[ { "uniprot_canonical_ac": "Q05909-1", "uniprot_id": "PTPRG_MOUSE", "mass": 161243.0, "length": 1442, "protein_name": "Receptor-type tyrosine-protein phosphatase gamma", "gene_name": "Ptprg", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor", "refseq_ac": "NP_033007", "gene_names_uniprotkb": "Ptprg", "gene_names_refseq": "5430405N12Rik; Ptprg; RPTPgamma", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase gamma; 3.1.3.48; Protein-tyrosine phosphatase gamma; R-PTP-gamma", "protein_names_refseq": "Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma); R-PTP-gamma; receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor; receptor-type tyrosine-protein phosphatase gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:19270)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;20133774;21750661;25428506;26661205;27539848;30084848;30899004;32955439;33300544;34428180;35820727;36210013;8382771", "class_list": "", "function": "PTPRG is an ischemia risk locus essential for HCO3(-)-dependent regulation of endothelial function and tissue perfusion. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses tyrosine phosphatase activity., [UniProtKB, UniProtKB, UniProtKB]; Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system, [RefSeq, PubMed]; Vasoconstriction promoted through RPTPgamma-dependent changes in VSMC Ca(2+)-sensitivity, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004725 protein tyrosine phosphatase activity;GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0007165 signal transduction;GO:0031175 neuron projection development;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q05909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06180-1", "uniprot_id": "PTN2_MOUSE", "mass": 47360.0, "length": 406, "protein_name": "Tyrosine-protein phosphatase non-receptor type 2", "gene_name": "Ptpn2", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 2 isoform b", "refseq_ac": "NP_001120649", "gene_names_uniprotkb": "Ptpn2; Ptpt", "gene_names_refseq": "Ptpn2; Ptpt; TC-PTP", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 2; 3.1.3.48; MPTP; Protein-tyrosine phosphatase PTP-2", "protein_names_refseq": "MPTP; T cell protein-tyrosine phosphatase; protein-tyrosine phosphatase PTP-2; tyrosine-protein phosphatase non-receptor type 2 isoform b; tyrosine-protein phosphatase non-receptor type 2", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); pre-eclampsia (Disease Ontology:DOID:10591)", "pathway": " (mmu:19255); (R-MMU-6807004); (R-MMU-877312); (R-MMU-9833482)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11498795;11773439;11909529;12138178;1283199;14726372;14966296;15696169;16705167;17210636;1731319;20484139;21183079;21750661;22080863;22124607;26026268;28528544;31599954;38015772;38379221;38962170;9271584", "class_list": "", "function": "Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PTPN2 Regulates Metabolic Flux to Affect beta-Cell Susceptibility to Inflammatory Stress., [RefSeq, PubMed]; PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3., [RefSeq, PubMed]; Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated Attenuation of Experimental Colitis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V259;Q922E7", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;2.7.10.1;2.7.10.2;2.7.11.1;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0019905 syntaxin binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0070104 negative regulation of interleukin-6-mediated signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0010888 negative regulation of lipid storage;GO:0050922 negative regulation of chemotaxis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q06180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0EEE2-1", "uniprot_id": "PTHD3_MOUSE", "mass": 101813.0, "length": 906, "protein_name": "Patched domain-containing protein 3", "gene_name": "Ptchd3", "organism": "Mouse", "refseq_name": "patched domain-containing protein 3", "refseq_ac": "NP_083325", "gene_names_uniprotkb": "Ptchd3", "gene_names_refseq": "4930451E13Rik; 4933440L20Rik; Ptchd3; RNDEu-3", "protein_names_uniprotkb": "Patched domain-containing protein 3; RND-type protein RNDEu-3", "protein_names_refseq": "RND-type protein RNDEu-3; patched domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74675)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17904097;34428180;34493359", "class_list": "", "function": "May play a role in sperm development or sperm function (PubMed:17904097). However, does not appear to have an essential role in spermatogenesis or male fertility (PubMed:34493359)., [UniProtKB, PubMed, PubMed]; Mouse Ptchd3 is a non-essential gene., [RefSeq, PubMed]; Results indicate that Ptchd3 is a novel male germ cell-specific gene and may be involved in the Hh signaling to regulate sperm development and/or sperm function., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AC39;Q9CUM1;Q9D3R2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0097225 sperm midpiece", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0EEE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3LAC4-1", "uniprot_id": "PREX2_MOUSE", "mass": 181717.0, "length": 1598, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "gene_name": "Prex2", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 1", "refseq_ac": "NP_083801", "gene_names_uniprotkb": "Prex2; Depdc2", "gene_names_refseq": "6230420N16Rik; C030045D06Rik; D430013K02; Depdc2; P-Rex2; Prex2", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; DEP domain-containing protein 2; P-Rex2; PtdIns(3,4,5)-dependent Rac exchanger 2", "protein_names_refseq": "DEP domain containing 2; DEP domain-containing protein 2; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; ptdIns(3,4,5)-dependent Rac exchanger 2", "tax_id": 10090, "disease": "hepatitis B (Disease Ontology:DOID:2043); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); Klatskin's tumor (Disease Ontology:DOID:4927); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:109294); (R-MMU-8948751); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "15304343;18334636;20694145;21750661;27111337;34428180;35083941", "class_list": "", "function": "Complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators, [RefSeq, PubMed]; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity)., [UniProtKB]; P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function, [RefSeq, PubMed]; P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain., [RefSeq, PubMed]; PI3K/P-Rex/Rac pathway is required for late phase long-term potentiation in the mouse cerebellum Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMG3;Q3UQI2;Q3UU18;Q9CXD5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008344 adult locomotory behavior;GO:0032007 negative regulation of TOR signaling;GO:0048813 dendrite morphogenesis;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3LAC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UKY7-1", "uniprot_id": "PRS38_MOUSE", "mass": 35698.0, "length": 322, "protein_name": "Serine protease 38", "gene_name": "Prss38", "organism": "Mouse", "refseq_name": "serine protease 38 precursor", "refseq_ac": "NP_001038986", "gene_names_uniprotkb": "Prss38; Gm249; Mpn2", "gene_names_refseq": "Gm249; Mpn2; Prss38", "protein_names_uniprotkb": "Serine protease 38; 3.4.21.-; Marapsin-2", "protein_names_refseq": "marapsin-2; protease, serine 38; serine protease 38 precursor; serine protease MPN2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216797)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9EJM8", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UKY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UUY6-1", "uniprot_id": "PROM2_MOUSE", "mass": 93206.0, "length": 835, "protein_name": "Prominin-2", "gene_name": "Prom2", "organism": "Mouse", "refseq_name": "prominin-2 isoform 1 precursor", "refseq_ac": "NP_620089", "gene_names_uniprotkb": "Prom2; Proml2", "gene_names_refseq": "Prom-rp; Prom2", "protein_names_uniprotkb": "Prominin-2; PROM-2; Prominin-like protein 2; mPROML2", "protein_names_refseq": "PROM-2; mPROML2; prominin-2 isoform 1 precursor; prominin-like protein 2; prominin-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:192212)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12514187;17109118;17874118;18536929;20333396;37639200", "class_list": "", "function": "Data show the distribution and subcellular localization of prominin-2 within the kidney in situ., [RefSeq, PubMed]; Expression Prominin-2, in the three pairs of major salivary glands, i.e., submandibular-, major sublingual-, and parotid glands in adult mice., [RefSeq, PubMed]; Identification as well as molecular and cell biological characterization, [RefSeq, PubMed]; Prominin-2 is widely and abundantly expressed along the epithelia of various segments of the adult male genitourinary tract., [RefSeq, PubMed]; Regulation of tumorigenesis and ferroptosis in non-small cell lung cancer by a novel BBOX1-AS1/miR-326/PROM2 axis., [RefSeq, PubMed]; These data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AHT1;Q8CDM5;Q8CHT5;Q8R4Y7;Q9WUC7", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding", "go_cellular_component": "GO:0044393 microspike;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0001934 positive regulation of protein phosphorylation;GO:0032528 microvillus organization;GO:0031346 positive regulation of cell projection organization;GO:2001287 negative regulation of caveolin-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3UUY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q402U7-1", "uniprot_id": "PRS44_MOUSE", "mass": 41073.0, "length": 372, "protein_name": "Serine protease 44", "gene_name": "Prss44", "organism": "Mouse", "refseq_name": "serine protease 44 precursor", "refseq_ac": "NP_683742", "gene_names_uniprotkb": "Prss44; Tessp4", "gene_names_refseq": "1700036D21Rik; 79H19A; Prss44; TESSP-4; Tessp4", "protein_names_uniprotkb": "Serine protease 44; 3.4.21.-; TESSP-4; Testis serine protease 4; Testis-specific serine protease 4", "protein_names_refseq": "protease, serine 44; serine protease 44 precursor; serine protease-like 1; testis serine protease 4; testis specific serine protease 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:73336)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19798924;21750661;23536369;31403672", "class_list": "", "function": "Lacks protease activity in vitro., [UniProtKB, PubMed]; The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertilitydagger., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q924U6", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q402U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PRE5-1", "uniprot_id": "PRSR1_MOUSE", "mass": 91978.0, "length": 913, "protein_name": "Proline and serine-rich protein 1", "gene_name": "Proser1", "organism": "Mouse", "refseq_name": "proline and serine-rich protein 1", "refseq_ac": "NP_775558", "gene_names_uniprotkb": "Proser1", "gene_names_refseq": "2810046L04Rik; 9330161F11; Proser1", "protein_names_uniprotkb": "Proline and serine-rich protein 1", "protein_names_refseq": "proline and serine-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212127)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19144319;34678516;34887587;36852467;40885482", "class_list": "", "function": "Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGD1;Q6PFH9;Q80WX5;Q8BYT2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5PRE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SSW2-1", "uniprot_id": "PSME4_MOUSE", "mass": 211197.0, "length": 1843, "protein_name": "Proteasome activator complex subunit 4", "gene_name": "Psme4", "organism": "Mouse", "refseq_name": "proteasome activator complex subunit 4", "refseq_ac": "NP_598774", "gene_names_uniprotkb": "Psme4; Kiaa0077", "gene_names_refseq": "Blm10; Psme4; TEMO; mBlm10; mKIAA0077", "protein_names_uniprotkb": "Proteasome activator complex subunit 4; Blm10; Proteasome activator PA200; Protein BLM10 homolog; Protein TEMO; mBlm10", "protein_names_refseq": "proteasome activator PA200; proteasome activator complex subunit 4; protein BLM10 homolog", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)", "pathway": " (mmu:103554)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12093752;16581775;16857966;21750661;22645316;23706739;25428506;27802388;30084848;34428180;38320810;39627609", "class_list": "", "function": "Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks., [UniProtKB, PubMed, PubMed]; Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4IXU5;Q3TER7;Q3V2B7;Q6ZQJ7;Q7TMY9;Q8K0K0;Q99KM2;Q9ESY1", "ec_number_list": "", "go_molecular_function": "GO:0016504 peptidase activator activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010499 proteasomal ubiquitin-independent protein catabolic process;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5SSW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60866-1", "uniprot_id": "PTER_MOUSE", "mass": 39218.0, "length": 349, "protein_name": "N-acetyltaurine hydrolase", "gene_name": "Pter", "organism": "Mouse", "refseq_name": "N-acetyltaurine hydrolase isoform 3", "refseq_ac": "NP_001292365", "gene_names_uniprotkb": "Pter", "gene_names_refseq": "Mpr56-1; Pter", "protein_names_uniprotkb": "N-acetyltaurine hydrolase; 3.1.-.-; Parathion hydrolase-related protein; Phosphotriesterase-related protein", "protein_names_refseq": "N-acetyltaurine hydrolase isoform 3; N-acetyltaurine hydrolase; parathion hydrolase (phosphotriesterase)-related protein; phosphotriesterase-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19212)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;28135057;31219806;34428180;39112712;8654936", "class_list": "", "function": "N-acetyltaurine hydrolase that regulates feeding by catalyzing the hydrolysis of N-acetyltaurine into taurine and acetate (PubMed:39112712). N-acetyltaurine has anorexigenic and anti-obesity effects that are dependent on GFRAL receptor and GDF15 (PubMed:39112712). PTER also acts on other N-acetyl amino acids (Met, Ile, Leu, Val) and N-propionyltaurine, but at lower rates (PubMed:39112712)., [UniProtKB, PubMed]; PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUR4;A2AUR6;Q8BTA3", "ec_number_list": "3.1.-.-;3.5.1.14", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0141215 N-acetyltaurine hydrolase activity;GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0032098 regulation of appetite;GO:0019530 taurine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q60866-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62100-1", "uniprot_id": "PRM3_MOUSE", "mass": 11166.0, "length": 101, "protein_name": "Protamine-3", "gene_name": "Prm3", "organism": "Mouse", "refseq_name": "protamine-3", "refseq_ac": "NP_038666", "gene_names_uniprotkb": "Prm3", "gene_names_refseq": "PX; Prm3; Pxg", "protein_names_uniprotkb": "Protamine-3; Sperm protamine P3", "protein_names_refseq": "protamine-3; sperm protamine P3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19120)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18256328;20944085;8720108", "class_list": "", "function": "PRM3 is an acidic protein that is localized in the cytoplasm of elongated spermatids. Sperm from Prm3(-/-) males exhibited reductions in motility., [RefSeq, PubMed]; PRM3 shows several clear differences from other protamines, and it cannot be regarded as a true protamine. Among 10 mouse species, PRM3 showed weak evidence of positive selection in two species but no clear association with levels of sperm competition., [RefSeq, PubMed]; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMD8;Q5BKQ3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62100-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66GT5-1", "uniprot_id": "PTPM1_MOUSE", "mass": 21943.0, "length": 193, "protein_name": "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1", "gene_name": "Ptpmt1", "organism": "Mouse", "refseq_name": "phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1", "refseq_ac": "NP_079852", "gene_names_uniprotkb": "Ptpmt1; Plip", "gene_names_refseq": "1110001D10Rik; 2810004N20Rik; PLIP; Ptpmt1", "protein_names_uniprotkb": "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; 3.1.3.16; 3.1.3.27; 3.1.3.48; PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1", "protein_names_refseq": "PTEN-like phosphatase; phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; phosphoinositide lipid phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66461)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15247229;16039589;21641550;21730175;21750661;23806337;34428180;37672386", "class_list": "", "function": "Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (PubMed:21641550, PubMed:21730175). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed:21641550). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis, [RefSeq, PubMed]; PTPMT1 is targeted to the mitochondrion by an N-terminal signal sequence and is found anchored to the matrix face of the inner membrane. Knockdown of PTPMT1 in INS-1 832/13 cells enhances ATP production and insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSJ8;Q9D622", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.95;3.1.3.36;3.1.3.21;3.1.3.18;3.1.3.86", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008962 phosphatidylglycerophosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0102091 phosphatidylinositol-5-phosphate phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:2001242 regulation of intrinsic apoptotic signaling pathway;GO:0043653 mitochondrial fragmentation involved in apoptotic process;GO:0046488 phosphatidylinositol metabolic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q66GT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZK8-1", "uniprot_id": "PTPC1_MOUSE", "mass": 83934.0, "length": 747, "protein_name": "Protein tyrosine phosphatase domain-containing protein 1", "gene_name": "Ptpdc1", "organism": "Mouse", "refseq_name": "protein tyrosine phosphatase domain-containing protein 1 isoform 1", "refseq_ac": "NP_001288710", "gene_names_uniprotkb": "Ptpdc1", "gene_names_refseq": "Naa-1; Ptpcd1; Ptpdc1", "protein_names_uniprotkb": "Protein tyrosine phosphatase domain-containing protein 1; 3.1.3.-", "protein_names_refseq": "protein tyrosine phosphatase domain-containing protein 1 isoform 1; protein tyrosine phosphatase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:218232)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;19284988;21289087;21750661", "class_list": "", "function": "AW456874 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; May play roles in cilia formation and/or maintenance., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene is a centrosomal mitotic phosphatase. This protein has been implicated in centrosomal duplication and cytokinesis. In addition, knockdown of expression levels in non-cycling cells results in extra long cilia, suggesting that this protein may function in regulating cilia length independent of a function in cell cycle control. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]; These results suggested that Ptpcd1 is involved in centrosomal duplication and cytokinesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0Z6;Q3V3K9;Q3V3Y0;Q6NV81;Q8BKD9", "ec_number_list": "", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NZK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RUU0-1", "uniprot_id": "PTX4_MOUSE", "mass": 53150.0, "length": 478, "protein_name": "Pentraxin-4", "gene_name": "Ptx4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ptx4", "gene_names_refseq": "", "protein_names_uniprotkb": "Pentraxin-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:68509)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20357257;21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q08EL0;Q148B7;Q14BG6;Q9D1A3", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6RUU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VL3-1", "uniprot_id": "PRIC3_MOUSE", "mass": 69727.0, "length": 624, "protein_name": "Prickle planar cell polarity protein 3", "gene_name": "Prickle3", "organism": "Mouse", "refseq_name": "prickle planar cell polarity protein 3", "refseq_ac": "NP_001277553", "gene_names_uniprotkb": "Prickle3; Lmo6", "gene_names_refseq": "Lmo6; Pk3; Prickle3; Sfc16", "protein_names_uniprotkb": "Prickle planar cell polarity protein 3; LIM domain only protein 6; LMO-6; Pk3; Prickle-like protein 3; Triple LIM domain protein 6", "protein_names_refseq": "LIM domain only protein 6; prickle homolog 3; prickle planar cell polarity protein 3; prickle-like protein 3; triple LIM domain protein 6", "tax_id": 10090, "disease": "Leber plus disease (Disease Ontology:DOID:0111754)", "pathway": " (mmu:54630)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;32516135", "class_list": "", "function": "Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135)., [UniProtKB, UniProtKB, PubMed]; PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVA9;Q8CAY9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80VL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZC9-1", "uniprot_id": "PS1C2_MOUSE", "mass": 14414.0, "length": 134, "protein_name": "Psoriasis susceptibility 1 candidate gene 2 protein homolog", "gene_name": "Psors1c2", "organism": "Mouse", "refseq_name": "psoriasis susceptibility 1 candidate gene 2 protein homolog precursor", "refseq_ac": "NP_065601", "gene_names_uniprotkb": "Psors1c2; Spr1", "gene_names_refseq": "Pcg; Psors1c2; SPR1", "protein_names_uniprotkb": "Psoriasis susceptibility 1 candidate gene 2 protein homolog; Protein SPR1", "protein_names_refseq": "MHC psoriasis candidate; psoriasis susceptibility 1 candidate gene 2 protein homolog precursor; psoriasis susceptibility 1 candidate gene 2 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:57390)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12930300;15510217", "class_list": "", "function": "Spr1 is a gp130 pathway- and stress-inducible cardioprotective protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810F0-1", "uniprot_id": "PRIMA_MOUSE", "mass": 16564.0, "length": 153, "protein_name": "Proline-rich membrane anchor 1", "gene_name": "Prima1", "organism": "Mouse", "refseq_name": "proline-rich membrane anchor 1 precursor", "refseq_ac": "NP_579942", "gene_names_uniprotkb": "Prima1", "gene_names_refseq": "B230212M13Rik; PRiMA; Prima1", "protein_names_uniprotkb": "Proline-rich membrane anchor 1; PRiMA", "protein_names_refseq": "acetylcholinesterase membrane anchor; proline-rich membrane anchor 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:170952)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11804574;14622217;17158452;17324938;20147288;21750661;23861875;24612677", "class_list": "", "function": "A peptidic motif of PRiMA1 is defined which is nearly as efficient as the complete extracellular domain of PRiMA for recruitment of acetylcholinesterase subunits into secreted heteromeric complexes., [RefSeq, PubMed]; Elevated expression of muscarinic receptors is responsible for physiological adaptation of PRiMA-deficient developing mice. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of PRiMA, as well as PRiMA-associated G(4) AChE, in muscle is suppressed by muscle regulatory factors, muscular activity, and nerve-derived trophic factors, [RefSeq, PubMed]; It interacts with PS1 and undergoes proteolytic processing., [RefSeq, PubMed]; PRiMA expression is predominantly to the cholinergic system and that anchoring of cholinesterases to cell membranes by PRiMA represents a limiting factor for production of the AChE tailed splice variant (AChET)-PRiMA complex., [RefSeq, PubMed]; Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHC4", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0045202 synapse;GO:0070161 anchoring junction", "go_biological_process": "GO:0051649 establishment of localization in cell", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q810F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811G0-1", "uniprot_id": "PTHB1_MOUSE", "mass": 99057.0, "length": 885, "protein_name": "Protein PTHB1", "gene_name": "Bbs9", "organism": "Mouse", "refseq_name": "protein PTHB1 isoform 1", "refseq_ac": "NP_848502", "gene_names_uniprotkb": "Bbs9; Pthb1", "gene_names_refseq": "Bbs9; E130103I17Rik", "protein_names_uniprotkb": "Protein PTHB1; Bardet-Biedl syndrome 9 protein homolog; Parathyroid hormone-responsive B1 gene protein homolog", "protein_names_refseq": "EST 3159894; bardet-Biedl syndrome 9 protein homolog; parathyroid hormone-responsive B1 gene protein homolog; protein PTHB1 isoform 1; protein PTHB1", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 9 (Disease Ontology:DOID:0110131); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); craniosynostosis (Disease Ontology:DOID:2340); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:319845); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;22072986;34418053", "class_list": "", "function": "The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97498;Q3UMR2;Q7TQH9;Q8BKD7;Q8K0T5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0045444 fat cell differentiation;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q811G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP74-1", "uniprot_id": "PSTK_MOUSE", "mass": 40763.0, "length": 359, "protein_name": "L-seryl-tRNA(Sec) kinase", "gene_name": "Pstk", "organism": "Mouse", "refseq_name": "L-seryl-tRNA(Sec) kinase isoform 1", "refseq_ac": "NP_001034623", "gene_names_uniprotkb": "Pstk", "gene_names_refseq": "5430423O14Rik; 5730458D16Rik; Gm1099; Pstk", "protein_names_uniprotkb": "L-seryl-tRNA(Sec) kinase; 2.7.1.164; O-phosphoseryl-tRNA(Sec) kinase", "protein_names_refseq": "L-seryl-tRNA(Sec) kinase isoform 1; L-seryl-tRNA(Sec) kinase; O-phosphoseryl-tRNA(Sec) kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:214580)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15317934;17194211;21750661;25592138;28419530", "class_list": "", "function": "PSTK is a novel gene associated with early lung injury in Paraquat Poisoning., [RefSeq, PubMed]; Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (PubMed:15317934, PubMed:17194211). No activity with other tRNAs has been detected (PubMed:15317934)., [UniProtKB, PubMed, PubMed]; Study identified a set of candidate genes that are putatively regulated by PSTK in podocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0D2I7;Q14C09", "ec_number_list": "2.7.1.164", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0016301 kinase activity;GO:0043915 L-seryl-tRNA(Sec) kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0001514 selenocysteine incorporation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BP74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BW00-1", "uniprot_id": "PTH_MOUSE", "mass": 22161.0, "length": 204, "protein_name": "Probable peptidyl-tRNA hydrolase", "gene_name": "Ptrh1", "organism": "Mouse", "refseq_name": "probable peptidyl-tRNA hydrolase", "refseq_ac": "NP_848710", "gene_names_uniprotkb": "Ptrh1", "gene_names_refseq": "2210013M04Rik; PTH; Ptrh1", "protein_names_uniprotkb": "Probable peptidyl-tRNA hydrolase; 3.1.1.29; PTH", "protein_names_refseq": "probable peptidyl-tRNA hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:329384)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37434177", "class_list": "", "function": "High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment. Publication Status: Online-Only, [RefSeq, PubMed]; Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (By similarity). Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (By similarity). Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.29", "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0072344 rescue of stalled ribosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BW00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0F9-1", "uniprot_id": "PRS35_MOUSE", "mass": 45787.0, "length": 409, "protein_name": "Inactive serine protease 35", "gene_name": "Prss35", "organism": "Mouse", "refseq_name": "inactive serine protease 35 precursor", "refseq_ac": "NP_848853", "gene_names_uniprotkb": "Prss35", "gene_names_refseq": "6030424L22Rik; P3D9; Prss35", "protein_names_uniprotkb": "Inactive serine protease 35", "protein_names_refseq": "inactive serine protease 35 precursor; inactive serine protease 35; protease, serine 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:244954)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16870946;18566130;20173027;38157023", "class_list": "", "function": "HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia, [RefSeq, PubMed]; Prss35 mRNA levels increased around the time of ovulation and remained elevated in the developing corpus luteum GeneRIF: Mouse ortholog of human PRSS35 is an ovary-selectively expressed gene., [RefSeq, PubMed]; Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0D6;Q8C0L5", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C0F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2Z2-1", "uniprot_id": "PRP39_MOUSE", "mass": 77921.0, "length": 665, "protein_name": "Pre-mRNA-processing factor 39", "gene_name": "Prpf39", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prpf39", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre-mRNA-processing factor 39; PRP39 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;37507081", "class_list": "", "function": "Involved in pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1I4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000395 mRNA 5'-splice site recognition;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K2Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R107-1", "uniprot_id": "PRLD1_MOUSE", "mass": 24960.0, "length": 217, "protein_name": "PRELI domain-containing protein 1, mitochondrial", "gene_name": "Prelid1", "organism": "Mouse", "refseq_name": "PRELI domain-containing protein 1, mitochondrial precursor", "refseq_ac": "NP_079872", "gene_names_uniprotkb": "Prelid1; Preli", "gene_names_refseq": "2610524G07Rik; Prelid1; Preli", "protein_names_uniprotkb": "PRELI domain-containing protein 1, mitochondrial; Px19-like protein", "protein_names_refseq": "PRELI domain-containing protein 1, mitochondrial precursor; PRELI domain-containing protein 1, mitochondrial; PX19 homolog; protein of relevant evolutionary and lymphoid interest; px19-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66494); (R-MMU-6803204)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14640972;21364629;22666421;30059200;34428180", "class_list": "", "function": "Identification of PRELI (protein of relevant evolutionary and lymphoid interest) which encodes a mitochondrial protein and is located on a conserved gene cluster on chromosome 5., [RefSeq, PubMed]; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity)., [UniProtKB, PubMed, UniProtKB]; PRELI interacts with OPA1 to maintain mitochondria structures intact, sustain balanced ion(-)/proton(+) gradients, promote oxidative phosphorylation reactions, regulate pro- and antiapoptotic protein traffic and enable cell responses to induced death., [RefSeq, PubMed]; PRELI is a vital LEA B cell protein with failsafe genetics, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCN0;Q4QQJ9;Q6PCZ5;Q78IE2;Q9D1F7", "ec_number_list": "1.6.5.5", "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0051881 regulation of mitochondrial membrane potential;GO:0015914 phospholipid transport;GO:0045580 regulation of T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R107-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3K3-1", "uniprot_id": "PTCD2_MOUSE", "mass": 43844.0, "length": 381, "protein_name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "gene_name": "Ptcd2", "organism": "Mouse", "refseq_name": "pentatricopeptide repeat-containing protein 2, mitochondrial", "refseq_ac": "NP_081149", "gene_names_uniprotkb": "Ptcd2", "gene_names_refseq": "1190005P08Rik; Ptcd2", "protein_names_uniprotkb": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "protein_names_refseq": "pentatricopeptide repeat-containing protein 2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68927)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18729827;25428506;30084848;30779550;31599954;33649389;34428180;35820727", "class_list": "", "function": "Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function., [UniProtKB, PubMed]; PTCD2 protein is involved in processing RNA transcripts involving cytochrome b derived from mitochondrial DNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VG3;Q9D0S7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0001889 liver development;GO:0006397 mRNA processing;GO:0007507 heart development;GO:0001822 kidney development;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R3K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920S2-1", "uniprot_id": "PRS41_MOUSE", "mass": 36218.0, "length": 322, "protein_name": "Serine protease 41", "gene_name": "Prss41", "organism": "Mouse", "refseq_name": "serine protease 41 isoform 1 precursor", "refseq_ac": "NP_081920", "gene_names_uniprotkb": "Prss41; Tessp1", "gene_names_refseq": "4931440B09Rik; Prss41; Tessp-1; Tessp1", "protein_names_uniprotkb": "Serine protease 41; 3.4.21.-; TESSP-1; Testis serine protease 1", "protein_names_refseq": "protease, serine 41; serine protease 41 isoform 1 precursor; testis serine protease 1; testis-specific serine protease 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71003); (R-MMU-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15515062;19798924;23536369;24129193", "class_list": "", "function": "A novel type of serine protease, designated testis-specific serine protease 1 (TESSP-1), from the adult mouse testis was cloned., [RefSeq, PubMed]; The Prss/Tessp proteases are important for the progression of meiosis at each stage., [RefSeq, PubMed]; The results of this study suggest that TESSP1 is predominantly localized in the plasma membrane of spermatogonia and Sertoli cells in the basal compartment., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX01", "ec_number_list": "3.4.11.9;3.1.3.1;3.1.4.50;3.9.1.1;3.2.2.6;3.4.17.12;2.4.2.31;3.4.21.-;3.5.1.92", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043229 intracellular organelle;GO:0098552 side of membrane", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q920S2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWH6-1", "uniprot_id": "PSMA8_MOUSE", "mass": 27866.0, "length": 250, "protein_name": "Proteasome subunit alpha type-8", "gene_name": "Psma8", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-8 isoform 1", "refseq_ac": "NP_001157081", "gene_names_uniprotkb": "Psma8; Psma7l", "gene_names_refseq": "2410072D24Rik; Psma8", "protein_names_uniprotkb": "Proteasome subunit alpha type-8; Alpha4s; Proteasome alpha 4 subunit; Proteasome subunit alpha-type 7-like", "protein_names_refseq": "alpha4s; proteasome (prosome, macropain) subunit, alpha type, 8; proteasome alpha 4 subunit; proteasome alpha 8 subunit; proteasome subunit alpha type-8 isoform 1; proteasome subunit alpha type-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:73677)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23706739;31358751;31437213;34428180", "class_list": "", "function": "Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis (PubMed:23706739, PubMed:31358751, PubMed:31437213). The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds (Probable). Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis (PubMed:31358751). Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I (PubMed:31437213)., [UniProtKB, PubMed, PubMed, PubMed]; Meiosis I progression in spermatogenesis, particularly entry into and exit from M-phase, requires the proteasomal activity of proteasome subunit alpha 8 (PSMA8)-associated proteasomes. Publication Status: Online-Only, [RefSeq, PubMed]; Study in mouse model shows that Psma8 is localized to and dependent on the central element of the synaptonemal complex and promotes the assembly of the proteasome activator PA200. Accordingly, synapsis-deficient mice show delocalization of Psma8. Loss of Psma8 leads to infertility in males. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14A44", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWJ9-1", "uniprot_id": "PUR9_MOUSE", "mass": 64217.0, "length": 592, "protein_name": "Bifunctional purine biosynthesis protein ATIC", "gene_name": "Atic", "organism": "Mouse", "refseq_name": "bifunctional purine biosynthesis protein ATIC", "refseq_ac": "NP_080471", "gene_names_uniprotkb": "Atic; Purh", "gene_names_refseq": "2610509C24Rik; Atic", "protein_names_uniprotkb": "Bifunctional purine biosynthesis protein ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR formyltransferase; AICAR transformylase/inosine monophosphate cyclohydrolase; AICAR transformylase; ATIC; IMP synthase; Inosinicase", "protein_names_refseq": "AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein ATIC; bifunctional purine biosynthesis protein PURH", "tax_id": 10090, "disease": "purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (mmu:108147); (R-MMU-73817)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "25428506;29072452;31219806;31599954;34428180;37453647;37507081;37828378;39627609;39927985", "class_list": "", "function": "Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:29072452). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:29072452). Also displays cyclohydrolase activity involving the cyclization of FAICAR to inosine monophosphate (IMP). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTQ3;Q80UH0;Q8BPF0;Q8BQV9;Q9CRI1;Q9CZW9", "ec_number_list": "2.1.2.3;3.5.4.10", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003937 IMP cyclohydrolase activity;GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0003360 brainstem development;GO:0046654 tetrahydrofolate biosynthetic process;GO:0021987 cerebral cortex development;GO:0031100 animal organ regeneration;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CWJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1T5-1", "uniprot_id": "PRR15_MOUSE", "mass": 13655.0, "length": 122, "protein_name": "Proline-rich protein 15", "gene_name": "Prr15", "organism": "Mouse", "refseq_name": "proline-rich protein 15", "refseq_ac": "NP_084300", "gene_names_uniprotkb": "Prr15; G90", "gene_names_refseq": "E130201N16Rik; G90; Prr15", "protein_names_uniprotkb": "Proline-rich protein 15", "protein_names_refseq": "proline-rich protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:78004)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10333519;12768423;21183079;37072408", "class_list": "", "function": "G90 expression and absence of proliferation were correlated in most of the cells showing expression of this gene during embryonic development in mice., [RefSeq, PubMed]; May have a role in proliferation and/or differentiation., [UniProtKB, PubMed]; PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D1T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D820-1", "uniprot_id": "PRXD1_MOUSE", "mass": 18862.0, "length": 169, "protein_name": "Prolyl-tRNA synthetase associated domain-containing protein 1", "gene_name": "Prorsd1", "organism": "Mouse", "refseq_name": "prolyl-tRNA synthetase associated domain-containing protein 1 isoform 1", "refseq_ac": "NP_001156926", "gene_names_uniprotkb": "Prorsd1; Prdxdd1", "gene_names_refseq": "2010316F05Rik; Ncrna00117; Prdxdd1; Prorsd1", "protein_names_uniprotkb": "Prolyl-tRNA synthetase associated domain-containing protein 1; PrdX deacylase domain-containing protein 1", "protein_names_refseq": "PrdX-deacylase domain 1; prdX deacylase domain-containing protein 1; prolyl-tRNA synthetase associated domain-containing protein 1 isoform 1; prolyl-tRNA synthetase associated domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67939)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25605945;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFX7", "ec_number_list": "", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D820-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9A7-1", "uniprot_id": "PTG3L_MOUSE", "mass": 15652.0, "length": 131, "protein_name": "Putative protein PTGES3L", "gene_name": "Ptges3l", "organism": "Mouse", "refseq_name": "putative protein PTGES3L isoform 2", "refseq_ac": "NP_081141", "gene_names_uniprotkb": "Ptges3l", "gene_names_refseq": "1110069E20Rik; 1700113I22Rik; Ptges3l", "protein_names_uniprotkb": "Putative protein PTGES3L; Prostaglandin E synthase 3-like", "protein_names_refseq": "alanyl-tRNA synthetase domain containing 1; prostaglandin E synthase 3 (cytosolic)-like; putative protein PTGES3L isoform 2; putative protein PTGES3L", "tax_id": 10090, "disease": "", "pathway": " (mmu:73635)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0U4", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JM51-1", "uniprot_id": "PTGES_MOUSE", "mass": 17286.0, "length": 153, "protein_name": "Prostaglandin E synthase", "gene_name": "Ptges", "organism": "Mouse", "refseq_name": "prostaglandin E synthase", "refseq_ac": "NP_071860", "gene_names_uniprotkb": "Ptges; Pges", "gene_names_refseq": "2410099E23Rik; D2Ertd369e; Pges; Ptges; mPGES-1; mPGES", "protein_names_uniprotkb": "Prostaglandin E synthase; 1.11.1.-; 2.5.1.18; 5.3.99.3; Glutathione peroxidase PTGES; Glutathione transferase PTGES; Microsomal prostaglandin E synthase 1; mPGES-1", "protein_names_refseq": "glutathione peroxidase PTGES; glutathione transferase PTGES; microsomal prostaglandin E synthase 1; prostaglandin E synthase", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); penile benign neoplasm (Disease Ontology:DOID:11624); peptic esophagitis (Disease Ontology:DOID:13976); ovary epithelial cancer (Disease Ontology:DOID:2152); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometriosis (Disease Ontology:DOID:289); ischemia (Disease Ontology:DOID:326); lung non-small cell carcinoma (Disease Ontology:DOID:3908); in situ carcinoma (Disease Ontology:DOID:8719); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:64292); (R-MMU-2162123)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10869354;11704570;11795891;12835414;14566340;25428506;30084848", "class_list": "", "function": "Localization of membrane form in the urogenital tract, [RefSeq, PubMed]; Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway (PubMed:10869354, PubMed:11795891). Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10869354, PubMed:11795891). Plays a key role in inflammation response, fever and pain (PubMed:12835414, PubMed:14566340). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9C5", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.11.1.12;1.11.1.9;5.3.99.3;2.5.1.-", "go_molecular_function": "GO:0004667 prostaglandin-D synthase activity;GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0050220 prostaglandin-E synthase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0031620 regulation of fever generation;GO:0008285 negative regulation of cell population proliferation;GO:0019233 sensory perception of pain;GO:0050727 regulation of inflammatory response;GO:0006693 prostaglandin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JM51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX98-1", "uniprot_id": "PTF1A_MOUSE", "mass": 35185.0, "length": 324, "protein_name": "Pancreas transcription factor 1 subunit alpha", "gene_name": "Ptf1a", "organism": "Mouse", "refseq_name": "pancreas transcription factor 1 subunit alpha", "refseq_ac": "NP_061279", "gene_names_uniprotkb": "Ptf1a; Ptf1p48", "gene_names_refseq": "PTF1-p48; PTF1p48; Ptf1a; bHLHa29", "protein_names_uniprotkb": "Pancreas transcription factor 1 subunit alpha; PTF1-p48; Pancreas-specific transcription factor 1a; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1", "protein_names_refseq": "bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; pancreas transcription factor 1 subunit alpha; pancreas transcription factor1 p48 subunit", "tax_id": 10090, "disease": "pancreatic agenesis 2 (Disease Ontology:DOID:0060988)", "pathway": " (mmu:19213)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11318877;11562365;12185368;15543146;17075007;21852532;23437001;9851981", "class_list": "", "function": "The Sd heterozygote phenotype was not ameliorated by Ptf1a haploinsufficiency, further suggesting that the developmental defects result from ectopic expression of Ptf1a., [RefSeq, PubMed]; Transcription factor implicated in the cell fate determination in various organs (PubMed:11562365, PubMed:12185368, PubMed:15543146, PubMed:17075007, PubMed:9851981). Binds to the E-box consensus sequence 5'-CANNTG-3' (PubMed:11562365, PubMed:12185368, PubMed:9851981). Plays a role in early and late pancreas development and differentiation (PubMed:11562365, PubMed:21852532). Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates (PubMed:11562365, PubMed:12185368, PubMed:9851981). May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase (PubMed:11562365, PubMed:12185368, PubMed:9851981). Required for the formation of pancreatic acinar and ductal cells (PubMed:11562365). Plays an important role in cerebellar development (PubMed:15543146). Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates (PubMed:17075007)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYF5;Q9QYF6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0061074 regulation of neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QX98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z211-1", "uniprot_id": "PX11A_MOUSE", "mass": 28153.0, "length": 246, "protein_name": "Peroxisomal membrane protein 11A", "gene_name": "Pex11a", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein 11A", "refseq_ac": "NP_035198", "gene_names_uniprotkb": "Pex11a", "gene_names_refseq": "PEX11alpha; Pex11a", "protein_names_uniprotkb": "Peroxisomal membrane protein 11A; PEX11-alpha; Peroxin-11A; Peroxisomal biogenesis factor 11A; Protein PEX11 homolog alpha", "protein_names_refseq": "PEX11-alpha; peroxin-11A; peroxisomal biogenesis factor 11a; peroxisomal membrane protein 11A; protein PEX11 homolog alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:18631)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12417726;23169785;25113963;34428180;37453647;9792670", "class_list": "", "function": "May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions., [RefSeq, PubMed]; Pex11alpha deficiency impairs peroxisome elongation and abundance and peroxisomal fatty acid oxidation, which contributes to increased lipid accumulation in the liver., [RefSeq, PubMed]; Required for peroxisome proliferation in response to 4-phenylbutyrate but dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5B8", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0016559 peroxisome fission;GO:0050873 brown fat cell differentiation;GO:0007031 peroxisome organization;GO:0016557 peroxisome membrane biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88413-1", "uniprot_id": "TULP3_MOUSE", "mass": 51231.0, "length": 460, "protein_name": "Tubby-related protein 3", "gene_name": "Tulp3", "organism": "Mouse", "refseq_name": "tubby-related protein 3", "refseq_ac": "NP_035787", "gene_names_uniprotkb": "Tulp3", "gene_names_refseq": "2310022L06Rik; Tulp3", "protein_names_uniprotkb": "Tubby-related protein 3; Protein hitchhiker; Tubby-like protein 3; hhkr", "protein_names_refseq": "tubby-like protein 3; tubby-related protein 3", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); polycystic kidney disease (Disease Ontology:DOID:0080322); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22158); (R-MMU-5610787)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11406614;19223390;19286674;19334287;19695251;21209331;21750661;25428506;30084848;31761534;34346313;35820727;39695235;40472089;9828123", "class_list": "", "function": "Protein-protein adapter that drives transport of G protein-coupled receptors into primary cilia by mediating association between the intraflagellar transport complex A (IFT-A) and G protein-coupled receptors FFAR4, GPR45 and GPR161 (PubMed:19286674, PubMed:19334287, PubMed:31761534, PubMed:34346313, PubMed:40472089). Acts as a negative regulator of the Shh signaling by promoting trafficking of GPR161 to cilia (PubMed:19223390, PubMed:19286674, PubMed:19334287, PubMed:34346313). During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes (PubMed:31761534). Promotes transport of GPR45 into primary cilia of neurons in paraventricular nucleus (PVN) of the hypothalamus (PubMed:40472089). Binds to phosphorylated inositide (phosphoinositide) lipids; both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking (By similarity). Besides its role in cilium localization, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds lithocholic acid, a metabolite generated in response to calorie restriction, promoting TULP3 ability to activate SIRT1, which then deacetylates the ATP6V1E1 subunit of the V-ATPase complex, leading to (1) V-ATPase complex inhibition on lysosomes and (2) AMPK activation via the AXIN1-STK11/LKB1 axis (PubMed:39695235)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Tulp3 is a novel negative regulator of the Shh pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0001664 G protein-coupled receptor binding;GO:0044877 protein-containing complex binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007420 brain development;GO:0001843 neural tube closure;GO:0009952 anterior/posterior pattern specification;GO:0021915 neural tube development;GO:0031076 embryonic camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88413-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13438-1", "uniprot_id": "TSP_MOUSE", "mass": 13948.0, "length": 124, "protein_name": "Trophoblast-specific protein alpha", "gene_name": "Tpbpa", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tpbpa; Tpbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Trophoblast-specific protein alpha", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;3215514", "class_list": "", "function": "It may be a growth factor/hormone, perhaps involved in interaction between the maternal and fetal systems in maintenance of pregnancy., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P13438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0PJN4-1", "uniprot_id": "U2QL1_MOUSE", "mass": 18364.0, "length": 161, "protein_name": "Ubiquitin-conjugating enzyme E2Q-like protein 1", "gene_name": "Ube2ql1", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2Q-like protein 1", "refseq_ac": "NP_001138634", "gene_names_uniprotkb": "Ube2ql1", "gene_names_refseq": "3110006E14Rik; Ube2ql1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2Q-like protein 1; 2.3.2.23; E2Q-like ubiquitin-conjugating enzyme 1", "protein_names_refseq": "E2Q-like ubiquitin-conjugating enzyme 1; ubiquitin-conjugating enzyme E2Q-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76980)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDR7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0PJN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ACP1-1", "uniprot_id": "TT39A_MOUSE", "mass": 66126.0, "length": 578, "protein_name": "Tetratricopeptide repeat protein 39A", "gene_name": "Ttc39a", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 39A isoform 1", "refseq_ac": "NP_001139420", "gene_names_uniprotkb": "Ttc39a; Kiaa0452", "gene_names_refseq": "4922503N01Rik; Ttc39a", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 39A; TPR repeat protein 39A", "protein_names_refseq": "TPR repeat protein 39A; tetratricopeptide repeat protein 39A isoform 1; tetratricopeptide repeat protein 39A", "tax_id": 10090, "disease": "", "pathway": " (mmu:230603)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACN9;A2ACP2;A2ACP3;A2ACP4;Q6A067;Q8C612;Q8CFL5;Q8K1A9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ACP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RSX7-1", "uniprot_id": "TYW5_MOUSE", "mass": 36633.0, "length": 315, "protein_name": "tRNA wybutosine-synthesizing protein 5", "gene_name": "Tyw5", "organism": "Mouse", "refseq_name": "tRNA wybutosine-synthesizing protein 5 isoform 1", "refseq_ac": "NP_001032831", "gene_names_uniprotkb": "Tyw5; 1110034B05Rik", "gene_names_refseq": "1110034B05Rik; Tyw5", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 5; 1.14.11.42; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase", "protein_names_refseq": "jmjC domain-containing protein C2orf60 homolog; tRNA wybutosine-synthesizing protein 5 isoform 1; tRNA wybutosine-synthesizing protein 5; tRNA yW-synthesizing enzyme 5; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68736)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25605945;30084848;30779550;31219806;34428180", "class_list": "", "function": "tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT82;Q4KL17", "ec_number_list": "1.14.11.42", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding;GO:0102524 tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", "go_cellular_component": "", "go_biological_process": "GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2RSX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KMP2-1", "uniprot_id": "TTC38_MOUSE", "mass": 52224.0, "length": 465, "protein_name": "Tetratricopeptide repeat protein 38", "gene_name": "Ttc38", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 38 isoform 1", "refseq_ac": "NP_001028509", "gene_names_uniprotkb": "Ttc38", "gene_names_refseq": "9030019H09; Ttc38", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 38; TPR repeat protein 38", "protein_names_refseq": "TPR repeat protein 38; tetratricopeptide repeat protein 38 isoform 1; tetratricopeptide repeat protein 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:239570)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05C02;Q05CK3;Q3UZU5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KMP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4Q9E4-1", "uniprot_id": "TTLL2_MOUSE", "mass": 62109.0, "length": 540, "protein_name": "Probable tubulin polyglutamylase TTLL2", "gene_name": "Ttll2", "organism": "Mouse", "refseq_name": "probable tubulin polyglutamylase TTLL2", "refseq_ac": "NP_001091737", "gene_names_uniprotkb": "Ttll2", "gene_names_refseq": "EG625850; Ttll2", "protein_names_uniprotkb": "Probable tubulin polyglutamylase TTLL2; 6.-.-.-; Tubulin--tyrosine ligase-like protein 2", "protein_names_refseq": "probable tubulin polyglutamylase TTLL2; putative polyglutamylase; tubulin--tyrosine ligase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100216474); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17499049", "class_list": "", "function": "Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (PubMed:17499049). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (By similarity). Probably involved in the side-chain initiation step of the polyglutamylation reaction rather than the elongation step (Probable)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.2.-;6.-.-.-;3.6.5.-", "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0036064 ciliary basal body", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4Q9E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4Q9E5-1", "uniprot_id": "TTLL3_MOUSE", "mass": 104428.0, "length": 927, "protein_name": "Tubulin monoglycylase TTLL3", "gene_name": "Ttll3", "organism": "Mouse", "refseq_name": "tubulin monoglycylase TTLL3 isoform 2", "refseq_ac": "NP_001136204", "gene_names_uniprotkb": "Ttll3", "gene_names_refseq": "4833441J24Rik; Ttll3", "protein_names_uniprotkb": "Tubulin monoglycylase TTLL3; 6.3.2.-; Tubulin--tyrosine ligase-like protein 3", "protein_names_refseq": "TTL domain protein; tubulin monoglycylase TTLL3 isoform 2; tubulin monoglycylase TTLL3; tubulin--tyrosine ligase-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:101100); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17499049;19524510;21750661;23897886;25180231;33414192;35822049", "class_list": "", "function": "Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin (PubMed:19524510). Not involved in elongation step of the polyglycylation reaction (PubMed:19524510). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (PubMed:33414192). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (PubMed:23897886, PubMed:25180231). Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development (PubMed:25180231). Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (PubMed:33414192)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The TTLL3 was required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was necessary for coordinated beating behavior., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BV51;Q8C0Y7;Q8VDS2", "ec_number_list": "6.3.2.-;3.6.5.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0070735 protein-glycine ligase activity;GO:0070736 protein-glycine ligase activity, initiating", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0035082 axoneme assembly;GO:0018094 protein polyglycylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A4Q9E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4Q9F1-1", "uniprot_id": "TTLL8_MOUSE", "mass": 94915.0, "length": 832, "protein_name": "Protein monoglycylase TTLL8", "gene_name": "Ttll8", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ttll8", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein monoglycylase TTLL8; 6.3.2.-; Tubulin--tyrosine ligase-like protein 8", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:239591); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17499049;19427864;19524510;21750661;23897886;25180231;28576883;33414192", "class_list": "", "function": "Monoglycylase which modifies both tubulin and non-tubulin proteins, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of target proteins (PubMed:19524510, PubMed:28576883). Not involved in elongation step of the polyglycylation reaction (PubMed:19524510). Preferentially monoglycylates alpha-tubulin over beta-tubulin (PubMed:19524510). Together with TTLL3, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (PubMed:19524510, PubMed:23897886, PubMed:25180231). Together with TTLL3, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (PubMed:33414192). Monoglycylates non-tubulin proteins such as ANP32A, ANP32B, SET, NCL and NAP1 (PubMed:19427864, PubMed:19524510)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14B76;Q8C0N7", "ec_number_list": "6.3.2.-;3.6.5.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0070735 protein-glycine ligase activity;GO:0070736 protein-glycine ligase activity, initiating;GO:0016874 ligase activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A4Q9F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H6E9-1", "uniprot_id": "TT23L_MOUSE", "mass": 51532.0, "length": 458, "protein_name": "Tetratricopeptide repeat protein 23-like", "gene_name": "Ttc23l", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 23-like isoform 1", "refseq_ac": "NP_083706", "gene_names_uniprotkb": "Ttc23l", "gene_names_refseq": "4930401A09Rik; Ttc23l", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 23-like", "protein_names_refseq": "Tetratricopeptide repeat protein 23-like; tetratricopeptide repeat protein 23-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75777)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;33300544", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMM7;Q9D5Q3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0030496 midbody", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A6H6E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AQJ2-1", "uniprot_id": "UBP36_MOUSE", "mass": 119913.0, "length": 1098, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 36", "gene_name": "Usp36", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 36", "refseq_ac": "NP_001028700", "gene_names_uniprotkb": "Usp36; Kiaa1453", "gene_names_refseq": "2700002L06Rik; Usp36; mKIAA1453", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 36; 2.3.2.-; 3.4.19.12; Deubiquitinating enzyme 36; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36", "protein_names_refseq": "deubiquitinating enzyme 36; ubiquitin carboxyl-terminal hydrolase 36; ubiquitin specific protease 36; ubiquitin thioesterase 36; ubiquitin-specific-processing protease 36", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:72344)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20485683;21750661;24788674;25428506;27445338;28135057;28528544;29273634;30084848;31599954", "class_list": "", "function": "Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability (PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (By similarity). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (By similarity). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (By similarity). Deubiquitinates SOD2, regulates SOD2 protein stability (By similarity). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (By similarity). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (By similarity). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (By similarity). Binds to pre-rRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed]; USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation., [RefSeq, PubMed]; Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPQ7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0016740 transferase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0140936 histone H2B deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007000 nucleolus organization;GO:2000232 regulation of rRNA processing;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "B1AQJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2B9E1-1", "uniprot_id": "TRIQK_MOUSE", "mass": 9722.0, "length": 86, "protein_name": "Triple QxxK/R motif-containing protein", "gene_name": "Triqk", "organism": "Mouse", "refseq_name": "triple QxxK/R motif-containing protein", "refseq_ac": "NP_001165272", "gene_names_uniprotkb": "Triqk; Gm11818", "gene_names_refseq": "C130086A10; Gm11818; Triqk", "protein_names_uniprotkb": "Triple QxxK/R motif-containing protein; Triple repetitive-sequence of QXXK/R protein homolog", "protein_names_refseq": "protein TRIQK; triple QxxK/R motif-containing protein; triple repetitive-sequence of QXXK/R protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:208820)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18828657", "class_list": "", "function": "May play a role in cell growth and maintenance of cell morphology., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2B9E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7ZNG4-1", "uniprot_id": "TROAP_MOUSE", "mass": 71959.0, "length": 668, "protein_name": "Tastin", "gene_name": "Troap", "organism": "Mouse", "refseq_name": "tastin", "refseq_ac": "NP_001155978", "gene_names_uniprotkb": "Troap", "gene_names_refseq": "E130301L11Rik; Troap; tastin", "protein_names_uniprotkb": "Tastin; Troap protein; Trophinin-assisting protein; Trophinin-associated protein", "protein_names_refseq": "tastin; trophinin-assisting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78733)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497S4;Q8BWP3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B7ZNG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55060-1", "uniprot_id": "TPMT_MOUSE", "mass": 27586.0, "length": 240, "protein_name": "Thiopurine S-methyltransferase", "gene_name": "Tpmt", "organism": "Mouse", "refseq_name": "thiopurine S-methyltransferase", "refseq_ac": "NP_058065", "gene_names_uniprotkb": "Tpmt", "gene_names_refseq": "Tpmt", "protein_names_uniprotkb": "Thiopurine S-methyltransferase; 2.1.1.67; Thiopurine methyltransferase", "protein_names_refseq": "thiopurine S-methyltransferase", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); poor metabolism of thiopurines 1 (Disease Ontology:DOID:0061004); poor metabolism of thiopurines (Disease Ontology:DOID:0080172); leukopenia (Disease Ontology:DOID:615); alopecia (Disease Ontology:DOID:987); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:22017); (R-MMU-156581); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15083069;18484748;21183079;21750661;28406961;35538648;9539138", "class_list": "", "function": "Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase., [RefSeq, PubMed]; Suggestion that differential mouse TPMT activity is due to variation in mRNA expression, [RefSeq, PubMed]; With the significant mitigation of TPMT wild type-expressing cells to cisplatin cytotoxicity, findings demonstrate a drug-gene interaction between increased TPMT activity and decreased susceptibility to cisplatin-induced toxicity of inner ear cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIL7;Q9QUG7", "ec_number_list": "2.1.1.67", "go_molecular_function": "GO:0008119 thiopurine S-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PVB5-1", "uniprot_id": "TTC17_MOUSE", "mass": 135521.0, "length": 1198, "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "Ttc17", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 17 isoform 1 precursor", "refseq_ac": "NP_898929", "gene_names_uniprotkb": "Ttc17", "gene_names_refseq": "9130020K17Rik; D2Bwg1005e; Ttc17", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 17; TPR repeat protein 17", "protein_names_refseq": "TPR repeat protein 17; tetratricopeptide repeat protein 17 isoform 1 precursor; tetratricopeptide repeat protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:74569)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;34428180", "class_list": "", "function": "Plays a role in primary ciliogenesis by modulating actin polymerization., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBE5;Q5RKR1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "E9PVB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0HA38-1", "uniprot_id": "TT21B_MOUSE", "mass": 150795.0, "length": 1315, "protein_name": "Tetratricopeptide repeat protein 21B", "gene_name": "Ttc21b", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 21B isoform a", "refseq_ac": "NP_001041069", "gene_names_uniprotkb": "Ttc21b; Ift139; Kiaa1992; Thm1", "gene_names_refseq": "2410066K11Rik; Thm1; Ttc21b; aln; mKIAA1992", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 21B; Intraflagellar transport 139 homolog; TPR repeat protein 21B; Tetratricopeptide repeat-containing hedgehog modulator 1", "protein_names_refseq": "TPR repeat protein 21B; intraflagellar transport 139 homolog; line 158; tetratricopeptide repeat protein 21B isoform a; tetratricopeptide repeat protein 21B; tetratricopeptide repeat-containing hedgehog modulator 1", "tax_id": 10090, "disease": "asphyxiating thoracic dystrophy 4 (Disease Ontology:DOID:0110088); nephronophthisis 12 (Disease Ontology:DOID:0111119); nephronophthisis (Disease Ontology:DOID:12712); cystic kidney disease (Disease Ontology:DOID:2975)", "pathway": " (mmu:73668); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18327258;19732765;21750661;21952136;22645316;25605945;25860617;30084848;33900625;34428180;35644283", "class_list": "", "function": "Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (By similarity). Negatively modulates the SHH signal transduction (PubMed:18327258)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data characterize the forebrain phenotype caused by loss of Ttc21b, a gene we identified in an ENU mutagenesis screen as a novel ciliary gene required for retrograde intraflagellar transport., [RefSeq, PubMed]; IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease., [RefSeq, PubMed]; Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner. Erratum:[Kidney Int. 2023 Feb;103(2):429. doi: 10.1016/j.kint.2022.11.015. PMID: 36681463], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, 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"reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0042101 T cell receptor complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07146-1", "uniprot_id": "TRY2_MOUSE", "mass": 26204.0, "length": 246, "protein_name": "Anionic trypsin-2", "gene_name": "Prss2", "organism": "Mouse", "refseq_name": "anionic trypsin-2 precursor", "refseq_ac": "NP_033456", "gene_names_uniprotkb": "Prss2; Try2", "gene_names_refseq": "Prss2; TRY8; TRYP; Ta; Tesp4; Try2", "protein_names_uniprotkb": "Anionic trypsin-2; 3.4.21.4; Anionic trypsin II; Pretrypsinogen II; Serine protease 2", "protein_names_refseq": "anionic trypsin II; anionic trypsin-2 precursor; anionic trypsin-2; pretrypsinogen II; protease, serine 2; trypsin 2; trypsinogen 20", "tax_id": 10090, "disease": "cystic fibrosis (Disease Ontology:DOID:1485); cholangiocarcinoma (Disease Ontology:DOID:4947); pancreatitis (Disease Ontology:DOID:4989); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:22072); (R-MMU-1462054); (R-MMU-1592389); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10506205;36240716;36288343;3641189", "class_list": "", "function": "PRSS2 overexpression relates to poor prognosis and promotes proliferation, migration and invasion in gastric cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.22;3.4.24.34;3.4.22.27;1.1.1.42;4.1.2.13;3.4.21.4;3.4.21.-;3.2.1.17;1.16.3.1;3.4.23.5;3.4.21.39;3.4.21.59;3.3.2.6;3.4.11.4;3.4.21.34;3.4.21.20;3.4.24.17;3.1.3.48;3.4.24.-;3.4.24.35;3.5.4.5;3.4.24.23;3.4.21.37;1.8.3.2;3.6.1.6;3.4.21.1;2.3.2.5;5.4.2.2;3.2.1.14;3.4.24.7;3.5.1.3;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0007584 response to nutrient;GO:0035094 response to nicotine;GO:0031000 response to caffeine;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P07146-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35441-1", "uniprot_id": "TSP1_MOUSE", "mass": 129647.0, "length": 1170, "protein_name": "Thrombospondin-1", "gene_name": "Thbs1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Thbs1; Tsp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Thrombospondin-1; Glycoprotein G", "protein_names_refseq": "", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); prostate cancer (Disease Ontology:DOID:10283); primary open angle glaucoma (Disease Ontology:DOID:1070); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); Sjogren's syndrome (Disease Ontology:DOID:12894); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-MMU-114608); (R-MMU-186797); (R-MMU-216083); (R-MMU-5173214)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;1371115;1774063;18156939;19656770;20571061;20610415;22682248;23591719;23757408;2398070;25835637;27742621;29042481;32679764;34887587;37507081;37828378;39627609;8654563", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (By similarity). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis (By similarity). Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis (By similarity). Ligand for receptor CD47 (By similarity). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (PubMed:20610415). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (PubMed:29042481). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (PubMed:23591719). Negatively modulates wound healing, acting via CD47 (PubMed:18156939). Ligand for receptor CD36 (By similarity). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (PubMed:25835637). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 (By similarity). Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner (PubMed:29042481). Ligand for immunoglobulin-like cell surface receptor SIRPA (By similarity). Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (By similarity). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (PubMed:23757408). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (PubMed:22682248). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (PubMed:29042481, PubMed:32679764)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 4, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 13, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0032693 negative regulation of interleukin-10 production;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P35441-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47750-1", "uniprot_id": "TSHR_MOUSE", "mass": 86583.0, "length": 764, "protein_name": "Thyrotropin receptor", "gene_name": "Tshr", "organism": "Mouse", "refseq_name": "thyrotropin receptor isoform 1 precursor", "refseq_ac": "NP_035778", "gene_names_uniprotkb": "Tshr", "gene_names_refseq": "Tshr; hypothroid; hyt; pet", "protein_names_uniprotkb": "Thyrotropin receptor; TSH-R; Thyroid-stimulating hormone receptor", "protein_names_refseq": "TSH-R; thyrotropin receptor isoform 1 precursor; thyrotropin receptor", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); cardiomyopathy (Disease Ontology:DOID:0050700); congenital nongoitrous hypothyroidism 1 (Disease Ontology:DOID:0070126); nonautoimmune hyperthyroidism (Disease Ontology:DOID:0081101); familial gestational hyperthyroidism (Disease Ontology:DOID:0081102); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Graves' disease (Disease Ontology:DOID:12361); hyperthyroidism (Disease Ontology:DOID:7998); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:22095); (R-MMU-375281); (R-MMU-418555)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12432094;21750661;8170469", "class_list": "", "function": "Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (PubMed:12432094). Additionally, plays a central role in controlling thyroid cell metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q562E4;Q9D697", "ec_number_list": "", "go_molecular_function": "GO:0004996 thyroid-stimulating hormone receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0044877 protein-containing complex binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008344 adult locomotory behavior;GO:0040012 regulation of locomotion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50586-1", "uniprot_id": "TUB_MOUSE", "mass": 55362.0, "length": 505, "protein_name": "Tubby protein", "gene_name": "Tub", "organism": "Mouse", "refseq_name": "tubby protein", "refseq_ac": "NP_068685", "gene_names_uniprotkb": "Tub; Rd5", "gene_names_refseq": "Tub; rd5", "protein_names_uniprotkb": "Tubby protein", "protein_names_refseq": "retinal degeneration 5; tubby bipartite transcription factor; tubby candidate; tubby protein", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22141)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10591637;11375483;19695251;19837063;21750661;33213002;36104704;8606774;8612280", "class_list": "", "function": "Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity)., [UniProtKB, PubMed, PubMed]; Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia. Publication Status: Online-Only, [RefSeq, PubMed]; TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0044877 protein-containing complex binding;GO:0120160 intraciliary transport particle A binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0050766 positive regulation of phagocytosis;GO:0007605 sensory perception of sound;GO:0006910 phagocytosis, recognition", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02844-1", "uniprot_id": "TRYB1_MOUSE", "mass": 30337.0, "length": 273, "protein_name": "Tryptase", "gene_name": "Tpsab1", "organism": "Mouse", "refseq_name": "tryptase precursor", "refseq_ac": "NP_112464", "gene_names_uniprotkb": "Tpsab1; Mcpt7", "gene_names_refseq": "MMCP-7; Mcp-7; Mcp7; Mcpt7; Tpsab1", "protein_names_uniprotkb": "Tryptase; 3.4.21.59; Mast cell protease 7; Tryptase alpha/beta-1; mMCP-7", "protein_names_refseq": "mast cell protease 7; mast cell-restricted serine protease 7; tryptase precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503895)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1454796;18668540;21750661;31013764;37828378;8576265", "class_list": "", "function": "Because mMCP-6 and mMCP-7 can compensate for each other in this mouse disease model, the elimination of both tryptases is necessary to reveal the prominent roles of these serine proteases in joint inflammation and destruction., [RefSeq, PubMed]; Data indicate that the direct degradation of the integrin subunits by rmMCP-7 is sufficient to initiate angiogenesis. The results demonstrate, for the first time, that mMCP-7 acts in angiogenesis through integrin degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0042629 mast cell granule;GO:1905368 peptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0030195 negative regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R207-1", "uniprot_id": "NBN_MOUSE", "mass": 83795.0, "length": 751, "protein_name": "Nibrin", "gene_name": "Nbn", "organism": "Mouse", "refseq_name": "nibrin", "refseq_ac": "NP_038780", "gene_names_uniprotkb": "Nbn; Nbs1", "gene_names_refseq": "Nbn; Nbs1", "protein_names_uniprotkb": "Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1 homolog", "protein_names_refseq": "cell cycle regulatory protein p95; nibrin; nijmegen breakage syndrome protein 1 homolog", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); aplastic anemia (Disease Ontology:DOID:12449); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); ovarian cancer (Disease Ontology:DOID:2394); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); Nijmegen breakage syndrome (Disease Ontology:DOID:7400); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:27354); (R-MMU-2559586); (R-MMU-5685938); (R-MMU-5685939); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693548); (R-MMU-5693565); (R-MMU-5693568); (R-MMU-5693571); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 15, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10640816;10915761;11231126;12470659;17291760;17376776;17525332;21183079;21664921;21750661;22464731;28216226;29285240;30017584;30084848;30779550;34428180;35839783;37296499;37466852;38961290", "class_list": "", "function": "A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma., [RefSeq, PubMed]; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:17291760, PubMed:22464731, PubMed:28216226). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (By similarity). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (By similarity). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:22464731). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (By similarity). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (By similarity). The MRN complex is also required for the processing of R-loops (By similarity). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance., [RefSeq, PubMed]; Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers high-grade gliomas., [RefSeq, PubMed]; The Effect of Inactivating Heterozygous Mutation in NBS1 Gene on DNA Damage and Repair Markers and Apoptosis Markers in Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88981;Q3UY57;Q811I6;Q8CCY0;Q9R1X1", "ec_number_list": "", "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0042393 histone binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140031 phosphorylation-dependent protein binding;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0016605 PML body", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0043247 telomere maintenance in response to DNA damage;GO:0001701 in utero embryonic development;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9R207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BIM8-1", "uniprot_id": "MUP18_MOUSE", "mass": 20763.0, "length": 181, "protein_name": "Major urinary protein 18", "gene_name": "Mup11; Mup18; Mup9", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mup11; Mup18; Mup9; Mup16; Mup9", "gene_names_refseq": "", "protein_names_uniprotkb": "Major urinary protein 18", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039028); (mmu:100048884)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18815613;21750661", "class_list": "", "function": "Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BIM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4Q0-1", "uniprot_id": "RPTOR_MOUSE", "mass": 149471.0, "length": 1335, "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "Rptor", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rptor; Raptor", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulatory-associated protein of mTOR; Raptor; p150 target of rapamycin (TOR)-scaffold protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742)", "pathway": " (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-3371571); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;12150926;15345747;17141160;18439900;19144319;19346248;20801936;21183079;21750661;26588989;27879318;30197302;30984011;31112131;31219806;32912901;33300544;33495318;34428180;35820727;39388284;40885482", "class_list": "", "function": "Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:27879318, PubMed:32912901). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:27879318). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (By similarity). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (By similarity). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (By similarity). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (PubMed:27879318, PubMed:30984011, PubMed:33495318). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (PubMed:33495318)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9W9;Q8CBY4;Q8CDY8;Q9D4H3", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0030295 protein kinase activator activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1901331 positive regulation of odontoblast differentiation;GO:0000045 autophagosome assembly;GO:0010506 regulation of autophagy;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q8K4Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70583-1", "uniprot_id": "TRI18_MOUSE", "mass": 76136.0, "length": 680, "protein_name": "E3 ubiquitin-protein ligase Midline-1", "gene_name": "Mid1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Midline-1 isoform 2", "refseq_ac": "NP_001277433", "gene_names_uniprotkb": "Mid1; Fxy; Trim18", "gene_names_refseq": "61B3-R; DXHXS1141; Fxy; Mid1; Trim18", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Midline-1; 2.3.2.27; Midin; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18", "protein_names_refseq": "E3 ubiquitin-protein ligase Midline-1 isoform 2; E3 ubiquitin-protein ligase Midline-1; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; midin; tripartite motif-containing protein 18", "tax_id": 10090, "disease": "Opitz GBBB syndrome (Disease Ontology:DOID:0080697); microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (mmu:17318)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11371618;21750661;24788674;25428506;31599954;35820727;38323310;38777113;9342357;9467009;9722948", "class_list": "", "function": "Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification., [RefSeq, PubMed]; Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AV00;O35418;Q7TPT6", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007026 negative regulation of microtubule depolymerization;GO:0070507 regulation of microtubule cytoskeleton organization;GO:0032874 positive regulation of stress-activated MAPK cascade;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O70583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T11-1", "uniprot_id": "USH1G_MOUSE", "mass": 51490.0, "length": 461, "protein_name": "pre-mRNA splicing regulator USH1G", "gene_name": "Ush1g", "organism": "Mouse", "refseq_name": "pre-mRNA splicing regulator USH1G", "refseq_ac": "NP_789817", "gene_names_uniprotkb": "Ush1g; Sans", "gene_names_refseq": "Sans; Ush1g; js", "protein_names_uniprotkb": "pre-mRNA splicing regulator USH1G; Jackson shaker protein; Scaffold protein containing ankyrin repeats and SAM domain; Usher syndrome type-1G protein homolog", "protein_names_refseq": "Usher syndrome 1G homolog; jackson shaker protein; pre-mRNA splicing regulator USH1G; scaffold protein containing ankyrin repeats and SAM domain; scaffold protein, amkyrin repeats and SAM domain containing; scaffold protein, ankyrin repeats and SAM domain containing; usher syndrome type-1G protein homolog", "tax_id": 10090, "disease": "Usher syndrome type 1G (Disease Ontology:DOID:0110834)", "pathway": " (mmu:16470)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12588793;12588794;21436032;21709241;24608321;28966015;29386551;31637240", "class_list": "", "function": "C-terminal hairpin extensions of the whirlin PDZ domains mediate the transient supramodular assembly, which improves the binding capacity of the first domain towards its partners, such as Sans., [RefSeq, PubMed]; Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs (By similarity). May also participate in recycling of snRNPs back to Cajal bodies during splicing (By similarity). Plays a role in regulating MAGI2-mediated endocytosis (By similarity). Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing., [UniProtKB, PubMed, PubMed, UniProtKB]; Sans may have an important role in development of the stereocilia bundles, [RefSeq, PubMed]; This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with combined auditory and vision loss. [provided by RefSeq, Sep 2015]., [RefSeq]; Under normal housing conditions, Ush1g(-/-) and Ush1c(-/-) albino mice have dysfunctional cone photoreceptors whereas pigmented knockout animals have normal photoreceptors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UG0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0045494 photoreceptor cell maintenance;GO:2000369 regulation of clathrin-dependent endocytosis;GO:0007605 sensory perception of sound;GO:0060113 inner ear receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80T11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZQ5-1", "uniprot_id": "RPE65_MOUSE", "mass": 61085.0, "length": 533, "protein_name": "Retinoid isomerohydrolase", "gene_name": "Rpe65", "organism": "Mouse", "refseq_name": "retinoid isomerohydrolase", "refseq_ac": "NP_084263", "gene_names_uniprotkb": "Rpe65", "gene_names_refseq": "65kDa; A930029L06Rik; LCA2; Mord1; RP20; Rpe65; rd12", "protein_names_uniprotkb": "Retinoid isomerohydrolase; 3.1.1.64; 5.3.3.22; All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; Retinal pigment epithelium-specific 65 kDa protein; Retinol isomerase", "protein_names_refseq": "all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; modifier of retinal degeneration 1; retinal pigment epithelium, 65 kDa; retinal pigment epithelium-specific 65 kDa protein; retinoid isomerohydrolase; retinol isomerase", "tax_id": 10090, "disease": "Leber congenital amaurosis 2 (Disease Ontology:DOID:0110016); retinitis pigmentosa 20 (Disease Ontology:DOID:0110353); retinitis pigmentosa 87 (Disease Ontology:DOID:0112144); retinitis pigmentosa (Disease Ontology:DOID:10584); squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (mmu:19892); (R-MMU-2453902)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11150319;11740468;15765048;17251447;18474598;21750661;23407971;28500718;29659842;30628748;9843205", "class_list": "", "function": "Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:15765048, PubMed:23407971, PubMed:28500718, PubMed:9843205). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17251447). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Knockout of the Rpe65 gene gave severely night-blind animals with lack of 11-cis retinoids in retina and excess of all-trans retinyl esters in the retinal pigment epithelium,consistent with blockade of the all-trans to 11-cis isomerization of retinoids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3D1;E9QNS6;H9KUX9;Q8VHP2", "ec_number_list": "3.1.1.64;5.3.3.22", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031210 phosphatidylcholine binding;GO:0001786 phosphatidylserine binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0001523 retinoid metabolic process;GO:0003407 neural retina development;GO:0042572 retinol metabolic process;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91ZQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99K90-1", "uniprot_id": "TAB2_MOUSE", "mass": 76442.0, "length": 693, "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "Tab2", "organism": "Mouse", "refseq_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "refseq_ac": "NP_619608", "gene_names_uniprotkb": "Tab2; Kiaa0733; Map3k7ip2", "gene_names_refseq": "1110030N06Rik; A530078N03Rik; Map3k7ip2; Tab2; mKIAA0733", "protein_names_uniprotkb": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAK1-binding protein 2; TGF-beta-activated kinase 1-binding protein 2", "protein_names_refseq": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2; Tak1 binding protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:68652); (R-MMU-168638); (R-MMU-202424); (R-MMU-2871837); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-5357956); (R-MMU-5607764); (R-MMU-9020702); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-975163)", "pathway_count": 14, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;12150997;12433684;12556483;17242355;19144319;19224205;19927120;20173027;20484733;21183079;21750661;22872234;23443134;24129315;25428506;30016717;30059200;30084848;30779550;31219806;32152506;32782141;32848054;34203471;34428180;35820727;35822049;36852467;37116711;39358475;40021952;40885482", "class_list": "", "function": "Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (By similarity). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (By similarity). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:19927120). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (PubMed:12150997). Involved in heart development (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; TAB2 is essential for embryonic development through prevention of liver apoptosis but not for the IL-1 receptor-mediated signaling pathway., [RefSeq, PubMed]; The antisense lncRNA of TAB2 that prevents oxidative stress to enhance the follicular growth in mammals. Publication Status: Online-Only, [RefSeq, PubMed]; The expression of mouse TAB2 in the E11 dorsal aorta endothelium suggests a role for mTAB2 in hematopoietic stem cell emergence and/or regulation, [RefSeq, PubMed]; Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGP1;Q8BTP4;Q8CHD3;Q99KP4", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007507 heart development;GO:0032496 response to lipopolysaccharide;GO:0045860 positive regulation of protein kinase activity;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q99K90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVS7-1", "uniprot_id": "MP2K5_MOUSE", "mass": 50105.0, "length": 448, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 5", "gene_name": "Map2k5", "organism": "Mouse", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 5 isoform 1", "refseq_ac": "NP_035970", "gene_names_uniprotkb": "Map2k5; Mek5; Mkk5; Prkmk5", "gene_names_refseq": "MEK5; Map2k5; Mapkk5; Prkmk5", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 5; 2.7.12.2; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5", "protein_names_refseq": "MAP kinase kinase 5; MAPK/ERK kinase 5; dual specificity mitogen-activated protein kinase kinase 5 isoform 1; dual specificity mitogen-activated protein kinase kinase 5", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:23938)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10473620;12813044;12912994;16507987;30442718;32745297", "class_list": "", "function": "Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; MEK5 promotes lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression., [RefSeq, PubMed]; PB1 domain mediates the association of MEKK2 and MEKK3 with MEK5 and that the respective PB1 domains of these kinases are critical for regulation of the ERK5 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9652, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFM3;Q8K360;Q9D222", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.10.1;2.7.12.1;2.7.11.22;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0070375 ERK5 cascade;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WVS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48432-1", "uniprot_id": "SOX2_MOUSE", "mass": 34454.0, "length": 319, "protein_name": "Transcription factor SOX-2", "gene_name": "Sox2", "organism": "Mouse", "refseq_name": "transcription factor SOX-2", "refseq_ac": "NP_035573", "gene_names_uniprotkb": "Sox2; Sox-2", "gene_names_refseq": "Sox-2; Sox2; lcc; ysb", "protein_names_uniprotkb": "Transcription factor SOX-2", "protein_names_refseq": "SRY-box containing gene 2; transcription factor SOX-2", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); traumatic brain injury (Disease Ontology:DOID:0081292); syndromic microphthalmia 3 (Disease Ontology:DOID:0111801); nasal cavity cancer (Disease Ontology:DOID:10811); lesion of sciatic nerve (Disease Ontology:DOID:12528); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); cholangiocarcinoma (Disease Ontology:DOID:4947); congestive heart failure (Disease Ontology:DOID:6000); retinal degeneration (Disease Ontology:DOID:8466); oral cavity cancer (Disease Ontology:DOID:8618)", "pathway": " (mmu:20674); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "15863505;16904174;17097055;17728342;19349578;19740739;20945330;21606357;22198669;22608532;22645316;24116102;25042802;26949256;27311888;28607354;29358331;30442713;32127020;32703285;32758484;32782141;32848054;34678516;34819616;35604954;36852467;40021952;40128797;40885482;7590241;8625802", "class_list": "", "function": "This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015]., [RefSeq]; Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0050998 nitric-oxide synthase binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0021879 forebrain neuron differentiation;GO:0048852 diencephalon morphogenesis;GO:0001708 cell fate specification;GO:0021984 adenohypophysis development", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P48432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LI5-1", "uniprot_id": "ZN281_MOUSE", "mass": 96685.0, "length": 893, "protein_name": "Zinc finger protein 281", "gene_name": "Znf281", "organism": "Mouse", "refseq_name": "zinc finger protein 281", "refseq_ac": "NP_001153723", "gene_names_uniprotkb": "Znf281; Zfp281", "gene_names_refseq": "Zfp281; Znf281", "protein_names_uniprotkb": "Zinc finger protein 281", "protein_names_refseq": "zinc finger protein 281", "tax_id": 10090, "disease": "", "pathway": " (mmu:226442)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;18757296;19144319;21606357;21915945;22988117;25428506;25605945;28528544;29237092;32782141;33049031;34428180;34678516;36852467;37948511;38237590;40128797;40885482;40997131", "class_list": "", "function": "LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency., [RefSeq, PubMed]; Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes., [UniProtKB, PubMed, PubMed, PubMed]; ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1., [RefSeq, PubMed]; Zfp281 and Zfp148 control CD4[+] T cell thymic development and TH2 functions., [RefSeq, PubMed]; Zfp281 plays bifunctional roles in regulating gene expression within the network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3U063;Q4FK52", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q99LI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60945-1", "uniprot_id": "MTCP1_MOUSE", "mass": 12645.0, "length": 107, "protein_name": "Protein p13 MTCP-1", "gene_name": "Mtcp1", "organism": "Mouse", "refseq_name": "protein p13 MTCP-1", "refseq_ac": "NP_001034462", "gene_names_uniprotkb": "Mtcp1; C6.1b", "gene_names_refseq": "Mtcp1; P13MTCP1", "protein_names_uniprotkb": "Protein p13 MTCP-1; MTCP-1 type B1; Mature T-cell proliferation-1 type B1; p13MTCP1", "protein_names_refseq": "MTCP-1 type B1; mature T-cell proliferation-1 type B1; protein p13 MTCP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17763)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34732719;8634440", "class_list": "", "function": "Enhances the phosphorylation and activation of AKT1 and AKT2., [UniProtKB]; Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGA7", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60945-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXD6-1", "uniprot_id": "MCUR1_MOUSE", "mass": 37849.0, "length": 340, "protein_name": "Mitochondrial calcium uniporter regulator 1", "gene_name": "Mcur1", "organism": "Mouse", "refseq_name": "mitochondrial calcium uniporter regulator 1", "refseq_ac": "NP_001074528", "gene_names_uniprotkb": "Mcur1; Ccdc90a", "gene_names_refseq": "6230416A05Rik; Ccdc90a; Mcur1", "protein_names_uniprotkb": "Mitochondrial calcium uniporter regulator 1; Coiled-coil domain-containing protein 90A, mitochondrial; MCU regulator 1", "protein_names_refseq": "MCU regulator 1; coiled-coil domain containing 90A; coiled-coil domain-containing protein 90A, mitochondrial; mitochondrial calcium uniporter regulator 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76137)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23576753;27184846;31219806", "class_list": "", "function": "Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex)., [UniProtKB, UniProtKB]; MCUR1 binds to MCU and EMRE and function as a scaffold factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14DH8;Q3V3D3", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0051291 protein heterooligomerization;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CXD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J59-1", "uniprot_id": "TSN1_MOUSE", "mass": 26356.0, "length": 240, "protein_name": "Tetraspanin-1", "gene_name": "Tspan1", "organism": "Mouse", "refseq_name": "tetraspanin-1", "refseq_ac": "NP_598442", "gene_names_uniprotkb": "Tspan1", "gene_names_refseq": "9030418M05Rik; Tspan1", "protein_names_uniprotkb": "Tetraspanin-1; Tspan-1", "protein_names_refseq": "tetraspan 1; tetraspanin-1; tspan-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66805)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (By similarity). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (By similarity). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6PW93", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99J59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVF8-1", "uniprot_id": "TUSC2_MOUSE", "mass": 12136.0, "length": 110, "protein_name": "Tumor suppressor candidate 2", "gene_name": "Tusc2", "organism": "Mouse", "refseq_name": "tumor suppressor candidate 2", "refseq_ac": "NP_062716", "gene_names_uniprotkb": "Tusc2; Fus1; Lgcc; Pdap2", "gene_names_refseq": "1190001E22Rik; Fus1; Lgcc; PAP; Pdap2; Tusc2", "protein_names_uniprotkb": "Tumor suppressor candidate 2; Fus-1 protein; Fusion 1 protein; PDGFA-associated protein 2", "protein_names_refseq": "PDGFA associated protein 2; fus-1 protein; fusion 1 protein; lung cancer candidiate, FUS; tumor suppressor candidate 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80385)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;24328503;28391779;39000512", "class_list": "", "function": "Fus1 achieves its protective role in inflammation, autoimmunity, and cancer via the regulation of mitochondrial calcium and calcium-coupled parameters., [RefSeq, PubMed]; Loss of Mitochondrial Tusc2/Fus1 Triggers a Brain Pro-Inflammatory Microenvironment and Early Spatial Memory Impairment. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that Tusc2 acts as a positive regulator of RANKL-mediated osteoclast differentiation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0032700 negative regulation of interleukin-17 production;GO:0006954 inflammatory response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922J6-1", "uniprot_id": "TSN2_MOUSE", "mass": 24181.0, "length": 221, "protein_name": "Tetraspanin-2", "gene_name": "Tspan2", "organism": "Mouse", "refseq_name": "tetraspanin-2 isoform 1", "refseq_ac": "NP_081809", "gene_names_uniprotkb": "Tspan2", "gene_names_refseq": "6330415F13Rik; B230119D02Rik; Tspan2; tspan-2", "protein_names_uniprotkb": "Tetraspanin-2; Tspan-2", "protein_names_refseq": "tetraspan 2; tetraspanin-2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70747)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24038504;30084848;30779550;30899004;33300544;34428180", "class_list": "", "function": "May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The activation of astrocytes and microglia was strongly enhanced in Tspan2(null) *Plp1(null) double-mutants compared with either single-mutant, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q543K4;Q9D397", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0014005 microglia development;GO:0042552 myelination;GO:0014002 astrocyte development;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q922J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921J4-1", "uniprot_id": "UBE2S_MOUSE", "mass": 24183.0, "length": 223, "protein_name": "Ubiquitin-conjugating enzyme E2 S", "gene_name": "Ube2s", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 S", "refseq_ac": "NP_598538", "gene_names_uniprotkb": "Ube2s; E2epf", "gene_names_refseq": "0910001J09Rik; 6720465F12Rik; E2-EPF; Ube2s", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 S; 2.3.2.23; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-protein ligase S", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme S; E2-EPF5; ubiquitin carrier protein S; ubiquitin-conjugating enzyme E2 S; ubiquitin-conjugating enzyme E2-24 kDa; ubiquitin-conjugating enzyme E2-EPF5; ubiquitin-protein ligase S", "tax_id": 10090, "disease": "", "pathway": " (mmu:77891); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 18, "publication_count": 6, "publication_id_list": "21750661;26207029;26292759;32250966;32814047;38546043", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Alongside their canonical function in protein degradation, Ube2C and -S also control the extrusion of the first polar body., [RefSeq, PubMed]; Besides its role in fine-tuning the precise level of Sox2, Ube2s reinforces the self-renewing and pluripotent state of embryonic stem cells., [RefSeq, PubMed]; Loss of UBE2S causes meiosis I arrest with normal spindle assembly checkpoint dynamics in mouse oocytes., [RefSeq, PubMed]; Ube2s-stabilized beta-catenin protects against myocardial ischemia/reperfusion injury by activating HIF-1alpha signaling., [RefSeq, PubMed]; Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4V7;Q8CF67", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;3.4.19.12;2.7.11.1;3.4.25.1;2.7.11.22;2.7.11.23;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;6.2.1.45;2.7.11.21;2.1.1.-;2.1.1.367;6.2.1.64;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0010997 anaphase-promoting complex binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q921J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0Q3-1", "uniprot_id": "TTC34_MOUSE", "mass": 60220.0, "length": 554, "protein_name": "Tetratricopeptide repeat protein 34", "gene_name": "Ttc34", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 34", "refseq_ac": "NP_766466", "gene_names_uniprotkb": "Ttc34", "gene_names_refseq": "4932418L02; B230396O12Rik; Ttc34", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 34; TPR repeat protein 34", "protein_names_refseq": "TPR repeat protein 34; tetratricopeptide repeat protein 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:242800)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;34887587", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AS13;Q6NV67", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C0Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY33-1", "uniprot_id": "TSN3_MOUSE", "mass": 28049.0, "length": 253, "protein_name": "Tetraspanin-3", "gene_name": "Tspan3", "organism": "Mouse", "refseq_name": "tetraspanin-3", "refseq_ac": "NP_062767", "gene_names_uniprotkb": "Tspan3; Tm4sf8", "gene_names_refseq": "1700055K04Rik; TM4-A; Tm4sf8; Tspan3", "protein_names_uniprotkb": "Tetraspanin-3; OAP-1; OSP-associated protein 1; Tetraspanin TM4-A; Transmembrane 4 superfamily member 8; Tspan-3", "protein_names_refseq": "H41D4 protein; OAP-1; OSP-associated protein 1; tetraspanin TM4-A homolog; tetraspanin-3; transmembrane 4 superfamily member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:56434)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11092739;11309411;21750661;26212080;26495903;27818272;30899004;34428180;35326428", "class_list": "", "function": "Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced Trabecular Bone Mass Caused by Decreased Osteoblast Functions. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair., [UniProtKB, UniProtKB, UniProtKB]; Tspan3 is a central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein., [RefSeq, PubMed]; Tspan3 is an important regulator of aggressive leukemias., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 8818, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQG4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9QY33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3G9-1", "uniprot_id": "TSN8_MOUSE", "mass": 25582.0, "length": 235, "protein_name": "Tetraspanin-8", "gene_name": "Tspan8", "organism": "Mouse", "refseq_name": "tetraspanin-8", "refseq_ac": "NP_001162150", "gene_names_uniprotkb": "Tspan8", "gene_names_refseq": "E330007O21Rik; Tm4sf3; Tspan8", "protein_names_uniprotkb": "Tetraspanin-8; Tspan-8", "protein_names_refseq": "tetraspanin-8; transmembrane 4 superfamily member 3; tspan-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:216350)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;20733586;21750661;32195353;37204469;39927985", "class_list": "", "function": "Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR. Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration. Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin., [UniProtKB, UniProtKB]; Tetraspanin Tspan8 restrains interferon signaling to stabilize intestinal epithelium by directing endocytosis of interferon receptor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030195 negative regulation of blood coagulation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R3G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAC7-1", "uniprot_id": "TTC32_MOUSE", "mass": 16796.0, "length": 148, "protein_name": "Tetratricopeptide repeat protein 32", "gene_name": "Ttc32", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 32", "refseq_ac": "NP_083597", "gene_names_uniprotkb": "Ttc32", "gene_names_refseq": "1700013G20Rik; Ttc32", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 32; TPR repeat protein 32", "protein_names_refseq": "TPR repeat protein 32; tetratricopeptide repeat protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:75516)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFI2-1", "uniprot_id": "UB2R1_MOUSE", "mass": 26622.0, "length": 235, "protein_name": "Ubiquitin-conjugating enzyme E2 R1", "gene_name": "Cdc34", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 R1 isoform 1", "refseq_ac": "NP_808281", "gene_names_uniprotkb": "Cdc34; Ubch3; Ube2r1", "gene_names_refseq": "Cdc34; E2-CDC34; UBE2R1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 R1; (E3-independent) E2 ubiquitin-conjugating enzyme R1; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme R1; E2 ubiquitin-conjugating enzyme R1; cell division cycle 34 homolog; ubiquitin-conjugating enzyme Cdc34; ubiquitin-conjugating enzyme E2 R1 isoform 1; ubiquitin-conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; ubiquitin-protein ligase R1", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:216150); (R-MMU-202424); (R-MMU-2871837); (R-MMU-5607764); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10230406;21750661;32640224;32782141", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (By similarity). In vitro catalyzes 'Lys-48'-linked polyubiquitination (By similarity). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation (PubMed:10230406). Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1 (By similarity). Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation (By similarity). Also involved in the degradation of beta-catenin (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q505K8", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;6.2.1.45;2.7.11.1;6.2.1.64;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0043525 positive regulation of neuron apoptotic process;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CFI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TLI0-1", "uniprot_id": "TPC10_MOUSE", "mass": 141493.0, "length": 1258, "protein_name": "Trafficking protein particle complex subunit 10", "gene_name": "Trappc10", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 10", "refseq_ac": "NP_001074524", "gene_names_uniprotkb": "Trappc10; Tmem1", "gene_names_refseq": "B230307C21Rik; Gm870; Tmem1; Trappc10; b2b2416Clo; b2b2613Clo", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 10; TRAPP subunit TMEM1; Trafficking protein particle complex subunit TMEM1; Transport protein particle subunit TMEM1", "protein_names_refseq": "TRAPP subunit TMEM1; trafficking protein particle complex subunit 10; trafficking protein particle complex subunit TMEM1; transmembrane protein 1", "tax_id": 10090, "disease": "agnathia-otocephaly complex (Disease Ontology:DOID:0060341); velocardiofacial syndrome (Disease Ontology:DOID:12583)", "pathway": " (mmu:216131); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;19656848;21750661;25428506;29187734;30084848;30779550;31219806;34428180;35298461", "class_list": "", "function": "Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8VQF9;Q811H4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030008 TRAPP complex;GO:1990071 TRAPPII protein complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0034498 early endosome to Golgi transport;GO:0006901 vesicle coating;GO:0099022 vesicle tethering", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3TLI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4K3-1", "uniprot_id": "TRIB2_MOUSE", "mass": 38773.0, "length": 343, "protein_name": "Tribbles homolog 2", "gene_name": "Trib2", "organism": "Mouse", "refseq_name": "tribbles homolog 2", "refseq_ac": "NP_653134", "gene_names_uniprotkb": "Trib2", "gene_names_refseq": "TRB-2; TRB2; Trib2", "protein_names_uniprotkb": "Tribbles homolog 2; TRB-2", "protein_names_refseq": "tribbles homolog 2", "tax_id": 10090, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:217410)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17097562;17576771;17988908;21750661;30084848;34428180;36884349;38394623", "class_list": "", "function": "Data identify Tribbles homolog 2 as an oncogene that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha., [RefSeq, PubMed]; Describe suppression of adipocyte differentiation by TRBs Trib1, Trib2, Trib3, [RefSeq, PubMed]; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mice reconstituted with HSC cotransduced with HoxA9 and Trib2 had accelerated onset of AML compared to either gene alone, [RefSeq, PubMed]; TRIB2 safeguards naive T cell homeostasis during aging., [RefSeq, PubMed]; TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K017;Q8R2V8", "ec_number_list": "", "go_molecular_function": "GO:0055106 ubiquitin-protein transferase regulator activity;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0004860 protein kinase inhibitor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045599 negative regulation of fat cell differentiation;GO:0043405 regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K4K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXE5-1", "uniprot_id": "TSSP_MOUSE", "mass": 54523.0, "length": 509, "protein_name": "Thymus-specific serine protease", "gene_name": "Prss16", "organism": "Mouse", "refseq_name": "thymus-specific serine protease precursor", "refseq_ac": "NP_062302", "gene_names_uniprotkb": "Prss16; Tssp", "gene_names_refseq": "Prss16; TSSP", "protein_names_uniprotkb": "Thymus-specific serine protease; 3.4.-.-; Serine protease 16", "protein_names_refseq": "protease, serine 16 (thymus); serine protease 16; thymus-specific serine protease precursor; thymus-specific serine protease", "tax_id": 10090, "disease": "", "pathway": " (mmu:54373)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10630289;12144812;15632078;21750661;25543139;26209627;29061767;35820727;36210013", "class_list": "", "function": "Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP)., [RefSeq, PubMed]; Data suggest that Prss16 is not required for quantitatively normal T-cell development., [RefSeq, PubMed]; Our data demonstrate that antitumoral immune surveillance requires thymic TSSP-driven production of CD4(+) T cells contributing to inflammatory balance., [RefSeq, PubMed]; Protease that may play a role in T-cell development., [UniProtKB]; Role of Prss16 in T-cell development and susceptibility to autoimmunity in the mouse, [RefSeq, PubMed]; These results show that TSSP increases experimental autoimmune encephalomyelitis severity by limiting central tolerance to myelin oligodendrocyte glycoprotein, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0070008 serine-type exopeptidase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QXE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPM3-1", "uniprot_id": "TRI17_MOUSE", "mass": 54863.0, "length": 477, "protein_name": "E3 ubiquitin-protein ligase TRIM17", "gene_name": "Trim17", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM17", "refseq_ac": "NP_112449", "gene_names_uniprotkb": "Trim17", "gene_names_refseq": "Rnf16; Trim17; terf", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM17; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM17; Tripartite motif-containing protein 17", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM17; RING-type E3 ubiquitin transferase TRIM17; ring finger protein 16; tripartite motif protein 17; tripartite motif protein TRIM17; tripartite motif-containing protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:56631)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11331580;19358823;20559321;21750661;22976837;25215946;30485814", "class_list": "", "function": "E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:20559321, PubMed:22976837, PubMed:25215946). Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death (PubMed:22976837). In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities (PubMed:25215946). Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (PubMed:30485814). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis, [RefSeq, PubMed]; Overexpression and silencing data indicate that Trim17 is necessary and sufficient for inducing the Bax-dependent intrinsic pathway of neuronal apoptosis and that its pro-apoptotic effect depends on its E3 activity., [RefSeq, PubMed]; Terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein., [RefSeq, PubMed]; Trim17 contributes to the ubiquitination and the proteasomal degradation of Mcl-1 in neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AB82;Q99PP8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0045087 innate immune response;GO:0032880 regulation of protein localization;GO:0006914 autophagy;GO:0010468 regulation of gene expression;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TPM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z38-1", "uniprot_id": "TTC1_MOUSE", "mass": 33263.0, "length": 292, "protein_name": "Tetratricopeptide repeat protein 1", "gene_name": "Ttc1", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 1", "refseq_ac": "NP_598556", "gene_names_uniprotkb": "Ttc1", "gene_names_refseq": "4833412C19Rik; TPR1; Ttc1", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 1; TPR repeat protein 1", "protein_names_refseq": "TPR repeat protein 1; tetratricopeptide repeat protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66827)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25153642;26495903;28135057;28528544;34428180", "class_list": "", "function": "Adapter protein that plays a role downstream of GNA15 to stimulate Ras activation and subsequent phosphorylation of ERK1/2 independently of phospholipase Cbeta signaling. Mechanistically, interacts with GNA15 and SOS2 to form a macromolecular signaling complex which has a high affinity for HRAS. Additionally, participates in signaling via other G-alpha proteins like GNA14, activating NF-kappa-B through Ras and ERK pathways. Beyond signaling, supports protein homeostasis by cooperating with HSP40 in the HSP70 chaperone cycle, promoting protein folding through the regulated dissociation of the HSP70 inhibitor HSPBP1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLM0", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0050729 positive regulation of inflammatory response;GO:0150078 positive regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91Z38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WG3-1", "uniprot_id": "TRUB2_MOUSE", "mass": 36807.0, "length": 331, "protein_name": "Pseudouridylate synthase TRUB2, mitochondrial", "gene_name": "Trub2", "organism": "Mouse", "refseq_name": "pseudouridylate synthase TRUB2, mitochondrial isoform c", "refseq_ac": "NP_001277425", "gene_names_uniprotkb": "Trub2", "gene_names_refseq": "G430055L02Rik; Trub2", "protein_names_uniprotkb": "Pseudouridylate synthase TRUB2, mitochondrial; 5.4.99.-; 5.4.99.25; Psi55 synthase TRUB2; TruB pseudouridine synthase homolog 2; tRNA pseudouridine 55 synthase TRUB2", "protein_names_refseq": "TruB pseudouridine (psi) synthase homolog 2; mitochondrial mRNA pseudouridine synthase Trub2; probable tRNA pseudouridine synthase 2; pseudouridylate synthase TRUB2, mitochondrial isoform c; pseudouridylate synthase TRUB2, mitochondrial; psi55 synthase TRUB2; tRNA pseudouridine 55 synthase TRUB2; truB pseudouridine synthase homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227682)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTK3", "ec_number_list": "5.4.99.-;5.4.99.42;5.4.99.28;5.4.99.25;5.4.99.12", "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0160148 tRNA pseudouridine(55) synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0006397 mRNA processing;GO:1990481 mRNA pseudouridine synthesis;GO:0070131 positive regulation of mitochondrial translation;GO:0070902 mitochondrial tRNA pseudouridine synthesis;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3H9-1", "uniprot_id": "CNS1_MOUSE", "mass": 44339.0, "length": 386, "protein_name": "Hsp70/Hsp90 co-chaperone CNS1 homolog", "gene_name": "Ttc4", "organism": "Mouse", "refseq_name": "hsp70/Hsp90 co-chaperone CNS1 homolog isoform 1", "refseq_ac": "NP_082485", "gene_names_uniprotkb": "Ttc4", "gene_names_refseq": "2810002P21Rik; L62; Ttc4", "protein_names_uniprotkb": "Hsp70/Hsp90 co-chaperone CNS1 homolog; TPR repeat protein 4; Tetratricopeptide repeat protein 4", "protein_names_refseq": "TPR repeat protein 4; hsp70/Hsp90 co-chaperone CNS1 homolog isoform 1; hsp70/Hsp90 co-chaperone CNS1 homolog; tetratricopeptide repeat protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72354)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17335777;19390865;21750661;24913909;31219806;34428180", "class_list": "", "function": "Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins (By similarity). Client proteins include eukaryotic elongation factor eEF2, a key player in cellular translation. Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Studies identi fi ed a novel signal of nuclear localization (NLS) in all MSL1 protein isoforms and found that the combination of both NLS allows for its intra-nuclear focal accumulation and nuclear transport of TTC4 while all MSL1 isoforms affect H4K16Ac., [RefSeq, PubMed]; The nuclear transport of TTC4 is apparently a complex process dependent on interactions with other proteins during the progression of the cell cycle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R3H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P073-1", "uniprot_id": "UB2J2_MOUSE", "mass": 28954.0, "length": 259, "protein_name": "Ubiquitin-conjugating enzyme E2 J2", "gene_name": "Ube2j2", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 J2 isoform a", "refseq_ac": "NP_001034246", "gene_names_uniprotkb": "Ube2j2; Ncube2", "gene_names_refseq": "1200007B18Rik; 2400008G19Rik; 5730472G04Rik; NCUBE-2; Ubc6p; Ubc6; Ube2j2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 J2; 2.3.2.23; NCUBE-2; Non-canonical ubiquitin-conjugating enzyme 2", "protein_names_refseq": "Ubc6p homolog; non-canonical ubiquitin-conjugating enzyme 2; ubiquitin conjugating enzyme 6; ubiquitin-conjugating enzyme E2 J2 isoform a; ubiquitin-conjugating enzyme E2, J2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:140499); (R-MMU-9609523); (R-MMU-983168)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11278356;12082160;19224205;19951915;20173027;21750661;25428506;34428180;35820727", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (PubMed:12082160). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells. The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage., [UniProtKB, PubMed, PubMed]; Ube2j2 is the primary cellular E2 recruited by the mK3 ligase, and this E2-E3 pair is capable of conjugating Ub on lysine or serine residues of substrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9884, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6A1;Q91Y64;Q9CWY5;Q9DC18;Q9QX58", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;1.14.14.18;1.2.1.3;1.2.1.94;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;6.2.1.45;2.7.11.1;6.2.1.64;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein;GO:0085020 protein K6-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6P073-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U269-1", "uniprot_id": "TSTD2_MOUSE", "mass": 55386.0, "length": 495, "protein_name": "Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2", "gene_name": "Tstd2", "organism": "Mouse", "refseq_name": "thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2", "refseq_ac": "NP_766621", "gene_names_uniprotkb": "Tstd2", "gene_names_refseq": "3010020C06; Tstd2", "protein_names_uniprotkb": "Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2", "protein_names_refseq": "likely ortholog of H. sapiens chromosome 9 open reading frame 97 (C9orf97); thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:272027)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AWH0;Q6PES9;Q8C1D7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3U269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRZ8-1", "uniprot_id": "TSPO2_MOUSE", "mass": 18286.0, "length": 162, "protein_name": "Translocator protein 2", "gene_name": "Tspo2", "organism": "Mouse", "refseq_name": "translocator protein 2", "refseq_ac": "NP_081568", "gene_names_uniprotkb": "Tspo2; Bzrpl1", "gene_names_refseq": "2510027D20Rik; Bzrpl1; Tspo2", "protein_names_uniprotkb": "Translocator protein 2; Peripheral-type benzodiazepine receptor-like protein 1", "protein_names_refseq": "benzodiazapine receptor, peripheral-like 1; peripheral-type benzodiazepine receptor-like protein 1; translocator protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70026)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19729679;21750661;32358067", "class_list": "", "function": "Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts., [RefSeq, PubMed]; Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679, PubMed:32358067). Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679, PubMed:32358067). May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Identify the TSPO2 family of proteins as mediators of cholesterol redistribution-dependent erythroblast maturation during mammalian erythropoiesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0140485 5-aminolevulinic acid transmembrane transporter activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0043353 enucleate erythrocyte differentiation;GO:0032367 intracellular cholesterol transport;GO:0034389 lipid droplet organization;GO:0098739 import across plasma membrane;GO:0140484 5-aminolevulinic acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CRZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1F5-1", "uniprot_id": "TTC16_MOUSE", "mass": 86945.0, "length": 767, "protein_name": "Tetratricopeptide repeat protein 16", "gene_name": "Ttc16", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 16 isoform c", "refseq_ac": "NP_001277493", "gene_names_uniprotkb": "Ttc16", "gene_names_refseq": "1200002K10Rik; Ttc16", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 16; TPR repeat protein 16", "protein_names_refseq": "TPR repeat protein 16; tetratricopeptide repeat protein 16 isoform c; tetratricopeptide repeat protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:338348)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C1F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JY4-1", "uniprot_id": "TRABD_MOUSE", "mass": 42189.0, "length": 376, "protein_name": "TraB domain-containing protein", "gene_name": "Trabd", "organism": "Mouse", "refseq_name": "traB domain-containing protein isoform 1", "refseq_ac": "NP_080761", "gene_names_uniprotkb": "Trabd", "gene_names_refseq": "5730502D15Rik; Trabd", "protein_names_uniprotkb": "TraB domain-containing protein", "protein_names_refseq": "traB domain-containing protein isoform 1; traB domain-containing protein", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:67976)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;37507081", "class_list": "", "function": "Along with MFN2, MIGA2 and PLD6 promotes mitochondrial clustering and fusion. May play a role in mitochondrial import of proteins, such as that of SLC25A19., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYF1", "ec_number_list": "", "go_molecular_function": "GO:0160204 mitochondrion-mitochondrion outer membrane tether activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0140596 TOM complex", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99JY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D658-1", "uniprot_id": "TP4A3_MOUSE", "mass": 19652.0, "length": 173, "protein_name": "Protein tyrosine phosphatase type IVA 3", "gene_name": "Ptp4a3", "organism": "Mouse", "refseq_name": "protein tyrosine phosphatase type IVA 3 isoform 1", "refseq_ac": "NP_001159860", "gene_names_uniprotkb": "Ptp4a3; Prl3", "gene_names_refseq": "Prl-3; Ptp4a3; pPtp4a3", "protein_names_uniprotkb": "Protein tyrosine phosphatase type IVA 3; 3.1.3.48; PRL-3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3", "protein_names_refseq": "protein tyrosine phosphatase type IVA 3 isoform 1; protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase of regenerating liver 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19245)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10747914;15161639;15673457;21750661;31219806;32918875;34129057;34428180;36210013;9514946", "class_list": "", "function": "PRL-3 was highly expressed in metastatic melanoma B16-BL6 cells but not in its lowly metastatic parental cell line, B16 cells, [RefSeq, PubMed]; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis., [RefSeq, PubMed]; The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70275;Q3T9Z5;Q9CTC8", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:1904951 positive regulation of establishment of protein localization;GO:0007219 Notch signaling pathway;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D658-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925I4-1", "uniprot_id": "TS1R2_MOUSE", "mass": 95736.0, "length": 843, "protein_name": "Taste receptor type 1 member 2", "gene_name": "Tas1r2", "organism": "Mouse", "refseq_name": "taste receptor type 1 member 2 precursor", "refseq_ac": "NP_114079", "gene_names_uniprotkb": "Tas1r2; Gpr71; T1r2; Tr2", "gene_names_refseq": "Gpr71; T1r2; TR2; Tas1r2", "protein_names_uniprotkb": "Taste receptor type 1 member 2; G protein-coupled receptor 71; Sweet taste receptor T1R2", "protein_names_refseq": "G-protein coupled receptor 71; candidate taste receptor T1R2; sweet taste receptor T1R2; taste receptor type 1 member 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:83770); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11319557;11509186;12892531;21750661;36210013;36484118;37938171;38851747", "class_list": "", "function": "Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners., [UniProtKB, UniProtKB, UniProtKB]; Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3., [RefSeq, PubMed]; Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4., [RefSeq, PubMed]; The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "B1AXX0;Q923J8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033041 sweet taste receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:1903767 sweet taste receptor complex;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0038037 G protein-coupled receptor dimeric complex", "go_biological_process": "GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste;GO:0032467 positive regulation of cytokinesis;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q925I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5C9-1", "uniprot_id": "TTMP_MOUSE", "mass": 24709.0, "length": 218, "protein_name": "TPA-induced transmembrane protein homolog", "gene_name": "BC016579", "organism": "Mouse", "refseq_name": "TPA-induced transmembrane protein homolog isoform 2", "refseq_ac": "NP_663364", "gene_names_uniprotkb": "BC016579", "gene_names_refseq": "BC016579", "protein_names_uniprotkb": "TPA-induced transmembrane protein homolog", "protein_names_refseq": "TPA-induced transmembrane protein homolog isoform 2; TPA-induced transmembrane protein homolog", "tax_id": 10090, "disease": "hypotrichosis 15 (Disease Ontology:DOID:0060968)", "pathway": " (mmu:212998)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YJ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C5C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UDE2-1", "uniprot_id": "TTL12_MOUSE", "mass": 74043.0, "length": 639, "protein_name": "Tubulin--tyrosine ligase-like protein 12", "gene_name": "Ttll12", "organism": "Mouse", "refseq_name": "tubulin--tyrosine ligase-like protein 12", "refseq_ac": "NP_898838", "gene_names_uniprotkb": "Ttll12", "gene_names_refseq": "D430005B17; Ttll12", "protein_names_uniprotkb": "Tubulin--tyrosine ligase-like protein 12; Inactive tubulin--tyrosine ligase-like protein 12", "protein_names_refseq": "TTL domain protein; inactive tubulin--tyrosine ligase-like protein 12; tubulin--tyrosine ligase-like protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:223723); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17499049;21750661", "class_list": "", "function": "Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPC3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016881 acid-amino acid ligase activity;GO:0140096 catalytic activity, acting on a protein;GO:0140005 histone H4K20me2 reader activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0007346 regulation of mitotic cell cycle;GO:0060339 negative regulation of type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UDE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NC05-1", "uniprot_id": "TTF2_MOUSE", "mass": 125530.0, "length": 1138, "protein_name": "Transcription termination factor 2", "gene_name": "Ttf2", "organism": "Mouse", "refseq_name": "transcription termination factor 2", "refseq_ac": "NP_001013044", "gene_names_uniprotkb": "Ttf2", "gene_names_refseq": "4632434F22Rik; 8030447N19; Ttf2", "protein_names_uniprotkb": "Transcription termination factor 2; 3.6.4.-; RNA polymerase II termination factor; Transcription release factor 2", "protein_names_refseq": "RNA polymerase II termination factor; transcription release factor 2; transcription termination factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74044)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9Y7;Q5M924", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006353 DNA-templated transcription termination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5NC05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDI7-1", "uniprot_id": "UBAC1_MOUSE", "mass": 45531.0, "length": 409, "protein_name": "Ubiquitin-associated domain-containing protein 1", "gene_name": "Ubac1", "organism": "Mouse", "refseq_name": "ubiquitin-associated domain-containing protein 1 isoform 1", "refseq_ac": "NP_598596", "gene_names_uniprotkb": "Ubac1; Kpc2; Ubadc1", "gene_names_refseq": "1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubac1; Ubadc1", "protein_names_uniprotkb": "Ubiquitin-associated domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Kip1 ubiquitination-promoting complex protein 2; UBA domain-containing protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase subunit KPC2; UBA domain-containing protein 1; kip1 ubiquitination-promoting complex protein 2; putative glialblastoma cell differentiation-related; ubiquitin-associated domain-containing protein 1 isoform 1; ubiquitin-associated domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:98766); (R-MMU-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26303204", "class_list": "", "function": "Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome., [UniProtKB, UniProtKB]; Our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZH3", "ec_number_list": "", "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VDI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W82-1", "uniprot_id": "UB2E2_MOUSE", "mass": 22241.0, "length": 201, "protein_name": "Ubiquitin-conjugating enzyme E2 E2", "gene_name": "Ube2e2", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 E2 isoform 1", "refseq_ac": "NP_659088", "gene_names_uniprotkb": "Ube2e2", "gene_names_refseq": "Ube2e2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 E2; 2.3.2.23; E2 ubiquitin-conjugating enzyme E2; Ubiquitin carrier protein E2; Ubiquitin-protein ligase E2", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme E2; TBC1 domain family, member 12; ubiquitin carrier protein E2; ubiquitin-conjugating enzyme E2 E2 isoform 1; ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast); ubiquitin-protein ligase E2", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:218793); (R-MMU-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;38064504", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein., [UniProtKB, UniProtKB]; Overexpression of UBE2E2 in Mouse Pancreatic beta-Cells Leads to Glucose Intolerance via Reduction of beta-Cell Mass., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;6.2.1.45;2.7.11.1;6.2.1.64;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0042296 ISG15 transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0006974 DNA damage response;GO:0070979 protein K11-linked ubiquitination;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91W82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922B6-1", "uniprot_id": "TRAF7_MOUSE", "mass": 66487.0, "length": 594, "protein_name": "E3 ubiquitin-protein ligase TRAF7", "gene_name": "Traf7", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Traf7", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRAF7; 2.3.2.-; 2.3.2.27; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "peritoneal mesothelioma (Disease Ontology:DOID:1788); hepatocellular carcinoma (Disease Ontology:DOID:684); adenomatoid tumor (Disease Ontology:DOID:746)", "pathway": " (mmu:224619); (R-MMU-983168); (R-MMU-9958825)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16162816;17242355;21183079;21750661;25428506;30084848;31219806;34428180;34953447", "class_list": "", "function": "E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:16162816, PubMed:34953447). Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators (By similarity). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (PubMed:16162816). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (By similarity). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JV3", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;3.6.5.2;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q922B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TW96-1", "uniprot_id": "UAP1L_MOUSE", "mass": 56614.0, "length": 507, "protein_name": "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1", "gene_name": "Uap1l1", "organism": "Mouse", "refseq_name": "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1", "refseq_ac": "NP_001028465", "gene_names_uniprotkb": "Uap1l1", "gene_names_refseq": "5730445F03Rik; Uap1l1", "protein_names_uniprotkb": "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; 2.7.7.-", "protein_names_refseq": "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acteylglucosamine pyrophosphorylase 1-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227620)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25153642;26740625;30097606;34428180", "class_list": "", "function": "Uap1l1 is upregulated in the liver of young MKO-hep mice without any macroscopically detectable tumor nodules and is prominently expressed in the hepatic tumors developed in the aged MKO-hep mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3D3;Q6KAP8;Q6NVB6;Q80XP4", "ec_number_list": "", "go_molecular_function": "GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity", "go_cellular_component": "", "go_biological_process": "GO:0006048 UDP-N-acetylglucosamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TW96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UVR3-1", "uniprot_id": "TTBK2_MOUSE", "mass": 136770.0, "length": 1243, "protein_name": "Tau-tubulin kinase 2", "gene_name": "Ttbk2", "organism": "Mouse", "refseq_name": "tau-tubulin kinase 2 isoform 2", "refseq_ac": "NP_001020027", "gene_names_uniprotkb": "Ttbk2; Bby; Kiaa0847; Ttbk1", "gene_names_refseq": "2610507N02Rik; B930008N24Rik; TTK; Ttbk1; Ttbk2; Ttbk; mKIAA0847", "protein_names_uniprotkb": "Tau-tubulin kinase 2; 2.7.11.1; Protein bartleby", "protein_names_refseq": "protein bartleby; tau-tubulin kinase 2 isoform 2", "tax_id": 10090, "disease": "spinocerebellar ataxia 11 (Disease Ontology:DOID:0050961)", "pathway": " (mmu:140810); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11257498;21750661;23141541;29038301", "class_list": "", "function": "Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (By similarity). Required for recruitment of CPLANE2 and INTU to the mother centriole (PubMed:29038301)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AW12;Q3TSR6;Q3UFW0;Q571D1;Q8BKA4;Q924U8", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;3.6.4.10;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.6.5.2;3.6.5.-;2.7.11.39;2.3.1.-;2.7.11.31;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019894 kinesin binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0021681 cerebellar granular layer development;GO:0007165 signal transduction;GO:0030900 forebrain development;GO:0021915 neural tube development;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UVR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0C5-1", "uniprot_id": "UBP48_MOUSE", "mass": 120631.0, "length": 1052, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 48", "gene_name": "Usp48", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 48 isoform 1", "refseq_ac": "NP_570949", "gene_names_uniprotkb": "Usp48; Kiaa4202", "gene_names_refseq": "2810449C13Rik; D330022K21Rik; Usp31; Usp48", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 48; 3.4.19.12; Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48", "protein_names_refseq": "deubiquitinating enzyme 48; ubiquitin carboxyl-terminal hydrolase 48 isoform 1; ubiquitin carboxyl-terminal hydrolase 48; ubiquitin specific protease 31; ubiquitin specific protease 48; ubiquitin thioesterase 48; ubiquitin thiolesterase 48; ubiquitin-specific-processing protease 48", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 85 (Disease Ontology:DOID:0070605)", "pathway": " (mmu:170707); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;36864656", "class_list": "", "function": "Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. In the context of H.pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death. Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms. Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination., [UniProtKB, UniProtKB]; USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM39;Q571J9;Q8VDJ1", "ec_number_list": "2.3.2.27;3.4.19.12", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V0C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SWD9-1", "uniprot_id": "TSR1_MOUSE", "mass": 92105.0, "length": 803, "protein_name": "Pre-rRNA-processing protein TSR1 homolog", "gene_name": "Tsr1", "organism": "Mouse", "refseq_name": "pre-rRNA-processing protein TSR1 homolog", "refseq_ac": "NP_796299", "gene_names_uniprotkb": "Tsr1; Kiaa1401", "gene_names_refseq": "Tsr1; mKIAA1401", "protein_names_uniprotkb": "Pre-rRNA-processing protein TSR1 homolog", "protein_names_refseq": "TSR1, 20S rRNA accumulation, homolog; pre-rRNA-processing protein TSR1 homolog", "tax_id": 10090, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040)", "pathway": " (mmu:104662); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "19224205;20173027;21750661;25428506;25428507;25605945;30084848;30779550;34428180;34887587;35820727;37828378", "class_list": "", "function": "Required during maturation of the 40S ribosomal subunit in the nucleolus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMW6;Q3TRK6;Q3U4T2;Q3UYU4;Q3V3X8;Q6ZPR9;Q8K2F5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5SWD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61241-1", "uniprot_id": "TSSK1_MOUSE", "mass": 41589.0, "length": 365, "protein_name": "Testis-specific serine/threonine-protein kinase 1", "gene_name": "Tssk1b", "organism": "Mouse", "refseq_name": "testis-specific serine/threonine-protein kinase 1", "refseq_ac": "NP_033461", "gene_names_uniprotkb": "Tssk1b; Stk22a; Tssk1", "gene_names_refseq": "Stk22a; TSK-1; Tsk1; Tssk1b; Tssk1; Tssk", "protein_names_uniprotkb": "Testis-specific serine/threonine-protein kinase 1; 2.7.11.1; Serine/threonine-protein kinase 22A; TSK-1; TSK1; TSSK-1; Testis-specific kinase 1", "protein_names_refseq": "TSSK-1; serine/threonine kinase 22A (spermiogenesis associated); serine/threonine-protein kinase 22A; testis-specific kinase 1; testis-specific serine/threonine kinase; testis-specific serine/threonine-protein kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22114)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10781952;18533145;20053632;20729278;22855445;23599433;24088291;8112611;9412477;9651519", "class_list": "", "function": "HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation, [RefSeq, PubMed]; In mouse testis, PPP1CC2 can form a complex with TSSK1 mediated by the direct interaction of each with the kinase substrate protein TSKS. Interaction between PPP1CC2 and TSKS is mediated through an RVxF docking motif on the TSKS surface. Publication Status: Online-Only, [RefSeq, PubMed]; Testis-specific serine/threonine-protein kinase required during spermatid development (PubMed:20053632, PubMed:23599433). Phosphorylates 'Ser-281' of TSKS (PubMed:20053632). Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm (PubMed:20053632). During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (PubMed:20053632)., [UniProtKB, PubMed, PubMed]; Tssk1 and Tssk2 play an important role in the regulation of sperm function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YU1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0031514 motile cilium;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61241-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62283-1", "uniprot_id": "TSN7_MOUSE", "mass": 27544.0, "length": 249, "protein_name": "Tetraspanin-7", "gene_name": "Tspan7", "organism": "Mouse", "refseq_name": "tetraspanin-7", "refseq_ac": "NP_062608", "gene_names_uniprotkb": "Tspan7; Mxs1; Tm4sf2", "gene_names_refseq": "1200014P11Rik; A15; Cd231; Mxs1; PE31; TALLA; Tm4sf2; Tspan7", "protein_names_uniprotkb": "Tetraspanin-7; Cell surface glycoprotein A15; PE31; TALLA homolog; Transmembrane 4 superfamily member 2; Tspan-7", "protein_names_refseq": "TALLA homolog; cell surface glycoprotein A15; tetraspanin-7; transmembrane 4 superfamily member 2; tspan-7", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 58 (Disease Ontology:DOID:0112024); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:21912); (R-MMU-416993)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10617319;34407208", "class_list": "", "function": "May be involved in cell proliferation and cell motility., [UniProtKB]; Tetraspanin 7 regulates osteoclast function through association with the RANK/alphavbeta3 integrin complex., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O88429;Q9DBS3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62283-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64707-1", "uniprot_id": "U2AFL_MOUSE", "mass": 51364.0, "length": 428, "protein_name": "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2-like", "gene_name": "Zrsr2-ps1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zrsr2-ps1; Sp2-7; Sp2; U2af1-rs1; U2af1l1; Zrsr1", "gene_names_refseq": "", "protein_names_uniprotkb": "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2-like; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1; SP2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1; U2(RNU2) small nuclear RNA auxiliary factor 1-like 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10679248;21183079;29617656;7870588;8136831;8284201", "class_list": "", "function": "Plays a role in splicing of the U12-type introns (PubMed:29617656). Implicated also in removal of U2 introns positioned adjacent to a U12 intron (PubMed:29617656)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0030628 pre-mRNA 3'-splice site binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex;GO:0089701 U2AF complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JW3-1", "uniprot_id": "TOX_MOUSE", "mass": 57203.0, "length": 526, "protein_name": "Thymocyte selection-associated high mobility group box protein TOX", "gene_name": "Tox", "organism": "Mouse", "refseq_name": "thymocyte selection-associated high mobility group box protein TOX", "refseq_ac": "NP_663757", "gene_names_uniprotkb": "Tox", "gene_names_refseq": "1700007F02Rik; Tox", "protein_names_uniprotkb": "Thymocyte selection-associated high mobility group box protein TOX; Thymus high mobility group box protein TOX", "protein_names_refseq": "thymocyte selection-associated HMG box; thymocyte selection-associated high mobility group box protein TOX; thymus high mobility group box protein TOX", "tax_id": 10090, "disease": "", "pathway": " (mmu:252838)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11850626;15078895;18195075;20818394;25527292;25605945;25915732;30084848;30779550;31207603;31207604;39245681", "class_list": "", "function": "TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (PubMed:11850626, PubMed:15078895, PubMed:18195075, PubMed:20818394, PubMed:25527292, PubMed:25915732). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA (PubMed:25527292, PubMed:31207603, PubMed:31207604). During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (PubMed:25527292). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches (PubMed:20818394). Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment (PubMed:11850626, PubMed:18195075). Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells (PubMed:15078895, PubMed:18195075). Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage (PubMed:25915732). Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:20818394). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (PubMed:31207603, PubMed:31207604)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKH9;Q8BYQ5;Q8R4H0", "ec_number_list": "", "go_molecular_function": "GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment;GO:1902232 regulation of positive thymic T cell selection;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q66JW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q673H1-1", "uniprot_id": "TUSC1_MOUSE", "mass": 22712.0, "length": 205, "protein_name": "Tumor suppressor candidate gene 1 protein homolog", "gene_name": "Tusc1", "organism": "Mouse", "refseq_name": "tumor suppressor candidate gene 1 protein homolog", "refseq_ac": "NP_081230", "gene_names_uniprotkb": "Tusc1", "gene_names_refseq": "2200001D17Rik; TSG-9; Tusc1", "protein_names_uniprotkb": "Tumor suppressor candidate gene 1 protein homolog", "protein_names_refseq": "tumor suppressor candidate gene 1 protein homolog; tumour suppressor candidate 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69136)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15208665", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVE2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q673H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P8X6-1", "uniprot_id": "UBP50_MOUSE", "mass": 44543.0, "length": 390, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 50", "gene_name": "Usp50", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 50", "refseq_ac": "NP_083439", "gene_names_uniprotkb": "Usp50", "gene_names_refseq": "1700086G18Rik; 4930511O11Rik; Usp50", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 50; 3.4.19.12; Deubiquitinating enzyme 50; Ubiquitin thioesterase 50; Ubiquitin-specific-processing protease 50", "protein_names_refseq": "deubiquitinating enzyme 50; putative ubiquitin carboxyl-terminal hydrolase 50; ubiquitin carboxyl-terminal hydrolase 50; ubiquitin specific protease 50; ubiquitin thioesterase 50; ubiquitin thiolesterase 50; ubiquitin-specific-processing protease 50", "tax_id": 10090, "disease": "", "pathway": " (mmu:75083)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28094437;38469295", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein. Regulates the ubiquitination and stability of the ACE2 protein. Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway, [RefSeq, PubMed]; USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D558;Q9D9E7", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0019783 ubiquitin-like protein peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0032741 positive regulation of interleukin-18 production;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0007265 Ras protein signal transduction;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P8X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAM1-1", "uniprot_id": "TXLNA_MOUSE", "mass": 62369.0, "length": 554, "protein_name": "Alpha-taxilin", "gene_name": "Txlna", "organism": "Mouse", "refseq_name": "alpha-taxilin", "refseq_ac": "NP_001005506", "gene_names_uniprotkb": "Txlna; Txln", "gene_names_refseq": "2600010N21Rik; Il14; Txlna; Txln", "protein_names_uniprotkb": "Alpha-taxilin", "protein_names_refseq": "alpha-taxilin; interleukin 14; taxilin Txln", "tax_id": 10090, "disease": "", "pathway": " (mmu:109658); (R-MMU-449836)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19663695;21183079;21750661;25153642;26494466;28135057;28528544;31219806;32840323;34428180", "class_list": "", "function": "Analysis of a novel monoclonal antibody against interleukin-14alpha, [RefSeq, PubMed]; May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells., [UniProtKB]; Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway., [RefSeq, PubMed]; The TXLNA may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs in response to testicular injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1E5", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042113 B cell activation;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6PAM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VM3-1", "uniprot_id": "TTC29_MOUSE", "mass": 54282.0, "length": 471, "protein_name": "Tetratricopeptide repeat protein 29", "gene_name": "Ttc29", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ttc29", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 29; TPR repeat protein 29", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 42 (Disease Ontology:DOID:0111923)", "pathway": " (mmu:73301)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31735292;31735294;39066891", "class_list": "", "function": "Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF30", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005737 cytoplasm", "go_biological_process": "GO:0003341 cilium movement;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80VM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WR1-1", "uniprot_id": "TSN18_MOUSE", "mass": 27801.0, "length": 248, "protein_name": "Tetraspanin-18", "gene_name": "Tspan18", "organism": "Mouse", "refseq_name": "tetraspanin-18", "refseq_ac": "NP_899003", "gene_names_uniprotkb": "Tspan18", "gene_names_refseq": "2610042G18Rik; 6720430O15; Tspan18", "protein_names_uniprotkb": "Tetraspanin-18; Tspan-18", "protein_names_refseq": "tetraspanin-18; tspan-18", "tax_id": 10090, "disease": "", "pathway": " (mmu:241556)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20485683;30573509;31599954;32447449", "class_list": "", "function": "Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli., [UniProtKB, PubMed]; The findings identify Tspan18 as a novel regulator of endothelial cell Orai1/Ca2+ signaling and von Willebrand factor release in response to inflammatory stimuli., [RefSeq, PubMed]; Tspan18 is a novel regulator of thrombo-inflammation. Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1990778 protein localization to cell periphery;GO:0006954 inflammatory response;GO:0007599 hemostasis;GO:0017156 calcium-ion regulated exocytosis;GO:1903670 regulation of sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80WR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810A3-1", "uniprot_id": "TTC9C_MOUSE", "mass": 19998.0, "length": 171, "protein_name": "Tetratricopeptide repeat protein 9C", "gene_name": "Ttc9c", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 9C", "refseq_ac": "NP_081688", "gene_names_uniprotkb": "Ttc9c", "gene_names_refseq": "2210019E14Rik; 6330408J23Rik; Ttc9c", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 9C; TPR repeat protein 9C", "protein_names_refseq": "TPR repeat protein 9C; tetratricopeptide repeat protein 9C", "tax_id": 10090, "disease": "", "pathway": " (mmu:70387)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "31219806;34203471;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7W8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q810A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKT6-1", "uniprot_id": "TSN12_MOUSE", "mass": 35408.0, "length": 305, "protein_name": "Tetraspanin-12", "gene_name": "Tspan12", "organism": "Mouse", "refseq_name": "tetraspanin-12 isoform 1", "refseq_ac": "NP_766595", "gene_names_uniprotkb": "Tspan12; Tm4sf12", "gene_names_refseq": "9030619E17; Tm4sf12; Tspan12", "protein_names_uniprotkb": "Tetraspanin-12; Transmembrane 4 superfamily member 12; Tspan-12", "protein_names_refseq": "tetraspanin-12 isoform 1; transmembrane 4 superfamily member 12", "tax_id": 10090, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); exudative vitreoretinopathy 5 (Disease Ontology:DOID:0111408)", "pathway": " (mmu:269831)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19837033;21750661;25428506;28302484;30084848;30354230;34428180", "class_list": "", "function": "Data indicate that Norrin multimers and TSPAN12 cooperatively promote multimerization of FZD4 and its associated proteins to elicit physiological levels of signaling., [RefSeq, PubMed]; Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1)., [UniProtKB, PubMed]; TSPAN12 functions in endothelial cells to promote vascular morphogenesis and blood-retinal barrier formation in developing mice and BRB maintenance in adult mice., [RefSeq, PubMed]; TSPAN12 promotes chemoresistance and proliferation of small cell lung carcinoma under the regulation of miR-495., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1C3;Q8BZU1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0010842 retina layer formation;GO:0045765 regulation of angiogenesis;GO:0035633 maintenance of blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BKT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTV1-1", "uniprot_id": "TUSC3_MOUSE", "mass": 39548.0, "length": 347, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3", "gene_name": "Tusc3", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 isoform 1 precursor", "refseq_ac": "NP_084530", "gene_names_uniprotkb": "Tusc3; N33", "gene_names_refseq": "N33; Tusc3", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3; Magnesium uptake/transporter TUSC3; Oligosaccharyl transferase subunit TUSC3; Protein N33; Tumor suppressor candidate 3", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 isoform 1 precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3; magnesium uptake/transporter TUSC3; oligosaccharyl transferase subunit TUSC3; putative prostate cancer tumor suppressor", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 7 (Disease Ontology:DOID:0081183); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104)", "pathway": " (mmu:80286); (R-MMU-5223345); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;31219806;34428180", "class_list": "glycogene", "function": "Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity;GO:0062062 oligosaccharyltransferase complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0015693 magnesium ion transport;GO:1903830 magnesium ion transmembrane transport;GO:0050890 cognition;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BTV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUH1-1", "uniprot_id": "TXN4B_MOUSE", "mass": 17020.0, "length": 149, "protein_name": "Thioredoxin-like protein 4B", "gene_name": "Txnl4b", "organism": "Mouse", "refseq_name": "thioredoxin-like protein 4B", "refseq_ac": "NP_783577", "gene_names_uniprotkb": "Txnl4b", "gene_names_refseq": "D530025J19Rik; DLP; Dim2; Txnl4b", "protein_names_uniprotkb": "Thioredoxin-like protein 4B", "protein_names_refseq": "thioredoxin-like protein 4B", "tax_id": 10090, "disease": "", "pathway": " (mmu:234723)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;34428180", "class_list": "", "function": "Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KF0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0005682 U5 snRNP", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BUH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWR4-1", "uniprot_id": "UBP40_MOUSE", "mass": 139952.0, "length": 1235, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 40", "gene_name": "Usp40", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 40 isoform 2", "refseq_ac": "NP_001028463", "gene_names_uniprotkb": "Usp40", "gene_names_refseq": "B230215L03Rik; C730029K03; Usp40", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 40; 3.4.19.12; Deubiquitinating enzyme 40; Ubiquitin thioesterase 40; Ubiquitin-specific-processing protease 40", "protein_names_refseq": "deubiquitinating enzyme 40; ubiquitin carboxyl-terminal hydrolase 40 isoform 2; ubiquitin carboxyl-terminal hydrolase 40; ubiquitin specific protease 40; ubiquitin thioesterase 40; ubiquitin thiolesterase 40; ubiquitin-specific-processing protease 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:227334)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21750661;22872234;25428506;35605301;35820727;38307937", "class_list": "", "function": "Deubiquitinating enzyme that plays a key role in maintaining endothelial cell (EC) barrier integrity and regulating apoptosis and inflammation. Stabilizes Claudin-1/CLDN1 by cleaving its polyubiquitin chains, thereby protecting tight junction structure. Prevents EC barrier disruption by inhibiting RhoA activation and reducing phosphorylation of myosin light chain and cofilin. Suppresses EC inflammation by inhibiting NF-kappa-B activation, decreasing ICAM1 expression, and reducing leukocyte adhesion to ECs. Mediates these protective effects in part via deubiquitination and inactivation of heat shock protein 90-beta/HSP90AB1. Targets CFLAR for 'Lys-48'-linked deubiquitination, stabilizing its protein levels. This interaction is facilitated by the adapter protein GMEB1, which enhances USP40-CFLAR binding. Through CFLAR stabilization, USP40 inhibits pro-caspase-8 activation and protects against apoptosis (By similarity). Additionally, USP40 stabilizes HINT1, an activator of p53/TP53, thereby maintaining p53/TP53 levels and sustaining the HINT1-p53/TP53 axis (By similarity)., [UniProtKB, UniProtKB]; The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90beta., [RefSeq, PubMed]; USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EB7;Q148V0;Q3TLV1;Q3TMN0;Q3V1R4;Q5EBN6", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0043066 negative regulation of apoptotic process;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BWR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYG0-1", "uniprot_id": "TTC24_MOUSE", "mass": 36701.0, "length": 334, "protein_name": "Tetratricopeptide repeat protein 24", "gene_name": "Ttc24", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 24", "refseq_ac": "NP_766114", "gene_names_uniprotkb": "Ttc24", "gene_names_refseq": "A430025D11Rik; Ttc24", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 24; TPR repeat protein 24", "protein_names_refseq": "TPR repeat protein 24; tetratricopeptide repeat protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:214191)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPM2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BYG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C159-1", "uniprot_id": "TTC22_MOUSE", "mass": 63101.0, "length": 568, "protein_name": "Tetratricopeptide repeat protein 22", "gene_name": "Ttc22", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 22", "refseq_ac": "NP_808335", "gene_names_uniprotkb": "Ttc22", "gene_names_refseq": "4732467L16Rik; Ttc22", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 22; TPR repeat protein 22", "protein_names_refseq": "TPR repeat protein 22; tetratricopeptide repeat protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:230576)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4B4-1", "uniprot_id": "U119B_MOUSE", "mass": 28303.0, "length": 251, "protein_name": "Protein unc-119 homolog B", "gene_name": "Unc119b", "organism": "Mouse", "refseq_name": "protein unc-119 homolog B", "refseq_ac": "NP_780561", "gene_names_uniprotkb": "Unc119b", "gene_names_refseq": "Unc119b", "protein_names_uniprotkb": "Protein unc-119 homolog B", "protein_names_refseq": "protein unc-119 homolog B; unc-119 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:106840); (R-MMU-5624138)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "23806337;25428507;25605945;34428180;35820727;35984892;37828378", "class_list": "", "function": "Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BY8;Q8BRC4;Q922B4", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005929 cilium;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0007399 nervous system development;GO:0042953 lipoprotein transport;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C4B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C838-1", "uniprot_id": "TARG1_MOUSE", "mass": 18719.0, "length": 173, "protein_name": "Trafficking regulator of GLUT4 1", "gene_name": "Trarg1", "organism": "Mouse", "refseq_name": "trafficking regulator of GLUT4 1", "refseq_ac": "NP_808377", "gene_names_uniprotkb": "Trarg1; Tusc5", "gene_names_refseq": "C130069F04Rik; DSPB1; Lost1; Trarg1; Tusc5", "protein_names_uniprotkb": "Trafficking regulator of GLUT4 1; DSPB1; Dispanin subfamily B member 1; Tumor suppressor candidate 5 homolog", "protein_names_refseq": "dispanin subfamily B member 1; trafficking regulator of GLUT4 1; tumor suppressor candidate 5 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:237858)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17689857;22363774;26240143;26629404;29787242", "class_list": "", "function": "Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation., [UniProtKB, PubMed, PubMed]; The study uses a combination of bioinformatics prediction tools and biochemical assays to define the membrane topology of the 173-amino acid mouse TRARG1. These analyses revealed that, contrary to the consensus prediction, the N-terminus is cytosolic and that a short segment at the C-terminus resides in the luminal/extracellular space., [RefSeq, PubMed]; These findings may point to participation of Tusc5 in shared adipose-nervous system functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane;GO:0044381 glucose import in response to insulin stimulus;GO:0099638 endosome to plasma membrane protein transport;GO:0099500 vesicle fusion to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C838-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CA03-1", "uniprot_id": "S46A2_MOUSE", "mass": 52083.0, "length": 479, "protein_name": "Solute carrier family 46 member 2", "gene_name": "Slc46a2", "organism": "Mouse", "refseq_name": "solute carrier family 46 member 2", "refseq_ac": "NP_066395", "gene_names_uniprotkb": "Slc46a2; Tscot", "gene_names_refseq": "5430429N04Rik; Ly110; Slc46a2; TSO-1C12; Tscot", "protein_names_uniprotkb": "Solute carrier family 46 member 2; Thymic stromal cotransporter homolog", "protein_names_refseq": "putative thymic stromal co-transporter TSCOT; solute carrier family 46 member 2; thymic stromal cotransporter homolog; thymic stromal cotransporter protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:30936)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10706709;10978518;18684012;23178972;26013383;28539433;34235268;34428180;37116499", "class_list": "", "function": "Expression profiling of thymic stromal cotransporter (TSCOT), Slc46A2/Ly110, that was shown to be expressed in bipotent precursor and cortical thymic epithelial cells., [RefSeq, PubMed]; Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury (PubMed:28539433, PubMed:34235268, PubMed:37116499). Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process (PubMed:28539433, PubMed:37116499). To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses (PubMed:28539433). Postulated to function as an importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable)., [UniProtKB, PubMed, PubMed, PubMed]; The introduction of a neoantigen into TSCOT-expressing cells can efficiently establish complete tolerance and suggest a possible application for the deletion of antigen-specific T cells by antigen introduction into TSCOT+ cells., [RefSeq, PubMed]; Thymic epithelial requirement for gammadelta T cell development revealed in the cell ablation transgenic system with TSCOT promoter, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ANT4;Q9D3J2;Q9JLQ3", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0140360 cyclic-GMP-AMP transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0055085 transmembrane transport;GO:0045580 regulation of T cell differentiation;GO:0048538 thymus development;GO:0043029 T cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CA03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CD92-1", "uniprot_id": "TTC27_MOUSE", "mass": 96431.0, "length": 847, "protein_name": "Tetratricopeptide repeat protein 27", "gene_name": "Ttc27", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 27", "refseq_ac": "NP_690030", "gene_names_uniprotkb": "Ttc27", "gene_names_refseq": "2610511O17Rik; Ttc27", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 27; TPR repeat protein 27", "protein_names_refseq": "TPR repeat protein 27; tetratricopeptide repeat protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:74196)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30779550;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THU0;Q8C7S8;Q8K1D9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CD92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHY7-1", "uniprot_id": "TTC23_MOUSE", "mass": 54608.0, "length": 488, "protein_name": "Tetratricopeptide repeat protein 23", "gene_name": "Ttc23", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 23 isoform 2", "refseq_ac": "NP_001161947", "gene_names_uniprotkb": "Ttc23", "gene_names_refseq": "1600012K10Rik; Ttc23", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 23; TPR repeat protein 23", "protein_names_refseq": "TPR repeat protein 23; tetratricopeptide repeat protein 23 isoform 2; tetratricopeptide repeat protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:67009)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;29459677;31219806;34428180", "class_list": "", "function": "Participates positively in the ciliary Hedgehog (Hh) signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAY3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CHY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3A2-1", "uniprot_id": "TRPT1_MOUSE", "mass": 27354.0, "length": 249, "protein_name": "tRNA 2'-phosphotransferase 1", "gene_name": "Trpt1", "organism": "Mouse", "refseq_name": "tRNA 2'-phosphotransferase 1", "refseq_ac": "NP_705825", "gene_names_uniprotkb": "Trpt1; Tpt1h", "gene_names_refseq": "Gm35838; Tpt1h; Tpt1; Trpt1", "protein_names_uniprotkb": "tRNA 2'-phosphotransferase 1; 2.7.1.160; mTPT1", "protein_names_refseq": "EST-MNCb3719; mTPT1; tRNA 2'-phosphotransferase 1; tRNA splicing 2' phosphotransferase 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:107328)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18094117;30084848;31219806;37334830;9826666", "class_list": "", "function": "Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate., [UniProtKB, PubMed]; Inactivation of the Trpt1 gene, encoding the only known mammalian homolog of Tpt1p, eliminates all detectable 2'-phosphotransferase activity from cultured mouse cells but has no measurable effect on spliced Xbp-1 translation., [RefSeq, PubMed]; Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.160", "go_molecular_function": "GO:0000215 tRNA 2'-phosphotransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K3A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0K2-1", "uniprot_id": "TRI31_MOUSE", "mass": 57127.0, "length": 507, "protein_name": "E3 ubiquitin-protein ligase TRIM31", "gene_name": "Trim31", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM31", "refseq_ac": "NP_666189", "gene_names_uniprotkb": "Trim31", "gene_names_refseq": "HCG1; HCGI; RNF; Trim31", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM31; 2.3.2.27; Tripartite motif-containing protein 31", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM31; RING-type E3 ubiquitin transferase TRIM31; tripartite motif-containing protein 31", "tax_id": 10090, "disease": "", "pathway": " (mmu:224762)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19665990;27929086;27992402;30059200;35985421;36597090;38918620;38981220", "class_list": "", "function": "E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (PubMed:19665990)., [UniProtKB, PubMed, PubMed, PubMed]; TRIM31 attenuates c-Src signaling via p52(Shc) under anchorage-independent growth conditions and is potentially associated with growth activity of cells in the gastrointestinal tract., [RefSeq, PubMed]; The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation in Helicobacter pylori-associated gastritis by regulating ROS and autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis., [RefSeq, PubMed]; This paper identifies TRIM31, an E3 ubiquitin ligase of the TRIM family of proteins, as a regulator of MAVS aggregation, [RefSeq, PubMed]; Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044546 NLRP3 inflammasome complex assembly;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R0K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1K1-1", "uniprot_id": "UBAC2_MOUSE", "mass": 39057.0, "length": 345, "protein_name": "Ubiquitin-associated domain-containing protein 2", "gene_name": "Ubac2", "organism": "Mouse", "refseq_name": "ubiquitin-associated domain-containing protein 2 precursor", "refseq_ac": "NP_081137", "gene_names_uniprotkb": "Ubac2; Phgdhl1", "gene_names_refseq": "1190008A14Rik; Phgdhl1; Ubac2", "protein_names_uniprotkb": "Ubiquitin-associated domain-containing protein 2; Phosphoglycerate dehydrogenase-like protein 1; UBA domain-containing protein 2", "protein_names_refseq": "UBA domain-containing protein 2; phosphoglycerate dehydrogenase like 1; phosphoglycerate dehydrogenase-like protein 1; ubiquitin-associated domain-containing protein 2 precursor; ubiquitin-associated domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68889)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;31073040;31219806;34428180", "class_list": "", "function": "Acts as an ER-phagy receptor required for the selective autophagic degradation of endoplasmic reticulum (ER) fragments to maintain ER homeostasis and restrain ER stress-induced inflammatory responses (By similarity). Its function depends on phosphorylation-induced dimerization, which enhances interaction with GABARAP and facilitates recruitment of ER fragments to autophagosomes (By similarity). Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWC0", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0070972 protein localization to endoplasmic reticulum;GO:1904153 negative regulation of retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R1K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PG6-1", "uniprot_id": "TS1R1_MOUSE", "mass": 93426.0, "length": 842, "protein_name": "Taste receptor type 1 member 1", "gene_name": "Tas1r1", "organism": "Mouse", "refseq_name": "taste receptor type 1 member 1 precursor", "refseq_ac": "NP_114073", "gene_names_uniprotkb": "Tas1r1; Gpr70; T1r1; Tr1", "gene_names_refseq": "Gpr70; T1r1; TR1; Tas1r1", "protein_names_uniprotkb": "Taste receptor type 1 member 1; G protein-coupled receptor 70", "protein_names_refseq": "G-protein coupled receptor 70; candidate taste receptor T1R1; taste receptor type 1 member 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:110326); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11178737;11319557;11509186;11894099;12892531;31016494;35968935;37539767", "class_list": "", "function": "Ablation of Tas1r1 Reduces Lipid Accumulation Through Reducing the de Novo Lipid Synthesis and Improving Lipid Catabolism in Mice., [RefSeq, PubMed]; Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease., [RefSeq, PubMed]; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses., [UniProtKB, PubMed]; Tas1r3 knockout leads to reduction in the size of pancreatic islets and their density in pancreatic tissue., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS58;Q923J9;Q925I5;Q99PG5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050916 sensory perception of sweet taste;GO:0050917 sensory perception of umami taste", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99PG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PQ2-1", "uniprot_id": "TRI11_MOUSE", "mass": 52580.0, "length": 467, "protein_name": "E3 ubiquitin-protein ligase TRIM11", "gene_name": "Trim11", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM11 isoform 1", "refseq_ac": "NP_001277917", "gene_names_uniprotkb": "Trim11", "gene_names_refseq": "Trim11", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM11; 2.3.2.27; Tripartite motif-containing protein 11", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM11 isoform 1; E3 ubiquitin-protein ligase TRIM11; RING-type E3 ubiquitin transferase TRIM11; tripartite motif-containing protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:94091); (R-MMU-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11331580;12670303;18248090;18275850;18628401;21750661;27498865;37804507;38718254", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (PubMed:18628401). Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (PubMed:18628401). May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (PubMed:18628401). May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (PubMed:12670303). Mediates MED15 ubiquitination leading to proteasomal degradation (By similarity). May contribute to the innate restriction of retroviruses (PubMed:18248090). Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090). Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090). May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090). Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (By similarity). Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2., [RefSeq, PubMed]; TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction., [RefSeq, PubMed]; TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy., [RefSeq, PubMed]; The results suggest that TRIM11 plays a role in the regulation of intracellular humanin level through ubiquitin-mediated protein degradation pathways., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A868;A2AB84;Q3TCL5;Q8VDX5", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008134 transcription factor binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0045892 negative regulation of DNA-templated transcription;GO:0046598 positive regulation of viral entry into host cell", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99PQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CSP9-5", "uniprot_id": "TTC14_MOUSE", "mass": 87363.0, "length": 766, "protein_name": "Tetratricopeptide repeat protein 14", "gene_name": "Ttc14", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 14 isoform c", "refseq_ac": "NP_001277429", "gene_names_uniprotkb": "Ttc14; Kiaa1980", "gene_names_refseq": "2700016E08Rik; 4930434D01Rik; 4931403I22Rik; 4933402I15Rik; Ttc14; cI-44; mKIAA1980", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 14; TPR repeat protein 14", "protein_names_refseq": "TPR repeat protein 14; tetratricopeptide repeat protein 14 isoform c; tetratricopeptide repeat protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:67120)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X9T5;Q69Z51;Q8BRX6;Q8CD24;Q8CDF8;Q8R3Q9", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CSP9-5", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0C4-1", "uniprot_id": "TRM5_MOUSE", "mass": 56794.0, "length": 501, "protein_name": "tRNA (guanine(37)-N(1))-methyltransferase", "gene_name": "Trmt5", "organism": "Mouse", "refseq_name": "tRNA (guanine(37)-N(1))-methyltransferase isoform 1", "refseq_ac": "NP_083856", "gene_names_uniprotkb": "Trmt5; Kiaa1393; Trm5", "gene_names_refseq": "2610027O18Rik; Trmt5; mKIAA1393", "protein_names_uniprotkb": "tRNA (guanine(37)-N(1))-methyltransferase; 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5 homolog", "protein_names_refseq": "M1G-methyltransferase; TRM5 tRNA methyltransferase 5 homolog; tRNA (guanine(37)-N(1))-methyltransferase isoform 1; tRNA (guanine(37)-N(1))-methyltransferase; tRNA (guanine(37)-N1)-methyltransferase; tRNA (guanine-N(1)-)-methyltransferase; tRNA [GM37] methyltransferase", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); combined oxidative phosphorylation deficiency 26 (Disease Ontology:DOID:0111490); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); hypercalcemia (Disease Ontology:DOID:12678); lactic acidosis (Disease Ontology:DOID:3650); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (mmu:76357)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;32294408", "class_list": "", "function": "Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides., [RefSeq, PubMed]; Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTY1", "ec_number_list": "2.1.1.228", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0002939 tRNA N1-guanine methylation;GO:0070901 mitochondrial tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2M8-1", "uniprot_id": "UB2V2_MOUSE", "mass": 16367.0, "length": 145, "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2", "gene_name": "Ube2v2", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 variant 2 isoform 2", "refseq_ac": "NP_001152823", "gene_names_uniprotkb": "Ube2v2; Mms2; Uev2", "gene_names_refseq": "1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; MMS2; Ube2v2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 variant 2; Ubc-like protein MMS2", "protein_names_refseq": "methyl methanesulfonate sensitive 2; ubc-like protein MMS2; ubiquitin-conjugating enzyme E2 variant 2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70620); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-5696395); (R-MMU-69473); (R-MMU-8866654); (R-MMU-983168)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11406273;18362223;21750661;31219806;37507081;39627609;40885482", "class_list": "", "function": "Ang II type 2 receptor signaling attenuates DNA damage and consequent vascular senescence at least in part through methyl methanesulfonate sensitive 2 (MMS2) transactivation., [RefSeq, PubMed]; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6X924;Q8BGH6;Q8CE99;Q8K2V7;Q9CYD7;Q9ERI8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031372 UBC13-MMS2 complex", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0043524 negative regulation of neuron apoptotic process;GO:0045739 positive regulation of DNA repair;GO:0051965 positive regulation of synapse assembly;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D2M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D411-1", "uniprot_id": "TSSK4_MOUSE", "mass": 37377.0, "length": 328, "protein_name": "Testis-specific serine/threonine-protein kinase 4", "gene_name": "Tssk4", "organism": "Mouse", "refseq_name": "testis-specific serine/threonine-protein kinase 4 isoform 4", "refseq_ac": "NP_001240818", "gene_names_uniprotkb": "Tssk4; Tssk5", "gene_names_refseq": "1700020B19Rik; 4933424F08Rik; TSK-4; TSSK-4; Tssk4", "protein_names_uniprotkb": "Testis-specific serine/threonine-protein kinase 4; 2.7.11.1; TSK-4; TSSK-4; Testis-specific kinase 4", "protein_names_refseq": "testis-specific kinase 4; testis-specific serine/threonine protein kinase 5 variant alpha; testis-specific serine/threonine protein kinase 5 variant beta; testis-specific serine/threonine protein kinase 5 variant delta; testis-specific serine/threonine protein kinase 5 variant gamma; testis-specific serine/threonine-protein kinase 4 isoform 4; testis-specific serine/threonine-protein kinase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71099)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17927909;20729278;21750661;23054012;23599433;25361759;26940607;26961893;27802388", "class_list": "", "function": "Autophosphorylation at Thr-197 plays a critical role in maintaining Tssk4 kinase activity, which might be involved in spermiogenesis., [RefSeq, PubMed]; Catalytically inactive., [UniProtKB, PubMed]; Findings reveal that Tssk4 is required for maintaining the structural integrity of sperm flagellum and male fertility., [RefSeq, PubMed]; HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation, [RefSeq, PubMed]; Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117., [RefSeq, PubMed]; Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (PubMed:17927909, PubMed:23054012, PubMed:23599433, PubMed:25361759, PubMed:26940607). May be involved in the Cre/Creb signaling pathway (PubMed:26940607). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro (PubMed:26940607). Phosphorylates ODF2 on 'Ser-95' (PubMed:26961893)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3QQQ9;A3QQR0;A3QQR1;A9P6P7;A9P6P9;Q9DA58", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0005819 spindle", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0009566 fertilization;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D411-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5S1-1", "uniprot_id": "TX19B_MOUSE", "mass": 35235.0, "length": 317, "protein_name": "Testis-expressed protein 19.2", "gene_name": "Tex19.2", "organism": "Mouse", "refseq_name": "testis-expressed protein 19.2", "refseq_ac": "NP_081898", "gene_names_uniprotkb": "Tex19.2; Tex19b", "gene_names_refseq": "4921530G04Rik; Tex19.2; Tex19b", "protein_names_uniprotkb": "Testis-expressed protein 19.2; Testis-expressed protein 19B", "protein_names_refseq": "testis-expressed protein 19.2; testis-expressed protein 19B; testis-expressed sequence 19B", "tax_id": 10090, "disease": "", "pathway": " (mmu:70956)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18096721;21103378;22447323;25605945;28254886", "class_list": "", "function": "May be required during spermatogenesis, probably by participating in the repression of retrotransposable elements and prevent their mobilization (Probable). With its paralog, Tex19.1, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886)., [UniProtKB, PubMed]; Tex 19 paralogs exhibit a gonad and placenta-specific expression in the mouse, [RefSeq, PubMed]; Tex19 is a mammalian-specific protein duplicated in mouse and rat, renamed Tex19.1 and Tex19.2, whereas only one form is found in human., [RefSeq, PubMed]; This study shows that TEX19 paralogs interact with PIWI proteins and the TEX19 VPTEL domain directly binds Piwi-interacting RNAs in adult testes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034584 piRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0001890 placenta development;GO:0008584 male gonad development;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D5S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6K7-1", "uniprot_id": "TTC33_MOUSE", "mass": 29371.0, "length": 262, "protein_name": "Tetratricopeptide repeat protein 33", "gene_name": "Ttc33", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 33", "refseq_ac": "NP_080489", "gene_names_uniprotkb": "Ttc33", "gene_names_refseq": "2410099M07Rik; 2900001O04Rik; Osrf; Ttc33", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 33; TPR repeat protein 33", "protein_names_refseq": "TPR repeat protein 33; osmosis responsive factor; tetratricopeptide repeat protein 33", "tax_id": 10090, "disease": "", "pathway": " (mmu:67515)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIG5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D6K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D735-1", "uniprot_id": "TRIR_MOUSE", "mass": 18377.0, "length": 173, "protein_name": "Telomerase RNA component-interacting RNase", "gene_name": "Trir", "organism": "Mouse", "refseq_name": "telomerase RNA component interacting RNase", "refseq_ac": "NP_081036", "gene_names_uniprotkb": "Trir", "gene_names_refseq": "1110002H14Rik; 2310036O22Rik; Trir", "protein_names_uniprotkb": "Telomerase RNA component-interacting RNase; 3.1.13.-; Exoribonuclease Trir", "protein_names_refseq": "exoribonuclease TrirR; telomerase RNA component interacting RNase; uncharacterized protein C19orf43 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68544)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23806337;24788674;25428506;28528544", "class_list": "", "function": "Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to cleave all four unpaired RNA nucleotides from the 5' end or 3' end with higher efficiency for purine bases (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1N3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008408 3'-5' exonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "", "go_biological_process": "GO:0016075 rRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA17-1", "uniprot_id": "TSG13_MOUSE", "mass": 32067.0, "length": 273, "protein_name": "Testis-specific gene 13 protein", "gene_name": "Tsga13", "organism": "Mouse", "refseq_name": "testis-specific gene 13 protein", "refseq_ac": "NP_473414", "gene_names_uniprotkb": "Tsga13", "gene_names_refseq": "1700023D02Rik; Tsga13; Vme1", "protein_names_uniprotkb": "Testis-specific gene 13 protein", "protein_names_refseq": "testis-specific gene 13 protein; variegated monoallelic expression 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:116732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DA17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC60-1", "uniprot_id": "UBIA1_MOUSE", "mass": 36684.0, "length": 336, "protein_name": "UbiA prenyltransferase domain-containing protein 1", "gene_name": "Ubiad1", "organism": "Mouse", "refseq_name": "ubiA prenyltransferase domain-containing protein 1", "refseq_ac": "NP_082149", "gene_names_uniprotkb": "Ubiad1", "gene_names_refseq": "1200002M06Rik; Tere1; Ubiad1", "protein_names_uniprotkb": "UbiA prenyltransferase domain-containing protein 1; 2.5.1.-; 2.5.1.39", "protein_names_refseq": "transitional epithelia response protein; ubiA prenyltransferase domain-containing protein 1", "tax_id": 10090, "disease": "lymphoma (Disease Ontology:DOID:0060058); Schnyder corneal dystrophy (Disease Ontology:DOID:0060456)", "pathway": " (mmu:71707); (R-MMU-6806664)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "25127365;29663377;29977031;30084848;31219806;34428180;36411684", "class_list": "", "function": "Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress., [UniProtKB, UniProtKB]; The Ubiad1(N100S) mouse provides a promising animal model of schnyder corneal dystrophy (SCD) revealing that mitochondrial dysfunction is a prominent component of the disease. The different phenotype in human and mouse may due to difference in cholesterol metabolism between species. Publication Status: Online-Only, [RefSeq, PubMed]; UBIAD1 is responsible for vitamin K2 synthesis but may not be responsible for CoQ9 synthesis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; UBIAD1 protects against oxygen-glucose deprivation/reoxygenation injury via nNOS/NO pathway., [RefSeq, PubMed]; UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT Pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AH70;B2KFZ5;Q6IR30;Q8BJX7", "ec_number_list": "2.5.1.39;2.5.1.-", "go_molecular_function": "GO:0016209 antioxidant activity;GO:0004659 prenyltransferase activity;GO:0008412 4-hydroxybenzoate polyprenyltransferase activity;GO:0120566 menadiol geranylgeranyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0072359 circulatory system development;GO:0006744 ubiquinone biosynthetic process;GO:0009234 menaquinone biosynthetic process;GO:0042371 vitamin K biosynthetic process;GO:0001885 endothelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DC60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EP53-1", "uniprot_id": "TSC1_MOUSE", "mass": 128746.0, "length": 1161, "protein_name": "Hamartin", "gene_name": "Tsc1", "organism": "Mouse", "refseq_name": "hamartin isoform 1", "refseq_ac": "NP_001276504", "gene_names_uniprotkb": "Tsc1; Kiaa0243", "gene_names_refseq": "Tsc1", "protein_names_uniprotkb": "Hamartin; Tuberous sclerosis 1 protein homolog", "protein_names_refseq": "hamartin isoform 1; hamartin; tuberous sclerosis 1 protein homolog", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); spinal disease (Disease Ontology:DOID:0060564); anterior segment dysgenesis (Disease Ontology:DOID:0060648); tuberous sclerosis 1 (Disease Ontology:DOID:0080324); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); intellectual disability (Disease Ontology:DOID:1059); tuberous sclerosis (Disease Ontology:DOID:13515); breast cancer (Disease Ontology:DOID:1612); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:64930); (R-MMU-1632852); (R-MMU-165181); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8854214)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "11130985;11438694;12820960;16707451;17114649;21183079;21750661;22517741;22645316;29127155;31219806;32848054;40021952;40885482", "class_list": "", "function": "Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12820960). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12820960). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12820960). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (By similarity). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (PubMed:16707451). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AHW1;Q3UHF2;Q7TS92;Q80U55;Q924U7", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding;GO:0042030 ATPase inhibitor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0033596 TSC1-TSC2 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0051893 regulation of focal adhesion assembly;GO:0036294 cellular response to decreased oxygen levels;GO:0007399 nervous system development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9EP53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJL0-1", "uniprot_id": "TSGA8_MOUSE", "mass": 22769.0, "length": 238, "protein_name": "Testis-specific gene A8 protein", "gene_name": "Tsga8", "organism": "Mouse", "refseq_name": "testis-specific gene A8 protein", "refseq_ac": "NP_068698", "gene_names_uniprotkb": "Tsga8; Halapx", "gene_names_refseq": "Halap-X; Halapx; Tsga8", "protein_names_uniprotkb": "Testis-specific gene A8 protein; Halap-x; Haploid-specific alanine-rich acidic protein located on chromosome X", "protein_names_refseq": "haploid specific alanine rich acidic protein, X chromosome; haploid-specific alanine-rich acidic protein located on chromosome X; testis-specific gene A8 protein; testis-specific protein A8", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:100502723)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10993819;30541061;33766931", "class_list": "", "function": "Details of a regulatory mechanism that includes DNA methylation and transcription factors to mediate the postmeiotic expression of an X-linked gene, Tsga8., [RefSeq, PubMed]; Tsga8 is required for spermatid morphogenesis and male fertility in mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "C4IXT6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007286 spermatid development;GO:0007289 spermatid nucleus differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JME7-1", "uniprot_id": "TPC2L_MOUSE", "mass": 16019.0, "length": 139, "protein_name": "Trafficking protein particle complex subunit 2-like protein", "gene_name": "Trappc2l", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 2-like protein", "refseq_ac": "NP_067477", "gene_names_uniprotkb": "Trappc2l", "gene_names_refseq": "1810017G16Rik; Hspc176; Tca17; Trappc2l", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 2-like protein", "protein_names_refseq": "trafficking protein particle complex 2-like; trafficking protein particle complex subunit 2-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:59005); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10679242;34428180", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUI9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0006901 vesicle coating;GO:0099022 vesicle tethering", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JME7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0M5-1", "uniprot_id": "TPK1_MOUSE", "mass": 27068.0, "length": 243, "protein_name": "Thiamine pyrophosphokinase 1", "gene_name": "Tpk1", "organism": "Mouse", "refseq_name": "thiamine pyrophosphokinase 1 isoform 2", "refseq_ac": "NP_001298040", "gene_names_uniprotkb": "Tpk1", "gene_names_refseq": "Tpk1", "protein_names_uniprotkb": "Thiamine pyrophosphokinase 1; 2.7.6.-; Thiamin pyrophosphokinase 1; mTPK1", "protein_names_refseq": "mTPK1; thiamin pyrophosphokinase 1; thiamine pyrophosphokinase 1 isoform 2; thiamine pyrophosphokinase 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (mmu:29807); (R-MMU-196819)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10567383;11419946;16365036;37828378;38547260", "class_list": "", "function": "Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism (PubMed:38547260). By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis (PubMed:38547260). Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence (PubMed:10567383, PubMed:16365036, PubMed:38547260)., [UniProtKB, PubMed, PubMed, PubMed]; Three-dimensional structure of thiamine pyrophosphokinase crystallized from an equilibrium substrate/product mixture shows clear electron density for pyrithiamine pyrophosphate bound in the enzyme active site., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWB5;Q8CAB5;Q8CEE8;Q8R1Q6", "ec_number_list": "2.7.6.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016301 kinase activity;GO:0004788 thiamine diphosphokinase activity;GO:0030975 thiamine binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0006772 thiamine metabolic process;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R0M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU56-1", "uniprot_id": "PUS1_MOUSE", "mass": 47502.0, "length": 423, "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "Pus1", "organism": "Mouse", "refseq_name": "pseudouridylate synthase 1 homolog isoform 3", "refseq_ac": "NP_001020733", "gene_names_uniprotkb": "Pus1; MNCb-0873", "gene_names_refseq": "A730013B20Rik; MPUS1; Pus1; mPus1p", "protein_names_uniprotkb": "Pseudouridylate synthase 1 homolog; 5.4.99.-; 5.4.99.12; tRNA pseudouridine synthase 1; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I", "protein_names_refseq": "pseudouridylate synthase 1 homolog isoform 3; pseudouridylate synthase 1 homolog; tRNA pseudouridine synthase 1; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I", "tax_id": 10090, "disease": "myopathy, lactic acidosis, and sideroblastic anemia (Disease Ontology:DOID:0080099); myopathy, lactic acidosis, and sideroblastic anemia 1 (Disease Ontology:DOID:0111185)", "pathway": " (mmu:56361)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10094309;11085940;15327771;17170069;21183079;21750661;25428506;27197761;31219806;34428180", "class_list": "", "function": "Collectively, these results suggest that alterations in muscle metabolism related to mitochondrial content and oxidative capacity may account for the reduced exercise capacity in Pus1(-/-) mice. Publication Status: Online-Only, [RefSeq, PubMed]; Does not form pseudouridine when expressed in vitro., [UniProtKB, PubMed]; Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:10094309, PubMed:15327771, PubMed:27197761). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:10094309). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (By similarity). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (By similarity). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (By similarity). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:15327771)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Pus1p- and Pus3p-dependent pseudouridylation of SRA controls a coactivator-corepressor switch in SRA with major consequences for NR signaling., [RefSeq, PubMed]; Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (mRAR)gamma when coexpressed with steroid receptor RNA activator., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUC6;Q791J1;Q8C250;Q8VDQ3;Q9EQD1;Q9JJE5", "ec_number_list": "5.4.99.12;5.4.99.-;5.4.99.42;5.4.99.28;5.4.99.25", "go_molecular_function": "GO:0002153 steroid receptor RNA activator RNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0000049 tRNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008380 RNA splicing;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WU56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0P5-1", "uniprot_id": "TWF2_MOUSE", "mass": 39471.0, "length": 349, "protein_name": "Twinfilin-2", "gene_name": "Twf2", "organism": "Mouse", "refseq_name": "twinfilin-2", "refseq_ac": "NP_036006", "gene_names_uniprotkb": "Twf2; Ptk9l", "gene_names_refseq": "A6-related; Ptk9l; Ptk9r; Twf2", "protein_names_uniprotkb": "Twinfilin-2; A6-related protein; Twinfilin-1-like protein; mA6RP", "protein_names_refseq": "PTK9 protein typrotein tyrosine kinase 9-like (A6-related protein); mA6RP; protein tyrosine kinase 9 related protein; protein tyrosine kinase 9-like (A6-related protein); twinfilin, actin-binding protein, homolog 2; twinfilin-1-like protein; twinfilin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:23999)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10406962;12807912;15592455;18034455;18837697;19774077;19955359;21183079;21750661;21876732;28743718;37507081;37828378", "class_list": "", "function": "Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Twf2a-controlled actin rearrangements dampen platelet activation responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD06;Q3TZG2;Q8BN77;Q9DCK8", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0030027 lamellipodium;GO:0030426 growth cone", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0032956 regulation of actin cytoskeleton organization;GO:0035556 intracellular signal transduction;GO:0071300 cellular response to retinoic acid;GO:0051016 barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z0P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YZF7-1", "uniprot_id": "VS10L_MOUSE", "mass": 91519.0, "length": 868, "protein_name": "V-set and immunoglobulin domain-containing protein 10-like", "gene_name": "Vsig10l", "organism": "Mouse", "refseq_name": "V-set and immunoglobulin domain-containing protein 10-like isoform 1 precursor", "refseq_ac": "NP_001355810", "gene_names_uniprotkb": "Vsig10l", "gene_names_refseq": "Vsig10l", "protein_names_uniprotkb": "V-set and immunoglobulin domain-containing protein 10-like", "protein_names_refseq": "V-set and immunoglobulin domain-containing protein 10-like isoform 1 precursor; V-set and immunoglobulin domain-containing protein 10-like; ZV-set and immunoglobulin domain containing 10 like", "tax_id": 10090, "disease": "", "pathway": " (mmu:75690)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26495903", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D3YWE2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3YZF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40338-1", "uniprot_id": "VHL_MOUSE", "mass": 20770.0, "length": 181, "protein_name": "von Hippel-Lindau disease tumor suppressor", "gene_name": "Vhl", "organism": "Mouse", "refseq_name": "von Hippel-Lindau disease tumor suppressor", "refseq_ac": "NP_033533", "gene_names_uniprotkb": "Vhl; Vhlh", "gene_names_refseq": "Vhlh; Vhl; pVHL", "protein_names_uniprotkb": "von Hippel-Lindau disease tumor suppressor; pVHL", "protein_names_refseq": "von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome protein homolog", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); familial erythrocytosis 2 (Disease Ontology:DOID:0060474); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); von Hippel-Lindau disease (Disease Ontology:DOID:14175); pancreatic cancer (Disease Ontology:DOID:1793); nephroblastoma (Disease Ontology:DOID:2154); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); hepatocellular carcinoma (Disease Ontology:DOID:684); polycythemia (Disease Ontology:DOID:8432); sudden infant death syndrome (Disease Ontology:DOID:9007); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22346); (R-MMU-1234176); (R-MMU-3232142); (R-MMU-8951664); (R-MMU-9706019); (R-MMU-983168)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "21750661;7850784;8521303", "class_list": "", "function": "Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030891 VCB complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042069 regulation of catecholamine metabolic process;GO:0048877 homeostasis of number of retina cells;GO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:2001233 regulation of apoptotic signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P40338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W78-1", "uniprot_id": "USB1_MOUSE", "mass": 30250.0, "length": 267, "protein_name": "U6 snRNA phosphodiesterase 1", "gene_name": "Usb1", "organism": "Mouse", "refseq_name": "U6 snRNA phosphodiesterase 1 isoform 1", "refseq_ac": "NP_598715", "gene_names_uniprotkb": "Usb1; AA960436; USB1", "gene_names_refseq": "Usb1", "protein_names_uniprotkb": "U6 snRNA phosphodiesterase 1; 3'-5' RNA exonuclease USB1; 4.6.1.-", "protein_names_refseq": "3'-5' RNA exonuclease USB1; U6 snRNA phosphodiesterase 1 isoform 1; U6 snRNA phosphodiesterase 1; UPF0406 protein C16orf57 homolog; putative U6 snRNA phosphodiesterase", "tax_id": 10090, "disease": "ablepharon macrostomia syndrome (Disease Ontology:DOID:0060550); poikiloderma with neutropenia (Disease Ontology:DOID:0060551)", "pathway": " (mmu:101985)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU91", "ec_number_list": "3.1.4.-;4.6.1.-", "go_molecular_function": "GO:0016829 lyase activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:1990838 poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends;GO:0016787 hydrolase activity;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045171 intercellular bridge", "go_biological_process": "GO:0008380 RNA splicing;GO:0034477 U6 snRNA 3'-end processing;GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91W78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54775-1", "uniprot_id": "CCN4_MOUSE", "mass": 40703.0, "length": 367, "protein_name": "CCN family member 4", "gene_name": "Ccn4", "organism": "Mouse", "refseq_name": "CCN family member 4 precursor", "refseq_ac": "NP_061353", "gene_names_uniprotkb": "Ccn4; Elm1; Wisp1", "gene_names_refseq": "Ccn4; Elm1; Wisp1", "protein_names_uniprotkb": "CCN family member 4; ELM-1; WISP-1; WNT1-inducible-signaling pathway protein 1", "protein_names_refseq": "CCN family member 4 precursor; CCN family member 4; WNT1 inducible signaling pathway protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22402)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;36370364;36372279;38891121;39033550;9449709;9843955", "class_list": "", "function": "Analysis of CCN4/WISP1 Effects on Joint Tissues Using Gain- and Loss-of-Function Approaches., [RefSeq, PubMed]; Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity). Suppresses tumor growth in vivo., [UniProtKB]; HuR-dependent expression of Wisp1 is necessary for TGFbeta-induced cardiac myofibroblast activity., [RefSeq, PubMed]; The TGF-beta1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects., [RefSeq, PubMed]; WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts' Activation and Collagen Processing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZL1", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0042593 glucose homeostasis;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O54775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIC6-1", "uniprot_id": "V1R51_MOUSE", "mass": 36533.0, "length": 319, "protein_name": "Vomeronasal type-1 receptor 51", "gene_name": "Vmn1r51", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 51", "refseq_ac": "NP_035813", "gene_names_uniprotkb": "Vmn1r51; Pr1; V1ra1; V1ra8", "gene_names_refseq": "V1R; V1r1; V1ra1; VN12; Vmn1r51; mV1R1", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 51; Pheromone receptor 1; Vomeronasal type-1 receptor A1; Vomeronasal type-1 receptor A8; mV1R1", "protein_names_refseq": "pheromone receptor 1; vomeronasal 1 receptor Vmn1r51; vomeronasal 1 receptor, A1; vomeronasal 1, receptor 1; vomeronasal organ family 1, receptor 1; vomeronasal receptor V1RA1; vomeronasal type 1 receptor A1; vomeronasal type-1 receptor 51; vomeronasal type-1 receptor A8", "tax_id": 10090, "disease": "", "pathway": " (mmu:22296)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11116090;11752409;12214233;16731509;21750661;9757043", "class_list": "", "function": "Inputs from neurons in vomeronasal organ expressing closely related V1Rs intermingle within shared, spatially conserved domains of the accessory olfactory bulb (AOB), [RefSeq, PubMed]; Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPA4;Q9Z195", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VIC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51612-1", "uniprot_id": "XPC_MOUSE", "mass": 104522.0, "length": 930, "protein_name": "DNA repair protein complementing XP-C cells homolog", "gene_name": "Xpc", "organism": "Mouse", "refseq_name": "DNA repair protein complementing XP-C cells homolog", "refseq_ac": "NP_033557", "gene_names_uniprotkb": "Xpc", "gene_names_refseq": "Xpc", "protein_names_uniprotkb": "DNA repair protein complementing XP-C cells homolog; Xeroderma pigmentosum group C-complementing protein homolog; p125", "protein_names_refseq": "DNA repair protein complementing XP-C cells homolog; p125; xeroderma pigmentosum group C-complementing protein homolog", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group C (Disease Ontology:DOID:0110844); lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); serous cystadenocarcinoma (Disease Ontology:DOID:3114)", "pathway": " (mmu:22591); (R-MMU-3108214); (R-MMU-5696394); (R-MMU-5696395)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17242355;19144319;21183079;21750661;25428506;7675084;8604333", "class_list": "", "function": "In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes., [UniProtKB, UniProtKB]; Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P54732;Q3TKI2;Q920M1;Q9DBW7", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003684 damaged DNA binding;GO:0044877 protein-containing complex binding;GO:0003697 single-stranded DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000720 pyrimidine dimer repair by nucleotide-excision repair;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006974 DNA damage response;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0G4-1", "uniprot_id": "CCN5_MOUSE", "mass": 27095.0, "length": 251, "protein_name": "CCN family member 5", "gene_name": "Ccn5", "organism": "Mouse", "refseq_name": "CCN family member 5 precursor", "refseq_ac": "NP_058569", "gene_names_uniprotkb": "Ccn5; Ctgfl; Wisp2", "gene_names_refseq": "Ccn5; Crgr4; Ctgfl; Rcop1; Wisp2", "protein_names_uniprotkb": "CCN family member 5; CTGF-L; Connective tissue growth factor-like protein; WISP-2; WNT1-inducible-signaling pathway protein 2", "protein_names_refseq": "CCN family member 5 precursor; CCN family member 5; CTGF-L; WISP-2; WNT1 inducible signaling pathway protein 2; connective tissue growth factor-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:22403)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10358067;21750661;30485307;30571728;32885578;35820727;38892449;9843955", "class_list": "", "function": "Knockout (KO) of CCN5, which encodes a matricellular protein, caused mild obesity. The CCN5 KO mice also exhibited mild diabetes characterized by high fasting glucose levels and impaired insulin and glucose tolerances. Cardiac hypertrophy, ectopic lipid accumulation, and impaired lipid metabolism in hearts were observed in CCN5 KO. Publication Status: Online-Only, [RefSeq, PubMed]; May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling., [RefSeq, PubMed]; These data suggest that down-regulation of CCN5 is associated with fibrotic deformation of Retinal pigment epithelium (RPE) under pathological conditions and that restoration of the CCN5 level effectively promotes recovery of deformed RPE. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIC8", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0045597 positive regulation of cell differentiation;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z0G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A9Z1V5-1", "uniprot_id": "VW5B1_MOUSE", "mass": 133972.0, "length": 1215, "protein_name": "von Willebrand factor A domain-containing protein 5B1", "gene_name": "Vwa5b1", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 5B1 precursor", "refseq_ac": "NP_083677", "gene_names_uniprotkb": "Vwa5b1", "gene_names_refseq": "4931403E03Rik; Vwa5b1", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 5B1", "protein_names_refseq": "von Willebrand factor A domain-containing protein 5B1 precursor; von Willebrand factor A domain-containing protein 5B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75718)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFX4;Q9CUE8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A9Z1V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RUP2-1", "uniprot_id": "UN13D_MOUSE", "mass": 123119.0, "length": 1085, "protein_name": "Protein unc-13 homolog D", "gene_name": "Unc13d", "organism": "Mouse", "refseq_name": "protein unc-13 homolog D", "refseq_ac": "NP_001009573", "gene_names_uniprotkb": "Unc13d", "gene_names_refseq": "2610108D09Rik; Jinx; Munc13-4; Unc13d; mFLJ00067", "protein_names_uniprotkb": "Protein unc-13 homolog D; Munc13-4", "protein_names_refseq": "likely ortholog of H. sapiens unc-13 homolog D (UNC13D); protein unc-13 homolog D", "tax_id": 10090, "disease": "familial hemophagocytic lymphohistiocytosis 3 (Disease Ontology:DOID:0110923)", "pathway": " (mmu:70450); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17242355;17420270;18354201;21183079;21750661;25605945;30084848;31219806;34428180", "class_list": "", "function": "Doc2alpha-Muunc13-4 system regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells, [RefSeq, PubMed]; Hemophagocytic lymphohistiocytosis phenotype is conditional, which suggests the existence of a specific infectious trigger of familial hemophagocytic lymphohistiocytosis in humans Erratum:[J Exp Med. 2008 Mar 17;205(3):737], [RefSeq, PubMed]; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A856;A3R4M4;A3R4M5;Q571J0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0002432 granuloma formation;GO:1903307 positive regulation of regulated secretory pathway;GO:0051607 defense response to virus;GO:0006909 phagocytosis;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B2RUP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFU8-1", "uniprot_id": "VGLU3_MOUSE", "mass": 66148.0, "length": 601, "protein_name": "Vesicular glutamate transporter 3", "gene_name": "Slc17a8", "organism": "Mouse", "refseq_name": "vesicular glutamate transporter 3 isoform 1", "refseq_ac": "NP_892004", "gene_names_uniprotkb": "Slc17a8; Vglut3", "gene_names_refseq": "Slc17a8; Vglut3; Vgt3", "protein_names_uniprotkb": "Vesicular glutamate transporter 3; Solute carrier family 17 member 8; VGluT3", "protein_names_refseq": "solute carrier family 17 member 8; vesicular glutamate transporter 3 isoform 1; vesicular glutamate transporter 3", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); cochlear disease (Disease Ontology:DOID:5463); trichinosis (Disease Ontology:DOID:9784)", "pathway": " (mmu:216227); (R-MMU-442660)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12384506;18080752;18215623;18278042;18674745;21750661;33300544;36852467", "class_list": "", "function": "Cloning and functionally characterization; expressed on synaptic vesicles that identifies a distinct glutamatergic system in the brain that is partly and selectively promiscuous with cholinergic and serotoninergic transmission (VGLUT3), [RefSeq, PubMed]; Loss of Vglut3 caused a hypocholinergic striatal phenotype. In Vglut3(-/-) mice, acetylcholine release was decreased in striatum slices lacking VGLUT3., [RefSeq, PubMed]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:12384506, PubMed:18080752, PubMed:18215623). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12384506, PubMed:18080752, PubMed:18215623). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12384506). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (By similarity). The symporter activity is electrogenic (By similarity). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (PubMed:18278042)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction, [RefSeq, PubMed]; Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity;GO:0140788 L-glutamate uniporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0003407 neural retina development;GO:0050803 regulation of synapse structure or activity;GO:0035249 synaptic transmission, glutamatergic;GO:0007605 sensory perception of sound;GO:0055062 phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BFU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22726-1", "uniprot_id": "WNT5B_MOUSE", "mass": 40343.0, "length": 359, "protein_name": "Protein Wnt-5b", "gene_name": "Wnt5b", "organism": "Mouse", "refseq_name": "protein Wnt-5b precursor", "refseq_ac": "NP_001258686", "gene_names_uniprotkb": "Wnt5b; Wnt-5b", "gene_names_refseq": "Wnt-5b; Wnt5b", "protein_names_uniprotkb": "Protein Wnt-5b", "protein_names_refseq": "protein Wnt-5b precursor; protein Wnt-5b; wingless-related MMTV integration site 5B", "tax_id": 10090, "disease": "leiomyoma (Disease Ontology:DOID:127)", "pathway": " (mmu:22419); (R-MMU-3238698); (R-MMU-4086400)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10866835;21750661;2279700", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91XF5", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0030335 positive regulation of cell migration;GO:0045600 positive regulation of fat cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P22726-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z5L9-1", "uniprot_id": "CCN6_MOUSE", "mass": 39379.0, "length": 354, "protein_name": "Cellular communication network factor 6", "gene_name": "Ccn6", "organism": "Mouse", "refseq_name": "cellular communication network factor 6 precursor", "refseq_ac": "NP_001120848", "gene_names_uniprotkb": "Ccn6; Wisp3", "gene_names_refseq": "Ccn6; Gm735; WISP-3; Wisp3", "protein_names_uniprotkb": "Cellular communication network factor 6; CCN family member 6; WISP-3; WNT1-inducible-signaling pathway protein 3", "protein_names_refseq": "CCN family member 6; WNT1 inducible signaling pathway protein 3; cellular communication network factor 6 precursor", "tax_id": 10090, "disease": "progressive pseudorheumatoid arthropathy of childhood (Disease Ontology:DOID:0090004); arthropathy (Disease Ontology:DOID:381); breast metaplastic carcinoma (Disease Ontology:DOID:4680)", "pathway": " (mmu:327743)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15601861;21921419;29920361", "class_list": "", "function": "Demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin beta1, leading to the phosphorylation of FAK(Y397)., [RefSeq, PubMed]; Plays a role in mitochondrial electron transport and mitochondrial respiration., [UniProtKB, UniProtKB]; The WISP3 gene is essential to skeletal growth or homeostasis in humans but not in mice [WISP3], [RefSeq, PubMed]; WISP-3/CCN6 has a role in inhibiting apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0051881 regulation of mitochondrial membrane potential;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3Z5L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KC8-1", "uniprot_id": "VMA5A_MOUSE", "mass": 87143.0, "length": 793, "protein_name": "von Willebrand factor A domain-containing protein 5A", "gene_name": "Vwa5a", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 5A", "refseq_ac": "NP_001139429", "gene_names_uniprotkb": "Vwa5a; Loh11cr2a", "gene_names_refseq": "5830475I06Rik; BCSC-1; E130119J22; Loh11cr2a; Vwa5a", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 5A; Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog", "protein_names_refseq": "loss of heterozygosity, 11, chromosomal region 2, gene A homolog; von Willebrand factor A domain-containing protein 5A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67776)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;14504409;17947660;20173027;21750661;22645316;25428506;28135057;28528544;30084848;30779550;31219806;31599954;34428180;35820727;37507081;37828378", "class_list": "", "function": "May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTU2;Q3UVU1;Q3V3F2;Q6UN22;Q8BHA8;Q9CTV9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q99KC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79457-1", "uniprot_id": "UTY_MOUSE", "mass": 136737.0, "length": 1212, "protein_name": "Histone demethylase UTY", "gene_name": "Uty", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Uty; Kdm6c", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone demethylase UTY; 1.14.11.68; Male-specific histocompatibility antigen H-YDB; Ubiquitously transcribed TPR protein on the Y chromosome; Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein; [histone H3]-trimethyl-L-lysine(27) demethylase UTY", "protein_names_refseq": "", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:22290); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "10527383;11254691;11313378;11477540;11564792;12393464;12407024;12433366;12649154;14726386;14970182;15314541;15383580;15812391;16818754;17142744;18941186;19951284;21085063;21209285;21750661;21964607;22101894;23636825;24161680;29662488;31599954;34428180;8944031;9736773;9854018;9920845", "class_list": "", "function": "Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low KDM activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O97979", "ec_number_list": "1.14.11.68;1.14.11.65", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0044666 MLL3/4 complex;GO:0032991 protein-containing complex;GO:0005634 nucleus", "go_biological_process": "GO:0086003 cardiac muscle cell contraction;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0003007 heart morphogenesis;GO:0045184 establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P79457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P85442-1", "uniprot_id": "VGLL3_MOUSE", "mass": 35999.0, "length": 326, "protein_name": "Transcription cofactor vestigial-like protein 3", "gene_name": "Vgll3", "organism": "Mouse", "refseq_name": "transcription cofactor vestigial-like protein 3 isoform 1", "refseq_ac": "NP_001355689", "gene_names_uniprotkb": "Vgll3", "gene_names_refseq": "1700110N18Rik; 4832416J22; Vgl-3; Vgll3; Vito-2", "protein_names_uniprotkb": "Transcription cofactor vestigial-like protein 3; Vgl-3", "protein_names_refseq": "transcription cofactor vestigial-like protein 3 isoform 1; transcription cofactor vestigial-like protein 3; vestigial like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73569)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19118645;21750661;23152581;23415753;32782141;34428180;35750933;36754961;37262950", "class_list": "", "function": "In embryonic and fetal development VITO-2 is mainly expressed in the myogenic lineage.Later developmental stages it is found in the nervous system.In adult mice it was detected in skeletal muscle, heart, kidney, liver, brain., [RefSeq, PubMed]; Loss of VGLL3 expression was observed in tumors derived from mouse xenograft models., [RefSeq, PubMed]; May act as a specific coactivator for the mammalian TEFs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; VGLL3 confers slow-twitch muscle differentiation via PGC-1alpha expression in C2C12 myocytes., [RefSeq, PubMed]; VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Publication Status: Online-Only, [RefSeq, PubMed]; Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling., [RefSeq, PubMed]; Vestigial-like 3 (Vgll3) is an inhibitor of adipogenesis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P85442-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q6I0-1", "uniprot_id": "V2116_MOUSE", "mass": 97704.0, "length": 856, "protein_name": "Vomeronasal type-2 receptor 116", "gene_name": "Vmn2r116", "organism": "Mouse", "refseq_name": "vomeronasal type-2 receptor 116 precursor", "refseq_ac": "NP_001098050", "gene_names_uniprotkb": "Vmn2r116; V2rp5", "gene_names_refseq": "EG619697; V2Rp5; Vmn2r116", "protein_names_uniprotkb": "Vomeronasal type-2 receptor 116; Vomeronasal type-2 receptor P5", "protein_names_refseq": "vomeronasal 2 receptor p5; vomeronasal receptor Vmn2r116; vomeronasal type-2 receptor 116 precursor; vomeronasal type-2 receptor 116; vomeronasal type-2 receptor P5", "tax_id": 10090, "disease": "", "pathway": " (mmu:619697)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20596023;21750661;23576433", "class_list": "", "function": "Charge-charge interactions determine the specificity of ESP1 binding to V2Rp5 in the large extracellular region characteristic of class C GPCRs., [RefSeq, PubMed]; ESP1 is recognized by a specific vomeronasal receptor, V2Rp5, and the ligand-receptor interaction results in sex-specific signal transmission to the amygdaloid and hypothalamic nuclei via the accessory olfactory bulb, [RefSeq, PubMed]; Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D7URW5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0045925 positive regulation of female receptivity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q6I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54929-1", "uniprot_id": "WSB2_MOUSE", "mass": 45261.0, "length": 404, "protein_name": "WD repeat and SOCS box-containing protein 2", "gene_name": "Wsb2", "organism": "Mouse", "refseq_name": "WD repeat and SOCS box-containing protein 2", "refseq_ac": "NP_067514", "gene_names_uniprotkb": "Wsb2; Swip2", "gene_names_refseq": "Swip2; WSB-2; Wsb2", "protein_names_uniprotkb": "WD repeat and SOCS box-containing protein 2; SOCS box-containing WD protein SWiP-2; WSB-2", "protein_names_refseq": "SOCS box-containing WD protein SWiP-2; WD repeat and SOCS box-containing protein 2; WD-40-repeat-containing protein with a SOCS box 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:59043); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10354473;17001306;21750661;9419338", "class_list": "", "function": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB, UniProtKB]; Wsb-2 binding to the G-CSF-R reduced its cell surface expression and inhibited proliferation signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTI7;Q9R1M8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000209 protein polyubiquitination;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6EJB6-1", "uniprot_id": "UT14B_MOUSE", "mass": 85928.0, "length": 756, "protein_name": "U3 small nucleolar RNA-associated protein 14 homolog B", "gene_name": "Utp14b", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein 14 homolog B", "refseq_ac": "NP_001001981", "gene_names_uniprotkb": "Utp14b; Jsd", "gene_names_refseq": "4932411L21Rik; Utp14b; jsd", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 14 homolog B; Juvenile spermatogonial depletion protein", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 14 homolog B; UTP14, U3 small nucleolar ribonucleoprotein, homolog B; juvenile spermatogonial depletion protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:195434); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15258580;15289605;17291484;18356279;21183079;21750661;25428506;30084848;34428180", "class_list": "", "function": "Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis., [UniProtKB, PubMed, PubMed]; In adult male mice homozygous for the juvenile spermatogonial depletion (Utp14b jsd) mutation in the Utp14b gene, type A spermatogonia proliferate but undergo apoptosis before differentiation., [RefSeq, PubMed]; The novel cell-type-specific promoter for Utp14b likely evolved later, as the protein may have acquired a germ cell-specific function in spermatid development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6EJB5;Q8BL60", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032040 small-subunit processome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006364 rRNA processing;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6EJB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XG71-1", "uniprot_id": "UTP20_MOUSE", "mass": 317744.0, "length": 2788, "protein_name": "Small subunit processome component 20 homolog", "gene_name": "Utp20", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Utp20; Drim", "gene_names_refseq": "", "protein_names_uniprotkb": "Small subunit processome component 20 homolog; Down-regulated in metastasis protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:70683); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;25428506;25605945;30084848;30779550;31219806;31599954;34418053;34428180;35820727", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80V22;Q8BXH9;Q8CHL6;Q99K11", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5XG71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98156-1", "uniprot_id": "VLDLR_MOUSE", "mass": 96373.0, "length": 873, "protein_name": "Very low-density lipoprotein receptor", "gene_name": "Vldlr", "organism": "Mouse", "refseq_name": "very low-density lipoprotein receptor isoform b precursor", "refseq_ac": "NP_001154892", "gene_names_uniprotkb": "Vldlr", "gene_names_refseq": "Vldlr", "protein_names_uniprotkb": "Very low-density lipoprotein receptor; VLDL receptor; VLDL-R", "protein_names_refseq": "VLDL receptor; VLDL-R; very low-density lipoprotein receptor isoform b precursor", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1 (Disease Ontology:DOID:0070556); age related macular degeneration 1 (Disease Ontology:DOID:0110014); Alzheimer's disease (Disease Ontology:DOID:10652); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); autistic disorder (Disease Ontology:DOID:12849); dementia (Disease Ontology:DOID:1307); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (mmu:22359); (R-MMU-8866376); (R-MMU-8866427); (R-MMU-8964046)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10571241;11108739;12169628;12746448;17913789;20427281;21750661;23506116;24293365;7919660;7925422;8013374", "class_list": "", "function": "Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism (PubMed:11108739, PubMed:24293365). Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers (By similarity). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons (PubMed:23506116). Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (PubMed:17913789)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64022", "ec_number_list": "", "go_molecular_function": "GO:0034185 apolipoprotein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0001618 virus receptor activity;GO:0030229 very-low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0009986 cell surface", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0045860 positive regulation of protein kinase activity;GO:0071456 cellular response to hypoxia;GO:0034436 glycoprotein transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P98156-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP01-1", "uniprot_id": "VMAC_MOUSE", "mass": 19017.0, "length": 174, "protein_name": "Vimentin-type intermediate filament-associated coiled-coil protein", "gene_name": "Vmac", "organism": "Mouse", "refseq_name": "vimentin-type intermediate filament-associated coiled-coil protein isoform 1", "refseq_ac": "NP_849257", "gene_names_uniprotkb": "Vmac", "gene_names_refseq": "Vmac", "protein_names_uniprotkb": "Vimentin-type intermediate filament-associated coiled-coil protein", "protein_names_refseq": "vimentin-type intermediate filament-associated coiled-coil protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:106639)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKV2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045098 type III intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BP01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTT4-1", "uniprot_id": "VATG2_MOUSE", "mass": 13651.0, "length": 118, "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "Atp6v1g2", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit G 2 isoform 2", "refseq_ac": "NP_001334280", "gene_names_uniprotkb": "Atp6v1g2; Atp6g2; Ng38", "gene_names_refseq": "1500002D01Rik; Atp6g2; Atp6v1g2; NG38; VAG2", "protein_names_uniprotkb": "V-type proton ATPase subunit G 2; V-ATPase 13 kDa subunit 2; V-ATPase subunit G 2; Vacuolar proton pump subunit G 2", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit G; ATPase, H+ transporting, lysosomal (vacuolar proton pump); ATPase, H+ transporting, lysosomal 13kD, V1 subunit G; V-ATPase 13 kDa subunit 2; V-ATPase subunit G 2; V-type proton ATPase subunit G 2 isoform 2; V-type proton ATPase subunit G 2; lysosomal 13kDa; vacuolar proton pump subunit G 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66237); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12133826;14656967;21750661;30084848", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; V-ATPase G1 and G2 isoforms are expressed in mouse embryo neurons and are involved in synaptic vesicle acidification, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0042470 melanosome;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WTT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUA1-1", "uniprot_id": "WIF1_MOUSE", "mass": 41590.0, "length": 379, "protein_name": "Wnt inhibitory factor 1", "gene_name": "Wif1", "organism": "Mouse", "refseq_name": "wnt inhibitory factor 1 precursor", "refseq_ac": "NP_036045", "gene_names_uniprotkb": "Wif1", "gene_names_refseq": "WIF-1; Wif1", "protein_names_uniprotkb": "Wnt inhibitory factor 1; WIF-1", "protein_names_refseq": "wnt inhibitory factor 1 precursor", "tax_id": 10090, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); invasive ductal carcinoma (Disease Ontology:DOID:3008); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:24117)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10201374;15555925;21750661;28011936", "class_list": "", "function": "Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation., [UniProtKB, UniProtKB, UniProtKB]; WIF-1 protein inhibits rod production, and anti-WIF-1 antibodies increase rod production; in contrast, Wnt4 promotes rod production., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88721-1", "uniprot_id": "V2R_MOUSE", "mass": 40645.0, "length": 371, "protein_name": "Vasopressin V2 receptor", "gene_name": "Avpr2", "organism": "Mouse", "refseq_name": "vasopressin V2 receptor isoform a", "refseq_ac": "NP_062277", "gene_names_uniprotkb": "Avpr2; V2r", "gene_names_refseq": "ADHR; Avpr2; DI1; DIR; ND1; V2R; VPV2R", "protein_names_uniprotkb": "Vasopressin V2 receptor; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor; V2R", "protein_names_refseq": "antidiuretic hormone receptor; nephrogenic diabetes insipidus; renal-type arginine vasopressin receptor; vasopressin V2 receptor isoform a; vasopressin V2 receptor", "tax_id": 10090, "disease": "X-linked nephrogenic diabetes insipidus (Disease Ontology:DOID:0081060); nephrogenic syndrome of inappropriate antidiuresis (Disease Ontology:DOID:0112121); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (mmu:12000); (R-MMU-388479); (R-MMU-418555); (R-MMU-432040); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "30944256;32035616;33052234;35886951;36675199", "class_list": "", "function": "G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB]; Genome-Engineered mpkCCDc14 Cells as a New Resource for Studying AQP2. Publication Status: Online-Only, [RefSeq, PubMed]; Site-1 protease-derived (S1P-derived) soluble (pro)renin receptor (sPRR) participates in regulation of fluid homeostasis via targeting V2R. PF-429242 (S1P inhibitor) treatment or renal tubule-specific deletion of S1P impaired mice urine concentrating capability, which was rescued by sPRR-His. S1P-derived sPRR exerts a key role in determining renal V2R expression and, thus, urine concentrating capability. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the G-protein coupled receptor 1 family and the vasopressin/oxytocin receptor subfamily. The encoded protein is an arginine vasopressin receptor which, when stimulated, activates the Gs protein/adenylyl cyclase signaling cascade and is involved in water and electrolyte homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]; Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes mellitus via a vasopressin receptor 2-dependent pathway., [RefSeq, PubMed]; Vasopressin Receptor Type-2 Mediated Signaling in Renal Cell Carcinoma Stimulates Stromal Fibroblast Activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88721-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22561-1", "uniprot_id": "WT1_MOUSE", "mass": 49246.0, "length": 449, "protein_name": "Wilms tumor protein homolog", "gene_name": "Wt1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Wt1; Wt-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Wilms tumor protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "Frasier syndrome (Disease Ontology:DOID:0050438); ovarian serous carcinoma (Disease Ontology:DOID:0050933); nephrotic syndrome type 4 (Disease Ontology:DOID:0080383); Alzheimer's disease (Disease Ontology:DOID:10652); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); malignant mesothelioma (Disease Ontology:DOID:1790); nephroblastoma (Disease Ontology:DOID:2154); Denys-Drash syndrome (Disease Ontology:DOID:3764); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); renal Wilms' tumor (Disease Ontology:DOID:5176); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:22431)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14681305;14736876;16467207;1671709;16920711;16924231;17167543;17537799;19457926;21750661;35820727;8621495;9784496", "class_list": "", "function": "Transcription factor that plays an important role in cellular development and cell survival (PubMed:16467207, PubMed:16920711, PubMed:17537799). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Regulates the expression of numerous target genes, including EPO (PubMed:16467207). Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:17167543). Isoform 1 has lower affinity for DNA, and can bind RNA., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A402", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0003156 regulation of animal organ formation;GO:0007530 sex determination;GO:0035802 adrenal cortex formation;GO:2000020 positive regulation of male gonad development;GO:0072302 negative regulation of metanephric glomerular mesangial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P22561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29533-1", "uniprot_id": "VCAM1_MOUSE", "mass": 81317.0, "length": 739, "protein_name": "Vascular cell adhesion protein 1", "gene_name": "Vcam1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vcam1; Vcam-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Vascular cell adhesion protein 1; V-CAM 1; VCAM-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); lupus nephritis (Disease Ontology:DOID:0080162); aortic atherosclerosis (Disease Ontology:DOID:10230); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); thromboangiitis obliterans (Disease Ontology:DOID:12918); carotid stenosis (Disease Ontology:DOID:13001); interstitial cystitis (Disease Ontology:DOID:13949); pancreatic cancer (Disease Ontology:DOID:1793); essential thrombocythemia (Disease Ontology:DOID:2224); anemia (Disease Ontology:DOID:2355); glomerulonephritis (Disease Ontology:DOID:2921); carotid artery disease (Disease Ontology:DOID:3407); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); aortic disease (Disease Ontology:DOID:520); pulmonary hypertension (Disease Ontology:DOID:6432); gastrointestinal system disease (Disease Ontology:DOID:77); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); rheumatic myocarditis (Disease Ontology:DOID:8481); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-MMU-198933); (R-MMU-216083)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;1371918;1713592;19656770;21750661;28011936;30084848;30899004;31599954;32152506;33725478;34428180;35984892;37828378;7507076;7514674;7523515;7682556;7683304;7687058", "class_list": "glycogene", "function": "Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 8796, "biomarker_type": "", "glycan_count": 10, "disease_count": 28, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0050839 cell adhesion molecule binding;GO:0008131 primary methylamine oxidase activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0060384 innervation;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0007507 heart development;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P29533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29788-1", "uniprot_id": "VTNC_MOUSE", "mass": 54849.0, "length": 478, "protein_name": "Vitronectin", "gene_name": "Vtn", "organism": "Mouse", "refseq_name": "vitronectin precursor", "refseq_ac": "NP_035837", "gene_names_uniprotkb": "Vtn", "gene_names_refseq": "Vn; Vtn", "protein_names_uniprotkb": "Vitronectin; S-protein; Serum-spreading factor; VN", "protein_names_refseq": "S-protein; serum-spreading factor; vitronectin precursor", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Churg-Strauss syndrome (Disease Ontology:DOID:3049); coronary artery disease (Disease Ontology:DOID:3393); proteinuria (Disease Ontology:DOID:576); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:22370); (R-MMU-2129379); (R-MMU-216083); (R-MMU-3000170); (R-MMU-3000178); (R-MMU-977606)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;1372829;1719529;17330941;21183079;26495903;30084848;34428180;37453647;38773982;40997131;7505250;9733784", "class_list": "", "function": "Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5SYG4;Q8VII4;Q91X32;Q9D080", "ec_number_list": "", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0005044 scavenger receptor activity;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0061302 smooth muscle cell-matrix adhesion;GO:0006955 immune response;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P29788-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35969-1", "uniprot_id": "VGFR1_MOUSE", "mass": 149846.0, "length": 1333, "protein_name": "Vascular endothelial growth factor receptor 1", "gene_name": "Flt1", "organism": "Mouse", "refseq_name": "vascular endothelial growth factor receptor 1 isoform 1 precursor", "refseq_ac": "NP_034358", "gene_names_uniprotkb": "Flt1; Emrk2; Flt; Vegfr1", "gene_names_refseq": "Flt-1; Flt1; VEGFR-1; VEGFR1; sFlt1", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 1; 2.7.10.1; Embryonic receptor kinase 2; FLT-1; Fms-like tyrosine kinase 1; Tyrosine-protein kinase receptor FLT; VEGFR-1", "protein_names_refseq": "embryonic receptor kinase 2; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1 isoform 1 precursor; vascular endothelial growth factor receptor 1; vascular permeability factor receptor", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); cerebral cavernous malformation (Disease Ontology:DOID:0060669); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); pre-eclampsia (Disease Ontology:DOID:10591); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); corneal neovascularization (Disease Ontology:DOID:11382); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); retinopathy of prematurity (Disease Ontology:DOID:13025); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); Kawasaki disease (Disease Ontology:DOID:13378); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); Leydig cell tumor (Disease Ontology:DOID:2696); allergic contact dermatitis (Disease Ontology:DOID:3042); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); thyroid gland carcinoma (Disease Ontology:DOID:3963); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); osteoarthritis (Disease Ontology:DOID:8398); prostate carcinoma in situ (Disease Ontology:DOID:8634); vascular dementia (Disease Ontology:DOID:8725); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:14254); (R-MMU-194306); (R-MMU-195399)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11221852;14982871;18583712;20924106;21441409;26058077;29187734;30936473;34428180;7596436;8134130;8393164;9299537;9524283;9689083", "class_list": "glycogene", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (PubMed:30936473). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 33, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0A4;O55094;Q61517", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:1990384 hyaloid vascular plexus regression;GO:0001525 angiogenesis;GO:0006468 protein phosphorylation;GO:0006940 regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P35969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48614-1", "uniprot_id": "WN10B_MOUSE", "mass": 43119.0, "length": 389, "protein_name": "Protein Wnt-10b", "gene_name": "Wnt10b", "organism": "Mouse", "refseq_name": "protein Wnt-10b precursor", "refseq_ac": "NP_035848", "gene_names_uniprotkb": "Wnt10b; Wnt-10b; Wnt10; Wnt12", "gene_names_refseq": "Wnt10b; Wnt12", "protein_names_uniprotkb": "Protein Wnt-10b; Protein Wnt-12", "protein_names_refseq": "protein Wnt-10b precursor; protein Wnt-10b; wingless related MMTV integration site 10b; wnt-12", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); split hand-foot malformation 6 (Disease Ontology:DOID:0090026); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22410); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21447090;21750661;30016717;37691290;38302806;7892260;8682303;8875992", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin., [UniProtKB, PubMed]; Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice., [RefSeq, PubMed]; Wnt10b knockdown regulates the relative balance of adipose tissue-resident T cells and inhibits white fat deposition. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P70702", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0030858 positive regulation of epithelial cell differentiation;GO:0014835 myoblast differentiation involved in skeletal muscle regeneration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P48614-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57746-1", "uniprot_id": "VATD_MOUSE", "mass": 28369.0, "length": 247, "protein_name": "V-type proton ATPase subunit D", "gene_name": "Atp6v1d", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit D", "refseq_ac": "NP_076210", "gene_names_uniprotkb": "Atp6v1d; Atp6m; Vatd", "gene_names_refseq": "1110004P10Rik; Atp6m; Atp6v1d; VATD; Vma8", "protein_names_uniprotkb": "V-type proton ATPase subunit D; V-ATPase 28 kDa accessory protein; V-ATPase subunit D; Vacuolar proton pump subunit D", "protein_names_refseq": "ATPase, H+ transporting lysosomal (vacuolar proton pump); ATPase, H+ transporting, V1 subunit D; ATPase, H+ transporting, lysosomal 34kD, V1 subunit D; V-ATPase 28 kDa accessory protein; V-ATPase subunit D; V-type proton ATPase subunit D; lysosomal 34kDa; vacuolar proton pump subunit D", "tax_id": 10090, "disease": "", "pathway": " (mmu:73834); (R-MMU-1222556); (R-MMU-6798695); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "11435709;35820727", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005654 nucleoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0060271 cilium assembly;GO:0061512 protein localization to cilium;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification;GO:0038020 insulin receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P57746-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62814-1", "uniprot_id": "VATB2_MOUSE", "mass": 56551.0, "length": 511, "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "Atp6v1b2", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit B, brain isoform", "refseq_ac": "NP_031535", "gene_names_uniprotkb": "Atp6v1b2; Atp6b2; Vat2", "gene_names_refseq": "Atp6b2; Atp6v1b2; HO57", "protein_names_uniprotkb": "V-type proton ATPase subunit B, brain isoform; Endomembrane proton pump 58 kDa subunit; V-ATPase subunit B 2; Vacuolar proton pump subunit B 2", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit B; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa; ATPase, H+ transporting, lysosomal 56/58kD, V1 subunit B; V-ATPase subunit B 2; V-type proton ATPase subunit B, brain isoform; endomembrane proton pump 58 kDa subunit; lysosomal 56/58kDa; vacuolar proton pump subunit B 2", "tax_id": 10090, "disease": "follicular lymphoma (Disease Ontology:DOID:0050873); autosomal dominant congenital deafness with onychodystrophy (Disease Ontology:DOID:0080720); renal tubular acidosis (Disease Ontology:DOID:14219); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:11966); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10671200;15013950;16174750;17898041;22645316;24913193;25428506;29187734;29993276;30084848;30779550;33300544;34203471;35820727;37628590;39627609;8741845", "class_list": "", "function": "Expressed in most, if not all, proton-secreting cells in the epithelium lining the nephron and the collecting ducts, and it is also present in proton-secreting clear cells of the epididymis, [RefSeq, PubMed]; Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:17898041). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (PubMed:17898041)., [UniProtKB, PubMed, UniProtKB]; The ATP6V1B2 DDOD/DOORS-Associated p.Arg506* Variant Causes Hyperactivity and Seizures in Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09045;P50517;Q3TG74;Q3TL62;Q3TVK6;Q3TWR0;Q3U791;Q3U7C8;Q3U9Z0;Q3UAW7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P62814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63024-1", "uniprot_id": "VAMP3_MOUSE", "mass": 11480.0, "length": 103, "protein_name": "Vesicle-associated membrane protein 3", "gene_name": "Vamp3", "organism": "Mouse", "refseq_name": "vesicle-associated membrane protein 3", "refseq_ac": "NP_033524", "gene_names_uniprotkb": "Vamp3; Syb3", "gene_names_refseq": "D130027G05Rik; VAMP-3; Vamp3; ceb", "protein_names_uniprotkb": "Vesicle-associated membrane protein 3; CEB; Cellubrevin; Synaptobrevin-3; VAMP-3", "protein_names_refseq": "cellubrevin; synaptobrevin-3; vesicle-associated membrane protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22319); (R-MMU-1236974); (R-MMU-6811440); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 15, "publication_count": 8, "publication_id_list": "11238894;20057356;28770820;31219806;34707216;37603540;37965323;9396746", "class_list": "", "function": "Endocytic BDNF secretion regulated by Vamp3 in astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production. Publication Status: Online-Only, [RefSeq, PubMed]; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network., [UniProtKB, UniProtKB]; The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH70;Q64271", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0034446 substrate adhesion-dependent cell spreading;GO:0016192 vesicle-mediated transport;GO:0001921 positive regulation of receptor recycling;GO:0043001 Golgi to plasma membrane protein transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P63024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83853-1", "uniprot_id": "VAM6L_MOUSE", "mass": 1075.0, "length": 8, "protein_name": "Vam6-like protein", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Vam6-like protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15110766", "class_list": "", "function": "May play a role in clustering and fusion of late endosomes and lysosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83853-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97953-1", "uniprot_id": "VEGFC_MOUSE", "mass": 46471.0, "length": 415, "protein_name": "Vascular endothelial growth factor C", "gene_name": "Vegfc", "organism": "Mouse", "refseq_name": "vascular endothelial growth factor C precursor", "refseq_ac": "NP_033532", "gene_names_uniprotkb": "Vegfc", "gene_names_refseq": "VEGF-C; Vegfc", "protein_names_uniprotkb": "Vascular endothelial growth factor C; Flt4 ligand; Flt4-L; VEGF-C; VRP; Vascular endothelial growth factor-related protein", "protein_names_refseq": "VRP; flt4 ligand; flt4-L; vascular endothelial growth factor C precursor; vascular endothelial growth factor-related protein", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); hereditary lymphedema (Disease Ontology:DOID:0050580); hereditary lymphedema ID (Disease Ontology:DOID:0070209); urinary bladder cancer (Disease Ontology:DOID:11054); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); papillary carcinoma (Disease Ontology:DOID:3113); breast carcinoma (Disease Ontology:DOID:3459); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:22341); (R-MMU-114608); (R-MMU-194313); (R-MMU-195399)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;20415667;34428180;9012504;9247316", "class_list": "", "function": "Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "C6F5S8;C6F5S9;C6F5T0;Q543R6", "ec_number_list": "", "go_molecular_function": "GO:0043185 vascular endothelial growth factor receptor 3 binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0036454 growth factor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06318-1", "uniprot_id": "UTER_MOUSE", "mass": 10519.0, "length": 96, "protein_name": "Uteroglobin", "gene_name": "Scgb1a1", "organism": "Mouse", "refseq_name": "uteroglobin precursor", "refseq_ac": "NP_035811", "gene_names_uniprotkb": "Scgb1a1; Cc10; Ugb; Utg", "gene_names_refseq": "CC10; CC16; CCSP; PCB-BP; Scgb1a1; UGB; UG; Utg", "protein_names_uniprotkb": "Uteroglobin; CC10; CCPBP; Club cell 17 kDa protein; Club cell phospholipid-binding protein; Club cells 10 kDa secretory protein; PCB-binding protein; Secretoglobin family 1A member 1", "protein_names_refseq": "Blastokinin; CCPBP; PCB-binding protein; club cell 17 kDa protein; club cell phospholipid-binding protein; club cell secretory protein; club cells 10 kDa secretory protein; uteroglobin precursor; uteroglobin", "tax_id": 10090, "disease": "otitis media (Disease Ontology:DOID:10754); meconium aspiration syndrome (Disease Ontology:DOID:11049); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (mmu:22287)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "7916613;8020953;8398159;8440203", "class_list": "", "function": "Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019834 phospholipase A2 inhibitor activity;GO:0097160 polychlorinated biphenyl binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0030141 secretory granule", "go_biological_process": "GO:0034021 response to silicon dioxide;GO:0032714 negative regulation of interleukin-5 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q06318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2NKI2-1", "uniprot_id": "VAX1_MOUSE", "mass": 35167.0, "length": 338, "protein_name": "Ventral anterior homeobox 1", "gene_name": "Vax1", "organism": "Mouse", "refseq_name": "ventral anterior homeobox 1", "refseq_ac": "NP_033527", "gene_names_uniprotkb": "Vax1", "gene_names_refseq": "Vax1", "protein_names_uniprotkb": "Ventral anterior homeobox 1", "protein_names_refseq": "ventral anterior homeobox 1; ventral anterior homeobox containing gene 1", "tax_id": 10090, "disease": "syndromic microphthalmia 11 (Disease Ontology:DOID:0111804)", "pathway": " (mmu:22326)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10421837;10601035;21856776;36737666;38205198;9636075", "class_list": "", "function": "The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the EMX homeobox protein family. The encoded protein functions as a transcription factor which is important in the development of anterior ventral forebrain and visual system. Disruption of this gene causes impairment in the developing forebrain, where the encoded protein is necessary for axon guidance and major tract formation. [provided by RefSeq, Dec 2015]., [RefSeq]; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88880", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2NKI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2QI47-1", "uniprot_id": "USH2A_MOUSE", "mass": 569660.0, "length": 5193, "protein_name": "Usherin", "gene_name": "Ush2A; Ush2a", "organism": "Mouse", "refseq_name": "usherin precursor", "refseq_ac": "NP_067383", "gene_names_uniprotkb": "Ush2A; Ush2a; Gm676", "gene_names_refseq": "A930011D15Rik; A930037M10Rik; Gm676; Gm983; Mush2a; Ush2a; Ushrn", "protein_names_uniprotkb": "Usherin; Usher syndrome type IIa protein homolog; Usher syndrome type-2A protein homolog", "protein_names_refseq": "Usher syndrome 2A (autosomal recessive, mild) homolog; usher syndrome type IIa protein homolog; usher syndrome type-2A protein homolog; usherin precursor", "tax_id": 10090, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); nonsyndromic deafness (Disease Ontology:DOID:0050563); retinitis pigmentosa 39 (Disease Ontology:DOID:0110360); Usher syndrome type 2 (Disease Ontology:DOID:0110827); Usher syndrome type 2A (Disease Ontology:DOID:0110838); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:22283)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11788194;12160733;12433396;16301216;16301217;17567809;20502675;21750661;22872234;23055499;24334608;25406310;25428506;30084848;31219806;33498833;36810733;37066759;37700068", "class_list": "", "function": "Conservation of usherin is seen at the nucleotide and amino acid level when comparing the mouse and human gene sequences., [RefSeq, PubMed]; Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment., [RefSeq, PubMed]; Expressed in the cells of the outer nuclear layer of the retina and in cochlea., [RefSeq, PubMed]; Expression of the human usherin c.2299delG mutation leads to early-onset auditory loss and stereocilia disorganization. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in hearing and vision as member of the USH2 complex (PubMed:20502675). In the inner ear, required for the maintenance of hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells (PubMed:20502675, PubMed:24334608). In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport (PubMed:20502675)., [UniProtKB, PubMed, PubMed]; Peripheral Anomalies in USH2A Cause Central Auditory Anomalies in a Mouse Model of Usher Syndrome and CAPD. Publication Status: Online-Only, [RefSeq, PubMed]; The usherin mutation c.2299delG leads to its mislocalization and disrupts interactions with whirlin and VLGR1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 69, "predicted_n_glycosites": 64, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 73, "binding_glycan_count": 0, "secondary_ac_list": "E9QLJ9;Q9JLP3", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0005604 basement membrane;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0048496 maintenance of animal organ identity;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0009887 animal organ morphogenesis;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q2QI47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1V6-1", "uniprot_id": "UEVLD_MOUSE", "mass": 51681.0, "length": 471, "protein_name": "Ubiquitin-conjugating enzyme E2 variant 3", "gene_name": "Uevld", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 variant 3", "refseq_ac": "NP_001035785", "gene_names_uniprotkb": "Uevld; Attp; Uev3", "gene_names_refseq": "8430408E05Rik; Attp; Uevld", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 variant 3; EV and lactate/malate dehydrogenase domain-containing protein; UEV-3", "protein_names_refseq": "EV and lactate/malate dehydrogenase domain-containing protein; UEV-3; signaling molecule ATTP; ubiquitin-conjugating enzyme E2 variant 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:54122)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Possible negative regulator of polyubiquitination., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08761;Q7TQD3", "ec_number_list": "", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0015031 protein transport;GO:0006355 regulation of DNA-templated transcription;GO:0008333 endosome to lysosome transport;GO:0019752 carboxylic acid metabolic process;GO:0044283 small molecule biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U1V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ZK22-1", "uniprot_id": "VEZA_MOUSE", "mass": 87987.0, "length": 780, "protein_name": "Vezatin", "gene_name": "Vezt", "organism": "Mouse", "refseq_name": "vezatin isoform 2", "refseq_ac": "NP_001291501", "gene_names_uniprotkb": "Vezt", "gene_names_refseq": "A630071D13Rik; Vezt", "protein_names_uniprotkb": "Vezatin", "protein_names_refseq": "vezatin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:215008)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16199027;17114649;17379651;17452094;17567809;21750661;25428506;34642320;35820727", "class_list": "", "function": "Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process., [UniProtKB, PubMed, PubMed]; Required for morphogenesis of the preimplantation mouse embryo., [RefSeq, PubMed]; These in vitro observations reinforce the idea that homozygous vezatin-null mutants die at the time of implantation because of a defect in intercellular adhesion., [RefSeq, PubMed]; This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]; Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0M8X3;Q3ZK21;Q8BY12;Q8BYB4;Q8BZB5", "ec_number_list": "", "go_molecular_function": "GO:0017022 myosin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0043009 chordate embryonic development;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3ZK22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q505H4-1", "uniprot_id": "VWC2L_MOUSE", "mass": 24528.0, "length": 222, "protein_name": "von Willebrand factor C domain-containing protein 2-like", "gene_name": "Vwc2l", "organism": "Mouse", "refseq_name": "von Willebrand factor C domain-containing protein 2-like isoform 2 precursor", "refseq_ac": "NP_001297587", "gene_names_uniprotkb": "Vwc2l", "gene_names_refseq": "A830006F12Rik; Brl; Vwc2l", "protein_names_uniprotkb": "von Willebrand factor C domain-containing protein 2-like; Brorin-like", "protein_names_refseq": "Brorin-like; von Willebrand factor C domain-containing protein 2-like isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:320460)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19852960;22209847;22632720", "class_list": "", "function": "May play a role in neurogenesis. May promote matrix mineralization (PubMed:22209847), but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line (PubMed:19852960)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7X8X0;E0CXU0;E6Y2G9;Q8BNE9;Q8BNU5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q505H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DQQ6-1", "uniprot_id": "WFD13_MOUSE", "mass": 8798.0, "length": 81, "protein_name": "WAP four-disulfide core domain protein 13", "gene_name": "Wfdc13", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 13 precursor", "refseq_ac": "NP_001012722", "gene_names_uniprotkb": "Wfdc13; Wfdc13l1", "gene_names_refseq": "Wfdc13l1; Wfdc13", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 13; WAP four-disulfide core domain 13-like 1", "protein_names_refseq": "WAP four-disulfide core domain 13-like 1; WAP four-disulfide core domain protein 13 precursor; WAP four-disulfide core domain protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:408190)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060002;15950183", "class_list": "", "function": "Putative acid-stable proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IE33", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5DQQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5KU39-1", "uniprot_id": "VPS41_MOUSE", "mass": 98602.0, "length": 853, "protein_name": "Vacuolar protein sorting-associated protein 41 homolog", "gene_name": "Vps41", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 41 homolog", "refseq_ac": "NP_742118", "gene_names_uniprotkb": "Vps41", "gene_names_refseq": "Vam2; Vps41; mVam2", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 41 homolog; VAM2 homolog; mVAM2", "protein_names_refseq": "VAM2 homolog; vacuolar protein sorting 41; vacuolar protein sorting-associated protein 41 homolog", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 29 (Disease Ontology:DOID:0070410); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:218035)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23245320;25605945;31219806;33168621;34428180;37562348", "class_list": "", "function": "Lack of Coxiella burnetii targeting to degradative compartments involves an antagonistic engagement of TLR4 by lipopolysaccharides, lack of p38alpha-MAPK-driven phosphorylation, and block in recruitment of the Vps41 to lipopolysaccharide-containing vesicles., [RefSeq, PubMed]; Pancreatic beta-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion., [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (By similarity). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (By similarity). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05AE9;Q3TPS1;Q80V99;Q8BKK6;Q8CG01;Q8CJC3", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol", "go_biological_process": "GO:0007034 vacuolar transport;GO:0045055 regulated exocytosis;GO:0016236 macroautophagy;GO:0008333 endosome to lysosome transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5KU39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60931-1", "uniprot_id": "VDAC3_MOUSE", "mass": 30753.0, "length": 283, "protein_name": "Non-selective voltage-gated ion channel VDAC3", "gene_name": "Vdac3", "organism": "Mouse", "refseq_name": "non-selective voltage-gated ion channel VDAC3 isoform 2", "refseq_ac": "NP_035826", "gene_names_uniprotkb": "Vdac3", "gene_names_refseq": "Vdac3", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC3; Outer mitochondrial membrane protein porin 3; VDAC-3; mVDAC3", "protein_names_refseq": "VDAC-3; channel protein VDAC3; mVDAC3; mitochondrial outer membrane protein; non-selective voltage-gated ion channel VDAC3 isoform 2; non-selective voltage-gated ion channel VDAC3; outer mitochondrial membrane protein porin 3; voltage-dependent anion-selective channel protein 3", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:22335); (R-MMU-5205685); (R-MMU-5689880)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;22645316;23576753;23806337;24788674;28935714;29180450;31219806;33300544;34428180;35228556;36210013;37453647;39927985;8812436", "class_list": "", "function": "Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (PubMed:35228556)., [UniProtKB, UniProtKB, PubMed]; Results suggest that knocking out mitochondrial VDAC3 increases ROS, alters renal sodium transport, and leads to hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNG2", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0015288 porin activity;GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007612 learning;GO:0007268 chemical synaptic transmission;GO:0001662 behavioral fear response;GO:0007270 neuron-neuron synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q60931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60992-1", "uniprot_id": "VAV2_MOUSE", "mass": 99915.0, "length": 868, "protein_name": "Guanine nucleotide exchange factor VAV2", "gene_name": "Vav2", "organism": "Mouse", "refseq_name": "guanine nucleotide exchange factor VAV2", "refseq_ac": "NP_033526", "gene_names_uniprotkb": "Vav2", "gene_names_refseq": "2810040F13Rik; Vav-2; Vav2", "protein_names_uniprotkb": "Guanine nucleotide exchange factor VAV2; VAV-2", "protein_names_refseq": "guanine nucleotide exchange factor VAV2; vav 2 oncogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:22325); (R-MMU-114604); (R-MMU-193648); (R-MMU-2029482); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-3928665); (R-MMU-416482); (R-MMU-4420097); (R-MMU-445144); (R-MMU-5218920); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9748787); (R-MMU-9958810)", "pathway_count": 22, "publication_count": 6, "publication_id_list": "16782872;17202406;22027834;23699534;35534539;8710375", "class_list": "", "function": "Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly., [UniProtKB, PubMed]; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function., [RefSeq, PubMed]; These results indicate that Vav2 plays crucial roles in the maintenance of cardiovascular homeostasis in mice., [RefSeq, PubMed]; This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AH49", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0016477 cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q60992-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q640M1-1", "uniprot_id": "UT14A_MOUSE", "mass": 87265.0, "length": 767, "protein_name": "U3 small nucleolar RNA-associated protein 14 homolog A", "gene_name": "Utp14a", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein 14 homolog A", "refseq_ac": "NP_082552", "gene_names_uniprotkb": "Utp14a; JsdX; Kiaa0266", "gene_names_refseq": "2700066J21Rik; JsdX; NY-CO-16; SDCCAG16; Utp14a; mKIAA0266", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 14 homolog A; Jsd-like X-linked protein; Juvenile spermatogonial depletion-like X-linked protein", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 14 homolog A; UTP14, U3 small nucleolar ribonucleoprotein, homolog A; jsd-like X-linked protein; juvenile spermatogonial depletion-like X-linked protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72554); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15258580;15289605;21183079;24463520;25428506;29187734;30910870", "class_list": "", "function": "May be required for ribosome biogenesis., [UniProtKB]; The results shed light on the mechanism of DHX37 and the function of UTP14A in controlling its recruitment and activity during ribosome biogenesis. Erratum:[RNA. 2019 Nov;25(11):1576. doi: 10.1261/rna.072900.119. PMID: 31619564], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFX7;Q6A094;Q6EJB4;Q6P6L1;Q9CZK8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q640M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64267-1", "uniprot_id": "XPA_MOUSE", "mass": 31398.0, "length": 272, "protein_name": "DNA repair protein complementing XP-A cells homolog", "gene_name": "Xpa", "organism": "Mouse", "refseq_name": "DNA repair protein complementing XP-A cells homolog isoform 1", "refseq_ac": "NP_035858", "gene_names_uniprotkb": "Xpa; Xpac", "gene_names_refseq": "Xpac; Xpa", "protein_names_uniprotkb": "DNA repair protein complementing XP-A cells homolog; Xeroderma pigmentosum group A-complementing protein homolog", "protein_names_refseq": "DNA repair protein complementing XP-A cells homolog isoform 1; DNA repair protein complementing XP-A cells homolog; xeroderma pigmentosum group A-complementing protein homolog", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843)", "pathway": " (mmu:22590); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11764287;15345747;20304803;21750661;25428506;32142649;34428180;35820727;8127648", "class_list": "", "function": "Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALZ7;Q9CVA0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003684 damaged DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0010506 regulation of autophagy;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NV72-1", "uniprot_id": "WDCP_MOUSE", "mass": 72268.0, "length": 663, "protein_name": "WD repeat and coiled-coil-containing protein", "gene_name": "Wdcp", "organism": "Mouse", "refseq_name": "WD repeat and coiled-coil-containing protein isoform 1", "refseq_ac": "NP_001164329", "gene_names_uniprotkb": "Wdcp", "gene_names_refseq": "A430092C04; Wdcp", "protein_names_uniprotkb": "WD repeat and coiled-coil-containing protein", "protein_names_refseq": "WD repeat and coiled-coil-containing protein C2orf44 homolog; WD repeat and coiled-coil-containing protein isoform 1; WD repeat-containing protein C2orf44 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:238037)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2S5;Q8C9V8", "ec_number_list": "", "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "", "go_biological_process": "GO:0051259 protein complex oligomerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NV72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQL4-1", "uniprot_id": "WDR43_MOUSE", "mass": 75381.0, "length": 677, "protein_name": "WD repeat-containing protein 43", "gene_name": "Wdr43", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 43", "refseq_ac": "NP_783570", "gene_names_uniprotkb": "Wdr43; Kiaa0007", "gene_names_refseq": "2610318G08Rik; Wdr43; Wrd43; mKIAA0007", "protein_names_uniprotkb": "WD repeat-containing protein 43", "protein_names_refseq": "WD repeat-containing protein 43", "tax_id": 10090, "disease": "", "pathway": " (mmu:72515); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "21750661;25428506;25605945;30084848;30779550;31128943;31219806;32152506;34428180;34887587;36210013", "class_list": "", "function": "RNA targets ribogenesis Factor WDR43 to chromatin for transcription and pluripotency control., [RefSeq, PubMed]; Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (By similarity). Essential for stem cell pluripotency and embryonic development (PubMed:31128943). In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (PubMed:31128943)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U895", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0000993 RNA polymerase II complex binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0000785 chromatin;GO:0032040 small-subunit processome", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:2000036 regulation of stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6ZQL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70UZ7-1", "uniprot_id": "VWA2_MOUSE", "mass": 85639.0, "length": 791, "protein_name": "von Willebrand factor A domain-containing protein 2", "gene_name": "Vwa2", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 2 precursor", "refseq_ac": "NP_766428", "gene_names_uniprotkb": "Vwa2; Amaco", "gene_names_refseq": "Amaco; Vwa2", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 2; A domain-containing protein similar to matrilin and collagen; AMACO", "protein_names_refseq": "VWA-like domains, matrilins and collagens; a domain-containing protein similar to matrilin and collagen; von Willebrand factor A domain-containing protein 2 precursor; von Willebrand factor A domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:240675)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14506275;19651211;24232570;37047755;39927985", "class_list": "", "function": "AMACO is a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney, [RefSeq, PubMed]; Murine AMACO localizes subjacent to the basement membrane in kidney and skin. AMACO supports beta1 integrin-mediated adhesion of a keratinocyte-like cell line, HaCaT, and a fibroblast cell line, Wi26, in an RGD-dependent manner., [RefSeq, PubMed]; Our data suggest that AMACO represents a member of the Fraser complex., [RefSeq, PubMed]; The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can Form Anchoring Cords in the Absence of AMACO at the Dermal-Epidermal Junction of Mouse Skin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q14AY2;Q14BI0;Q3UM88", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005604 basement membrane", "go_biological_process": "GO:0007161 calcium-independent cell-matrix adhesion;GO:0046626 regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q70UZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQN3-1", "uniprot_id": "WFKN2_MOUSE", "mass": 63333.0, "length": 571, "protein_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2", "gene_name": "Wfikkn2", "organism": "Mouse", "refseq_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor", "refseq_ac": "NP_861540", "gene_names_uniprotkb": "Wfikkn2; Gasp1", "gene_names_refseq": "2610304F08Rik; Gasp1; WFIKKNRP; Wfikkn2", "protein_names_uniprotkb": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; GASP-1; Growth and differentiation factor-associated serum protein 1; mGASP-1", "protein_names_refseq": "GASP-1; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor; WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2; growth and differentiation factor-associated serum protein 1; mGASP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:278507)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12595574;20164830;30814254", "class_list": "", "function": "Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). Inhibits the biological activity of mature myostatin, but not activin., [UniProtKB]; Report of the identification of growth and differentiation factor-associated serum protein-1 (GASP-1) associated with endogenous myostatin in normal serum, [RefSeq, PubMed]; Results indicate that both WFIKKN and follistatin utilize their FSDs to block the type II receptor but do so via different binding interactions., [RefSeq, PubMed]; Taken together, this study provides evidence that GASP1 regulates CB1 receptor downregulation in vivo, and that postendocytic receptor trafficking has a key role in the development of tolerance to WIN55,212-2., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUS5", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0048019 receptor antagonist activity;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001501 skeletal system development;GO:0060021 roof of mouth development;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0055001 muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TQN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XH4-1", "uniprot_id": "WSCD1_MOUSE", "mass": 64981.0, "length": 572, "protein_name": "Sialate:O-sulfotransferase 1", "gene_name": "Wscd1", "organism": "Mouse", "refseq_name": "sialate:O-sulfotransferase 1", "refseq_ac": "NP_808286", "gene_names_uniprotkb": "Wscd1; Kiaa0523", "gene_names_refseq": "Wscd1; mKIAA0523", "protein_names_uniprotkb": "Sialate:O-sulfotransferase 1; WSC domain-containing protein 1", "protein_names_refseq": "WSC domain-containing protein 1; sialate:O-sulfotransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:216881)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848;35864127", "class_list": "", "function": "Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycolipids such as GM1 gangliosides., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ40;Q5DU24;Q8BX34", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80XH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XI7-1", "uniprot_id": "VOME_MOUSE", "mass": 62448.0, "length": 591, "protein_name": "Vomeromodulin", "gene_name": "Bpifb9a", "organism": "Mouse", "refseq_name": "vomeromodulin precursor", "refseq_ac": "NP_780376", "gene_names_uniprotkb": "Bpifb9a", "gene_names_refseq": "4833413D08Rik; AI413838; Bpifb9a", "protein_names_uniprotkb": "Vomeromodulin; BPI fold-containing family B member 9A", "protein_names_refseq": "vomeromodulin precursor; vomeromodulin", "tax_id": 10090, "disease": "", "pathway": " (mmu:71425)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;20368189;34203471", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AJD0;Q5XK13;Q8CDY1", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80XI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGW2-1", "uniprot_id": "WBP1L_MOUSE", "mass": 38347.0, "length": 348, "protein_name": "WW domain binding protein 1-like", "gene_name": "Wbp1l", "organism": "Mouse", "refseq_name": "WW domain binding protein 1-like isoform 1 precursor", "refseq_ac": "NP_001171283", "gene_names_uniprotkb": "Wbp1l; D19Wsu162e; Opal1", "gene_names_refseq": "D19Wsu162e; Opal1; Wbp1l", "protein_names_uniprotkb": "WW domain binding protein 1-like; Outcome predictor in acute leukemia 1 homolog", "protein_names_refseq": "WW domain binding protein 1-like isoform 1 precursor; outcome predictor in acute leukemia 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:226178)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26495903;30779550;31845480;32152506", "class_list": "", "function": "Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF48;Q3U3M2;Q6PD43;Q8R0W8", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030097 hemopoiesis;GO:0031398 positive regulation of protein ubiquitination;GO:0038160 CXCL12-activated CXCR4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMC1-1", "uniprot_id": "VATG3_MOUSE", "mass": 13749.0, "length": 118, "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "Atp6v1g3", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit G 3", "refseq_ac": "NP_796371", "gene_names_uniprotkb": "Atp6v1g3; Atp6g3", "gene_names_refseq": "Atp6v1g3", "protein_names_uniprotkb": "V-type proton ATPase subunit G 3; V-ATPase 13 kDa subunit 3; V-ATPase subunit G 3; Vacuolar proton pump subunit G 3", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit G; V-ATPase 13 kDa subunit 3; V-ATPase subunit G 3; V-type proton ATPase subunit G 3; vacuolar proton pump subunit G 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:338375); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "12527205", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030672 synaptic vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BMC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BN21-1", "uniprot_id": "VRK2_MOUSE", "mass": 58119.0, "length": 503, "protein_name": "Serine/threonine-protein kinase VRK2", "gene_name": "Vrk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase VRK2 isoform 2", "refseq_ac": "NP_001239376", "gene_names_uniprotkb": "Vrk2", "gene_names_refseq": "2810003O05Rik; Vrk2", "protein_names_uniprotkb": "Serine/threonine-protein kinase VRK2; 2.7.11.1; Vaccinia-related kinase 2", "protein_names_refseq": "serine/threonine-protein kinase VRK2 isoform 2; serine/threonine-protein kinase VRK2; vaccinia virus BIR kinase related kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69922); (R-MMU-2980766); (R-MMU-2995383); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "12417526;12782311;14645249;21750661;30084848;31142202;33785841;34428180;35173553;37452335", "class_list": "", "function": "Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249). Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (By similarity). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (By similarity). Phosphorylates histone H3 (By similarity). Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity (By similarity). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (By similarity). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (By similarity). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (By similarity). May also phosphorylate MAPK8IP1 (By similarity). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity)., [UniProtKB, UniProtKB, PubMed]; VRK genes play a role during embryonic development of hematopoiesis, [RefSeq, PubMed]; VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating IKKbeta in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U415;Q5F1Z5;Q5SP88;Q8BPU8;Q8CJ46;Q91WS1;Q9CZF9", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.6.5.2;2.7.11.39;2.3.1.-;1.3.1.70;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:2000659 regulation of interleukin-1-mediated signaling pathway;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0006974 DNA damage response;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BN21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTE6-1", "uniprot_id": "WFD21_MOUSE", "mass": 6792.0, "length": 63, "protein_name": "Protein Wfdc21", "gene_name": "Wfdc21", "organism": "Mouse", "refseq_name": "protein Wfdc21 precursor", "refseq_ac": "NP_899072", "gene_names_uniprotkb": "Wfdc21; Wdnml1", "gene_names_refseq": "1100001G20Rik; Wdnm1-like; Wfdc21", "protein_names_uniprotkb": "Protein Wfdc21; Wdnm1-like protein", "protein_names_refseq": "protein Wfdc21 precursor; protein Wfdc21", "tax_id": 10090, "disease": "", "pathway": " (mmu:66107)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16936091;18492766;29900929", "class_list": "", "function": "Authors found that Wfdc21 level was elevated in the CLP-induced animal model and LPS-treated RAW264.7 cells. Furthermore, the downregulation of Wfdc21 modulated the concentration of pro-inflammatory factors in LPS-treated macrophages, such as IL-1beta and TNF-alpha, in LPS-treated macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; May promote activation of the metalloproteinase MMP2., [UniProtKB, PubMed]; PMID:16936091 mostly concerns studies in rat, but shows similarity between rat and mouse WDNM1-like proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor;GO:0045087 innate immune response;GO:0050872 white fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BTE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C2E7-1", "uniprot_id": "WASC5_MOUSE", "mass": 134110.0, "length": 1159, "protein_name": "WASH complex subunit 5", "gene_name": "Washc5", "organism": "Mouse", "refseq_name": "WASH complex subunit 5", "refseq_ac": "NP_705776", "gene_names_uniprotkb": "Washc5; Kiaa0196", "gene_names_refseq": "E430025E21Rik; Washc5; strumpellin", "protein_names_uniprotkb": "WASH complex subunit 5; WASH complex subunit strumpellin", "protein_names_refseq": "WASH complex subunit 5; WASH complex subunit strumpellin", "tax_id": 10090, "disease": "Ritscher-Schinzel syndrome 1 (Disease Ontology:DOID:0060571); hereditary spastic paraplegia 8 (Disease Ontology:DOID:0110823)", "pathway": " (mmu:223593)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;24998208;30061306;31219806;34312900;34428180;36210013;37308549;37392480", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208)., [UniProtKB, PubMed, UniProtKB]; N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue., [RefSeq, PubMed]; Strumpellin/WASHC5 regulates the structural plasticity of cortical neurons involved in gait coordination., [RefSeq, PubMed]; The WASH-complex subunit Strumpellin regulates integrin alphaIIbbeta3 trafficking in murine platelets. Publication Status: Online-Only, [RefSeq, PubMed]; These results underscore a key role for the WASH complex and its core subunit, Str, in the endolysosomal system. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGY1;Q8K2J2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0051125 regulation of actin nucleation;GO:0010976 positive regulation of neuron projection development;GO:0015031 protein transport;GO:0006909 phagocytosis;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C2E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5G2-1", "uniprot_id": "VASH2_MOUSE", "mass": 40499.0, "length": 355, "protein_name": "Tubulinyl-Tyr carboxypeptidase 2", "gene_name": "Vash2", "organism": "Mouse", "refseq_name": "tubulinyl-Tyr carboxypeptidase 2", "refseq_ac": "NP_659128", "gene_names_uniprotkb": "Vash2; Vashl", "gene_names_refseq": "B130052G07Rik; Vash2", "protein_names_uniprotkb": "Tubulinyl-Tyr carboxypeptidase 2; 3.4.17.17; Vasohibin-2; Vasohibin-like protein", "protein_names_refseq": "tubulinyl-Tyr carboxypeptidase 2; vasohibin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:226841)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19204325;22872234;24885408;26794318;29146868;29641565;30084848;31235911;31324789;32604722", "class_list": "", "function": "Genetic Deletion of Vasohibin-2 Exacerbates Ischemia-Reperfusion-Induced Acute Kidney Injury. Publication Status: Online-Only, [RefSeq, PubMed]; High VASH2 expression is associated with diabetes-induced glomerular alterations, particularly impaired filtration barrier and mesangial expansion. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of vasohibin-2 is associated with deficient angiogenesis in the termination sprouting front of endothelial cells., [RefSeq, PubMed]; Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911)., [UniProtKB, PubMed, PubMed, PubMed]; VASH2 may modulate the onset of tumors in the gastrointestinal tract by regulating tumor angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TR02;Q8BRA1;Q8R1R8", "ec_number_list": "3.4.17.17", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0004181 metallocarboxypeptidase activity;GO:0106423 tubulin-tyrosine carboxypeptidase", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000768 syncytium formation by plasma membrane fusion;GO:0006508 proteolysis;GO:0045766 positive regulation of angiogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0045765 regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C5G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C754-1", "uniprot_id": "VPS52_MOUSE", "mass": 82044.0, "length": 723, "protein_name": "Vacuolar protein sorting-associated protein 52 homolog", "gene_name": "Vps52", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 52 homolog isoform 1", "refseq_ac": "NP_766208", "gene_names_uniprotkb": "Vps52", "gene_names_refseq": "ARE1; D130068D18; D430041K17Rik; SAC2; Sacm2l; Vps52; tclw5", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 52 homolog", "protein_names_refseq": "vacuolar protein sorting 52; vacuolar protein sorting-associated protein 52 homolog isoform 1; vacuolar protein sorting-associated protein 52 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:224705); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;23142660;30084848;30779550;31219806;31599954;32473257;33300544;34428180;35820727", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane., [UniProtKB, UniProtKB]; The Vps52 subunit of the GARP and EARP complexes is a novel Arf6-interacting protein that negatively regulates neurite outgrowth of hippocampal neurons., [RefSeq, PubMed]; The Vps52 was responsible for the tw5 mutation, and revealed development-specific functions of this gene, which was formerly thought to be solely involved in retrograde endocytic transport., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P4N7;Q8BQ15;Q9QWT6;Q9QWV2", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006605 protein targeting;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0007041 lysosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDG3-1", "uniprot_id": "VCIP1_MOUSE", "mass": 134503.0, "length": 1220, "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "Vcpip1", "organism": "Mouse", "refseq_name": "deubiquitinating protein VCPIP1", "refseq_ac": "NP_775619", "gene_names_uniprotkb": "Vcpip1; Vcip135", "gene_names_refseq": "4932442A08; 5730421J18Rik; 5730538E15Rik; VCIP135; Vcpip1; mKIAA1850", "protein_names_uniprotkb": "Deubiquitinating protein VCPIP1; 3.4.19.12; VCP/p47 complex-interacting 135-kDa protein; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135", "protein_names_refseq": "VCP/p47 complex-interacting 135-kDa protein; deubiquitinating protein VCIP135; deubiquitinating protein VCPIP1; valosin-containing protein p97/p47 complex-interacting protein p135", "tax_id": 10090, "disease": "progeria (Disease Ontology:DOID:3911)", "pathway": " (mmu:70675); (R-MMU-5689896)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;14988733;18250455;21183079;21750661;22517741;22645316;25428506;25605945;26495903;28584101;30016717;31219806;31599954;32782141;32848054;34428180;34678516;35822049;36852467;39627609;40021952;40885482", "class_list": "", "function": "BoNT/A catalytic light chain binds to, and is a substrate for, the ubiquitin ligase HECTD2. However, the light chain evades proteasomal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1. This deubiquitinating enzyme binds BoNT/A light chain directly., [RefSeq, PubMed]; Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (By similarity). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; That p47 ubiquitin regulatory X domain domains may act as general p97/VCP/CDC48 binding modules and that adaptor binding for N-ethylmaleimide sensitive factor and p97 might involve different binding sites, [RefSeq, PubMed]; This gene encodes a deubiquitinating enzyme that interacts with valosin containing protein p97 and plays a role in the assembly of Golgi apparatus during mitosis. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMU9;Q8BP90", "ec_number_list": "2.7.11.22;2.7.11.23;3.4.19.12", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:1905634 regulation of protein localization to chromatin;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q8CDG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3E3-1", "uniprot_id": "WIPI1_MOUSE", "mass": 48758.0, "length": 446, "protein_name": "WD repeat domain phosphoinositide-interacting protein 1", "gene_name": "Wipi1", "organism": "Mouse", "refseq_name": "WD repeat domain phosphoinositide-interacting protein 1", "refseq_ac": "NP_666052", "gene_names_uniprotkb": "Wipi1; D11Ertd498e", "gene_names_refseq": "4930533H01Rik; D11Ertd498e; Wipi1", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa; WIPI-1", "protein_names_refseq": "WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa; WIPI-1", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:52639); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;21896713;22275429;24788674;25428506;31021818;31219806;34428180;36852467;40885482", "class_list": "", "function": "Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:22275429). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes. There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane. Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; WIPI1 is a conserved mediator of right ventricular failure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGE1;Q8R1A9;Q8R1C7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0030331 nuclear estrogen receptor binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034497 protein localization to phagophore assembly site;GO:0009267 cellular response to starvation;GO:0048203 vesicle targeting, trans-Golgi to endosome;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R3E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4T9-1", "uniprot_id": "UT2_MOUSE", "mass": 102047.0, "length": 930, "protein_name": "Urea transporter 2", "gene_name": "Slc14a2", "organism": "Mouse", "refseq_name": "urea transporter 2 isoform d", "refseq_ac": "NP_001103744", "gene_names_uniprotkb": "Slc14a2; Ut2", "gene_names_refseq": "Slc14a2; UT-A1; UT-A3", "protein_names_uniprotkb": "Urea transporter 2; Solute carrier family 14 member 2; Urea transporter, kidney", "protein_names_refseq": "solute carrier family 14 member 2; urea transporter 2 isoform d; urea transporter 2; urea transporter, kidney", "tax_id": 10090, "disease": "", "pathway": " (mmu:27411); (R-MMU-549127)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11029290;11880324;12217874;12952854;21750661;32461256;32661130;33369887;38924449", "class_list": "", "function": "Levels of UTA mRNA were increased in thirsted mice compared with control animals, [RefSeq, PubMed]; Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:11029290). Implicated in the urea movement across the blood-testis barrier and does not translocate water (PubMed:11029290)., [UniProtKB, PubMed]; Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism., [UniProtKB, PubMed, PubMed]; Potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2., [RefSeq, PubMed]; Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3., [RefSeq, PubMed]; The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism., [RefSeq, PubMed]; Urea transporter UT-A1 as a novel drug target for hyponatremia., [RefSeq, PubMed]; Water transport mediated by murine urea transporters: implications for urine concentration mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RWS5;Q8K5D0;Q9ES04;Q9ES05", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0015840 urea transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R4T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBS7-1", "uniprot_id": "V1R42_MOUSE", "mass": 37352.0, "length": 329, "protein_name": "Vomeronasal type-1 receptor 42", "gene_name": "Vmn1r42", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 42", "refseq_ac": "NP_444451", "gene_names_uniprotkb": "Vmn1r42; V1ra10; V1ra1; V1ra3; V1ra6", "gene_names_refseq": "V1ra1; V1ra3; V1ra6; Vmn1r42", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 42; Vomeronasal type-1 receptor A10; Vomeronasal type-1 receptor A1; Vomeronasal type-1 receptor A3; Vomeronasal type-1 receptor A6", "protein_names_refseq": "vomernasal 1 receptor Vmn1r42; vomeronasal receptor 1 A1; vomeronasal receptor 1 A3; vomeronasal receptor V1RA10; vomeronasal type-1 receptor 42; vomeronasal type-1 receptor A10; vomeronasal type-1 receptor A6", "tax_id": 10090, "disease": "", "pathway": " (mmu:113848)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11116090;12214233", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQ49", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VBS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHI6-1", "uniprot_id": "WASF3_MOUSE", "mass": 55204.0, "length": 501, "protein_name": "Actin-binding protein WASF3", "gene_name": "Wasf3", "organism": "Mouse", "refseq_name": "actin-binding protein WASF3 isoform a", "refseq_ac": "NP_660137", "gene_names_uniprotkb": "Wasf3; Wave3", "gene_names_refseq": "Scar3; Wasf3; Wave3", "protein_names_uniprotkb": "Actin-binding protein WASF3; Protein WAVE-3; WASP family protein member 3; Wiskott-Aldrich syndrome protein family member 3", "protein_names_refseq": "WAS protein family, member 3; WASP family protein member 3; actin-binding protein WASF3 isoform a; actin-binding protein WASF3; protein WAVE-3; wiskott-Aldrich syndrome protein family member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:245880); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013149)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12185600;12856283;21750661;31542393;32312818;33594155;40885482", "class_list": "", "function": "Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Required for regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB]; Elevated WASF3 Expression Promotes Metastasis in Breast Cancer., [RefSeq, PubMed]; Our work suggests that PCARE is an actin-associated protein that interacts with WASF3 to regulate the actin-driven expansion of the ciliary membrane at the initiation of new outer segment disk formation., [RefSeq, PubMed]; Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer. Erratum:[Sci Rep. 2021 Jul 29;11(1):15800. doi: 10.1038/s41598-021-94981-0. PMID: 34326443] Publication Status: Online-Only, [RefSeq, PubMed]; WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0098794 postsynapse;GO:0031209 SCAR complex", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VHI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHL0-1", "uniprot_id": "UT1_MOUSE", "mass": 42126.0, "length": 384, "protein_name": "Urea transporter 1", "gene_name": "Slc14a1", "organism": "Mouse", "refseq_name": "urea transporter 1 isoform a", "refseq_ac": "NP_001164481", "gene_names_uniprotkb": "Slc14a1", "gene_names_refseq": "2610507K20Rik; 3021401A05Rik; Slc14a1; UT-B; Utb1", "protein_names_uniprotkb": "Urea transporter 1; Solute carrier family 14 member 1; UT-B; Urea transporter B; Urea transporter, erythrocyte", "protein_names_refseq": "solute carrier family 14 member 1; urea transporter 1 isoform a; urea transporter 1; urea transporter B; urea transporter, erythrocyte", "tax_id": 10090, "disease": "", "pathway": " (mmu:108052); (R-MMU-549127)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11792714;12133842;12952854;12965892;15563580;33675462", "class_list": "", "function": "Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells., [RefSeq, PubMed]; Mediates the transport of urea driven by a concentration gradient across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (PubMed:11792714). Facilitates water transport in erythrocytes (PubMed:12133842)., [UniProtKB, PubMed, PubMed]; Potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2, [RefSeq, PubMed]; UT-B has a role in urinary concentrating ability in mice, [RefSeq, PubMed]; UT-B-deficient mice reveal that countercurrent exchange of urea in renal medullary vessels and red blood cells accounts for a major part of the kidney's concentrating ability and for the adaptation of renal urea handling during a high-protein intake., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U542;Q497G1;Q5RJG2;Q6PDP4;Q9CZX3", "ec_number_list": "", "go_molecular_function": "GO:0005372 water transmembrane transporter activity;GO:0015265 urea channel activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0006833 water transport;GO:0015840 urea transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VHL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YD6-1", "uniprot_id": "VILL_MOUSE", "mass": 96509.0, "length": 859, "protein_name": "Villin-like protein", "gene_name": "Vill", "organism": "Mouse", "refseq_name": "villin-like protein isoform 1", "refseq_ac": "NP_001158039", "gene_names_uniprotkb": "Vill; Villp", "gene_names_refseq": "Villp; Vill", "protein_names_uniprotkb": "Villin-like protein; EF-6", "protein_names_refseq": "EF-6; villin-like protein isoform 1; villin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:22351)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15576363;21750661;30084848;9032278", "class_list": "", "function": "H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin, [RefSeq, PubMed]; Possible tumor suppressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97809;Q8BIS5;Q8R211;Q8VDI8", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0051014 actin filament severing;GO:0007010 cytoskeleton organization;GO:0051693 actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91YD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZJ5-1", "uniprot_id": "UGPA_MOUSE", "mass": 56979.0, "length": 508, "protein_name": "UTP--glucose-1-phosphate uridylyltransferase", "gene_name": "Ugp2", "organism": "Mouse", "refseq_name": "UTP--glucose-1-phosphate uridylyltransferase isoform 2", "refseq_ac": "NP_001277563", "gene_names_uniprotkb": "Ugp2", "gene_names_refseq": "UDPGP; UGPase; Ugp2", "protein_names_uniprotkb": "UTP--glucose-1-phosphate uridylyltransferase; 2.7.7.9; UDP-glucose pyrophosphorylase; UDPGP; UGPase", "protein_names_refseq": "UTP--glucose-1-phosphate uridylyltransferase isoform 2; UTP--glucose-1-phosphate uridylyltransferase; uridindiphosphoglucosepyrophosphorylase 2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 83 (Disease Ontology:DOID:0112218); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:216558); (R-MMU-173599); (R-MMU-3322077)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12174196;21183079;30084848;34428180;36288343;37453647;37507081;39927985", "class_list": "glycogene", "function": "UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3D2", "ec_number_list": "2.7.7.9", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity;GO:0032557 pyrimidine ribonucleotide binding;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0007420 brain development;GO:0005978 glycogen biosynthetic process;GO:0019255 glucose 1-phosphate metabolic process;GO:0006011 UDP-alpha-D-glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91ZJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L60-1", "uniprot_id": "VATC2_MOUSE", "mass": 48350.0, "length": 427, "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "Atp6v1c2", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit C 2 isoform 1", "refseq_ac": "NP_001153104", "gene_names_uniprotkb": "Atp6v1c2; Atp6c2", "gene_names_refseq": "1110038G14Rik; Atp6v1c2", "protein_names_uniprotkb": "V-type proton ATPase subunit C 2; V-ATPase subunit C 2; Vacuolar proton pump subunit C 2", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit C; V-ATPase subunit C 2; V-type proton ATPase subunit C 2 isoform 1; V-type proton ATPase subunit C 2; vacuolar proton pump subunit C 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:68775); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "12527205;12947086;21750661;37507081", "class_list": "", "function": "Results suggest that V-ATPases with the C2-a and C2-b isoform are involved in luminal acidification of lamellar bodies and regulation of the renal acid-base balance, respectively, [RefSeq, PubMed]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHA4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180 proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99L60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQD8-1", "uniprot_id": "VA0E1_MOUSE", "mass": 9340.0, "length": 81, "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "Atp6v0e1; Atp6v0e", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit e 1", "refseq_ac": "NP_079548", "gene_names_uniprotkb": "Atp6v0e1; Atp6v0e; Atp6v0e", "gene_names_refseq": "Atp6k; Atp6v0e1; Atp6v0e; M9.2", "protein_names_uniprotkb": "V-type proton ATPase subunit e 1; V-ATPase subunit e 1; Vacuolar proton pump subunit e 1", "protein_names_refseq": "ATPase, H+ transporting lysosomal (vacuolar proton pump), 9.2 kDa; ATPase, H+ transporting, V0 subunit e; ATPase, H+ transporting, lysosomal 9kD V0 subunit E; V-ATPase subunit e 1; V-type proton ATPase subunit e 1; lysosomal 9kDa; vacuolar proton pump subunit e 1", "tax_id": 10090, "disease": "blindness (Disease Ontology:DOID:1432)", "pathway": " (mmu:11974); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12544825;21750661;31219806;34428180", "class_list": "", "function": "A cDNA encoding a novel putative neuron-specific isoform of vacuolar proton-translocating ATPase (V-ATPase), NM9.2, was isolated from rat and mouse., [RefSeq, PubMed]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033179 proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D132-1", "uniprot_id": "UPK1A_MOUSE", "mass": 28854.0, "length": 257, "protein_name": "Uroplakin-1a", "gene_name": "Upk1a", "organism": "Mouse", "refseq_name": "uroplakin-1a", "refseq_ac": "NP_081091", "gene_names_uniprotkb": "Upk1a", "gene_names_refseq": "1110031P12Rik; Tspan21; Upk1a; Upk1", "protein_names_uniprotkb": "Uroplakin-1a; UP1a; UPIa; UPKa; Uroplakin Ia", "protein_names_refseq": "UP1a; UPIa; UPKa; uroplakin Ia; uroplakin-1a", "tax_id": 10090, "disease": "", "pathway": " (mmu:109637)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11718558;11739641;36042152", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)., [UniProtKB]; Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography, [RefSeq, PubMed]; Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity, Decreased Bacterial Clearance Capacity, and Drastic Changes in the Testicular Transcriptome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D132-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EP82-1", "uniprot_id": "WDR4_MOUSE", "mass": 45756.0, "length": 413, "protein_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "gene_name": "Wdr4", "organism": "Mouse", "refseq_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform a", "refseq_ac": "NP_067297", "gene_names_uniprotkb": "Wdr4", "gene_names_refseq": "D530049K22Rik; Wdr4; Wh; mWH", "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Protein Wuho homolog; WD repeat-containing protein 4; mWH", "protein_names_refseq": "WD repeat-containing protein 4; WD40 repeat protein 4; protein Wuho homolog; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform a; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); microcephaly, growth deficiency, seizures, and brain malformations (Disease Ontology:DOID:0081051)", "pathway": " (mmu:57773)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10950928;21750661;25153642;26751069;29574139;29983320;31219806", "class_list": "", "function": "Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:29983320). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (By similarity). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:29983320). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (By similarity). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (By similarity). Also required for methylation of a specific subset of miRNAs, such as let-7 (By similarity). Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:29574139)., [UniProtKB, HAMAP, PubMed, PubMed]; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit., [UniProtKB, HAMAP]; WDR4 protein deficiency would induces gammaH2AX protein level elevation, heterochromatin relaxation and DNA damage down-stream sequences, including p53 activation, caspase-mediated apoptotic pathway, and p21-mediated G2/M cell cycle arrest., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80V01", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0141106 tRNA methyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0006974 DNA damage response;GO:0106004 tRNA (guanine-N7)-methylation;GO:0036416 tRNA stabilization;GO:0036265 RNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9EP82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ45-1", "uniprot_id": "V1R46_MOUSE", "mass": 35006.0, "length": 309, "protein_name": "Vomeronasal type-1 receptor 46", "gene_name": "Vmn1r46", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 46", "refseq_ac": "NP_444459", "gene_names_uniprotkb": "Vmn1r46; V1ra13; V1rb8", "gene_names_refseq": "V1rb8; Vmn1r46", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 46; Vomeronasal type-1 receptor A13; Vomeronasal type-1 receptor B8", "protein_names_refseq": "vomernasal 1 receptor Vmn1r46; vomeronasal 1 receptor, B8; vomeronasal type 1 receptor B8; vomeronasal type-1 receptor 46; vomeronasal type-1 receptor A13", "tax_id": 10090, "disease": "", "pathway": " (mmu:113856)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11116090;12214233", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQ45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ48-1", "uniprot_id": "VN1A8_MOUSE", "mass": 31564.0, "length": 279, "protein_name": "Vomeronasal type-1 receptor A8", "gene_name": "V1ra8", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor A8", "refseq_ac": "NP_444453", "gene_names_uniprotkb": "V1ra8", "gene_names_refseq": "V1ra8; Vmn1r-ps33", "protein_names_uniprotkb": "Vomeronasal type-1 receptor A8", "protein_names_refseq": "vomeronasal type-1 receptor A8", "tax_id": 10090, "disease": "", "pathway": " (mmu:113850)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11116090;11802169;12214233;35820727", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EHS8", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EQ48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0C8-1", "uniprot_id": "VAV3_MOUSE", "mass": 97968.0, "length": 847, "protein_name": "Guanine nucleotide exchange factor VAV3", "gene_name": "Vav3", "organism": "Mouse", "refseq_name": "guanine nucleotide exchange factor VAV3 isoform 1", "refseq_ac": "NP_065251", "gene_names_uniprotkb": "Vav3", "gene_names_refseq": "A530094I06Rik; Idd18.1; Vav3", "protein_names_uniprotkb": "Guanine nucleotide exchange factor VAV3; VAV-3", "protein_names_refseq": "VAV-3; guanine nucleotide exchange factor VAV3 isoform 1; guanine nucleotide exchange factor VAV3; vav 3 oncogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:57257); (R-MMU-114604); (R-MMU-193648); (R-MMU-2029482); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-3928665); (R-MMU-416482); (R-MMU-4420097); (R-MMU-5218920); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9748787)", "pathway_count": 17, "publication_count": 15, "publication_id_list": "10713454;15249579;15365099;15711558;16782872;19147786;20173027;25428506;30084848;31219806;31599954;34203471;34428180;35534539;35820727", "class_list": "", "function": "Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion., [UniProtKB, PubMed, PubMed, PubMed]; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function., [RefSeq, PubMed]; Three Vav proteins (vav1,vav2 and vav3) function specifically in distinct pathways that trigger NK cell cytotoxicity., [RefSeq, PubMed]; Vav1 and Vav3 proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2CFD7;Q7TS85;Q8BRV2;Q8CCF5;Q8R076;Q9JLS6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0001772 immunological synapse", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0045785 positive regulation of cell adhesion;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9R0C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1Z8-1", "uniprot_id": "VINEX_MOUSE", "mass": 82349.0, "length": 733, "protein_name": "Vinexin", "gene_name": "Sorbs3", "organism": "Mouse", "refseq_name": "vinexin isoform a", "refseq_ac": "NP_035496", "gene_names_uniprotkb": "Sorbs3; Scam1; Sh3d4", "gene_names_refseq": "SCAM-1; SH3P3; Sh3d4; Sorbs3; vinexin-g", "protein_names_uniprotkb": "Vinexin; SCAM-1; SH3 domain-containing protein SH3P3; SH3-containing adapter molecule 1; Sorbin and SH3 domain-containing protein 3", "protein_names_refseq": "SH3 domain protein 4; SH3 domain-containing protein SH3P3; SH3-containing adapter molecule 1; vinexin alpha; vinexin beta; vinexin isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:20410); (R-MMU-445355)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11825889;12657639;15184391;15242778;17242355;21183079;21750661;30578314;32782141;34848853;35104662;35822241;37828378;9630982;9885244", "class_list": "", "function": "Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling., [RefSeq, PubMed]; Promotes up-regulation of actin stress fiber formation., [UniProtKB]; Regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor, [RefSeq, PubMed]; These results demonstrate that the H2 helix in vinexin alpha plays a critical role in ECM stiffness-dependent regulation of vinculin and cell behaviors. Publication Status: Online-Only, [RefSeq, PubMed]; Vinexin beta deficiency exacerbates diet-induced obesity, hepatosteatosis, insulin resistance and endoplasmic reticulum stress in mice., [RefSeq, PubMed]; Vinexin contributes to autophagic decline in brain ageing across species., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62423", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0017166 vinculin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043410 positive regulation of MAPK cascade;GO:0007010 cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0031589 cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9R1Z8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTZ0-1", "uniprot_id": "UXT_MOUSE", "mass": 18187.0, "length": 157, "protein_name": "Protein UXT", "gene_name": "Uxt", "organism": "Mouse", "refseq_name": "protein UXT isoform 1", "refseq_ac": "NP_038868", "gene_names_uniprotkb": "Uxt", "gene_names_refseq": "0910002B17Rik; Uxt", "protein_names_uniprotkb": "Protein UXT; Ubiquitously expressed transcript protein", "protein_names_refseq": "protein UXT isoform 1; protein UXT; ubiquitously expressed transcript protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:22294)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10087202;17620405;21307340;28106301;29649254;31219806;32678429;32744119;34428180;36210013;36852467", "class_list": "", "function": "Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM., [UniProtKB, UniProtKB]; Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation., [RefSeq, PubMed]; Our study has revealed the first in vivo function for UXT in the mammalian germline as a regulator of distinct transcriptional programs in SSCs and differentiating spermatogonia. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in protecting cells against TNF-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP., [UniProtKB, PubMed]; UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells., [RefSeq, PubMed]; UXT in Sertoli cells is required for blood-testis barrier integritydagger., [RefSeq, PubMed]; Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation., [RefSeq, PubMed]; Uxt is a novel and essential cofactor in the NF-kappa B transcriptional enhanceosome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEJ2", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0006915 apoptotic process;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9WTZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0K8-1", "uniprot_id": "VNN1_MOUSE", "mass": 57091.0, "length": 512, "protein_name": "Pantetheinase", "gene_name": "Vnn1", "organism": "Mouse", "refseq_name": "pantetheinase isoform 1 precursor", "refseq_ac": "NP_035834", "gene_names_uniprotkb": "Vnn1", "gene_names_refseq": "V-1; Vnn1", "protein_names_uniprotkb": "Pantetheinase; 3.5.1.92; Pantetheine hydrolase; Vanin-1; Vascular non-inflammatory molecule 1", "protein_names_refseq": "pantetheinase isoform 1 precursor; pantetheinase; pantetheine hydrolase; vascular non-inflammatory molecule 1", "tax_id": 10090, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (mmu:22361); (R-MMU-163125); (R-MMU-199220); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10567687;11042271;30059200;30084848;34428180;37114564;38246587;8934567", "class_list": "", "function": "Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine., [UniProtKB, PubMed]; Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction., [RefSeq, PubMed]; VNN1 overexpression in pancreatic cancer cells inhibits paraneoplastic islet function by increasing oxidative stress and inducing beta-cell dedifferentiation., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJI0;Q8VCT1;Q9DCH8", "ec_number_list": "3.4.11.9;3.1.3.1;3.1.4.50;3.9.1.1;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.6.5.2;3.4.23.-;3.2.1.20;7.6.2.1;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;7.6.2.-;3.2.2.6;3.4.16.2;3.4.17.12;3.1.3.5;3.1.3.2;3.1.3.48;3.2.1.25;2.4.2.31;2.5.1.18;3.4.21.-;3.5.1.92", "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0017159 pantetheine hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0015939 pantothenate metabolic process;GO:0045087 innate immune response;GO:0033089 positive regulation of T cell differentiation in thymus;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z0K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69Z99-1", "uniprot_id": "ZN512_MOUSE", "mass": 63908.0, "length": 562, "protein_name": "Zinc finger protein 512", "gene_name": "Zfp512; Znf512", "organism": "Mouse", "refseq_name": "zinc finger protein 512 isoform 1", "refseq_ac": "NP_766581", "gene_names_uniprotkb": "Zfp512; Znf512; Kiaa1805; Zfp512", "gene_names_refseq": "2500002M11Rik; D230008H22; Zfp512; Znf512", "protein_names_uniprotkb": "Zinc finger protein 512", "protein_names_refseq": "zinc finger protein 512 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269639)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28528544;38961301", "class_list": "", "function": "Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U365;Q3UDU3;Q3UJQ0;Q5FWY0;Q8BJF3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0140719 constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q69Z99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0C5-1", "uniprot_id": "ZG16_MOUSE", "mass": 18210.0, "length": 167, "protein_name": "Zymogen granule membrane protein 16", "gene_name": "Zg16", "organism": "Mouse", "refseq_name": "zymogen granule membrane protein 16 precursor", "refseq_ac": "NP_081194", "gene_names_uniprotkb": "Zg16", "gene_names_refseq": "1810010M01Rik; ZG16p; Zg16", "protein_names_uniprotkb": "Zymogen granule membrane protein 16; Secretory lectin ZG16; Zymogen granule protein 16", "protein_names_refseq": "secretory lectin ZG16; zymogen granule membrane protein 16 precursor; zymogen granule membrane protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:69036)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15097871;21750661;27849619;30084848;39191121", "class_list": "", "function": "May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (By similarity)., [UniProtKB]; The more penetrable Zg16(-/-) mucus allowed Gram-positive bacteria to translocate to systemic tissues. Viable bacteria were found in spleen and were associated with increased abdominal fat pad mass in Zg16(-/-) animals. The function of ZG16 reveals a mechanism for keeping bacteria further away from the host colon epithelium., [RefSeq, PubMed]; ZG16 impacts gut microbiota-associated intestinal inflammation and pulmonary mucosal function through bacterial metabolites., [RefSeq, PubMed]; ZG16p mRNA is downregulated in chronic pancreatitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0070701 mucus layer;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0042589 zymogen granule membrane", "go_biological_process": "GO:0015031 protein transport;GO:0050830 defense response to Gram-positive bacterium;GO:0052373 suppression of symbiont entry into host", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K0C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCB3-1", "uniprot_id": "RN227_MOUSE", "mass": 20820.0, "length": 190, "protein_name": "RING finger protein 227", "gene_name": "Rnf227", "organism": "Mouse", "refseq_name": "RING finger protein 227", "refseq_ac": "NP_001400402", "gene_names_uniprotkb": "Rnf227; Chd3os; MNCb-2875", "gene_names_refseq": "2310043C11Rik; A030009H04Rik; Chd3os; MNCb-2875; RNF21; Rnf227", "protein_names_uniprotkb": "RING finger protein 227", "protein_names_refseq": "Chd3 opposite strand transcript; RING finger protein 227; chromodomain helicase DNA binding protein 3, opposite strand", "tax_id": 10090, "disease": "", "pathway": " (mmu:80515)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LI80;Q9JJ82", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DCB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54692-1", "uniprot_id": "ZW10_MOUSE", "mass": 88063.0, "length": 779, "protein_name": "Centromere/kinetochore protein zw10 homolog", "gene_name": "Zw10", "organism": "Mouse", "refseq_name": "centromere/kinetochore protein zw10 homolog", "refseq_ac": "NP_036169", "gene_names_uniprotkb": "Zw10", "gene_names_refseq": "6330566F14Rik; MmZw10; Zw10", "protein_names_uniprotkb": "Centromere/kinetochore protein zw10 homolog", "protein_names_refseq": "ZW10 homolog, centromere/kinetochore protein; centromere/kinetochore protein zw10 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:26951); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-6811434); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;19224205;20173027;21750661;22872234;25153642;25428506;25605945;30084848;30779550;31219806;31250100;31599954;34428180;36210013;9298984", "class_list": "", "function": "Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity)., [UniProtKB, UniProtKB]; Results demonstrate that Zw10 is localized at kinetochores and functions as an essential spindle assembly checkpoint component in mouse oocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIA5;Q3ULW1;Q921H3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:1990423 RZZ complex;GO:0070939 Dsl1/NZR complex;GO:0000922 spindle pole;GO:0005634 nucleus", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O54692-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BFL2-1", "uniprot_id": "ZY11A_MOUSE", "mass": 70404.0, "length": 627, "protein_name": "Protein zyg-11 homolog A", "gene_name": "Zyg11a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zyg11a", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein zyg-11 homolog A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:230590)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probably acts as a target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC01", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BFL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AKY4-1", "uniprot_id": "Z804A_MOUSE", "mass": 134850.0, "length": 1200, "protein_name": "Zinc finger protein 804A", "gene_name": "Znf804a", "organism": "Mouse", "refseq_name": "zinc finger protein 804A", "refseq_ac": "NP_780722", "gene_names_uniprotkb": "Znf804a; Zfp804a", "gene_names_refseq": "C630007C17Rik; Zfp804a; Znf804a", "protein_names_uniprotkb": "Zinc finger protein 804A", "protein_names_refseq": "zinc finger protein 804A", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:241514)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "33303946;33446247;35820727", "class_list": "", "function": "Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development. Publication Status: Online-Only, [RefSeq, PubMed]; ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHY7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:1902952 positive regulation of dendritic spine maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AKY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q65Z93-1", "uniprot_id": "YPEL4_MOUSE", "mass": 14315.0, "length": 127, "protein_name": "Protein yippee-like 4", "gene_name": "Ypel4", "organism": "Mouse", "refseq_name": "protein yippee-like 4", "refseq_ac": "NP_001005342", "gene_names_uniprotkb": "Ypel4; Ypel", "gene_names_refseq": "Ypel4", "protein_names_uniprotkb": "Protein yippee-like 4", "protein_names_refseq": "protein yippee-like 4", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:241525)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15556292;21750661;34354145", "class_list": "", "function": "Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0008360 regulation of cell shape;GO:0045647 negative regulation of erythrocyte differentiation;GO:0034107 negative regulation of erythrocyte clearance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q65Z93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPP0-1", "uniprot_id": "ZN436_MOUSE", "mass": 52363.0, "length": 452, "protein_name": "Zinc finger protein 436", "gene_name": "Zfp46; Znf436", "organism": "Mouse", "refseq_name": "zinc finger protein 436 isoform 1", "refseq_ac": "NP_033583", "gene_names_uniprotkb": "Zfp46; Znf436; Kiaa1710; Mlz-4; Zfp46", "gene_names_refseq": "Mlz-4; Zfp-46; Zfp46; Znf436", "protein_names_uniprotkb": "Zinc finger protein 436; Zfp-46; Zinc finger protein 46; Zinc finger protein MLZ-4", "protein_names_refseq": "zinc finger protein 436 isoform 1; zinc finger protein 436; zinc finger protein MLZ-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:22704); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;8444344", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q03309;Q69ZC6;Q8BQC2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BPP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TDE8-1", "uniprot_id": "ZN691_MOUSE", "mass": 32199.0, "length": 283, "protein_name": "Zinc finger protein 691", "gene_name": "Zfp691; Znf691", "organism": "Mouse", "refseq_name": "zinc finger protein 691", "refseq_ac": "NP_001139407", "gene_names_uniprotkb": "Zfp691; Znf691; Zfp691", "gene_names_refseq": "6430544H17Rik; Zfp691; Znf691", "protein_names_uniprotkb": "Zinc finger protein 691", "protein_names_refseq": "zinc finger protein 691", "tax_id": 10090, "disease": "", "pathway": " (mmu:195522); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAT2;Q8BIB1", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TDE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61751-1", "uniprot_id": "Z354A_MOUSE", "mass": 65662.0, "length": 572, "protein_name": "Zinc finger protein 354A", "gene_name": "Zfp354a; Znf354a", "organism": "Mouse", "refseq_name": "zinc finger protein 354A isoform 2", "refseq_ac": "NP_001313495", "gene_names_uniprotkb": "Zfp354a; Znf354a; Kid1; Tcf17; Zfp354a", "gene_names_refseq": "Tcf17; Zfp354a; Znf354a; kid1", "protein_names_uniprotkb": "Zinc finger protein 354A; Kidney, ischemia, and developmentally-regulated protein 1; Renal transcription factor Kid-1; TCF-17; Transcription factor 17", "protein_names_refseq": "kidney, ischemia, and developmentally-regulated protein 1; renal transcription factor Kid-1; transcription factor 17; zinc finger protein 354A isoform 2", "tax_id": 10090, "disease": "seminoma (Disease Ontology:DOID:4440); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:21408); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10564808;21750661;25428506;30084848;9176064", "class_list": "", "function": "It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXU0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007000 nucleolus organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2KFW1-1", "uniprot_id": "ZSC20_MOUSE", "mass": 115379.0, "length": 1030, "protein_name": "Zinc finger and SCAN domain-containing protein 20", "gene_name": "Zscan20", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain-containing protein 20", "refseq_ac": "NP_808426", "gene_names_uniprotkb": "Zscan20; Zfp31", "gene_names_refseq": "C130001F22; Zfp31; Zkscan20; Zscan20", "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 20; Zinc finger protein 31", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 20; zinc finger protein 31; zinc finger with KRAB and SCAN domains 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:269585)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AS93;Q3UNF0;Q6DFW6;Q8BJ07", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2KFW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61237-1", "uniprot_id": "YPEL3_MOUSE", "mass": 13608.0, "length": 119, "protein_name": "Protein yippee-like 3", "gene_name": "Ypel3", "organism": "Mouse", "refseq_name": "protein yippee-like 3 isoform a", "refseq_ac": "NP_079623", "gene_names_uniprotkb": "Ypel3; Suap; Ypel", "gene_names_refseq": "0610043B10Rik; 1190001G19Rik; Suap; Ypel3", "protein_names_uniprotkb": "Protein yippee-like 3; Small ubiquitinated apoptotic protein", "protein_names_refseq": "protein yippee-like 3 isoform a; protein yippee-like 3; small ubiquitinated apoptotic protein", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:66090)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12566317;15556292;21196260;21750661;25605945;34428180;36210013", "class_list": "", "function": "Involved in proliferation and apoptosis in myeloid precursor cells., [UniProtKB, PubMed]; Studies with mouse YPEL3, originally named small unstable apoptotic protein (SUAP), confirmed that the gene encodes a growth suppressive highly unstable protein.[review] Review article Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q71E85;Q9BSJ4;Q9CQB6;Q9D0U3", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006915 apoptotic process;GO:2000774 positive regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61237-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V080-1", "uniprot_id": "ZN583_MOUSE", "mass": 65709.0, "length": 568, "protein_name": "Zinc finger protein 583", "gene_name": "Zfp583; Znf583", "organism": "Mouse", "refseq_name": "zinc finger protein 583", "refseq_ac": "NP_001028421", "gene_names_uniprotkb": "Zfp583; Znf583; Zfp583", "gene_names_refseq": "Zfp583; Znf583", "protein_names_uniprotkb": "Zinc finger protein 583", "protein_names_refseq": "zinc finger protein 583", "tax_id": 10090, "disease": "", "pathway": " (mmu:213011); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3L4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V080-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKK5-1", "uniprot_id": "ZN689_MOUSE", "mass": 57082.0, "length": 500, "protein_name": "Zinc finger protein 689", "gene_name": "Zfp689; Znf689", "organism": "Mouse", "refseq_name": "zinc finger protein 689", "refseq_ac": "NP_780372", "gene_names_uniprotkb": "Zfp689; Znf689; Zfp689", "gene_names_refseq": "4933416E05Rik; Zfp689; Znf689", "protein_names_uniprotkb": "Zinc finger protein 689", "protein_names_refseq": "zinc finger protein 689", "tax_id": 10090, "disease": "", "pathway": " (mmu:71131); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1C6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BKK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB43-1", "uniprot_id": "ZFPL1_MOUSE", "mass": 34155.0, "length": 310, "protein_name": "Zinc finger protein-like 1", "gene_name": "Zfpl1", "organism": "Mouse", "refseq_name": "zinc finger protein-like 1", "refseq_ac": "NP_077193", "gene_names_uniprotkb": "Zfpl1", "gene_names_refseq": "Zfpl1", "protein_names_uniprotkb": "Zinc finger protein-like 1", "protein_names_refseq": "zinc finger protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:81909)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Required for cis-Golgi integrity and efficient ER to Golgi transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DB43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1D9-1", "uniprot_id": "ZN394_MOUSE", "mass": 59038.0, "length": 521, "protein_name": "Zinc finger protein 394", "gene_name": "Zkscan14; Znf394", "organism": "Mouse", "refseq_name": "zinc finger protein 394", "refseq_ac": "NP_075811", "gene_names_uniprotkb": "Zkscan14; Znf394; Zfp94; Zfp99; Zkscan14", "gene_names_refseq": "2310046C23Rik; 2810437E14Rik; Zfp99; Zkscan14; Znf394", "protein_names_uniprotkb": "Zinc finger protein 394; Zfp-94; Zinc finger protein 94; Zinc finger protein with KRAB and SCAN domains 14", "protein_names_refseq": "zfp-94; zinc finger protein 394; zinc finger protein 94; zinc finger protein 99; zinc finger protein with KRAB and SCAN domains 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:67235); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12860387;21750661;35247902", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EIZ4;Q3U4Z1;Q9CYV9;Q9CZG8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1D9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1D1-1", "uniprot_id": "ZN426_MOUSE", "mass": 63020.0, "length": 550, "protein_name": "Zinc finger protein 426", "gene_name": "Zfp426; Znf426", "organism": "Mouse", "refseq_name": "zinc finger protein 426 isoform 1", "refseq_ac": "NP_001103779", "gene_names_uniprotkb": "Zfp426; Znf426; Kiaa4237; Zfp426", "gene_names_refseq": "2900057C04Rik; KRAB1; Zfo61; Zfp426; Zfp68-rs1; Znf426; mKIAA4237", "protein_names_uniprotkb": "Zinc finger protein 426", "protein_names_refseq": "zinc finger protein 426 isoform 1; zinc finger protein 68, related sequence 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:235028); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTF7;Q8BJ29;Q8CIG1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R1D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0G7-1", "uniprot_id": "ZBT22_MOUSE", "mass": 66029.0, "length": 638, "protein_name": "Zinc finger and BTB domain-containing protein 22", "gene_name": "Zbtb22", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 22", "refseq_ac": "NP_065650", "gene_names_uniprotkb": "Zbtb22; Bing1; Zfp297; Znf297", "gene_names_refseq": "1110008J20Rik; Bing1; Zbtb22; Zfp297", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 22; Protein BING1; Zinc finger protein 297", "protein_names_refseq": "zinc finger and BTB domain-containing protein 22; zinc finger protein 297", "tax_id": 10090, "disease": "", "pathway": " (mmu:81630)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;35820727;37154299", "class_list": "", "function": "Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1-driven gluconeogenesis., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z0G7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60736-1", "uniprot_id": "ZP3R_MOUSE", "mass": 64950.0, "length": 579, "protein_name": "Zona pellucida sperm-binding protein 3 receptor", "gene_name": "Zp3r", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zp3r; Sp56", "gene_names_refseq": "", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 3 receptor; Sperm fertilization protein 56; sp56", "protein_names_refseq": "", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "11133656;21750661;7604284;8188752", "class_list": "", "function": "Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0001669 acrosomal vesicle;GO:0044297 cell body", "go_biological_process": "GO:0009609 response to symbiotic bacterium;GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0045732 positive regulation of protein catabolic process;GO:0045959 negative regulation of complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60736-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R060-1", "uniprot_id": "ZWILC_MOUSE", "mass": 66839.0, "length": 589, "protein_name": "Protein zwilch homolog", "gene_name": "Zwilch", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zwilch", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein zwilch homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:68014); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2E4;Q9D761", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990423 RZZ complex;GO:0000776 kinetochore", "go_biological_process": "GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1M2-1", "uniprot_id": "ZN428_MOUSE", "mass": 19003.0, "length": 176, "protein_name": "Zinc finger protein 428", "gene_name": "Zfp428; Znf428", "organism": "Mouse", "refseq_name": "zinc finger protein 428 isoform a", "refseq_ac": "NP_001277390", "gene_names_uniprotkb": "Zfp428; Znf428; Zfp428", "gene_names_refseq": "2410005H09Rik; Zfp428; Znf428", "protein_names_uniprotkb": "Zinc finger protein 428", "protein_names_refseq": "zinc finger protein 428 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:232969)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9V1;Q8QZT0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C1M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U3I9-1", "uniprot_id": "ZN865_MOUSE", "mass": 111676.0, "length": 1058, "protein_name": "Zinc finger protein 865", "gene_name": "Zfp865; Znf865", "organism": "Mouse", "refseq_name": "zinc finger protein 865 isoform 1", "refseq_ac": "NP_001028555", "gene_names_uniprotkb": "Zfp865; Znf865; Zfp865", "gene_names_refseq": "6430526N21Rik; Zfp865; Znf865", "protein_names_uniprotkb": "Zinc finger protein 865", "protein_names_refseq": "zinc finger protein 865 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319748)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;28528544;30084848;31219806;32848054;34428180;36210013;36852467;37989982", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D3Z3M5", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3U3I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10925-1", "uniprot_id": "ZFY1_MOUSE", "mass": 88230.0, "length": 782, "protein_name": "Zinc finger Y-chromosomal protein 1", "gene_name": "Zfy1", "organism": "Mouse", "refseq_name": "zinc finger Y-chromosomal protein 1", "refseq_ac": "NP_033596", "gene_names_uniprotkb": "Zfy1; Zfy-1", "gene_names_refseq": "Zfy-1; Zfy1; Zfy2", "protein_names_uniprotkb": "Zinc finger Y-chromosomal protein 1", "protein_names_refseq": "Y-linked zinc finger protein 1; Y-linked zinc finger protein 2; zinc finger Y-chromosomal protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22767)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2497440;28251288;35293998", "class_list": "", "function": "Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility., [RefSeq, PubMed]; Our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati, [RefSeq, PubMed]; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKM5;Q8C638", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10925-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3T9Z9-1", "uniprot_id": "ZUP1_MOUSE", "mass": 65593.0, "length": 577, "protein_name": "Zinc finger-containing ubiquitin peptidase 1", "gene_name": "Zup1", "organism": "Mouse", "refseq_name": "zinc finger-containing ubiquitin peptidase 1 isoform 2", "refseq_ac": "NP_082563", "gene_names_uniprotkb": "Zup1; Zufsp", "gene_names_refseq": "2700019D07Rik; DUB; Zufsp; Zup1", "protein_names_uniprotkb": "Zinc finger-containing ubiquitin peptidase 1; 3.4.19.12; DUB; Lys-63-specific deubiquitinase ZUFSP; Zinc finger with UFM1-specific peptidase domain protein", "protein_names_refseq": "lys-63-specific deubiquitinase ZUFSP; ubiquitin carboxyl-terminal hydrolase ZUFSP; zinc finger with UFM1-specific peptidase domain protein; zinc finger-containing ubiquitin peptidase 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72580)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;35820727;38460305", "class_list": "", "function": "Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWB1;Q6NXI1;Q8BJZ1;Q8BK40;Q8BKH3;Q8BL75;Q9CSP5", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3T9Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U381-1", "uniprot_id": "ZN692_MOUSE", "mass": 59010.0, "length": 531, "protein_name": "Zinc finger protein 692", "gene_name": "Znf692", "organism": "Mouse", "refseq_name": "zinc finger protein 692", "refseq_ac": "NP_001035776", "gene_names_uniprotkb": "Znf692; AREBP; Zfp692", "gene_names_refseq": "Zfp692-ps; Zfp692; Znf692", "protein_names_uniprotkb": "Zinc finger protein 692; AICAR responsive element binding protein", "protein_names_refseq": "AICAR responsive element binding protein; zinc finger protein 692, pseudogene; zinc finger protein 692", "tax_id": 10090, "disease": "", "pathway": " (mmu:103836)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21910974;31219806", "class_list": "", "function": "AREBP is a key modulator of hepatic glucose production regulated by AMPK in vivo., [RefSeq, PubMed]; May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006111 regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFS0-1", "uniprot_id": "ZY11B_MOUSE", "mass": 83991.0, "length": 744, "protein_name": "Protein zyg-11 homolog B", "gene_name": "Zyg11b", "organism": "Mouse", "refseq_name": "protein zyg-11 homolog B isoform 1", "refseq_ac": "NP_001028806", "gene_names_uniprotkb": "Zyg11b; Kiaa1730", "gene_names_refseq": "1110046I03Rik; 2810482G21Rik; D4Mgi23; Gm431; Zyg11b; mKIAA1730", "protein_names_uniprotkb": "Protein zyg-11 homolog B", "protein_names_refseq": "protein zyg-11 homolog B isoform 1; protein zyg-11 homolog B; zyg-ll homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:414872)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redundantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EID5;Q148T6;Q3TM33;Q3TMB0;Q3TRM3;Q3UFA3;Q80TA0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UFS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URR7-1", "uniprot_id": "ZSC10_MOUSE", "mass": 88355.0, "length": 782, "protein_name": "Zinc finger and SCAN domain-containing protein 10", "gene_name": "Zscan10", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain-containing protein 10 isoform 1", "refseq_ac": "NP_001028597", "gene_names_uniprotkb": "Zscan10; Zfp206", "gene_names_refseq": "Zfp206; Zkscan10; Znf206; Zscan10", "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 10; Zinc finger protein 206", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 10 isoform 1; zinc finger and SCAN domain-containing protein 10; zinc finger and SCAN domains 10; zinc finger protein 206; zinc finger with KRAB and SCAN domains 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:332221)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16971461;17344211;17628018;19740739;21750661;28846095;30771488;31219806;38386308", "class_list": "", "function": "Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4., [UniProtKB, PubMed, PubMed, PubMed]; The pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes ROS-glutathione homeostasis and the DNA damage response, and recovers genomic stability. Erratum:[Nat Cell Biol. 2019 Apr;21(4):531-532. doi: 10.1038/s41556-018-0269-y. PMID: 30643186], [RefSeq, PubMed]; ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations., [RefSeq, PubMed]; Zfp206 is a regulator of embryonic stem cell differentiation that controls a set of genes expressed very early in development, most of which themselves appear to be regulators., [RefSeq, PubMed]; Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells., [RefSeq, PubMed]; Zscan10 negatively regulates osteoclast differentiation through transcription of Hp., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZP53;Q20D61;Q20D62;Q20D63", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3URR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DU09-1", "uniprot_id": "ZN652_MOUSE", "mass": 69441.0, "length": 608, "protein_name": "Zinc finger protein 652", "gene_name": "Zfp652; Znf652", "organism": "Mouse", "refseq_name": "zinc finger protein 652", "refseq_ac": "NP_963903", "gene_names_uniprotkb": "Zfp652; Znf652; Kiaa0924; Zfp652", "gene_names_refseq": "9530033F24Rik; ZNF652; Zfp652", "protein_names_uniprotkb": "Zinc finger protein 652", "protein_names_refseq": "zinc finger protein 652", "tax_id": 10090, "disease": "", "pathway": " (mmu:268469)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21750661;34428180;40997131", "class_list": "", "function": "DNA-binding transcription repressor that acts together with CBFA2T2 to repress expression of target genes, such as TCF12. Specifically binds the DNA consensus sequence 5'-CGAAAGGGTTAAT-3'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A617;Q7TNT4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5DU09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5Y5T1-1", "uniprot_id": "ZDH20_MOUSE", "mass": 43976.0, "length": 380, "protein_name": "Palmitoyltransferase ZDHHC20", "gene_name": "Zdhhc20", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC20 isoform 2", "refseq_ac": "NP_083768", "gene_names_uniprotkb": "Zdhhc20", "gene_names_refseq": "4930542A17Rik; 5033406L14Rik; B230110O18Rik; HK11; Zdhhc20", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC20; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC20; DHHC domain-containing cysteine-rich protein 20; DHHC-20; Zinc finger DHHC domain-containing protein 20", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 20; DHHC-20; DHHC-containing protein 20; acyltransferase ZDHHC20; palmitoyltransferase ZDHHC20 isoform 2; probable palmitoyltransferase ZDHHC20; zinc finger DHHC domain-containing protein 20", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:75965)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15603741;16075062;25428507;25605945;26495903;28734079;34428180", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:15603741). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains (By similarity). May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. Palmitoylates TRIM28 and thereby plays an important role in the DNA damage repair response., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDL1;Q8VCL6;Q9D3Q8", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0006974 DNA damage response;GO:0044794 host-mediated activation of viral process;GO:0018345 protein palmitoylation;GO:0019062 virion attachment to host cell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5Y5T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q65Z95-1", "uniprot_id": "YPEL2_MOUSE", "mass": 13577.0, "length": 119, "protein_name": "Protein yippee-like 2", "gene_name": "Ypel2", "organism": "Mouse", "refseq_name": "protein yippee-like 2", "refseq_ac": "NP_001005341", "gene_names_uniprotkb": "Ypel2; Ypel", "gene_names_refseq": "6430570G24; E130113K08Rik; Ypel2", "protein_names_uniprotkb": "Protein yippee-like 2", "protein_names_refseq": "ortholog of human yippee-like 2 YPEL2; protein yippee-like 2", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:77864)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15556292;21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q65Z95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FG0-1", "uniprot_id": "ZC4H2_MOUSE", "mass": 26244.0, "length": 224, "protein_name": "Zinc finger C4H2 domain-containing protein", "gene_name": "Zc4h2", "organism": "Mouse", "refseq_name": "zinc finger C4H2 domain-containing protein isoform 1", "refseq_ac": "NP_001003916", "gene_names_uniprotkb": "Zc4h2; Hca127; Kiaa1166", "gene_names_refseq": "Gm372; Zc4h2; mKIAA1166", "protein_names_uniprotkb": "Zinc finger C4H2 domain-containing protein; Hepatocellular carcinoma-associated antigen 127 homolog", "protein_names_refseq": "hepatocellular carcinoma-associated antigen 127 homolog; zinc finger C4H2 domain-containing protein isoform 1; zinc finger C4H2 domain-containing protein", "tax_id": 10090, "disease": "Wieacker-Wolff syndrome (Disease Ontology:DOID:0060815); female-restricted Wieacker-Wolff syndrome (Disease Ontology:DOID:0061015); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:245522)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23623388;28814648;30177510;31336385;32094113;32630355;39336725", "class_list": "", "function": "In mouse primary hippocampal neurons, transiently produced ZC4H2 localized to the postsynaptic compartment of excitatory synapses, and the altered protein influenced dendritic spine density., [RefSeq, PubMed]; Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus (PubMed:32094113). Involved in neuronal development and in neuromuscular junction formation. Binds Zn(2+) ion with high affinity (By similarity). The RNF220/ZC4H2 complex monoubiquitinates PHOX2A and PHOX2B to enhance their DNA-binding ability and transactivity (PubMed:32094113)., [UniProtKB, UniProtKB, PubMed]; Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell Proliferation and Promotes Neuronal Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of ZC4H2, an Arthrogryposis Multiplex Congenita Associated Gene, Promotes Osteoclastogenesis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; RNF220 interacts with, and is co-expressed with, a zinc-finger protein ZC4H2, and they cooperate to degrade Dbx1/2 and Nkx2.2. Co-expression of RNF220 and ZC4H2 further promotes the ability of Nkx6.1 to induce ectopic Chx10+ V2 interneurons. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate that ZC4H2 promotes BMP signaling and is involved in BMP regulated myogenic and osteogenic differentiation of mouse myoblast cells., [RefSeq, PubMed]; Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Publication Status: Online-Only, [RefSeq, PubMed]; ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AUU6;Q3TSJ9;Q3U274;Q504M3;Q6ZPW6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0045211 postsynaptic membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007399 nervous system development;GO:0007528 neuromuscular junction development;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021522 spinal cord motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q68FG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6KAS7-1", "uniprot_id": "ZN521_MOUSE", "mass": 147666.0, "length": 1311, "protein_name": "Zinc finger protein 521", "gene_name": "Zfp521; Znf521", "organism": "Mouse", "refseq_name": "zinc finger protein 521 isoform 1", "refseq_ac": "NP_663467", "gene_names_uniprotkb": "Zfp521; Znf521; Evi3; Zfp521", "gene_names_refseq": "B930086A16Rik; Evi3; Zfp521; Znf521", "protein_names_uniprotkb": "Zinc finger protein 521; Ecotropic viral integration site 3 protein", "protein_names_refseq": "ecotropic viral integration site 3 protein; zinc finger protein 521 isoform 1", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:225207)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12393497;15580294;21183079;21750661;30899004", "class_list": "", "function": "Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIF5;Q8BV21;Q8CIQ2;Q8VDS6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6KAS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P0X2-1", "uniprot_id": "ZN511_MOUSE", "mass": 25761.0, "length": 227, "protein_name": "Zinc finger protein 511", "gene_name": "Zfp511; Znf511", "organism": "Mouse", "refseq_name": "zinc finger protein 511 isoform 1", "refseq_ac": "NP_081477", "gene_names_uniprotkb": "Zfp511; Znf511; Zfp511", "gene_names_refseq": "2410004P19Rik; Zfp511; Znf511", "protein_names_uniprotkb": "Zinc finger protein 511", "protein_names_refseq": "zinc finger protein 511 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69752)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24129315", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P0X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6YND2-1", "uniprot_id": "ZN653_MOUSE", "mass": 67517.0, "length": 615, "protein_name": "Zinc finger protein 653", "gene_name": "Znf653", "organism": "Mouse", "refseq_name": "zinc finger protein 653 isoform 2", "refseq_ac": "NP_796292", "gene_names_uniprotkb": "Znf653; Zfp653; Zip67", "gene_names_refseq": "E430039K05Rik; Zfp653; Zip67; Znf653", "protein_names_uniprotkb": "Zinc finger protein 653; 67 kDa zinc finger protein; Zinc finger protein Zip67", "protein_names_refseq": "67 kDa zinc finger protein; zinc finger protein 653 isoform 2; zinc finger protein Zip67", "tax_id": 10090, "disease": "", "pathway": " (mmu:319601)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12920234", "class_list": "", "function": "Novel zinc-finger protein that influences gene activation through interaction with the functionally important activation function-2 domain of nuclear receptors, [RefSeq, PubMed]; Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHT8;Q8CI02", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0050682 AF-2 domain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:1900116 extracellular negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6YND2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TB7-1", "uniprot_id": "ZSWM6_MOUSE", "mass": 133109.0, "length": 1207, "protein_name": "Zinc finger SWIM domain-containing protein 6", "gene_name": "Zswim6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zswim6; Kiaa1577", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "acromelic frontonasal dysostosis (Disease Ontology:DOID:0060342)", "pathway": " (mmu:67263)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25105228;28433741;30084848;34428180", "class_list": "", "function": "involved in nervous system development, important for striatal morphology and motor regulation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PX41;Q8CAS5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0032420 stereocilium", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0021773 striatal medium spiny neuron differentiation;GO:2001222 regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80TB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W31-1", "uniprot_id": "ZN569_MOUSE", "mass": 77248.0, "length": 679, "protein_name": "Zinc finger protein 569", "gene_name": "Znf569", "organism": "Mouse", "refseq_name": "zinc finger protein 569", "refseq_ac": "NP_848471", "gene_names_uniprotkb": "Znf569; Zfp74", "gene_names_refseq": "2810054M15Rik; KRAB8; Zfp66; Zfp74; Znf569; mszf21; mszf77; zfp-74", "protein_names_uniprotkb": "Zinc finger protein 569; Mszf21; Zfp-74; Zinc finger protein 74", "protein_names_refseq": "zinc finger protein 569", "tax_id": 10090, "disease": "", "pathway": " (mmu:72723); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "31219806;9630514", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QK35;O88237", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80W31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WQ9-1", "uniprot_id": "ZBED4_MOUSE", "mass": 130402.0, "length": 1168, "protein_name": "Zinc finger BED domain-containing protein 4", "gene_name": "Zbed4", "organism": "Mouse", "refseq_name": "zinc finger BED domain-containing protein 4", "refseq_ac": "NP_852077", "gene_names_uniprotkb": "Zbed4; Kiaa0637", "gene_names_refseq": "1700009F06Rik; Zbed4", "protein_names_uniprotkb": "Zinc finger BED domain-containing protein 4", "protein_names_refseq": "zinc finger BED domain-containing protein 4; zinc finger, BED domain containing 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:223773)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19369242;21850176;22693546", "class_list": "", "function": "Structural and functional properties of Zbed4, [RefSeq, PubMed]; The patterns of spatial and temporal expression of Zbed4 in the mouse retina suggest a possible involvement of this protein in retinal morphogenesis and Muller cell function., [RefSeq, PubMed]; Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (PubMed:22693546)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPJ9;Q80TV3;Q8R329", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80WQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGG0-1", "uniprot_id": "ZNT8_MOUSE", "mass": 40223.0, "length": 367, "protein_name": "Proton-coupled zinc antiporter SLC30A8", "gene_name": "Slc30a8", "organism": "Mouse", "refseq_name": "proton-coupled zinc antiporter SLC30A8", "refseq_ac": "NP_766404", "gene_names_uniprotkb": "Slc30a8; Znt8", "gene_names_refseq": "C820002P14Rik; Slc30a8; ZnT-8; ZnT8", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A8; Solute carrier family 30 member 8; Zinc transporter 8; ZnT-8", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A8; zinc transporter 8", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:239436); (R-MMU-264876); (R-MMU-435368)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16984975;18250168;19095428;19450229;19461125;24812429;25428506;27069933;29967002;32152506;36347424;37396167", "class_list": "", "function": "Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands., [RefSeq, PubMed]; Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion., [UniProtKB, PubMed]; Slc30a8 gene deletion is accompanied by a modest impairment in insulin secretion without major alterations in glucose metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0140826 zinc:proton antiporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0032024 positive regulation of insulin secretion;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BGG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BI66-1", "uniprot_id": "ZN526_MOUSE", "mass": 73971.0, "length": 675, "protein_name": "Zinc finger protein 526", "gene_name": "Znf526", "organism": "Mouse", "refseq_name": "zinc finger protein 526", "refseq_ac": "NP_780645", "gene_names_uniprotkb": "Znf526; Kiaa1951; Zfp526", "gene_names_refseq": "D030024H03Rik; Zfp526; Znf526", "protein_names_uniprotkb": "Zinc finger protein 526", "protein_names_refseq": "zinc finger protein 526", "tax_id": 10090, "disease": "", "pathway": " (mmu:210172)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29187734;33300544", "class_list": "", "function": "Probable transcription factor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA17;Q69Z58;Q8BIH7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BI66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJH1-1", "uniprot_id": "ZC21A_MOUSE", "mass": 35152.0, "length": 324, "protein_name": "Zinc finger C2HC domain-containing protein 1A", "gene_name": "Zc2hc1a", "organism": "Mouse", "refseq_name": "zinc finger C2HC domain-containing protein 1A isoform 1", "refseq_ac": "NP_775273", "gene_names_uniprotkb": "Zc2hc1a; Fam164a", "gene_names_refseq": "3110050N22Rik; Fam164a; Zc2hc1a", "protein_names_uniprotkb": "Zinc finger C2HC domain-containing protein 1A", "protein_names_refseq": "family with sequence similarity 164, member A; protein FAM164A; zinc finger C2HC domain-containing protein 1A isoform 1; zinc finger C2HC domain-containing protein 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67306)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "26192747;32782141;32848054;34678516;35822049;40021952;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCP6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BJH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXX2-1", "uniprot_id": "ZBT49_MOUSE", "mass": 83091.0, "length": 756, "protein_name": "Zinc finger and BTB domain-containing protein 49", "gene_name": "Zbtb49", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 49 isoform 1", "refseq_ac": "NP_083438", "gene_names_uniprotkb": "Zbtb49; Zfp509; Znf509", "gene_names_refseq": "4930518A03Rik; Zbtb49; Zfp509; Znf509", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 49; Zinc finger protein 509", "protein_names_refseq": "zinc finger and BTB domain-containing protein 49 isoform 1; zinc finger and BTB domain-containing protein 49; zinc finger protein 509", "tax_id": 10090, "disease": "", "pathway": " (mmu:75079)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25245946", "class_list": "", "function": "Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CID4;Q8K2Z6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BXX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BY46-1", "uniprot_id": "ZN574_MOUSE", "mass": 99461.0, "length": 900, "protein_name": "Zinc finger protein 574", "gene_name": "Znf574", "organism": "Mouse", "refseq_name": "zinc finger protein 574", "refseq_ac": "NP_001161978", "gene_names_uniprotkb": "Znf574; Zfp574", "gene_names_refseq": "A630056B21Rik; Zfp574; Znf574", "protein_names_uniprotkb": "Zinc finger protein 574", "protein_names_refseq": "zinc finger protein 574", "tax_id": 10090, "disease": "", "pathway": " (mmu:232976)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;31219806;34428180;35820727;36210013;39047044", "class_list": "", "function": "Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice., [RefSeq, PubMed]; Part of a ribosome quality control that mediates surveillance of ribosome assembly and promotes degradation of ribosomes with assembly defects., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDE5;Q3UNU1;Q8BKB5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0042256 cytosolic ribosome assembly;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BY46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C7B8-1", "uniprot_id": "ZSWM4_MOUSE", "mass": 122445.0, "length": 1101, "protein_name": "Zinc finger SWIM domain-containing protein 4", "gene_name": "Zswim4", "organism": "Mouse", "refseq_name": "zinc finger SWIM domain-containing protein 4", "refseq_ac": "NP_766091", "gene_names_uniprotkb": "Zswim4", "gene_names_refseq": "D330002I24; E130119J17Rik; Zswim4", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 4", "protein_names_refseq": "zinc finger SWIM domain-containing protein 4; zinc finger, SWIM domain containing 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:212168)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPN9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C7B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDC7-1", "uniprot_id": "ZBTB9_MOUSE", "mass": 49536.0, "length": 459, "protein_name": "Zinc finger and BTB domain-containing protein 9", "gene_name": "Zbtb9", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 9", "refseq_ac": "NP_001005916", "gene_names_uniprotkb": "Zbtb9", "gene_names_refseq": "3930402F13Rik; Zbtb9", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 9", "protein_names_refseq": "zinc finger and BTB domain-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:474156)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3B2;Q9CYQ0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CDC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0N9-1", "uniprot_id": "ZDHC1_MOUSE", "mass": 52979.0, "length": 484, "protein_name": "Palmitoyltransferase ZDHHC1", "gene_name": "Zdhhc1", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC1 isoform 1", "refseq_ac": "NP_780369", "gene_names_uniprotkb": "Zdhhc1", "gene_names_refseq": "4432412D04Rik; DHHC-1; Zdhhc1", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC1; 2.3.1.225; Zinc finger DHHC domain-containing protein 1", "protein_names_refseq": "palmitoyltransferase ZDHHC1 isoform 1; probable palmitoyltransferase ZDHHC1; zinc finger DHHC domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70796)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10395086;23687301;25299331;35820727;39173637", "class_list": "", "function": "Also has a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:25299331). Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components (PubMed:25299331)., [UniProtKB, PubMed]; In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes., [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3 (PubMed:23687301, PubMed:39173637). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301). Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7 (PubMed:39173637)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE36;Q8BJ24", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0044546 NLRP3 inflammasome complex assembly;GO:1905668 positive regulation of protein localization to endosome;GO:0006612 protein targeting to membrane;GO:0002230 positive regulation of defense response to virus by host;GO:0032461 positive regulation of protein oligomerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R0N9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWH1-1", "uniprot_id": "ZBT8A_MOUSE", "mass": 49151.0, "length": 434, "protein_name": "Zinc finger and BTB domain-containing protein 8A", "gene_name": "Zbtb8a", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 8A", "refseq_ac": "NP_082879", "gene_names_uniprotkb": "Zbtb8a", "gene_names_refseq": "2410081M15Rik; Zbtb8a", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 8A", "protein_names_refseq": "zinc finger and BTB domain-containing protein 8A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73680)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD30", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESC7-1", "uniprot_id": "YPEL1_MOUSE", "mass": 13468.0, "length": 118, "protein_name": "Protein yippee-like 1", "gene_name": "Ypel1", "organism": "Mouse", "refseq_name": "protein yippee-like 1 isoform 1", "refseq_ac": "NP_001277976", "gene_names_uniprotkb": "Ypel1; Ypel", "gene_names_refseq": "0610009L05Rik; 1700016N17Rik; 1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1; Ppil2; Ypel1; mdgl-1", "protein_names_uniprotkb": "Protein yippee-like 1; DGL-1; Mdgl-1", "protein_names_refseq": "cardiac Abnormality/abnormal facies (CATCH22), microdeletion syndrome; protein yippee-like 1 isoform 1; protein yippee-like 1", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:106369)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11473580;19224205;21750661;21952136;25428506;30084848;30779550", "class_list": "", "function": "May play a role in epithelioid conversion of fibroblasts., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ESC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKD9-1", "uniprot_id": "ZBT32_MOUSE", "mass": 50828.0, "length": 465, "protein_name": "Zinc finger and BTB domain-containing protein 32", "gene_name": "Zbtb32", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 32", "refseq_ac": "NP_067372", "gene_names_uniprotkb": "Zbtb32; Rog; Tzfp", "gene_names_refseq": "4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp; Zbtb32", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 32; Repressor of GATA; Testis zinc finger protein", "protein_names_refseq": "GATA repressor; repressor of GATA; testis zinc finger protein; zinc finger and BTB domain-containing protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:58206)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10755619;11279021;12932361;14688323;20544958", "class_list": "", "function": "DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor (By similarity). Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells., [UniProtKB, PubMed]; ROG is a critical part of a transcription factor NF-ATc2-initiated negative feedback mechanism of T cell activation., [RefSeq, PubMed]; ROG may confer CD8 T cell-specific repression of histone hyperacetylation and activation of the IL-4 gene locus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D523", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0030097 hemopoiesis;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JKD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1D7-1", "uniprot_id": "ZSC12_MOUSE", "mass": 57492.0, "length": 501, "protein_name": "Zinc finger and SCAN domain-containing protein 12", "gene_name": "Zscan12", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain-containing protein 12", "refseq_ac": "NP_057893", "gene_names_uniprotkb": "Zscan12; Zfp96; Znf96", "gene_names_refseq": "2510038J07Rik; FPM315; Zfp96; Zscan12; mKIAA0426; zfp-96", "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 12; Zfp-96; Zinc finger protein 96", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 12; zinc finger protein 96", "tax_id": 10090, "disease": "", "pathway": " (mmu:22758)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12860387", "class_list": "", "function": "Cloning and characterization of its expression during spermatogenesis, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0D8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z1D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPY5-1", "uniprot_id": "ZN507_MOUSE", "mass": 102884.0, "length": 941, "protein_name": "Zinc finger protein 507", "gene_name": "Zfp507; Znf507", "organism": "Mouse", "refseq_name": "zinc finger protein 507", "refseq_ac": "NP_808407", "gene_names_uniprotkb": "Zfp507; Znf507; Kiaa1084; Zfp507", "gene_names_refseq": "1810022O10Rik; A230056M16Rik; Gm480; Zfp507; Znf507; mKIAA1084", "protein_names_uniprotkb": "Zinc finger protein 507", "protein_names_refseq": "zinc finger protein 507", "tax_id": 10090, "disease": "", "pathway": " (mmu:668501)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;30084848;30779550;31219806;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQU3;Q80VK1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6ZPY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54836-1", "uniprot_id": "ZMAT3_MOUSE", "mass": 32001.0, "length": 290, "protein_name": "Zinc finger matrin-type protein 3", "gene_name": "Zmat3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zmat3; Pag608; Wig1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger matrin-type protein 3; Wild-type p53-induced gene 1 protein; Zinc finger protein WIG-1; p53-activated gene 608 protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "12135743;17234339;21750661;25428506;9400996", "class_list": "", "function": "Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0006974 DNA damage response;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54836-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KZ6-1", "uniprot_id": "ZN639_MOUSE", "mass": 55678.0, "length": 485, "protein_name": "Zinc finger protein 639", "gene_name": "Zfp639; Znf639", "organism": "Mouse", "refseq_name": "zinc finger protein 639 isoform 1", "refseq_ac": "NP_001155290", "gene_names_uniprotkb": "Zfp639; Znf639; Zasc1; Zfp639", "gene_names_refseq": "6230400O18Rik; ANC-2H01; ZASC1; Zfp639; Znf639", "protein_names_uniprotkb": "Zinc finger protein 639; Zinc finger protein ZASC1", "protein_names_refseq": "zinc finger protein 639 isoform 1; zinc finger protein ZASC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67778)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16182284;17623809;21183079;21750661;23617998;34428180", "class_list": "", "function": "Binds DNA and may function as a transcriptional repressor., [UniProtKB]; ZASC1 is important for myeloid cell differentiation in the bone marrow compartment and that this cellular factor is required for efficient Moloney murine leukemia virus replication in this tissue. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9X400;Q8BWU9", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0045892 negative regulation of DNA-templated transcription;GO:0046718 symbiont entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99KZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUK6-1", "uniprot_id": "ZBT18_MOUSE", "mass": 58385.0, "length": 522, "protein_name": "Zinc finger and BTB domain-containing protein 18", "gene_name": "Zbtb18", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 18 isoform 1", "refseq_ac": "NP_001012330", "gene_names_uniprotkb": "Zbtb18; Rp58; Zfp238; Znf238", "gene_names_refseq": "RP58; Zbtb18; Zfp238; Znf238.; zfp-238", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 18; 58 kDa repressor protein; Transcriptional repressor RP58; Zfp-238; Zinc finger protein 238", "protein_names_refseq": "58 kDa repressor protein; transcriptional repressor RP58; zinc finger and BTB domain-containing protein 18 isoform 1; zinc finger and BTB domain-containing protein 18; zinc finger protein 238", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder (Disease Ontology:DOID:0060307); autosomal dominant intellectual developmental disorder 22 (Disease Ontology:DOID:0070052)", "pathway": " (mmu:30928)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10721697;17447250;19409883;20059953;21750661;30084848;34428180;36608120;36721027;38263084", "class_list": "", "function": "Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor). Publication Status: Online-Only, [RefSeq, PubMed]; The mouse model of intellectual disability by ZBTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic impairment., [RefSeq, PubMed]; These results suggest that RP58 plays a crucial role in neuronal proliferation, migration, and differentiation in the developing cerebral cortex., [RefSeq, PubMed]; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHU9;Q7TMA6;Q80YQ4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9WUK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYA6-1", "uniprot_id": "ZCHC8_MOUSE", "mass": 78026.0, "length": 709, "protein_name": "Zinc finger CCHC domain-containing protein 8", "gene_name": "Zcchc8", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 8", "refseq_ac": "NP_081770", "gene_names_uniprotkb": "Zcchc8", "gene_names_refseq": "5730565F05Rik; Zcchc8", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 8; TRAMP-like complex RNA-binding factor ZCCHC8", "protein_names_refseq": "TRAMP-like complex RNA-binding factor ZCCHC8; zinc finger CCHC domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:70650); (R-MMU-9930044)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25153642;28135057;28528544;31219806;31488579;31599954;31747613;34428180", "class_list": "", "function": "Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells., [RefSeq, PubMed]; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK71;Q8CCB7;Q91WQ1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0071013 catalytic step 2 spliceosome;GO:0031499 TRAMP complex", "go_biological_process": "GO:0006396 RNA processing;GO:0008380 RNA splicing;GO:0031124 mRNA 3'-end processing;GO:0180034 co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CYA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SU3-1", "uniprot_id": "ZAR1_MOUSE", "mass": 39986.0, "length": 361, "protein_name": "Zygote arrest protein 1", "gene_name": "Zar1", "organism": "Mouse", "refseq_name": "zygote arrest protein 1 isoform 1", "refseq_ac": "NP_777366", "gene_names_uniprotkb": "Zar1", "gene_names_refseq": "Zar1", "protein_names_uniprotkb": "Zygote arrest protein 1; Oocyte-specific maternal effect factor", "protein_names_refseq": "oocyte-specific maternal effect factor; zygote arrest protein 1 isoform 1; zygote arrest protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:317755)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12539046;12773403;21750661;31598710;36264786", "class_list": "", "function": "The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life., [RefSeq, PubMed]; mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes (PubMed:36264786). MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth (PubMed:36264786). Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (PubMed:36264786). Binds to the 3'-UTR of maternal mRNAs (PubMed:31598710). Maternal mRNAs stored in the MARDO are translationally repressed (PubMed:36264786). Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation (PubMed:12539046, PubMed:31598710, PubMed:36264786)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZK8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0140693 molecular condensate scaffold activity;GO:0140610 RNA sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0035770 ribonucleoprotein granule;GO:0043232 intracellular membraneless organelle", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0017148 negative regulation of translation;GO:0001556 oocyte maturation;GO:0140694 membraneless organelle assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80SU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJ90-1", "uniprot_id": "ZN771_MOUSE", "mass": 35767.0, "length": 317, "protein_name": "Zinc finger protein 771", "gene_name": "Zfp771; Znf771", "organism": "Mouse", "refseq_name": "zinc finger protein 771 isoform 1", "refseq_ac": "NP_796336", "gene_names_uniprotkb": "Zfp771; Znf771; Zfp771", "gene_names_refseq": "G630024C07Rik; Zfp771; Znf771", "protein_names_uniprotkb": "Zinc finger protein 771", "protein_names_refseq": "mesenchymal stem cell protein DSC43; zinc finger protein 771 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:244216)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30059200", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSX6;Q6P5I0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BJ90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2TL60-1", "uniprot_id": "ZN667_MOUSE", "mass": 70263.0, "length": 609, "protein_name": "Zinc finger protein 667", "gene_name": "Zfp667; Znf667", "organism": "Mouse", "refseq_name": "zinc finger protein 667", "refseq_ac": "NP_001020099", "gene_names_uniprotkb": "Zfp667; Znf667; Mip1; Zfp667", "gene_names_refseq": "A830025F02Rik; Mip1; ZNF667; Zfp667", "protein_names_uniprotkb": "Zinc finger protein 667; Myocardial ischemic preconditioning up-regulated protein 1", "protein_names_refseq": "myocardial ischemic preconditioning up-regulated protein 1; zinc finger protein 667", "tax_id": 10090, "disease": "", "pathway": " (mmu:384763); (R-MMU-212436)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25428506;26383633;30084848;36968220", "class_list": "", "function": "IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]; Results demonstrated that Mipu1 regulated CD36 expression and lipid uptake, and identified a functional Mipu1-response element (MRE) in the mouse CD36 promoter during oxLDL stimulation in RAW264.7 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUH6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2TL60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIF9-1", "uniprot_id": "ZN787_MOUSE", "mass": 40477.0, "length": 381, "protein_name": "Zinc finger protein 787", "gene_name": "Zfp787; Znf787", "organism": "Mouse", "refseq_name": "zinc finger protein 787 isoform a", "refseq_ac": "NP_001013030", "gene_names_uniprotkb": "Zfp787; Znf787; Zfp787", "gene_names_refseq": "2210018M03Rik; Zfp787; Znf787", "protein_names_uniprotkb": "Zinc finger protein 787", "protein_names_refseq": "zinc finger protein 787 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:67109)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20173027;21750661;30084848;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHE2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BIF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB38-1", "uniprot_id": "ZN580_MOUSE", "mass": 18837.0, "length": 172, "protein_name": "Zinc finger protein 580", "gene_name": "Zfp580; Znf580", "organism": "Mouse", "refseq_name": "zinc finger protein 580", "refseq_ac": "NP_081176", "gene_names_uniprotkb": "Zfp580; Znf580; Zfp580", "gene_names_refseq": "1500015O20Rik; Zfp580; Znf580", "protein_names_uniprotkb": "Zinc finger protein 580", "protein_names_refseq": "zinc finger protein 580", "tax_id": 10090, "disease": "", "pathway": " (mmu:68992)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DB38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M760-1", "uniprot_id": "ZRAN1_MOUSE", "mass": 80934.0, "length": 708, "protein_name": "Ubiquitin thioesterase Zranb1", "gene_name": "Zranb1", "organism": "Mouse", "refseq_name": "ubiquitin thioesterase Zranb1 isoform 1", "refseq_ac": "NP_997185", "gene_names_uniprotkb": "Zranb1; Trabid", "gene_names_refseq": "9330160G10Rik; D7Wsu87e; Gm1956; Trabid; Zranb1", "protein_names_uniprotkb": "Ubiquitin thioesterase Zranb1; 3.4.19.12; Zinc finger Ran-binding domain-containing protein 1", "protein_names_refseq": "TRAF-binding protein; ubiquitin thioesterase Zranb1 isoform 1; ubiquitin thioesterase Zranb1; zinc finger Ran-binding domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:360216); (R-MMU-195253); (R-MMU-5689896)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12838346;21750661;26808229;34428180;36087511;37237031", "class_list": "", "function": "TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation. Publication Status: Online-Only, [RefSeq, PubMed]; Trabid regulates inflammatory T cell responses via facilitation of histone modifications at the promoters of Il12 and Il23, which involved deubiqutination and stabilization of the histone demethylase Jmjd2d., [RefSeq, PubMed]; Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;2.3.2.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016477 cell migration;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7M760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2V3-1", "uniprot_id": "ZN445_MOUSE", "mass": 114774.0, "length": 986, "protein_name": "Zinc finger protein 445", "gene_name": "Zfp445; Znf445", "organism": "Mouse", "refseq_name": "zinc finger protein 445 isoform 1", "refseq_ac": "NP_775540", "gene_names_uniprotkb": "Zfp445; Znf445; Zfp445", "gene_names_refseq": "ZNF168; Zfp445; Znf445; mszf29; mszf50", "protein_names_uniprotkb": "Zinc finger protein 445", "protein_names_refseq": "zinc finger protein 445 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:235682); (R-MMU-212436)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;23291531;25428506;25605945;30084848;30602440;34428180;40885482", "class_list": "", "function": "KAP-1 may contribute to the repression of Ey and beta-major globin gene transcription through recruitment to the promoters of these two genes, mediated by the interaction of KAP-1 with either Zfp445 or MafK, respectively, [RefSeq, PubMed]; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, ZNF445 seems to be the major factor in human early embryonic imprinting maintenance (PubMed:30602440)., [UniProtKB, PubMed]; ZFP445 and ZFP57 act together, maintaining all but one imprinting control region in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4FTX7;Q8K216", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0010385 double-stranded methylated DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0044726 epigenetic programing of female pronucleus;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R2V3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCM3-1", "uniprot_id": "ZFY21_MOUSE", "mass": 26047.0, "length": 234, "protein_name": "Zinc finger FYVE domain-containing protein 21", "gene_name": "Zfyve21", "organism": "Mouse", "refseq_name": "zinc finger FYVE domain-containing protein 21 isoform 1", "refseq_ac": "NP_081028", "gene_names_uniprotkb": "Zfyve21", "gene_names_refseq": "1110013H04Rik; Zfyve21", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 21", "protein_names_refseq": "zinc finger FYVE domain-containing protein 21 isoform 1; zinc finger FYVE domain-containing protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:68520)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20439989;21750661;21768110;36943921;38797325", "class_list": "", "function": "Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells., [RefSeq, PubMed]; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression (By similarity)., [UniProtKB]; The C-terminal region is important for the ability of ZF21 to induce disassembly of FAs and cell migration, and to promote an early step of experimental metastasis to the lung, [RefSeq, PubMed]; ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KML1;Q3TBQ9;Q9D1E2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005925 focal adhesion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VCM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ANX9-1", "uniprot_id": "ZN711_MOUSE", "mass": 86415.0, "length": 761, "protein_name": "Zinc finger protein 711", "gene_name": "Zfp711; Znf711", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zfp711; Znf711; Zfp711", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 711", "protein_names_refseq": "", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 97 (Disease Ontology:DOID:0112046)", "pathway": " (mmu:245595)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C. May compete with transcription factor ARX for activation of expression of KDM5C., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0007281 germ cell development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ANX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LH4-1", "uniprot_id": "ZN672_MOUSE", "mass": 52154.0, "length": 468, "protein_name": "Zinc finger protein 672", "gene_name": "Zfp672; Znf672", "organism": "Mouse", "refseq_name": "zinc finger protein 672", "refseq_ac": "NP_001243445", "gene_names_uniprotkb": "Zfp672; Znf672; Zfp672", "gene_names_refseq": "4930488P06Rik; 4930511N19Rik; Zfp672; Znf672", "protein_names_uniprotkb": "Zinc finger protein 672", "protein_names_refseq": "zinc finger protein 672", "tax_id": 10090, "disease": "", "pathway": " (mmu:319475); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIR7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99LH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AX39-1", "uniprot_id": "ZCHC7_MOUSE", "mass": 63000.0, "length": 541, "protein_name": "Zinc finger CCHC domain-containing protein 7", "gene_name": "Zcchc7", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 7", "refseq_ac": "NP_613056", "gene_names_uniprotkb": "Zcchc7; D4Wsu132e", "gene_names_refseq": "4930572I07Rik; D4Wsu132e; Zcchc7", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 7; TRAMP-like complex RNA-binding factor ZCCHC7", "protein_names_refseq": "TRAMP-like complex RNA-binding factor ZCCHC7; zinc finger CCHC domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:319885)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZN5;Q8C915;Q9CYZ9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0031499 TRAMP complex;GO:0005634 nucleus", "go_biological_process": "GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038 TRAMP-dependent tRNA surveillance pathway;GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process;GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process;GO:0071039 nuclear polyadenylation-dependent CUT catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AX39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2R5-1", "uniprot_id": "ZN668_MOUSE", "mass": 68347.0, "length": 619, "protein_name": "Zinc finger protein 668", "gene_name": "Zfp668; Znf668", "organism": "Mouse", "refseq_name": "zinc finger protein 668", "refseq_ac": "NP_666371", "gene_names_uniprotkb": "Zfp668; Znf668; Zfp668", "gene_names_refseq": "E130018B19Rik; Zfp668; Znf668", "protein_names_uniprotkb": "Zinc finger protein 668", "protein_names_refseq": "zinc finger protein 668", "tax_id": 10090, "disease": "", "pathway": " (mmu:244219)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation. May play a role in DNA repair process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEM2;Q3U7Y5;Q8C8B7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0P5X5-1", "uniprot_id": "ZBBX_MOUSE", "mass": 80339.0, "length": 716, "protein_name": "Zinc finger B-box domain-containing protein 1", "gene_name": "Zbbx", "organism": "Mouse", "refseq_name": "zinc finger B-box domain-containing protein 1 isoform 2", "refseq_ac": "NP_001297458", "gene_names_uniprotkb": "Zbbx", "gene_names_refseq": "4931432L23; Zbbx", "protein_names_uniprotkb": "Zinc finger B-box domain-containing protein 1", "protein_names_refseq": "zinc finger B-box domain-containing protein 1 isoform 2; zinc finger B-box domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:213234)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0J2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0P5X5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0B7-1", "uniprot_id": "ZN346_MOUSE", "mass": 32698.0, "length": 294, "protein_name": "Zinc finger protein 346", "gene_name": "Zfp346; Znf346", "organism": "Mouse", "refseq_name": "zinc finger protein 346 isoform 1", "refseq_ac": "NP_036147", "gene_names_uniprotkb": "Zfp346; Znf346; Jaz; Zfp346", "gene_names_refseq": "Jaz; Zfp346; Znf346", "protein_names_uniprotkb": "Zinc finger protein 346; Just another zinc finger protein", "protein_names_refseq": "just another zinc finger protein; zinc finger protein 346 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26919)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10488071;16931621;21750661", "class_list": "", "function": "Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (By similarity) (PubMed:10488071). May bind to specific miRNA hairpins (By similarity)., [UniProtKB, UniProtKB, PubMed]; JAZ is a novel negative regulator of cell growth by positively regulating p53., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding;GO:0003723 RNA binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R0B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VM4-1", "uniprot_id": "ZN579_MOUSE", "mass": 60792.0, "length": 562, "protein_name": "Zinc finger protein 579", "gene_name": "Zfp579; Znf579", "organism": "Mouse", "refseq_name": "zinc finger protein 579", "refseq_ac": "NP_081017", "gene_names_uniprotkb": "Zfp579; Znf579; Zfp579", "gene_names_refseq": "1110003A17Rik; Zfp579; Znf579", "protein_names_uniprotkb": "Zinc finger protein 579", "protein_names_refseq": "zinc finger protein 579", "tax_id": 10090, "disease": "", "pathway": " (mmu:68490)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24129315", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80VM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1J3-1", "uniprot_id": "ZCHC9_MOUSE", "mass": 30488.0, "length": 271, "protein_name": "Zinc finger CCHC domain-containing protein 9", "gene_name": "Zcchc9", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 9", "refseq_ac": "NP_663428", "gene_names_uniprotkb": "Zcchc9", "gene_names_refseq": "1810019C21Rik; Zcchc9", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 9", "protein_names_refseq": "zinc finger CCHC domain-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:69085)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18721783;21750661;34428180", "class_list": "", "function": "May down-regulate transcription mediated by NF-kappa-B and the serum response element., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ14;Q921T6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R1J3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZL0-1", "uniprot_id": "ZN467_MOUSE", "mass": 65633.0, "length": 594, "protein_name": "Zinc finger protein 467", "gene_name": "Zfp467; Znf467", "organism": "Mouse", "refseq_name": "zinc finger protein 467 isoform a", "refseq_ac": "NP_001078884", "gene_names_uniprotkb": "Zfp467; Znf467; Ezi; MNCb-3350; Zfp467", "gene_names_refseq": "1190001I08Rik; EZI; MNCb-3350; Zfp467; Znf467", "protein_names_uniprotkb": "Zinc finger protein 467; EZI; Endothelial cell-derived zinc finger protein", "protein_names_refseq": "endothelial cell-derived zinc finger protein; zinc finger protein 467 isoform a; zinc finger protein EZI", "tax_id": 10090, "disease": "", "pathway": " (mmu:68910)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12426389;21123171;21750661;22252242;25490389;37159501", "class_list": "", "function": "EZI. EZI is a novel nuclear zinc finger protein that augments STAT3 activity by keeping it in the nucleus., [RefSeq, PubMed]; PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that Zfp467 regulates the differentiation of adipose-derived stem cells via a mechanism involving Sost-mediated inhibition of Wnt signaling, suggesting potential therapeutic targets for the treatment of osteoporosis., [RefSeq, PubMed]; Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex., [UniProtKB, PubMed, PubMed]; Zfp467 is a novel co-factor that promotes adipocyte differentiation and suppresses osteoblast differentiation, [RefSeq, PubMed]; Zfp467 play an important role in adipose derived stem cells differentiation to adipocyte and osteoblast. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJ98", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8JZL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q569E7-1", "uniprot_id": "ZN697_MOUSE", "mass": 63065.0, "length": 569, "protein_name": "Zinc finger protein 697", "gene_name": "Zfp697; Znf697", "organism": "Mouse", "refseq_name": "zinc finger protein 697 isoform 1", "refseq_ac": "NP_766451", "gene_names_uniprotkb": "Zfp697; Znf697; Zfp697", "gene_names_refseq": "9430053K19; Zfp697; Znf697", "protein_names_uniprotkb": "Zinc finger protein 697", "protein_names_refseq": "zinc finger protein 697 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:242109)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;39141348", "class_list": "", "function": "RNA-interacting protein with a high number of miRNA targets. Acts as a damage-induced regulator of muscle remodeling by mediating the interferon gamma response in muscle cells., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIP5", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0035198 miRNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0034341 response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q569E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70121-1", "uniprot_id": "ZHX1_MOUSE", "mass": 97551.0, "length": 873, "protein_name": "Zinc fingers and homeoboxes protein 1", "gene_name": "Zhx1", "organism": "Mouse", "refseq_name": "zinc fingers and homeoboxes protein 1", "refseq_ac": "NP_001035903", "gene_names_uniprotkb": "Zhx1", "gene_names_refseq": "Zhx1", "protein_names_uniprotkb": "Zinc fingers and homeoboxes protein 1", "protein_names_refseq": "zinc fingers and homeoboxes protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22770)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12527199;14741719;17056598;17242355;21183079;21750661;25428506;28528544;30084848;30779550;34428180;40021952;40885482;40997131;8713137", "class_list": "", "function": "Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ68;Q8C6T4;Q8CJG3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P70121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSH9-1", "uniprot_id": "ZN184_MOUSE", "mass": 84027.0, "length": 737, "protein_name": "Zinc finger protein 184", "gene_name": "Zfp184", "organism": "Mouse", "refseq_name": "zinc finger protein 184 isoform 1", "refseq_ac": "NP_898835", "gene_names_uniprotkb": "Zfp184", "gene_names_refseq": "4930500C15Rik; Zfp184", "protein_names_uniprotkb": "Zinc finger protein 184", "protein_names_refseq": "zinc finger protein 184 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:193452); (R-MMU-212436)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0022603 regulation of anatomical structure morphogenesis;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TSH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20662-1", "uniprot_id": "ZFY2_MOUSE", "mass": 88127.0, "length": 777, "protein_name": "Zinc finger Y-chromosomal protein 2", "gene_name": "Zfy2", "organism": "Mouse", "refseq_name": "zinc finger Y-chromosomal protein 2", "refseq_ac": "NP_033597", "gene_names_uniprotkb": "Zfy2; Zfy-2", "gene_names_refseq": "Zfy-2; Zfy2", "protein_names_uniprotkb": "Zinc finger Y-chromosomal protein 2", "protein_names_refseq": "Y-linked zinc finger protein 2; zinc finger Y-chromosomal protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22768)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2493989;35293998", "class_list": "", "function": "Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility., [RefSeq, PubMed]; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0D8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0006355 regulation of DNA-templated transcription;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20662-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24399-1", "uniprot_id": "ZN239_MOUSE", "mass": 22818.0, "length": 201, "protein_name": "Zinc finger protein 239", "gene_name": "Znf239", "organism": "Mouse", "refseq_name": "zinc finger protein 239", "refseq_ac": "NP_001001792", "gene_names_uniprotkb": "Znf239; Mok-2; Mok2; Zfp239", "gene_names_refseq": "Mok-2; Mok2; Zfp239; Znf239", "protein_names_uniprotkb": "Zinc finger protein 239; Zfp-239; Zinc finger protein MOK-2", "protein_names_refseq": "Kruppel zinc finger protein 2; zinc finger protein 239; zinc finger protein MOK-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22685)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2104662", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99J71", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24399-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08376-1", "uniprot_id": "ZBT14_MOUSE", "mass": 50899.0, "length": 449, "protein_name": "Zinc finger and BTB domain-containing protein 14", "gene_name": "Zbtb14", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 14", "refseq_ac": "NP_033573", "gene_names_uniprotkb": "Zbtb14; Zfp-5; Zfp161; Zfp5", "gene_names_refseq": "ZF5; Zbtb14; Zfp161; b2b1982Clo", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 14; ZF5; Zfp-161; Zinc finger protein 161; Zinc finger protein 5", "protein_names_refseq": "zfp-161; zinc finger and BTB domain-containing protein 14; zinc finger protein 161; zinc finger protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:22666)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31757956;8367294;9244432", "class_list": "", "function": "Transcriptional activator of the dopamine transporter (DAT), binding its promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity). Transcriptional repressor of MYC and thymidine kinase promoters., [UniProtKB, PubMed]; ZFP161 acts as a scaffolding protein to facilitate the interaction between RPA and ATR/ATRIP. ZFP161 binds to RPA and ATR/ATRIP through distinct regions and stabilizes the RPA-ATR-ATRIP complex at stalled replication forks. This function of ZFP161 is important to the ATR signaling cascade and genome stability maintenance. ZFP161 knockout mice showed a defect in ATR activation and genomic instability. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016235 aggresome", "go_biological_process": "GO:0003170 heart valve development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001822 kidney development;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08376-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U288-1", "uniprot_id": "ZN710_MOUSE", "mass": 75052.0, "length": 666, "protein_name": "Zinc finger protein 710", "gene_name": "Zfp710; Znf710", "organism": "Mouse", "refseq_name": "zinc finger protein 710 isoform a", "refseq_ac": "NP_001139471", "gene_names_uniprotkb": "Zfp710; Znf710; Zfp710", "gene_names_refseq": "5430400N05Rik; 9830165K13; Zfp710; Znf710", "protein_names_uniprotkb": "Zinc finger protein 710", "protein_names_refseq": "zinc finger protein 710 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:209225); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U341;Q3U396;Q6P9R3;Q8BJH0;Q8BTL6;Q8BZ48", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U288-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SSZ7-1", "uniprot_id": "ZNRF3_MOUSE", "mass": 98967.0, "length": 913, "protein_name": "E3 ubiquitin-protein ligase ZNRF3", "gene_name": "Znrf3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor", "refseq_ac": "NP_001074393", "gene_names_uniprotkb": "Znrf3", "gene_names_refseq": "Gm1167; Znrf3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNRF3; 2.3.2.27; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3", "protein_names_refseq": "E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor; E3 ubiquitin-protein ligase ZNRF3; RING-type E3 ubiquitin transferase ZNRF3; zinc/RING finger protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:407821); (R-MMU-4641263)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;22575959;22895187;26495903;29769720;34995498;35820727", "class_list": "", "function": "Data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3 Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959, PubMed:22895187). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RXA5;Q3V095", "ec_number_list": "2.3.2.27", "go_molecular_function": "GO:0005109 frizzled binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5SSZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5Y5T2-1", "uniprot_id": "ZDH18_MOUSE", "mass": 41148.0, "length": 380, "protein_name": "Palmitoyltransferase ZDHHC18", "gene_name": "Zdhhc18", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC18", "refseq_ac": "NP_001017968", "gene_names_uniprotkb": "Zdhhc18", "gene_names_refseq": "DHHC-18; Zdhhc18", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC18; 2.3.1.225; DHHC domain-containing cysteine-rich protein 18; DHHC-18; Zinc finger DHHC domain-containing protein 18", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 18; palmitoyltransferase ZDHHC18; zinc finger DHHC domain-containing protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:503610)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15603741;19144319;31219806;34428180;35438208", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:15603741, PubMed:35438208). Palmitoylates HRAS and LCK (PubMed:15603741). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9F0", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0006612 protein targeting to membrane;GO:0008104 intracellular protein localization;GO:0045824 negative regulation of innate immune response;GO:0018230 peptidyl-L-cysteine S-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5Y5T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62521-1", "uniprot_id": "ZIC3_MOUSE", "mass": 50446.0, "length": 466, "protein_name": "Zinc finger protein ZIC 3", "gene_name": "Zic3", "organism": "Mouse", "refseq_name": "zinc finger protein ZIC 3", "refseq_ac": "NP_033601", "gene_names_uniprotkb": "Zic3", "gene_names_refseq": "Bn; Ka; Zic3", "protein_names_uniprotkb": "Zinc finger protein ZIC 3; Zinc finger protein of the cerebellum 3", "protein_names_refseq": "Zic family member 3 (odd-paired homolog, Drosophila); zinc finger protein ZIC 3", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 1 (Disease Ontology:DOID:0051016); right atrial isomerism (Disease Ontology:DOID:0060856); spina bifida (Disease Ontology:DOID:0080016); X-linked VACTERL association (Disease Ontology:DOID:0111766); Goldenhar syndrome (Disease Ontology:DOID:2907); holoprosencephaly (Disease Ontology:DOID:4621); visceral heterotaxy 5 (Disease Ontology:DOID:758)", "pathway": " (mmu:22773)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11053430;11238441;11959836;15207726;21750661;21858219;36852467;38091851;8557628", "class_list": "", "function": "Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'., [UniProtKB, PubMed, PubMed, PubMed]; Zic family member 3 attenuates oxidative stress-induced vascular smooth muscle cell apoptosis in patients with chronic kidney disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AWK3;Q3UYV1;Q8BSB3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0060972 left/right pattern formation;GO:1904888 cranial skeletal system development;GO:0098727 maintenance of cell number;GO:0007507 heart development;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62521-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZP1-1", "uniprot_id": "ZRAB3_MOUSE", "mass": 120896.0, "length": 1069, "protein_name": "DNA annealing helicase and endonuclease ZRANB3", "gene_name": "Zranb3", "organism": "Mouse", "refseq_name": "DNA annealing helicase and endonuclease ZRANB3 isoform 2", "refseq_ac": "NP_001272874", "gene_names_uniprotkb": "Zranb3", "gene_names_refseq": "4933425L19Rik; AH2; C730006D09; Zranb3", "protein_names_uniprotkb": "DNA annealing helicase and endonuclease ZRANB3; AH2; Annealing helicase 2; Zinc finger Ran-binding domain-containing protein 3", "protein_names_refseq": "DNA annealing helicase and endonuclease ZRANB3 isoform 2; DNA annealing helicase and endonuclease ZRANB3; annealing helicase 2; zinc finger Ran-binding domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:226409)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148X9;Q8BJJ3;Q8BWT6", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0004520 DNA endonuclease activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0031297 replication fork processing;GO:0071932 replication fork reversal", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NZP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZQ6-1", "uniprot_id": "ZN740_MOUSE", "mass": 20892.0, "length": 180, "protein_name": "Zinc finger protein 740", "gene_name": "Zfp740; Znf740", "organism": "Mouse", "refseq_name": "zinc finger protein 740 isoform 2", "refseq_ac": "NP_001276620", "gene_names_uniprotkb": "Zfp740; Znf740; Zfp740", "gene_names_refseq": "1110034O07Rik; Zfp740; Znf740", "protein_names_uniprotkb": "Zinc finger protein 740", "protein_names_refseq": "zinc finger protein 740 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68744); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19144319;21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMS3;Q8JZR3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NZQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNU6-1", "uniprot_id": "ZN250_MOUSE", "mass": 59873.0, "length": 535, "protein_name": "Zinc finger protein 250", "gene_name": "Zfp647; Znf250", "organism": "Mouse", "refseq_name": "zinc finger protein 250", "refseq_ac": "NP_001161748", "gene_names_uniprotkb": "Zfp647; Znf250; Zfp647; Znf647", "gene_names_refseq": "6030449J21; Es492; Zfp647; Znf250", "protein_names_uniprotkb": "Zinc finger protein 250; Zinc finger protein 647", "protein_names_refseq": "KRAB zinc-finger protein; zinc finger protein 250", "tax_id": 10090, "disease": "", "pathway": " (mmu:239546); (R-MMU-212436)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;31219806", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ57", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TNU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X44-1", "uniprot_id": "ZBT24_MOUSE", "mass": 78751.0, "length": 710, "protein_name": "Zinc finger and BTB domain-containing protein 24", "gene_name": "Zbtb24", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 24 isoform 2", "refseq_ac": "NP_001264158", "gene_names_uniprotkb": "Zbtb24; Bif1; Bsg1; Znf450", "gene_names_refseq": "Bif1; Bsg1; ZNF450; Zbtb24", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 24; Bone morphogenetic protein-induced factor 1; Brain-specific protein 1; Zinc finger protein 450", "protein_names_refseq": "BMP-induced factor 1; bone morphogenetic protein-induced factor 1; brain specific protein 1; zinc finger and BTB domain-containing protein 24 isoform 2; zinc finger and BTB domain-containing protein 24; zinc finger protein 450", "tax_id": 10090, "disease": "immunodeficiency-centromeric instability-facial anomalies syndrome (Disease Ontology:DOID:0090007); immunodeficiency-centromeric instability-facial anomalies syndrome 2 (Disease Ontology:DOID:0090009)", "pathway": " (mmu:268294)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15526281;21596365;27466202;31219806;34428180;36210013;37990035;39277732", "class_list": "", "function": "Consistent induction of ZNF450 by BMP-2 after 4 h in three murine pluripotent cell lines suggests that ZNF450 may play a role in the BMP-2 signalling pathway, [RefSeq, PubMed]; Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24. Erratum:[Cell Mol Immunol. 2024 Jan;21(1):100. doi: 10.1038/s41423-023-01114-w. PMID: 38114748], [RefSeq, PubMed]; May be involved in BMP2-induced transcription., [UniProtKB]; Mutation of human Zbtb24 causes ICF syndrome, [RefSeq, PubMed]; The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein containing eight C2H2-type zinc fingers and a BTB domain. Expression of this gene is induced by bone morphogenetic protein-2 signaling. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies syndrome-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]; Transcriptome analysis identified Cdca7 as the top down-regulated gene in Zbtb24 homozygous mutant mESCs, which can be restored by ectopic ZBTB24 expression. Finally, we show that this regulation is conserved between species and that CDCA7 levels are reduced in patients carrying ZBTB24 nonsense mutations, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIB7;Q7TPC4;Q8CJC9", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80X44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YR4-1", "uniprot_id": "ZN598_MOUSE", "mass": 99192.0, "length": 908, "protein_name": "E3 ubiquitin-protein ligase ZNF598", "gene_name": "Znf598", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase ZNF598 isoform 2", "refseq_ac": "NP_001335160", "gene_names_uniprotkb": "Znf598; Zfp598", "gene_names_refseq": "Ntrap; Zfp598; Znf598", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNF598; 2.3.2.27; Zinc finger protein 598", "protein_names_refseq": "E3 ubiquitin-protein ligase ZNF598 isoform 2; E3 ubiquitin-protein ligase ZNF598", "tax_id": 10090, "disease": "", "pathway": " (mmu:213753); (R-MMU-9954716)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "19864463;21183079;22517741;22645316;25153642;25428506;28528544;30059200;31219806;32782141;32848054;34428180;35822049;36852467;40021952;40885482;40997131", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains. ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs. Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation. Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10. Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides. E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3. Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs. Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression., [UniProtKB, UniProtKB]; NTRAP regulates retrograde neurotrophic signaling by controlling the formation of signaling endosomes., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAT0;Q8R3S1", "ec_number_list": "2.3.2.24;2.3.2.23;4.2.99.18;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006417 regulation of translation;GO:0016567 protein ubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q80YR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YY7-1", "uniprot_id": "ZN618_MOUSE", "mass": 104866.0, "length": 953, "protein_name": "Zinc finger protein 618", "gene_name": "Zfp618; Znf618", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zfp618; Znf618; Kiaa1952; Zfp618", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 618", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z57;Q80YY8;Q9CZ99", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001221 transcription coregulator binding;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80YY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810A1-1", "uniprot_id": "ZNF18_MOUSE", "mass": 62929.0, "length": 556, "protein_name": "Zinc finger protein 18", "gene_name": "Znf18", "organism": "Mouse", "refseq_name": "zinc finger protein 18 isoform 1", "refseq_ac": "NP_001289303", "gene_names_uniprotkb": "Znf18; Zfp535; Zkscan6", "gene_names_refseq": "1700128E15Rik; D11Ertd714e; KOX11; Zfp535; Zkscan6; Znf18", "protein_names_uniprotkb": "Zinc finger protein 18; Zinc finger protein 535; Zinc finger protein with KRAB and SCAN domains 6", "protein_names_refseq": "zinc finger protein 18 isoform 1; zinc finger protein 18; zinc finger protein 535; zinc finger protein with KRAB and SCAN domains 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:52712); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30059200;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D972", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q810A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810M5-1", "uniprot_id": "ZDH19_MOUSE", "mass": 39009.0, "length": 347, "protein_name": "Palmitoyltransferase ZDHHC19", "gene_name": "Zdhhc19", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC19", "refseq_ac": "NP_955013", "gene_names_uniprotkb": "Zdhhc19; Gm616", "gene_names_refseq": "Gm1744; Gm616; Zdhhc19", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC19; 2.3.1.225; DHHC-19; Zinc finger DHHC domain-containing protein 19", "protein_names_refseq": "DHHC-19; palmitoyltransferase ZDHHC19; probable palmitoyltransferase ZDHHC19; zinc finger DHHC domain-containing protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:245308)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34445597;34897408;40030029", "class_list": "", "function": "Palmitoyltransferase that mediates palmitoylation of proteins, such as RRAS and SQSTM1. Catalyzes palmitoylation of RRAS, leading to increased cell viability. Acts as a positive regulator of autophagy by mediating palmitoylation of SQSTM1, promoting affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Palmitoyltransferase activity is crucial for spermatogenesis (PubMed:40030029)., [UniProtKB, UniProtKB, PubMed]; ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesisdagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0035973 aggrephagy;GO:0071211 protein targeting to vacuole involved in autophagy;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:1905337 positive regulation of aggrephagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q810M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGJ0-1", "uniprot_id": "ZDH15_MOUSE", "mass": 39269.0, "length": 337, "protein_name": "Palmitoyltransferase ZDHHC15", "gene_name": "Zdhhc15", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC15", "refseq_ac": "NP_780567", "gene_names_uniprotkb": "Zdhhc15", "gene_names_refseq": "6030457O13Rik; Zdhhc15", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC15; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC15; DHHC-15; Zinc finger DHHC domain-containing protein 15", "protein_names_refseq": "DHHC-15; acyltransferase ZDHHC15; palmitoyltransferase ZDHHC15; zinc finger DHHC domain-containing protein 15", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:108672)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15603741;17012030;18596047;28167757;33788965", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:15603741, PubMed:17012030, PubMed:28167757). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (By similarity). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (By similarity). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (PubMed:15603741). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (PubMed:15603741, PubMed:17012030). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (PubMed:18596047). Could also palmitoylate FYN as shown in vitro (By similarity). May palmitoylate CALHM3 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV63;Q8BMB7", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0045184 establishment of protein localization;GO:0072657 protein localization to membrane;GO:0061001 regulation of dendritic spine morphogenesis;GO:1900006 positive regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGS3-1", "uniprot_id": "ZKSC1_MOUSE", "mass": 63439.0, "length": 561, "protein_name": "Zinc finger protein with KRAB and SCAN domains 1", "gene_name": "Zkscan1", "organism": "Mouse", "refseq_name": "zinc finger protein with KRAB and SCAN domains 1 isoform 2", "refseq_ac": "NP_084145", "gene_names_uniprotkb": "Zkscan1", "gene_names_refseq": "5930429A01Rik; 9130423L19Rik; 9230118B16Rik; KOX18; PHZ-37; ZNF139; Zkscan1", "protein_names_uniprotkb": "Zinc finger protein with KRAB and SCAN domains 1", "protein_names_refseq": "zinc finger protein 36 (KOX 18); zinc finger protein with KRAB and SCAN domains 1 isoform 2; zinc finger protein with KRAB and SCAN domains 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74570); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "31219806;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TS88;Q8BJ55;Q9CRN6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIQ3-1", "uniprot_id": "ZNF2_MOUSE", "mass": 48640.0, "length": 427, "protein_name": "Zinc finger protein 2", "gene_name": "Znf2", "organism": "Mouse", "refseq_name": "zinc finger protein 2 isoform a", "refseq_ac": "NP_001104499", "gene_names_uniprotkb": "Znf2; 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2900082I05Rik; Zmat2", "protein_names_uniprotkb": "Zinc finger matrin-type protein 2", "protein_names_refseq": "zinc finger matrin-type protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66492); (R-MMU-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBK0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CPW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQK1-1", "uniprot_id": "ZNHI3_MOUSE", "mass": 17068.0, "length": 151, "protein_name": "Zinc finger HIT domain-containing protein 3", "gene_name": "Znhit3", "organism": "Mouse", "refseq_name": "zinc finger HIT domain-containing protein 3 isoform 1", "refseq_ac": "NP_001005223", "gene_names_uniprotkb": "Znhit3; Trip3", "gene_names_refseq": "Myohd1; TRIP-3; Trip3; Znhit3", "protein_names_uniprotkb": "Zinc finger HIT domain-containing protein 3; TR-interacting protein 3; TRIP-3; Thyroid hormone receptor interactor 3; Thyroid receptor-interacting protein 3", "protein_names_refseq": "TR-interacting protein 3; myosin head domain containing 1; thyroid hormone receptor interactor 3; thyroid receptor-interacting protein 3; zinc finger HIT domain-containing protein 3 isoform 1; zinc finger HIT domain-containing protein 3", "tax_id": 10090, "disease": "PEHO syndrome (Disease Ontology:DOID:0080539)", "pathway": " (mmu:448850)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;28335020", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070761 pre-snoRNP complex", "go_biological_process": "GO:0000492 box C/D snoRNP assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQR5-1", "uniprot_id": "ZMAT5_MOUSE", "mass": 19886.0, "length": 170, "protein_name": "Zinc finger matrin-type protein 5", "gene_name": "Zmat5", "organism": "Mouse", "refseq_name": "zinc finger matrin-type protein 5 isoform 1", "refseq_ac": "NP_080291", "gene_names_uniprotkb": "Zmat5; D11Bwg1548e", "gene_names_refseq": "2610510L01Rik; D11Bwg0572e; D11Bwg1548e; Zmat5", "protein_names_uniprotkb": "Zinc finger matrin-type protein 5; U11/U12 small nuclear ribonucleoprotein 20 kDa protein; U11/U12 snRNP 20 kDa protein", "protein_names_refseq": "U11/U12 small nuclear ribonucleoprotein 20 kDa protein; U11/U12 snRNP 20 kDa protein; zinc finger matrin-type protein 5 isoform 1; zinc finger matrin-type protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67178); (R-MMU-72165)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex;GO:0071016 U12-type precatalytic spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ96-1", "uniprot_id": "ZCRB1_MOUSE", "mass": 24583.0, "length": 217, "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "Zcrb1", "organism": "Mouse", "refseq_name": "zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 2", "refseq_ac": "NP_001334026", "gene_names_uniprotkb": "Zcrb1", "gene_names_refseq": "2700088M22Rik; Madp-1; Zcrb1", "protein_names_uniprotkb": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1; MADP-1; U11/U12 small nuclear ribonucleoprotein 31 kDa protein; U11/U12 snRNP 31 kDa protein", "protein_names_refseq": "U11/U12 small nuclear ribonucleoprotein 31 kDa protein; U11/U12 snRNP 31 kDa protein; zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 2; zinc finger CCHC-type and RNA-binding motif-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67197); (R-MMU-72165)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16959469;21183079;21750661;29617656;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDL3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CZ96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0B1-1", "uniprot_id": "ZN524_MOUSE", "mass": 34809.0, "length": 321, "protein_name": "Zinc finger protein 524", "gene_name": "Znf524", "organism": "Mouse", "refseq_name": "zinc finger protein 524", "refseq_ac": "NP_079600", "gene_names_uniprotkb": "Znf524; Zfp524", "gene_names_refseq": "0610012F07Rik; 2300009P13Rik; Zfp524; Znf524", "protein_names_uniprotkb": "Zinc finger protein 524", "protein_names_refseq": "zinc finger protein 524", "tax_id": 10090, "disease": "", "pathway": " (mmu:66056)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCQ0", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D0B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB42-1", "uniprot_id": "ZN593_MOUSE", "mass": 15147.0, "length": 134, "protein_name": "Zinc finger protein 593", "gene_name": "Znf593", "organism": "Mouse", "refseq_name": "zinc finger protein 593", "refseq_ac": "NP_077177", "gene_names_uniprotkb": "Znf593; Zfp593", "gene_names_refseq": "3110024A21Rik; E130106C14Rik; ZNF593; Zfp593", "protein_names_uniprotkb": "Zinc finger protein 593; Zinc finger protein T86", "protein_names_refseq": "zinc finger protein 593; zinc finger protein T86", "tax_id": 10090, "disease": "", "pathway": " (mmu:68040)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;31442450", "class_list": "", "function": "Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity., [UniProtKB, UniProtKB]; Zfp593 overexpression in cultured muscle cells resulted in significant repression of muscle cell differentiation and attenuation of ERK1/2 and p38 phosphorylation, but did not vitiate protein synthesis. The discovery that Zfp593 is expressed in skeletal muscle combined with the observation that it is induced in response to neurogenic atrophy furthers our understanding of the molecular genetic events of muscle wasting., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZX2;Q99J54", "ec_number_list": "", "go_molecular_function": "GO:1990275 preribosome binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DB42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY24-1", "uniprot_id": "ZBP1_MOUSE", "mass": 44331.0, "length": 411, "protein_name": "Z-DNA-binding protein 1", "gene_name": "Zbp1", "organism": "Mouse", "refseq_name": "Z-DNA-binding protein 1 isoform 2", "refseq_ac": "NP_001132991", "gene_names_uniprotkb": "Zbp1; Dlm1", "gene_names_refseq": "2010010H03Rik; Dai; Dlm1; Zbp1; mZaDLM", "protein_names_uniprotkb": "Z-DNA-binding protein 1; DAI; DNA-dependent activator of IFN-regulatory factors; Tumor stroma and activated macrophage protein DLM-1", "protein_names_refseq": "DNA-dependent activator of IFN-regulatory factors; Z-DNA-binding protein 1 isoform 2; tumor stroma and activated macrophage protein DLM-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58203)", "pathway_count": 1, "publication_count": 38, "publication_id_list": "10564822;11524677;17618271;18375758;19144319;19590578;21750661;22423968;22645316;23283962;24788674;27746097;27819681;27819682;27917412;28607035;28634194;28716805;29073079;29236673;29321274;30050136;30084848;30498077;30635240;31219806;31358656;31600504;31630209;32200799;32296175;32298652;32315377;32350114;33109609;33397971;34428180;34471287", "class_list": "", "function": "Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:17618271, PubMed:18375758, PubMed:19590578, PubMed:23283962, PubMed:27746097, PubMed:27819681, PubMed:27917412, PubMed:28607035, PubMed:28716805, PubMed:29073079, PubMed:30050136, PubMed:30498077, PubMed:31358656, PubMed:32200799, PubMed:32296175). ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, caspase-8 (CASP8), and the NLRP3 inflammasome (PubMed:27746097, PubMed:27917412, PubMed:28607035, PubMed:32200799, PubMed:32296175, PubMed:32298652, PubMed:32350114). Key activator of necroptosis, a programmed cell death process in response to death-inducing TNF family members, via its ability to bind Z-RNA: once activated upon Z-RNA-binding, ZBP1 interacts and stimulates RIPK3 kinase, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (PubMed:22423968, PubMed:27746097, PubMed:27819681, PubMed:27819682, PubMed:28716805, PubMed:32200799, PubMed:32296175, PubMed:32315377, PubMed:32350114). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799, PubMed:32296175). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (PubMed:31630209). In addition to its direct role in driving necroptosis via its ability to sense Z-RNAs, also involved in PANoptosis triggered in response to bacterial infection: component of the AIM2 PANoptosome complex, a multiprotein complex that triggers PANoptosis (PubMed:34471287). Also acts as the apical sensor of fungal infection responsible for activating PANoptosis (PubMed:33109609). Involved in CASP8-mediated cell death via its interaction with RIPK1 but independently of its ability to sense Z-RNAs (PubMed:33397971). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (PubMed:30635240). In response to flavivirus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (PubMed:30635240). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mechanism of DAI activation and the complex regulatory mechanisms underlying DNA-mediated protective and pathologic immune responses., [RefSeq, PubMed]; Observations underscore an integral role of DAI (DLM-1/ZBP1) in the DNA-mediated activation of innate immune responses, [RefSeq, PubMed]; Shares common structure-specific recognition core within the binding domain with an RNA editing enzyme but binds Z-DNA, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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Gm7102; Mplkipl1", "protein_names_uniprotkb": "M-phase specific PLK1 intereacting protein like 1", "protein_names_refseq": "TTD non-photosensitive 1 protein homolog; TTD non-photosensitive 1-like protein", "tax_id": 10090, "disease": "nonphotosensitive trichothiodystrophy 4 (Disease Ontology:DOID:0050528)", "pathway": " (mmu:633057)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030496 midbody", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QQ10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NCJ0-1", "uniprot_id": "Q5NCJ0_MOUSE", "mass": 179228.0, "length": 1601, "protein_name": "Rap guanine nucleotide exchange factor (GEF) 6", "gene_name": "Rapgef6", "organism": "Mouse", "refseq_name": "rap guanine nucleotide exchange factor 6 isoform 2", "refseq_ac": "NP_780467", "gene_names_uniprotkb": "Rapgef6", "gene_names_refseq": "A530068K01; C030018K18Rik; PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2; Rapgef6; mKIAA4052", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor (GEF) 6", "protein_names_refseq": "PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain containing guanine nucleotide exchange factor(GEF)1; rap guanine nucleotide exchange factor 2; rap guanine nucleotide exchange factor 6 isoform 2", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17538012;21750661;24491570;26057047;27390776;29747665;32600317", "class_list": "", "function": "Data indicate that the testes of RA-GEF-2(-)knockout male mice were significantly smaller than those of wild-type mice and were markedly atrophied as well as hypospermatogenic., [RefSeq, PubMed]; Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking. Publication Status: Online-Only, [RefSeq, PubMed]; Rapgef2-conditional knockout (cKO) mice and Rapgef6-KO mice exhibited hyperlocomotion phenotype and working-memory defect, both of which could be recognized as schizophrenia-like behavior. Publication Status: Online-Only, [RefSeq, PubMed]; Rapgef6 deletion mice were impaired in hippocampal and amygdalar function and had reduced spine density and primary dendrite number in pyramidal neurons of the CA3 hippocampal region. Publication Status: Online-Only, [RefSeq, PubMed]; Study show that double knockout of Rapgef6 in Rapgef2-cKO mice (Rapgef2/6-dKO) results in marked enlargement of the ectopic cortical mass. While Rapgef2-cKO affects late-born neurons only, Rapgef2/6-dKO affects both early-born and late-born neurons in the developing brain. 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Publication Status: Online-Only, [RefSeq, PubMed]; The RasGAP gene, RASAL2, is a tumor and metastasis suppressor, [RefSeq, PubMed]; The down-regulation of RASAL2 promotes metastatic progression of lung adenocarcinoma, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0036477 somatodendritic compartment", "go_biological_process": "GO:1902531 regulation of intracellular signal transduction;GO:0060612 adipose tissue development;GO:0035264 multicellular organism growth;GO:0009749 response to glucose;GO:0002021 response to dietary excess", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E9PW37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PVW2-1", "uniprot_id": "E9PVW2_MOUSE", "mass": 36648.0, "length": 323, "protein_name": "Olfactory receptor", "gene_name": "Or7e176", "organism": "Mouse", "refseq_name": "olfactory receptor 872", "refseq_ac": "NP_666771", "gene_names_uniprotkb": "Or7e176; Olfr872", "gene_names_refseq": "MOR145-3; Olfr872; Or7e176", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-13999915-14000844; olfactory receptor 872; olfactory receptor MOR145-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258553)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9PVW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PX39-1", "uniprot_id": "E9PX39_MOUSE", "mass": 133956.0, "length": 1209, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif 14", "gene_name": "Adamts14", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adamts14", "gene_names_refseq": "", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif 14", "protein_names_refseq": "", "tax_id": 10090, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (R-MMU-1650814); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PX39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PYD7-1", "uniprot_id": "E9PYD7_MOUSE", "mass": 61348.0, "length": 549, "protein_name": "Kelch repeat and BTB (POZ) domain containing 6", "gene_name": "Kbtbd6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kbtbd6; Gm5465; Zbtbd6", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch repeat and BTB (POZ) domain containing 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:432879)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0035020 regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PYD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q1C1-1", "uniprot_id": "E9Q1C1_MOUSE", "mass": 97195.0, "length": 853, "protein_name": "Vomeronasal 2, receptor 118", "gene_name": "Vmn2r118", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vmn2r118", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal 2, receptor 118", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:383258)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q1C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q1Y9-1", "uniprot_id": "E9Q1Y9_MOUSE", "mass": 52810.0, "length": 479, "protein_name": "Keratin 83", "gene_name": "Krt83", "organism": "Mouse", "refseq_name": "type II hair keratin", "refseq_ac": "NP_001188252", "gene_names_uniprotkb": "Krt83; 5430421N21Rik", "gene_names_refseq": "5430421N21Rik; Krt83", "protein_names_uniprotkb": "Keratin 83", "protein_names_refseq": "keratin type II; type II hair keratin", "tax_id": 10090, "disease": "monilethrix 3 (Disease Ontology:DOID:0061153); erythrokeratodermia variabilis et progressiva 5 (Disease Ontology:DOID:0080251)", "pathway": " (mmu:100126226); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q1Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q368-1", "uniprot_id": "TARB1_MOUSE", "mass": 175691.0, "length": 1579, "protein_name": "tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1", "gene_name": "Tarbp1", "organism": "Mouse", "refseq_name": "tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1", "refseq_ac": "NP_001153379", "gene_names_uniprotkb": "Tarbp1", "gene_names_refseq": "Gm17296; Gm179; Tarbp1", "protein_names_uniprotkb": "tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1; 2.1.1.34; TAR RNA-binding protein 1", "protein_names_refseq": "TAR (HIV-1) RNA binding protein 1; probable methyltransferase TARBP1; tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212728)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19422693;25605945;30059200", "class_list": "", "function": "Binding of Dicer to TRBPs is critical for RNAi function. Publication Status: Online-Only, [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.34", "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0003723 RNA binding;GO:0141100 tRNA (guanine(18)-2'-O)-methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9Q368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F6VS78-1", "uniprot_id": "F6VS78_MOUSE", "mass": 35170.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or6c204", "organism": "Mouse", "refseq_name": "olfactory receptor 773", "refseq_ac": "NP_996891", "gene_names_uniprotkb": "Or6c204; Olfr772; Olfr773", "gene_names_refseq": "GA_x6K02T2PULF-10872859-10871923; MOR114-15; Olfr773-ps1; Olfr773; Or6c204", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 773, pseudogene 1; olfactory receptor 773", "tax_id": 10090, "disease": "", "pathway": " (mmu:257664)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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9630005K15; Dbx2; Gm1229", "protein_names_uniprotkb": "Homeobox protein DBX2; Developing brain homeobox protein 2", "protein_names_refseq": "homeobox protein DBX2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223843)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37605090", "class_list": "", "function": "Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0061351 neural precursor cell proliferation;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F8VQH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3UXL2-1", "uniprot_id": "G3UXL2_MOUSE", "mass": 34824.0, "length": 318, "protein_name": "Ribose-phosphate pyrophosphokinase 1", "gene_name": "Prps1l3", "organism": "Mouse", "refseq_name": "ribose-phosphate pyrophosphokinase", "refseq_ac": "NP_001032835", "gene_names_uniprotkb": "Prps1l3", "gene_names_refseq": "328099; AU021838; AW536152; Gm5081; Prps1l3", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 1; 2.7.6.1; Phosphoribosyl pyrophosphate synthase I", "protein_names_refseq": "ribose-phosphate pyrophosphokinase", "tax_id": 10090, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210); phosphoribosylpyrophosphate synthetase superactivity (Disease Ontology:DOID:0111260); X-linked deafness 1 (Disease Ontology:DOID:0111739); retinitis pigmentosa (Disease Ontology:DOID:10584); gout (Disease Ontology:DOID:13189)", "pathway": " (mmu:328099)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.6.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016208 AMP binding", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007399 nervous system development;GO:0006098 pentose-phosphate shunt;GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006144 purine nucleobase metabolic process;GO:0034418 urate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UXL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "J3QNQ5-1", "uniprot_id": "J3QNQ5_MOUSE", "mass": 57931.0, "length": 498, "protein_name": "BTB domain containing 35, family member 24", "gene_name": "Btbd35f24", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Btbd35f24; Gm21364", "gene_names_refseq": "", "protein_names_uniprotkb": "BTB domain containing 35, family member 24", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QNQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "L7N227-1", "uniprot_id": "L7N227_MOUSE", "mass": 34440.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r125", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 125", "refseq_ac": "NP_001160212", "gene_names_uniprotkb": "Vmn1r125", "gene_names_refseq": "EG667215; Gm8519; Vmn1r125", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r125; vomeronasal 1 receptor 125", "tax_id": 10090, "disease": "", "pathway": " (mmu:667215)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N227-1", "record_type": "protein" }, { "uniprot_canonical_ac": "L7N257-1", "uniprot_id": "L7N257_MOUSE", "mass": 10837.0, "length": 96, "protein_name": "Cystatin domain containing 6", "gene_name": "Cstdc6", "organism": "Mouse", "refseq_name": "stefin A1-like protein", "refseq_ac": "NP_001001332", "gene_names_uniprotkb": "Cstdc6; 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Wdfy4", "protein_names_uniprotkb": "WD repeat- and FYVE domain-containing protein 4", "protein_names_refseq": "WD repeat- and FYVE domain-containing protein 4 isoform X1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary autosomal dominant microcephaly 18 (Disease Ontology:DOID:0070295); Chediak-Higashi syndrome (Disease Ontology:DOID:2935)", "pathway": " (mmu:545030)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;30257884;30409884;30779550;34428180;35820727", "class_list": "", "function": "Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells (PubMed:30409884). Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking (PubMed:30409884). Also plays a role in B-cell survival through regulation of autophagy (PubMed:30257884)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0036037 CD8-positive, alpha-beta T cell activation;GO:0006914 autophagy;GO:0098586 cellular response to virus;GO:0019882 antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9Q2M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0B4J1F3-1", "uniprot_id": "A0A0B4J1F3_MOUSE", "mass": 73574.0, "length": 663, "protein_name": "Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6", "gene_name": "Lilra6", "organism": "Mouse", "refseq_name": "paired-Ig-like receptor A3 precursor", "refseq_ac": "NP_035220", "gene_names_uniprotkb": "Lilra6", "gene_names_refseq": "7M1; Lilra6; Pira3", "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6", "protein_names_refseq": "paired-Ig-like receptor A3 precursor; paired-Ig-like receptor A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:18726)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0001791 IgM binding;GO:0032396 inhibitory MHC class I receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032998 Fc-epsilon receptor I complex", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0019221 cytokine-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1B0GT13-1", "uniprot_id": "A0A1B0GT13_MOUSE", "mass": 69115.0, "length": 591, "protein_name": "Predicted gene, 17655", "gene_name": "Gm17655", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gm17655", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 17655", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GT13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A075B693-1", "uniprot_id": "A0A075B693_MOUSE", "mass": 10797.0, "length": 98, "protein_name": "Immunoglobulin heavy variable V8-4", "gene_name": "Ighv8-4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighv8-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable V8-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B693-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A075B6A9-1", "uniprot_id": "A0A075B6A9_MOUSE", "mass": 12465.0, "length": 112, "protein_name": "T cell receptor alpha variable 9D-2; T cell receptor alpha variable 9N-2", "gene_name": "Trav9d-2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Trav9d-2; Trav9n-2", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 9D-2; T cell receptor alpha variable 9N-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B6A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63038-1", "uniprot_id": "CH60_MOUSE", "mass": 60955.0, "length": 573, "protein_name": "60 kDa heat shock protein, mitochondrial", "gene_name": "Hspd1", "organism": "Mouse", "refseq_name": "60 kDa heat shock protein, mitochondrial", "refseq_ac": "NP_034607", "gene_names_uniprotkb": "Hspd1; Hsp60", "gene_names_refseq": "60kDa; CPN60; HSP-60; HSP-65; Hsp60; Hspd1", "protein_names_uniprotkb": "60 kDa heat shock protein, mitochondrial; 5.6.1.7; 60 kDa chaperonin; CPN60; Chaperonin 60; HSP-60; HSP-65; Heat shock protein 60; Hsp60; Mitochondrial matrix protein P1", "protein_names_refseq": "60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; chaperonin 60; heat shock 60kDa protein 1 (chaperonin); heat shock protein 60; heat shock protein, 60 kDa; mitochondrial matrix protein P1", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 4 (Disease Ontology:DOID:0060789); hereditary spastic paraplegia 13 (Disease Ontology:DOID:0110766); glucose intolerance (Disease Ontology:DOID:10603); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); varicocele (Disease Ontology:DOID:12337); autistic disorder (Disease Ontology:DOID:12849); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); arteriosclerosis (Disease Ontology:DOID:2349); hereditary spastic paraplegia (Disease Ontology:DOID:2476); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); aphthous stomatitis (Disease Ontology:DOID:9663)", "pathway": " (mmu:15510); (R-MMU-1268020); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 39, "publication_id_list": "10.1101/2023.09.13.557529;11801660;11908946;12734347;1347942;16075062;16393994;17242355;18642672;19009526;1979012;20887712;21183079;21750661;2263486;23576753;23806337;25605945;28011936;31219806;32152506;33300544;33725478;34105348;34260942;34428180;34887587;35820727;36064721;36288343;37453647;37507081;37828378;39927985;40684658;7523108;7875208;8093560;9574571", "class_list": "", "function": "Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 23, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P19226;P19227;P97602;Q3KQP2;Q3UIP0;Q8C2C7;Q8VEF4", "ec_number_list": "3.5.3.1;1.8.1.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.21;1.16.3.1;3.1.2.-;3.1.2.2;3.4.21.92;1.1.1.37;2.1.3.3;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;2.3.1.168;1.1.1.42;2.3.3.10;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;2.5.1.39;1.1.98.-;1.1.1.30;2.7.11.2;6.1.1.5;2.7.1.23;3.4.21.53;5.6.2.3;3.4.24.-;2.3.1.9;2.3.1.37;7.1.1.2;1.1.1.38;4.2.1.3;6.4.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;1.3.8.1;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0034185 apolipoprotein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0030135 coated vesicle;GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0032727 positive regulation of interferon-alpha production;GO:0043032 positive regulation of macrophage activation;GO:0045041 protein import into mitochondrial intermembrane space;GO:0048291 isotype switching to IgG isotypes", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P63038-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3UW50-1", "uniprot_id": "G3UW50_MOUSE", "mass": 49251.0, "length": 439, "protein_name": "Zinc finger and BTB domain-containing protein 25", "gene_name": "Zbtb25", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 25", "refseq_ac": "NP_001165575", "gene_names_uniprotkb": "Zbtb25", "gene_names_refseq": "2810462M08Rik; 2900064P18Rik; Kup; Zbtb25; Zfp-50; Zfp50", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 25", "protein_names_refseq": "zinc finger and BTB domain-containing protein 25; zinc finger protein 50", "tax_id": 10090, "disease": "", "pathway": " (mmu:109929)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UW50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBC7-1", "uniprot_id": "TRM7_MOUSE", "mass": 35586.0, "length": 324, "protein_name": "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase", "gene_name": "Ftsj1", "organism": "Mouse", "refseq_name": "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform 1", "refseq_ac": "NP_598752", "gene_names_uniprotkb": "Ftsj1", "gene_names_refseq": "Ftsj1; Ftsjl; Ftsj; Sfc12", "protein_names_uniprotkb": "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; 2'-O-ribose RNA methyltransferase TRM7 homolog; 2.1.1.205; Protein ftsJ homolog 1", "protein_names_refseq": "2'-O-ribose RNA methyltransferase TRM7 homolog; FtsJ RNA methyltransferase homolog 1; protein ftsJ homolog 1; putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform 1", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 9 (Disease Ontology:DOID:0112034)", "pathway": " (mmu:54632)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30557699;33771871;36101392", "class_list": "", "function": "Loss sof Ftsj1 gene is associated with intellectual disability., [RefSeq, PubMed]; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:33771871). Requisite for faithful cytoplasmic translation (PubMed:33771871). Requires THADA for methylation of the cytidine at position 32 of the anticodon loop of substrate tRNAs (By similarity). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (By similarity). Promotes translation efficiency of the UUU codon (PubMed:33771871). Plays a role in neurogenesis (PubMed:33771871, PubMed:36101392). Required for expression of genes involved in neurogenesis and mitochondrial translation and energy generation (PubMed:30557699, PubMed:33771871, PubMed:36101392). Requisite for RNA-mediated gene silencing (By similarity). May modify position 32 in tRNA(Arg(ACG)), tRNA(Gln(CUG)), tRNA(Leu(UAA)), tRNA(Leu(UAG)), tRNA(Leu(AAG)), tRNA(Leu(CAG)), tRNA(Phe(GAA)), tRNA(Trp(CCA)) and tRNA(Val(AAC)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Leu(UAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:33771871)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALH2;Q8JZY1;Q91XA6", "ec_number_list": "2.1.1.205", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0016423 tRNA (guanine) methyltransferase activity;GO:0106050 tRNA 2'-O-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0106339 tRNA (cytidine(32)-2'-O)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0030488 tRNA methylation;GO:0022008 neurogenesis;GO:0002181 cytoplasmic translation;GO:0002130 wobble position ribose methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CBC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2CG24-1", "uniprot_id": "A2CG24_MOUSE", "mass": 44154.0, "length": 393, "protein_name": "Testis expressed basic protein 1", "gene_name": "Tsbp1", "organism": "Mouse", "refseq_name": "testis-expressed basic protein 1 isoform 1", "refseq_ac": "NP_001001177", "gene_names_uniprotkb": "Tsbp1; BC051142", "gene_names_refseq": "NG8; TSBP; Tesbp; Tesb; Tsbp1", "protein_names_uniprotkb": "Testis expressed basic protein 1", "protein_names_refseq": "testis specific basic protein; testis-expressed basic protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:407788)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2CG24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGN9-1", "uniprot_id": "Q8VGN9_MOUSE", "mass": 35077.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or4c35", "organism": "Mouse", "refseq_name": "olfactory receptor family 4 subfamily C member 35", "refseq_ac": "NP_667192", "gene_names_uniprotkb": "Or4c35; Olfr1260", "gene_names_refseq": "MOR232-2; Olfr1260; Or4c35", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-51409740-51410672; olfactory receptor 1260; olfactory receptor MOR232-2; olfactory receptor family 4 subfamily C member 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:258983)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGI2-1", "uniprot_id": "Q8VGI2_MOUSE", "mass": 35700.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or1e1c", "organism": "Mouse", "refseq_name": "olfactory receptor 376 isoform 2", "refseq_ac": "NP_667133", "gene_names_uniprotkb": "Or1e1c; Olfr376", "gene_names_refseq": "MOR135-12; Olfr376; Or1e1c", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2P1NL-3535075-3536028; olfactory receptor 376 isoform 2; olfactory receptor 376; olfactory receptor MOR135-12", "tax_id": 10090, "disease": "", "pathway": " (mmu:258924); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0N4SUP0-1", "uniprot_id": "A0A0N4SUP0_MOUSE", "mass": 34987.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or1x6", "organism": "Mouse", "refseq_name": "olfactory receptor 1375", "refseq_ac": "NP_666727", "gene_names_uniprotkb": "Or1x6; Olfr1375", "gene_names_refseq": "MOR126-2; Olfr1375-ps1; Olfr1375; Or1x6", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2QP88-4389999-4389056; olfactory receptor 1375, pseudogene 1; olfactory receptor 1375; olfactory receptor MOR126-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258509)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0N4SUP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5RM98-1", "uniprot_id": "A0A1D5RM98_MOUSE", "mass": 10226.0, "length": 91, "protein_name": "Predicted gene 5485", "gene_name": "Gm5485", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gm5485", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 5485", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5RM98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AHM2-1", "uniprot_id": "A2AHM2_MOUSE", "mass": 34525.0, "length": 298, "protein_name": "Zinc finger protein 931", "gene_name": "Zfp931", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC353208", "refseq_ac": "NP_001156394", "gene_names_uniprotkb": "Zfp931", "gene_names_refseq": "2810021G02Rik; Zfp931", "protein_names_uniprotkb": "Zinc finger protein 931", "protein_names_refseq": "novel KRAB box and zinc finger, C2H2 type domain containing protein; uncharacterized protein LOC353208", "tax_id": 10090, "disease": "", "pathway": " (mmu:353208); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AHM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AHM8-1", "uniprot_id": "A2AHM8_MOUSE", "mass": 35457.0, "length": 319, "protein_name": "Olfactory receptor", "gene_name": "Or11q2", "organism": "Mouse", "refseq_name": "olfactory receptor family 11 subfamily Q member 2", "refseq_ac": "NP_997123", "gene_names_uniprotkb": "Or11q2; Olfr1320", "gene_names_refseq": "GA_x6K02T2Q64A-11736563-11737522; MOR122-3; Olfr1320; Or11q2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1320; olfactory receptor GA_x6K02T2Q64A-11736563-11737522; olfactory receptor family 11 subfamily Q member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:236784)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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Gm6164; Gm8653; Vmn1r251", "gene_names_refseq": "EG667472; Gm8653; Vmn1r144; Vmn1r251", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomeronasal 1 receptor Vmn1r144", "tax_id": 10090, "disease": "", "pathway": " (mmu:620574); (mmu:667472)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K9J7G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "L7MU53-1", "uniprot_id": "L7MU53_MOUSE", "mass": 34971.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or4c116", "organism": "Mouse", "refseq_name": "olfactory receptor 1221", "refseq_ac": "NP_667113", "gene_names_uniprotkb": "Or4c116; Olfr1221", "gene_names_refseq": "MOR233-3; Olfr1221; Or4c116", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-50591144-50590209; olfactory receptor 1221; olfactory receptor MOR233-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258904)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;32061665", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; This odorant receptor, Olfr1221, responds to the odorant whiskey lactone in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "L7MU53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79568-1", "uniprot_id": "P79568_MOUSE", "mass": 37407.0, "length": 326, "protein_name": "Histocompatibility 2, Q region locus 6", "gene_name": "H2-Q6", "organism": "Mouse", "refseq_name": "histocompatibility 2, Q region locus 6 isoform a precursor", "refseq_ac": "NP_997531", "gene_names_uniprotkb": "H2-Q6", "gene_names_refseq": "0610037M15Rik; H-2Q6; H2-K1; H2-Q6; Qa-6; Qa6", "protein_names_uniprotkb": "Histocompatibility 2, Q region locus 6", "protein_names_refseq": "MHC class II antigen K; histocompatibility 2, Q region locus 6 isoform a precursor; put. Q8 antigen", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); graft-versus-host disease (Disease Ontology:DOID:0081267); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); otosclerosis (Disease Ontology:DOID:12185); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:110557)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79568-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VBL3-1", "uniprot_id": "RBM15_MOUSE", "mass": 105722.0, "length": 962, "protein_name": "RNA-binding protein 15", "gene_name": "Rbm15", "organism": "Mouse", "refseq_name": "RNA-binding protein 15", "refseq_ac": "NP_001039272", "gene_names_uniprotkb": "Rbm15; Kiaa4257; Ott1", "gene_names_refseq": "C230088J01Rik; Rbm15; mKIAA1438", "protein_names_uniprotkb": "RNA-binding protein 15; One-twenty two protein 1; RNA-binding motif protein 15", "protein_names_refseq": "RNA-binding protein 15; one-twenty two protein 1; putative RNA-binding protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:229700)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17283045;17376872;18981216;25468569;26190105;29535189;31020615;36803098;37191290;38150369", "class_list": "", "function": "HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition., [RefSeq, PubMed]; Ott1 (Rbm15) has essential roles in hematopoietic, trophoblast, cardiac, and splenic development, [RefSeq, PubMed]; RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:29535189). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (By similarity). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (PubMed:17283045, PubMed:17376872, PubMed:18981216, PubMed:25468569). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (By similarity). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (PubMed:18981216). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (PubMed:25468569). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (By similarity). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (By similarity). May be implicated in HOX gene regulation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Rbm15 has pleiotropic roles in hematopoietic development., [RefSeq, PubMed]; Rbm15 is differentially expressed during hematopoiesis and may act to inhibit myeloid differentiation in hematopoietic cells via a mechanism that is mediated by stimulation of Notch signaling via RBPJkappa. GeneRIF: the N terminus of Rbm15 coimmunoprecipitates with RBPJkappa, a critical factor in Notch signaling, and the Rbm15 N terminus has a dominant negative effect, impairing activation of HES1 promoter activity by full-length-Rbm15, [RefSeq, PubMed]; Rbm15 is required for Xist-mediated silencing. Rbm15 is important for efficient deposition of H3K27me3 on the inactive chromosome., [RefSeq, PubMed]; THE ROLE OF N6-METHYLADENOSINE METHYLTRANSFERASE RBM15 IN NONALCOHOLIC FATTY LIVER DISEASE., [RefSeq, PubMed]; The regulation of BAF155 by RBM15 depends on the activity of the mRNA methylation complex core catalytic subunit METTL3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0PJG5;Q3THK4;Q3TLX0;Q571M7;Q66JP8;Q6PGG1;Q7TT82", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0048536 spleen development;GO:0045652 regulation of megakaryocyte differentiation;GO:0001569 branching involved in blood vessel morphogenesis;GO:0060412 ventricular septum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q0VBL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2MHN3-1", "uniprot_id": "ZFHX2_MOUSE", "mass": 273485.0, "length": 2562, "protein_name": "Zinc finger homeobox protein 2", "gene_name": "Zfhx2", "organism": "Mouse", "refseq_name": "zinc finger homeobox protein 2", "refseq_ac": "NP_001034287", "gene_names_uniprotkb": "Zfhx2; Kiaa1056; zfh-5", "gene_names_refseq": "ZFH-5; Zfhx2", "protein_names_uniprotkb": "Zinc finger homeobox protein 2; Zinc finger homeodomain protein 5", "protein_names_refseq": "zinc finger homeobox protein 2; zinc finger homeodomain protein 5", "tax_id": 10090, "disease": "spinocerebellar ataxia 4 (Disease Ontology:DOID:0050957); Marsili syndrome (Disease Ontology:DOID:0081075); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:239102)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16257534;23300874;29253101;34678516", "class_list": "", "function": "Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype, [RefSeq, PubMed]; Results report features of zfh-5 isolated from the mouse brain; in addition to the mRNA, the antisense strand of zfh-5 is also expressed in the developing brain, in a manner complementary to the expression of zfh-5 mRNA., [RefSeq, PubMed]; Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli., [UniProtKB, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 0, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU04;Q80VJ9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030534 adult behavior;GO:0051930 regulation of sensory perception of pain;GO:0045664 regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2MHN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SW48-1", "uniprot_id": "Q5SW48_MOUSE", "mass": 35569.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or4d1", "organism": "Mouse", "refseq_name": "olfactory receptor 464", "refseq_ac": "NP_666524", "gene_names_uniprotkb": "Or4d1; Olfr464", "gene_names_refseq": "MOR240-2; Olfr464; Or4d1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PAEV-9555122-9554181; olfactory receptor 464; olfactory receptor MOR240-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258407)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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[provided by RefSeq, Jul 2008]., [RefSeq]; Possible taste receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TS01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGV4-1", "uniprot_id": "Q8CGV4_MOUSE", "mass": 35877.0, "length": 317, "protein_name": "Retinol dehydrogenase 1 (all trans)", "gene_name": "Rdh1", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 16 precursor", "refseq_ac": "NP_536684", "gene_names_uniprotkb": "Rdh1", "gene_names_refseq": "Rdh1", "protein_names_uniprotkb": "Retinol dehydrogenase 1 (all trans)", "protein_names_refseq": "retinol dehydrogenase 1 (11-cis); 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The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A4L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ASV2-1", "uniprot_id": "A2ASV2_MOUSE", "mass": 35031.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or9g20", "organism": "Mouse", "refseq_name": "olfactory receptor 1016", "refseq_ac": "NP_001011758", "gene_names_uniprotkb": "Or9g20; Olfr1016", "gene_names_refseq": "MOR213-9; Olfr1016; Or9g20", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-47278889-47277960; olfactory receptor 1016; olfactory receptor MOR188-1; olfactory receptor MOR213-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:257915); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ASV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KGY4-1", "uniprot_id": "A3KGY4_MOUSE", "mass": 35163.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or4c119", "organism": "Mouse", "refseq_name": "olfactory receptor family 4 subfamily C member 119", "refseq_ac": "NP_001423069", "gene_names_uniprotkb": "Or4c119; Olfr1224", "gene_names_refseq": "MOR233-15; Olfr1224-ps1; Olfr1224; Or4c119", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-50635980-50635046; olfactory receptor 1224, pseudogene 1; olfactory receptor MOR233-15; olfactory receptor family 4 subfamily C member 119", "tax_id": 10090, "disease": "", "pathway": " (mmu:258026)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140T8L8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3KGY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AWN6-1", "uniprot_id": "SCN2A_MOUSE", "mass": 227945.0, "length": 2006, "protein_name": "Sodium channel protein type 2 subunit alpha", "gene_name": "Scn2a", "organism": "Mouse", "refseq_name": "sodium channel protein type 2 subunit alpha isoform 1", "refseq_ac": "NP_001092768", "gene_names_uniprotkb": "Scn2a; Scn2a1", "gene_names_refseq": "6430408L10; A230052E19Rik; Nav1.2; Scn2a1; Scn2a", "protein_names_uniprotkb": "Sodium channel protein type 2 subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2", "protein_names_refseq": "sodium channel protein type 2 subunit alpha isoform 1; sodium channel protein type 2 subunit alpha; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha polypeptide 1; voltage-gated sodium channel subunit alpha Nav1.2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); episodic ataxia type 9 (Disease Ontology:DOID:0060965); developmental and epileptic encephalopathy 11 (Disease Ontology:DOID:0080421); Dravet syndrome (Disease Ontology:DOID:0080422); benign familial infantile seizures 3 (Disease Ontology:DOID:0081116); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (mmu:110876)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10827969;11166117;21750661;28137877;29867081;33300544;40885482", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:10827969, PubMed:11166117, PubMed:28137877). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (PubMed:29867081)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 9, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "A0A0J9YTW6", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0043522 leucine zipper domain binding;GO:0005272 sodium channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0014704 intercalated disc", "go_biological_process": "GO:0007399 nervous system development;GO:0007613 memory;GO:0019228 neuronal action potential;GO:0051402 neuron apoptotic process;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "B1AWN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B9EK06-1", "uniprot_id": "EXC1L_MOUSE", "mass": 20158.0, "length": 172, "protein_name": "Exocyst complex component 1-like", "gene_name": "Exoc1l", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Exoc1l; Gm7271", "gene_names_refseq": "", "protein_names_uniprotkb": "Exocyst complex component 1-like", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B9EK06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YTY1-1", "uniprot_id": "D3YTY1_MOUSE", "mass": 34472.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r107", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 155", "refseq_ac": "NP_001160225", "gene_names_uniprotkb": "Vmn1r107; Vmn1r130; Vmn1r137; Vmn1r155; Vmn1r165", "gene_names_refseq": "EG667530; Gm8687; Vmn1r155", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r155; vomeronasal 1 receptor 155", "tax_id": 10090, "disease": "", "pathway": " (mmu:100043596); (mmu:100043614); (mmu:100043667); (mmu:667530); (mmu:673977)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YTY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q6L7-1", "uniprot_id": "E9Q6L7_MOUSE", "mass": 25506.0, "length": 222, "protein_name": "Glutathione S-transferase", "gene_name": "Gsta5", "organism": "Mouse", "refseq_name": "Glutathione S-transferase A2-like", "refseq_ac": "NP_001116132", "gene_names_uniprotkb": "Gsta5; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Kcnk6; Toss; Twik2", "protein_names_uniprotkb": "Potassium channel subfamily K member 6", "protein_names_refseq": "TWIK-2 two-pore-domain K+ channel; potassium channel subfamily K member 6", "tax_id": 10090, "disease": "brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:52150); (R-MMU-1299308); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16354767;19144319;25245387;28011936;28381826;29958799;30632293;37158595", "class_list": "", "function": "Deletion of Kcnk6 (encoding two-pore domain K(+) channel TWIK2) prevents NLR Family, Pyrin Domain-Containing 3 Protein (NLRP3) inflammasome activation in macrophages and suppressed sepsis-induced lung inflammation. Adoptive transfer of Kcnk6(-/-) macrophages into mouse airways after macrophage depletion also prevents inflammatory lung injury., [RefSeq, PubMed]; Endosomal trafficking of two-pore K[+] efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury. Publication Status: Online-Only, [RefSeq, PubMed]; K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:28381826, PubMed:29958799). Active in lysosomes where it regulates lysosome numbers and size (PubMed:28381826). In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (PubMed:29958799)., [UniProtKB, PubMed, PubMed]; Mice deficient in the TWIK-2 channel develop pulmonary hypertension between 8 and 20 weeks of age through a mechanism involving Rho-kinase., [RefSeq, PubMed]; Twik-2-/- mice have enhanced vasocontractility in the distal pulmonary vasculature., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0003085 negative regulation of systemic arterial blood pressure;GO:0003073 regulation of systemic arterial blood pressure;GO:0060075 regulation of resting membrane potential;GO:0071805 potassium ion transmembrane transport;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TBV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q504M2-1", "uniprot_id": "PDP2_MOUSE", "mass": 59947.0, "length": 532, "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial", "gene_name": "Pdp2", "organism": "Mouse", "refseq_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial", "refseq_ac": "NP_001019777", "gene_names_uniprotkb": "Pdp2", "gene_names_refseq": "4833426J09Rik; Gm1705; PDP 2; PDPC 2; Pdp2; mKIAA1348", "protein_names_uniprotkb": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; 3.1.3.43; PDP 2; PDPC 2; Pyruvate dehydrogenase phosphatase catalytic subunit 2", "protein_names_refseq": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial; pyruvate dehydrogenase phosphatase isoenzyme 2; pyruvate dehyrogenase phosphatase catalytic subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:382051); (R-MMU-204174)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21952136;30150402;30779550", "class_list": "", "function": "ICER was found to bind to the Pdp2 promoter and suppress its expression. Furthermore, forced expression of PDP2 in CD4(+) cells reduced the in vitro Th17 differentiation, whereas shRNA-based suppression of PDP2 expression increased in vitro Th17 differentiation, [RefSeq, PubMed]; Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (PubMed:30150402)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.1.4;1.2.4.1;3.1.3.43;2.3.1.12", "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042093 T-helper cell differentiation;GO:0035970 peptidyl-threonine dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q504M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SW49-1", "uniprot_id": "Q5SW49_MOUSE", "mass": 35295.0, "length": 311, "protein_name": "Olfactory receptor family 4 subfamily D member 2", "gene_name": "Or4d2", "organism": "Mouse", "refseq_name": "olfactory receptor 463", "refseq_ac": "NP_666525", "gene_names_uniprotkb": "Or4d2; Olfr462; Olfr463", "gene_names_refseq": "MOR240-1; Olfr463; Or4d2", "protein_names_uniprotkb": "Olfactory receptor family 4 subfamily D member 2", "protein_names_refseq": "GA_x6K02T2PAEV-9540823-9539888; olfactory receptor 463; olfactory receptor MOR240-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258408)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SW49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DR98-1", "uniprot_id": "NRG1_MOUSE", "mass": 71382.0, "length": 645, "protein_name": "Pro-neuregulin-1, membrane-bound isoform", "gene_name": "Nrg1", "organism": "Mouse", "refseq_name": "pro-neuregulin-1, membrane-bound isoform isoform 2", "refseq_ac": "NP_001351350", "gene_names_uniprotkb": "Nrg1", "gene_names_refseq": "6030402G23Rik; ARIA; D230005F13Rik; GGFII; GGF; HRGalpha; HRG; Hgl; NDF; Nrg1; Pro-NRG1; SMDF", "protein_names_uniprotkb": "Pro-neuregulin-1, membrane-bound isoform; ARIA; Acetylcholine receptor-inducing activity; Glial growth factor; HRG; Heregulin; Neu differentiation factor; Pro-NRG1; Sensory and motor neuron-derived factor", "protein_names_refseq": "heregulin; pro-neuregulin-1, membrane-bound isoform isoform 2; pro-neuregulin-1, membrane-bound isoform; type I neuregulin 1; type III neuregulin 1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); schizophrenia 6 (Disease Ontology:DOID:0070082); overactive bladder syndrome (Disease Ontology:DOID:0070355); amblyopia (Disease Ontology:DOID:10376); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); dementia (Disease Ontology:DOID:1307); interstitial cystitis (Disease Ontology:DOID:13949); cerebral malaria (Disease Ontology:DOID:14069); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); psychotic disorder (Disease Ontology:DOID:2468); substance abuse (Disease Ontology:DOID:302); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); schizophrenia (Disease Ontology:DOID:5419); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); neuropathy (Disease Ontology:DOID:870); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:211323); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1250342); (R-MMU-1250347); (R-MMU-1257604); (R-MMU-1306955); (R-MMU-1358803); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8863795)", "pathway_count": 16, "publication_count": 2, "publication_id_list": "19935654;21750661", "class_list": "", "function": "Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0030296 protein tyrosine kinase activator activity;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005615 extracellular space;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0046579 positive regulation of Ras protein signal transduction;GO:0021781 glial cell fate commitment;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0038127 ERBB signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DR98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M719-1", "uniprot_id": "Q7M719_MOUSE", "mass": 36230.0, "length": 310, "protein_name": "Taste receptor type 2", "gene_name": "Tas2r115", "organism": "Mouse", "refseq_name": "taste receptor, type 2, member 115", "refseq_ac": "NP_996903", "gene_names_uniprotkb": "Tas2r115", "gene_names_refseq": "T2R15; Tas2r115; Tas2r15; mGR15; mt2r49", "protein_names_uniprotkb": "Taste receptor type 2", "protein_names_refseq": "taste receptor, type 2, member 115", "tax_id": 10090, "disease": "", "pathway": " (mmu:353325)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M719-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQZ9-1", "uniprot_id": "Q7TQZ9_MOUSE", "mass": 34872.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or4c15b", "organism": "Mouse", "refseq_name": "olfactory receptor family 4 subfamily C member 15B", "refseq_ac": "NP_001011761", "gene_names_uniprotkb": "Or4c15b; Olfr1229", "gene_names_refseq": "MOR233-19; MOR233-22; Olfr1229; Or4c15b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-50727797-50726862; olfactory receptor 1229; olfactory receptor MOR233-19; olfactory receptor family 4 subfamily C member 15B", "tax_id": 10090, "disease": "", "pathway": " (mmu:257921)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGY9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TR25-1", "uniprot_id": "Q7TR25_MOUSE", "mass": 34714.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or5d40", "organism": "Mouse", "refseq_name": "olfactory receptor 1168", "refseq_ac": "NP_666742", "gene_names_uniprotkb": "Or5d40; Olfr1168", "gene_names_refseq": "MOR174-13; Olfr1168; Or5d40", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-49669483-49670421; olfactory receptor 1168; olfactory receptor MOR174-13", "tax_id": 10090, "disease": "", "pathway": " (mmu:258524)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TR25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TR94-1", "uniprot_id": "Q7TR94_MOUSE", "mass": 35134.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or9g4b", "organism": "Mouse", "refseq_name": "olfactory receptor 1015", "refseq_ac": "NP_666782", "gene_names_uniprotkb": "Or9g4b; Olfr1015", "gene_names_refseq": "MOR213-3; Olfr1015; Or9g4b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-47264151-47265089; olfactory receptor 1015; olfactory receptor MOR213-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258564)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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May play a role in outer and inner dynein arm assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CC70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDT5-1", "uniprot_id": "SMI11_MOUSE", "mass": 15505.0, "length": 131, "protein_name": "Sperm microtubule inner protein 11", "gene_name": "Spmip11", "organism": "Mouse", "refseq_name": "sperm microtubule inner protein 11", "refseq_ac": "NP_001188251", "gene_names_uniprotkb": "Spmip11; Tex49", "gene_names_refseq": "4930415O20Rik; Spmip11; Tex49", "protein_names_uniprotkb": "Sperm microtubule inner protein 11; Testis-expressed protein 49", "protein_names_refseq": "sperm microtubule inner protein 11; testis expressed 49; testis-expressed protein 49", "tax_id": 10090, "disease": "", "pathway": " (mmu:73863)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37295417", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, UniProtKB]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme (PubMed:37295417). May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (PubMed:37295417)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CDT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8HWE7-1", "uniprot_id": "MILL1_MOUSE", "mass": 44745.0, "length": 395, "protein_name": "MHC class I-like protein MILL1", "gene_name": "Mill1", "organism": "Mouse", "refseq_name": "MHC class I-like protein MILL1 precursor", "refseq_ac": "NP_715630", "gene_names_uniprotkb": "Mill1", "gene_names_refseq": "5530400I18Rik; Mill1", "protein_names_uniprotkb": "MHC class I-like protein MILL1; MHC class I-like located near the leukocyte receptor complex 1", "protein_names_refseq": "MHC class I-like located near the leukocyte receptor complex 1; MHC class I-like protein MILL1 precursor; MHC class I-like protein MILL1", "tax_id": 10090, "disease": "", "pathway": " (mmu:266815)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12370446;16920948;18560379;26902929", "class_list": "", "function": "Mill1 and Mill2 genes are predicted to encode membrane glycoproteins with domain organization essentially similar to that of MHC class I heavy chains., [RefSeq, PubMed]; Our results suggest a role for the Mill proteins in cellular metabolism, with possible therapeutic significance., [RefSeq, PubMed]; Reversal of epigenetic silencing of MICA and MICB improves immune recognition and killing of Merkel cell carcinoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; Two members of the mouse MILL family, MILL1 and MILL2, are GPI-anchored glycoproteins associated with beta2-microglobulin (beta2m), [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8HWA4;Q8HWA5", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8HWE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4D0-1", "uniprot_id": "Q8K4D0_MOUSE", "mass": 33689.0, "length": 298, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r191", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 191", "refseq_ac": "NP_665848", "gene_names_uniprotkb": "Vmn1r191", "gene_names_refseq": "V1rh15; Vmn1r191", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r191; vomeronasal 1 receptor 191; vomeronasal 1 receptor, H15; vomeronasal type 1 receptor H15", "tax_id": 10090, "disease": "", "pathway": " (mmu:632534)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R259-1", "uniprot_id": "Q8R259_MOUSE", "mass": 34423.0, "length": 302, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r202", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 202", "refseq_ac": "NP_598985", "gene_names_uniprotkb": "Vmn1r202", "gene_names_refseq": "V1ri7; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGP3-1", "uniprot_id": "Q8VGP3_MOUSE", "mass": 34001.0, "length": 304, "protein_name": "Olfactory receptor", "gene_name": "Or4b1", "organism": "Mouse", "refseq_name": "olfactory receptor 1270", "refseq_ac": "NP_667196", "gene_names_uniprotkb": "Or4b1; Olfr1270", "gene_names_refseq": "MOR227-1; Olfr1270; Or4b1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-51584440-51583526; olfactory receptor 1270; olfactory receptor MOR227-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258987)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGZ6-1", "uniprot_id": "Q8VGZ6_MOUSE", "mass": 35096.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or51f5", "organism": "Mouse", "refseq_name": "olfactory receptor family 51 subfamily F member 5", "refseq_ac": "NP_667303", "gene_names_uniprotkb": "Or51f5; Olfr561", "gene_names_refseq": "MOR14-2; Olfr561; Or51f5", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-5491151-5492095; olfactory receptor 561; olfactory receptor MOR14-2; olfactory receptor family 51 subfamily F member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:259096)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGZ9-1", "uniprot_id": "Q8VGZ9_MOUSE", "mass": 35933.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or52e7", "organism": "Mouse", "refseq_name": "olfactory receptor family 52 subfamily E member 7", "refseq_ac": "NP_667306", "gene_names_uniprotkb": "Or52e7; Olfr676", "gene_names_refseq": "MOR32-1; Olfr676; Or52e7", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-7664016-7664969; olfactory receptor 676; olfactory receptor MOR32-1; olfactory receptor family 52 subfamily E member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:259099)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VH17-1", "uniprot_id": "Q8VH17_MOUSE", "mass": 35682.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or51g1", "organism": "Mouse", "refseq_name": "olfactory receptor family 51 subfamily G member 1", "refseq_ac": "NP_667326", "gene_names_uniprotkb": "Or51g1; Olfr578", "gene_names_refseq": "MOR7-1; Olfr578; Or51g1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-5696486-5695545; olfactory receptor 578; olfactory receptor MOR7-1; olfactory receptor family 51 subfamily G member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:259119)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VH17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQD0-1", "uniprot_id": "RL39L_MOUSE", "mass": 6338.0, "length": 51, "protein_name": "Large ribosomal subunit protein eL39-like", "gene_name": "Rpl39l", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL39-like", "refseq_ac": "NP_080870", "gene_names_uniprotkb": "Rpl39l", "gene_names_refseq": "4930517K11Rik; Rpl39l", "protein_names_uniprotkb": "Large ribosomal subunit protein eL39-like; 60S ribosomal protein L39-like", "protein_names_refseq": "60S ribosomal protein L39-like; large ribosomal subunit protein eL39-like; ribosomal protein L39-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68172); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "17660561;24452241;34428590;34825148;36517592;39041433", "class_list": "", "function": "Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity., [RefSeq, PubMed]; Male germ cell-specific component of the ribosome, which is required for the formation of sperm and male fertility (PubMed:34825148, PubMed:36517592). Replaces the RPL39 paralog in the ribosome of male germ cells (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:34428590, PubMed:36517592). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (PubMed:36517592). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (PubMed:36517592)., [UniProtKB, PubMed, PubMed, PubMed]; Results show the RP paralog Rpl39l is highly expressed in Embryonic Stem Cells and its expression strongly correlates with hepatocellular carcinoma tumor (HCC) samples with high tumor grading and alpha-fetoprotein level giving it diagnostic potential., [RefSeq, PubMed]; Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0007283 spermatogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A087WR99-1", "uniprot_id": "A0A087WR99_MOUSE", "mass": 25605.0, "length": 222, "protein_name": "Predicted gene, 20890; 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AU022751; KIP75", "gene_names_refseq": "Ezhip; KIP75", "protein_names_uniprotkb": "EZH inhibitory protein; K27M-like inhibitor of PRC2", "protein_names_refseq": "EZH inhibitory protein isoform 1; K27M-like inhibitor of PRC2", "tax_id": 10090, "disease": "", "pathway": " (mmu:102991); (R-MMU-212300)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "31086175;31451685", "class_list": "", "function": "Deletion of Ezhip (EZH inhibitory protein) in mice leads to a global increase in H3K27me2/3 deposition both during spermatogenesis and at late stages of oocyte maturation. This does not affect the initial number of follicles but is associated with a reduction of follicles in aging. Study uncovers Ezhip as a regulator of chromatin landscape in gametes. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation at 'Lys-27' (H3K27me3) (PubMed:31086175). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (By similarity). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (PubMed:31451685)., [UniProtKB, PubMed, PubMed, UniProtKB]; Study revealed that CXORF67 contains a highly conserved 'K27M-like' sequence that is necessary and sufficient to inhibit PRC2 activity and reduce cellular H3K27me3 levels. Biochemical and cell-based studies demonstrate that CXORF67 functions as a K27M-like peptidyl inhibitor of PRC2. Therefore, study propose the name EZHIP (Enhancer of Zeste Homologs Inhibitory Protein) as a more descriptive for the function of CXORF67. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TL73;Q3UWZ4;Q497U5", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0180000 histone methyltransferase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006325 chromatin organization;GO:0040029 epigenetic regulation of gene expression;GO:0048599 oocyte development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B1B0V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX25-1", "uniprot_id": "CJ143_MOUSE", "mass": 11786.0, "length": 107, "protein_name": "Uncharacterized protein C10orf143 homolog", "gene_name": "9430038I01Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C10orf143 homolog", "refseq_ac": "NP_084162", "gene_names_uniprotkb": "9430038I01Rik", "gene_names_refseq": "9430038I01Rik", "protein_names_uniprotkb": "Uncharacterized protein C10orf143 homolog", "protein_names_refseq": "uncharacterized protein C10orf143 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:77252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CX25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YXJ9-1", "uniprot_id": "D3YXJ9_MOUSE", "mass": 24090.0, "length": 220, "protein_name": "Claudin", "gene_name": "Cldn24", "organism": "Mouse", "refseq_name": "putative claudin-24", "refseq_ac": "NP_001104788", "gene_names_uniprotkb": "Cldn24", "gene_names_refseq": "Cldn24; Gm10107", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "putative claudin-24", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039801)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the human homolog. Similar to the human gene, this gene is upstream of the Cldn22 gene, which overlaps the Wwc2 gene on the opposite strand. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YXJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z420-1", "uniprot_id": "D3Z420_MOUSE", "mass": 107852.0, "length": 943, "protein_name": "Family with sequence similarity 186, member B", "gene_name": "Fam186b", "organism": "Mouse", "refseq_name": "protein FAM186B", "refseq_ac": "NP_001074723", "gene_names_uniprotkb": "Fam186b", "gene_names_refseq": "EG545136; Fam186b", "protein_names_uniprotkb": "Family with sequence similarity 186, member B", "protein_names_refseq": "protein FAM186B", "tax_id": 10090, "disease": "", "pathway": " (mmu:545136)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z420-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PXV9-1", "uniprot_id": "OBOX2_MOUSE", "mass": 17304.0, "length": 151, "protein_name": "Inactive oocyte-specific homeobox protein 2", "gene_name": "Obox2", "organism": "Mouse", "refseq_name": "inactive oocyte-specific homeobox protein 2", "refseq_ac": "NP_663754", "gene_names_uniprotkb": "Obox2", "gene_names_refseq": "Obox2", "protein_names_uniprotkb": "Inactive oocyte-specific homeobox protein 2", "protein_names_refseq": "inactive oocyte-specific homeobox protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:246792)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11991721;37459895", "class_list": "", "function": "In contrast to other Obox family proteins, displays a truncated homeobox domain and does not bind DNA., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHG7", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9PXV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G5E8S3-1", "uniprot_id": "G5E8S3_MOUSE", "mass": 53444.0, "length": 482, "protein_name": "Riken cDNA E230025N22 gene", "gene_name": "E230025N22Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC240216", "refseq_ac": "NP_766419", "gene_names_uniprotkb": "E230025N22Rik", "gene_names_refseq": "E230025N22Rik; EG240216", "protein_names_uniprotkb": "Riken cDNA E230025N22 gene", "protein_names_refseq": "uncharacterized protein LOC240216", "tax_id": 10090, "disease": "", "pathway": " (mmu:240216)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G5E8S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "J3KMI9-1", "uniprot_id": "J3KMI9_MOUSE", "mass": 26625.0, "length": 230, "protein_name": "Predicted gene, 21719", "gene_name": "Gm21719", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gm21719", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 21719", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3KMI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "J3QK54-1", "uniprot_id": "FIGL2_MOUSE", "mass": 65922.0, "length": 644, "protein_name": "Fidgetin-like protein 2", "gene_name": "Fignl2", "organism": "Mouse", "refseq_name": "fidgetin-like protein 2", "refseq_ac": "NP_001201840", "gene_names_uniprotkb": "Fignl2", "gene_names_refseq": "EG668225; Fignl2", "protein_names_uniprotkb": "Fidgetin-like protein 2; 3.6.4.-", "protein_names_refseq": "fidgetin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:668225)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15707573;25756798;33872220", "class_list": "", "function": "Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule-severing enzyme that negatively regulates cell migration and wound healing (PubMed:25756798). In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (By similarity). Microtubule severing releases ARHGEF2 which activates RHOA, which in turn regulates focal ahesion turnover via focal adhesion kinase, as opposed to F-actin polymerization, to suppress cell motility (By similarity). Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (PubMed:33872220). Contributes to proper cell branching during endothelial and neuronal development (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0031252 cell leading edge", "go_biological_process": "GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0051013 microtubule severing;GO:0030336 negative regulation of cell migration;GO:0001763 morphogenesis of a branching structure;GO:0048681 negative regulation of axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "J3QK54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "J3QM72-1", "uniprot_id": "J3QM72_MOUSE", "mass": 26052.0, "length": 227, "protein_name": "Predicted gene, 20834", "gene_name": "Gm20834", "organism": "Mouse", "refseq_name": "Y-linked testis-specific protein 1-like", "refseq_ac": "XP_017174334", "gene_names_uniprotkb": "Gm20834", "gene_names_refseq": "Gm20834", "protein_names_uniprotkb": "Predicted gene, 20834", "protein_names_refseq": "Y-linked testis-specific protein 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:108168637)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, 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"go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QM72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "J3QQ23-1", "uniprot_id": "J3QQ23_MOUSE", "mass": 26617.0, "length": 232, "protein_name": "Predicted gene, 21310", "gene_name": "Gm21310", "organism": "Mouse", "refseq_name": "Y-linked testis-specific protein 1-like", "refseq_ac": "XP_011249339", "gene_names_uniprotkb": "Gm21310", "gene_names_refseq": "Gm21310", "protein_names_uniprotkb": "Predicted gene, 21310", "protein_names_refseq": "Y-linked testis-specific protein 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:100861899)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 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The highest relative activity is toward ERK1., [UniProtKB, UniProtKB]; Proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 actions, and tolerance, [RefSeq, PubMed]; Suppression of mutant Kirsten-RAS (KRAS(G12D))-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;2.7.11.24;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0045892 negative regulation of DNA-templated transcription;GO:0045906 negative regulation of vasoconstriction;GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q1HL35-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UD61-1", "uniprot_id": "MX1_MOUSE", "mass": 44947.0, "length": 397, "protein_name": "Protein Mx1", "gene_name": "Mx1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mx1; 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Olfr1346", "gene_names_refseq": "MOR103-6; Olfr1346; Or6z5", "protein_names_uniprotkb": "Olfactory receptor family 6 subfamily Z member 5", "protein_names_refseq": "GA_x6K02T2QGBW-3203957-3204898; olfactory receptor 1346; olfactory receptor MOR103-6; olfactory receptor family 6 subfamily Z member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:258918)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LHR7", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIC1-1", "uniprot_id": "Q8VIC1_MOUSE", "mass": 36546.0, "length": 319, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r69", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor, E9", "refseq_ac": "NP_665841", "gene_names_uniprotkb": "Vmn1r69", "gene_names_refseq": "V1re9; 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Olfr661", "gene_names_refseq": "MOR40-4; Olfr661; Or56b2", "protein_names_uniprotkb": "Olfactory receptor family 56 subfamily B member 2", "protein_names_refseq": "G-protein-coupled receptor; GA_x6K02T2PBJ9-7316375-7317334; odorant receptor S83; olfactory receptor 661; olfactory receptor MOR40-4; olfactory receptor family 56 subfamily B member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258743)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19166503;21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; The receptive range of MOR40-4 is unique to its odorant space region., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99NH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0T7-1", "uniprot_id": "TRY4_MOUSE", "mass": 26274.0, "length": 246, "protein_name": "Trypsin-4", "gene_name": "Try4", "organism": "Mouse", "refseq_name": "trypsin-4 precursor", "refseq_ac": "NP_035776", "gene_names_uniprotkb": "Try4; T8; Td", "gene_names_refseq": "0910001B19Rik; Td; Try4", "protein_names_uniprotkb": "Trypsin-4; 3.4.21.4", "protein_names_refseq": "trypsin-4 precursor", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:22074); (R-MMU-1442490); (R-MMU-1462054); (R-MMU-1592389); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10506205;11160223;23814066", "class_list": "", "function": "Serine protease capable of autoactivation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.4.24.22;3.4.24.34;3.4.22.27;1.1.1.42;4.1.2.13;3.4.21.4;3.4.21.-;3.2.1.17;1.16.3.1;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.4.23.5;3.2.1.52;3.4.21.39;3.4.21.59;3.2.1.23;3.3.2.6;3.4.11.4;3.4.21.34;3.4.21.20;3.4.24.17;2.7.10.2;2.7.11.13;3.1.3.48;3.4.24.-;3.4.24.35;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;3.5.4.5;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.24.23;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;1.8.3.2;5.3.99.3;6.3.4.21;2.4.1.1;3.6.1.6;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;3.4.21.1;2.3.2.5;5.4.2.2;3.2.1.14;1.6.2.2;3.4.24.7;3.4.14.2;3.5.1.3;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R0T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0I7-1", "uniprot_id": "SLFN1_MOUSE", "mass": 37996.0, "length": 337, "protein_name": "Schlafen family member 1", "gene_name": "Slfn1", "organism": "Mouse", "refseq_name": "schlafen family member 1", "refseq_ac": "NP_035537", "gene_names_uniprotkb": "Slfn1", "gene_names_refseq": "Slfn1", "protein_names_uniprotkb": "Schlafen family member 1; Schlafen-1", "protein_names_refseq": "schlafen family member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20555)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15946944;18373498;30059200;9846487", "class_list": "", "function": "DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle arrest and programmes a quiescent state of T-cells, [RefSeq, PubMed]; Protein expressed in resting T-cells, which is required for maintaining T-cells in the quiescent state (PubMed:15946944, PubMed:18373498, PubMed:9846487). Acts by promoting cell-cycle arrest of T-cells through inhibiting the expression of cyclin-D1 (CCND1) (PubMed:15946944)., [UniProtKB, PubMed, PubMed, PubMed]; Results suggest that Schlafen-1 causes a cell cycle arrest during G1 by inhibiting induction of cyclin D1 by mitogens. Erratum:[J Biol Chem. 2016 Nov 25;291(48):25278. doi: 10.1074/jbc.A116.500435. PMID: 27888236], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004540 RNA nuclease activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0001933 negative regulation of protein phosphorylation;GO:0042130 negative regulation of T cell proliferation;GO:0097190 apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A087WPW0-1", "uniprot_id": "A0A087WPW0_MOUSE", "mass": 10300.0, "length": 93, "protein_name": "Secretoglobin, family 1B, member 10", "gene_name": "Scgb1b10", "organism": "Mouse", "refseq_name": "major allergen I polypeptide chain 1", "refseq_ac": "XP_006540554", "gene_names_uniprotkb": "Scgb1b10", "gene_names_refseq": "Scgb1b10", "protein_names_uniprotkb": "Secretoglobin, family 1B, member 10", "protein_names_refseq": "major allergen I polypeptide chain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:102635992)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005496 steroid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WPW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2JDG3-1", "uniprot_id": "A0A0G2JDG3_MOUSE", "mass": 1895.0, "length": 19, "protein_name": "T cell receptor alpha joining 12", "gene_name": "Traj12", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Traj12", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha joining 12", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JDG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A140T8K4-1", "uniprot_id": "A0A140T8K4_MOUSE", "mass": 35216.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or5k8", "organism": "Mouse", "refseq_name": "olfactory receptor 174", "refseq_ac": "NP_667213", "gene_names_uniprotkb": "Or5k8; Olfr175-ps1; Olfr175", "gene_names_refseq": "MOR184-10P; MOR184-1; Olfr174; Olfr175-ps1; Olfr175; Or5k8", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x54KRFPKG5P-54993816-54992890; GA_x54KRFPKG5P-55026345-55025418; olfactory receptor 174; olfactory receptor 175, pseudogene 1; olfactory receptor MOR184-10P", "tax_id": 10090, "disease": "", "pathway": " (mmu:259004)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140T8K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AML7-1", "uniprot_id": "A2AML7_MOUSE", "mass": 61932.0, "length": 551, "protein_name": "Zinc finger protein 352", "gene_name": "Zfp352", "organism": "Mouse", "refseq_name": "Kruppel-like factor 18", "refseq_ac": "NP_694742", "gene_names_uniprotkb": "Zfp352", "gene_names_refseq": "2czf48; Zfp352", "protein_names_uniprotkb": "Zinc finger protein 352", "protein_names_refseq": "Kruppel-like factor 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:236537)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12420299;21750661;37339952;37778747", "class_list": "", "function": "Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network. 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Gm4133; Gm4187; Vmn1r253", "gene_names_refseq": "100042964; Gm4133; Vmn1r243; Vmn1r98", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomeronasal 1 receptor Vmn1r98", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042964); (mmu:100043043)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K9J7G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "L7N1Z8-1", "uniprot_id": "L7N1Z8_MOUSE", "mass": 35295.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or5h23", "organism": "Mouse", "refseq_name": "olfactory receptor 191", "refseq_ac": "NP_001011807", "gene_names_uniprotkb": "Or5h23; Olfr191", "gene_names_refseq": "MOR183-5P; Olfr191; Or5h23", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x54KRFPKG5P-55314632-55313703; olfactory receptor 191; olfactory receptor MOR183-5P", "tax_id": 10090, "disease": "", "pathway": " (mmu:258035)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N1Z8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14BQ3-1", "uniprot_id": "CT55_MOUSE", "mass": 26281.0, "length": 236, "protein_name": "Cancer/testis antigen 55", "gene_name": "Ct55", "organism": "Mouse", "refseq_name": "cancer/testis antigen 55", "refseq_ac": "NP_083418", "gene_names_uniprotkb": "Ct55", "gene_names_refseq": "4930502E18Rik; Ct55", "protein_names_uniprotkb": "Cancer/testis antigen 55", "protein_names_refseq": "cancer/testis antigen 55", "tax_id": 10090, "disease": "X-linked spermatogenic failure 7 (Disease Ontology:DOID:0070598)", "pathway": " (mmu:75013)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30944312;36481789", "class_list": "", "function": "CT55 acts as an accelerator of tumor necrosis factor (TNF)-alpha-induced nuclear factor-kappaB (NF-kappaB) signaling. Upon stimulation with TNF-alpha, CT55 interacts with the IkappaB kinase (IKK) complex, which increases the phosphorylation of IKKalpha/beta and activates IKK-p65 signaling, while knockout of CT55 blocks IKK-p65 signaling. Collectively, CT55 deficiency suppresses the development of colitis-associated can... Publication Status: Online-Only, [RefSeq, PubMed]; Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice., [RefSeq, PubMed]; Plays a role in spermatogenesis, possibly acting in the regulation of the autophagy pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D585", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q14BQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UJB0-1", "uniprot_id": "SF3B2_MOUSE", "mass": 98198.0, "length": 878, "protein_name": "Splicing factor 3B subunit 2", "gene_name": "Sf3b2", "organism": "Mouse", "refseq_name": "splicing factor 3B subunit 2 isoform 1", "refseq_ac": "NP_084385", "gene_names_uniprotkb": "Sf3b2", "gene_names_refseq": "145kDa; 2610311M13Rik; 2810441F20Rik; B230398H18Rik; SAP145; SF3b145; SF3b150; SF3b1; Sf3b2", "protein_names_uniprotkb": "Splicing factor 3B subunit 2", "protein_names_refseq": "splicing factor 3B subunit 2 isoform 1", "tax_id": 10090, "disease": "Goldenhar syndrome (Disease Ontology:DOID:2907)", "pathway": " (mmu:319322); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;25605945;33712605;34887587;36574260", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]; Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis., [RefSeq, PubMed]; PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A494B9S9;Q3UAI4;Q3UBH2;Q3UQU5;Q80W39;Q8BL33;Q9CS24", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UJB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQW8-1", "uniprot_id": "Q7TQW8_MOUSE", "mass": 35344.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or4f60", "organism": "Mouse", "refseq_name": "olfactory receptor 1313", "refseq_ac": "NP_997033", "gene_names_uniprotkb": "Or4f60; Olfr1313", "gene_names_refseq": "MOR245-23; Olfr1313; Or4f60", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-73119859-73118924; olfactory receptor 1313; olfactory receptor MOR245-23", "tax_id": 10090, "disease": "", "pathway": " (mmu:258257)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQX0-1", "uniprot_id": "Q7TQX0_MOUSE", "mass": 36537.0, "length": 320, "protein_name": "Olfactory receptor", "gene_name": "Or4f57", "organism": "Mouse", "refseq_name": "olfactory receptor family 4 subfamily F member 57", "refseq_ac": "NP_997034", "gene_names_uniprotkb": "Or4f57; Olfr1308; Olfr1312", "gene_names_refseq": "MOR245-22; Olfr1308; Or4f57", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-73008844-73007882; olfactory receptor 1308; olfactory receptor MOR245-22; olfactory receptor family 4 subfamily F member 57", "tax_id": 10090, "disease": "", "pathway": " (mmu:258258)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TS06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFW6-1", "uniprot_id": "ENTP3_MOUSE", "mass": 58984.0, "length": 529, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 3", "gene_name": "Entpd3", "organism": "Mouse", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 3", "refseq_ac": "NP_848791", "gene_names_uniprotkb": "Entpd3", "gene_names_refseq": "Cd39l3; Entpd3; HB6; NTPDase-3", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 3; 3.6.1.5; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ecto-ATPase 3; NTPDase3", "protein_names_refseq": "CD39 antigen-like 3; NTPDase 3; NTPDase3; ecto-ATP diphosphohydrolase 3; ecto-ATPDase 3; ecto-ATPase 3; ectonucleoside triphosphate diphosphohydrolase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:215446); (R-MMU-8850843)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15130768;21233276;22645316;27706204;28472257;30899004;33631144", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:15130768). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:15130768). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:15130768). Has a threefold preference for the hydrolysis of ATP and UTP over ADP (PubMed:15130768). Does not hydrolyzes AMP (PubMed:15130768)., [UniProtKB, PubMed]; Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism., [RefSeq, PubMed]; NTPDase2 and -3 are ecto-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease., [RefSeq, PubMed]; Results identified the expression of ecto-NTPDase3 in trigeminal nociceptive neurons and demonstrated the presence of functional ecto-ATPase activity in trigeminal nerves and established that ecto-NTPDase3mediates extracellularATP degradation in the nociceptive lamina on the brainstem. Publication Status: Online-Only, [RefSeq, PubMed]; The specific localization of NTPDase3 in the digestive system suggests functional roles of the enzyme, in association with NTPDase2 and ecto-5'-nucleotidase, in epithelial functions such as secretion and in enteric neurotransmission., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9PYV0;Q3TC04;Q3TDX3", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;3.6.1.6;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;3.6.1.42", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0017110 nucleoside diphosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009143 nucleoside triphosphate catabolic process;GO:0009203 ribonucleoside triphosphate catabolic process;GO:0009191 ribonucleoside diphosphate catabolic process;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BFW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4L6-1", "uniprot_id": "MEPE_MOUSE", "mass": 46872.0, "length": 441, "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "Mepe", "organism": "Mouse", "refseq_name": "matrix extracellular phosphoglycoprotein precursor", "refseq_ac": "NP_444402", "gene_names_uniprotkb": "Mepe", "gene_names_refseq": "Mepe; Of45", "protein_names_uniprotkb": "Matrix extracellular phosphoglycoprotein; OF45; Osteoblast/osteocyte factor 45; Osteoregulin", "protein_names_refseq": "matrix extracellular phosphoglycoprotein precursor; osteoblast/osteocyte factor 45; osteoregulin", "tax_id": 10090, "disease": "", "pathway": " (mmu:94111); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11414762;12220505;12421822;15221418;15329369;15843468;18597632;19924383;22042093;22766095;26051469;26428891;26495903;26927967;34428180", "class_list": "", "function": "An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. Publication Status: Online-Only, [RefSeq, PubMed]; MEPE may be involved in the pathogenesis defective mineralization due to Phex deficiency in X-linked hypophosphatemia (XLH) and the Hyp-mouse., [RefSeq, PubMed]; Mepe appears to play a role in both long bone regeneration and the latter stages of skeletogenesis., [RefSeq, PubMed]; Mepe(-/-) molars exhibited increased thickness of predentin, dentin, and enamel over controls and decreased gene expression of Enam, Bsp, Dmp1, Dspp, and Opn by RT-PCR., [RefSeq, PubMed]; Regulates renal phosphate and uric acid excretion (PubMed:26051469). Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:11414762, PubMed:12421822, PubMed:15843468, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (PubMed:26927967). Increases dental pulp stem cell proliferation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6C6N6;Q3TYZ5;Q924I1", "ec_number_list": "", "go_molecular_function": "GO:1990430 extracellular matrix protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001501 skeletal system development;GO:0031214 biomineral tissue development;GO:0030502 negative regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K4L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R276-1", "uniprot_id": "Q8R276_MOUSE", "mass": 36771.0, "length": 316, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r205", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 205", "refseq_ac": "NP_598978", "gene_names_uniprotkb": "Vmn1r205", "gene_names_refseq": "V1rh8; Vmn1r205", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r205; vomeronasal 1 receptor 205; vomeronasal 1 receptor, H8", "tax_id": 10090, "disease": "", "pathway": " (mmu:171251)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R276-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R289-1", "uniprot_id": "Q8R289_MOUSE", "mass": 34263.0, "length": 305, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r75", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 75", "refseq_ac": "NP_598968", "gene_names_uniprotkb": "Vmn1r75", "gene_names_refseq": "V1rg6; Vmn1r75", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r75; vomeronasal 1 receptor 75; vomeronasal 1 receptor, G6; vomeronasal type 1 receptor G6", "tax_id": 10090, "disease": "", "pathway": " (mmu:171241)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2B4-1", "uniprot_id": "Q8R2B4_MOUSE", "mass": 36794.0, "length": 323, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r179", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 179", "refseq_ac": "NP_997428", "gene_names_uniprotkb": "Vmn1r179", "gene_names_refseq": "V1rd17; Vmn1r179", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r179; vomeronasal 1 receptor 179; vomeronasal 1 receptor, D17", "tax_id": 10090, "disease": "", "pathway": " (mmu:404286)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEV0-1", "uniprot_id": "Q8VEV0_MOUSE", "mass": 34804.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or2a12", "organism": "Mouse", "refseq_name": "olfactory receptor family 2 subfamily A member 12", "refseq_ac": "NP_666407", "gene_names_uniprotkb": "Or2a12; Olfr446", "gene_names_refseq": "MOR261-12; Olfr446; Or2a12", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2P3E9-4632269-4631343; olfactory receptor 446; olfactory receptor MOR261-12; olfactory receptor family 2 subfamily A member 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:258292)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VEV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEZ6-1", "uniprot_id": "Q8VEZ6_MOUSE", "mass": 35387.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or1e1f", "organism": "Mouse", "refseq_name": "olfactory receptor family 1 subfamily E member 1F", "refseq_ac": "NP_666458", "gene_names_uniprotkb": "Or1e1f; Olfr23; Olfr397", "gene_names_refseq": "MOR135-28; Olfr397; Or1e1f", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2P1NL-4121434-4122381; olfactory receptor 397; olfactory receptor MOR135-28; olfactory receptor family 1 subfamily E member 1F", "tax_id": 10090, "disease": "", "pathway": " (mmu:258343)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGZ8-1", "uniprot_id": "Q8VGZ8_MOUSE", "mass": 36040.0, "length": 319, "protein_name": "Olfactory receptor", "gene_name": "Or51l14", "organism": "Mouse", "refseq_name": "olfactory receptor family 51 subfamily L member 14", "refseq_ac": "NP_667305", "gene_names_uniprotkb": "Or51l14; Olfr606", "gene_names_refseq": "MOR17-2; Olfr606; Or51l14", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-6173009-6173968; olfactory receptor 606; olfactory receptor MOR17-2; olfactory receptor family 51 subfamily L member 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:259098)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EP55-1", "uniprot_id": "Q9EP55_MOUSE", "mass": 35209.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or2d4", "organism": "Mouse", "refseq_name": "olfactory receptor 710", "refseq_ac": "NP_666812", "gene_names_uniprotkb": "Or2d4; Olfr710", "gene_names_refseq": "MOR260-3; Olfr710; Or2d4", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "B3 olfactory receptor; GA_x6K02T2PBJ9-9325348-9324416; olfactory receptor 710; olfactory receptor MOR260-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258594)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EP55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPN9-1", "uniprot_id": "Q9EPN9_MOUSE", "mass": 35054.0, "length": 317, "protein_name": "Olfactory receptor family 51 subfamily AI member 2", "gene_name": "Or51ai2", "organism": "Mouse", "refseq_name": "olfactory receptor family 51 subfamily AI member 2", "refseq_ac": "NP_667330", "gene_names_uniprotkb": "Or51ai2; Olfr632", "gene_names_refseq": "MOR2-1; Olfr632; Or51ai2", "protein_names_uniprotkb": "Olfactory receptor family 51 subfamily AI member 2", "protein_names_refseq": "GA_x6K02T2PBJ9-6671256-6672209; olfactory receptor 632; olfactory receptor MOR2-1; olfactory receptor family 51 subfamily AI member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:259123); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EPN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ93-1", "uniprot_id": "Q9EQ93_MOUSE", "mass": 35295.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or8g24", "organism": "Mouse", "refseq_name": "olfactory receptor family 8 subfamily G member 24", "refseq_ac": "NP_666649", "gene_names_uniprotkb": "Or8g24; Olfr938", "gene_names_refseq": "MOR171-25; Olfr938; Or8g24", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-32774646-32773699; olfactory receptor 938; olfactory receptor MOR171-25; olfactory receptor family 8 subfamily G member 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:258430)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EQ93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ98-1", "uniprot_id": "Q9EQ98_MOUSE", "mass": 34559.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or8d2b", "organism": "Mouse", "refseq_name": "olfactory receptor family 8 subfamily D member 2D", "refseq_ac": "NP_667026", "gene_names_uniprotkb": "Or8d2b; Olfr926", "gene_names_refseq": "MOR171-8; Olfr926; Or8d2b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-32573036-32573962; olfactory receptor 926; olfactory receptor MOR171-8; olfactory receptor family 8 subfamily D member 2D", "tax_id": 10090, "disease": "", "pathway": " (mmu:258811)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EQ98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0I6-1", "uniprot_id": "SLFN2_MOUSE", "mass": 42438.0, "length": 378, "protein_name": "Schlafen family member 2", "gene_name": "Slfn2", "organism": "Mouse", "refseq_name": "schlafen family member 2", "refseq_ac": "NP_035538", "gene_names_uniprotkb": "Slfn2", "gene_names_refseq": "Shlf2; Slfn2", "protein_names_uniprotkb": "Schlafen family member 2; Schlafen-2", "protein_names_refseq": "schlafen family member 12-like; schlafen family member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20556)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17434208;18479948;19592487;20190759;27276683;28672048;29866656;30158544;30275530;33986151;35615926;9846487", "class_list": "", "function": "Overall, these data suggest that Slfn2 is required for normal osteoclast differentiation and that loss of its function in mice results in an osteopetrotic phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity., [RefSeq, PubMed]; Schlafen1 and Schlafen2 failed to inhibit cell proliferation, cause G1 cell cycle arrest, or affect Cyclin D1 level in murine fibroblasts., [RefSeq, PubMed]; Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; The Slfn-2 transcriptional start site and transcription factor binding sites in the slfn-2 promoter have been identified., [RefSeq, PubMed]; We provide evidence that targeted disruption of the Slfn2 gene leads to increased transcription of IFN-stimulated genes (ISGs) and enhanced type I IFN-mediated antiviral responses Publication Status: Online-Only, [RefSeq, PubMed]; tRNA-binding protein involved in T-cell mediated immunity (PubMed:33986151). Plays a key role during the metabolic reprograming phase of activated T-cell, when T-cells produce reactive oxygen species (ROS): acts by binding tRNAs and protecting them from cleavage by the oxidative stress-activated ribonuclease angiogenin (ANG) (PubMed:33986151). Also required for T-cell quiescence maintenance (PubMed:20190759)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0004540 RNA nuclease activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0097190 apoptotic signaling pathway;GO:0009617 response to bacterium;GO:0016075 rRNA catabolic process;GO:0002456 T cell mediated immunity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z0I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2JDD5-1", "uniprot_id": "A0A0G2JDD5_MOUSE", "mass": 969.0, "length": 9, "protein_name": "Immunoglobulin heavy diversity 5-7; Immunoglobulin heavy diversity 5-8; Predicted gene, 37327", "gene_name": "Ighd6-4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighd6-4; Gm37327; Ighd5-7; Ighd5-8; Ighd6-2-1; Ighd6-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy diversity 5-7; Immunoglobulin heavy diversity 5-8; Predicted gene, 37327", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JDD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A140T8J6-1", "uniprot_id": "A0A140T8J6_MOUSE", "mass": 34801.0, "length": 310, "protein_name": "Olfactory receptor family 10 subfamily J member 2", "gene_name": "Or10j2", "organism": "Mouse", "refseq_name": "olfactory receptor 1403", "refseq_ac": "NP_666862", "gene_names_uniprotkb": "Or10j2; Olfr418", "gene_names_refseq": "MOR267-12P; MOR267-8; Olfr1403; Olfr418-ps1; Olfr418; Or10j2", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily J member 2", "protein_names_refseq": "GA_x6K02T2P20D-20826777-20827719; GA_x6K02T2R7CC-581296-580364; olfactory receptor 1403; olfactory receptor 418, pseudogene 1; olfactory receptor MOR267-12P; olfactory receptor MOR267-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:258645)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140T8J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1B0GRQ0-1", "uniprot_id": "SIM36_MOUSE", "mass": 10272.0, "length": 93, "protein_name": "Small integral membrane protein 36", "gene_name": "Smim36", "organism": "Mouse", "refseq_name": "small integral membrane protein 36", "refseq_ac": "NP_001382351", "gene_names_uniprotkb": "Smim36; Gm45716", "gene_names_refseq": "Gm45716; Smim36", "protein_names_uniprotkb": "Small integral membrane protein 36", "protein_names_refseq": "small integral membrane protein 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:121811722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1B0GRQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1C7CYV3-1", "uniprot_id": "A0A1C7CYV3_MOUSE", "mass": 57890.0, "length": 506, "protein_name": "Zinc finger and SCAN domain containing 4, pseudogene 1", "gene_name": "Zscan4-ps1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zscan4-ps1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger and SCAN domain containing 4, pseudogene 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A916LM20", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1C7CYV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1W2P860-1", "uniprot_id": "A0A1W2P860_MOUSE", "mass": 28477.0, "length": 280, "protein_name": "Keratin associated protein 10-32", "gene_name": "Krtap10-32", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Krtap10-32; Gm18596", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin associated protein 10-32", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-6805567)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P860-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1W2P8D5-1", "uniprot_id": "A0A1W2P8D5_MOUSE", "mass": 15917.0, "length": 158, "protein_name": "Keratin associated protein 10-35", "gene_name": "Krtap10-35", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC102639995", "refseq_ac": "NP_001357764", "gene_names_uniprotkb": "Krtap10-35; 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Gm11565", "gene_names_refseq": "Gm11565; Krtap31-3", "protein_names_uniprotkb": "Keratin associated protein 31-3", "protein_names_refseq": "keratin associated protein 31-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:670550); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A4M7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AFK4-1", "uniprot_id": "A2AFK4_MOUSE", "mass": 44003.0, "length": 405, "protein_name": "Mitochondrial ribosome-associated GTPase 2", "gene_name": "Mtg2", "organism": "Mouse", "refseq_name": "mitochondrial ribosome-associated GTPase 2", "refseq_ac": "NP_001076797", "gene_names_uniprotkb": "Mtg2; Gtpbp5", "gene_names_refseq": "1810011P19Rik; 2900056P18Rik; D2Bwg0647e; Gtpbp5; Mtg2", "protein_names_uniprotkb": "Mitochondrial ribosome-associated GTPase 2; GTP-binding protein 5", "protein_names_refseq": "GTP binding protein 5; mitochondrial ribosome-associated GTPase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52856)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0070129 regulation of mitochondrial translation;GO:0044065 regulation of respiratory system process;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AFK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AGU5-1", "uniprot_id": "A2AGU5_MOUSE", "mass": 23884.0, "length": 210, "protein_name": "Claudin 34D", "gene_name": "Cldn34d", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC74987", "refseq_ac": "NP_001188324", "gene_names_uniprotkb": "Cldn34d", "gene_names_refseq": "4930468A15Rik; Cldn34d", "protein_names_uniprotkb": "Claudin 34D", "protein_names_refseq": "uncharacterized protein LOC74987", "tax_id": 10090, "disease": "", "pathway": " (mmu:74987)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AGU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AU34-1", "uniprot_id": "A2AU34_MOUSE", "mass": 24971.0, "length": 232, "protein_name": "Transmembrane protein 74B", "gene_name": "Tmem74b", "organism": "Mouse", "refseq_name": "transmembrane protein 74B", "refseq_ac": "NP_001153835", "gene_names_uniprotkb": "Tmem74b; 5430405G05Rik", "gene_names_refseq": "5430405G05Rik; Tmem74b", "protein_names_uniprotkb": "Transmembrane protein 74B", "protein_names_refseq": "transmembrane protein 74B", "tax_id": 10090, "disease": "", "pathway": " (mmu:108832)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AU34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6X8J1-1", "uniprot_id": "A6X8J1_MOUSE", "mass": 18035.0, "length": 155, "protein_name": "Predicted gene 16405; Predicted gene 16430", "gene_name": "Gm16405", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100040894", "refseq_ac": "NP_001160073", "gene_names_uniprotkb": "Gm16405; Gm14594; Gm16430; Gm7958", "gene_names_refseq": "EG666120; Gm16430", "protein_names_uniprotkb": "Predicted gene 16405; Predicted gene 16430", "protein_names_refseq": "uncharacterized protein LOC100040894", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040867); (mmu:100040894); (mmu:666096); (mmu:666161)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "20395201;21750661", "class_list": "", "function": "X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6X8J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AYN9-1", "uniprot_id": "B1AYN9_MOUSE", "mass": 47056.0, "length": 409, "protein_name": "Testis expressed 28", "gene_name": "Tex28", "organism": "Mouse", "refseq_name": "testis-specific protein TEX28", "refseq_ac": "NP_001119960", "gene_names_uniprotkb": "Tex28", "gene_names_refseq": "Gm1538; Gm1811; Tex28", "protein_names_uniprotkb": "Testis expressed 28", "protein_names_refseq": "testis-specific protein TEX28", "tax_id": 10090, "disease": "", "pathway": " (mmu:385380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AYN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YUU5-1", "uniprot_id": "D3YUU5_MOUSE", "mass": 13259.0, "length": 139, "protein_name": "Late cornified envelope 1J", "gene_name": "Lce1j", "organism": "Mouse", "refseq_name": "late cornified envelope 1J", "refseq_ac": "NP_001268428", "gene_names_uniprotkb": "Lce1j", "gene_names_refseq": "Lce1j; Sprrl8", "protein_names_uniprotkb": "Late cornified envelope 1J", "protein_names_refseq": "late cornified envelope 1J; small proline rich-like 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:545547)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YUU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X8Y1-1", "uniprot_id": "TRI55_MOUSE", "mass": 60138.0, "length": 545, "protein_name": "Tripartite motif-containing 55", "gene_name": "Trim55", "organism": "Mouse", "refseq_name": "tripartite motif-containing 55", "refseq_ac": "NP_001074750", "gene_names_uniprotkb": "Trim55", "gene_names_refseq": "D830041C10Rik; MuRF-2; Murf2; Rnf29; Trim55", "protein_names_uniprotkb": "Tripartite motif-containing 55; 2.3.2.27; MuRF-2; MuRF2; Muscle-specific RING finger protein 2", "protein_names_refseq": "muscle-specific RING finger protein 2; ring finger protein 29; tripartite motif-containing 55; tripartite motif-containing protein 55", "tax_id": 10090, "disease": "", "pathway": " (mmu:381485)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18157088;20149877;21750661;23512667;24129315;29435413;32340625;32463795;37816088", "class_list": "", "function": "Data suggest that expression of MuRF1 is required for remodeling of type-II fibers under pathophysiological stress states, whereas MuRF1 and MuRF2 together are required for maintenance of type-II fibers, possibly via the regulation of myozenin-1., [RefSeq, PubMed]; Double knockout (dKO) mice obtained by the inactivation of all four MuRF1 and MuRF2 alleles developed extreme cardiac and milder skeletal muscle hypertrophy., [RefSeq, PubMed]; E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (PubMed:23512667). Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase (PubMed:32463795). Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome (PubMed:37816088). May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA (PubMed:29435413). Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM55 promotes noncanonical NF-kappaB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6Y1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0070936 protein K48-linked ubiquitination;GO:0007249 canonical NF-kappaB signal transduction;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "G3X8Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X946-1", "uniprot_id": "G3X946_MOUSE", "mass": 61334.0, "length": 537, "protein_name": "Flavin-containing monooxygenase", "gene_name": "Gm4847", "organism": "Mouse", "refseq_name": "flavin-containing monooxygenase 12", "refseq_ac": "NP_001157784", "gene_names_uniprotkb": "Gm4847", "gene_names_refseq": "EG226604; Fmo12; Gm4847", "protein_names_uniprotkb": "Flavin-containing monooxygenase; 1.-.-.-", "protein_names_refseq": "flavin-containing monooxygenase 12", "tax_id": 10090, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (mmu:226604)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.-.-.-;1.14.13.148;1.14.13.8;1.14.13.32;1.6.3.1", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0034899 trimethylamine monooxygenase activity;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity;GO:0047822 hypotaurine monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G5E8I7-1", "uniprot_id": "U17LC_MOUSE", "mass": 61483.0, "length": 545, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein C", "gene_name": "Usp17lc", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 17-like protein C", "refseq_ac": "NP_034219", "gene_names_uniprotkb": "Usp17lc; DUB-2; Dub2; Usp17l5", "gene_names_refseq": "Dub-2; Dub2b; Dub2; Usp17l5; Usp17lc", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 17-like protein C; 3.4.19.12; Deubiquitinating enzyme 2", "protein_names_refseq": "deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 17-like protein C; ubiquitin specific peptidase 17-like 5", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:13532); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11443643;12447969;22984479;8995226", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes (PubMed:11443643, PubMed:8995226). Important for preimplantation stage embryonic development (PubMed:22984479)., [UniProtKB, PubMed, PubMed, PubMed]; Induced by cytokines in lymphocytees [review] Review article, [RefSeq, PubMed]; The targeted disruption of Dub-2 may cause embryonic lethality during early gestation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55190;O55191", "ec_number_list": "3.4.19.12;3.1.3.48;3.4.26.1;3.6.4.13", "go_molecular_function": "GO:0003723 RNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0042981 regulation of apoptotic process;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G5E8I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "J3QP15-1", "uniprot_id": "J3QP15_MOUSE", "mass": 12202.0, "length": 125, "protein_name": "Late cornified envelope 1K", "gene_name": "Lce1k", "organism": "Mouse", "refseq_name": "late cornified envelope 1K", "refseq_ac": "NP_001241689", "gene_names_uniprotkb": "Lce1k", "gene_names_refseq": "631101; Gm7055; Lce1k; Sprrl6", "protein_names_uniprotkb": "Late cornified envelope 1K", "protein_names_refseq": "late cornified envelope 1K; small proline rich-like 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:631101)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QP15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0P5-1", "uniprot_id": "ENTP6_MOUSE", "mass": 49799.0, "length": 455, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 6", "gene_name": "Entpd6", "organism": "Mouse", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 6 isoform 1", "refseq_ac": "NP_742115", "gene_names_uniprotkb": "Entpd6; Cd39l2", "gene_names_refseq": "2700026H11Rik; Cd39l2; Entpd6; NTPDase-6", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 6; 3.6.1.6; CD39 antigen-like 2; NTPDase 6", "protein_names_refseq": "CD39 antigen-like 2; NTPDase 6; ectonucleoside triphosphate diphosphohydrolase 6 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12497); (R-MMU-8850843)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;26495903;32152506", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.1.5;3.6.1.