactor 1; RINT-1", "protein_names_refseq": "RAD50-interacting protein 1 isoform 2; RAD50-interacting protein 1", "tax_id": 10090, "disease": "infantile liver failure syndrome (Disease Ontology:DOID:0080716)", "pathway": " (mmu:72772); (R-MMU-6811434)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17470549;21750661;25428506;25605945;26383973;27367497;28264000;30084848;34203471;34428180", "class_list": "", "function": "A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy., [RefSeq, PubMed]; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control (By similarity)., [UniProtKB, UniProtKB]; RINT1 has a role as a multitasking protein with roles in genomic stability, ER homeostasis, and autophagy, [RefSeq, PubMed]; These data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXS1;Q6P1I2;Q8C193", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0070939 Dsl1/NZR complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BZ36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RTL5-1", "uniprot_id": "RSRC2_MOUSE", "mass": 43876.0, "length": 376, "protein_name": "Arginine/serine-rich coiled-coil protein 2", "gene_name": "Rsrc2", "organism": "Mouse", "refseq_name": "arginine/serine-rich coiled-coil protein 2 isoform 1", "refseq_ac": "NP_001005525", "gene_names_uniprotkb": "Rsrc2", "gene_names_refseq": "1500011J06Rik; Rsrc2", "protein_names_uniprotkb": "Arginine/serine-rich coiled-coil protein 2", "protein_names_refseq": "arginine/serine-rich coiled-coil protein 2 isoform 1; arginine/serine-rich coiled-coil protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:208606)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2RTL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TQR0-1", "uniprot_id": "PGAP2_MOUSE", "mass": 29446.0, "length": 254, "protein_name": "Acyltransferase PGAP2", "gene_name": "Pgap2", "organism": "Mouse", "refseq_name": "acyltransferase PGAP2 isoform 1", "refseq_ac": "NP_001278287", "gene_names_uniprotkb": "Pgap2; Frag1", "gene_names_refseq": "1810006G21Rik; Frag1; Pgap2; clpex", "protein_names_uniprotkb": "Acyltransferase PGAP2; 2.3.-.-; FGF receptor-activating protein 1; Post-GPI attachment to proteins factor 2", "protein_names_refseq": "FGF receptor activating protein 1; acyltransferase PGAP2 isoform 1; acyltransferase PGAP2; post-GPI attachment to proteins factor 2", "tax_id": 10090, "disease": "hyperphosphatasia with impaired intellectual development syndrome 3 (Disease Ontology:DOID:0070435)", "pathway": " (mmu:233575)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15983387;17761529;21750661;31232685;34428180;37185241", "class_list": "", "function": "Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the second step of the fatty acid remodeling, by reacylating a lyso-GPI intermediate at sn-2 of inositol phosphate by a saturated chain. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala. Publication Status: Online-Only, [RefSeq, PubMed]; The Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis., [RefSeq, PubMed]; The authors identified a novel mouse mutant (cleft lip/palate, edema and exencephaly; Clpex) with a hypo-morphic mutation in Post-Glycophosphatidylinositol Attachment to Proteins-2 (Pgap2), a component of the GPI biosynthesis pathway. The Clpex mutation decreases surface GPI expression. They found that the Clpex phenotype is due to apoptosis of neural crest cells (NCCs) and the cranial neuroepithelium. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVW2;Q3U814;Q3UJI0;Q99KA1", "ec_number_list": "2.3.-.-", "go_molecular_function": "GO:0016740 transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TQR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXR6-1", "uniprot_id": "PELI3_MOUSE", "mass": 48168.0, "length": 445, "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3", "gene_name": "Peli3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase pellino homolog 3 isoform 1", "refseq_ac": "NP_766423", "gene_names_uniprotkb": "Peli3", "gene_names_refseq": "6030441F14Rik; A930011L17; Peli3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase pellino homolog 3; 2.3.2.27; Pellino-3", "protein_names_refseq": "E3 ubiquitin-protein ligase pellino homolog 3 isoform 1; E3 ubiquitin-protein ligase pellino homolog 3; RING-type E3 ubiquitin transferase pellino homolog 3; protein pellino homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:240518); (R-MMU-9020702); (R-MMU-937039); (R-MMU-975144)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;23042151;23892723;24113711;37341064", "class_list": "", "function": "E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation., [RefSeq, PubMed]; Pellino 3 promotes the colitis-associated colorectal cancer through suppression of IRF4-mediated negative regulation of TLR4 signalling., [RefSeq, PubMed]; Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha., [RefSeq, PubMed]; Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K329", "ec_number_list": "2.3.2.23;2.7.11.1;2.3.2.27", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BXR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU28-1", "uniprot_id": "PFD5_MOUSE", "mass": 17356.0, "length": 154, "protein_name": "Prefoldin subunit 5", "gene_name": "Pfdn5", "organism": "Mouse", "refseq_name": "prefoldin subunit 5", "refseq_ac": "NP_081320", "gene_names_uniprotkb": "Pfdn5; Eig1; Mm1; Pfd5", "gene_names_refseq": "1190001O17Rik; 1700010A06Rik; D15Ertd697e; Eig1; MM-1; Pfdn5", "protein_names_uniprotkb": "Prefoldin subunit 5; EIG-1; Myc modulator 1; c-Myc-binding protein Mm-1", "protein_names_refseq": "C-myc-binding protein Mm-1; EIG-1; c-myc binding protein MM-1; myc modulator 1; prefoldin subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:56612)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "16328889;18299400;20956523;21750661;21952136;22872234;25428506;25428507;25605945;30084848;30779550;31219806;31505240;34428180;35820727;36210013", "class_list": "", "function": "A genetic disruption in the murine Pfdn5 gene, a subunit of prefoldin, causes a syndrome characterized by photoreceptor degeneration, central nervous system abnormalities, and male infertility, [RefSeq, PubMed]; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity)., [UniProtKB]; Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus., [RefSeq, PubMed]; MM-1 may play a role in liver development and growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKS8;Q9JMJ8", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045111 intermediate filament cytoskeleton;GO:0016272 prefoldin complex", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0060041 retina development in camera-type eye;GO:0006457 protein folding;GO:1905907 negative regulation of amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WU28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q75N73-1", "uniprot_id": "S39AE_MOUSE", "mass": 53962.0, "length": 489, "protein_name": "Metal cation symporter ZIP14", "gene_name": "Slc39a14", "organism": "Mouse", "refseq_name": "metal cation symporter ZIP14 isoform a precursor", "refseq_ac": "NP_001128623", "gene_names_uniprotkb": "Slc39a14; Fad123; Kiaa0062; Zip14", "gene_names_refseq": "FAD-123; Slc39a14; ZIP-14; Zip14; fad123", "protein_names_uniprotkb": "Metal cation symporter ZIP14; FAD-123; Factor for adipocyte differentiation 123; Solute carrier family 39 member 14; ZIP-14; Zrt- and Irt-like protein 14", "protein_names_refseq": "Zrt- and Irt-like protein 14; factor for adipocyte differentiation 123; metal cation symporter ZIP14 isoform a precursor; metal cation symporter ZIP14; zinc transporter ZIP14", "tax_id": 10090, "disease": "hypermanganesemia with dystonia 2 (Disease Ontology:DOID:0080537)", "pathway": " (mmu:213053); (R-MMU-442380)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;15794747;15863613;16950869;17065364;18270315;19179618;19349973;19656770;20682781;21445361;21653899;21750661;23110240;25428506;25428902;26028554;27703010;28057442;28536273;28673968;29621230;29632817;30084848;30899004;31028174;37978473;38019082", "class_list": "", "function": "Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia., [RefSeq, PubMed]; Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15863613, PubMed:16950869, PubMed:18270315, PubMed:19179618, PubMed:21653899, PubMed:28673968). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (PubMed:18270315). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:18270315). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (PubMed:25428902). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (PubMed:21445361). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (PubMed:28673968). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (By similarity). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (PubMed:28536273). Also functions in the extracellular uptake of free iron (PubMed:16950869, PubMed:19179618, PubMed:21653899, PubMed:23110240, PubMed:26028554). May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression. Publication Status: Online-Only, [RefSeq, PubMed]; SLC39A14 plays a role as a zinc transporter during the early stages of adipogenesis, [RefSeq, PubMed]; The present study provides the complete characterization of Slc39a14 gene and its ZIP14 mRNAs and proteins and for the first time demonstrates the significance of ZIP14 in Cd2+-mediated cell damage. Erratum:[Mol Pharmacol. 2008 Sep;74(3):924], [RefSeq, PubMed]; Zip14 can mediate the uptake of zinc and non-transferrin-bound iron into cells., [RefSeq, PubMed]; Zip14 expression is up-regulated through IL-6, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J1V1;Q80U85;Q8VDL0", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0015086 cadmium ion transmembrane transporter activity;GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0034755 iron ion transmembrane transport;GO:0032869 cellular response to insulin stimulus;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q75N73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVF2-1", "uniprot_id": "PDCL3_MOUSE", "mass": 27581.0, "length": 240, "protein_name": "Phosducin-like protein 3", "gene_name": "Pdcl3", "organism": "Mouse", "refseq_name": "phosducin-like protein 3", "refseq_ac": "NP_081126", "gene_names_uniprotkb": "Pdcl3; Viaf1", "gene_names_refseq": "1110061A19Rik; Pdcl3; Viaf1", "protein_names_uniprotkb": "Phosducin-like protein 3; VIAF-1; Viral IAP-associated factor 1", "protein_names_refseq": "IAP-associated factor VIAF1; VIAF-1; phosducin-like protein 3; viral IAP-associated factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68833)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15371430;21183079;21750661;26059764;27496612;34428180;37507081", "class_list": "", "function": "Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins., [RefSeq, PubMed]; The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH06;Q99JX2;Q9D0W3", "ec_number_list": "", "go_molecular_function": "GO:0043184 vascular endothelial growth factor receptor 2 binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0010628 positive regulation of gene expression;GO:0006915 apoptotic process;GO:0034605 cellular response to heat;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BVF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XY4-1", "uniprot_id": "PCDG4_MOUSE", "mass": 100358.0, "length": 930, "protein_name": "Protocadherin gamma-A4", "gene_name": "Pcdhga4", "organism": "Mouse", "refseq_name": "protocadherin gamma-A4 precursor", "refseq_ac": "NP_291065", "gene_names_uniprotkb": "Pcdhga4", "gene_names_refseq": "Pcdhga4", "protein_names_uniprotkb": "Protocadherin gamma-A4; PCDH-gamma-A4", "protein_names_refseq": "PCDH-gamma-A4; protocadherin gamma-A4 precursor; protocadherin gamma-A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:93712)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11230163;15964765;19776259;21750661", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 6, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y31", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91XY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWB5-1", "uniprot_id": "PGPIL_MOUSE", "mass": 14267.0, "length": 130, "protein_name": "Pyroglutamyl-peptidase 1-like protein", "gene_name": "Pgpep1l", "organism": "Mouse", "refseq_name": "pyroglutamyl-peptidase 1-like protein", "refseq_ac": "NP_084377", "gene_names_uniprotkb": "Pgpep1l", "gene_names_refseq": "C330024D12Rik; Pgpep1l", "protein_names_uniprotkb": "Pyroglutamyl-peptidase 1-like protein; 3.4.19.-", "protein_names_refseq": "pyroglutamyl-peptidase 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78444)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008234 cysteine-type peptidase activity;GO:0016920 pyroglutamyl-peptidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQR7-1", "uniprot_id": "PEN2_MOUSE", "mass": 11999.0, "length": 101, "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "Psenen", "organism": "Mouse", "refseq_name": "gamma-secretase subunit PEN-2", "refseq_ac": "NP_079774", "gene_names_uniprotkb": "Psenen; Pen2", "gene_names_refseq": "1700023M09Rik; Pen-2; Pen2; Psenen", "protein_names_uniprotkb": "Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2", "protein_names_refseq": "gamma-secretase subunit PEN-2; presenilin enhancer 2 homolog; presenilin enhancer protein 2", "tax_id": 10090, "disease": "hidradenitis suppurativa (Disease Ontology:DOID:2280)", "pathway": " (mmu:66340); (R-MMU-1251985); (R-MMU-193692); (R-MMU-205043); (R-MMU-3928665); (R-MMU-9013507); (R-MMU-9017802); (R-MMU-9839383)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "12522139;21750661;24941111;34428180;35197629;35575074;38072061", "class_list": "", "function": "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:24941111). Besides its role in gamma-secretase complex, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds metformin, an antidiabetic drug, promoting association with ATP6AP1, a subunit of the V-ATPase complex, leading to V-ATPase complex inhibition on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis (PubMed:35197629)., [UniProtKB, PubMed, PubMed, PubMed]; Functional and topological analysis of PSENEN, the fourth subunit of the gamma-secretase complex., [RefSeq, PubMed]; Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0016485 protein processing;GO:0042982 amyloid precursor protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY39-1", "uniprot_id": "PDZD4_MOUSE", "mass": 86819.0, "length": 772, "protein_name": "PDZ domain-containing protein 4", "gene_name": "Pdzd4", "organism": "Mouse", "refseq_name": "PDZ domain-containing protein 4 isoform 1", "refseq_ac": "NP_001025039", "gene_names_uniprotkb": "Pdzd4; Pdzk4; Pdzrn4l; Xlu", "gene_names_refseq": "B230341P03; D130075J17Rik; Kiaa1444-hp; LU1; PDZRN4L; Pdzd4; Pdzk4; Pdzrnk4l; Xlu", "protein_names_uniprotkb": "PDZ domain-containing protein 4; PDZ domain-containing RING finger protein 4-like protein", "protein_names_refseq": "PDZ domain-containing RING finger protein 4-like protein; PDZ domain-containing protein 4 isoform 1; PDZ domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:245469)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFG4;Q6PHP2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005938 cell cortex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QY39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHD8-1", "uniprot_id": "PCMD2_MOUSE", "mass": 40756.0, "length": 359, "protein_name": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 2", "gene_name": "Pcmtd2", "organism": "Mouse", "refseq_name": "protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform b", "refseq_ac": "NP_001278140", "gene_names_uniprotkb": "Pcmtd2", "gene_names_refseq": "5330414D10Rik; Pcmtd2", "protein_names_uniprotkb": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 2", "protein_names_refseq": "protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform b; protein-L-isoaspartate O-methyltransferase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:245867)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKB7;Q8BJT6;Q8BK38;Q8C0H6;Q8R1D5", "ec_number_list": "", "go_molecular_function": "GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB60-1", "uniprot_id": "PXL2B_MOUSE", "mass": 21670.0, "length": 201, "protein_name": "Prostamide/prostaglandin F synthase", "gene_name": "Prxl2b", "organism": "Mouse", "refseq_name": "prostamide/prostaglandin F synthase", "refseq_ac": "NP_079858", "gene_names_uniprotkb": "Prxl2b; 2810405K02Rik; Fam213b", "gene_names_refseq": "2810405K02Rik; Fam213b; PM/PGFS; Prxl2b", "protein_names_uniprotkb": "Prostamide/prostaglandin F synthase; 1.11.1.20; Peroxiredoxin-like 2B; Prostamide/PG F synthase; Prostamide/PGF synthase", "protein_names_refseq": "family with sequence similarity 213, member B; prostamide/PG F synthase; prostamide/PGF synthase; prostamide/prostaglandin F synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66469)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18006499;20950588;21750661;33418484;39927985", "class_list": "", "function": "Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha)., [UniProtKB, PubMed]; Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.20", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0036130 prostaglandin H2 endoperoxidase reductase activity;GO:0047017 prostaglandin F synthase activity;GO:0008379 thioredoxin peroxidase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0019371 cyclooxygenase pathway;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DB60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXN7-1", "uniprot_id": "PBLD2_MOUSE", "mass": 31983.0, "length": 288, "protein_name": "Phenazine biosynthesis-like domain-containing protein 2", "gene_name": "Pbld2", "organism": "Mouse", "refseq_name": "phenazine biosynthesis-like domain-containing protein 2", "refseq_ac": "NP_080361", "gene_names_uniprotkb": "Pbld2; Mawbp1", "gene_names_refseq": "3110049J23Rik; Mawbp; Pbld2", "protein_names_uniprotkb": "Phenazine biosynthesis-like domain-containing protein 2", "protein_names_refseq": "MAWD binding protein homolog 2; phenazine biosynthesis-like domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67307)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;34059646;34428180;39362857;39779683", "class_list": "", "function": "Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication (PubMed:39362857, PubMed:39779683). Enhances IRF3-mediated innate immune signaling and promotes apoptotic cell death, thereby suppressing viral replication. Facilitates virus-induced type I interferon (IFN-I) signaling by promoting IRF3 phosphorylation. Upregulates the type I interferon (IFN-I) response by activating the NF-kappaB signaling pathway (PubMed:34059646). This may occur through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2W4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003824 catalytic activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002230 positive regulation of defense response to virus by host;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CXN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI19-1", "uniprot_id": "PDGFC_MOUSE", "mass": 38741.0, "length": 345, "protein_name": "Platelet-derived growth factor C", "gene_name": "Pdgfc", "organism": "Mouse", "refseq_name": "platelet-derived growth factor C isoform 1 precursor", "refseq_ac": "NP_064355", "gene_names_uniprotkb": "Pdgfc; Scdgf", "gene_names_refseq": "1110064L01Rik; PDGF-C; Pdgfc; SCDGF; VEGF-E", "protein_names_uniprotkb": "Platelet-derived growth factor C; Fallotein; PDGF-C; SCDGF; Spinal cord-derived growth factor; VEGF-E", "protein_names_refseq": "fallotein; platelet-derived growth factor C isoform 1 precursor; platelet-derived growth factor c; spinal cord-derived growth factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:54635); (R-MMU-186797)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10806482;10960785;11297552;11313995;11744381;12875986;12972405;15061151;15207812;15361870;15372073;15757957;15911618;16344272;16443219;16951379;17066417;18184860;21750661;35820727", "class_list": "", "function": "During development, PDGF-C expression was widespread and dynamic, and found in somites and their derivatives, in kidney, lung, brain, [RefSeq, PubMed]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q99JM4;Q9JHV8;Q9QY71", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0042803 protein homodimerization activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8CI19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CUX1-1", "uniprot_id": "P52K_MOUSE", "mass": 87021.0, "length": 758, "protein_name": "52 kDa repressor of the inhibitor of the protein kinase", "gene_name": "Thap12", "organism": "Mouse", "refseq_name": "52 kDa repressor of the inhibitor of the protein kinase isoform 1", "refseq_ac": "NP_082686", "gene_names_uniprotkb": "Thap12; Prkrir; Thap0", "gene_names_refseq": "2900052B10Rik; Dap4; Prkrir; Rpkrir; Thap12", "protein_names_uniprotkb": "52 kDa repressor of the inhibitor of the protein kinase; 58 kDa interferon-induced protein kinase-interacting protein; THAP domain-containing protein 0; THAP domain-containing protein 12; p52rIPK; p58IPK-interacting protein", "protein_names_refseq": "52 kDa repressor of the inhibitor of the protein kinase isoform 1; 52 kDa repressor of the inhibitor of the protein kinase; 58 kDa interferon-induced protein kinase-interacting protein; P52rIPK; THAP domain-containing protein 0; THAP domain-containing protein 12; interferon-inducible, double stranded RNA dependent inhibitor, protein-kinase; p58IPK-interacting protein; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)", "tax_id": 10090, "disease": "", "pathway": " (mmu:72981)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;25428506;30084848;30779550;31219806;34428180;36210013;39047044", "class_list": "", "function": "Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice., [RefSeq, PubMed]; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y58", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CUX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG81-1", "uniprot_id": "PDIP3_MOUSE", "mass": 46132.0, "length": 420, "protein_name": "Polymerase delta-interacting protein 3", "gene_name": "Poldip3", "organism": "Mouse", "refseq_name": "polymerase delta-interacting protein 3 isoform 2", "refseq_ac": "NP_001334011", "gene_names_uniprotkb": "Poldip3", "gene_names_refseq": "1110008P04Rik; PDIP46; Poldip3; SKAR; mKIAA1649", "protein_names_uniprotkb": "Polymerase delta-interacting protein 3; S6K1 Aly/REF-like target; SKAR", "protein_names_refseq": "S6K1 Aly/REF-like target; polymerase delta interacting protein 46; polymerase delta-interacting protein 3 isoform 2; polymerase delta-interacting protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73826); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "17242355;21183079;21750661;25605945;30084848;30779550;31219806;31599954;34428180", "class_list": "", "function": "Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2FDB4;Q6PE83;Q80X99;Q8CI28", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BG81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE62-1", "uniprot_id": "PAIP1_MOUSE", "mass": 45702.0, "length": 400, "protein_name": "Polyadenylate-binding protein-interacting protein 1", "gene_name": "Paip1", "organism": "Mouse", "refseq_name": "polyadenylate-binding protein-interacting protein 1 isoform 1", "refseq_ac": "NP_663432", "gene_names_uniprotkb": "Paip1", "gene_names_refseq": "PAIP-1; Paip1", "protein_names_uniprotkb": "Polyadenylate-binding protein-interacting protein 1; PABP-interacting protein 1; PAIP-1; Poly(A)-binding protein-interacting protein 1", "protein_names_refseq": "PABP-interacting protein 1; poly(A)-binding protein-interacting protein 1; polyadenylate-binding protein-interacting protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:218693); (R-MMU-429947)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848;30295753;30779550;32827170;38341068", "class_list": "", "function": "Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma., [RefSeq, PubMed]; PAIP1 regulates the translation of YBX2-masked mRNAs during spermiogenesis., [RefSeq, PubMed]; YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUC9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0106002 mCRD-mediated mRNA stability complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0006446 regulation of translational initiation;GO:0044794 host-mediated activation of viral process;GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VE62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TCG2-1", "uniprot_id": "PAQR9_MOUSE", "mass": 42741.0, "length": 375, "protein_name": "Membrane progesterone receptor epsilon", "gene_name": "Paqr9", "organism": "Mouse", "refseq_name": "membrane progesterone receptor epsilon", "refseq_ac": "NP_940806", "gene_names_uniprotkb": "Paqr9", "gene_names_refseq": "1700020G04Rik; Blnc1; C730029A08Rik; Paqr9", "protein_names_uniprotkb": "Membrane progesterone receptor epsilon; Membrane progesterone P4 receptor epsilon; Membrane progestin receptor epsilon; Progesterone and adipoQ receptor family member 9; Progestin and adipoQ receptor family member 9; Progestin and adipoQ receptor family member IX; mPR epsilon", "protein_names_refseq": "brown fat lncRNA 1; mPR epsilon; membrane progesterone P4 receptor epsilon; membrane progesterone receptor epsilon; membrane progestin receptor epsilon; progesterone and adipoQ receptor family member 9; progestin and adipoQ receptor family member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:75552)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16044242;25002143;29934059;30061575;30084848;34428180;37499998", "class_list": "", "function": "Blnc1 attenuates proinflammatory cytokine signaling and promotes fuel storage in adipocytes through its protein partner Zbtb7b., [RefSeq, PubMed]; Blnc1 forms a ribonucleoprotein complex with transcription factor EBF2 to stimulate the thermogenic gene program. Further, Blnc1 itself is a target of EBF2 forming a feedforward regulatory loop to drive adipogenesis toward thermogenic phenotype., [RefSeq, PubMed]; Hepatic expression of the lncRNA Blnc1 is strongly elevated in obesity and nonalcoholic fatty liver disease in mice Publication Status: Online-Only, [RefSeq, PubMed]; PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in beta cells in vitro under stress conditions., [RefSeq, PubMed]; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0N1", "ec_number_list": "", "go_molecular_function": "GO:0005496 steroid binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6TCG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFY6-1", "uniprot_id": "PEF1_MOUSE", "mass": 29228.0, "length": 275, "protein_name": "Peflin", "gene_name": "Pef1", "organism": "Mouse", "refseq_name": "peflin", "refseq_ac": "NP_080717", "gene_names_uniprotkb": "Pef1", "gene_names_refseq": "2600002E23Rik; Pef1; Peflin", "protein_names_uniprotkb": "Peflin; PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1", "protein_names_refseq": "PEF protein with a long N-terminal hydrophobic domain; peflin; penta-EF hand domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67898)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22645316;25153642;28135057;28528544;30084848;34428180;34762908", "class_list": "", "function": "ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling., [RefSeq, PubMed]; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCT5;Q9CYW8;Q9D934", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0051592 response to calcium ion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BFY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BU25-1", "uniprot_id": "PAMR1_MOUSE", "mass": 80320.0, "length": 720, "protein_name": "Inactive serine protease PAMR1", "gene_name": "Pamr1", "organism": "Mouse", "refseq_name": "inactive serine protease PAMR1 precursor", "refseq_ac": "NP_776110", "gene_names_uniprotkb": "Pamr1; Ramp", "gene_names_refseq": "5930437L24; E430002G05Rik; Pamr1; Ramp", "protein_names_uniprotkb": "Inactive serine protease PAMR1; Peptidase domain-containing protein associated with muscle regeneration 1; Regeneration-associated muscle protease homolog", "protein_names_refseq": "inactive serine protease PAMR1 precursor; inactive serine protease PAMR1; peptidase domain-containing protein associated with muscle regeneration 1; regeneration associated muscle protease; regeneration-associated muscle protease homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:210622)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15111323;22517741;26018251;30084848;30899004;32518939;32782141;35822049;40885482", "class_list": "", "function": "May play a role in regeneration of skeletal muscle., [UniProtKB]; RAMP may play a role in the regeneration of skeletal muscle, and its down-regulation could be involved in the progression of Duchenne muscular dystrophy, [RefSeq, PubMed]; Related to islet dysfunction during the development of type 2 diabetes, [RefSeq, PubMed]; The single EGF-like domain of mouse PAMR1 is modified by O-Glucose, O-Fucose and O-GlcNAc., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AQI2;Q8K2B8", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BU25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUY9-1", "uniprot_id": "PGTB1_MOUSE", "mass": 42354.0, "length": 377, "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "Pggt1b", "organism": "Mouse", "refseq_name": "geranylgeranyl transferase type-1 subunit beta isoform 1", "refseq_ac": "NP_766215", "gene_names_uniprotkb": "Pggt1b", "gene_names_refseq": "2010207C17Rik; 2610100E13; BGG1; GGT1; Pggt1b", "protein_names_uniprotkb": "Geranylgeranyl transferase type-1 subunit beta; 2.5.1.59; GGTase-I-beta; Geranylgeranyl transferase type I subunit beta; Type I protein geranyl-geranyltransferase subunit beta", "protein_names_refseq": "GGTase-I-beta; geranylgeranyl transferase type I subunit beta; geranylgeranyl transferase type-1 subunit beta isoform 1; geranylgeranyl transferase type-1 subunit beta; type I protein geranyl-geranyltransferase subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:225467); (R-MMU-9953170)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20106865;21750661;25428506", "class_list": "", "function": "Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes., [RefSeq, PubMed]; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.60;2.5.1.58;2.5.1.59;3.6.5.-", "go_molecular_function": "GO:0004661 protein geranylgeranyltransferase activity;GO:0004662 CAAX-protein geranylgeranyltransferase activity;GO:0008270 zinc ion binding;GO:1901363 heterocyclic compound binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005953 CAAX-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045787 positive regulation of cell cycle;GO:0018344 protein geranylgeranylation;GO:0080120 CAAX-box protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BUY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYI6-1", "uniprot_id": "PCAT2_MOUSE", "mass": 60254.0, "length": 544, "protein_name": "Lysophosphatidylcholine acyltransferase 2", "gene_name": "Lpcat2", "organism": "Mouse", "refseq_name": "lysophosphatidylcholine acyltransferase 2 isoform a", "refseq_ac": "NP_766602", "gene_names_uniprotkb": "Lpcat2; Aytl1a; Aytl1; Lpcat2a", "gene_names_refseq": "1-AGPAT 11; A330042H22; Aytl1a; Aytl1; Lpcat2; lpafat1; lysoPAFAT/LPCAT2; lysoPAFAT", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 2; 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; 2.3.1.25; 2.3.1.51; 2.3.1.67; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyltransferase-like 1; LPC acyltransferase 2; LPCAT-2; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPC acyltransferase 2", "protein_names_refseq": "1-AGP acyltransferase 11; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 2; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase member 1; acyltransferase like 1A; lyso-PAF acetyltransferase; lysoPC acyltransferase 2; lysophosphatidylcholine acyltransferase 2 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:270084); (R-MMU-1482788)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17182612;18156367;18285344;20663880;24742674;26495903;38377392;38605214;39075841", "class_list": "", "function": "Cloned the mouse acetyl-CoA:LYSO-PAF acetyltransferase and found that the enzyme catalyzed not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids., [RefSeq, PubMed]; Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:18156367, PubMed:18285344). Activity is calcium-dependent (PubMed:17182612). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:17182612, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612, PubMed:18285344). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (PubMed:17182612). Under resting conditions, acyltransferase activity is preferred (PubMed:17182612). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (PubMed:17182612). Involved in the regulation of lipid droplet number and size (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis., [RefSeq, PubMed]; Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor., [RefSeq, PubMed]; Specific inhibition of the PAF biosynthetic activity by phosphorylated LPCAT2 will provide a novel target for the regulation of inflammatory disorders., [RefSeq, PubMed]; The role of lysophosphatidylcholine acyltransferase 2 in osteoblastic differentiation of C2C12 cells., [RefSeq, PubMed]; We show a new signaling pathway for rapid biosynthesis of PAF that is mediated by phosphorylation of LPCAT2 at Ser-34., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KBM0;A9Q1G2;A9Q1G3", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.51;2.3.1.15;2.3.1.67;2.3.1.25;2.3.1.-;2.3.1.121;2.3.1.n6;2.3.1.n7;3.1.1.3", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0061024 membrane organization;GO:0036151 phosphatidylcholine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BYI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIW5-1", "uniprot_id": "PEO1_MOUSE", "mass": 76993.0, "length": 685, "protein_name": "Twinkle mtDNA helicase", "gene_name": "Twnk", "organism": "Mouse", "refseq_name": "twinkle mtDNA helicase isoform 2", "refseq_ac": "NP_001335188", "gene_names_uniprotkb": "Twnk; Peo1", "gene_names_refseq": "D19Ertd626e; PEO; Peo1; Twinl; Twnk", "protein_names_uniprotkb": "Twinkle mtDNA helicase; 5.6.2.3; Progressive external ophthalmoplegia 1 protein homolog; T7 gp4-like protein with intramitochondrial nucleoid localization; T7-like mitochondrial DNA helicase; Twinkle protein, mitochondrial", "protein_names_refseq": "T7 gp4-like protein with intramitochondrial nucleoid localization; progressive external ophthalmoplegia 1 protein homolog; putative T7-like mitochodrial DNA helicase twinky; twinkle mtDNA helicase isoform 2; twinkle protein, mitochondrial", "tax_id": 10090, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 7 (Disease Ontology:DOID:0080126); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3 (Disease Ontology:DOID:0111520); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:226153); (R-MMU-9837999); (R-MMU-9913635)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15509589;16301523;21750661;25428506;27342873;30084848;30779550", "class_list": "", "function": "Essential for mtDNA maintenance, may be a key regulator of mtDNA copy number., [RefSeq, PubMed]; Generated transgenic mice expressing mouse Twinkle with progressive external ophthalmoplegia patient mutations, [RefSeq, PubMed]; Mitochondrial helicase involved in mtDNA replication and repair (By similarity). Might have a role in mtDNA repair (By similarity). Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB (By similarity). Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate (By similarity). Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand (By similarity). In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities (By similarity)., [UniProtKB, UniProtKB]; Twinkle overexpression alleviated impaired mitochondrial biogenesis in the border area through maintained mtDNA copy number and thereby prevented cardiac rupture accompanied by the reduction of apoptosis and oxidative stress, and suppression of MMP activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1Z1", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.5.3.1;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.-.-;5.3.3.21;7.6.2.1;3.6.1.5;3.1.2.-;3.1.2.2;3.4.24.-;3.6.-.-;1.1.1.37;3.1.3.1;3.9.1.1;3.6.1.-;4.98.1.1;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;1.4.1.3;5.3.3.8;3.6.4.6;1.2.1.3;2.3.1.168;2.7.7.7;3.1.11.-;4.2.99.-;2.3.3.10;7.1.2.2;3.6.5.-;5.6.1.7;3.6.1.15;3.1.4.-;4.2.1.2;5.6.2.-;7.2.2.-;7.6.2.16;1.2.4.2;2.7.11.2;6.1.1.5;2.7.7.6;2.7.1.23;3.4.21.53;2.7.7.49;2.7.11.1;2.3.1.9;2.7.4.3;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;1.2.4.1;2.8.3.5;2.3.1.41;1.3.8.5;1.3.8.1", "go_molecular_function": "GO:0002020 protease binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0000262 mitochondrial chromosome", "go_biological_process": "GO:0006260 DNA replication;GO:0006264 mitochondrial DNA replication;GO:0006261 DNA-templated DNA replication;GO:0034214 protein hexamerization;GO:0006390 mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CIW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K183-1", "uniprot_id": "PDXK_MOUSE", "mass": 35015.0, "length": 312, "protein_name": "Pyridoxal kinase", "gene_name": "Pdxk", "organism": "Mouse", "refseq_name": "pyridoxal kinase", "refseq_ac": "NP_742146", "gene_names_uniprotkb": "Pdxk; Pkh", "gene_names_refseq": "2310036D04Rik; Pdxk", "protein_names_uniprotkb": "Pyridoxal kinase; 2.7.1.35; Pyridoxine kinase", "protein_names_refseq": "pyridoxal kinase; pyridoxine kinase", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:216134); (R-MMU-6798695); (R-MMU-964975)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21183079;28135057;37507081", "class_list": "", "function": "Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM83;Q8BJQ5", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.19.12;3.2.1.18;3.4.24.34;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;3.4.21.-;3.2.1.17;3.6.5.-;4.2.1.24;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;1.11.1.6;1.1.1.205;3.1.3.48;5.3.2.1;5.3.3.12;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.6.5.2;3.4.21.37;3.5.3.1;3.1.1.47;3.6.4.13;3.2.1.166;2.3.2.26;5.4.2.2;5.4.2.7;1.8.3.2;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;4.1.2.4;2.3.2.5;3.1.21.-;3.2.1.14;5.4.2.11;5.4.2.4;2.4.1.1;3.5.1.3;2.4.1.186;3.4.18.1;3.4.19.9", "go_molecular_function": "GO:0031403 lithium ion binding;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042816 vitamin B6 metabolic process;GO:0009443 pyridoxal 5'-phosphate salvage", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R189-1", "uniprot_id": "PAQRA_MOUSE", "mass": 28910.0, "length": 247, "protein_name": "Monocyte to macrophage differentiation factor 2", "gene_name": "Mmd2", "organism": "Mouse", "refseq_name": "monocyte to macrophage differentiation factor 2 isoform 1", "refseq_ac": "NP_780426", "gene_names_uniprotkb": "Mmd2; Paqr10", "gene_names_refseq": "4930518M15Rik; Mmd2", "protein_names_uniprotkb": "Monocyte to macrophage differentiation factor 2; Progestin and adipoQ receptor family member 10; Progestin and adipoQ receptor family member X", "protein_names_refseq": "monocyte to macrophage differentiation factor 2 isoform 1; monocyte to macrophage differentiation factor 2; progestin and adipoQ receptor family member 10; progestin and adipoQ receptor family member X", "tax_id": 10090, "disease": "", "pathway": " (mmu:75104)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12617826;16044242;18769639;35306493", "class_list": "", "function": "Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice., [RefSeq, PubMed]; Identification of progestin & adipoQ receptor, PAQR10, in a screen for genes differentially expressed in pancreatic beta-cells; propose PAQR10 may act at level of the mitochondrion to regulate pancreatic endocrine cell development/survival, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0045666 positive regulation of neuron differentiation;GO:0045860 positive regulation of protein kinase activity;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R189-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4K8-1", "uniprot_id": "PAPP1_MOUSE", "mass": 181318.0, "length": 1624, "protein_name": "Pappalysin-1", "gene_name": "Pappa", "organism": "Mouse", "refseq_name": "pappalysin-1 precursor", "refseq_ac": "NP_067337", "gene_names_uniprotkb": "Pappa", "gene_names_refseq": "8430414N03Rik; IGFBP-4ase; PAG1; PAPP-A; Pappa", "protein_names_uniprotkb": "Pappalysin-1; 3.4.24.79; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPP-A; Pregnancy-associated plasma protein A", "protein_names_refseq": "IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; pappalysin-1 precursor; pappalysin-1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); myocardial infarction (Disease Ontology:DOID:5844); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18491); (R-MMU-381426)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11956166;11985604;12213189;31219806;34428180;36542300", "class_list": "", "function": "Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected., [UniProtKB, PubMed]; Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q80VW3;Q80YY1;Q8K423;Q8R4K7;Q9ES06;Q9JK57", "ec_number_list": "3.4.24.79", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007166 cell surface receptor signaling pathway;GO:0030163 protein catabolic process;GO:0071548 response to dexamethasone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R4K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCS0-1", "uniprot_id": "PGRP2_MOUSE", "mass": 57707.0, "length": 530, "protein_name": "N-acetylmuramoyl-L-alanine amidase", "gene_name": "Pglyrp2", "organism": "Mouse", "refseq_name": "N-acetylmuramoyl-L-alanine amidase isoform a precursor", "refseq_ac": "NP_001258405", "gene_names_uniprotkb": "Pglyrp2; Pglyrpl; Pgrpl", "gene_names_refseq": "C730002N09Rik; PGRP-L; Pglyrp2; Pglyrpl; tagL", "protein_names_uniprotkb": "N-acetylmuramoyl-L-alanine amidase; 3.5.1.28; PGRP-L; Peptidoglycan recognition protein 2; Peptidoglycan recognition protein long; TagL", "protein_names_refseq": "N-acetylmuramoyl-L-alanine amidase isoform a precursor; N-acetylmuramoyl-L-alanine amidase; peptidoglycan recognition protein long", "tax_id": 10090, "disease": "", "pathway": " (mmu:57757); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12559914;12821140;15340057;16944957;21750661;26332373;26495903;28951252;34428180;38277990", "class_list": "", "function": "In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi., [RefSeq, PubMed]; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity., [UniProtKB]; Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFkappaB inflammatory axis in coronary artery disease., [RefSeq, PubMed]; Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice Publication Status: Online-Only, [RefSeq, PubMed]; Study shows sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel role for Pglyrp2 as a key regulator of motor and anxiety-like behavior in late life., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4I8;Q9QXZ1;Q9QXZ2", "ec_number_list": "3.5.1.28", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0032827 negative regulation of natural killer cell differentiation involved in immune response;GO:0006955 immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0016045 detection of bacterium;GO:0032689 negative regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8VCS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W45-1", "uniprot_id": "PAI2B_MOUSE", "mass": 15472.0, "length": 136, "protein_name": "Polyadenylate-binding protein-interacting protein 2B", "gene_name": "Paip2b", "organism": "Mouse", "refseq_name": "polyadenylate-binding protein-interacting protein 2B", "refseq_ac": "NP_666281", "gene_names_uniprotkb": "Paip2b; Kiaa1155", "gene_names_refseq": "Paip2b", "protein_names_uniprotkb": "Polyadenylate-binding protein-interacting protein 2B; PABP-interacting protein 2B; PAIP-2B; Poly(A)-binding protein-interacting protein 2B", "protein_names_refseq": "PABP-interacting protein 2B; PAIP-2B; polyadenylate-binding protein-interacting protein 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:232164)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16804161;25428506;30084848", "class_list": "", "function": "Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJI7;Q69ZQ4;Q8BL93", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0030371 translation repressor activity;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91W45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XC9-1", "uniprot_id": "PEX16_MOUSE", "mass": 38677.0, "length": 336, "protein_name": "Peroxisomal membrane protein PEX16", "gene_name": "Pex16", "organism": "Mouse", "refseq_name": "peroxisomal biogenesis factor 16 isoform 1", "refseq_ac": "NP_660104", "gene_names_uniprotkb": "Pex16", "gene_names_refseq": "Pex16", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX16; Peroxin-16; Peroxisomal biogenesis factor 16", "protein_names_refseq": "peroxin-16; peroxisomal biogenesis factor 16 isoform 1; peroxisomal membrane protein PEX16", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 8A (Disease Ontology:DOID:0080483); Peroxisome biogenesis disorder 8B (Disease Ontology:DOID:0081437)", "pathway": " (mmu:18633); (R-MMU-9603798)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "34428180;35820727;40021952", "class_list": "", "function": "Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPY2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007031 peroxisome organization;GO:0006625 protein targeting to peroxisome;GO:0016558 protein import into peroxisome matrix;GO:0016557 peroxisome membrane biogenesis;GO:0022615 protein to membrane docking", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91XC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Y02-1", "uniprot_id": "PCDBI_MOUSE", "mass": 86959.0, "length": 792, "protein_name": "Protocadherin beta-18", "gene_name": "Pcdhb18", "organism": "Mouse", "refseq_name": "protocadherin beta-18 precursor", "refseq_ac": "NP_444373", "gene_names_uniprotkb": "Pcdhb18", "gene_names_refseq": "Pcdhb18; Pcdhb9; PcdhbR", "protein_names_uniprotkb": "Protocadherin beta-18; PCDH-beta-18", "protein_names_refseq": "PCDH-beta-18; protocadherin beta-18 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:93889)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11230163", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91Y02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Y11-1", "uniprot_id": "PCDA9_MOUSE", "mass": 106763.0, "length": 979, "protein_name": "Protocadherin alpha-9", "gene_name": "Pcdha9", "organism": "Mouse", "refseq_name": "protocadherin alpha-9 precursor", "refseq_ac": "NP_619602", "gene_names_uniprotkb": "Pcdha9", "gene_names_refseq": "Pcdha9", "protein_names_uniprotkb": "Protocadherin alpha-9; PCDH-alpha-9", "protein_names_refseq": "PCDH-alpha-9; protocadherin alpha-9 precursor", "tax_id": 10090, "disease": "sporadic amyotrophic lateral sclerosis (Disease Ontology:DOID:0080917)", "pathway": " (mmu:192161)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;11230163;38467605", "class_list": "", "function": "PCDHA9 as a candidate gene for amyotrophic lateral sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0003170 heart valve development;GO:0001701 in utero embryonic development;GO:0007155 cell adhesion;GO:0007507 heart development;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91Y11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Y20-1", "uniprot_id": "PCDAA_MOUSE", "mass": 102057.0, "length": 946, "protein_name": "Protocadherin alpha-10", "gene_name": "Pcdha10", "organism": "Mouse", "refseq_name": "protocadherin alpha-10 precursor", "refseq_ac": "NP_034091", "gene_names_uniprotkb": "Pcdha10", "gene_names_refseq": "Cnr3; Cnr8; Crnr3; Crnr8; Pcdha10; Pcdha14", "protein_names_uniprotkb": "Protocadherin alpha-10; PCDH-alpha-10", "protein_names_refseq": "PCDH-alpha-10; cadherin-related neuronal receptor 3; protocadherin alpha 14; protocadherin alpha-10 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:12943)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;11230163;35820727", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91Y20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZQ1-1", "uniprot_id": "PDE6C_MOUSE", "mass": 98785.0, "length": 861, "protein_name": "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'", "gene_name": "Pde6c", "organism": "Mouse", "refseq_name": "cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform 2", "refseq_ac": "NP_001164430", "gene_names_uniprotkb": "Pde6c", "gene_names_refseq": "Pde6c; cpfl1", "protein_names_uniprotkb": "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; 3.1.4.35; cGMP phosphodiesterase 6C", "protein_names_refseq": "cGMP phosphodiesterase 6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform 2; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'", "tax_id": 10090, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); achromatopsia (Disease Ontology:DOID:13911); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:110855)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;35644251;38110033", "class_list": "", "function": "An enhancer located in a Pde6c intron drives transient expression in the cone photoreceptors of developing mouse and human retinas., [RefSeq, PubMed]; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP., [UniProtKB, UniProtKB]; Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0D4", "ec_number_list": "3.1.4.-;3.1.4.35;3.1.4.53;3.1.4.17;3.6.1.25;3.6.1.14", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007601 visual perception;GO:0007603 phototransduction, visible light;GO:0050953 sensory perception of light stimulus;GO:0046549 retinal cone cell development;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922Q4-1", "uniprot_id": "P5CR2_MOUSE", "mass": 33659.0, "length": 320, "protein_name": "Pyrroline-5-carboxylate reductase 2", "gene_name": "Pycr2", "organism": "Mouse", "refseq_name": "pyrroline-5-carboxylate reductase 2", "refseq_ac": "NP_598466", "gene_names_uniprotkb": "Pycr2", "gene_names_refseq": "1810018M05Rik; P5cr2; Pycr2", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase 2; 1.5.1.2; P5C reductase 2; P5CR 2", "protein_names_refseq": "P5C reductase 2; P5CR 2; pyrroline-5-carboxylate reductase 2", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 10 (Disease Ontology:DOID:0060788); autosomal recessive cutis laxa type IIB (Disease Ontology:DOID:0070137)", "pathway": " (mmu:69051); (R-MMU-8964539)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;25605945;32330411;33734376", "class_list": "", "function": "Genetic analysis of Pycr1 and Pycr2 in mice., [RefSeq, PubMed]; Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2., [RefSeq, PubMed]; Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q922Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQY7-1", "uniprot_id": "PAQRB_MOUSE", "mass": 27677.0, "length": 238, "protein_name": "Monocyte to macrophage differentiation factor", "gene_name": "Mmd", "organism": "Mouse", "refseq_name": "monocyte to macrophage differentiation factor isoform 1", "refseq_ac": "NP_080454", "gene_names_uniprotkb": "Mmd; Paqr11", "gene_names_refseq": "1200017E07Rik; 1810073C06Rik; Mmd; Paqr11", "protein_names_uniprotkb": "Monocyte to macrophage differentiation factor; Progestin and adipoQ receptor family member 11; Progestin and adipoQ receptor family member XI", "protein_names_refseq": "monocyte to macrophage differentiation factor isoform 1; monocyte to macrophage differentiation factor; monocyte to macrophage differentiation protein; progestin and adipoQ receptor family member 11; progestin and adipoQ receptor family member XI", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:67468)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16044242;21750661;22203480;33421113;33549845", "class_list": "", "function": "Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D., [RefSeq, PubMed]; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion., [UniProtKB]; PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis., [RefSeq, PubMed]; These results suggested that MMD modulates TNF-alpha and NO production in macrophages, and this process might involves Erk or Akt., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAU1;Q5SVU7", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0045860 positive regulation of protein kinase activity;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZG9-1", "uniprot_id": "PDZ11_MOUSE", "mass": 16182.0, "length": 140, "protein_name": "PDZ domain-containing protein 11", "gene_name": "Pdzd11", "organism": "Mouse", "refseq_name": "PDZ domain-containing protein 11", "refseq_ac": "NP_082579", "gene_names_uniprotkb": "Pdzd11; Pdzk11", "gene_names_refseq": "1810012H22Rik; 2310079D11Rik; 2700099C19Rik; Pdzd11; Pdzk11", "protein_names_uniprotkb": "PDZ domain-containing protein 11", "protein_names_refseq": "PDZ domain-containing protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:72621); (R-MMU-196780); (R-MMU-199220); (R-MMU-425397); (R-MMU-6803544); (R-MMU-936837)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "30463011", "class_list": "", "function": "Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0030674 protein-macromolecule adaptor activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006768 biotin metabolic process;GO:0046931 pore complex assembly;GO:0007269 neurotransmitter secretion;GO:0048489 synaptic vesicle transport;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5U0-1", "uniprot_id": "PCT2B_MOUSE", "mass": 58381.0, "length": 516, "protein_name": "Lysophosphatidylcholine acyltransferase 2B", "gene_name": "Lpcat2b", "organism": "Mouse", "refseq_name": "lysophosphatidylcholine acyltransferase 2B", "refseq_ac": "NP_081875", "gene_names_uniprotkb": "Lpcat2b; Aytl1b", "gene_names_refseq": "4921521K07Rik; Aytl1b; Lpcat2b", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 2B; 2.3.1.-; Acyltransferase-like 1-B", "protein_names_refseq": "acyltransferase like 1B; acyltransferase-like 1-B; lysophosphatidylcholine acyltransferase 2-B; lysophosphatidylcholine acyltransferase 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:70902)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Probable acetyltransferase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0046486 glycerolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D5U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6V8-1", "uniprot_id": "PAIP2_MOUSE", "mass": 14700.0, "length": 124, "protein_name": "Polyadenylate-binding protein-interacting protein 2", "gene_name": "Paip2", "organism": "Mouse", "refseq_name": "polyadenylate-binding protein-interacting protein 2", "refseq_ac": "NP_080696", "gene_names_uniprotkb": "Paip2", "gene_names_refseq": "2310050K10Rik; Paip2", "protein_names_uniprotkb": "Polyadenylate-binding protein-interacting protein 2; PABP-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2", "protein_names_refseq": "PAIP-2; Pabp-interacting protein 2; poly(A)-binding protein-interacting protein 2; polyadenylate-binding protein-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67869)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15175342;16804161;23622065;34428180;35820727", "class_list": "", "function": "Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity)., [UniProtKB]; PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis, [RefSeq, PubMed]; This study demonstrated that activity-dependent degradation of PAIP2A relieves translational inhibition of memory-related genes through PABP reactivation and conclude that PAIP2A is a pivotal translational regulator of synaptic plasticity and memory., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBH5;Q9DAW7", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003729 mRNA binding;GO:0030371 translation repressor activity;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0007613 memory;GO:0017148 negative regulation of translation;GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D6V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPR2-1", "uniprot_id": "PG12A_MOUSE", "mass": 21319.0, "length": 192, "protein_name": "Group XIIA secretory phospholipase A2", "gene_name": "Pla2g12a", "organism": "Mouse", "refseq_name": "group XIIA secretory phospholipase A2 isoform 1 precursor", "refseq_ac": "NP_075685", "gene_names_uniprotkb": "Pla2g12a; Pla2g12", "gene_names_refseq": "2310004B05Rik; GXII-1-PLA2; GXII-1; GXII; Pla2g12a; Pla2g12; Rossy; mGXII-1", "protein_names_uniprotkb": "Group XIIA secretory phospholipase A2; 3.1.1.4; GXII sPLA2; Phosphatidylcholine 2-acylhydrolase 12A; sPLA2-XII", "protein_names_refseq": "group XII-1 phospholipase A2; group XIIA secreted phospholipase A2; group XIIA secretory phospholipase A2 isoform 1 precursor; group XIIA secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66350); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "11278438;21750661", "class_list": "", "function": "PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQC4;Q9CQR3;Q9CTL1;Q9D7L3;Q9EPR1", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.51", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EPR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJP2-1", "uniprot_id": "P73_MOUSE", "mass": 69096.0, "length": 631, "protein_name": "Tumor protein p73", "gene_name": "Tp73; Trp73", "organism": "Mouse", "refseq_name": "tumor protein p73 isoform b", "refseq_ac": "NP_001119802", "gene_names_uniprotkb": "Tp73; Trp73; P73; Trp73", "gene_names_refseq": "TAp73; Tp73; Trp73; deltaNp73; p73", "protein_names_uniprotkb": "Tumor protein p73; p53-like transcription factor; p53-related protein", "protein_names_refseq": "tumor protein p73 isoform b", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); otitis media (Disease Ontology:DOID:10754); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); testicular cancer (Disease Ontology:DOID:2998); breast ductal carcinoma (Disease Ontology:DOID:3007); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:22062); (R-MMU-6804759); (R-MMU-8939236)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10232589;10716451;11932750;15113856;16461361;21750661;26947080;30084848", "class_list": "", "function": "Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression., [UniProtKB, UniProtKB, UniProtKB]; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression, essential for the positive regulation of lung ciliated cell differentiation (PubMed:26947080)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AX89;B1AX90;Q3UT91;Q9CU77;Q9JJP1;Q9WUJ0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:1901248 positive regulation of lung ciliated cell differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051262 protein tetramerization;GO:2001235 positive regulation of apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK84-1", "uniprot_id": "PAR6G_MOUSE", "mass": 42341.0, "length": 382, "protein_name": "Partitioning defective 6 homolog gamma", "gene_name": "Pard6g", "organism": "Mouse", "refseq_name": "partitioning defective 6 homolog gamma", "refseq_ac": "NP_444347", "gene_names_uniprotkb": "Pard6g; Par6g", "gene_names_refseq": "2410049N21Rik; Par6a; Pard6g", "protein_names_uniprotkb": "Partitioning defective 6 homolog gamma; PAR-6 gamma; PAR6A", "protein_names_refseq": "PAR-6 gamma; par-6 partitioning defective 6 homolog gamma; partitioning defective 6 homolog gamma; partitioning-defective protein 6, alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:93737); (R-MMU-420029)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10934474;26876178;32848054;34428180;34678516", "class_list": "", "function": "Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity)., [UniProtKB]; Prkci and its downstream partners, such a Pard6g, direct polarized cell division of luminal myocardial cells to drive trabeculation in the nascent heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005923 bicellular tight junction;GO:0005938 cell cortex;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JK84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QW08-1", "uniprot_id": "PHOS_MOUSE", "mass": 28016.0, "length": 244, "protein_name": "Phosducin", "gene_name": "Pdc", "organism": "Mouse", "refseq_name": "phosducin", "refseq_ac": "NP_001153202", "gene_names_uniprotkb": "Pdc; Rpr1", "gene_names_refseq": "Pdc; Rpr-1; Rpr1", "protein_names_uniprotkb": "Phosducin; 33 kDa phototransducing protein; PHD; RPR-1; Rod photoreceptor 1", "protein_names_refseq": "33 kDa phototransducing protein; PHD; phosducin; rod photoreceptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20028)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22491418;34203471;8224906;8405193", "class_list": "", "function": "Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QW08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1B3-1", "uniprot_id": "PIANP_MOUSE", "mass": 29744.0, "length": 278, "protein_name": "PILR alpha-associated neural protein", "gene_name": "Pianp", "organism": "Mouse", "refseq_name": "PILR alpha-associated neural protein precursor", "refseq_ac": "NP_001139398", "gene_names_uniprotkb": "Pianp; C530028O21Rik; Panp", "gene_names_refseq": "C530028O21Rik; Panp; Pianp", "protein_names_uniprotkb": "PILR alpha-associated neural protein; Brain protein 1; PILR-associating neural protein; Paired immunoglobin-like type 2 receptor-associating neural protein", "protein_names_refseq": "PILR alpha-associated neural protein precursor; PILR-associating neural protein; brain protein 1; paired immunoglobin-like type 2 receptor-associating neural protein", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:319352); (R-MMU-198933)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21241660;21750661;23558288;26188512;27349870;31511635;35820727", "class_list": "", "function": "Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation., [UniProtKB, PubMed]; Demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation, [RefSeq, PubMed]; Furin-like proprotein convertase-dependent processing precedes the plasma membrane localization of LEDA-1/PIANP that is required for functional receptor-ligand interactions in vitro and in vivo., [RefSeq, PubMed]; Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior., [RefSeq, PubMed]; These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha., [RefSeq, PubMed]; Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFR0;Q71A40;Q8BHU8", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0008542 visual learning;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0050776 regulation of immune response;GO:0035176 social behavior;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6P1B3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB26-1", "uniprot_id": "PHYD1_MOUSE", "mass": 32517.0, "length": 291, "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "gene_name": "Phyhd1", "organism": "Mouse", "refseq_name": "phytanoyl-CoA dioxygenase domain-containing protein 1 isoform 2", "refseq_ac": "NP_001239497", "gene_names_uniprotkb": "Phyhd1", "gene_names_refseq": "Phyhd1", "protein_names_uniprotkb": "Phytanoyl-CoA dioxygenase domain-containing protein 1; 1.14.11.-; Protein PHYHD1", "protein_names_refseq": "phytanoyl-CoA dioxygenase domain-containing protein 1 isoform 2; phytanoyl-CoA dioxygenase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227696)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;26970303", "class_list": "", "function": "2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our findings suggest that Phyhd1 and Phyh have distinct roles in mouse leukocytes and Phyhd1 is related to T cell differentiation and/or function of effector T cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQZ4;Q80V68", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DB26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VC7-1", "uniprot_id": "PP14A_MOUSE", "mass": 16649.0, "length": 147, "protein_name": "Protein phosphatase 1 regulatory subunit 14A", "gene_name": "Ppp1r14a", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 14A isoform 1", "refseq_ac": "NP_081007", "gene_names_uniprotkb": "Ppp1r14a; Cpi17", "gene_names_refseq": "1110001M11Rik; CPI-17; Cpi17; Ppp1r14a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; CPI-17; Protein kinase C-potentiated inhibitor protein of 17 kDa", "protein_names_refseq": "17 kDa PKC-potentiated inhibitory protein of PP1; protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory subunit 14A isoform 1; protein phosphatase 1 regulatory subunit 14A", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:68458); (R-MMU-5625740)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11931393;12974676;15123611;21183079;21750661;25724497;26215803;29229685;29528115;30936247;30948334", "class_list": "", "function": "CPI-17 phosphorylation at T38 is essential for the maintenance of physiological blood pressure., [RefSeq, PubMed]; Concluded that actions downstream of cGMP/PKG can reverse PKC-mediated phosphorylation of CPI-17 and Ca(2+) sensitization in smooth muscle, [RefSeq, PubMed]; Distribution of mouse and rat PPP1R14A was more specific and different from that of humans, [RefSeq, PubMed]; Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1alpha but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy., [RefSeq, PubMed]; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These data provide a novel mechanism of the transcriptional control of CPI-17 in vascular smooth muscle cells under inflammatory conditions. Mechanistically, 2 GC boxes were identified as TNF response element in the CPI-17 promoter and KLF4 was upregulated by TNF, competed with Sp1 for the binding to the GC boxes in the CPI-17 promoter, and repressed CPI-17 transcription through histone deacetylase. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of CPI-17-mediated calcium-sensitized vasocontraction by obesity contributes to the development of obesity-related hypertension, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MB9", "ec_number_list": "", "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91VC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28654-1", "uniprot_id": "PGS2_MOUSE", "mass": 39809.0, "length": 354, "protein_name": "Decorin", "gene_name": "Dcn", "organism": "Mouse", "refseq_name": "decorin preproprotein", "refseq_ac": "NP_001177380", "gene_names_uniprotkb": "Dcn", "gene_names_refseq": "DC; DSPG2; Dcn; PG40; PGII; PGS2; SLRR1B", "protein_names_uniprotkb": "Decorin; Bone proteoglycan II; PG-S2; PG40", "protein_names_refseq": "bone proteoglycan II; decorin preproprotein", "tax_id": 10090, "disease": "congenital stromal corneal dystrophy (Disease Ontology:DOID:0060445); gestational diabetes (Disease Ontology:DOID:11714); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13179); (R-MMU-1474228); (R-MMU-1971475); (R-MMU-2022870); (R-MMU-2022923); (R-MMU-2024101); (R-MMU-3000178)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;34428180;35820727;37507081;39927985;7961765", "class_list": "glycogene", "function": "May affect the rate of fibrils formation., [UniProtKB]; This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding;GO:0050840 extracellular matrix binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber;GO:0005589 collagen type VI trimer", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010508 positive regulation of autophagy;GO:0016525 negative regulation of angiogenesis;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P28654-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16331-1", "uniprot_id": "PH4H_MOUSE", "mass": 51900.0, "length": 453, "protein_name": "Phenylalanine-4-hydroxylase", "gene_name": "Pah", "organism": "Mouse", "refseq_name": "phenylalanine-4-hydroxylase", "refseq_ac": "NP_032803", "gene_names_uniprotkb": "Pah", "gene_names_refseq": "Pah", "protein_names_uniprotkb": "Phenylalanine-4-hydroxylase; 1.14.16.1; PAH; Phe-4-monooxygenase", "protein_names_refseq": "phe-4-monooxygenase; phenylalanine-4-hydroxylase", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (mmu:18478); (R-MMU-8964208)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;2334400;34428180;37453647;6098294;7387651;9119379", "class_list": "", "function": "Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WV1", "ec_number_list": "1.14.16.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004505 phenylalanine 4-monooxygenase activity", "go_cellular_component": "", "go_biological_process": "GO:0006571 tyrosine biosynthetic process;GO:0006559 L-phenylalanine catabolic process;GO:0006558 L-phenylalanine metabolic process;GO:0018126 protein hydroxylation;GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P16331-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D240-1", "uniprot_id": "PKHJ1_MOUSE", "mass": 19029.0, "length": 164, "protein_name": "Pleckstrin homology domain-containing family J member 1", "gene_name": "Plekhj1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family J member 1", "refseq_ac": "NP_076389", "gene_names_uniprotkb": "Plekhj1; Gnrpx", "gene_names_refseq": "9530063M10Rik; Plekhj1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family J member 1; Guanine nucleotide-releasing protein x; PH domain-containing family J member 1", "protein_names_refseq": "PH domain-containing family J member 1; guanine nucleotide releasing protein x; pleckstrin homology domain-containing family J member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78670)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11602354;21750661;22872234;31219806;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ13;Q9EPF0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A559-1", "uniprot_id": "PGAP3_MOUSE", "mass": 36528.0, "length": 320, "protein_name": "GPI-specific phospholipase A2-like PGAP3", "gene_name": "Pgap3", "organism": "Mouse", "refseq_name": "GPI-specific phospholipase A2-like PGAP3 precursor", "refseq_ac": "NP_001028709", "gene_names_uniprotkb": "Pgap3; Perld1", "gene_names_refseq": "CAB2; D430035D22Rik; Perld1; Pgap3", "protein_names_uniprotkb": "GPI-specific phospholipase A2-like PGAP3; 3.1.1.-; PER1-like domain-containing protein 1; Post-GPI attachment to proteins factor 3", "protein_names_refseq": "GPI-specific phospholipase A2-like PGAP3 precursor; GPI-specific phospholipase A2-like PGAP3; PER1-like domain-containing protein 1; per1-like domain containing 1; post-GPI attachment to proteins factor 3", "tax_id": 10090, "disease": "hyperphosphatasia with impaired intellectual development syndrome (Disease Ontology:DOID:0070431); hyperphosphatasia with impaired intellectual development syndrome 4 (Disease Ontology:DOID:0070436); chronic asthma (Disease Ontology:DOID:0080809); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:320655)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;22227195", "class_list": "", "function": "Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts., [UniProtKB, UniProtKB]; The response of T cells was enhanced in Pgap3 knockout mice in both in vitro and in vivo studies, including alloreactive response, antigen-specific immune response, and experimental autoimmune encephalomyelitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A558;Q3TCA8", "ec_number_list": "3.1.1.-", "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006505 GPI anchor metabolic process;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2A559-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70669-1", "uniprot_id": "PHEX_MOUSE", "mass": 86419.0, "length": 749, "protein_name": "Phosphate-regulating neutral endopeptidase PHEX", "gene_name": "Phex", "organism": "Mouse", "refseq_name": "phosphate-regulating neutral endopeptidase PHEX", "refseq_ac": "NP_035207", "gene_names_uniprotkb": "Phex; Hyp; Pex", "gene_names_refseq": "Gy; HPDR1; HPDR; Hyp; PEX; Phex", "protein_names_uniprotkb": "Phosphate-regulating neutral endopeptidase PHEX; 3.4.24.-; HYP; Metalloendopeptidase homolog PEX; Phosphate regulating neutral endopeptidase; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein", "protein_names_refseq": "Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein); X-linked hypophosphatemia protein; X-linked phosphate regulating endopeptidase; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); phosphate regulating neutral endopeptidase; phosphate-regulating neutral endopeptidase PHEX; vitamin D-resistant hypophosphatemic rickets protein", "tax_id": 10090, "disease": "X-linked hypophosphatemic rickets (Disease Ontology:DOID:0050445); heart conduction disease (Disease Ontology:DOID:10273); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754)", "pathway": " (mmu:18675)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11159866;11811562;18597632;21750661;25428506;26051469;30084848;38442738;8812412;9063736;9077527", "class_list": "", "function": "Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation., [RefSeq, PubMed]; Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (By similarity). Cleaves ASARM peptides between Ser and Glu or Asp residues (By similarity). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:11159866, PubMed:18597632, PubMed:26051469). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:26051469). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P97439", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:1904383 response to sodium phosphate;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030324 lung development;GO:0042476 odontogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P70669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H5X4-1", "uniprot_id": "PHF11_MOUSE", "mass": 37728.0, "length": 337, "protein_name": "PHD finger protein 11", "gene_name": "Phf11", "organism": "Mouse", "refseq_name": "PHD finger protein 11 isoform 2", "refseq_ac": "NP_950180", "gene_names_uniprotkb": "Phf11; D14Ertd668e; Phf11d; Phf11l", "gene_names_refseq": "D14Ertd668e; Phf11d; Phf11l; Phf11", "protein_names_uniprotkb": "PHD finger protein 11; PHD finger protein 11-like; PHD finger protein 11D", "protein_names_refseq": "PHD finger protein 11 family member; PHD finger protein 11 isoform 2", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); allergic disease (Disease Ontology:DOID:1205); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:219132)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25091723;31599954", "class_list": "", "function": "Only Phf11d is present in multiple mouse tissue cDNAs., [RefSeq, PubMed]; Positive regulator of Th1-type cytokine gene expression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0T6;Q8K2R8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6H5X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22005-1", "uniprot_id": "PENK_MOUSE", "mass": 31004.0, "length": 268, "protein_name": "Proenkephalin-A", "gene_name": "Penk", "organism": "Mouse", "refseq_name": "proenkephalin-A precursor", "refseq_ac": "NP_001002927", "gene_names_uniprotkb": "Penk; Penk1", "gene_names_refseq": "ENK; PPA; Penk1; Penk", "protein_names_uniprotkb": "Proenkephalin-A; BAM(8-22); Bovine adrenal medulla peptide 20; Bovine adrenal medulla peptide 22; Bovine adrenal medulla peptide 8-22; OGF; Opioid growth factor", "protein_names_refseq": "preproenkephalin 1; proenkephalin-A precursor; proenkephalin-A; spermatogenic-specific proenkephalin", "tax_id": 10090, "disease": "spinal disease (Disease Ontology:DOID:0060564); overactive bladder syndrome (Disease Ontology:DOID:0070355); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); dystonia (Disease Ontology:DOID:543); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18619); (R-MMU-375276); (R-MMU-381426); (R-MMU-418594); (R-MMU-8957275)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;2355920;25428506;2938259;30899004;31350433;35201898;6933569", "class_list": "", "function": "Increases glutamate release in the striatum and decreases GABA concentration in the striatum., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Increases glutamate release in the striatum., [UniProtKB, UniProtKB]; Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1 (PubMed:35201898, PubMed:6933569). Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release (PubMed:35201898)., [UniProtKB, PubMed, PubMed]; Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release., [UniProtKB, UniProtKB]; Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Neuropeptide that induces itch in a histamine-independent manner as well as nociceptive sensations (PubMed:31350433). Acts as a ligand for MRGPRX1 receptor in sensory neurons of dorsal root ganglion: MRGPRX1-binding in the peripheral nervous system elicits itch and scratching, while MRGPRX1-binding in the central nervous system dampens chronic pain (PubMed:31350433)., [UniProtKB, PubMed]; Neuropeptide that induces itch in a histamine-independent manner as well as nociceptive sensations. Acts as a ligand for MRGPRX1 receptor in sensory neurons of dorsal root ganglion: MRGPRX1-binding in the peripheral nervous system elicits itch and scratching, while MRGPRX1-binding in the central nervous system dampens chronic pain., [UniProtKB, UniProtKB]; Neuropeptide that mediates stress-induced opioid analgesia (By similarity). Also possesses non-opioid action by acting as a ligand for MRGPRX1 receptor to induce itch in a histamine-independent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Neuropeptide that mediates stress-induced opioid analgesia. Also possesses non-opioid action by acting as a ligand for MRGPRX1 receptor to induce itch in a histamine-independent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q68G73", "ec_number_list": "", "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0048018 receptor ligand activity;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001964 startle response;GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0032496 response to lipopolysaccharide;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P22005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35405-1", "uniprot_id": "PLD3_MOUSE", "mass": 54389.0, "length": 488, "protein_name": "5'-3' exonuclease PLD3", "gene_name": "Pld3", "organism": "Mouse", "refseq_name": "5'-3' exonuclease PLD3 isoform a", "refseq_ac": "NP_001304284", "gene_names_uniprotkb": "Pld3; Sam9", "gene_names_refseq": "Pld3; Sam-9", "protein_names_uniprotkb": "5'-3' exonuclease PLD3; (S,S)-bis(monoacylglycero)phosphate synthase PLD3; 2.3.1.-; 3.1.16.1; Phospholipase D3; SAM-9; Schwannoma-associated protein 9", "protein_names_refseq": "(S,S)-bis(monoacylglycero)phosphate synthase PLD3; 5'-3' exonuclease PLD3 isoform a; 5'-3' exonuclease PLD3; PLD 3; choline phosphatase 3; phosphatidylcholine-hydrolyzing phospholipase D3; phospholipase D3; schwannoma-associated protein 9", "tax_id": 10090, "disease": "spinocerebellar ataxia 46 (Disease Ontology:DOID:0080288)", "pathway": " (mmu:18807); (R-MMU-2029485)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11801660;19377048;21750661;22428023;25428506;28128235;29187734;29386126;30111894;30312375;30899004;32152506;33300544;34620855;36450991;38537643;39423811;9813063", "class_list": "", "function": "Can alternatively catalyze the transfer (transphosphatidylation) of a glycerol group between (S,R)-lysophosphatidylglycerol (LPG) and monoacylglycerol (MAG). The reaction is characterized by an R-to-S stereo-inversion which is essential for the resistance of the produced (S,S)-bis(monoacylglycero)phosphates (BMPs) to lysosomal degradation. The resulting BMPs, are phospholipids required for the formation of lysosomal intralumenal vesicles (ILVs) where lipid degradation can occur., [UniProtKB, PubMed]; Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal 5'->3' exonuclease that functions in nucleic-acid sensing by immune cells. Hydrolyzes phosphodiester bond in single-stranded RNA and DNA molecules, with a higher efficiency for molecules with 5' uridine and guanosine residues. It can stall at certain sites and does not necessarily proceed to complete exonucleolytic degradation, thereby producing nucleoside 3'-monophosphates but also 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments. Through the processing of self and exogenous RNA and DNA molecules, provides molecular signals to toll-like receptors (TLRs) in innate immunity (PubMed:30111894, PubMed:34620855, PubMed:38537643). Partially redundant with PLD4, it cooperates with the RNase T2/RNASET2 to generate 2',3'-cGMP and cytidine-rich RNA fragments that occupy the two TLR7 ligand-binding pockets, to trigger receptor activation and signaling. Degrades mitochondrial CpG-rich ssDNA fragments to prevent TLR9 activation and autoinflammatory response, but it can cleave viral RNA to generate ligands for TLR7 activation and initiate antiviral immune responses. Can exert polynucleotide phosphatase activity toward 5'-phosphorylated single-stranded DNA substrates although at a slow rate. Regulates the homeostasis and interorganellar communication of the endolysosomal system with an overall impact on cellular removal of dysfunctional organelles via autophagy as well as proper protein and lipid turnover. May play a role in myotube formation in response to ER stress (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; PLD3 affects axonal spheroids and network defects in Alzheimer's disease., [RefSeq, PubMed]; Pld3 expression is associated with hematopoietic stem cells that have durable self-renewal potential., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 21, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5M5", "ec_number_list": "2.3.1.-;3.1.16.1;3.1.4.4;3.1.4.-", "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0046872 metal ion binding;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0014902 myotube differentiation;GO:1900015 regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "O35405-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYT7-1", "uniprot_id": "PIGQ_MOUSE", "mass": 66264.0, "length": 581, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q", "gene_name": "Pigq", "organism": "Mouse", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 2", "refseq_ac": "NP_035952", "gene_names_uniprotkb": "Pigq; Gpi1h; Mgpi1", "gene_names_refseq": "Gpi1h; Gpi1p; Gpi1; Gpih; Pigq", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; MGpi1p; N-acetylglucosamyl transferase component GPI1; PIG-Q; Phosphatidylinositol-glycan biosynthesis class Q protein", "protein_names_refseq": "N-acetylglucosamyl transferase component GPI1; PIG-Q; phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 2; phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; phosphatidylinositol-glycan biosynthesis class Q protein", "tax_id": 10090, "disease": "multiple congenital anomalies-hypotonia-seizures syndrome 4 (Disease Ontology:DOID:0112213)", "pathway": " (mmu:14755); (R-MMU-162710)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10373468;21750661;34428180;9729469", "class_list": "glycogene;glycosyltransferase", "function": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35120;O35456;Q99L11", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QYT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07934-1", "uniprot_id": "PHKG1_MOUSE", "mass": 44960.0, "length": 388, "protein_name": "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform", "gene_name": "Phkg1", "organism": "Mouse", "refseq_name": "phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform", "refseq_ac": "NP_035209", "gene_names_uniprotkb": "Phkg1; Phkg", "gene_names_refseq": "Phkg1; Phkg", "protein_names_uniprotkb": "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; 2.7.11.19; 2.7.11.1; 2.7.11.26; Phosphorylase kinase subunit gamma-1; Serine/threonine-protein kinase PHKG1", "protein_names_refseq": "phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; phosphorylase kinase subunit gamma-1; serine/threonine-protein kinase PHKG1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18682); (R-MMU-70221)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;3472241;3597394;37507081;39927985;8486349", "class_list": "", "function": "Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.4.1.1;2.7.1.150", "go_molecular_function": "GO:0004689 phosphorylase kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07934-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0S0-1", "uniprot_id": "PHYIP_MOUSE", "mass": 37555.0, "length": 330, "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein", "gene_name": "Phyhip", "organism": "Mouse", "refseq_name": "phytanoyl-CoA hydroxylase-interacting protein", "refseq_ac": "NP_666093", "gene_names_uniprotkb": "Phyhip", "gene_names_refseq": "C630010D02Rik; Lnap1ip; PAHX-AP#1; PAHX-AP1; Phyhip", "protein_names_uniprotkb": "Phytanoyl-CoA hydroxylase-interacting protein; PAHX-AP1; PAHXAP1; Phytanoyl-CoA hydroxylase-associated protein 1", "protein_names_refseq": "PAHXAP1; lupus nephritis-associated peptide 1 interacting protein; phytanoyl-CoA hydroxylase-associated protein 1; phytanoyl-CoA hydroxylase-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:105653)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10686344;11245925;11527414;14672712;21750661;40885482", "class_list": "", "function": "Its interaction with PHYH suggests a role in the development of the central system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K0S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WW7-1", "uniprot_id": "PLPL3_MOUSE", "mass": 45772.0, "length": 413, "protein_name": "1-acylglycerol-3-phosphate O-acyltransferase Pnpla3", "gene_name": "Pnpla3", "organism": "Mouse", "refseq_name": "1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 1", "refseq_ac": "NP_473429", "gene_names_uniprotkb": "Pnpla3; Adpn", "gene_names_refseq": "Adpn; Pnpla3", "protein_names_uniprotkb": "1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; 2.3.1.51; 3.1.1.3; 3.1.1.4; ADPN; Acylglycerol transacylase; Adiponutrin; Calcium-independent phospholipase A2-epsilon; Lysophosphatidic acid acyltransferase; Patatin-like phospholipase domain-containing protein 3; iPLA2-epsilon", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 1; 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; acylglycerol O-acyltransferase; acylglycerol transacylase; adiponutrin; calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; lysophosphatidic acid acyltransferase; patatin-like phospholipase domain-containing protein 3", "tax_id": 10090, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypothyroidism (Disease Ontology:DOID:1459); coronary artery disease (Disease Ontology:DOID:3393); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:116939); (R-MMU-1482883)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11431482;16380488;20015565;20648554;21068004;21750661;22560221;33672787;35691594;37073116;37625151;38844467", "class_list": "", "function": "Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice., [RefSeq, PubMed]; Data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo, [RefSeq, PubMed]; Impact of PNPLA3 I148M on alpha-1 antitrypsin deficiency-dependent liver disease progression., [RefSeq, PubMed]; Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals., [RefSeq, PubMed]; Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice. Erratum:[Hepatology. 2010 Dec;52(6):2250], [RefSeq, PubMed]; Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1, SPOT14, and SCD1., [RefSeq, PubMed]; PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (By similarity). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (By similarity). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.51;3.1.1.5;3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.23;3.1.1.79;3.1.2.2;2.3.1.15;2.3.1.67;2.3.1.25;3.1.1.13;2.3.1.-;3.1.1.6;3.1.1.-;3.1.1.116", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0004623 phospholipase A2 activity;GO:0036042 long-chain fatty acyl-CoA binding;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0055088 lipid homeostasis;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91WW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0E1-1", "uniprot_id": "PLOD3_MOUSE", "mass": 84922.0, "length": 741, "protein_name": "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "gene_name": "Plod3", "organism": "Mouse", "refseq_name": "multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor", "refseq_ac": "NP_036092", "gene_names_uniprotkb": "Plod3", "gene_names_refseq": "LH3; Plod3", "protein_names_uniprotkb": "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Galactosylhydroxylysine-glucosyltransferase; LH3; Lysyl hydroxylase 3; Procollagen galactosyltransferase; Procollagen glucosyltransferase", "protein_names_refseq": "lysyl hydroxylase 2; lysyl hydroxylase 3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "tax_id": 10090, "disease": "BCARD syndrome (Disease Ontology:DOID:0061197); hypothyroidism (Disease Ontology:DOID:1459); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:26433); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10429951;11334715;15377789;16447251;16467571;17873278;19349973;21220425;21465473;21750661;23209641;25419660;25428506;26740625;30084848;30516406;30779550;30899004;31219806;31599954;34428180;36210013;37828378", "class_list": "glycogene;glycosyltransferase", "function": "Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen (PubMed:16447251). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:16447251). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:16447251, PubMed:16467571, PubMed:21220425). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:23209641). Essential for normal biosynthesis and secretion of type IV collagens (PubMed:15377789, PubMed:16467571, PubMed:17873278). Essential for normal formation of basement membranes (PubMed:15377789, PubMed:16467571)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results demonstrate that LH3 is indispensable for biosynthesis of type IV collagen and for basement membrane stability during early development and that loss of LH3's functions leads to embryonic lethality, [RefSeq, PubMed]; Results indicate that LH3 overexpression attenuates susceptibility to hypertensive intracerebral hemorrhage, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q542E0;Q9CYY9", "ec_number_list": "2.4.1.50;1.14.11.4;2.4.1.66", "go_molecular_function": "GO:0005506 iron ion binding;GO:0046872 metal ion binding;GO:0031418 L-ascorbic acid binding;GO:0036094 small molecule binding;GO:0008475 procollagen-lysine 5-dioxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006493 protein O-linked glycosylation;GO:0042311 vasodilation;GO:0030199 collagen fibril organization;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9R0E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11247-1", "uniprot_id": "PERM_MOUSE", "mass": 81182.0, "length": 718, "protein_name": "Myeloperoxidase", "gene_name": "Mpo", "organism": "Mouse", "refseq_name": "myeloperoxidase precursor", "refseq_ac": "NP_034954", "gene_names_uniprotkb": "Mpo", "gene_names_refseq": "Mpo; mKIAA4033", "protein_names_uniprotkb": "Myeloperoxidase; 1.11.2.2; MPO", "protein_names_refseq": "myeloperoxidase precursor", "tax_id": 10090, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); keratosis (Disease Ontology:DOID:161); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); bacterial pneumonia (Disease Ontology:DOID:874); status asthmaticus (Disease Ontology:DOID:9362)", "pathway": " (mmu:17523); (R-MMU-6798695); (R-MMU-8941413)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10085024;11593004;21750661;22955884;23306200;2548170;2552419;30899004;31358739;32152506;33234591;38910308;39627609", "class_list": "", "function": "Heavy chain of the mature myeloperoxidase., [UniProtKB, UniProtKB]; Light chain of the mature myeloperoxidase., [UniProtKB, UniProtKB]; NOX4 and its association with myeloperoxidase and osteopontin in regulating endochondral ossification., [RefSeq, PubMed]; Peroxidase that plays a central role in the host defense system of polymorphonuclear leukocytes by mediating both (1) formation of neutrophil extracellular trap (NETs) and (2) microbicidal activity (PubMed:10085024, PubMed:11593004, PubMed:23306200). Promotes NET formation by mediating chromatin disassembly: translocates to the nucleus and specifically binds to nucleosomes, both as monomer and homodimer, leading to nucleosome unstacking and initial chromatin decondensation (By similarity). Homodimers clash with one end of the nucleosomal DNA, leading to DNA unwrapping, initiating complete disassembly of nucleosomes and chromatin transformation into NETs in an ATP-independent manner (By similarity). NETs, which are mainly composed of DNA fibers and globular proteins, are then extruded into the extracellular space by neutrophils to trap pathogens and release antimicrobial proteins to destroy them (By similarity). Participates to the microbicidal activity against a wide range of organisms by acting as a peroxidase that catalyzes the formation of oxidants in presence of hydrogen peroxide (PubMed:11593004). Mediates the formation of hypohalous acids, mainly hypochlorous acid (HOCl) in physiologic situations, that greatly enhance polymorphonuclear leukocyte microbicidal activity (PubMed:11593004, PubMed:23306200). In addition to hypochlorous acid, catalyzes formation of hypobromous acid (HOBr), hypoiodous acid (HOI) and hypothiocyanous acid (HOSCN) (By similarity). Also catalyzes oxidation of nitrite into the highly reactive nitrogen dioxide radical (By similarity). Formation of oxidants are widely believed to be responsible for much of the anti-bactericidal activity of neutrophils (By similarity). Oxidants, such as hypochlorous acid or nitrogen dioxide radical, can also oxidize amino acid residues on proteins and generate chlorination and nitration post-translational modifications, respectively (By similarity). Chlorination and nitration of the lipid-free form of APOA1 impairs cholesterol transport (By similarity). Superoxides generated by MPO can also promote dioxygenation of tryptophan residues on proteins (By similarity). Also able to oxidize melatonin into N1-acetyl-N2-formyl-5-methoxykynuramine either in presence of hydrogen peroxide or superoxide (By similarity). Oxidizes urate into 5-hydroxyisourate (By similarity). Functions as a nitric oxide (NO) oxidase during inflammation, by catalytically consuming NO, impairing NO's ability to maintain vascular tone and function (By similarity). May also mediate the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 21, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCP1", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.11.1.7;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;1.11.2.-;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031491 nucleosome binding;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0030141 secretory granule", "go_biological_process": "GO:0070947 neutrophil-mediated killing of fungus;GO:0001878 response to yeast;GO:0006979 response to oxidative stress;GO:0032496 response to lipopolysaccharide;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P11247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70591-1", "uniprot_id": "PFD2_MOUSE", "mass": 16534.0, "length": 154, "protein_name": "Prefoldin subunit 2", "gene_name": "Pfdn2", "organism": "Mouse", "refseq_name": "prefoldin subunit 2 isoform 1", "refseq_ac": "NP_035200", "gene_names_uniprotkb": "Pfdn2; Pfd2", "gene_names_refseq": "ESTM27; Pfdn2", "protein_names_uniprotkb": "Prefoldin subunit 2", "protein_names_refseq": "prefoldin subunit 2 isoform 1; prefoldin subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18637)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18250455;21750661;26663874;30084848;30779550;32848054;34428180;9630229", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB, UniProtKB]; Knocking down prefoldin-2 (Pfdn2) expression in primary murine retinal ganglion cells(RGCs) significantly reduced Sncg expression, confirming that Pfdn2 regulates Sncg expression in murine RGCs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0H2", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051495 positive regulation of cytoskeleton organization;GO:0006457 protein folding;GO:1905907 negative regulation of amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70591-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q11136-1", "uniprot_id": "PEPD_MOUSE", "mass": 55029.0, "length": 493, "protein_name": "Xaa-Pro dipeptidase", "gene_name": "Pepd", "organism": "Mouse", "refseq_name": "xaa-Pro dipeptidase isoform 1", "refseq_ac": "NP_032846", "gene_names_uniprotkb": "Pepd; Pep4", "gene_names_refseq": "Pep-4; Pep4; Pepd; dal", "protein_names_uniprotkb": "Xaa-Pro dipeptidase; 3.4.13.9; Imidodipeptidase; Peptidase 4; Peptidase D; Prolidase; Proline dipeptidase; X-Pro dipeptidase", "protein_names_refseq": "X-pro dipeptidase; imidodipeptidase; peptidase 4; prolidase; proline dipeptidase; xaa-Pro dipeptidase isoform 1; xaa-Pro dipeptidase", "tax_id": 10090, "disease": "prolidase deficiency (Disease Ontology:DOID:0111540); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (mmu:18624)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;28528544;31246278;35478031;36637239;8765744", "class_list": "", "function": "Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen., [UniProtKB, UniProtKB]; Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance., [RefSeq, PubMed]; Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity., [RefSeq, PubMed]; Prolidase enzyme is required for extracellular matrix integrity and impacts on postnatal cerebellar cortex development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97735;Q3TH86;Q9CWK4", "ec_number_list": "3.4.13.9", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity;GO:0102009 proline dipeptidase activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0030574 collagen catabolic process;GO:0140633 CARD8 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q11136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35419-1", "uniprot_id": "PERT_MOUSE", "mass": 101342.0, "length": 914, "protein_name": "Thyroid peroxidase", "gene_name": "Tpo", "organism": "Mouse", "refseq_name": "thyroid peroxidase precursor", "refseq_ac": "NP_033443", "gene_names_uniprotkb": "Tpo", "gene_names_refseq": "Tpo", "protein_names_uniprotkb": "Thyroid peroxidase; 1.11.1.8; TPO", "protein_names_refseq": "thyroid peroxidase precursor", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 2A (Disease Ontology:DOID:0112186); glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (mmu:22018); (R-MMU-209968)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15311276;21750661;24297261;31219806;35820727;7916704", "class_list": "", "function": "Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene., [RefSeq, PubMed]; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)., [UniProtKB, UniProtKB]; This gene encodes a membrane-bound glycoprotein. The encoded enzyme plays a central role in thyroid gland function. The enzyme functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mice with homozygous missense mutations in this gene exhibit hypothyroid dwarfism and hearing impairment. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8B1", "ec_number_list": "1.6.3.1;1.11.1.-;1.-.-.-;1.11.1.8", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0004447 iodide peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0006979 response to oxidative stress;GO:0042446 hormone biosynthetic process;GO:0042744 hydrogen peroxide catabolic process;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35419-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62087-1", "uniprot_id": "PON3_MOUSE", "mass": 39351.0, "length": 354, "protein_name": "Serum paraoxonase/lactonase 3", "gene_name": "Pon3", "organism": "Mouse", "refseq_name": "serum paraoxonase/lactonase 3 isoform 1", "refseq_ac": "NP_766594", "gene_names_uniprotkb": "Pon3", "gene_names_refseq": "2810004E20; Pon3", "protein_names_uniprotkb": "Serum paraoxonase/lactonase 3; 3.1.1.2; 3.1.1.81; 3.1.8.1", "protein_names_refseq": "serum paraoxonase/lactonase 3 isoform 1; serum paraoxonase/lactonase 3", "tax_id": 10090, "disease": "celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); atherosclerosis (Disease Ontology:DOID:1936); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:269823); (R-MMU-2142688); (R-MMU-9754706)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15963993;21750661;32079677;34428180;37507081;38345534;8661009", "class_list": "", "function": "Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity)., [UniProtKB]; Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel., [RefSeq, PubMed]; Role of paraoxonase 3 in regulating ENaC-mediated Na[+] transport in the distal nephron., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZK0;Q8C2I7", "ec_number_list": "3.1.1.2;3.1.1.81;3.1.8.1", "go_molecular_function": "GO:0004063 aryldialkylphosphatase activity;GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity;GO:0047856 dihydrocoumarin hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0046395 carboxylic acid catabolic process;GO:0010124 phenylacetate catabolic process;GO:0032929 negative regulation of superoxide anion generation;GO:0009636 response to toxic substance;GO:0046226 coumarin catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXA7-1", "uniprot_id": "PHLP2_MOUSE", "mass": 145947.0, "length": 1320, "protein_name": "PH domain leucine-rich repeat-containing protein phosphatase 2", "gene_name": "Phlpp2", "organism": "Mouse", "refseq_name": "PH domain leucine-rich repeat-containing protein phosphatase 2", "refseq_ac": "NP_001116066", "gene_names_uniprotkb": "Phlpp2; Phlppl", "gene_names_refseq": "C130044A18Rik; Phlpp2; Phlppl", "protein_names_uniprotkb": "PH domain leucine-rich repeat-containing protein phosphatase 2; 3.1.3.16; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like", "protein_names_refseq": "GTPase activating protein and VPS9 domains 1; PH domain leucine-rich repeat-containing protein phosphatase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244650); (R-MMU-199418)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "20089132;21183079;21750661;24530606;25428506;31219806;34428180;36376971;37474690", "class_list": "", "function": "Knockdown of Mmu-circ-0001380 Attenuates Myocardial Ischemia/Reperfusion Injury via Modulating miR-106b-5p/Phlpp2 Axis., [RefSeq, PubMed]; PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice., [RefSeq, PubMed]; PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148U6;Q8BX96", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.7.11.1;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0045171 intercellular bridge", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006470 protein dephosphorylation;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BXA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35690-1", "uniprot_id": "PHX2B_MOUSE", "mass": 31621.0, "length": 314, "protein_name": "Paired mesoderm homeobox protein 2B", "gene_name": "Phox2b", "organism": "Mouse", "refseq_name": "paired mesoderm homeobox protein 2B", "refseq_ac": "NP_032914", "gene_names_uniprotkb": "Phox2b; Pmx2b", "gene_names_refseq": "Dilp1; NBPhox; Phox2b; Pmx2b; Px2b", "protein_names_uniprotkb": "Paired mesoderm homeobox protein 2B; NBPhox; Neuroblastoma Phox; PHOX2B homeodomain protein; Paired-like homeobox 2B", "protein_names_refseq": "GENA 269; PHOX2B homeodomain protein; dilated pupils 1; neuroblastoma Phox; paired mesoderm homeobox 2b; paired mesoderm homeobox protein 2B", "tax_id": 10090, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731); neuroblastoma (Disease Ontology:DOID:769); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:18935)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10395798;18275850;200898;32094113;9374403", "class_list": "", "function": "Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus (PubMed:32094113). Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element., [UniProtKB, PubMed]; Phox2b-variants (wt and neuroblastoma related) affect proliferation of cultured sympathetic precursors. Phox2b variants directly interact with the bHLH transcription factor Hand2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0003360 brainstem development;GO:0048484 enteric nervous system development;GO:0048483 autonomic nervous system development;GO:0021723 medullary reticular formation development;GO:0021934 hindbrain tangential cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35690-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70362-1", "uniprot_id": "PHLD_MOUSE", "mass": 93255.0, "length": 837, "protein_name": "Phosphatidylinositol-glycan-specific phospholipase D", "gene_name": "Gpld1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gpld1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol-glycan-specific phospholipase D; 3.1.4.50; GPI-PLD; GPI-specific phospholipase D; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; PI-G PLD", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-163125)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17330941;17720976;20571061;30084848;30899004;34428180;9716655", "class_list": "glycogene", "function": "Hydrolyzes the inositol phosphate linkage of glycosylphosphatidylinositol (GPI)-anchored membrane proteins, thereby releasing them from the cell surface. Cleaves on the inositol side of the anchor, leaving the phosphate group attached to the membrane (PubMed:17720976). This release of GPI-anchored proteins can modulate diverse biological processes, including the activation of signaling pathways (PubMed:17720976)., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 1128, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.11.9;3.1.3.1;3.1.4.50;3.9.1.1;3.2.2.6;3.4.17.12;2.4.2.31;3.4.21.-;3.5.1.92", "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0004621 glycosylphosphatidylinositol phospholipase D activity;GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0071401 cellular response to triglyceride;GO:1900076 regulation of cellular response to insulin stimulus;GO:0006629 lipid metabolic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O70362-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88593-1", "uniprot_id": "PGRP1_MOUSE", "mass": 20489.0, "length": 182, "protein_name": "Peptidoglycan recognition protein 1", "gene_name": "Pglyrp1", "organism": "Mouse", "refseq_name": "peptidoglycan recognition protein 1 precursor", "refseq_ac": "NP_033428", "gene_names_uniprotkb": "Pglyrp1; Pglyrp; Pgrps; Pgrp; Tag7", "gene_names_refseq": "PGRP-S; PGRP; Pglyrp1; Pglyrp; Tag7; Tasg7; Tnfsf3l", "protein_names_uniprotkb": "Peptidoglycan recognition protein 1; Cytokine tag7; PGRP-S; Peptidoglycan recognition protein short", "protein_names_refseq": "cytokine tag7; peptidoglycan recognition protein 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:21946); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12649138;14585845;37828379;38393947;38754953;9660837;9707603", "class_list": "", "function": "Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:12649138, PubMed:9660837, PubMed:9707603). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed:14585845). In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation., [RefSeq, PubMed]; The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells. Erratum:[Gut. 2024 Dec 10;74(1):e11. doi: 10.1136/gutjnl-2023-330995corr1. PMID: 39658261] Publication Status: Online-Only, [RefSeq, PubMed]; The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62185", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0032827 negative regulation of natural killer cell differentiation involved in immune response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88593-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22437-1", "uniprot_id": "PGH1_MOUSE", "mass": 69042.0, "length": 602, "protein_name": "Prostaglandin G/H synthase 1", "gene_name": "Ptgs1", "organism": "Mouse", "refseq_name": "prostaglandin G/H synthase 1 precursor", "refseq_ac": "NP_032995", "gene_names_uniprotkb": "Ptgs1; Cox-1; Cox1", "gene_names_refseq": "COX1; Cox-1; Cox-3; PGHS-1; PHS 1; Pghs1; Ptgs1", "protein_names_uniprotkb": "Prostaglandin G/H synthase 1; 1.14.99.1; COX-1; Cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1", "protein_names_refseq": "PGH synthase 1; cyclooxygenase-1; prostaglandin G/H synthase 1 precursor; prostaglandin G/H synthase 1; prostaglandin H2 synthase 1", "tax_id": 10090, "disease": "salivary gland carcinoma (Disease Ontology:DOID:0050904); polycystic kidney disease (Disease Ontology:DOID:0080322); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hepatic encephalopathy (Disease Ontology:DOID:13413); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893); glioblastoma (Disease Ontology:DOID:3068); gliosarcoma (Disease Ontology:DOID:3071); bipolar disorder (Disease Ontology:DOID:3312); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:19224); (R-MMU-140180); (R-MMU-2162123)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10966456;20484733;2108169;24605250;25428506;25428507;27802388;30084848;30779550;31599954;34428180;35820727;36210013;40997131;8121489;9751758", "class_list": "", "function": "Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products., [UniProtKB, UniProtKB]; Prostaglandin G/H synthase is a moonlighting protein that functions both as a peroxidase as well as a cyclooxygenase., [RefSeq, PubMed]; This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.99.1", "go_molecular_function": "GO:0004666 prostaglandin-endoperoxide synthase activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007612 learning;GO:0007613 memory;GO:0042127 regulation of cell population proliferation;GO:0045987 positive regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P22437-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28653-1", "uniprot_id": "PGS1_MOUSE", "mass": 41639.0, "length": 369, "protein_name": "Biglycan", "gene_name": "Bgn", "organism": "Mouse", "refseq_name": "biglycan isoform 2 preproprotein", "refseq_ac": "NP_031568", "gene_names_uniprotkb": "Bgn", "gene_names_refseq": "BG; Bgn; DSPG1; PG-S1; PGI; SLRR1A", "protein_names_uniprotkb": "Biglycan; Bone/cartilage proteoglycan I; PG-S1", "protein_names_refseq": "biglycan isoform 2 preproprotein; bone/cartilage proteoglycan I", "tax_id": 10090, "disease": "Meester-Loeys syndrome (Disease Ontology:DOID:0111861); X-linked spondyloepimetaphyseal dysplasia (Disease Ontology:DOID:0112150); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:12111); (R-MMU-1971475); (R-MMU-2022870); (R-MMU-2022923); (R-MMU-2024101); (R-MMU-3000178)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11311118;34428180;37507081;37828378;8043960", "class_list": "glycogene", "function": "May be involved in collagen fiber assembly., [UniProtKB]; This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61355", "ec_number_list": "", "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0019955 cytokine binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0030133 transport vesicle;GO:0042383 sarcolemma", "go_biological_process": "GO:0001974 blood vessel remodeling;GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P28653-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55098-1", "uniprot_id": "PEX2_MOUSE", "mass": 34732.0, "length": 305, "protein_name": "Peroxisome biogenesis factor 2", "gene_name": "Pex2", "organism": "Mouse", "refseq_name": "peroxisome biogenesis factor 2", "refseq_ac": "NP_001156773", "gene_names_uniprotkb": "Pex2; Paf1; Pmp35; Pxmp3", "gene_names_refseq": "D3Ertd138e; PAF-1; PMP35; Pex2; Pxmp3", "protein_names_uniprotkb": "Peroxisome biogenesis factor 2; 2.3.2.27; 2.3.2.36; PAF-1; Peroxin-2; Peroxisomal membrane protein 3; Peroxisome assembly factor 1", "protein_names_refseq": "Zellweger syndrome homolog; peroxin-2; peroxisomal membrane protein 3, 35 kDa; peroxisome assembly factor 1; peroxisome biogenesis factor 2", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 5A (Disease Ontology:DOID:0080480); Peroxisome biogenesis disorder 5B (Disease Ontology:DOID:0081434); Zellweger syndrome (Disease Ontology:DOID:905); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (mmu:19302); (R-MMU-8866654); (R-MMU-9033241); (R-MMU-9603798)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12746876;14673138;19110480;22441164;33163488;34903883;8043297;9382874", "class_list": "", "function": "E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (By similarity). Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35467", "ec_number_list": "2.3.2.27;5.1.99.4;1.14.11.18;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;1.2.1.3;1.2.1.94;2.3.1.137;2.3.1.7;7.6.2.-;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.2.24;2.3.2.23;2.3.1.42;3.6.4.-;2.5.1.26;1.5.3.13;2.3.1.9;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;7.4.2.-;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0000151 ubiquitin ligase complex;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0043335 protein unfolding;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P55098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70182-1", "uniprot_id": "PI51A_MOUSE", "mass": 60485.0, "length": 546, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha", "gene_name": "Pip5k1a", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1", "refseq_ac": "NP_001280636", "gene_names_uniprotkb": "Pip5k1a", "gene_names_refseq": "PI4P5K-I[a]; PIP5K1-alpha; PIP5KIalpha; Pip5k1a; Pipk5a", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; 2.7.1.68; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; PI4P5KIbeta; PIP5K1-alpha; PIP5KIalpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Phosphatidylinositol 4-phosphate 5-kinase type I beta; PtdIns(4)P-5-kinase 1 alpha", "protein_names_refseq": "68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1; ptdIns(4)P-5-kinase 1 alpha", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18720); (R-MMU-1660499); (R-MMU-6811558)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10679324;18772378;19153220;20622009;21750661;27739494;28711717;29426367;31599954;34428180;34624591;37828378;8798574;9535851", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8798574, PubMed:9535851). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (PubMed:18772378). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (By similarity). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (PubMed:19153220). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (PubMed:19153220). Together with PIP5K1B, is required, after stimulation by G protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (By similarity). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (PubMed:27739494). Together with PIP5K1C has a role during embryogenesis (PubMed:20622009). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:10679324). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha confined to the surface of lipid droplets and adjacent narrow cytoplasm in progesterone-producing cells of in situ ovaries of adult mice., [RefSeq, PubMed]; PIP5K1alpha was found to be required for AKT activation and calcium release, both of which were important for skeletal muscle differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; These results support that PIP5Kalpha can positively mediate TLR2-associated immune responses through Phosphatidylinositol 4,5-bisphosphate production in microglial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8WIX5;Q3U917;Q8K0D3;Q99L80", "ec_number_list": "2.7.1.68;2.7.1.149", "go_molecular_function": "GO:0005524 ATP binding;GO:0019900 kinase binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0030036 actin cytoskeleton organization;GO:0060326 cell chemotaxis;GO:0048041 focal adhesion assembly;GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P70182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08024-1", "uniprot_id": "PEBB_MOUSE", "mass": 22030.0, "length": 187, "protein_name": "Core-binding factor subunit beta", "gene_name": "Cbfb", "organism": "Mouse", "refseq_name": "core-binding factor subunit beta isoform 2", "refseq_ac": "NP_001154928", "gene_names_uniprotkb": "Cbfb; Pebp2b; Pebpb2", "gene_names_refseq": "Cbfb; PEA2; PEBP2b; Pebp2; Pebpb2", "protein_names_uniprotkb": "Core-binding factor subunit beta; CBF-beta; PEA2-beta; PEBP2-beta; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit", "protein_names_refseq": "CBF-beta; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; core-binding factor subunit beta isoform 2; core-binding factor subunit beta; polyomavirus enhancer-binding protein 2 beta subunit", "tax_id": 10090, "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); cleidocranial dysplasia (Disease Ontology:DOID:13994); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12400); (R-MMU-8877330); (R-MMU-8878166); (R-MMU-8931987); (R-MMU-8934593); (R-MMU-8936459); (R-MMU-8939236); (R-MMU-8939243); (R-MMU-8939245); (R-MMU-8939246); (R-MMU-8939247); (R-MMU-8941326); (R-MMU-8941858); (R-MMU-8951936); (R-MMU-9018519)", "pathway_count": 15, "publication_count": 9, "publication_id_list": "10404216;11257229;11560490;12434156;18258917;22193545;31219806;8386878;8497254", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3) (PubMed:12434156, PubMed:8386878, PubMed:8497254). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX (PubMed:12434156, PubMed:8386878, PubMed:8497254). The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (PubMed:11257229). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development (PubMed:18258917). They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08025;Q62050;Q62051;Q8C282;Q8CGD5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0016513 core-binding factor complex", "go_biological_process": "GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UNN8-1", "uniprot_id": "PLD5_MOUSE", "mass": 61066.0, "length": 536, "protein_name": "Inactive phospholipase D5", "gene_name": "Pld5", "organism": "Mouse", "refseq_name": "inactive phospholipase D5 isoform 2", "refseq_ac": "NP_001182745", "gene_names_uniprotkb": "Pld5", "gene_names_refseq": "B230365F16Rik; Pld5", "protein_names_uniprotkb": "Inactive phospholipase D5; Inactive PLD 5; Inactive choline phosphatase 5; Inactive phosphatidylcholine-hydrolyzing phospholipase D5", "protein_names_refseq": "inactive PLD 5; inactive choline phosphatase 5; inactive phosphatidylcholine-hydrolyzing phospholipase D5; inactive phospholipase D5 isoform 2; inactive phospholipase D5; phospholipase D5", "tax_id": 10090, "disease": "", "pathway": " (mmu:319455)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVW3;Q497Q7", "ec_number_list": "", "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UNN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1D5-1", "uniprot_id": "PLPL1_MOUSE", "mass": 65170.0, "length": 599, "protein_name": "Omega-hydroxyceramide transacylase", "gene_name": "Pnpla1", "organism": "Mouse", "refseq_name": "omega-hydroxyceramide transacylase", "refseq_ac": "NP_001030057", "gene_names_uniprotkb": "Pnpla1", "gene_names_refseq": "Pnpla1", "protein_names_uniprotkb": "Omega-hydroxyceramide transacylase; 2.3.1.296; Patatin-like phospholipase domain-containing protein 1", "protein_names_refseq": "omega-hydroxyceramide transacylase; patatin-like phospholipase domain-containing protein 1", "tax_id": 10090, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); autosomal recessive congenital ichthyosis 10 (Disease Ontology:DOID:0060719); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:433091)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;27267404;27751867;28248300;34428180;36116510", "class_list": "", "function": "ALOX12B and PNPLA1 Have Distinct Roles in Epidermal Lipid Lamellar Organization., [RefSeq, PubMed]; An essential role of PNPLA1 in the synthesis of omega-O-AcylCers in human and murine skin., [RefSeq, PubMed]; Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation (PubMed:27751867, PubMed:28248300). Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide (PubMed:27751867, PubMed:28248300). Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function (PubMed:27751867, PubMed:28248300). These lipids also play a role in keratinocyte differentiation (PubMed:28248300). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (PubMed:28248300)., [UniProtKB, PubMed, PubMed]; PNPLA1 catalyses the omega-O-esterification with linoleic acid to form acylceramides. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate PNPLA1 is a skin-specific and membrane-associated protein, suggesting that it may mainly play a role in the skin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.296", "go_molecular_function": "GO:0004806 triacylglycerol lipase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0030280 structural constituent of skin epidermis;GO:0106341 omega-hydroxyceramide transacylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0055088 lipid homeostasis;GO:0061436 establishment of skin barrier;GO:0030216 keratinocyte differentiation;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3V1D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61469-1", "uniprot_id": "PLPP1_MOUSE", "mass": 31892.0, "length": 283, "protein_name": "Phospholipid phosphatase 1", "gene_name": "Plpp1", "organism": "Mouse", "refseq_name": "phospholipid phosphatase 1 isoform 1", "refseq_ac": "NP_032273", "gene_names_uniprotkb": "Plpp1; Hpic53; Lpp1; Ppap2a", "gene_names_refseq": "Hic53; Hpic53; LPP-1; LPP1; PAP-2a; PAP2-alpha; PAP2a; Plpp1; Ppap2a; mPAP", "protein_names_uniprotkb": "Phospholipid phosphatase 1; 3.1.3.-; 3.1.3.106; 3.1.3.4; 3.6.1.75; 35 kDa PAP; Hic53; Hydrogen peroxide-inducible protein 53; Lipid phosphate phosphohydrolase 1; PAP-2a; PAP2-alpha; PAP2a; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; mPAP", "protein_names_refseq": "35 kDa PAP; hydrogen peroxide inducible protein 53; lipid phosphate phosphohydrolase 1; phosphatidate phosphohydrolase type 2a; phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A; phospholipid phosphatase 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19012); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10359651;10620492;10818444;11535125;14687668;14725715;15461590;17057224;17379599;19144319;19215222;25210149;25769037;28273928;28528544;7556647;8702556", "class_list": "glycogene", "function": "Data identify a novel role for phospholipid phosphate phosphatase type 1 activity and hepatocyte lysophosphatidic acid levels in glucagon sensitivity via a mechanism involving STAT3. Publication Status: Online-Only, [RefSeq, PubMed]; Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1. Publication Status: Online-Only, [RefSeq, PubMed]; Increasing the LPP1 activity in three lines of aggressive cancer cells decreases their abilities to produce tumors and metastases, [RefSeq, PubMed]; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:10359651, PubMed:10620492, PubMed:10818444, PubMed:15461590, PubMed:19215222, PubMed:8702556). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:15461590, PubMed:17057224). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (PubMed:17057224)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61690;Q6GT30;Q8BPB8", "ec_number_list": "3.3.2.10;3.1.3.76;3.1.3.4;3.6.1.75;3.1.3.-;3.1.3.106;3.1.3.5;3.1.3.2;3.1.3.48;3.6.1.-;3.6.1.68", "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0006672 ceramide metabolic process;GO:0006651 diacylglycerol biosynthetic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61469-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M6Y3-1", "uniprot_id": "PICAL_MOUSE", "mass": 71543.0, "length": 660, "protein_name": "Phosphatidylinositol-binding clathrin assembly protein", "gene_name": "Picalm", "organism": "Mouse", "refseq_name": "phosphatidylinositol-binding clathrin assembly protein isoform 2", "refseq_ac": "NP_001239449", "gene_names_uniprotkb": "Picalm; Calm; Fit1", "gene_names_refseq": "CALM; CLTH; PAP180; Picalm; fit-1; fit1; mKIAA4114", "protein_names_uniprotkb": "Phosphatidylinositol-binding clathrin assembly protein; CALM; Clathrin assembly lymphoid myeloid leukemia", "protein_names_refseq": "clathrin assembly lymphoid myeloid leukemia; phosphatidylinositol-binding clathrin assembly protein isoform 2", "tax_id": 10090, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:233489); (R-MMU-432722); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9696264)", "pathway_count": 5, "publication_count": 33, "publication_id_list": "10.3389/fragi.2021.757801;12832620;17242355;18250455;18299400;19224205;20173027;21750661;21952136;22363754;22517741;22645316;25428506;25428507;25605945;26495903;30059200;30084848;30779550;31219806;31616917;32782141;32848054;34428180;34678516;35820727;35984892;36852467;37828378;38237377;39182843;40997131;9292517", "class_list": "", "function": "Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF)., [UniProtKB, PubMed, UniProtKB, PubMed]; MiR-155-5p promotes hepatic steatosis via PICALM-mediated autophagy in aging hepatocytes., [RefSeq, PubMed]; Picalm, a novel regulator of GLUT4-trafficking in adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 24, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 24, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 24, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS04;Q811P1;Q8BUF6;Q8CIH8;Q8R0A9;Q8R3E1;Q8VDN5;Q921L0", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0048156 tau protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:1903861 positive regulation of dendrite extension;GO:0097753 membrane bending;GO:0051223 regulation of protein transport;GO:1900244 positive regulation of synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "Q7M6Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPN3-1", "uniprot_id": "PIGV_MOUSE", "mass": 55026.0, "length": 493, "protein_name": "GPI alpha-1,6-mannosyltransferase 2", "gene_name": "Pigv", "organism": "Mouse", "refseq_name": "GPI alpha-1,6-mannosyltransferase 2 isoform 2", "refseq_ac": "NP_001139427", "gene_names_uniprotkb": "Pigv", "gene_names_refseq": "B330013B03; D430024F16Rik; Pigv", "protein_names_uniprotkb": "GPI alpha-1,6-mannosyltransferase 2; 2.4.1.-; GPI mannosyltransferase II; GPI-MT-II; PIG-V; Phosphatidylinositol-glycan biosynthesis class V protein", "protein_names_refseq": "GPI alpha-1,6-mannosyltransferase 2 isoform 2; GPI alpha-1,6-mannosyltransferase 2; GPI mannosyltransferase 2; GPI mannosyltransferase II; GPI-MT-II; PIG-V; phosphatidylinositol glycan, class V; phosphatidylinositol-glycan biosynthesis class V protein", "tax_id": 10090, "disease": "hyperphosphatasia with impaired intellectual development syndrome 1 (Disease Ontology:DOID:0070433)", "pathway": " (mmu:230801); (R-MMU-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30779550;33402532", "class_list": "glycogene;glycosyltransferase", "function": "A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions., [RefSeq, PubMed]; Alpha-1,6-mannosyltransferase that catalyzes the transfer of the second mannose, via an alpha-1,6 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) and participates in the seventh step of the glycosylphosphatidylinositol-anchor biosynthesis (By similarity). May also transfer the second mannose on a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H5), but less effectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGL2;Q8BJR5;Q8BWH9;Q8BXF5", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0000009 alpha-1,6-mannosyltransferase activity;GO:0120563 dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TPN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJI4-1", "uniprot_id": "PO6F2_MOUSE", "mass": 73309.0, "length": 691, "protein_name": "POU domain, class 6, transcription factor 2", "gene_name": "Pou6f2", "organism": "Mouse", "refseq_name": "POU domain, class 6, transcription factor 2", "refseq_ac": "NP_778171", "gene_names_uniprotkb": "Pou6f2", "gene_names_refseq": "D130006K24Rik; Pou6f2; RPF-1", "protein_names_uniprotkb": "POU domain, class 6, transcription factor 2", "protein_names_refseq": "POU domain, class 6, transcription factor 2; retina-derived POU-domain factor-1", "tax_id": 10090, "disease": "nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (mmu:218030)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11284034;21750661", "class_list": "", "function": "Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3' (By similarity)., [UniProtKB]; Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3')., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BJI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP56-1", "uniprot_id": "PGGHG_MOUSE", "mass": 76488.0, "length": 690, "protein_name": "Protein-glucosylgalactosylhydroxylysine glucosidase", "gene_name": "Pgghg", "organism": "Mouse", "refseq_name": "protein-glucosylgalactosylhydroxylysine glucosidase", "refseq_ac": "NP_663362", "gene_names_uniprotkb": "Pgghg; Athl1", "gene_names_refseq": "5730511L01Rik; Athl1; Pgghg", "protein_names_uniprotkb": "Protein-glucosylgalactosylhydroxylysine glucosidase; 3.2.1.107; Acid trehalase-like protein 1", "protein_names_refseq": "ATH1, acid trehalase-like 1; acid trehalase-like protein 1; mFLJ00228 protein; protein-glucosylgalactosylhydroxylysine glucosidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:212974)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q571E9;Q8R585", "ec_number_list": "3.2.1.107", "go_molecular_function": "GO:0047402 protein-glucosylgalactosylhydroxylysine glucosidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BP56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTP0-1", "uniprot_id": "PIGZ_MOUSE", "mass": 62043.0, "length": 560, "protein_name": "GPI alpha-1,2-mannosyltransferase 4", "gene_name": "Pigz", "organism": "Mouse", "refseq_name": "GPI alpha-1,2-mannosyltransferase 4", "refseq_ac": "NP_766410", "gene_names_uniprotkb": "Pigz", "gene_names_refseq": "F630022B06Rik; Pigz", "protein_names_uniprotkb": "GPI alpha-1,2-mannosyltransferase 4; 2.4.1.-; GPI mannosyltransferase IV; GPI-MT-IV; PIG-Z; Phosphatidylinositol-glycan biosynthesis class Z protein", "protein_names_refseq": "GPI alpha-1,2-mannosyltransferase 4; GPI mannosyltransferase 4; GPI mannosyltransferase IV; GPI-MT-IV; PIG-Z; phosphatidylinositol glycan, class Z; phosphatidylinositol-glycan biosynthesis class Z protein", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:239827); (R-MMU-162710)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Alpha-1,2-mannosyltransferase that catalyzes the transfer of the fourth mannose, via an alpha-1,2 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed M4C) and participates in the twelfth step of the glycosylphosphatidylinositol-anchor biosynthesis. The presence of a fourth mannose in GPI is facultative, suggesting that it only exists in some tissues., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 42, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q149K0", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0000030 mannosyltransferase activity;GO:0120565 dol-P-Man:Man(3)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BTP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVM9-1", "uniprot_id": "PH11A_MOUSE", "mass": 32673.0, "length": 293, "protein_name": "PHD finger protein 11A", "gene_name": "Phf11a", "organism": "Mouse", "refseq_name": "PHD finger protein 11A", "refseq_ac": "NP_766191", "gene_names_uniprotkb": "Phf11a; Phf11-4; Phf11l; Phf11", "gene_names_refseq": "4933417L10Rik; Phf11a; Phf11l; Phf11", "protein_names_uniprotkb": "PHD finger protein 11A; PHD finger protein 11-like; PHD finger protein 11", "protein_names_refseq": "PHD finger protein 11A; PHD finger protein 11", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); allergic disease (Disease Ontology:DOID:1205); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:219131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BVM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C115-1", "uniprot_id": "PKHH2_MOUSE", "mass": 167733.0, "length": 1491, "protein_name": "Pleckstrin homology domain-containing family H member 2", "gene_name": "Plekhh2", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family H member 2 isoform 1", "refseq_ac": "NP_808274", "gene_names_uniprotkb": "Plekhh2; Kiaa2028", "gene_names_refseq": "E030001K05; Plekhh2; mKIAA2028", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family H member 2", "protein_names_refseq": "pleckstrin homology domain-containing family H member 2 isoform 1; pleckstrin homology domain-containing family H member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:213556)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17251388;22832517;28528544;32782141;34428180", "class_list": "", "function": "In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia., [UniProtKB, PubMed]; Suggest a structural and functional role for Plekhh2 in the podocyte foot processes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ85;Q059P2;Q69Z29;Q8VDL8", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C115-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDG5-1", "uniprot_id": "PPCS_MOUSE", "mass": 33794.0, "length": 311, "protein_name": "Phosphopantothenate--cysteine ligase", "gene_name": "Ppcs", "organism": "Mouse", "refseq_name": "phosphopantothenate--cysteine ligase isoform 1", "refseq_ac": "NP_080770", "gene_names_uniprotkb": "Ppcs; Coab", "gene_names_refseq": "6330579B17Rik; Ppcs", "protein_names_uniprotkb": "Phosphopantothenate--cysteine ligase; 6.3.2.51; PPC synthetase; Phosphopantothenoylcysteine synthetase", "protein_names_refseq": "PPC synthetase; phosphopantothenate--cysteine ligase isoform 1; phosphopantothenate--cysteine ligase", "tax_id": 10090, "disease": "dilated cardiomyopathy 2C (Disease Ontology:DOID:0081159); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:106564); (R-MMU-196783)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "37507081", "class_list": "", "function": "Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVW0;Q9D376;Q9DA06", "ec_number_list": "6.3.2.51", "go_molecular_function": "GO:0004632 phosphopantothenate--cysteine ligase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006085 acetyl-CoA biosynthetic process;GO:0015937 coenzyme A biosynthetic process;GO:0003015 heart process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VDG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XU3-1", "uniprot_id": "PI42C_MOUSE", "mass": 47336.0, "length": 421, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "gene_name": "Pip4k2c", "organism": "Mouse", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "refseq_ac": "NP_473438", "gene_names_uniprotkb": "Pip4k2c; Pip5k2c", "gene_names_refseq": "Pip4k2c; Pip5k2c", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; 2.7.1.149; PI(5)P 4-kinase type II gamma; PIP4KII-gamma; Phosphatidylinositol 5-phosphate 4-kinase type II gamma", "protein_names_refseq": "PI(5)P 4-kinase type II gamma; PIP4KII-gamma; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; phosphatidylinositol-4-phosphate 5-kinase, type II, gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:117150); (R-MMU-1660499); (R-MMU-6811555); (R-MMU-6811558); (R-MMU-8847453)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "15018809;18753295;19757494;25428506;27313209;30084848;30779550;31599954;33300544;34026458;34203471;34428180;35820727;36691351;37828378", "class_list": "", "function": "Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c., [RefSeq, PubMed]; Our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain, [RefSeq, PubMed]; PI5P4Kgamma plays a role in the regulation of the immune system via mTORC1 signaling., [RefSeq, PubMed]; PIP4Kgamma may have a function in the regulation of vesicular transport in specialized kidney epithelial cells., [RefSeq, PubMed]; Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3., [UniProtKB, UniProtKB]; Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFU5;Q99K02", "ec_number_list": "2.7.1.149;2.7.12.2;5.2.1.8", "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010506 regulation of autophagy;GO:2000786 positive regulation of autophagosome assembly;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0061909 autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91XU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P27-1", "uniprot_id": "PG12B_MOUSE", "mass": 21736.0, "length": 195, "protein_name": "Group XIIB secretory phospholipase A2-like protein", "gene_name": "Pla2g12b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pla2g12b; Fksg71; Pla2g13", "gene_names_refseq": "", "protein_names_uniprotkb": "Group XIIB secretory phospholipase A2-like protein; GXIIB; GXIII sPLA2-like; Group XIII secretory phospholipase A2-like protein; sPLA2-GXIIB", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Not known; does not seem to have catalytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0034374 low-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0070328 triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99P27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D106-1", "uniprot_id": "PEPA5_MOUSE", "mass": 42824.0, "length": 387, "protein_name": "Pepsin A-5", "gene_name": "Pga5", "organism": "Mouse", "refseq_name": "pepsin A-5 precursor", "refseq_ac": "NP_067428", "gene_names_uniprotkb": "Pga5; Pepf", "gene_names_refseq": "1110035E17Rik; Pepf; Pga5", "protein_names_uniprotkb": "Pepsin A-5; 3.4.23.1; Pepsin F", "protein_names_refseq": "pepsin A-5 precursor; pepsin A-5; pepsin F; pepsinogen 5, group I; pepsinogen A5", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:58803)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11566730;25428506", "class_list": "", "function": "Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKE6", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAK9-1", "uniprot_id": "PHP14_MOUSE", "mass": 13997.0, "length": 124, "protein_name": "14 kDa phosphohistidine phosphatase", "gene_name": "Phpt1", "organism": "Mouse", "refseq_name": "14 kDa phosphohistidine phosphatase isoform 2", "refseq_ac": "NP_083569", "gene_names_uniprotkb": "Phpt1; Php14", "gene_names_refseq": "1700008C22Rik; PHP; Php14; Phpt1", "protein_names_uniprotkb": "14 kDa phosphohistidine phosphatase; 3.9.1.3; PHPT1; PHP; Phosphohistidine phosphatase 1; Protein histidine phosphatase", "protein_names_refseq": "14 kDa phosphohistidine phosphatase isoform 2; 14 kDa phosphohistidine phosphatase; protein histidine phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:75454)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29440278;37507081", "class_list": "", "function": "Exhibits phosphohistidine phosphatase activity., [UniProtKB, UniProtKB]; PHPT-1(-/-) mice exhibited neonatal hyperinsulinemic hypoglycemia due to impaired trafficking of KATP channels to the plasma membrane in pancreatic beta-cells in response to low glucose and leptin and resembled patients with congenital hyperinsulinism (CHI)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.9.1.3", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0019855 calcium channel inhibitor activity;GO:0101006 protein histidine phosphatase activity", "go_cellular_component": "GO:0061851 leading edge of lamellipodium;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:2000147 positive regulation of cell motility;GO:0097581 lamellipodium organization;GO:0050860 negative regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1Q7-1", "uniprot_id": "PLP2_MOUSE", "mass": 16608.0, "length": 152, "protein_name": "Proteolipid protein 2", "gene_name": "Plp2", "organism": "Mouse", "refseq_name": "proteolipid protein 2", "refseq_ac": "NP_062729", "gene_names_uniprotkb": "Plp2", "gene_names_refseq": "Plp2; mIMA4", "protein_names_uniprotkb": "Proteolipid protein 2", "protein_names_refseq": "proteolipid protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18824)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20043097;31219806", "class_list": "", "function": "May play a role in cell differentiation in the intestinal epithelium., [UniProtKB]; PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4I3", "ec_number_list": "", "go_molecular_function": "GO:0019956 chemokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R1Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z280-1", "uniprot_id": "PLD1_MOUSE", "mass": 123969.0, "length": 1074, "protein_name": "Phospholipase D1", "gene_name": "Pld1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pld1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase D1; 3.1.4.4; Choline phosphatase 1; PLD 1; Phosphatidylcholine-hydrolyzing phospholipase D1; mPLD1", "protein_names_refseq": "", "tax_id": 10090, "disease": "developmental cardiac valvular defect (Disease Ontology:DOID:0080633); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (R-MMU-1483166); (R-MMU-2029485); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013149); (R-MMU-9013408)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "21750661;25428506;34418053;37828378;9307024;9395408;9813240", "class_list": "", "function": "Function as phospholipase selectivefor phosphatidylcholine (PubMed:9395408). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (PubMed:9395408)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35911", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.14.19.17;5.2.1.-;2.3.1.-;3.1.16.1;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;3.6.5.2;2.7.1.153;2.7.1.137;3.1.2.-;7.6.2.-;1.1.1.-;3.6.4.-;2.7.11.13;2.7.11.39;3.2.1.20;3.1.4.4;2.7.10.1;3.4.24.-;2.3.1.78;2.7.10.2;3.1.4.-;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.7.11.25;2.3.1.51;2.1.2.1;7.1.1.2;3.1.4.39;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0006654 phosphatidic acid biosynthetic process;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXG9-1", "uniprot_id": "PHF19_MOUSE", "mass": 65236.0, "length": 578, "protein_name": "PHD finger protein 19", "gene_name": "Phf19", "organism": "Mouse", "refseq_name": "PHD finger protein 19 isoform a", "refseq_ac": "NP_082992", "gene_names_uniprotkb": "Phf19; Pcl3", "gene_names_refseq": "3110009G19Rik; 3321402G02Rik; Phf19", "protein_names_uniprotkb": "PHD finger protein 19; Polycomb-like protein 3", "protein_names_refseq": "PHD finger protein 19 isoform a; polycomb-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74016); (R-MMU-212300)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "21750661;21952136;22438827;23104054;23160351;23273982;25428506;25605945;30084848;31219806;32869745;33611744;34428180", "class_list": "", "function": "PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2., [RefSeq, PubMed]; Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:22438827, PubMed:23104054, PubMed:23160351, PubMed:23273982). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal (PubMed:22438827). Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity;GO:0140003 histone H3K36me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0048863 stem cell differentiation;GO:0019827 stem cell population maintenance;GO:0045814 negative regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CXG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61282-1", "uniprot_id": "PGCA_MOUSE", "mass": 221941.0, "length": 2132, "protein_name": "Aggrecan core protein", "gene_name": "Acan", "organism": "Mouse", "refseq_name": "aggrecan core protein isoform 2 precursor", "refseq_ac": "NP_031450", "gene_names_uniprotkb": "Acan; Agc1; Agc", "gene_names_refseq": "Acan; Agc1; Agc; CSPCP; Cspg1; b2b183Clo; cmd", "protein_names_uniprotkb": "Aggrecan core protein; CSPCP; Cartilage-specific proteoglycan core protein", "protein_names_refseq": "aggrecan 1; aggrecan core protein isoform 2 precursor; aggrecan core protein; cartilage-specific proteoglycan core protein", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); spondyloepiphyseal dysplasia Kimberley type (Disease Ontology:DOID:0112282); status epilepticus (Disease Ontology:DOID:1824); multiple sclerosis (Disease Ontology:DOID:2377); achondroplasia (Disease Ontology:DOID:4480); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:11595); (R-MMU-1474228); (R-MMU-2022854); (R-MMU-2022857); (R-MMU-3000178)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10400671;10633862;21750661;27270603;30899004;7524681;7806222;7920633", "class_list": "glycogene", "function": "This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage., [UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 4, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 153, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 9, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "E9QLS9;Q64021", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0030336 negative regulation of cell migration;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q61282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08969-1", "uniprot_id": "PHLA2_MOUSE", "mass": 16727.0, "length": 144, "protein_name": "Pleckstrin homology-like domain family A member 2", "gene_name": "Phlda2", "organism": "Mouse", "refseq_name": "pleckstrin homology-like domain family A member 2", "refseq_ac": "NP_033460", "gene_names_uniprotkb": "Phlda2; Ipl; Tssc3", "gene_names_refseq": "Ipl; Phlda2; Tssc3", "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 2; Imprinted in placenta and liver protein; Protein 50C15", "protein_names_refseq": "imprinted in placenta and liver protein; pleckstrin homology-like domain family A member 2; protein 50C15; tumor-suppressing subchromosomal transferable fragment 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22113)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10594239;12032310;12374806;15327781;21750661;33922969;38309267;9328465", "class_list": "", "function": "Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse. Publication Status: Online-Only, [RefSeq, PubMed]; PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression., [RefSeq, PubMed]; Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting., [RefSeq, PubMed]; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids., [UniProtKB, PubMed]; This gene is one of several genes in the imprinted gene domain on chromosome 7. Studies using knockout mice have shown that the product of this gene regulates placental growth. Transcripts from this gene are most abundant in placenta and yolk sac, and are almost entirely transcribed from the maternal allele. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0001890 placenta development;GO:0009887 animal organ morphogenesis;GO:0030334 regulation of cell migration;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESW8-1", "uniprot_id": "PGPI_MOUSE", "mass": 22934.0, "length": 209, "protein_name": "Pyroglutamyl-peptidase 1", "gene_name": "Pgpep1", "organism": "Mouse", "refseq_name": "pyroglutamyl-peptidase 1", "refseq_ac": "NP_075706", "gene_names_uniprotkb": "Pgpep1; Pgpi", "gene_names_refseq": "2810003H13Rik; Gm19458; PAP-I; PGP-I; PGPI; PGP; Pcp; Pgpep1", "protein_names_uniprotkb": "Pyroglutamyl-peptidase 1; 3.4.19.3; 5-oxoprolyl-peptidase; PAP-I; PGP-I; Pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase", "protein_names_refseq": "5-oxoprolyl-peptidase; putative pyroglutamyl-peptidase I; pyroglutamyl aminopeptidase I; pyroglutamyl-peptidase 1; pyrrolidone-carboxylate peptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66522)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12651114;21750661", "class_list": "", "function": "Cloning and sequencing of the mouse (AJ278829) pyroglutamyl-peptidase I, [RefSeq, PubMed]; Removes 5-oxoproline from various penultimate amino acid residues except L-proline., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016920 pyroglutamyl-peptidase activity;GO:0008233 peptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KGF7-1", "uniprot_id": "PLCB2_MOUSE", "mass": 134546.0, "length": 1181, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "gene_name": "Plcb2", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b", "refseq_ac": "NP_001277719", "gene_names_uniprotkb": "Plcb2", "gene_names_refseq": "B230205M18Rik; B230399N12; Plcb2", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 3.1.4.11; PLC-beta-2; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; PLC-beta-2; phosphoinositide phospholipase C-beta-2", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18796); (R-MMU-112043); (R-MMU-1855204); (R-MMU-399997); (R-MMU-4086398); (R-MMU-416476); (R-MMU-418217); (R-MMU-434316); (R-MMU-500657)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "21750661;22728827;25605945;34428180;35820727", "class_list": "", "function": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (PubMed:22728827)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2M4J1;Q3TER8;Q8BI81", "ec_number_list": "3.1.4.11;3.6.5.-", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005543 phospholipid binding;GO:0004629 phospholipase C activity;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0031680 G-protein beta/gamma-subunit complex;GO:0098992 neuronal dense core vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0016042 lipid catabolic process;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A3KGF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H619-1", "uniprot_id": "PHRF1_MOUSE", "mass": 184081.0, "length": 1682, "protein_name": "PHD and RING finger domain-containing protein 1", "gene_name": "Phrf1", "organism": "Mouse", "refseq_name": "PHD and RING finger domain-containing protein 1 isoform 1", "refseq_ac": "NP_001074587", "gene_names_uniprotkb": "Phrf1; Kiaa1542", "gene_names_refseq": "Phrf1", "protein_names_uniprotkb": "PHD and RING finger domain-containing protein 1", "protein_names_refseq": "PHD and RING finger domain-containing protein 1 isoform 1; PHD and RING finger domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:101471)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;30059200;31219806;35820727;36852467;37540725;40885482;40997131", "class_list": "", "function": "PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q505G1;Q6ZPN4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A6H619-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15327-1", "uniprot_id": "PMGE_MOUSE", "mass": 29978.0, "length": 259, "protein_name": "Bisphosphoglycerate mutase", "gene_name": "Bpgm", "organism": "Mouse", "refseq_name": "bisphosphoglycerate mutase isoform 1", "refseq_ac": "NP_031589", "gene_names_uniprotkb": "Bpgm", "gene_names_refseq": "Bpgm", "protein_names_uniprotkb": "Bisphosphoglycerate mutase; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; 5.4.2.11; 5.4.2.4; BPG-dependent PGAM; BPGM", "protein_names_refseq": "2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM; bisphosphoglycerate mutase isoform 1; bisphosphoglycerate mutase", "tax_id": 10090, "disease": "familial erythrocytosis 8 (Disease Ontology:DOID:0111630)", "pathway": " (mmu:12183); (R-MMU-70171)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19733906;21750661;26495903;2847721;32966787;34052998;37507081;37688507", "class_list": "", "function": "Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia., [RefSeq, PubMed]; Dysregulation of bisphosphoglycerate mutase during in vitro maturation of oocytes., [RefSeq, PubMed]; Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD model mice., [RefSeq, PubMed]; Placental expression of BPGM can influence maternal 2,3-bisphosphoglycerate (BPG) blood levels and supports a hypothesis under which BPG synthesized in the placenta may act on maternal haemoglobin to enhance delivery of oxygen to the developing fetus., [RefSeq, PubMed]; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q543Z6", "ec_number_list": "5.4.2.11;5.4.2.4", "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0060856 establishment of blood-brain barrier;GO:0006096 glycolytic process;GO:0033554 cellular response to stress;GO:0048821 erythrocyte development;GO:0042832 defense response to protozoan", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P15327-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1E8-1", "uniprot_id": "PLCE_MOUSE", "mass": 42202.0, "length": 365, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon", "gene_name": "Agpat5", "organism": "Mouse", "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon", "refseq_ac": "NP_081068", "gene_names_uniprotkb": "Agpat5; D8Ertd319e", "gene_names_refseq": "1110013A05Rik; Agpat5; D8Ertd319e", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-AGP acyltransferase 5; 1-AGPAT 5; 1-acylglycerol-3-phosphate O-acyltransferase 5; 2.3.1.51; LPAAT-epsilon; Lysophosphatidic acid acyltransferase epsilon", "protein_names_refseq": "1-AGP acyltransferase 5; 1-AGPAT 5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon); LPAAT-epsilon; lysophosphatidic acid acyltransferase epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:52123); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15367102;21750661;31219806;31599954;39927985", "class_list": "", "function": "Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (By similarity). Activity toward lysophosphatidylglycerol not detectable (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U702;Q8BG61;Q8CGN6", "ec_number_list": "2.3.1.51;2.3.1.15;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.-;2.3.1.121;2.3.1.n6;2.3.1.n7;3.1.1.4;3.1.1.3", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation;GO:0006639 acylglycerol metabolic process;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0036149 phosphatidylinositol acyl-chain remodeling;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D1E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VC4-1", "uniprot_id": "PLVAP_MOUSE", "mass": 49933.0, "length": 438, "protein_name": "Plasmalemma vesicle-associated protein", "gene_name": "Plvap", "organism": "Mouse", "refseq_name": "plasmalemma vesicle-associated protein", "refseq_ac": "NP_115774", "gene_names_uniprotkb": "Plvap; Pv1", "gene_names_refseq": "MECA32; Plvap; Pv1", "protein_names_uniprotkb": "Plasmalemma vesicle-associated protein; MECA-32 antigen; PV-1; Plasmalemma vesicle protein 1", "protein_names_refseq": "MECA-32 antigen; plasmalemma vesicle protein 1; plasmalemma vesicle-associated protein", "tax_id": 10090, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (mmu:84094)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11401446;16969073;21750661;22782339;34428180;37774966;7626790", "class_list": "", "function": "Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development., [UniProtKB, PubMed]; Expression analysis of plvap in mouse heart development, homeostasis and injury., [RefSeq, PubMed]; The PV-1 protein is negatively regulated in pulmonary endothelial cells by VEGF-R2 signaling., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q99JB1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0005901 caveola", "go_biological_process": "GO:0000165 MAPK cascade;GO:0032502 developmental process;GO:0043114 regulation of vascular permeability;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0002693 positive regulation of cellular extravasation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91VC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70579-1", "uniprot_id": "PM34_MOUSE", "mass": 34413.0, "length": 307, "protein_name": "Peroxisomal membrane protein PMP34", "gene_name": "Slc25a17", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein PMP34", "refseq_ac": "NP_035529", "gene_names_uniprotkb": "Slc25a17; Pmp34; Pmp35", "gene_names_refseq": "34kDa; 47kDa; PMP34; Pmp47; Slc25a17", "protein_names_uniprotkb": "Peroxisomal membrane protein PMP34; 34 kDa peroxisomal membrane protein; Solute carrier family 25 member 17", "protein_names_refseq": "34 kDa peroxisomal membrane protein; peroxisomal integral membrane protein 47; peroxisomal membrane protein PMP34; peroxisomal membrane protein, 34 kDa; solute carrier family 25, member 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:20524); (R-MMU-389599); (R-MMU-9603798)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;30084848;34428180;9874197", "class_list": "", "function": "Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0015297 antiporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0035350 FAD transmembrane transport;GO:0006635 fatty acid beta-oxidation;GO:0015908 fatty acid transport;GO:0015866 ADP transport;GO:0035349 coenzyme A transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70579-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26618-1", "uniprot_id": "PGFRA_MOUSE", "mass": 122683.0, "length": 1089, "protein_name": "Platelet-derived growth factor receptor alpha", "gene_name": "Pdgfra", "organism": "Mouse", "refseq_name": "platelet-derived growth factor receptor alpha isoform 1 precursor", "refseq_ac": "NP_001076785", "gene_names_uniprotkb": "Pdgfra", "gene_names_refseq": "CD140a; Pdgfr-2; Pdgfra", "protein_names_uniprotkb": "Platelet-derived growth factor receptor alpha; 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; PDGF-R-alpha; PDGFR-alpha; Platelet-derived growth factor alpha receptor", "protein_names_refseq": "Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); CD140 antigen-like family member A; PDGF alpha chain; PDGF-R-alpha; PDGFR-alpha; alpha-type platelet-derived growth factor receptor; platelet-derived growth factor receptor alpha isoform 1 precursor; platelet-derived growth factor receptor alpha", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); oligohydramnios (Disease Ontology:DOID:12215); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); prostate adenocarcinoma (Disease Ontology:DOID:2526); Leydig cell tumor (Disease Ontology:DOID:2696); carcinoma (Disease Ontology:DOID:305); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); craniopharyngioma (Disease Ontology:DOID:3840); brain stem glioma (Disease Ontology:DOID:4202); scimitar syndrome (Disease Ontology:DOID:4297); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); nephrolithiasis (Disease Ontology:DOID:585); chronic ulcer of skin (Disease Ontology:DOID:8549); myeloid sarcoma (Disease Ontology:DOID:8683); myeloid leukemia (Disease Ontology:DOID:8692); in situ carcinoma (Disease Ontology:DOID:8719); hypereosinophilic syndrome (Disease Ontology:DOID:999)", "pathway": " (mmu:18595); (R-MMU-1257604); (R-MMU-186763); (R-MMU-186797); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10837138;10903171;1321404;14514732;15207813;19030102;20110689;21183079;2174116;21750661;27894125;29237719;30986375;34428180;9226440", "class_list": "", "function": "Polyadenylation of a PDGFRalpha intron in resident stem cells attenuates muscle fibrosis, [RefSeq, PubMed]; This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]., [RefSeq]; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9420, "biomarker_type": "", "glycan_count": 4, "disease_count": 27, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ37;Q62046;Q7TSJ3;Q8C4N3", "ec_number_list": "2.7.12.2;2.7.10.1;3.2.1.31;2.7.12.1;2.7.1.153;2.7.1.137;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;3.6.5.2;2.7.11.17;3.2.2.6;3.1.3.48;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23;3.1.4.11;2.7.1.154", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001701 in utero embryonic development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P26618-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02257-1", "uniprot_id": "PLAK_MOUSE", "mass": 81801.0, "length": 745, "protein_name": "Junction plakoglobin", "gene_name": "Jup", "organism": "Mouse", "refseq_name": "junction plakoglobin", "refseq_ac": "NP_034723", "gene_names_uniprotkb": "Jup", "gene_names_refseq": "Ctnng; D930025P04Rik; Jup; PG", "protein_names_uniprotkb": "Junction plakoglobin; Desmoplakin III; Desmoplakin-3", "protein_names_refseq": "desmoplakin III; desmoplakin-3; gamma-catenin; junction plakoglobin", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); endometrial hyperplasia (Disease Ontology:DOID:0080365); Naxos disease (Disease Ontology:DOID:0080551); arrhythmogenic right ventricular dysplasia 12 (Disease Ontology:DOID:0110083); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); palmoplantar keratosis (Disease Ontology:DOID:3390); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603); neuropathy (Disease Ontology:DOID:870); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16480); (R-MMU-418990); (R-MMU-5218920); (R-MMU-6798695); (R-MMU-6805567); (R-MMU-6809371); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9762292); (R-MMU-9764561); (R-MMU-9766229); (R-MMU-9768727); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 17, "publication_count": 32, "publication_id_list": "1509266;16325582;16510446;19015309;19224205;20173027;21183079;22515648;25428506;25496840;27033150;28011936;29187734;30084848;30779550;32848054;33300544;34428180;34678516;34887587;35820727;36064721;37453647;37507081;37828378;38367915;38395410;39627609;40021952;40684658;40885482;7982500", "class_list": "", "function": "Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (PubMed:25496840)., [UniProtKB, PubMed, PubMed]; Plakoglobin regulates adipocyte differentiation independently of the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGD3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0045296 cadherin binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q02257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62066-1", "uniprot_id": "PHX2A_MOUSE", "mass": 29417.0, "length": 280, "protein_name": "Paired mesoderm homeobox protein 2A", "gene_name": "Phox2a", "organism": "Mouse", "refseq_name": "paired mesoderm homeobox protein 2A", "refseq_ac": "NP_032913", "gene_names_uniprotkb": "Phox2a; Arix; Phox2; Pmx2a; Pmx2", "gene_names_refseq": "Arix; Phox2a; Phox2; Pmx2a; Pmx2; Px2a", "protein_names_uniprotkb": "Paired mesoderm homeobox protein 2A; Aristaless homeobox protein homolog; PHOX2A homeodomain protein; Paired-like homeobox 2A", "protein_names_refseq": "PHOX2A homeodomain protein; aristaless homeobox gene homolog; aristaless homeobox protein homolog; paired mesoderm homeobox 2a; paired mesoderm homeobox protein 2A", "tax_id": 10090, "disease": "congenital fibrosis of the extraocular muscles 2 (Disease Ontology:DOID:0081016); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11859)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "32094113;37015885;7910552", "class_list": "", "function": "Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain., [RefSeq, PubMed]; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus (PubMed:32094113). Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0048486 parasympathetic nervous system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021623 oculomotor nerve formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UG2-1", "uniprot_id": "PLXA4_MOUSE", "mass": 212560.0, "length": 1893, "protein_name": "Plexin-A4", "gene_name": "Plxna4", "organism": "Mouse", "refseq_name": "plexin-A4 precursor", "refseq_ac": "NP_786926", "gene_names_uniprotkb": "Plxna4; Kiaa1550", "gene_names_refseq": "9330117B14; Plxa4; Plxna4; mKIAA1550", "protein_names_uniprotkb": "Plexin-A4", "protein_names_refseq": "plexin-A4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:243743); (R-MMU-399954); (R-MMU-399955); (R-MMU-399956)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12591607;16452087;18262512;18804103;30899004;33300544;35820727", "class_list": "", "function": "Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm., [UniProtKB, PubMed, PubMed]; Plexin-A4 was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1, plexin-A2 and plexin-A3), [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QN64;Q5DTW8;Q8BKK9", "ec_number_list": "", "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0150053 cerebellar climbing fiber to Purkinje cell synapse", "go_biological_process": "GO:0021615 glossopharyngeal nerve morphogenesis;GO:0007399 nervous system development;GO:0071526 semaphorin-plexin signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q80UG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLG0-1", "uniprot_id": "PHF20_MOUSE", "mass": 115280.0, "length": 1010, "protein_name": "PHD finger protein 20", "gene_name": "Phf20", "organism": "Mouse", "refseq_name": "PHD finger protein 20", "refseq_ac": "NP_766262", "gene_names_uniprotkb": "Phf20; Hca58", "gene_names_refseq": "6820402O20Rik; Phf20", "protein_names_uniprotkb": "PHD finger protein 20; Hepatocellular carcinoma-associated antigen 58 homolog", "protein_names_refseq": "PHD finger protein 20; hepatocellular carcinoma-associated antigen 58 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:228829); (R-MMU-3214847); (R-MMU-6804757); (R-MMU-6804759); (R-MMU-69541); (R-MMU-9772755)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22072714;25428506;25605945;30084848;31219806;32555448;34428180", "class_list": "", "function": "Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage (By similarity). Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues., [UniProtKB, PubMed]; PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF target genes, [RefSeq, PubMed]; Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMA2;Q8BYR4;Q921N1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0071339 MLL1 complex;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BLG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHP6-1", "uniprot_id": "PHC3_MOUSE", "mass": 105353.0, "length": 981, "protein_name": "Polyhomeotic-like protein 3", "gene_name": "Phc3", "organism": "Mouse", "refseq_name": "polyhomeotic-like protein 3 isoform 1", "refseq_ac": "NP_001159426", "gene_names_uniprotkb": "Phc3", "gene_names_refseq": "E030046K01Rik; Edr3; Hph3; Phc3", "protein_names_uniprotkb": "Polyhomeotic-like protein 3", "protein_names_refseq": "polyhomeotic-like 3; polyhomeotic-like protein 3 isoform 1; polyhomeotic-like protein 3", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:241915); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724); (R-MMU-8953750)", "pathway_count": 8, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12384788;17242355;19458039;21183079;21606357;21750661;22645316;30059200;32782141;32848054;34428180;36852467;40021952;40885482;40997131", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2RTJ9;Q3TLV5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8CHP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0G7-1", "uniprot_id": "PHGR1_MOUSE", "mass": 8681.0, "length": 91, "protein_name": "Proline, histidine and glycine-rich protein 1", "gene_name": "Phgr1", "organism": "Mouse", "refseq_name": "proline, histidine and glycine-rich protein 1", "refseq_ac": "NP_001139116", "gene_names_uniprotkb": "Phgr1", "gene_names_refseq": "1810007E14Rik; Phgr1", "protein_names_uniprotkb": "Proline, histidine and glycine-rich protein 1", "protein_names_refseq": "proline, histidine and glycine-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:53906)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR74", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K0G7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2W6-1", "uniprot_id": "PHF13_MOUSE", "mass": 33424.0, "length": 296, "protein_name": "PHD finger protein 13", "gene_name": "Phf13", "organism": "Mouse", "refseq_name": "PHD finger protein 13", "refseq_ac": "NP_766293", "gene_names_uniprotkb": "Phf13", "gene_names_refseq": "Phf13; Phf5; SPOC1", "protein_names_uniprotkb": "PHD finger protein 13", "protein_names_refseq": "PHD finger protein 13; PHD zinc finger protein PHF5", "tax_id": 10090, "disease": "", "pathway": " (mmu:230936)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21852425;24794298", "class_list": "", "function": "Indispensable for stem cell differentiation in the testis and for sustained spermatogenesis, [RefSeq, PubMed]; Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation (By similarity). Essential for testicular stem-cell differentiation and sustained spermatogenesis (PubMed:21852425)., [UniProtKB, PubMed, UniProtKB]; Rods fail to robustly accumulate active ATM at DNA double-strand breakd, exhibit low KAP1 levels, and display high levels of SPOC1, a factor suppressing KAP1 phosphorylation. This results in dramatically reduced KAP1 phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0062072 histone H3K9me2/3 reader activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0007076 mitotic chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K2W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3R3-1", "uniprot_id": "PLCD4_MOUSE", "mass": 92694.0, "length": 807, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "gene_name": "Plcd4", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1", "refseq_ac": "NP_001074925", "gene_names_uniprotkb": "Plcd4; Plcd", "gene_names_refseq": "4921507K24Rik; Plcd4", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; 3.1.4.11; PLC-delta-4; Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; PLC-delta-4; phosphoinositide phospholipase C-delta-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:18802); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10601847;11340203;12695499;16272139;16998201;21750661;21974932;27062607", "class_list": "", "function": "Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation., [UniProtKB, PubMed, PubMed, PubMed]; These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs., [RefSeq, PubMed]; We identify PLCdelta4 as a PLC isoform important in the regulation of TRPM8 both at the cellular level and in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USN9;Q6NZF7;Q8CAB1;Q9CUC1", "ec_number_list": "3.1.4.11;2.3.1.-;3.1.16.1", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0016042 lipid catabolic process;GO:0007340 acrosome reaction;GO:0007264 small GTPase-mediated signal transduction;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K3R3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R526-1", "uniprot_id": "PK1L1_MOUSE", "mass": 290844.0, "length": 2615, "protein_name": "Polycystin-1-like protein 1", "gene_name": "Pkd1l1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pkd1l1; Rks", "gene_names_refseq": "", "protein_names_uniprotkb": "Polycystin-1-like protein 1; PC1-like 1 protein; Polycystic kidney disease protein 1-like 1; Polycystin-1L1; Protein rikishi", "protein_names_refseq": "", "tax_id": 10090, "disease": "visceral heterotaxy 8 (Disease Ontology:DOID:0051022)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "11863367;20080492;21307093;21750661;24336289;25605945", "class_list": "", "function": "Component of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription. The PKD1L1:PKD2L1 channel complex is mechanosensitive only at high pressures and is highly temperature sensitive. Also involved in left/right axis specification downstream of nodal flow by forming a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. May function as a G-protein-coupled receptor., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 9, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "F6VYK1;J3QMZ2", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005929 cilium;GO:0016020 membrane;GO:0097730 non-motile cilium;GO:0034704 calcium channel complex;GO:0060170 ciliary membrane", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0003127 detection of nodal flow;GO:0007507 heart development;GO:0007368 determination of left/right symmetry;GO:0070986 left/right axis specification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R526-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X88-1", "uniprot_id": "PMGT1_MOUSE", "mass": 75110.0, "length": 660, "protein_name": "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "gene_name": "Pomgnt1", "organism": "Mouse", "refseq_name": "protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 3", "refseq_ac": "NP_001277587", "gene_names_uniprotkb": "Pomgnt1", "gene_names_refseq": "0610016I07Rik; 4930467B06Rik; Pomgnt1", "protein_names_uniprotkb": "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; 2.4.1.-; POMGnT1", "protein_names_refseq": "O-mannosyl N-acetylglucosaminyltransferase; protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 3; protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); retinitis pigmentosa 76 (Disease Ontology:DOID:0061103); autosomal recessive limb-girdle muscular dystrophy type 2O (Disease Ontology:DOID:0110292); congenital muscular dystrophy-dystroglycanopathy type A3 (Disease Ontology:DOID:0111236); muscular dystrophy-dystroglycanopathy type B3 (Disease Ontology:DOID:0112378); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:68273); (R-MMU-8932504); (R-MMU-8932506); (R-MMU-9939291)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12670716;16458488;17034757;26908613;34428180;35320023;36210013", "class_list": "glycogene;glycosyltransferase", "function": "Decreased expression of protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase 1 contributes to Alzheimer's disease-like pathologies., [RefSeq, PubMed]; From these findings, we propose that fukutin forms a complex with POMGnT1 and may modulate its enzymatic activity., [RefSeq, PubMed]; Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose., [UniProtKB, UniProtKB]; The present study provides the first genetic animal model to further dissect the roles of POMGnT1 in MEB disease., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A8F8;Q9D2H7;Q9D5D3;Q9DCN3", "ec_number_list": "2.4.2.-;2.7.8.-;2.4.2.61;2.4.1.-", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0030246 carbohydrate binding;GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0042552 myelination;GO:0007420 brain development", "synthesized_glycan_count": 198, "hit_score": 0.8, "record_id": "Q91X88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAG9-1", "uniprot_id": "PHF7_MOUSE", "mass": 35381.0, "length": 307, "protein_name": "E3 ubiquitin-protein ligase PHF7", "gene_name": "Phf7", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase PHF7 isoform 1", "refseq_ac": "NP_082225", "gene_names_uniprotkb": "Phf7", "gene_names_refseq": "1700006H01Rik; 1700010P14Rik; Phf7", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PHF7; 2.3.2.27; PHD finger protein 7; Testis development protein NYD-SP6", "protein_names_refseq": "E3 ubiquitin-protein ligase PHF7 isoform 1; E3 ubiquitin-protein ligase PHF7; testis development protein NYD-SP6", "tax_id": 10090, "disease": "", "pathway": " (mmu:71838)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11829468;21750661;25428506;27752147;31189663;32726616;33941892;37993255;38430697", "class_list": "", "function": "E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (PubMed:32726616). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (PubMed:32726616). Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange (PubMed:32726616). Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis (PubMed:38430697). Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters (PubMed:33941892). Ubiquitinates histone H4 (By similarity). Ubiquitinates histone H2A and H3 as part of the nucleosome core particle (PubMed:37993255)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; PHF7 is a novel E3 ligase that can specifically ubiquitylate H2A through binding H3K4me3/me2 prior to histone-to-protamine exchange. Erratum:[Development. 2020 Apr 27;147(8):dev191445. doi: 10.1242/dev.191445. PMID: 32341030] Publication Status: Online-Only, [RefSeq, PubMed]; Phf7 has impacts on the body growth and bone remodeling by regulating testicular hormones in male mice., [RefSeq, PubMed]; The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming., [RefSeq, PubMed]; Validated as novel and reliable, tissue-specific reference gene in qRT-PCR studies of postnatal mammary gland development Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG81", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140851 histone H3K14 ubiquitin ligase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0090291 negative regulation of osteoclast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DAG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCE5-1", "uniprot_id": "PK1IP_MOUSE", "mass": 42116.0, "length": 382, "protein_name": "p21-activated protein kinase-interacting protein 1", "gene_name": "Pak1ip1", "organism": "Mouse", "refseq_name": "p21-activated protein kinase-interacting protein 1", "refseq_ac": "NP_080826", "gene_names_uniprotkb": "Pak1ip1", "gene_names_refseq": "5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1; Pak1ip1", "protein_names_uniprotkb": "p21-activated protein kinase-interacting protein 1; PAK1-interacting protein 1; Putative PAK inhibitor Skb15", "protein_names_refseq": "glycerophosphodiester phosphodiesterase domain containing 1; p21-activated protein kinase-interacting protein 1; putative PAK inhibitor Skb15", "tax_id": 10090, "disease": "", "pathway": " (mmu:68083)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11389855;17429073;23935987;34428180", "class_list": "", "function": "A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly., [UniProtKB, UniProtKB]; Results suggest that the PAK-PIX-GIT1 complex is critical for Erk-dependent myosin phosphorylation and vascular permeability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBK7;Q80UT4;Q8C5N6;Q923K2;Q9D3E9", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0008283 cell population proliferation;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0060021 roof of mouth development;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV95-1", "uniprot_id": "PHLA3_MOUSE", "mass": 13719.0, "length": 125, "protein_name": "Pleckstrin homology-like domain family A member 3", "gene_name": "Phlda3", "organism": "Mouse", "refseq_name": "pleckstrin homology-like domain family A member 3", "refseq_ac": "NP_038778", "gene_names_uniprotkb": "Phlda3; Tih1", "gene_names_refseq": "Phlda3; Tih1", "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1", "protein_names_refseq": "TDAG/lpl homolog 1; TDAG51/Ipl homolog 1; pleckstrin homology-like domain family A member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:27280)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10594239;12032310;12374806;24912192;34428180;36965748;37558703", "class_list": "", "function": "Characterizing the role of Phlda3 in the development of acute toxicity and malignant transformation of hematopoietic cells induced by total-body irradiation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia., [RefSeq, PubMed]; Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs., [RefSeq, PubMed]; PHLDA3 activated by BARX2 transcription, suppresses the malignant development of esophageal squamous cell carcinoma by downregulating PI3K/AKT levels., [RefSeq, PubMed]; p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WV95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVQ0-1", "uniprot_id": "PMFBP_MOUSE", "mass": 119401.0, "length": 1022, "protein_name": "Polyamine-modulated factor 1-binding protein 1", "gene_name": "Pmfbp1", "organism": "Mouse", "refseq_name": "polyamine-modulated factor 1-binding protein 1", "refseq_ac": "NP_064322", "gene_names_uniprotkb": "Pmfbp1; Stap", "gene_names_refseq": "1700016D22Rik; F77; Pmfbp1; Stap", "protein_names_uniprotkb": "Polyamine-modulated factor 1-binding protein 1; PMF-1-binding protein; Sperm tail-associated protein", "protein_names_refseq": "PMF-1-binding protein; polyamine-modulated factor 1-binding protein 1; sperm tail-associated protein", "tax_id": 10090, "disease": "spermatogenic failure 31 (Disease Ontology:DOID:0111922); male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:56523)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11468771;30032984;30298696;34389728;37423931", "class_list": "", "function": "Loss of PMFBP1 Disturbs Mouse Spermatogenesis by Downregulating HDAC3 Expression., [RefSeq, PubMed]; Mutations in PMFBP1 are an important cause of infertility in men with acephalic spermatozoa syndrome., [RefSeq, PubMed]; Our data indicate that PMFBP1 is necessary for sperm morphology in both humans and mice, and that biallelic truncating mutations in PMFBP1 cause acephalic spermatozoa, [RefSeq, PubMed]; Required for normal spermatogenesis (PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton., [UniProtKB, PubMed, PubMed, PubMed]; The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head;GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0032880 regulation of protein localization;GO:0008104 intracellular protein localization;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WVQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1B8-1", "uniprot_id": "PHF1_MOUSE", "mass": 61140.0, "length": 559, "protein_name": "PHD finger protein 1", "gene_name": "Phf1", "organism": "Mouse", "refseq_name": "PHD finger protein 1 isoform 1", "refseq_ac": "NP_033369", "gene_names_uniprotkb": "Phf1; Plc1; Tctex-3; Tctex3", "gene_names_refseq": "D17Ertd455e; Pcl1; Phf1; Phf2; Tctex3", "protein_names_uniprotkb": "PHD finger protein 1; Polycomb-like protein 1; Protein PHF1; T-complex testis-expressed 3; mPCl1", "protein_names_refseq": "PHD finger protein 1 isoform 1; polycomb-like protein 1; t-complex testis-expressed 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:21652); (R-MMU-212300)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10545244;11559747;18086877;21750661;23104054;31219806;32869745;34428180;9799836", "class_list": "", "function": "Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53., [UniProtKB, PubMed]; Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the polycomb-like protein family, which is a component of polycomb repressive complex-2. This complex represses gene expression by catalyzing the trimethylation of histone H3 lysine 27 and is required for the regulation of developmental genes including homeotic genes. The gene is expressed primarily in testis tissue. Small interfering RNA-mediated knockdown in cultured cell lines results in changes in homeotic gene expression coincident with alterations in promoter methylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54808", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:1990226 histone methyltransferase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045814 negative regulation of gene expression, epigenetic;GO:0140861 DNA repair-dependent chromatin remodeling;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z1B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N95-1", "uniprot_id": "RM03_MOUSE", "mass": 39110.0, "length": 348, "protein_name": "Large ribosomal subunit protein uL3m", "gene_name": "Mrpl3", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL3m isoform 1", "refseq_ac": "NP_444389", "gene_names_uniprotkb": "Mrpl3", "gene_names_refseq": "2010320L16Rik; 5930422H18Rik; L3mt; Mrpl3; dcr", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3m; 39S ribosomal protein L3, mitochondrial; L3mt; MRP-L3", "protein_names_refseq": "39S ribosomal protein L3, mitochondrial; large ribosomal subunit protein uL3m isoform 1; large ribosomal subunit protein uL3m", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 9 (Disease Ontology:DOID:0111472)", "pathway": " (mmu:94062); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11279069;21750661;32341096;34428180", "class_list": "", "function": "Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces Adult-Onset Neurodegeneration with Memory Impairment in the Mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF66;Q9CVE4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99N95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35979-1", "uniprot_id": "RL12_MOUSE", "mass": 17805.0, "length": 165, "protein_name": "Large ribosomal subunit protein uL11", "gene_name": "Rpl12", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL11", "refseq_ac": "NP_033102", "gene_names_uniprotkb": "Rpl12", "gene_names_refseq": "E430018F03; Rpl12", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11; 60S ribosomal protein L12", "protein_names_refseq": "60S ribosomal protein L12; large ribosomal subunit protein uL11", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:269261); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22645316;34428180;35984892;36210013;36288343;37453647;37507081;39627609;39927985;8359697", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQK4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P35979-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7N6-1", "uniprot_id": "RM30_MOUSE", "mass": 18342.0, "length": 160, "protein_name": "Large ribosomal subunit protein uL30m", "gene_name": "Mrpl30", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL30m precursor", "refseq_ac": "NP_081374", "gene_names_uniprotkb": "Mrpl30", "gene_names_refseq": "2310001L22Rik; L30mt; MRP-L28; MRP-L30; Mrpl30; Rpml28", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30m; 39S ribosomal protein L30, mitochondrial; L30mt; MRP-L30", "protein_names_refseq": "39S ribosomal protein L30, mitochondrial; large ribosomal subunit protein uL30m precursor; large ribosomal subunit protein uL30m", "tax_id": 10090, "disease": "", "pathway": " (mmu:107734); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KJ7", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D7N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJC6-1", "uniprot_id": "RIPL1_MOUSE", "mass": 47323.0, "length": 406, "protein_name": "RILP-like protein 1", "gene_name": "Rilpl1", "organism": "Mouse", "refseq_name": "RILP-like protein 1 isoform 2", "refseq_ac": "NP_067405", "gene_names_uniprotkb": "Rilpl1; MNCb-2440", "gene_names_refseq": "2900002H16Rik; 6330559I19Rik; GOSPEL; Rilpl1", "protein_names_uniprotkb": "RILP-like protein 1; Rab-interacting lysosomal-like protein 1", "protein_names_refseq": "RILP-like protein 1 isoform 2; RILP-like protein 1; rab-interacting lysosomal-like protein 1", "tax_id": 10090, "disease": "oculopharyngodistal myopathy 4 (Disease Ontology:DOID:0081300)", "pathway": " (mmu:75695)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19607794;21183079;21750661;23264467;34428180", "class_list": "", "function": "In intact mice, virally delivered GOSPEL selectively diminishes NMDA neurotoxicity. Thus, GOSPEL may physiologically regulate the viability of neurons and other cells. Erratum:[Neuron. 2009 Sep 10;63(5):709. Aggrawal, Nishant [corrected to Agrawal, Nishant]], [RefSeq, PubMed]; Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Plays a role in the regulation of cell shape and polarity (PubMed:23264467). Plays a role in cellular protein transport, including protein transport away from primary cilia (PubMed:23264467). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content by promoting protein removal from the primary cilium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WV8", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007263 nitric oxide mediated signal transduction;GO:0060271 cilium assembly;GO:0003382 epithelial cell morphogenesis;GO:1903445 protein transport from ciliary membrane to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51410-1", "uniprot_id": "RL9_MOUSE", "mass": 21881.0, "length": 192, "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "Rpl9", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL6", "refseq_ac": "NP_035422", "gene_names_uniprotkb": "Rpl9", "gene_names_refseq": "Rpl9", "protein_names_uniprotkb": "Large ribosomal subunit protein uL6; 60S ribosomal protein L9", "protein_names_refseq": "60S ribosomal protein L9; large ribosomal subunit protein uL6", "tax_id": 10090, "disease": "", "pathway": " (mmu:20005); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 17, "publication_id_list": "21750661;23135726;23806337;25428506;25605945;30084848;31599954;33649389;34428180;35059969;35820727;35984892;36210013;36517592;37453647;39627609;7600302", "class_list": "glycogene", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]; Identification of ribosomal protein L9 as a novel regulator of proinflammatory damage-associated molecular pattern molecules., [RefSeq, PubMed]; These data support the hypothesis that efficient mouse mammary tumor virus particle assembly is dependent upon the interaction of Gag and L9 in the nucleoli of infected cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK58", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P51410-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFX1-1", "uniprot_id": "RN187_MOUSE", "mass": 26313.0, "length": 236, "protein_name": "E3 ubiquitin-protein ligase RNF187", "gene_name": "Rnf187", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF187", "refseq_ac": "NP_071868", "gene_names_uniprotkb": "Rnf187", "gene_names_refseq": "2410016F01Rik; RACO-1; Rnf187", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF187; 2.3.2.27; RACO-1; RING domain AP1 coactivator 1; RING finger protein 187; RING-type E3 ubiquitin transferase RNF187", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF187; RING domain AP1 coactivator 1; RING-type E3 ubiquitin transferase RNF187; protein RNF187", "tax_id": 10090, "disease": "", "pathway": " (mmu:108660)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10679242;20852630;21750661;37738023", "class_list": "", "function": "E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA64;Q8C2B0;Q8CAS0;Q9JMF6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BFX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47911-1", "uniprot_id": "RL6_MOUSE", "mass": 33510.0, "length": 296, "protein_name": "Large ribosomal subunit protein eL6", "gene_name": "Rpl6", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL6", "refseq_ac": "NP_035420", "gene_names_uniprotkb": "Rpl6", "gene_names_refseq": "Rpl6; Taxreb107", "protein_names_uniprotkb": "Large ribosomal subunit protein eL6; 60S ribosomal protein L6; TAX-responsive enhancer element-binding protein 107; TAXREB107", "protein_names_refseq": "60S ribosomal protein L6; TAX-responsive enhancer element-binding protein 107; large ribosomal subunit protein eL6", "tax_id": 10090, "disease": "", "pathway": " (mmu:19988); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 23, "publication_id_list": "11823430;20485683;21750661;23806337;25428506;25605945;26495903;26740625;30084848;31219806;31599954;33300544;33725478;34428180;35820727;36210013;36288343;36517592;37453647;37507081;37828378;39627609;7537974", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5I2;Q925C3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P47911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R367-1", "uniprot_id": "RERG_MOUSE", "mass": 22580.0, "length": 199, "protein_name": "Ras-related and estrogen-regulated growth inhibitor", "gene_name": "Rerg", "organism": "Mouse", "refseq_name": "ras-related and estrogen-regulated growth inhibitor isoform a", "refseq_ac": "NP_001157684", "gene_names_uniprotkb": "Rerg", "gene_names_refseq": "Rerg", "protein_names_uniprotkb": "Ras-related and estrogen-regulated growth inhibitor; 3.6.5.2", "protein_names_refseq": "ras-related and estrogen-regulated growth inhibitor isoform a; ras-related and estrogen-regulated growth inhibitor", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:232441)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0007265 Ras protein signal transduction;GO:0030308 negative regulation of cell growth;GO:0009725 response to hormone;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R367-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFY0-1", "uniprot_id": "RRP36_MOUSE", "mass": 28589.0, "length": 244, "protein_name": "Ribosomal RNA processing protein 36 homolog", "gene_name": "Rrp36", "organism": "Mouse", "refseq_name": "ribosomal RNA processing protein 36 homolog isoform 1", "refseq_ac": "NP_659106", "gene_names_uniprotkb": "Rrp36", "gene_names_refseq": "Rrp36", "protein_names_uniprotkb": "Ribosomal RNA processing protein 36 homolog", "protein_names_refseq": "RNA processing factor; ribosomal RNA processing 36 homolog; ribosomal RNA processing protein 36 homolog isoform 1; ribosomal RNA processing protein 36 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:224823); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "18250455;21183079;21750661;21952136;25428506;25428507;25605945;30084848;30779550;31219806;33649389;34428180", "class_list": "", "function": "Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X71", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UFY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z275-1", "uniprot_id": "RLBP1_MOUSE", "mass": 36408.0, "length": 317, "protein_name": "Retinaldehyde-binding protein 1", "gene_name": "Rlbp1", "organism": "Mouse", "refseq_name": "retinaldehyde-binding protein 1", "refseq_ac": "NP_001166954", "gene_names_uniprotkb": "Rlbp1; Cralbp", "gene_names_refseq": "3110056M11Rik; CRALBP; Rlbp1", "protein_names_uniprotkb": "Retinaldehyde-binding protein 1; Cellular retinaldehyde-binding protein", "protein_names_refseq": "cellular retinaldehyde-binding protein; retinaldehyde-binding protein 1", "tax_id": 10090, "disease": "Bothnia retinal dystrophy (Disease Ontology:DOID:0050683); Newfoundland cone-rod dystrophy (Disease Ontology:DOID:0111015); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (mmu:19771); (R-MMU-2187335); (R-MMU-2453902)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;23143414;38676924;9736766", "class_list": "", "function": "Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors., [RefSeq, PubMed]; Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0019841 retinol binding;GO:0005502 11-cis retinal binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0044297 cell body", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z275-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VH31-1", "uniprot_id": "RFPLA_MOUSE", "mass": 32358.0, "length": 287, "protein_name": "Ret finger protein-like 4A", "gene_name": "Rfpl4a; Rfpl4", "organism": "Mouse", "refseq_name": "ret finger protein-like 4A", "refseq_ac": "NP_001138485", "gene_names_uniprotkb": "Rfpl4a; Rfpl4; Rfpl4", "gene_names_refseq": "D7Ertd486e; Rfpl4a; Rfpl4", "protein_names_uniprotkb": "Ret finger protein-like 4A", "protein_names_refseq": "ret finger protein-like 4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:192658)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11850190;12525704;21750661", "class_list": "", "function": "RFPL4 functions as an E3 ubiquitin protein ligase to regulate protein degradation and meiosis in mouse oocytes., [RefSeq, PubMed]; The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IS67", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VH31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35980-1", "uniprot_id": "RL18_MOUSE", "mass": 21645.0, "length": 188, "protein_name": "Large ribosomal subunit protein eL18", "gene_name": "Rpl18", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL18 isoform 1", "refseq_ac": "NP_033103", "gene_names_uniprotkb": "Rpl18", "gene_names_refseq": "L18; Rpl18a; Rpl18", "protein_names_uniprotkb": "Large ribosomal subunit protein eL18; 60S ribosomal protein L18", "protein_names_refseq": "60S ribosomal protein L18; large ribosomal subunit protein eL18 isoform 1; large ribosomal subunit protein eL18", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 18 (Disease Ontology:DOID:0111896); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:19899); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 19, "publication_id_list": "18250455;20173027;21183079;21750661;25428506;25428507;25605945;30084848;30779550;31219806;32923109;34428180;35984892;36288343;36517592;37453647;37507081;39627609;8359697", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQF1;Q9D987", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P35980-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VI7-1", "uniprot_id": "RINI_MOUSE", "mass": 49816.0, "length": 456, "protein_name": "Ribonuclease inhibitor", "gene_name": "Rnh1", "organism": "Mouse", "refseq_name": "ribonuclease inhibitor isoform a", "refseq_ac": "NP_001165571", "gene_names_uniprotkb": "Rnh1; Rnh", "gene_names_refseq": "RNH; Rnh1", "protein_names_uniprotkb": "Ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1", "protein_names_refseq": "ribonuclease inhibitor isoform a; ribonuclease inhibitor", "tax_id": 10090, "disease": "", "pathway": " (mmu:107702)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "20307645;21750661;24941155;25153642;26495903;29187734;29408805;32152506;34428180;37453647;37507081;38783241;39927985", "class_list": "", "function": "Mouse angiogenin inhibitor 1 interacts with hylA of Streptococcus suis., [RefSeq, PubMed]; New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; RNH1 binds to the 40S subunit of ribosomes and facilitates polysome formation on Gata1 mRNA to confer transcript-specific translation., [RefSeq, PubMed]; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; X-ray crystallographic analysis of RNH1 from mouse, bovine and chicken binding to RNase reveals two residues that appear to contribute to the differential binding affinity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q924P4", "ec_number_list": "", "go_molecular_function": "GO:0008428 ribonuclease inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032055 negative regulation of translation in response to stress;GO:0016477 cell migration;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0045765 regulation of angiogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91VI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48377-1", "uniprot_id": "RFX1_MOUSE", "mass": 103707.0, "length": 963, "protein_name": "MHC class II regulatory factor RFX1", "gene_name": "Rfx1", "organism": "Mouse", "refseq_name": "MHC class II regulatory factor RFX1", "refseq_ac": "NP_033081", "gene_names_uniprotkb": "Rfx1", "gene_names_refseq": "Rfx1", "protein_names_uniprotkb": "MHC class II regulatory factor RFX1; Regulatory factor X 1; Transcription factor RFX1", "protein_names_refseq": "MHC class II regulatory factor RFX1; regulatory factor X 1; transcription factor RFX1; vregulatory factor X, 1 (influences HLA class II expression)", "tax_id": 10090, "disease": "", "pathway": " (mmu:19724)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15229132;21750661;30084848;32725242;32782141;32848054;34678516;35822049;36852467;37507081;37733446;38402833;40885482;40997131;8289803", "class_list": "", "function": "Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis., [RefSeq, PubMed]; RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression., [RefSeq, PubMed]; Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGH8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P48377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07742-1", "uniprot_id": "RIR1_MOUSE", "mass": 90210.0, "length": 792, "protein_name": "Ribonucleoside-diphosphate reductase large subunit", "gene_name": "Rrm1", "organism": "Mouse", "refseq_name": "ribonucleoside-diphosphate reductase large subunit", "refseq_ac": "NP_033129", "gene_names_uniprotkb": "Rrm1", "gene_names_refseq": "RnrM1; Rrm1", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase large subunit; 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit", "protein_names_refseq": "ribonucleoside-diphosphate reductase large subunit; ribonucleoside-diphosphate reductase subunit M1; ribonucleotide reductase large subunit", "tax_id": 10090, "disease": "chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:20133); (R-MMU-499943)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10967031;19176520;19224205;20173027;21540332;21750661;22645316;22872234;24788674;25153642;25428506;25428507;25605945;2581962;28135057;28315936;28528544;30084848;30779550;31616917;32152506;33649389;34203471;34428180;35820727;35984892;36210013;37828378;9285407", "class_list": "", "function": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91YM8", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0097718 disordered domain specific binding;GO:0017076 purine nucleotide binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006281 DNA repair;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051290 protein heterotetramerization;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P07742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19253-1", "uniprot_id": "RL13A_MOUSE", "mass": 23464.0, "length": 203, "protein_name": "Large ribosomal subunit protein uL13", "gene_name": "Rpl13a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL13", "refseq_ac": "NP_033464", "gene_names_uniprotkb": "Rpl13a; P198; Tstap198-7", "gene_names_refseq": "1810026N22Rik; Rpl13a; Tstap198-7; tum-antigen", "protein_names_uniprotkb": "Large ribosomal subunit protein uL13; 60S ribosomal protein L13a; Transplantation antigen P198; Tum-P198 antigen", "protein_names_refseq": "60S ribosomal protein L13a; large ribosomal subunit protein uL13; tissue specific transplantation antigen P198-7; transplantation antigen P198; tum-P198 antigen; tum-transplantation antigen P198", "tax_id": 10090, "disease": "", "pathway": " (mmu:22121); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 15, "publication_id_list": "1694221;21750661;23071094;24463520;25605945;30779550;31219806;34428180;35820727;36288343;36517592;37453647;37902531;39627609;8188249", "class_list": "glycogene", "function": "Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:36517592). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Involved in methylation of rRNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Loss of function of ribosomal protein L13a blocks blastocyst formation and reveals a potential nuclear role in gene expression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0032496 response to lipopolysaccharide;GO:0017148 negative regulation of translation;GO:0042592 homeostatic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P19253-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZWV3-1", "uniprot_id": "RL10_MOUSE", "mass": 24604.0, "length": 214, "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "Rpl10", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL16", "refseq_ac": "NP_443067", "gene_names_uniprotkb": "Rpl10; Qm", "gene_names_refseq": "D0HXS648; DXHXS648E; DXHXS648; QM16; QM; Rpl10", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16; 60S ribosomal protein L10; Protein QM homolog; Ribosomal protein L10", "protein_names_refseq": "24.6 kDa protein; 24.6kDa protein; 60S ribosomal protein L10; large ribosomal subunit protein uL16; protein QM homolog; ribosomal protein 10", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); syndromic X-linked mental retardation 35 (Disease Ontology:DOID:0080241); autistic disorder (Disease Ontology:DOID:12849); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (mmu:110954); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 14, "publication_id_list": "21750661;22645316;22872234;24463520;26740625;28575669;31219806;31599954;34428180;36210013;36517592;37453647;37507081;8250879", "class_list": "", "function": "Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes (PubMed:36517592). May play a role in the embryonic brain development (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P45634;Q569M8;Q5M9K8", "ec_number_list": "", "go_molecular_function": "GO:0045182 translation regulator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6ZWV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61514-1", "uniprot_id": "RL37A_MOUSE", "mass": 10275.0, "length": 92, "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "Rpl37a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL43", "refseq_ac": "NP_033110", "gene_names_uniprotkb": "Rpl37a", "gene_names_refseq": "Rpl37a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL43; 60S ribosomal protein L37a", "protein_names_refseq": "60S ribosomal protein L37a; large ribosomal subunit protein eL43", "tax_id": 10090, "disease": "", "pathway": " (mmu:19981); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "21750661;26740625;31219806;34428180;35820727;35984892;36517592;37453647;39627609;8415004", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12751", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61514-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CTN4-1", "uniprot_id": "RHBT3_MOUSE", "mass": 69208.0, "length": 611, "protein_name": "Rho-related BTB domain-containing protein 3", "gene_name": "Rhobtb3", "organism": "Mouse", "refseq_name": "rho-related BTB domain-containing protein 3 isoform 1", "refseq_ac": "NP_082769", "gene_names_uniprotkb": "Rhobtb3; Kiaa0878", "gene_names_refseq": "1700040C17Rik; 2610033K01Rik; 4930503C18Rik; Rhobtb3; mKIAA0878", "protein_names_uniprotkb": "Rho-related BTB domain-containing protein 3; 3.6.1.-", "protein_names_refseq": "rho-related BTB domain-containing protein 3 isoform 1; rho-related BTB domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73296); (R-MMU-6811440); (R-MMU-9706019)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12426103;21750661;25428506;30084848;30754723;32720791", "class_list": "", "function": "Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway., [RefSeq, PubMed]; Genetic deletion of Rhobtb3 leads to subtle alterations in alpha-granule secretion and adhesion to collagen without significant effects on hemostasis in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05DP2;Q3UTS4;Q80X55;Q9CVT0", "ec_number_list": "3.6.5.2;3.6.1.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0008584 male gonad development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CTN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCI9-1", "uniprot_id": "RM32_MOUSE", "mass": 21733.0, "length": 187, "protein_name": "Large ribosomal subunit protein bL32m", "gene_name": "Mrpl32", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL32m", "refseq_ac": "NP_083547", "gene_names_uniprotkb": "Mrpl32; Heg1", "gene_names_refseq": "0610033O15Rik; Mrpl32", "protein_names_uniprotkb": "Large ribosomal subunit protein bL32m; 39S ribosomal protein L32, mitochondrial; Heart-expressed gene 1 protein; L32mt; MRP-L32", "protein_names_refseq": "39S ribosomal protein L32, mitochondrial; L32mt; MRP-L32; heart-expressed gene 1 protein; large ribosomal subunit protein bL32m", "tax_id": 10090, "disease": "", "pathway": " (mmu:75398); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9837999); (R-MMU-9937383)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "11279069;16239145;21750661;31219806", "class_list": "", "function": "Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XR6", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922Q2-1", "uniprot_id": "RIOK1_MOUSE", "mass": 64910.0, "length": 567, "protein_name": "Serine/threonine-protein kinase RIO1", "gene_name": "Riok1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase RIO1", "refseq_ac": "NP_077204", "gene_names_uniprotkb": "Riok1", "gene_names_refseq": "3110046C13Rik; 5430416A05Rik; Ad034; Riok1", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO1; 2.7.11.1; 3.6.1.-; RIO kinase 1", "protein_names_refseq": "serine/threonine-protein kinase RIO1", "tax_id": 10090, "disease": "colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:71340); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21081503;21183079;21750661;26495903", "class_list": "", "function": "Describes a function for human RIOK1 as a component of the protein arginine methyltransferase 5 complex, conferring specificity for nucleolin as a methylation substrate., [RefSeq, PubMed]; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methylation substrate. [provided by RefSeq, Feb 2011]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7D5;Q99LZ1;Q9CU84;Q9CXN9", "ec_number_list": "2.7.11.1;3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;2.7.11.25;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;2.7.11.24;3.1.-.-;2.7.12.2;2.7.12.1;2.7.11.22;7.6.2.1;2.7.10.2;3.6.1.5;2.7.11.-;2.7.11.4;2.7.11.10;3.4.24.-;3.6.-.-;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;3.1.3.1;3.9.1.1;2.7.2.3;2.7.11.12;2.7.11.23;3.6.1.-;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;2.7.1.153;2.7.1.137;3.6.4.6;2.7.1.40;2.7.11.21;3.6.5.-;3.6.1.15;3.1.4.-;2.7.11.39;2.3.1.-;5.6.2.-;7.2.2.-;2.7.11.31;7.6.2.16;2.3.1.48;4.1.1.32;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.38;2.7.4.3;2.1.1.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034709 methylosome;GO:0030688 preribosome, small subunit precursor;GO:0034708 methyltransferase complex", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q922Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61358-1", "uniprot_id": "RL27_MOUSE", "mass": 15798.0, "length": 136, "protein_name": "Large ribosomal subunit protein eL27", "gene_name": "Rpl27", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL27", "refseq_ac": "NP_035419", "gene_names_uniprotkb": "Rpl27", "gene_names_refseq": "Rpl27", "protein_names_uniprotkb": "Large ribosomal subunit protein eL27; 60S ribosomal protein L27", "protein_names_refseq": "60S ribosomal protein L27; large ribosomal subunit protein eL27", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 16 (Disease Ontology:DOID:0111893)", "pathway": " (mmu:19942); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 18, "publication_id_list": "21750661;23576753;25428506;25605945;26100019;30084848;32152506;33300544;33649389;33725478;34428180;35820727;36288343;36517592;37453647;37507081;37828378;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0006364 rRNA processing;GO:1904044 response to aldosterone", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P61358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84099-1", "uniprot_id": "RL19_MOUSE", "mass": 23466.0, "length": 196, "protein_name": "Large ribosomal subunit protein eL19", "gene_name": "Rpl19", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL19 isoform 1", "refseq_ac": "NP_033104", "gene_names_uniprotkb": "Rpl19", "gene_names_refseq": "Rpl19", "protein_names_uniprotkb": "Large ribosomal subunit protein eL19; 60S ribosomal protein L19", "protein_names_refseq": "60S ribosomal protein L19; large ribosomal subunit protein eL19 isoform 1; large ribosomal subunit protein eL19", "tax_id": 10090, "disease": "", "pathway": " (mmu:19921); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10671200;11738047;1702292;21750661;24463520;31219806;34428180;35820727;36288343;36517592;37453647;37507081;37828378;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P14118;P22908", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P84099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TBW2-1", "uniprot_id": "RM10_MOUSE", "mass": 29396.0, "length": 262, "protein_name": "Large ribosomal subunit protein uL10m", "gene_name": "Mrpl10", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL10m isoform 1 precursor", "refseq_ac": "NP_080430", "gene_names_uniprotkb": "Mrpl10", "gene_names_refseq": "0610040E02Rik; L10mt; MRP-L8; Mrpl10; Rpml8", "protein_names_uniprotkb": "Large ribosomal subunit protein uL10m; 39S ribosomal protein L10, mitochondrial; L10mt; MRP-L10", "protein_names_refseq": "39S ribosomal protein L10, mitochondrial; large ribosomal subunit protein uL10m isoform 1 precursor; large ribosomal subunit protein uL10m", "tax_id": 10090, "disease": "", "pathway": " (mmu:107732); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "20042612;21750661;28135057", "class_list": "", "function": "Data describe the regulation of mitochondrial protein synthesis by the reversible acetylation of the mitochondrial ribosome and characterize MRPL10 as a novel substrate of the NAD(+)-dependent deacetylase, SIRT3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQD2", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TBW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AGA4-1", "uniprot_id": "RHBL2_MOUSE", "mass": 33735.0, "length": 302, "protein_name": "Rhomboid-related protein 2", "gene_name": "Rhbdl2", "organism": "Mouse", "refseq_name": "rhomboid-related protein 2 isoform 1", "refseq_ac": "NP_898986", "gene_names_uniprotkb": "Rhbdl2", "gene_names_refseq": "9130416B15; RRP2; Rhbdl2", "protein_names_uniprotkb": "Rhomboid-related protein 2; 3.4.21.105; RRP2", "protein_names_refseq": "rhomboid, veinlet-like 2; rhomboid-related protein 2 isoform 1; rhomboid-related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230726)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21439629;21833011", "class_list": "", "function": "RHBDL2 and soluble thrombomodulin were upregulated in ex vivo tissue culture of injured mouse skin. 3,4-Dichloroisocoumarin inhibited thrombomodulin production and wound healing; this was reversed by recombinant thrombomodulin in mice., [RefSeq, PubMed]; Regulator of proteosome activity independent of enzymatic activity (By similarity). Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AGA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D304-1", "uniprot_id": "RN128_MOUSE", "mass": 46276.0, "length": 428, "protein_name": "E3 ubiquitin-protein ligase RNF128", "gene_name": "Rnf128", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF128 isoform 2", "refseq_ac": "NP_001241690", "gene_names_uniprotkb": "Rnf128; Grail; Greul1; MNCb-3816", "gene_names_refseq": "1300002C13Rik; GRAIL; Greul1; Rnf128", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF128; 2.3.2.27; Gene related to anergy in lymphocytes protein; Goliath-related E3 ubiquitin-protein ligase 1; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF128 isoform 2; E3 ubiquitin-protein ligase RNF128; RING-type E3 ubiquitin transferase RNF128; gene related to anergy in lymphocytes protein; goliath-related E3 ubiquitin-protein ligase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66889); (R-MMU-5689880); (R-MMU-5689896)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12435366;12705856;21750661;25605945;37344492;37820291", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes 'Lys-27', 'Lys-48'- or 'Lys-63'-linked polyubiquitin chains formation and plays a role in different biological processes such as modulation of immune response, cytoskeletal dynamics or protein homeostasis (PubMed:12705856, PubMed:37344492). Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytoskeletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. Plays a positive role in innate immune response by promoting 'Lys-63'-linked ubiquitination of TBK1 after RNA- or DNA-virus infection. Regulates alveolar macrophage activation and neutrophil infiltration by interacting with TLR4, targeting it for degradation, and inhibiting NF-kappa-B activation, hence decreasing pro-inflammatory cytokines (PubMed:37344492). Negatively regulates the IL-3/STAT5 signaling pathway by facilitating 'Lys-27'-linked polyubiquitination of IL3RA leading to its degradation via lysosomal pathway. Directly regulates the N-glycosylation process in the endoplasmic reticulum by targeting the glycosyl-transferase RPN1 for ubiquitination and degradation. Other substrates targeted for degradation by RNF128 include transmembrane proteins CD40L, CD83 or the tetraspanin CD151., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; GRAIL gene knockout mice protect against aging-related and noise-induced hearing loss., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJY0;Q9CVG1;Q9DBN3;Q9JJF8", "ec_number_list": "2.3.2.27;3.4.19.12;3.6.5.2", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0001818 negative regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D304-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAQ4-1", "uniprot_id": "REXO4_MOUSE", "mass": 47599.0, "length": 432, "protein_name": "RNA exonuclease 4", "gene_name": "Rexo4", "organism": "Mouse", "refseq_name": "RNA exonuclease 4 isoform 1", "refseq_ac": "NP_997117", "gene_names_uniprotkb": "Rexo4; Gm111; Pmc2; Xpmc2h", "gene_names_refseq": "Gm111; Rex4; Rexo4; Xpmc2h", "protein_names_uniprotkb": "RNA exonuclease 4; 3.1.-.-; Exonuclease XPMC2; Prevents mitotic catastrophe 2 protein homolog", "protein_names_refseq": "REX4, RNA exonuclease 4 homolog; RNA exonuclease 4 isoform 1; RNA exonuclease 4; XPMC2 prevents mitotic catastrophe 2 homolog; Xenopus prevents mitotic catastrophe 2 homolog; exonuclease XPMC2; prevents mitotic catastrophe 2 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:227656)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;40021952", "class_list": "", "function": "May function as an exonuclease., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU17;Q8C524", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0004519 endonuclease activity;GO:0008408 3'-5' exonuclease activity;GO:0004527 exonuclease activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006281 DNA repair;GO:0006396 RNA processing;GO:0006364 rRNA processing;GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PAQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61255-1", "uniprot_id": "RL26_MOUSE", "mass": 17258.0, "length": 145, "protein_name": "Large ribosomal subunit protein uL24", "gene_name": "Rpl26", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL24", "refseq_ac": "NP_033106", "gene_names_uniprotkb": "Rpl26", "gene_names_refseq": "Rpl26; SIG-20", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24; 60S ribosomal protein L26; SIG-20; Silica-induced gene 20 protein", "protein_names_refseq": "60S ribosomal protein L26; large ribosomal subunit protein uL24; silica-induced gene 20 protein", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 11 (Disease Ontology:DOID:0111892)", "pathway": " (mmu:19941); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 17, "publication_id_list": "16213212;21183079;21750661;23806337;26100019;26495903;31219806;33649389;34428180;35820727;35984892;36288343;36517592;37453647;37507081;39627609;7868905", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:26100019, PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:26100019, PubMed:36517592)., [UniProtKB, PubMed, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB]; These findings demonstrate the importance of increased translation of p53 in DNA-damage responses and suggest critical roles for RPL26 and nucleolin in affecting p53 induction. Erratum:[Cell. 2005 Nov 4;123(3):536-7], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q02877", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043195 terminal bouton", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0042273 ribosomal large subunit biogenesis;GO:0006941 striated muscle contraction;GO:0071479 cellular response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P61255-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZM2-1", "uniprot_id": "RL15_MOUSE", "mass": 24146.0, "length": 204, "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "Rpl15", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL15", "refseq_ac": "NP_079862", "gene_names_uniprotkb": "Rpl15", "gene_names_refseq": "2510008H07Rik; Rpl15", "protein_names_uniprotkb": "Large ribosomal subunit protein eL15; 60S ribosomal protein L15", "protein_names_refseq": "60S ribosomal protein L15; large ribosomal subunit protein eL15", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 12 (Disease Ontology:DOID:0111882)", "pathway": " (mmu:66480); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 20, "publication_id_list": "16608517;18299400;19224205;20173027;21750661;21952136;25428506;25428507;30084848;31219806;33300544;33649389;34428180;35984892;36210013;36517592;37453647;37507081;37828378;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]; RPL15 promotes cell proliferation in gastric neoplasms Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWI5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9CZM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59729-1", "uniprot_id": "RIN3_MOUSE", "mass": 107220.0, "length": 980, "protein_name": "Ras and Rab interactor 3", "gene_name": "Rin3", "organism": "Mouse", "refseq_name": "ras and Rab interactor 3 isoform 1", "refseq_ac": "NP_808288", "gene_names_uniprotkb": "Rin3", "gene_names_refseq": "6430500K07; Rin3", "protein_names_uniprotkb": "Ras and Rab interactor 3; Ras interaction/interference protein 3", "protein_names_refseq": "Ras interaction/interference protein 3; ras and Rab interactor 3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217835); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;30059200;31219806;32552912;34428180", "class_list": "", "function": "Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function (By similarity)., [UniProtKB]; Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2RQF8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007165 signal transduction;GO:0016192 vesicle-mediated transport;GO:0097494 regulation of vesicle size;GO:0002091 negative regulation of receptor internalization;GO:0060755 negative regulation of mast cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P59729-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1W3-1", "uniprot_id": "RN103_MOUSE", "mass": 79189.0, "length": 683, "protein_name": "E3 ubiquitin-protein ligase RNF103", "gene_name": "Rnf103", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF103 isoform 1", "refseq_ac": "NP_033569", "gene_names_uniprotkb": "Rnf103; Zfp103", "gene_names_refseq": "Rnf103; Zfp103; kf-1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF103; 2.3.2.27; KF-1; RING finger protein 103; RING-type E3 ubiquitin transferase RNF103; Zfp-103; Zinc finger protein 103; mKF-1", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF103 isoform 1; E3 ubiquitin-protein ligase RNF103; RING-type E3 ubiquitin transferase RNF103; zinc finger protein 103", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:22644)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;18299400;21455683;21750661;21952136;31219806;34428180;9070305", "class_list": "", "function": "Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway., [UniProtKB, UniProtKB]; Studies indicate that the kf-1 null mice should be useful in elucidating the molecular mechanisms of the anxiety regulation., [RefSeq, PubMed]; This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EHC2;O08670;O08883", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R1W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61103-1", "uniprot_id": "REQU_MOUSE", "mass": 44230.0, "length": 391, "protein_name": "Zinc finger protein ubi-d4", "gene_name": "Dpf2", "organism": "Mouse", "refseq_name": "zinc finger protein ubi-d4 isoform 1", "refseq_ac": "NP_001278007", "gene_names_uniprotkb": "Dpf2; Baf45d; Req; Ubid4", "gene_names_refseq": "2210010M07Rik; BAF45D; Dpf2; Req; ubi-d4", "protein_names_uniprotkb": "Zinc finger protein ubi-d4; Apoptosis response zinc finger protein; BAF45D; BRG1-associated factor 45D; D4, zinc and double PHD fingers family 2; Protein requiem", "protein_names_refseq": "BRG1-associated factor 45D; D4, zinc and double PHD fingers family 2; apoptosis response zinc finger protein; neuro-d4/requiem; protein requiem; zinc finger protein ubi-d4 isoform 1; zinc finger protein ubi-d4", "tax_id": 10090, "disease": "Coffin-Siris syndrome 7 (Disease Ontology:DOID:0112369); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:19708); (R-MMU-9933937); (R-MMU-9933946); (R-MMU-9934037)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10602997;17242355;17640523;21183079;21750661;30609396;31219806;34428180;36210013;37200093;7961935;9680388", "class_list": "", "function": "Dpf2 Loss Affects ESC Self-Renewal and Leads to Increased Apoptosis and Cell-Cycle Defects., [RefSeq, PubMed]; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells (PubMed:7961935). Involved in the regulation of non-canonical NF-kappa-B pathway (By similarity)., [UniProtKB, UniProtKB, PubMed]; The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNP5;Q60663;Q9QYA3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0140015 histone H3K14ac reader activity;GO:0140046 histone H4K16ac reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PEE3-1", "uniprot_id": "RIR2B_MOUSE", "mass": 40804.0, "length": 351, "protein_name": "Ribonucleoside-diphosphate reductase subunit M2 B", "gene_name": "Rrm2b", "organism": "Mouse", "refseq_name": "ribonucleoside-diphosphate reductase subunit M2 B isoform 1", "refseq_ac": "NP_955770", "gene_names_uniprotkb": "Rrm2b; P53r2", "gene_names_refseq": "Rrm2b; p53R2", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase subunit M2 B; 1.17.4.1; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2", "protein_names_refseq": "TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; ribonucleoside-diphosphate reductase subunit M2 B isoform 1; ribonucleoside-diphosphate reductase subunit M2 B", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 8a (Disease Ontology:DOID:0080127); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518)", "pathway": " (mmu:382985); (R-MMU-499943)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11517226;12858174;21750661;25605945;31519977;32876667;34428180;34599703", "class_list": "", "function": "Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage., [UniProtKB, PubMed, PubMed]; Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out., [RefSeq, PubMed]; Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein., [RefSeq, PubMed]; Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells., [RefSeq, PubMed]; Rrm2b deletion causes mitochondrial metabolic defects in renal tubules. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0001822 kidney development;GO:0003014 renal system process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PEE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIT1-1", "uniprot_id": "RNF32_MOUSE", "mass": 42139.0, "length": 368, "protein_name": "RING finger protein 32", "gene_name": "Rnf32", "organism": "Mouse", "refseq_name": "RING finger protein 32", "refseq_ac": "NP_001276686", "gene_names_uniprotkb": "Rnf32; Lmbr2", "gene_names_refseq": "1700009J01Rik; 2700025B22Rik; 4930542N22Rik; Lmbr2; Rnf32", "protein_names_uniprotkb": "RING finger protein 32; Limb region protein 2", "protein_names_refseq": "RING finger protein 32; limb region protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56874)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10945466;21750661", "class_list": "", "function": "May play a role in sperm formation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9X0;Q9DAJ3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0016235 aggresome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBU5-1", "uniprot_id": "RNF6_MOUSE", "mass": 74091.0, "length": 667, "protein_name": "E3 ubiquitin-protein ligase RNF6", "gene_name": "Rnf6", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF6 isoform 1", "refseq_ac": "NP_001243014", "gene_names_uniprotkb": "Rnf6", "gene_names_refseq": "1200013I08Rik; 5730419H05Rik; Rnf6", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF6; 2.3.2.27; RLIM-like protein", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF6 isoform 1; E3 ubiquitin-protein ligase RNF6; RING-type E3 ubiquitin transferase RNF6; RLIM-like protein", "tax_id": 10090, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:74132); (R-MMU-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11971979;16204183;17242355;21183079;21750661;31219806;34428180;36088389;36210013", "class_list": "", "function": "E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (PubMed:16204183). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (PubMed:16204183). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (By similarity). May also bind DNA and function as a transcriptional regulator (PubMed:11971979). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (PubMed:36088389)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics Erratum:[Genes Dev. 2005 Nov 1;19(21):2643], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRR0;Q8K565", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0031965 nuclear membrane;GO:0016605 PML body", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0060765 regulation of androgen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DBU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C432-1", "uniprot_id": "RN182_MOUSE", "mass": 27444.0, "length": 247, "protein_name": "E3 ubiquitin-protein ligase RNF182", "gene_name": "Rnf182", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF182", "refseq_ac": "NP_899027", "gene_names_uniprotkb": "Rnf182", "gene_names_refseq": "C630023L15Rik; Rnf182", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF182; 2.3.2.27; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF182; RING-type E3 ubiquitin transferase RNF182", "tax_id": 10090, "disease": "", "pathway": " (mmu:328234); (R-MMU-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18298843;21750661", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAK3-1", "uniprot_id": "RHBT1_MOUSE", "mass": 78819.0, "length": 695, "protein_name": "Rho-related BTB domain-containing protein 1", "gene_name": "Rhobtb1", "organism": "Mouse", "refseq_name": "rho-related BTB domain-containing protein 1 isoform 1", "refseq_ac": "NP_001074816", "gene_names_uniprotkb": "Rhobtb1", "gene_names_refseq": "1700008H16Rik; 3110048G13Rik; Rhobtb1", "protein_names_uniprotkb": "Rho-related BTB domain-containing protein 1; 3.6.5.2", "protein_names_refseq": "rho-related BTB domain-containing protein 1 isoform 1; rho-related BTB domain-containing protein 1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 64 (Disease Ontology:DOID:0070375)", "pathway": " (mmu:69288); (R-MMU-9013422)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12426103;21750661;30896450;31219806;34428180", "class_list": "", "function": "RhoBTB1 protected from hypertension, vascular smooth muscle dysfunction, and arterial stiffness in at least two models of hypertension. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RPX3", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;2.7.11.39;3.6.1.-;2.3.2.27;3.6.1.15;2.7.11.1;3.6.-.-;3.1.4.-;3.1.4.35", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0010008 endosome membrane;GO:0042995 cell projection", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DAK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83882-1", "uniprot_id": "RL36A_MOUSE", "mass": 12441.0, "length": 106, "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "Rpl36a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL42", "refseq_ac": "NP_063918", "gene_names_uniprotkb": "Rpl36a; Rpl44", "gene_names_refseq": "L44L; Rpl36a; Rpl44", "protein_names_uniprotkb": "Large ribosomal subunit protein eL42; 60S ribosomal protein L36a; 60S ribosomal protein L44", "protein_names_refseq": "60S ribosomal protein L36a; 60S ribosomal protein L44; large ribosomal subunit protein eL42; ribosomal protein L44", "tax_id": 10090, "disease": "", "pathway": " (mmu:19982); (mmu:66483); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "21750661;22645316;33300544;35820727;36517592;37453647;7626884", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09896;P10661", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P83882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70426-1", "uniprot_id": "RIT1_MOUSE", "mass": 25169.0, "length": 219, "protein_name": "GTP-binding protein Rit1", "gene_name": "Rit1", "organism": "Mouse", "refseq_name": "GTP-binding protein Rit1 isoform 1", "refseq_ac": "NP_033095", "gene_names_uniprotkb": "Rit1; Rit", "gene_names_refseq": "RIBB; ROC1; Rit1; Rit", "protein_names_uniprotkb": "GTP-binding protein Rit1; 3.6.5.2; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1", "protein_names_refseq": "GTP-binding protein Rit1 isoform 1; GTP-binding protein Rit1; RAS-like protein expressed in many tissues; ras-like without CAAX protein 1", "tax_id": 10090, "disease": "Noonan syndrome 8 (Disease Ontology:DOID:0060586); RASopathy (Disease Ontology:DOID:0080690); Noonan syndrome (Disease Ontology:DOID:3490); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:19769)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10869344;15831491;21737674;21750661;22815504;39084876;8824319", "class_list": "", "function": "Our studies establish the Rit GTPases as critical regulators of an evolutionarily conserved, p38 MAPK-dependent signaling cascade, [RefSeq, PubMed]; Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation (By similarity). Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation (By similarity). Recognized by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB]; Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation, [RefSeq, PubMed]; Rit1-TBC1D10B signaling modulates FcgammaR-mediated phagosome formation in RAW264 macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; These data identify a new and unexpected role for Rit in injury-induced neurogenesis, functioning as a selective survival mechanism for immature hippocampal neurons within the subgranular zone of the dentate gyrus following TBI., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62984-1", "uniprot_id": "RL40_MOUSE", "mass": 14728.0, "length": 128, "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "Uba52", "organism": "Mouse", "refseq_name": "ubiquitin-ribosomal protein eL40 fusion protein precursor", "refseq_ac": "NP_001335156", "gene_names_uniprotkb": "Uba52; Ubcep2", "gene_names_refseq": "Cep52; D8Ertd21e; Gm1863; Rps27a; Uba52; Ubb; Ubc", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; 60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1", "protein_names_refseq": "60S ribosomal protein L40; ubiquitin-60S ribosomal protein L40; ubiquitin-ribosomal protein eL40 fusion protein precursor; ubiquitin-ribosomal protein eL40 fusion protein; ubiquitin/60S ribosomal fusion protein", "tax_id": 10090, "disease": "colon carcinoma (Disease Ontology:DOID:1520)", "pathway": " (mmu:22186); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1253288); (R-MMU-1295596); (R-MMU-1358803); (R-MMU-156827); (R-MMU-168638); (R-MMU-174048); (R-MMU-174084); (R-MMU-174113); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-179409); (R-MMU-1799339); (R-MMU-182971); (R-MMU-187577); (R-MMU-195253); (R-MMU-201681); (R-MMU-202424); (R-MMU-205043); (R-MMU-209543); (R-MMU-209560); (R-MMU-2122948); (R-MMU-2173788); (R-MMU-2173791); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-2467813); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-2565942); (R-MMU-2672351); (R-MMU-2871837); (R-MMU-3134975); (R-MMU-349425); (R-MMU-3769402); (R-MMU-382556); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-4641263); (R-MMU-5205685); (R-MMU-532668); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5675221); (R-MMU-5675482); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-5685942); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689877); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-5689901); (R-MMU-5693537); (R-MMU-5693565); (R-MMU-5693607); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6783310); (R-MMU-6791226); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804760); (R-MMU-6807004); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69231); (R-MMU-69481); (R-MMU-69541); (R-MMU-69601); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-75815); (R-MMU-8849469); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8863795); (R-MMU-8866427); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948747); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-901032); (R-MMU-9010553); (R-MMU-9013507); (R-MMU-9020702); (R-MMU-9033241); (R-MMU-909733); (R-MMU-912631); (R-MMU-917729); (R-MMU-917937); (R-MMU-936440); (R-MMU-936964); (R-MMU-937039); (R-MMU-937041); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-9646399); (R-MMU-9648002); (R-MMU-9664873); (R-MMU-9705462); (R-MMU-9706369); (R-MMU-9708530); (R-MMU-975144); (R-MMU-975163); (R-MMU-9755511); (R-MMU-9758274); (R-MMU-975956); (R-MMU-975957); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-9770562); (R-MMU-9824878); (R-MMU-983168); (R-MMU-9861718); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9931295); (R-MMU-9932298); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 169, "publication_count": 14, "publication_id_list": "10495888;19754430;21750661;25605945;28315936;31219806;33300544;34203471;34428180;35984892;36497031;36517592;37828378;39627609", "class_list": "", "function": "Component of the 60S subunit of the ribosome., [UniProtKB, PubMed, PubMed]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, PubMed]; UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P62991;Q29120;Q62317;Q64223;Q8VCH1;Q91887;Q91888;Q9CXY4;Q9CZM0;Q9D1R5;Q9D8D9;Q9ET23;Q9ET24;Q9Z0H9", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0016567 protein ubiquitination;GO:0006941 striated muscle contraction;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P62984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YQ8-1", "uniprot_id": "RMD5A_MOUSE", "mass": 43993.0, "length": 391, "protein_name": "E3 ubiquitin-protein ligase RMND5A", "gene_name": "Rmnd5a", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RMND5A", "refseq_ac": "NP_077250", "gene_names_uniprotkb": "Rmnd5a", "gene_names_refseq": "1110007A06Rik; Gid2; MTA.D02.090; Rmnd5a", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RMND5A; 2.3.2.27; Protein RMD5 homolog A", "protein_names_refseq": "E3 ubiquitin-protein ligase RMND5A; protein RMD5 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68477); (R-MMU-9861718)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18299400;19224205;20173027;21750661;21952136;25428506;30084848;34428180;35820727", "class_list": "", "function": "Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNK7;Q3TPH1;Q3UFE2", "ec_number_list": "1.1.1.27;2.7.10.2;2.7.11.1;2.7.1.40;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80YQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62193-1", "uniprot_id": "RFA2_MOUSE", "mass": 29440.0, "length": 270, "protein_name": "Replication protein A 32 kDa subunit", "gene_name": "Rpa2", "organism": "Mouse", "refseq_name": "replication protein A 32 kDa subunit isoform 1", "refseq_ac": "NP_035414", "gene_names_uniprotkb": "Rpa2; Rpa34", "gene_names_refseq": "RPA34; Rf-A2; Rpa2", "protein_names_uniprotkb": "Replication protein A 32 kDa subunit; RF-A protein 2; RP-A p32; RP-A p34; Replication factor A protein 2; Replication protein A 34 kDa subunit", "protein_names_refseq": "30-kDa protein; RF-A protein 2; RP-A p32; RP-A p34; replication factor A protein 2; replication protein A 32 kDa subunit isoform 1; replication protein A 32 kDa subunit; replication protein A 34 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:19891); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174437); (R-MMU-176187); (R-MMU-3371453); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693607); (R-MMU-5696395); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6783310); (R-MMU-6804756); (R-MMU-68962); (R-MMU-69166); (R-MMU-69473)", "pathway_count": 27, "publication_count": 3, "publication_id_list": "17141802;1908076;21750661", "class_list": "", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE40", "ec_number_list": "", "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0003684 damaged DNA binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006284 base-excision repair;GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1H0-1", "uniprot_id": "RITA1_MOUSE", "mass": 27071.0, "length": 253, "protein_name": "RBPJ-interacting and tubulin-associated protein 1", "gene_name": "Rita1", "organism": "Mouse", "refseq_name": "RBPJ-interacting and tubulin-associated protein 1", "refseq_ac": "NP_083372", "gene_names_uniprotkb": "Rita1; 1110008J03Rik; Rita", "gene_names_refseq": "1110008J03Rik; Rita1; Rita", "protein_names_uniprotkb": "RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein", "protein_names_refseq": "RBPJ-interacting and tubulin-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100764)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28487372", "class_list": "", "function": "Structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J., [RefSeq, PubMed]; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0051168 nuclear export;GO:0022008 neurogenesis;GO:0045746 negative regulation of Notch signaling pathway;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D1H0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41105-1", "uniprot_id": "RL28_MOUSE", "mass": 15733.0, "length": 137, "protein_name": "Large ribosomal subunit protein eL28", "gene_name": "Rpl28", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL28", "refseq_ac": "NP_033107", "gene_names_uniprotkb": "Rpl28", "gene_names_refseq": "D7Wsu21e; Rpl28", "protein_names_uniprotkb": "Large ribosomal subunit protein eL28; 60S ribosomal protein L28", "protein_names_refseq": "60S ribosomal protein L28; large ribosomal subunit protein eL28", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:19943); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 14, "publication_id_list": "21750661;25428506;25605945;30084848;31219806;34428180;35820727;35984892;36288343;36517592;37453647;37828378;39627609;7515017", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P41105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1P0-1", "uniprot_id": "RM13_MOUSE", "mass": 20677.0, "length": 178, "protein_name": "Large ribosomal subunit protein uL13m", "gene_name": "Mrpl13", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL13m", "refseq_ac": "NP_081035", "gene_names_uniprotkb": "Mrpl13", "gene_names_refseq": "1110002D09Rik; Mrpl13", "protein_names_uniprotkb": "Large ribosomal subunit protein uL13m; 39S ribosomal protein L13, mitochondrial; L13mt; MRP-L13", "protein_names_refseq": "39S ribosomal protein L13, mitochondrial; L13mt; MRP-L13; large ribosomal subunit protein uL13m", "tax_id": 10090, "disease": "", "pathway": " (mmu:68537); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0006412 translation;GO:0017148 negative regulation of translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D1P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXP0-1", "uniprot_id": "RHCG_MOUSE", "mass": 54972.0, "length": 498, "protein_name": "Ammonium transporter Rh type C", "gene_name": "Rhcg", "organism": "Mouse", "refseq_name": "ammonium transporter Rh type C", "refseq_ac": "NP_062773", "gene_names_uniprotkb": "Rhcg", "gene_names_refseq": "Rhcg", "protein_names_uniprotkb": "Ammonium transporter Rh type C; Rh family type C glycoprotein; Rh type C glycoprotein; Rhesus blood group family type C glycoprotein; Rhesus blood group-associated C glycoprotein; Rhesus-associated C glycoprotein", "protein_names_refseq": "Rh type C glycoprotein; ammonium transporter Rh type C; rh family type C glycoprotein; rhesus blood group family type C glycoprotein; rhesus-associated C glycoprotein", "tax_id": 10090, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); kidney failure (Disease Ontology:DOID:1074); renal tubular acidosis (Disease Ontology:DOID:14219); hypokalemia (Disease Ontology:DOID:4500)", "pathway": " (mmu:56315); (R-MMU-444411)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10852913;12388412;12595489;12730882;15576624;16131648;21750661;24338819;24647713;24652796;26354748;29054531;35820727", "class_list": "", "function": "Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity) (PubMed:16131648). May act as a CO2 channel providing for renal acid secretion (By similarity)., [UniProtKB, PubMed, UniProtKB]; Investigated the renal adaptive response of acid excretory pathways to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA) and examined how this adaption requires the RhCG ammonia transporter, [RefSeq, PubMed]; Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney., [RefSeq, PubMed]; Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion. Review article, [RefSeq, PubMed]; RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport., [RefSeq, PubMed]; RhCG and H+ATPases are located within the same cellular protein complex in the kidney and this interaction is required for maximal urinary acidification by H+-ATPases, a prerequisite for efficient NH3 secretion and urine excretion of NH4+., [RefSeq, PubMed]; RhCG immunoreactivity is present in bile duct epithelial cells, where it may contribute to ammonium secretion into bile fluid., [RefSeq, PubMed]; Rhcg is critically important in the renal response to metabolic acidosis. in mice with intact Rhcg expression, metabolic acidosis does not induce maximal changes in PEPCK, NHE-3, and GS expression despite the presence of persistent metabolic acidosis., [RefSeq, PubMed]; We characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes. We used ion-selective microelectrodes and two-electrode voltage clamp to measure changes in intracellular pH, surface pH, and whole cell currents induced by NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+))., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVS0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0070634 transepithelial ammonium transport;GO:0006873 intracellular monoatomic ion homeostasis;GO:0072488 ammonium transmembrane transport;GO:0006885 regulation of pH", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QXP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14115-1", "uniprot_id": "RL27A_MOUSE", "mass": 16605.0, "length": 148, "protein_name": "Large ribosomal subunit protein uL15", "gene_name": "Rpl27a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL15", "refseq_ac": "NP_036105", "gene_names_uniprotkb": "Rpl27a", "gene_names_refseq": "L27'; L27A; L29; Rpl27a", "protein_names_uniprotkb": "Large ribosomal subunit protein uL15; 60S ribosomal protein L27a; L29", "protein_names_refseq": "60S ribosomal protein L27a; large ribosomal subunit protein uL15; ribosomal protein L29 homolog", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:26451); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-9629569); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "10449908;11528127;21183079;21750661;2434927;33725478;34428180;35820727;36517592;37453647;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ16;Q9R1X6", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P14115-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVL4-1", "uniprot_id": "GRK1_MOUSE", "mass": 63837.0, "length": 564, "protein_name": "Rhodopsin kinase GRK1", "gene_name": "Grk1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Grk1; Rhok", "gene_names_refseq": "", "protein_names_uniprotkb": "Rhodopsin kinase GRK1; 2.7.11.14; G protein-coupled receptor kinase 1; RK", "protein_names_refseq": "", "tax_id": 10090, "disease": "Oguchi disease-2 (Disease Ontology:DOID:0110713); alcohol use disorder (Disease Ontology:DOID:1574); retinal disease (Disease Ontology:DOID:5679); congestive heart failure (Disease Ontology:DOID:6000); night blindness (Disease Ontology:DOID:8499)", "pathway": " (mmu:24013); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10097103;10704496;11717351;15961391;21504899;21750661;26427409;37507081", "class_list": "", "function": "Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:10097103, PubMed:10704496, PubMed:26427409). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (PubMed:10097103, PubMed:10704496). May play a role in the maintenance of the outer nuclear layer in the retina (PubMed:26427409)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.16;2.7.11.14;2.7.11.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0007601 visual perception;GO:0046777 protein autophosphorylation;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62947-1", "uniprot_id": "RS32_MOUSE", "mass": 3456.0, "length": 25, "protein_name": "Small ribosomal subunit protein eS32", "gene_name": "Rpl41", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS32", "refseq_ac": "NP_061348", "gene_names_uniprotkb": "Rpl41", "gene_names_refseq": "1810055P16Rik; 2210411K19Rik; Rpl41", "protein_names_uniprotkb": "Small ribosomal subunit protein eS32; 60S ribosomal protein L41; Large ribosomal subunit protein eL41", "protein_names_refseq": "60S ribosomal protein L41; large ribosomal subunit protein eL41; small ribosomal subunit protein eS32", "tax_id": 10090, "disease": "", "pathway": " (mmu:67945)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;36517592;37828378", "class_list": "", "function": "Component of the small ribosomal subunit (Probable) (Ref.4). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H625;P28751;Q3UCJ7", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62947-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3C0-1", "uniprot_id": "RNK_MOUSE", "mass": 10992.0, "length": 98, "protein_name": "Ribonuclease kappa", "gene_name": "Rnasek", "organism": "Mouse", "refseq_name": "ribonuclease kappa", "refseq_ac": "NP_776103", "gene_names_uniprotkb": "Rnasek; D11Bwg0434e; Gm21988", "gene_names_refseq": "2310033H11Rik; D11Bwg0434e; Rnasek", "protein_names_uniprotkb": "Ribonuclease kappa; 3.1.-.-; RNase K; RNase kappa; V-ATPase subunit f; V-type proton ATPase subunit f", "protein_names_refseq": "RNase K; RNase kappa; V-ATPase subunit f; V-type proton ATPase subunit f; ribonuclease kappa", "tax_id": 10090, "disease": "", "pathway": " (mmu:52898)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;31219806", "class_list": "", "function": "Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (By similarity). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity). Required at an early stage of receptor-mediated endocytosis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAB4", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0030665 clathrin-coated vesicle membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0048388 endosomal lumen acidification;GO:0019065 receptor-mediated endocytosis of virus by host cell;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K3C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWY9-1", "uniprot_id": "RIP_MOUSE", "mass": 24897.0, "length": 219, "protein_name": "RPA-interacting protein", "gene_name": "Rpain", "organism": "Mouse", "refseq_name": "RPA-interacting protein isoform 3", "refseq_ac": "NP_001239342", "gene_names_uniprotkb": "Rpain; Rip", "gene_names_refseq": "2400006N03Rik; Rip; Rpain", "protein_names_uniprotkb": "RPA-interacting protein", "protein_names_refseq": "RPA interacting protein delta 2; RPA interacting protein epsilon; RPA-interacting protein isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69723)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19192389;21750661", "class_list": "", "function": "Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity)., [UniProtKB]; The alternative splicing of RIPalpha in the Drosophila, Xenopus, and mouse system, was examined., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0016605 PML body", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0009411 response to UV;GO:0006261 DNA-templated DNA replication;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CWY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08848-1", "uniprot_id": "RO60_MOUSE", "mass": 60124.0, "length": 538, "protein_name": "RNA-binding protein Ro60", "gene_name": "RO60", "organism": "Mouse", "refseq_name": "RNA-binding protein Ro60", "refseq_ac": "NP_038863", "gene_names_uniprotkb": "RO60; Ssa2; Trove2", "gene_names_refseq": "1810007I17Rik; A530054J02Rik; Ro60; SS-A/Ro; Ssa2; Ssa; Trove2", "protein_names_uniprotkb": "RNA-binding protein Ro60; 60 kDa Ro protein; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; RoRNP; TROVE domain family member 2", "protein_names_refseq": "60 kDa Ro protein; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; RNA-binding protein Ro60; Sjogren syndrome antigen A2; TROVE domain family, member 2; roRNP", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:20822)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10323459;11196703;12121436;21289087;24576620;25370295;25428506;30084848;30395870;30779550;34428180;34843735;35909659;9112230", "class_list": "", "function": "IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (By similarity). May play roles in cilia formation and/or maintenance (PubMed:21289087)., [UniProtKB, UniProtKB, PubMed]; Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity., [RefSeq, PubMed]; Ro60 ameliorated the severity of dextran sodium sulfate -induced colitis in mice by repressing inflammation, fibrosis, angiogenesis, and the production of reactive oxygen species Erratum:[Immunol Lett. 2019 Aug;212:132. doi: 10.1016/j.imlet.2019.01.001. PMID: 30638737], [RefSeq, PubMed]; These data support the hypothesis that antibodies to Ro274 deposit in salivary glands can enter intact salivary gland cells and are involved in the dysregulation of salivary flow in SS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYD8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0010468 regulation of gene expression;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O08848-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09167-1", "uniprot_id": "RL21_MOUSE", "mass": 18579.0, "length": 160, "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "Rpl21", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL21", "refseq_ac": "NP_062621", "gene_names_uniprotkb": "Rpl21", "gene_names_refseq": "8430440E03Rik; L21; Rpl21", "protein_names_uniprotkb": "Large ribosomal subunit protein eL21; 60S ribosomal protein L21", "protein_names_refseq": "60S ribosomal protein L21; large ribosomal subunit protein eL21", "tax_id": 10090, "disease": "hypotrichosis 12 (Disease Ontology:DOID:0110709)", "pathway": " (mmu:19933); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 8, "publication_id_list": "20043235;28528544;36288343;36517592;37062845;37453647;37507081;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; RPL21 interacts with LAMP3 to promote colorectal cancer invasion and metastasis by regulating focal adhesion formation. Publication Status: Online-Only, [RefSeq, PubMed]; Rpl21 participates in the synthesis of various polypeptides which might be related to the initiation and the development of tooth germ, and also in the synthesis of enamel components in the presecretory stage of the ameloblast., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQM8", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0001650 fibrillar center", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O09167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35291-1", "uniprot_id": "RNAS2_MOUSE", "mass": 17723.0, "length": 155, "protein_name": "Non-secretory ribonuclease", "gene_name": "Rnase2", "organism": "Mouse", "refseq_name": "non-secretory ribonuclease precursor", "refseq_ac": "NP_001017422", "gene_names_uniprotkb": "Rnase2; Ear4", "gene_names_refseq": "Ear4; RNS2; Rnase2; mR4", "protein_names_uniprotkb": "Non-secretory ribonuclease; 4.6.1.18; Eosinophil cationic-type ribonuclease 4; MR-4; RNase 2; Ribonuclease 2", "protein_names_refseq": "eosinophil cationic-type ribonuclease 4; liver, eosinophil-derived neurotoxin; murine ribonuclease 4; non-secretory ribonuclease precursor; non-secretory ribonuclease; ribonuclease, RNase A family, 2", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156)", "pathway": " (mmu:53877)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18694936;9336452", "class_list": "", "function": "This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity;GO:0004522 ribonuclease A activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0006935 chemotaxis;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54828-1", "uniprot_id": "RGS9_MOUSE", "mass": 76978.0, "length": 675, "protein_name": "Regulator of G protein signaling 9", "gene_name": "Rgs9", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 9 isoform 1", "refseq_ac": "NP_035398", "gene_names_uniprotkb": "Rgs9", "gene_names_refseq": "RGS9-1; Rgs9-2; Rgs9", "protein_names_uniprotkb": "Regulator of G protein signaling 9; RGS9", "protein_names_refseq": "ROS GAP; regulator of G-protein signaling 9 isoform 1", "tax_id": 10090, "disease": "bradyopsia 1 (Disease Ontology:DOID:0070363); Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (mmu:19739); (R-MMU-2514859); (R-MMU-418594); (R-MMU-6814122)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10066255;11292825;12119397;12499365;14614075;15632198;15897264;16908407;21750661;30084848;30779550;33300544;34428180;9459445", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L352;Q9Z0S0", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0001975 response to amphetamine;GO:0007212 G protein-coupled dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O54828-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17932-1", "uniprot_id": "RL32P_MOUSE", "mass": 16011.0, "length": 135, "protein_name": "Putative large ribosomal subunit protein eL32'", "gene_name": "Rpl32-ps", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl32-ps", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative large ribosomal subunit protein eL32'; 60S ribosomal protein L32'", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2462715;25605945;3246356", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17932-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47915-1", "uniprot_id": "RL29_MOUSE", "mass": 17587.0, "length": 160, "protein_name": "Large ribosomal subunit protein eL29", "gene_name": "Rpl29", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL29", "refseq_ac": "NP_001311462", "gene_names_uniprotkb": "Rpl29; Rpl43", "gene_names_refseq": "Rpl29; Rpl43", "protein_names_uniprotkb": "Large ribosomal subunit protein eL29; 60S ribosomal protein L29", "protein_names_refseq": "60S ribosomal protein L29; large ribosomal subunit protein eL29", "tax_id": 10090, "disease": "", "pathway": " (mmu:19944); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11803571;21750661;23806337;25605945;31219806;33004906;33300544;33725478;34428180;35820727;35984892;36288343;36517592;37453647;37507081;37828378;8224911", "class_list": "", "function": "Analyzed the expression pattern in the mammary gland especially with respect to luminal epithelial cell growth and differentiation during pregnancy and lactation, [RefSeq, PubMed]; Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB]; The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0035264 multicellular organism growth;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P47915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47939-1", "uniprot_id": "RES18_MOUSE", "mass": 19485.0, "length": 175, "protein_name": "Regulated endocrine-specific protein 18", "gene_name": "Resp18", "organism": "Mouse", "refseq_name": "regulated endocrine-specific protein 18 precursor", "refseq_ac": "NP_033075", "gene_names_uniprotkb": "Resp18", "gene_names_refseq": "Resp18", "protein_names_uniprotkb": "Regulated endocrine-specific protein 18", "protein_names_refseq": "regulated endocrine-specific protein 18 precursor", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:19711)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17951542;21104147;29964075;7988462", "class_list": "", "function": "May play a regulatory role in corticotroph cells., [UniProtKB, PubMed]; RESP18 is a luminal protein of DCVs and its expression is regulated by exposure to glucose., [RefSeq, PubMed]; Requirement of regulated endocrine-specific protein-18 for development and expression of regulated endocrine-specific protein-18 isoform c in mice., [RefSeq, PubMed]; This gene encodes a secreted protein that is expressed mainly in the peripheral endocrine and neuroendocrine tissues and is regulated by physiological factors that include blood glucose and dopaminergic drugs. The encoded protein is found in the lumen of the endoplasmic reticulum and is degraded in the post-ER pre-Golgi compartment. Gene knockout experiments in mice demonstrate that this gene is essential for embryonic development with embryonic lethality occurring before embryonic day 9.5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9W0B0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0030141 secretory granule;GO:0043204 perikaryon;GO:0048237 rough endoplasmic reticulum lumen", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47939-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47955-1", "uniprot_id": "RLA1_MOUSE", "mass": 11475.0, "length": 114, "protein_name": "Large ribosomal subunit protein P1", "gene_name": "Rplp1", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein P1", "refseq_ac": "NP_061341", "gene_names_uniprotkb": "Rplp1", "gene_names_refseq": "2410042H16Rik; Arpp1; C430017H15Rik; Rplp1", "protein_names_uniprotkb": "Large ribosomal subunit protein P1; 60S acidic ribosomal protein P1", "protein_names_refseq": "60S acidic ribosomal protein P1; acidic ribosomal phosphoprotein P1; large ribosomal subunit protein P1; ribosomal protein, large, P1", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:56040); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 11, "publication_id_list": "16075062;19233166;25428506;26495903;30084848;30779550;31899515;32152506;34428180;37453647;39032642", "class_list": "", "function": "60S acidic ribosomal protein P1 (RPLP1) is elevated in human endometriotic tissue and in a murine model of endometriosis and is essential for endometriotic epithelial cell survival in vitro., [RefSeq, PubMed]; Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting., [RefSeq, PubMed]; Overexpression of a single ribosomal protein, Rplp1, is a cause and not a consequence of cell proliferation, [RefSeq, PubMed]; Plays an important role in the elongation step of protein synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0030295 protein kinase activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47955-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47963-1", "uniprot_id": "RL13_MOUSE", "mass": 24305.0, "length": 211, "protein_name": "Large ribosomal subunit protein eL13", "gene_name": "Rpl13", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL13", "refseq_ac": "NP_058018", "gene_names_uniprotkb": "Rpl13", "gene_names_refseq": "A52; L13; Rpl13", "protein_names_uniprotkb": "Large ribosomal subunit protein eL13; 60S ribosomal protein L13; A52", "protein_names_refseq": "60S ribosomal protein L13; large ribosomal subunit protein eL13", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia (Disease Ontology:DOID:0080027); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:270106); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 11, "publication_id_list": "21183079;25605945;26740625;34428180;35820727;35984892;36210013;36288343;36517592;37453647;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRZ9;Q9DCH1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0060348 bone development;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47963-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47964-1", "uniprot_id": "RL36_MOUSE", "mass": 12254.0, "length": 105, "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "Rpl36", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL36", "refseq_ac": "NP_061200", "gene_names_uniprotkb": "Rpl36", "gene_names_refseq": "Rpl36", "protein_names_uniprotkb": "Large ribosomal subunit protein eL36; 60S ribosomal protein L36", "protein_names_refseq": "60S ribosomal protein L36; large ribosomal subunit protein eL36", "tax_id": 10090, "disease": "", "pathway": " (mmu:54217)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22645316;24788674;36517592;37453647;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWZ4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62488-1", "uniprot_id": "RPB7_MOUSE", "mass": 19294.0, "length": 172, "protein_name": "DNA-directed RNA polymerase II subunit RPB7", "gene_name": "Polr2g", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase II subunit RPB7", "refseq_ac": "NP_080605", "gene_names_uniprotkb": "Polr2g", "gene_names_refseq": "2410046K11Rik; A230108L04Rik; Polr2g; RBP7; Rpo2-7l", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB7; DNA-directed RNA polymerase II subunit G; RNA polymerase II subunit B7", "protein_names_refseq": "DNA-directed RNA polymerase II subunit G; DNA-directed RNA polymerase II subunit RPB7; RNA polymerase II subunit B7", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:67710); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 22, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52433", "ec_number_list": "", "go_molecular_function": "GO:0003727 single-stranded RNA binding;GO:0003697 single-stranded DNA binding;GO:0016779 nucleotidyltransferase activity;GO:0031369 translation initiation factor binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000932 P-body;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62488-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62889-1", "uniprot_id": "RL30_MOUSE", "mass": 12784.0, "length": 115, "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "Rpl30", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL30", "refseq_ac": "NP_001156957", "gene_names_uniprotkb": "Rpl30", "gene_names_refseq": "Rpl30", "protein_names_uniprotkb": "Large ribosomal subunit protein eL30; 60S ribosomal protein L30", "protein_names_refseq": "60S ribosomal protein L30; large ribosomal subunit protein eL30", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); herpes simplex (Disease Ontology:DOID:8566)", "pathway": " (mmu:19946); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "21750661;31219806;34428180;35984892;36288343;36517592;37453647;37507081;39627609;6513928", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04645", "ec_number_list": "", "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0050829 defense response to Gram-negative bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86048-1", "uniprot_id": "RL10L_MOUSE", "mass": 24558.0, "length": 214, "protein_name": "Large ribosomal subunit protein uL16-like", "gene_name": "Rpl10l", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL16-like", "refseq_ac": "NP_001156405", "gene_names_uniprotkb": "Rpl10l", "gene_names_refseq": "EG238217; Rpl10l", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16-like; 60S ribosomal protein L10-like", "protein_names_refseq": "60S ribosomal protein L10-like; large ribosomal subunit protein uL16-like", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); spermatogenic failure 63 (Disease Ontology:DOID:0112356); autistic disorder (Disease Ontology:DOID:12849); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (mmu:238217); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "28502657;36517592", "class_list": "", "function": "Deficiency of Rpl10l disturbs ribosome biogenesis in late-prophase spermatocytes and prohibits the transition from prophase into metaphase of the first meiotic division, resulting in male infertility., [RefSeq, PubMed]; Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (PubMed:28502657). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:28502657). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28502657). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (PubMed:36517592). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (PubMed:36517592)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005840 ribosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P86048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97347-1", "uniprot_id": "RPTN_MOUSE", "mass": 128619.0, "length": 1118, "protein_name": "Repetin", "gene_name": "Rptn", "organism": "Mouse", "refseq_name": "repetin", "refseq_ac": "NP_033126", "gene_names_uniprotkb": "Rptn", "gene_names_refseq": "Rptn", "protein_names_uniprotkb": "Repetin", "protein_names_refseq": "repetin", "tax_id": 10090, "disease": "", "pathway": " (mmu:20129); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "30059200;34428180;9268637", "class_list": "", "function": "Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X968", "ec_number_list": "", "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0001533 cornified envelope", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05921-1", "uniprot_id": "RN5A_MOUSE", "mass": 83275.0, "length": 735, "protein_name": "2-5A-dependent ribonuclease", "gene_name": "Rnasel", "organism": "Mouse", "refseq_name": "2-5A-dependent ribonuclease", "refseq_ac": "NP_036012", "gene_names_uniprotkb": "Rnasel; Rns4", "gene_names_refseq": "E230029I04Rik; Rnasel", "protein_names_uniprotkb": "2-5A-dependent ribonuclease; 2-5A-dependent RNase; 3.1.26.-; RNase L; Ribonuclease 4; Ribonuclease L", "protein_names_refseq": "2-5A-dependent RNAase; 2-5A-dependent RNase; 2-5A-dependent ribonuclease; RNase L; ribonuclease 4", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:24014); (R-MMU-8983711); (R-MMU-909733)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11063255;11585831;21750661;23825954;25428506;29652922;34428180;37615181;38473966;7680958", "class_list": "", "function": "A novel role of RNase L in the development of nonalcoholic steatohepatitis., [RefSeq, PubMed]; Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover (By similarity). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length (By similarity). Involved in intercellular immune signaling. Cross-activated by 2',5'-oligoadenylates (2-5A) previously generated in RNA virus-infected cells, triggers type I interferon signaling in uninfected neighboring cells to limit local spread of infection., [UniProtKB, UniProtKB, PubMed]; Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERU7", "ec_number_list": "3.6.5.-;3.1.26.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q05921-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2WG77-1", "uniprot_id": "RIPP1_MOUSE", "mass": 21804.0, "length": 201, "protein_name": "Protein ripply1", "gene_name": "Ripply1", "organism": "Mouse", "refseq_name": "protein ripply1", "refseq_ac": "NP_001033004", "gene_names_uniprotkb": "Ripply1", "gene_names_refseq": "Ripply1", "protein_names_uniprotkb": "Protein ripply1", "protein_names_refseq": "protein ripply1; ripply1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:622473)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16326386;20346937;23727513", "class_list": "", "function": "Conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal properties, respectively, [RefSeq, PubMed]; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity)., [UniProtKB, UniProtKB]; Rostro-caudal pattern is established by dynamic interaction of Notch activity with two Mesp2 domains, which are defined in successive segmentation cycles by Notch, Tbx6 and Ripply1/2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0060349 bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2WG77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UF64-1", "uniprot_id": "RNFT2_MOUSE", "mass": 48856.0, "length": 445, "protein_name": "RING finger and transmembrane domain-containing protein 2", "gene_name": "Rnft2", "organism": "Mouse", "refseq_name": "RING finger and transmembrane domain-containing protein 2 isoform 2", "refseq_ac": "NP_001103372", "gene_names_uniprotkb": "Rnft2; Tmem118", "gene_names_refseq": "B830028P19Rik; Rnft2; Tmem118", "protein_names_uniprotkb": "RING finger and transmembrane domain-containing protein 2; Transmembrane protein 118", "protein_names_refseq": "RING finger and transmembrane domain-containing protein 2 isoform 2; ring finger and transmembrane domain-containing protein 2; transmembrane protein 118", "tax_id": 10090, "disease": "", "pathway": " (mmu:269695)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31990690", "class_list": "", "function": "E3 ubiquitin-protein ligase that negatively regulates IL3-dependent cellular responses through IL3RA ubiquitination and degradation by the proteasome, having an anti-inflammatory effect., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXI9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UF64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UIW8-1", "uniprot_id": "RN224_MOUSE", "mass": 17382.0, "length": 156, "protein_name": "RING finger protein 224", "gene_name": "Rnf224", "organism": "Mouse", "refseq_name": "RING finger protein 224", "refseq_ac": "NP_001028582", "gene_names_uniprotkb": "Rnf224; Gm757", "gene_names_refseq": "Gm757; Rnf224", "protein_names_uniprotkb": "RING finger protein 224", "protein_names_refseq": "RING finger protein 224", "tax_id": 10090, "disease": "", "pathway": " (mmu:329360)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UIW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ND29-1", "uniprot_id": "RILP_MOUSE", "mass": 41139.0, "length": 369, "protein_name": "Rab-interacting lysosomal protein", "gene_name": "Rilp", "organism": "Mouse", "refseq_name": "rab-interacting lysosomal protein", "refseq_ac": "NP_001025109", "gene_names_uniprotkb": "Rilp", "gene_names_refseq": "Gm857; Rilp", "protein_names_uniprotkb": "Rab-interacting lysosomal protein", "protein_names_refseq": "rab-interacting lysosomal protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:280408); (R-MMU-2132295)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20236428;22275436;22740695;31624142;32279353;36801641;38837607", "class_list": "", "function": "A Novel Role for RILP in Regulating Osteoclastogenesis and Bone Resorption., [RefSeq, PubMed]; A new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes is revealed through interaction with RILP and is involved in the centripetal movement of melanosomes., [RefSeq, PubMed]; A new pathway regulating insulin secretion and a novel function of RILP in modulating insulin secretion through mediating the lysosomal degradation of proinsulin., [RefSeq, PubMed]; CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7., [RefSeq, PubMed]; Cln1-mutations suppress Rab7-RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis., [RefSeq, PubMed]; Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes., [UniProtKB, UniProtKB]; Rab36 mediates retrograde melanosome transport in melanocytes through interaction with RILP., [RefSeq, PubMed]; Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WB8;Q8CHY9", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding;GO:0032935 sterol sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0042632 cholesterol homeostasis;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5ND29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZWV7-1", "uniprot_id": "RL35_MOUSE", "mass": 14553.0, "length": 123, "protein_name": "Large ribosomal subunit protein uL29", "gene_name": "Rpl35", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL29", "refseq_ac": "NP_079868", "gene_names_uniprotkb": "Rpl35", "gene_names_refseq": "2410039E09Rik; Rpl35", "protein_names_uniprotkb": "Large ribosomal subunit protein uL29; 60S ribosomal protein L35", "protein_names_refseq": "60S ribosomal protein L35; large ribosomal subunit protein uL29", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 19 (Disease Ontology:DOID:0111886)", "pathway": " (mmu:66489); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 7, "publication_id_list": "26495903;31361958;34428180;35820727;36517592;37453647;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6ZWV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQP4-1", "uniprot_id": "RL3R2_MOUSE", "mass": 45460.0, "length": 414, "protein_name": "Relaxin-3 receptor 2", "gene_name": "Rxfp4", "organism": "Mouse", "refseq_name": "relaxin-3 receptor 2", "refseq_ac": "NP_861538", "gene_names_uniprotkb": "Rxfp4; Gpr100; Rln3r2", "gene_names_refseq": "GPCR142; Gpr100; Rln3r2; Rxfp4; SALPR", "protein_names_uniprotkb": "Relaxin-3 receptor 2; G protein-coupled receptor 100; Insulin-like peptide INSL5 receptor; RLN3 receptor 2; Relaxin family peptide receptor 4", "protein_names_refseq": "G protein-coupled receptor 100; RLN3 receptor 2; insulin-like peptide INSL5 receptor; relaxin-3 receptor 2; relaxin-3/INSL7 receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:242093); (R-MMU-418594); (R-MMU-444821)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12679517;14623098;31989750;35820727;36184065;36947541", "class_list": "", "function": "Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor., [RefSeq, PubMed]; Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin., [RefSeq, PubMed]; High affinity receptor for INSL5. Also acts as a receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity)., [UniProtKB]; Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UD6", "ec_number_list": "", "go_molecular_function": "GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:2000253 positive regulation of feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TQP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XE1-2", "uniprot_id": "RIC8B_MOUSE", "mass": 58683.0, "length": 520, "protein_name": "Chaperone Ric-8B", "gene_name": "Ric8b", "organism": "Mouse", "refseq_name": "chaperone Ric-8B isoform 1", "refseq_ac": "NP_001013459", "gene_names_uniprotkb": "Ric8b", "gene_names_refseq": "Ric-8b; Ric-8; Ric8b", "protein_names_uniprotkb": "Chaperone Ric-8B; Synembryn-B", "protein_names_refseq": "chaperone Ric-8B isoform 1; chaperone Ric-8B; resistance to inhibitors of cholinesterase 8 homolog B; resistance to inhibitors of cholinesterase 8B; synembryn-B", "tax_id": 10090, "disease": "", "pathway": " (mmu:237422)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "15829631;16754875;18462949;20133939;21183079;21467038;22114146;22872234;25428506;29118104;30084848;32392211;33719582;34203471;34428180;36931277;38879012", "class_list": "", "function": "A crucial role for Ric-8B in development and novel insights into the signals that regulate mTORC2. Publication Status: Online-Only, [RefSeq, PubMed]; Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane (PubMed:22114146, PubMed:36931277). Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP (PubMed:15829631, PubMed:16754875, PubMed:21467038, PubMed:22114146). Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)-alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons (PubMed:15829631, PubMed:16754875, PubMed:29118104)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results show that Ric-8B, a putative guanine nucleotide exchange factor for Galphaolf, promotes efficient heterologous expression of odorant receptors., [RefSeq, PubMed]; Ric-8B interacts with two different olfactory G protein subunits and is implicated as an important protein in odorant signal transduction., [RefSeq, PubMed]; Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling, [RefSeq, PubMed]; The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart., [RefSeq, PubMed]; The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58L65", "ec_number_list": "", "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80XE1-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX84-1", "uniprot_id": "RGS19_MOUSE", "mass": 24678.0, "length": 216, "protein_name": "Regulator of G protein signaling 19", "gene_name": "Rgs19", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 19 isoform b", "refseq_ac": "NP_001278135", "gene_names_uniprotkb": "Rgs19", "gene_names_refseq": "2610042F04Rik; GAIP; Rgs19", "protein_names_uniprotkb": "Regulator of G protein signaling 19; RGS19", "protein_names_refseq": "G-alpha interacting protein; regulator of G-protein signaling 19 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:56470); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12507475;21750661;24775271;25766428;32848054;34428180", "class_list": "", "function": "Gene structure and transcription regulation, [RefSeq, PubMed]; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G protein (By similarity)., [UniProtKB]; Notch signaling positively regulates phosphorylation of Akt, possibly via phosphorylation of RGS19, [RefSeq, PubMed]; Our findings provide insight for the first time into the mechanisms involved in Rgs19 regulation of mouse ESC proliferation and differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99L50", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005903 brush border;GO:0030054 cell junction;GO:0030136 clathrin-coated vesicle;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CX84-1", "record_type": "protein" } ]