-;3.6.5.-;3.6.1.6;3.6.1.15;3.6.1.42", "go_molecular_function": "GO:0005524 ATP binding;GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0008894 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity;GO:0017110 nucleoside diphosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0051592 response to calcium ion;GO:0032026 response to magnesium ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U0P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SW50-1", "uniprot_id": "Q5SW50_MOUSE", "mass": 35406.0, "length": 311, "protein_name": "Olfactory receptor family 4 subfamily D member 2B", "gene_name": "Or4d2b", "organism": "Mouse", "refseq_name": "olfactory receptor 462", "refseq_ac": "NP_666523", "gene_names_uniprotkb": "Or4d2b; Olfr462", "gene_names_refseq": "MOR240-3; Olfr462; Or4d2b", "protein_names_uniprotkb": "Olfactory receptor family 4 subfamily D member 2B", "protein_names_refseq": "GA_x6K02T2PAEV-9536824-9535889; olfactory receptor 462; olfactory receptor MOR240-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258406); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SW50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQV4-1", "uniprot_id": "Q7TQV4_MOUSE", "mass": 34668.0, "length": 312, "protein_name": "Olfactory receptor family 13 subfamily P member 3", "gene_name": "Or13p3", "organism": "Mouse", "refseq_name": "olfactory receptor 1341", "refseq_ac": "NP_667064", "gene_names_uniprotkb": "Or13p3; Olfr1341", "gene_names_refseq": "MOR258-1; Olfr1341; Or13p3", "protein_names_uniprotkb": "Olfactory receptor family 13 subfamily P member 3", "protein_names_refseq": "GA_x6K02T2QD9B-18838170-18837232; olfactory receptor 1341; olfactory receptor MOR258-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFM5-1", "uniprot_id": "Q8VFM5_MOUSE", "mass": 35283.0, "length": 316, "protein_name": "Olfactory receptor family 2 subfamily AG member 18", "gene_name": "Or2ag18", "organism": "Mouse", "refseq_name": "olfactory receptor 700", "refseq_ac": "NP_666811", "gene_names_uniprotkb": "Or2ag18; Olfr700; Olfr705", "gene_names_refseq": "MOR283-4; Olfr700; Or2ag18", "protein_names_uniprotkb": "Olfactory receptor family 2 subfamily AG member 18", "protein_names_refseq": "GA_x6K02T2PBJ9-9184187-9183237; olfactory receptor 700; olfactory receptor MOR283-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:258593)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFP9-1", "uniprot_id": "Q8VFP9_MOUSE", "mass": 34535.0, "length": 309, "protein_name": "Olfactory receptor family 1 subfamily J member 15", "gene_name": "Or1j15", "organism": "Mouse", "refseq_name": "olfactory receptor family 1 subfamily J member 15", "refseq_ac": "NP_666839", "gene_names_uniprotkb": "Or1j15; Olfr344", "gene_names_refseq": "MOR136-12; Olfr344; Or1j15", "protein_names_uniprotkb": "Olfactory receptor family 1 subfamily J member 15", "protein_names_refseq": "GA_x6K02T2NLDC-33262744-33263673; olfactory receptor 344; olfactory receptor MOR136-12; olfactory receptor family 1 subfamily J member 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:258621)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Olfr1337", "gene_names_refseq": "MOR259-10; Olfr1337; Olfr219-ps1; Or10ak13", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily AK member 13", "protein_names_refseq": "olfactory receptor 1337; olfactory receptor 219, pseudogene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258306)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (PubMed:22095711)., [UniProtKB, PubMed, PubMed]; Two splice variants of mGBP4 could be detected. One variant led to a premature stop codon after 312 bp. 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Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.-", "go_molecular_function": "GO:0106432 queuosine nucleosidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006400 tRNA modification;GO:0043174 nucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3X8U3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X9N3-1", "uniprot_id": "G3X9N3_MOUSE", "mass": 71755.0, "length": 661, "protein_name": "PNMA family member 8B", "gene_name": "Pnma8b", "organism": "Mouse", "refseq_name": "paraneoplastic antigen-like protein 8B", "refseq_ac": "NP_001093106", "gene_names_uniprotkb": "Pnma8b; Pnmal2", "gene_names_refseq": "EG434128; Pnma8b; Pnmal2", "protein_names_uniprotkb": "PNMA family member 8B", "protein_names_refseq": "PNMA-like 2; paraneoplastic antigen-like protein 8B", "tax_id": 10090, "disease": "", "pathway": " (mmu:434128)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X9N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "L7N457-1", "uniprot_id": "L7N457_MOUSE", "mass": 34929.0, "length": 313, "protein_name": "Olfactory receptor family 10 subfamily G member 3B", "gene_name": "Or10g3b", "organism": "Mouse", "refseq_name": "olfactory receptor 1513", "refseq_ac": "NP_001012269", "gene_names_uniprotkb": "Or10g3b; Olfr1513", "gene_names_refseq": "MOR223-10; MOR223-7P; MOR30B; Olfr1513; Or10g3b", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily G member 3B", "protein_names_refseq": "GA_x5J8B7TYTVL-817-1341; GA_x6K02T2RJGY-644134-645075; olfactory receptor 1513; olfactory receptor MOR223-7P", "tax_id": 10090, "disease": "", "pathway": " (mmu:258008)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89010-1", "uniprot_id": "O89010_MOUSE", "mass": 36640.0, "length": 325, "protein_name": "MAGE family member A6", "gene_name": "Magea6", "organism": "Mouse", "refseq_name": "melanoma antigen family A, 6", "refseq_ac": "NP_064403", "gene_names_uniprotkb": "Magea6", "gene_names_refseq": "Mage-a6; Magea6", "protein_names_uniprotkb": "MAGE family member A6", "protein_names_refseq": "melanoma antigen family A, 6; melanoma antigen, family A, 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:17142)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;36341564", "class_list": "", "function": "Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0089720 caspase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O89010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62007-1", "uniprot_id": "O10J5_MOUSE", "mass": 34256.0, "length": 309, "protein_name": "Olfactory receptor 10J5", "gene_name": "Or10j5", "organism": "Mouse", "refseq_name": "olfactory receptor 10J5", "refseq_ac": "NP_032789", "gene_names_uniprotkb": "Or10j5; Mor23; Olfr16", "gene_names_refseq": "MOR23; MOR26713; Olfr16; Or10j5", "protein_names_uniprotkb": "Olfactory receptor 10J5; Olfactory receptor 16", "protein_names_refseq": "olfactory receptor 10J5; olfactory receptor 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:18313); (R-MMU-381753)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10097159;15522887;19922870;25791473;28842679;39417398;8619840", "class_list": "", "function": "MOR23 deficiency exacerbates hepatic steatosis in mice., [RefSeq, PubMed]; Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil (PubMed:10097159, PubMed:25791473, PubMed:28842679). Its activation increases intracellular Ca(2+) (PubMed:10097159, PubMed:15522887, PubMed:25791473, PubMed:28842679). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (PubMed:19922870). Also acts as a regulator of angiogenesis (PubMed:25791473). Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679). Involved in sperm chemotaxis and motility (PubMed:15522887)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0055088 lipid homeostasis;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62007-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q792Z0-1", "uniprot_id": "Q792Z0_MOUSE", "mass": 26184.0, "length": 246, "protein_name": "trypsin", "gene_name": "Prss3", "organism": "Mouse", "refseq_name": "mesotrypsin precursor", "refseq_ac": "NP_035775", "gene_names_uniprotkb": "Prss3", "gene_names_refseq": "MTG; Prss3; TRY4; Tb; Try3", "protein_names_uniprotkb": "trypsin; 3.4.21.4", "protein_names_refseq": "mesotrypsin precursor; protease, serine 3; trypsin 3; trypsinogen 15", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:22073); (R-MMU-1462054); (R-MMU-1592389); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "17087933;17363470;21750661;24872419", "class_list": "", "function": "Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models., [RefSeq, PubMed]; The initiation of acute pancreatitis depends on endocytic vacuole formation and trypsinogen activation in pancreatic acinar cells, [RefSeq, PubMed]; These results underscore the importance of trypsinogen PRSS1 mutations as pathogenic mediators of hereditary pancreatitis and indicate that persistent pancreatic injury might be causally linked to chronic pancreatitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.22;3.4.24.34;3.4.22.27;1.1.1.42;4.1.2.13;3.4.21.4;3.4.21.-;3.2.1.17;1.16.3.1;3.4.23.5;3.4.21.39;3.4.21.59;3.3.2.6;3.4.11.4;3.4.21.34;3.4.21.20;3.4.24.17;3.1.3.48;3.4.24.-;3.4.24.35;3.5.4.5;3.4.24.23;3.4.21.37;1.8.3.2;3.6.1.6;3.4.21.1;2.3.2.5;5.4.2.2;3.2.1.14;3.4.24.7;3.5.1.3;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q792Z0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TRQ1-1", "uniprot_id": "Q7TRQ1_MOUSE", "mass": 35498.0, "length": 315, "protein_name": "Olfactory receptor family 51 subfamily A member 24", "gene_name": "Or51a24", "organism": "Mouse", "refseq_name": "olfactory receptor family 51 subfamily A member 24", "refseq_ac": "NP_997027", "gene_names_uniprotkb": "Or51a24; Olfr645", "gene_names_refseq": "MOR13-5; Olfr645; Or51a24", "protein_names_uniprotkb": "Olfactory receptor family 51 subfamily A member 24", "protein_names_refseq": "GA_x6K02T2PBJ9-6819097-6818150; olfactory receptor 645; olfactory receptor MOR13-5; olfactory receptor family 51 subfamily A member 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:258247)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TRQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TS33-1", "uniprot_id": "Q7TS33_MOUSE", "mass": 36835.0, "length": 327, "protein_name": "Olfactory receptor family 6 subfamily D member 12", "gene_name": "Or6d12", "organism": "Mouse", "refseq_name": "olfactory receptor 212", "refseq_ac": "NP_001011800", "gene_names_uniprotkb": "Or6d12; Olfr212", "gene_names_refseq": "4931403F16Rik; MOR119-4; Olfr212; Or6d12", "protein_names_uniprotkb": "Olfactory receptor family 6 subfamily D member 12", "protein_names_refseq": "GA_x54KRFPKN04-58149882-58150865; olfactory receptor 212; olfactory receptor MOR119-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:258019)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TS33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPK2-1", "uniprot_id": "ZCHC3_MOUSE", "mass": 43771.0, "length": 400, "protein_name": "Zinc finger CCHC domain-containing protein 3", "gene_name": "Zcchc3", "organism": "Mouse", "refseq_name": "zinc finger CCHC domain-containing protein 3", "refseq_ac": "NP_780335", "gene_names_uniprotkb": "Zcchc3", "gene_names_refseq": "2810406K24Rik; Zcchc3", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 3", "protein_names_refseq": "zinc finger CCHC domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67917)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30135424;30193849;32133501", "class_list": "", "function": "Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30135424, PubMed:30193849). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30135424, PubMed:30193849). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (By similarity). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (By similarity). Promotes sensing of viral RNA by RIG-I-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This study shows that the Zinc-Finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors, [RefSeq, PubMed]; ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response Erratum:[Nat Commun. 2021 Sep 14;12(1):5526. doi: 10.1038/s41467-021-25397-7. PMID: 34521835] Publication Status: Online-Only, [RefSeq, PubMed]; ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:1900246 positive regulation of RIG-I signaling pathway;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BPK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUN9-1", "uniprot_id": "NCKX2_MOUSE", "mass": 74241.0, "length": 666, "protein_name": "Sodium/potassium/calcium exchanger 2", "gene_name": "Slc24a2", "organism": "Mouse", "refseq_name": "sodium/potassium/calcium exchanger 2 isoform 2", "refseq_ac": "NP_001103710", "gene_names_uniprotkb": "Slc24a2", "gene_names_refseq": "2810021B17Rik; 6330417K15Rik; Nckx2; Slc24a2", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 2; Na(+)/K(+)/Ca(2+)-exchange protein 2; Retinal cone Na-Ca+K exchanger; Solute carrier family 24 member 2", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 2; retinal cone Na-Ca+K exchanger; sodium/potassium/calcium exchanger 2 isoform 2; sodium/potassium/calcium exchanger 2; solute carrier family 24 member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76376); (R-MMU-425561)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16407245;18166528;18305240;21750661;24129315;9461611", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (PubMed:16407245)., [UniProtKB, PubMed, UniProtKB]; Mouse ortholog of rat Slc24a2 solute carrier family 24, encoding a potassium-dependent sodium-calcium exchanger (partial cds), [RefSeq, PubMed]; NCKX2 is involved in brain ischemia, and it may represent a new potential target to be investigated in the study of the molecular mechanisms involved in cerebral ischemia., [RefSeq, PubMed]; Non-synonymous single nucleotide polymorphism in SLC24A5 alters a residue that is important for NCKX5 and NCKX2 activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AXF2;B1AXF3;Q14AY1;Q14BI1", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098794 postsynapse;GO:0098793 presynapse", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BUN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VG49-1", "uniprot_id": "Q8VG49_MOUSE", "mass": 35285.0, "length": 315, "protein_name": "Olfactory receptor family 2 subfamily D member 2", "gene_name": "Or2d2", "organism": "Mouse", "refseq_name": "olfactory receptor 715", "refseq_ac": "NP_666991", "gene_names_uniprotkb": "Or2d2; Olfr715", "gene_names_refseq": "MOR260-1; Olfr715; Or2d2", "protein_names_uniprotkb": "Olfactory receptor family 2 subfamily D member 2", "protein_names_refseq": "B2 olfactory receptor; GA_x6K02T2PBJ9-9479517-9478573; olfactory receptor 715; olfactory receptor MOR260-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258776)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z4S1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VG49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "W4VSP6-1", "uniprot_id": "W4VSP6_MOUSE", "mass": 46010.0, "length": 401, "protein_name": "AADACL2 family member 2", "gene_name": "Aadacl2fm2", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC433597", "refseq_ac": "NP_001095001", "gene_names_uniprotkb": "Aadacl2fm2; Gm5538", "gene_names_refseq": "433597; Aadacl2fm2; Gm5538", "protein_names_uniprotkb": "AADACL2 family member 2", "protein_names_refseq": "uncharacterized protein LOC433597", "tax_id": 10090, "disease": "", "pathway": " (mmu:433597)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "W4VSP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJY3-1", "uniprot_id": "NSMA2_MOUSE", "mass": 71197.0, "length": 655, "protein_name": "Sphingomyelin phosphodiesterase 3", "gene_name": "Smpd3", "organism": "Mouse", "refseq_name": "sphingomyelin phosphodiesterase 3", "refseq_ac": "NP_067466", "gene_names_uniprotkb": "Smpd3", "gene_names_refseq": "4631433G07Rik; Nsm2; Smpd3; fro; nSMase2", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 3; 3.1.4.12; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSMase-2; nSMase2", "protein_names_refseq": "nSMase-2; neutral sphingomyelinase 2; neutral sphingomyelinase II; sphingomyelin phosphodiesterase 3", "tax_id": 10090, "disease": "osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); osteogenesis imperfecta (Disease Ontology:DOID:12347); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary hypertension (Disease Ontology:DOID:6432); hypopituitarism (Disease Ontology:DOID:9406); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:58994); (R-MMU-5626978); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10823942;12566438;15051724;15764706;15929065;16025116;17272284;21183079;21550973;39171374", "class_list": "glycogene", "function": "Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:15051724, PubMed:15764706, PubMed:15929065, PubMed:16025116). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (PubMed:21550973). May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Transcriptomics analysis reveals potential regulatory role of nSMase2 (Smpd3) in nervous system development and function of middle-aged mouse brains., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 44, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTQ5", "ec_number_list": "3.1.4.12;3.1.4.3;3.1.4.38;3.1.4.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0001786 phosphatidylserine binding;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0097187 dentinogenesis;GO:0071461 cellular response to redox state;GO:0085029 extracellular matrix assembly;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JJY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54943-1", "uniprot_id": "PER2_MOUSE", "mass": 135881.0, "length": 1257, "protein_name": "Period circadian protein homolog 2", "gene_name": "Per2", "organism": "Mouse", "refseq_name": "period circadian protein homolog 2 isoform 1", "refseq_ac": "NP_035196", "gene_names_uniprotkb": "Per2", "gene_names_refseq": "Per2; mKIAA0347; mPer2", "protein_names_uniprotkb": "Period circadian protein homolog 2; Circadian clock protein PERIOD 2; mPER2", "protein_names_refseq": "circadian clock protein PERIOD 2; period 2; period circadian protein homolog 2 isoform 1; period circadian protein homolog 2; period homolog 2", "tax_id": 10090, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); advanced sleep phase syndrome 1 (Disease Ontology:DOID:0110011); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:18627); (R-MMU-9932298)", "pathway_count": 2, "publication_count": 62, "publication_id_list": "10428031;10848614;11395012;11591712;11779462;11865049;11889036;14701732;15860628;16097765;16478995;16595674;16717091;16983144;17242355;17274955;17310242;17404161;18419266;18662546;18782782;19402751;19414593;19605937;19917250;20159955;20840750;21035761;21183079;21613214;21680841;21712997;21750661;21768648;21930935;22208286;22274616;22504074;22767893;22966205;23079727;23303907;23418588;23531614;23916625;23977055;24154698;24385426;24413057;24603368;26279567;28011936;29784789;29937374;30084848;30779550;30782483;31219806;34428180;9427249;9428527;9856465", "class_list": "", "function": "This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O54954", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070345 negative regulation of fat cell proliferation;GO:0060567 negative regulation of termination of DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 6.3, "record_id": "O54943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1W2P6Q9-1", "uniprot_id": "A0A1W2P6Q9_MOUSE", "mass": 15297.0, "length": 132, "protein_name": "Anaphase promoting complex C subunit 15, pseudogene", "gene_name": "Anapc15-ps", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Anapc15-ps", "gene_names_refseq": "", "protein_names_uniprotkb": "Anaphase promoting complex C subunit 15, pseudogene", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P6Q9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X9B4-1", "uniprot_id": "G3X9B4_MOUSE", "mass": 30759.0, "length": 273, "protein_name": "BRD8 domain containing", "gene_name": "Brd8dc", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC271508 isoform 1", "refseq_ac": "NP_808441", "gene_names_uniprotkb": "Brd8dc; 4933408B17Rik", "gene_names_refseq": "4933408B17Rik; Brd8dc", "protein_names_uniprotkb": "BRD8 domain containing", "protein_names_refseq": "uncharacterized protein LOC271508 isoform 1", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X9B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A065-1", "uniprot_id": "CE170_MOUSE", "mass": 175050.0, "length": 1588, "protein_name": "Centrosomal protein of 170 kDa", "gene_name": "Cep170", "organism": "Mouse", "refseq_name": "centrosomal protein of 170 kDa isoform X1", "refseq_ac": "XP_006497000", "gene_names_uniprotkb": "Cep170; Kiaa0470", "gene_names_refseq": "4933426L22Rik; A330004A13Rik; Cep170", "protein_names_uniprotkb": "Centrosomal protein of 170 kDa; Cep170", "protein_names_refseq": "centrosomal protein of 170 kDa isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545389)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;16452087;19131326;19144319;21183079;21750661;22645316;22872234;23386061;25428506;27565344;28528544;29742020;30084848;32848054;33300544;34203471;34428180;34678516;40021952;40885482", "class_list": "", "function": "Plays a role in microtubule organization. Required for centriole subdistal appendage assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQD9;Q8BJW2;Q9D3Z0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005814 centriole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q6A065-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F6QVC4-1", "uniprot_id": "F6QVC4_MOUSE", "mass": 23870.0, "length": 198, "protein_name": "RIKEN cDNA 1700049E17 gene, gene 1; Tandem duplication of RIKEN cDNA 1700049E17 gene, gene 2", "gene_name": "1700049E17Rik1; 1700049E17Rik2", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC666214", "refseq_ac": "NP_001344967", "gene_names_uniprotkb": "1700049E17Rik1; 1700049E17Rik2; 1700049E17Rik2", "gene_names_refseq": "1700049E17Rik1; 1700049E17Rik; 666214", "protein_names_uniprotkb": "RIKEN cDNA 1700049E17 gene, gene 1; Tandem duplication of RIKEN cDNA 1700049E17 gene, gene 2", "protein_names_refseq": "uncharacterized protein LOC666214", "tax_id": 10090, "disease": "", "pathway": " (mmu:666214)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q8F7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6QVC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62120-1", "uniprot_id": "JAK2_MOUSE", "mass": 130595.0, "length": 1132, "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "Jak2", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase JAK2", "refseq_ac": "NP_001041642", "gene_names_uniprotkb": "Jak2", "gene_names_refseq": "Fd17; Jak2", "protein_names_uniprotkb": "Tyrosine-protein kinase JAK2; 2.7.10.2; JAK-2; Janus kinase 2", "protein_names_refseq": "JAK-2; tyrosine-protein kinase JAK2", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); familial erythrocytosis 1 (Disease Ontology:DOID:0060652); thrombosis (Disease Ontology:DOID:0060903); myeloid neoplasm (Disease Ontology:DOID:0070004); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); stomach cancer (Disease Ontology:DOID:10534); portal hypertension (Disease Ontology:DOID:10762); esophageal carcinoma (Disease Ontology:DOID:1107); heart disease (Disease Ontology:DOID:114); Budd-Chiari syndrome (Disease Ontology:DOID:11512); primary biliary cholangitis (Disease Ontology:DOID:12236); leukemia (Disease Ontology:DOID:1240); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); disease of cellular proliferation (Disease Ontology:DOID:14566); limited scleroderma (Disease Ontology:DOID:1577); cancer (Disease Ontology:DOID:162); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); colon cancer (Disease Ontology:DOID:219); essential thrombocythemia (Disease Ontology:DOID:2224); myeloproliferative neoplasm (Disease Ontology:DOID:2226); thrombocytosis (Disease Ontology:DOID:2228); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); hematologic cancer (Disease Ontology:DOID:2531); liver cancer (Disease Ontology:DOID:3571); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); bacterial gastritis (Disease Ontology:DOID:4033); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); polycythemia vera (Disease Ontology:DOID:8997); acute myeloid leukemia (Disease Ontology:DOID:9119); nasopharynx carcinoma (Disease Ontology:DOID:9261); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16452); (R-MMU-1059683); (R-MMU-110056); (R-MMU-112411); (R-MMU-1170546); (R-MMU-1433557); (R-MMU-512988); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-6785807); (R-MMU-6788467); (R-MMU-69231); (R-MMU-877300); (R-MMU-877312); (R-MMU-8854691); (R-MMU-8984722); (R-MMU-9006335); (R-MMU-9020591); (R-MMU-9020933); (R-MMU-9020956); (R-MMU-9027276); (R-MMU-9027284); (R-MMU-912526); (R-MMU-9674555); (R-MMU-9705462); (R-MMU-9732724); (R-MMU-982772); (R-MMU-983231); (R-MMU-9958825)", "pathway_count": 29, "publication_count": 50, "publication_id_list": "10.1101/2023.09.13.557529;10064597;10842184;11779507;11923481;15121872;16705160;16824542;16914724;17024180;17027227;17208428;17404288;17565041;17849321;19144319;20068132;20098430;20304997;21183079;21368206;21423214;21726629;21750661;24251790;2466296;2482828;26788034;26799659;26949510;27977755;28100634;28912580;30070632;31255914;31943454;32943679;33413536;34203471;34428180;36210013;7775438;8272873;8343951;8378315;8702638;9473212;9573010;9590173;9590174", "class_list": "", "function": "Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Functionnally, plays a pivotal role in signal transduction and is involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Up-regulates the potassium voltage-gated channel activity of KCNA3 (By similarity). Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking proteins for STAT3 (By similarity). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 44, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G5E852;Q62124;Q7TQD0", "ec_number_list": "2.7.12.2;2.7.10.1;3.2.1.31;2.7.12.1;2.7.1.153;2.7.1.137;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.11;3.6.5.2;2.7.11.17;3.1.3.48;2.3.2.27;2.7.11.13;2.7.11.22;2.7.10.4;2.7.1.40;2.3.2.24;2.3.2.23;2.3.2.32;2.7.11.24;2.7.11.23;3.1.4.11;3.1.3.86;3.1.3.56;3.1.3.36;2.7.1.154", "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0045063 T-helper 1 cell differentiation;GO:0051142 positive regulation of NK T cell proliferation;GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0060399 positive regulation of growth hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "Q62120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC10-1", "uniprot_id": "OSGI1_MOUSE", "mass": 52170.0, "length": 478, "protein_name": "Oxidative stress-induced growth inhibitor 1", "gene_name": "Osgin1", "organism": "Mouse", "refseq_name": "oxidative stress-induced growth inhibitor 1", "refseq_ac": "NP_082226", "gene_names_uniprotkb": "Osgin1", "gene_names_refseq": "1700012B18Rik; Okl38; Osgin1", "protein_names_uniprotkb": "Oxidative stress-induced growth inhibitor 1; 1.14.13.-", "protein_names_refseq": "oxidative stress-induced growth inhibitor 1; pregnancy-induced growth inhibitor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71839)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Monooxygenase catalytic activity (By similarity). Involved in regulation of cytokinesis; promotes RHOA activity, probably acting locally at the midbody in late cytokinesis (By similarity). Monooxygenase activity is involved in stabilizing transient structures between daughter cells, termed intercellular bridges, before abscission (By similarity). Regulates differentiation and proliferation through the regulation of cell death (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0030496 midbody", "go_biological_process": "GO:0030154 cell differentiation;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VC10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AGD7-1", "uniprot_id": "A2AGD7_MOUSE", "mass": 37096.0, "length": 326, "protein_name": "Coiled-coil domain containing 163", "gene_name": "Ccdc163", "organism": "Mouse", "refseq_name": "transmembrane protein CCDC163 isoform 2", "refseq_ac": "NP_080990", "gene_names_uniprotkb": "Ccdc163", "gene_names_refseq": "0610037D15Rik; 4933430J04Rik; Ccdc163", "protein_names_uniprotkb": "Coiled-coil domain containing 163", "protein_names_refseq": "transmembrane protein CCDC163 isoform 2", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AGD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PUQ3-1", "uniprot_id": "E9PUQ3_MOUSE", "mass": 33955.0, "length": 292, "protein_name": "NKAP domain containing 1", "gene_name": "Nkapd1", "organism": "Mouse", "refseq_name": "uncharacterized protein NKAPD1 isoform 1", "refseq_ac": "NP_001128374", "gene_names_uniprotkb": "Nkapd1", "gene_names_refseq": "Ahed; Gm639; Nkapd1", "protein_names_uniprotkb": "NKAP domain containing 1", "protein_names_refseq": "uncharacterized protein NKAPD1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:270156)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PUQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1ATX6-1", "uniprot_id": "B1ATX6_MOUSE", "mass": 44704.0, "length": 390, "protein_name": "polynucleotide adenylyltransferase", "gene_name": "Tent5d", "organism": "Mouse", "refseq_name": "terminal nucleotidyltransferase 5D", "refseq_ac": "NP_001156576", "gene_names_uniprotkb": "Tent5d; Fam46d", "gene_names_refseq": "Fam46d; Gm377; Tent5d", "protein_names_uniprotkb": "polynucleotide adenylyltransferase; 2.7.7.19", "protein_names_refseq": "family with sequence similarity 46, member D; terminal nucleotidyltransferase 5D", "tax_id": 10090, "disease": "", "pathway": " (mmu:213449)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "", "go_biological_process": "GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1ATX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AR13-1", "uniprot_id": "CISD3_MOUSE", "mass": 15676.0, "length": 137, "protein_name": "CDGSH iron-sulfur domain-containing protein 3, mitochondrial", "gene_name": "Cisd3", "organism": "Mouse", "refseq_name": "CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 2 precursor", "refseq_ac": "NP_001078969", "gene_names_uniprotkb": "Cisd3; Mel-13; Mel13", "gene_names_refseq": "Cisd3; Mel-13; Mel13", "protein_names_uniprotkb": "CDGSH iron-sulfur domain-containing protein 3, mitochondrial; Melanoma nuclear protein 13", "protein_names_refseq": "CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 2 precursor; CDGSH iron-sulfur domain-containing protein 3, mitochondrial; melanoma nuclear protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:217149)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;23576753;23806337;34428180;36702076;37507081;8597592", "class_list": "", "function": "Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function., [UniProtKB, UniProtKB]; FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AR11;B1AR12", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B1AR13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F8VQ05-1", "uniprot_id": "F8VQ05_MOUSE", "mass": 337819.0, "length": 3007, "protein_name": "FRY like transcription coactivator", "gene_name": "Fryl", "organism": "Mouse", "refseq_name": "protein furry homolog-like", "refseq_ac": "NP_082470", "gene_names_uniprotkb": "Fryl", "gene_names_refseq": "2010313D22Rik; 2310004H21Rik; 2510002A14Rik; 9030227G01Rik; Fryl; mKIAA0826", "protein_names_uniprotkb": "FRY like transcription coactivator", "protein_names_refseq": "furry homolog-like; protein furry homolog-like", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); Pan-Chung-Bellen syndrome (Disease Ontology:DOID:0061146)", "pathway": " (mmu:72313)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21750661;29409347", "class_list": "", "function": "Fryl protein is required for normal development and functional maintenance of kidney in mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005938 cell cortex;GO:0030427 site of polarized growth", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F8VQ05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AUP5-1", "uniprot_id": "A2AUP5_MOUSE", "mass": 58967.0, "length": 514, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3", "gene_name": "Pfkfb3", "organism": "Mouse", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 3", "refseq_ac": "NP_001171225", "gene_names_uniprotkb": "Pfkfb3", "gene_names_refseq": "E330010H22Rik; Pfkfb3; iPFK-2; uPFK-2", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 3; inducible 6-phosphofructo-2-kinase", "tax_id": 10090, "disease": "extrinsic cardiomyopathy (Disease Ontology:DOID:3978)", "pathway": " (R-MMU-9634600)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15845370;17242355;18710022;21750661;39096131;39433564", "class_list": "glycogene", "function": "Hypoxia activates macrophage-NLRP3 inflammasome promoting atherosclerosis via PFKFB3-driven glycolysis., [RefSeq, PubMed]; Inducible 6-phosphofructo-2-kinase expression is essential for the survival of the growing embryo., [RefSeq, PubMed]; PFKFB3 ameliorates ischemia-induced neuronal damage by reducing reactive oxygen species and inhibiting nuclear translocation of Cdk5. Publication Status: Online-Only, [RefSeq, PubMed]; Possible role of PFKFB-3 splice isoform in cell adaptation to hypoxic conditions., [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7UAK6", "ec_number_list": "", "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process;GO:0006915 apoptotic process;GO:0006096 glycolytic process;GO:0010001 glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AUP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2Z1-1", "uniprot_id": "CEA20_MOUSE", "mass": 63444.0, "length": 577, "protein_name": "Cell adhesion molecule CEACAM20", "gene_name": "Ceacam20", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM20 precursor", "refseq_ac": "NP_082115", "gene_names_uniprotkb": "Ceacam20", "gene_names_refseq": "9130012D09Rik; Ceacam20", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM20; CEA cell adhesion molecule 20; Carcinoembryonic antigen-related cell adhesion molecule 20", "protein_names_refseq": "CEA-related cell adhesion molecule 20; carcinoembryonic antigen-related cell adhesion molecule 20; cell adhesion molecule CEACAM20 precursor; cell adhesion molecule CEACAM20", "tax_id": 10090, "disease": "", "pathway": " (mmu:71601)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16139472;21750661;25908210;26195794;31616917", "class_list": "", "function": "Gram-positive bacteria promote the mRNA expression of CEACAM1 or CEACAM20 in the small intestine. Inflammatory cytokines or butyrate likely participates in such effects of commensal bacteria., [RefSeq, PubMed]; SAP-1 and CEACAM20 thus constitute a regulatory system through which the intestinal epithelium contributes to intestinal immunity., [RefSeq, PubMed]; Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y42", "ec_number_list": "", "go_molecular_function": "GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0009617 response to bacterium;GO:0001819 positive regulation of cytokine production;GO:0002682 regulation of immune system process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D2Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJA9-1", "uniprot_id": "AJM1_MOUSE", "mass": 107186.0, "length": 974, "protein_name": "Apical junction component 1 homolog", "gene_name": "Ajm1", "organism": "Mouse", "refseq_name": "apical junction component 1 homolog", "refseq_ac": "NP_001005424", "gene_names_uniprotkb": "Ajm1; Gm996", "gene_names_refseq": "Ajm1; Gm996", "protein_names_uniprotkb": "Apical junction component 1 homolog", "protein_names_refseq": "Uncharacterized protein C9orf172 homolog; apical junction component 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:381353)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16452087;17114649;21183079;21750661;22645316;24129315;32848054;33300544;34428180;34678516;35820727;40021952;40885482", "class_list": "", "function": "May be involved in the control of adherens junction integrity., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0A3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005929 cilium;GO:0016324 apical plasma membrane;GO:0043296 apical junction complex", "go_biological_process": "GO:0045216 cell-cell junction organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "A2AJA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924A2-4", "uniprot_id": "CIC_MOUSE", "mass": 258130.0, "length": 2510, "protein_name": "Protein capicua homolog", "gene_name": "Cic", "organism": "Mouse", "refseq_name": "protein capicua homolog isoform CIC-L", "refseq_ac": "NP_001289740", "gene_names_uniprotkb": "Cic; Kiaa0306", "gene_names_refseq": "1200010B10Rik; Cic; mKIAA0306", "protein_names_uniprotkb": "Protein capicua homolog", "protein_names_refseq": "protein capicua homolog isoform CIC-L; protein capicua homolog", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 45 (Disease Ontology:DOID:0080236); disease of mental health (Disease Ontology:DOID:150)", "pathway": " (mmu:71722)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.3389/fragi.2021.757801;12393275;15981098;17190598;17242355;17322884;21183079;23806337;24129315;28288114;32782141;32848054;36852467;40997131", "class_list": "", "function": "Results describe the identification and characterization of a new gene, Cic, in both human and mouse genomes, that is implicated in granule cell development., [RefSeq, PubMed]; Transcriptional repressor which plays a role in development of the central nervous system (CNS) (PubMed:17190598). In concert with ATXN1 and ATXN1L, involved in brain development (PubMed:28288114)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 0, "predicted_o_glycosites": 17, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 33, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH79;Q3UHP4;Q6PDJ8;Q8CGE4;Q8CHH0;Q9CW61", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q924A2-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUD1-1", "uniprot_id": "CHIP_MOUSE", "mass": 34909.0, "length": 304, "protein_name": "E3 ubiquitin-protein ligase CHIP", "gene_name": "Stub1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase CHIP", "refseq_ac": "NP_062693", "gene_names_uniprotkb": "Stub1; Chip", "gene_names_refseq": "0610033N24Rik; 2210017D18Rik; 2310040B03Rik; Chip; Stub1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CHIP; 2.3.2.27; Carboxy terminus of Hsp70-interacting protein; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase CHIP; RING-type E3 ubiquitin transferase CHIP; carboxy terminus of Hsp70-interacting protein", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 16 (Disease Ontology:DOID:0080029); cerebellar ataxia type 48 (Disease Ontology:DOID:0111746); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:56424); (R-MMU-2173788); (R-MMU-5357905); (R-MMU-5675482); (R-MMU-8863795); (R-MMU-8939902); (R-MMU-8948751); (R-MMU-983168)", "pathway_count": 8, "publication_count": 29, "publication_id_list": "10330192;11435423;12150907;14507928;16307917;16452087;19131326;19144319;19237536;20060297;20724525;21183079;21750661;21855799;22645316;23973223;24043303;26265139;26495903;28528544;29934347;31219806;35710596;37213079;37828378;38310161;38471267;39059559;39322015", "class_list": "", "function": "CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation., [RefSeq, PubMed]; CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity., [RefSeq, PubMed]; CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:11435423, PubMed:21855799, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (PubMed:29934347). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (By similarity). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (By similarity). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (By similarity). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:11435423, PubMed:21855799). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (By similarity). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (By similarity). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (By similarity). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (By similarity). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (By similarity). Mediates polyubiquitination of CYP3A4 (By similarity). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (By similarity). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (By similarity). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (By similarity). Plays a role in the degradation of TP53 (By similarity). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (By similarity). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (PubMed:35710596)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results demonstrate a novel co-chaperone(CHIP)-dependent mechanism through which eNOS trafficking is regulated and suggest a potentially generalized role for CHIP in protein trafficking through the Golgi compartment, [RefSeq, PubMed]; STUB1 increases adiponectin expression by inducing ubiquitination and degradation of NR2F2, thereby reducing hepatic stellate cell activation and alleviating non-alcoholic fatty liver disease., [RefSeq, PubMed]; Staphylococcus aureus infection initiates hypoxia-mediated STIP1 homology and U-box containing protein 1 upregulation to trigger osteomyelitis., [RefSeq, PubMed]; Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCJ0", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.6.4.10;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.10.1;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0030911 TPR domain binding;GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0031943 regulation of glucocorticoid metabolic process;GO:0090035 positive regulation of chaperone-mediated protein complex assembly;GO:0061684 chaperone-mediated autophagy;GO:1901526 positive regulation of mitophagy;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9WUD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E0CZ26-1", "uniprot_id": "E0CZ26_MOUSE", "mass": 46973.0, "length": 429, "protein_name": "Potassium channel tetramerisation domain containing 18", "gene_name": "Kctd18", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kctd18", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium channel tetramerisation domain containing 18", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:51960)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30779550", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E0CZ26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PUZ0-1", "uniprot_id": "E9PUZ0_MOUSE", "mass": 37405.0, "length": 337, "protein_name": "Apolipoprotein L 11b", "gene_name": "Apol11b", "organism": "Mouse", "refseq_name": "apolipoprotein L 11b", "refseq_ac": "NP_001137158", "gene_names_uniprotkb": "Apol11b", "gene_names_refseq": "A330102K04Rik; Apol11b", "protein_names_uniprotkb": "Apolipoprotein L 11b", "protein_names_refseq": "apolipoprotein L 11b", "tax_id": 10090, "disease": "substance abuse (Disease Ontology:DOID:302); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:328563); (R-MMU-2168880); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PUZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A087WRK1-1", "uniprot_id": "A0A087WRK1_MOUSE", "mass": 25620.0, "length": 222, "protein_name": "Predicted gene, 20814; Predicted gene, 20855; Predicted gene, 20905; Predicted gene, 20906; Predicted gene, 20908; Predicted gene, 20920; Predicted gene, 20931; Predicted gene, 21317; Predicted gene, 21366; Sycp3 like Y-linked", "gene_name": "Gm20894; Gm20905; Gm21409; Sly", "organism": "Mouse", "refseq_name": "Sycp3 like Y-linked", "refseq_ac": "NP_963288", "gene_names_uniprotkb": "Gm20894; Gm20905; Gm21409; Sly; Gm20814; Gm20835; Gm20850; Gm20855; Gm20869; Gm20870; Gm20883; Gm20894; Gm20896; Gm20897; Gm20903; Gm20906; Gm20908; Gm20916; Gm20920; Gm20929; Gm20931; Gm21317; Gm21366; Gm21409; Gm21477; Sly", "gene_names_refseq": "Sly", "protein_names_uniprotkb": "Predicted gene, 20814; Predicted gene, 20855; Predicted gene, 20905; Predicted gene, 20906; Predicted gene, 20908; Predicted gene, 20920; Predicted gene, 20931; Predicted gene, 21317; Predicted gene, 21366; Sycp3 like Y-linked", "protein_names_refseq": "Sycp3 like Y-linked", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176)", "pathway": " (mmu:100042201); (mmu:100042279); (mmu:108167378); (mmu:108168553); (mmu:108168555); (mmu:108168557); (mmu:108168558); (mmu:382301); (mmu:73329)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "19176879;19918361;21750661;23178944;28475176;32658962", "class_list": "", "function": "Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents., [RefSeq, PubMed]; Deficiency is responsible for the sperm DNA damage/chromatin packaging, [RefSeq, PubMed]; Expansion of sex-linked spermatid-expressed genes in mouse is a consequence of the enhancement of postmeiotic sex chromatin repression that accompanies Sly amplification, [RefSeq, PubMed]; SLY is a regulator of sperm chromatin remodeling. SMRT/N-CoR repressor complex is involved in gene regulation during sperm differentiation since members of this complex, in particular TBL1XR1, interact with SLY in postmeiotic male germ cells., [RefSeq, PubMed]; SLY1 interacts with acrosomal protein DKKL1, histone acetyltransferase KAT5 & microtubule-associated protein APPBP2; data suggest SLY1 may be involved in spermiogenesis processes, including control of gene expression & acrosome development or function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A087WRK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z338-1", "uniprot_id": "CTSRH_MOUSE", "mass": 13475.0, "length": 116, "protein_name": "Cation channel sperm-associated auxiliary subunit eta", "gene_name": "Catsperh; Tmem262", "organism": "Mouse", "refseq_name": "cation channel sperm-associated auxiliary subunit eta", "refseq_ac": "NP_001104787", "gene_names_uniprotkb": "Catsperh; Tmem262; BC048609; Tmem262", "gene_names_refseq": "Catsperh; Tmem262", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit eta; Cation channel sperm-associated auxiliary subunit TMEM262; Transmembrane protein 262", "protein_names_refseq": "cation channel sperm-associated auxiliary subunit TMEM262; cation channel sperm-associated auxiliary subunit eta; transmembrane protein 262", "tax_id": 10090, "disease": "", "pathway": " (mmu:433215)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34225353", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8U0-1", "uniprot_id": "IFRD2_MOUSE", "mass": 47717.0, "length": 441, "protein_name": "Interferon-related developmental regulator 2", "gene_name": "Ifrd2", "organism": "Mouse", "refseq_name": "interferon-related developmental regulator 2", "refseq_ac": "NP_080179", "gene_names_uniprotkb": "Ifrd2", "gene_names_refseq": "1810034A24Rik; Ifrd2; SKMc15", "protein_names_uniprotkb": "Interferon-related developmental regulator 2", "protein_names_refseq": "interferon-related developmental regulator 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15983)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;37603466", "class_list": "", "function": "Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation (By similarity). Associates with the P- and E-sites of the ribosome and inserts a C-terminal helix into the mRNA exit channel to preclude translation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15). Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSB3;Q9CW96", "ec_number_list": "", "go_molecular_function": "GO:0030371 translation repressor activity;GO:0043022 ribosome binding", "go_cellular_component": "", "go_biological_process": "GO:0006417 regulation of translation;GO:0060612 adipose tissue development;GO:0016055 Wnt signaling pathway;GO:0045444 fat cell differentiation;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D8U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0H4-1", "uniprot_id": "CELF2_MOUSE", "mass": 54271.0, "length": 508, "protein_name": "CUGBP Elav-like family member 2", "gene_name": "Celf2", "organism": "Mouse", "refseq_name": "CUGBP Elav-like family member 2 isoform 1", "refseq_ac": "NP_001103698", "gene_names_uniprotkb": "Celf2; Cugbp2; Napor", "gene_names_refseq": "B230218O03; B230345P09Rik; CELF-2; CUG-BP2; Celf2; Cugbp2; D230046B21Rik; Etr-3; Napor-2; Napor; mETR-3", "protein_names_uniprotkb": "CUGBP Elav-like family member 2; Bruno-like protein 3; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; ELAV-type RNA-binding protein 3; ETR-3; Neuroblastoma apoptosis-related RNA-binding protein; RNA-binding protein BRUNOL-3; mETR-3; mNapor", "protein_names_refseq": "CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; CUGBP Elav-like family member 2 isoform 1; RNA-binding protein BRUNOL-3; bruno-like protein 3; elav-type RNA-binding protein 3; mNapor; neuroblastoma apoptosis-related RNA-binding protein", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 97 (Disease Ontology:DOID:0070383)", "pathway": " (mmu:14007)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10524244;11158314;12022233;12535526;15358864;15830352;21750661;25428506;30084848;30779550;33725478;34428180;38514854;38664873;40997131;9887331", "class_list": "", "function": "Loss of RNA-binding protein CELF2 promotes acute leukemia development via FAT10-mTORC1., [RefSeq, PubMed]; MiR-208a-3p regulated by circUQCRC2 suppresses ischemia/reperfusion-induced acute kidney injury by inhibiting CELF2-mediated tubular epithelial cell apoptosis, inflammation and ferroptosis., [RefSeq, PubMed]; NAPOR may be one of a group of closely related proteins involved in splicing regulation within the brain., [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of several post-transcriptional events (PubMed:12022233). Involved in pre-mRNA alternative splicing, mRNA translation and stability (PubMed:12022233). Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (PubMed:12022233). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (By similarity). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exon 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (PubMed:12022233). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (PubMed:12535526). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5 (By similarity). Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs (By similarity). Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (PubMed:12535526). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (PubMed:12022233). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis (By similarity). Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AS10;A2AS11;A2AS15;Q3TNX4;Q3TTI4;Q3TUB8;Q3U668;Q3U7J8;Q3U9F2;Q3UVH4;Q9R0B2;Q9Z187", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090543 Flemming body;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006376 mRNA splice site recognition;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0016441 post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9Z0H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X9Z4-1", "uniprot_id": "PCF11_MOUSE", "mass": 172720.0, "length": 1553, "protein_name": "Pre-mRNA cleavage complex 2 protein Pcf11", "gene_name": "Pcf11", "organism": "Mouse", "refseq_name": "pre-mRNA cleavage complex 2 protein Pcf11", "refseq_ac": "NP_083354", "gene_names_uniprotkb": "Pcf11; KIAA0824", "gene_names_refseq": "2500001H09Rik; 5730417B17Rik; Pcf11", "protein_names_uniprotkb": "Pre-mRNA cleavage complex 2 protein Pcf11; Pre-mRNA cleavage complex II protein Pcf11", "protein_names_refseq": "cleavage and polyadenylation factor subunit homolog; pre-mRNA cleavage complex 2 protein Pcf11; pre-mRNA cleavage complex II protein Pcf11", "tax_id": 10090, "disease": "", "pathway": " (mmu:74737); (R-MMU-6807505); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "21750661;26495903;30840896;40997131", "class_list": "", "function": "Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II., [UniProtKB, UniProtKB]; PCF11 is autoregulated through a conserved IPA site, the removal of which leads to global activation of PASs close to gene promotors. Therefore, PCF11 uses distinct mechanisms to regulate genes of different sizes, and its autoregulation maintains homeostasis of PAS usage in the cell., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RX07;F6UFZ5;Q3TT32;Q3TTQ0;Q69ZY3;Q8K0S1;Q8R2P5;Q99KH9", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005849 mRNA cleavage factor complex", "go_biological_process": "GO:0006369 termination of RNA polymerase II transcription;GO:0031124 mRNA 3'-end processing;GO:0031440 regulation of mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G3X9Z4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53566-1", "uniprot_id": "CEBPA_MOUSE", "mass": 37430.0, "length": 359, "protein_name": "CCAAT/enhancer-binding protein alpha", "gene_name": "Cebpa", "organism": "Mouse", "refseq_name": "CCAAT/enhancer-binding protein alpha isoform c", "refseq_ac": "NP_001274443", "gene_names_uniprotkb": "Cebpa; Cebp", "gene_names_refseq": "C/ebpalpha; CBF-A; Cebpa; Cebp", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein alpha; C/EBP alpha", "protein_names_refseq": "C/EBP alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha isoform c", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:12606); (R-MMU-9616222)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "11672531;14660596;15107404;15509779;15589173;16537903;17090532;17290224;17627282;17890457;18408001;1935900;19587381;19641492;2006196;20075868;20516642;21602272;21750661;24367003;26450903;27373160;27923061;34428180;36228616;40997131;8090719;8415748;8798745", "class_list": "", "function": "Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation., [UniProtKB, UniProtKB]; This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014]., [RefSeq]; Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta (PubMed:15107404, PubMed:15589173, PubMed:36228616, PubMed:8415748). Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB (PubMed:15509779). Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP) (PubMed:24367003). Critical for the proper development of the liver and the lung (PubMed:8798745). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (PubMed:1935900, PubMed:8090719). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters (PubMed:11672531). Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1 (PubMed:17627282). To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2 (PubMed:17290224). In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (PubMed:17090532)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91XB6", "ec_number_list": "", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0036488 CHOP-C/EBP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0030851 granulocyte differentiation;GO:0043032 positive regulation of macrophage activation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P53566-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z0M9-1", "uniprot_id": "D3Z0M9_MOUSE", "mass": 95495.0, "length": 819, "protein_name": "Probable ATP-dependent RNA helicase DDX23", "gene_name": "Ddx23", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX23", "refseq_ac": "NP_001074450", "gene_names_uniprotkb": "Ddx23", "gene_names_refseq": "3110082M05Rik; 4921506D17Rik; Ddx23", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX23; 3.6.4.13; DEAD box protein 23", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; probable ATP-dependent RNA helicase DDX23", "tax_id": 10090, "disease": "", "pathway": " (mmu:74351); (R-MMU-72163); (R-MMU-72165)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;3.4.19.12;7.2.2.-;7.6.2.16;2.7.11.1;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;5.2.1.8", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0000785 chromatin", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0062176 R-loop processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z0M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ASI5-1", "uniprot_id": "SCN3A_MOUSE", "mass": 220880.0, "length": 1947, "protein_name": "Sodium channel protein type 3 subunit alpha", "gene_name": "Scn3a", "organism": "Mouse", "refseq_name": "sodium channel protein type 3 subunit alpha isoform 5", "refseq_ac": "NP_061202", "gene_names_uniprotkb": "Scn3a", "gene_names_refseq": "Gm1000; Nav1.3; Scn3a", "protein_names_uniprotkb": "Sodium channel protein type 3 subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein type III subunit alpha; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3", "protein_names_refseq": "sodium channel protein brain III subunit alpha; sodium channel protein type 3 subunit alpha isoform 5; sodium channel protein type 3 subunit alpha; sodium channel protein type III subunit alpha; sodium channel, voltage-gated, type III, alpha polypeptide; voltage-gated sodium channel subtype III; voltage-gated sodium channel subunit alpha Nav1.3", "tax_id": 10090, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy 62 (Disease Ontology:DOID:0080420); Dravet syndrome (Disease Ontology:DOID:0080422); familial focal epilepsy with variable foci 4 (Disease Ontology:DOID:0081424); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (mmu:20269)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25172946;25459751;25937544;29142310;30899004;33651884;38828629", "class_list": "", "function": "Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells., [RefSeq, PubMed]; Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:29142310). In some secretory cell types, it also participates in cell excitability through membrane depolarization and regulates cells responsiveness to stimuli triggering secretion. For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (PubMed:25172946, PubMed:29142310)., [UniProtKB, PubMed, PubMed]; SIRT1 mediates the excitability of spinal CaMKIIalpha-positive neurons and participates in neuropathic pain by controlling Nav1.3., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 7, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R5RP23;A0A0R5RP41", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005272 sodium channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0035725 sodium ion transmembrane transport;GO:0071236 cellular response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "A2ASI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGY1-1", "uniprot_id": "Q8VGY1_MOUSE", "mass": 35515.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "4930516K23Rik", "organism": "Mouse", "refseq_name": "olfactory receptor family 51 subfamily A member 42", "refseq_ac": "NP_667288", "gene_names_uniprotkb": "4930516K23Rik; Olfr643; Or51a42", "gene_names_refseq": "MOR13-2; Olfr643; Or51a42", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-6793628-6792684; olfactory receptor 643; olfactory receptor MOR13-2; olfactory receptor family 51 subfamily A member 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:259081)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X952-1", "uniprot_id": "G3X952_MOUSE", "mass": 110492.0, "length": 960, "protein_name": "Zinc finger with KRAB and SCAN domains 2", "gene_name": "Zkscan2", "organism": "Mouse", "refseq_name": "zinc finger protein with KRAB and SCAN domains 2", "refseq_ac": "NP_001074798", "gene_names_uniprotkb": "Zkscan2", "gene_names_refseq": "9430065N20Rik; Zfp694; Zkscan2", "protein_names_uniprotkb": "Zinc finger with KRAB and SCAN domains 2", "protein_names_refseq": "zinc finger protein 694; zinc finger protein with KRAB and SCAN domains 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:210162)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3X952-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VH16-1", "uniprot_id": "Q8VH16_MOUSE", "mass": 35711.0, "length": 318, "protein_name": "Olfactory receptor", "gene_name": "Or51a6", "organism": "Mouse", "refseq_name": "olfactory receptor 575", "refseq_ac": "NP_667325", "gene_names_uniprotkb": "Or51a6; Olfr575", "gene_names_refseq": "MOR8-1; Olfr575; Or51a6", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-5666843-5665908; olfactory receptor 575; olfactory receptor MOR8-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:259118)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071396 cellular response to lipid;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VH16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46414-1", "uniprot_id": "CDN1B_MOUSE", "mass": 22193.0, "length": 197, "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "Cdkn1b", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase inhibitor 1B", "refseq_ac": "NP_034005", "gene_names_uniprotkb": "Cdkn1b", "gene_names_refseq": "Cdkn1b; Kip1; p27Kip1; p27", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1", "protein_names_refseq": "cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor p27", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); myelodysplastic syndrome (Disease Ontology:DOID:0050908); multiple endocrine neoplasia type 4 (Disease Ontology:DOID:0080137); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); acute kidney failure (Disease Ontology:DOID:3021); multiple endocrine neoplasia (Disease Ontology:DOID:3125); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); infertility (Disease Ontology:DOID:5223); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12576); (R-MMU-187577); (R-MMU-198323); (R-MMU-2559582); (R-MMU-2559586); (R-MMU-6804116); (R-MMU-69202); (R-MMU-69231); (R-MMU-69563); (R-MMU-69656); (R-MMU-8849470); (R-MMU-9607240); (R-MMU-9634638)", "pathway_count": 13, "publication_count": 53, "publication_id_list": "10.1101/2023.09.13.557529;10086358;10811608;11565035;12093740;12856081;12972555;15010468;15075339;15528185;15546868;15579463;16229012;16391232;17242355;17726090;18299400;19204084;19224205;19584057;19648963;19767775;19966802;20146253;20173027;20228253;20505340;20837141;21194982;21571010;21885849;21952136;22014979;23707388;24806449;25583987;26344141;26528715;27181203;28295363;28522571;29927970;31219806;34203471;34428180;35820727;35984892;36210013;8033212;8033213;8534916;9192873;9399644", "class_list": "", "function": "Important regulator of cell cycle progression (PubMed:12972555, PubMed:8033213). Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes (PubMed:8033213). Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG74", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0001934 positive regulation of protein phosphorylation;GO:0007219 Notch signaling pathway;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "P46414-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VFX2-1", "uniprot_id": "CF157_MOUSE", "mass": 61048.0, "length": 523, "protein_name": "Cilia- and flagella-associated protein 157", "gene_name": "Cfap157", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 157", "refseq_ac": "NP_079895", "gene_names_uniprotkb": "Cfap157", "gene_names_refseq": "1700019L03Rik; Cfap157", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 157", "protein_names_refseq": "cilia- and flagella-associated protein 157", "tax_id": 10090, "disease": "", "pathway": " (mmu:227736)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17971504;27965440;35820727", "class_list": "", "function": "1700019L03Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Cfap157-deficient sperm exhibit axonemal loops, supernumerary axonemal profiles with ectopic accessory structures, excess cytoplasm and clustered mitochondria in the midpiece regions, and defective axonemes along the flagella., [RefSeq, PubMed]; Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility (PubMed:27965440). May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure (PubMed:27965440)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DA63", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0036064 ciliary basal body", "go_biological_process": "GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0VFX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4E9-1", "uniprot_id": "CDT1_MOUSE", "mass": 61510.0, "length": 557, "protein_name": "DNA replication factor Cdt1", "gene_name": "Cdt1", "organism": "Mouse", "refseq_name": "DNA replication factor Cdt1", "refseq_ac": "NP_080290", "gene_names_uniprotkb": "Cdt1; Ris2", "gene_names_refseq": "2610318F11Rik; Cdt1; DUP; Ris2", "protein_names_uniprotkb": "DNA replication factor Cdt1; DUP; Double parked homolog; Retroviral insertion site 2 protein", "protein_names_refseq": "DNA replication factor Cdt1; double parked homolog; retroviral insertion site 2 protein; retroviral integration site 1; retroviral integration site 2", "tax_id": 10090, "disease": "Meier-Gorlin syndrome 4 (Disease Ontology:DOID:0080515)", "pathway": " (mmu:67177); (R-MMU-68867); (R-MMU-68949); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11850834;12192004;14993212;15286659;15811859;36210634;36541916", "class_list": "", "function": "CDT1 drives replication overlicensing and enhances tumorigenesis in the gut[dagger]., [RefSeq, PubMed]; Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage., [RefSeq, PubMed]; Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity). Potential oncogene (PubMed:11850834)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUQ1;Q8BX29;Q8R3V0;Q8R4E8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000776 kinetochore", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0071163 DNA replication preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R4E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2C6-1", "uniprot_id": "Q8R2C6_MOUSE", "mass": 34582.0, "length": 297, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r21", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 21", "refseq_ac": "NP_598944", "gene_names_uniprotkb": "Vmn1r21", "gene_names_refseq": "V1rc28; Vmn1r21", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r21; vomeronasal 1 receptor 21; vomeronasal 1 receptor, C28; vomeronasal type 1 receptor C28", "tax_id": 10090, "disease": "", "pathway": " (mmu:171201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0N4SV70;A0A0N4SW70", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NV66-1", "uniprot_id": "ZN646_MOUSE", "mass": 196805.0, "length": 1788, "protein_name": "Zinc finger protein 646", "gene_name": "Zfp646", "organism": "Mouse", "refseq_name": "zinc finger protein 646", "refseq_ac": "NP_766337", "gene_names_uniprotkb": "Zfp646", "gene_names_refseq": "6820429M01; Zfp646", "protein_names_uniprotkb": "Zinc finger protein 646", "protein_names_refseq": "zinc finger protein 646", "tax_id": 10090, "disease": "", "pathway": " (mmu:233905)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;36210013", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NV66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0N4SUI7-1", "uniprot_id": "A0A0N4SUI7_MOUSE", "mass": 7026.0, "length": 68, "protein_name": "Negative regulator of P-body association", "gene_name": "Nbdy", "organism": "Mouse", "refseq_name": "T helper cell-induced peptide 5", "refseq_ac": "NP_001423324", "gene_names_uniprotkb": "Nbdy; 2210013O21Rik", "gene_names_refseq": "2210013O21Rik; Nbdy; Thp5", "protein_names_uniprotkb": "Negative regulator of P-body association", "protein_names_refseq": "T helper cell-induced peptide 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:70123)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22130674", "class_list": "", "function": "CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation., [RefSeq, PubMed]; The protein encoded by this gene is a 68 aa peptide produced by early activated CD4+ T cells. The encoded protein helps regulate the differentiation of these cells into T helper 2 (Th2) cells. [provided by RefSeq, Mar 2025]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0N4SUI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TR45-1", "uniprot_id": "Q7TR45_MOUSE", "mass": 35155.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or5w11", "organism": "Mouse", "refseq_name": "olfactory receptor 1131", "refseq_ac": "NP_666869", "gene_names_uniprotkb": "Or5w11; Olfr1131", "gene_names_refseq": "MOR177-4; Olfr1131; Or5w11", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-49133664-49134593; olfactory receptor 1131; olfactory receptor MOR177-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:258652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1SUI2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TR45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJQ7-1", "uniprot_id": "Q9JJQ7_MOUSE", "mass": 24758.0, "length": 215, "protein_name": "X-linked lymphocyte-regulated 4B", "gene_name": "Xlr4b", "organism": "Mouse", "refseq_name": "X-linked lymphocyte-regulated 4B", "refseq_ac": "NP_001280605", "gene_names_uniprotkb": "Xlr4b", "gene_names_refseq": "Xlr4b; Xlr4", "protein_names_uniprotkb": "X-linked lymphocyte-regulated 4B", "protein_names_refseq": "X-linked lymphocyte regulated gene 4; X-linked lymphocyte-regulated 4B", "tax_id": 10090, "disease": "", "pathway": " (mmu:27083)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0097061 dendritic spine organization;GO:0007286 spermatid development;GO:0042220 response to cocaine;GO:0051965 positive regulation of synapse assembly;GO:0061003 positive regulation of dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F8VQG7-1", "uniprot_id": "F8VQG7_MOUSE", "mass": 184700.0, "length": 1678, "protein_name": "NEDD4-binding protein 2-like 2", "gene_name": "N4bp2", "organism": "Mouse", "refseq_name": "NEDD4-binding protein 2", "refseq_ac": "NP_001020088", "gene_names_uniprotkb": "N4bp2", "gene_names_refseq": "B3bp; E430014I16; Gm1791; Gm868; N4bp2", "protein_names_uniprotkb": "NEDD4-binding protein 2-like 2; Phosphonoformate immuno-associated protein 5 homolog", "protein_names_refseq": "Bcl3 binding protein; NEDD4-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:333789)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;24129315;25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F8VQG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3XA30-1", "uniprot_id": "G3XA30_MOUSE", "mass": 43753.0, "length": 381, "protein_name": "Non-structural maintenance of chromosomes element 4", "gene_name": "Nsmce4a", "organism": "Mouse", "refseq_name": "non-structural maintenance of chromosomes element 4 homolog A", "refseq_ac": "NP_001156327", "gene_names_uniprotkb": "Nsmce4a", "gene_names_refseq": "2410003A14Rik; Nsmce4a", "protein_names_uniprotkb": "Non-structural maintenance of chromosomes element 4", "protein_names_refseq": "non-SMC element 4 homolog A; non-structural maintenance of chromosomes element 4 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67872); (R-MMU-3108214)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25428506;32384871", "class_list": "", "function": "Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids., [UniProtKB, UniProtKB]; Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3XA30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BFU4-1", "uniprot_id": "A2BFU4_MOUSE", "mass": 46596.0, "length": 402, "protein_name": "Predicted gene 14403", "gene_name": "Gm14403", "organism": "Mouse", "refseq_name": "predicted gene 14403", "refseq_ac": "NP_001423039", "gene_names_uniprotkb": "Gm14403", "gene_names_refseq": "Gm14403", "protein_names_uniprotkb": "Predicted gene 14403", "protein_names_refseq": "novel KRAB box and zinc finger, C2H2 type domain containing protein; predicted gene 14403", "tax_id": 10090, "disease": "", "pathway": " (mmu:433520)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BFU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AY64-1", "uniprot_id": "B1AY64_MOUSE", "mass": 19518.0, "length": 174, "protein_name": "Cysteine-rich perinuclear theca 3", "gene_name": "Cypt3", "organism": "Mouse", "refseq_name": "cysteine-rich perinuclear theca 3 isoform 1", "refseq_ac": "NP_001297645", "gene_names_uniprotkb": "Cypt3", "gene_names_refseq": "1700006H02Rik; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model. 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E330037C19; Mcc", "protein_names_uniprotkb": "Mutated in colorectal cancers", "protein_names_refseq": "colorectal mutant cancer protein isoform 2", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:328949)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21750661;25200342;30831321", "class_list": "", "function": "Loss of Mcc may promote cancer through a failure to repair inflammation-induced DNA damage., [RefSeq, PubMed]; Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0050680 negative regulation of epithelial cell proliferation;GO:0045184 establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "G3UW40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PV04-1", "uniprot_id": "E9PV04_MOUSE", "mass": 46854.0, "length": 411, "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "Eif4a3l1", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC668137", "refseq_ac": "NP_001136206", "gene_names_uniprotkb": "Eif4a3l1; Gm5576; Gm8994", "gene_names_refseq": "B020013A22Rik; EG668137; Eif4a3l1; Gm8994", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-III; 3.6.4.13; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3", "protein_names_refseq": "uncharacterized protein LOC668137", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:668137)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity;GO:0035368 selenocysteine insertion sequence binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:1904570 negative regulation of selenocysteine incorporation;GO:0006406 mRNA export from nucleus;GO:0010629 negative regulation of gene expression;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PV04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AVC7-1", "uniprot_id": "A2AVC7_MOUSE", "mass": 36561.0, "length": 325, "protein_name": "Olfactory receptor family 12 subfamily E member 10", "gene_name": "Or12e10", "organism": "Mouse", "refseq_name": "olfactory receptor 1145", "refseq_ac": "NP_666432", "gene_names_uniprotkb": "Or12e10; Olfr1145", "gene_names_refseq": "MOR264-19; Olfr1145; Or12e10", "protein_names_uniprotkb": "Olfactory receptor family 12 subfamily E member 10", "protein_names_refseq": "GA_x6K02T2Q125-49311440-49312384; olfactory receptor 1145; olfactory receptor MOR264-19", "tax_id": 10090, "disease": "", "pathway": " (mmu:258317)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AVC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62226-1", "uniprot_id": "SHH_MOUSE", "mass": 47773.0, "length": 437, "protein_name": "Sonic hedgehog protein", "gene_name": "Shh", "organism": "Mouse", "refseq_name": "sonic hedgehog protein isoform 1 precursor", "refseq_ac": "NP_033196", "gene_names_uniprotkb": "Shh; Hhg1", "gene_names_refseq": "9530036O11Rik; Dsh; HHG-1; Hhg1; Hxl3; Hx; M100081; ShhNC; Shh", "protein_names_uniprotkb": "Sonic hedgehog protein; 3.1.-.-; HHG-1; SHH; Shh N-terminal processed signaling domains; Shh unprocessed N-terminal signaling and C-terminal autoprocfretinaessing domains; ShhNC; ShhNp; Sonic hedgehog protein 19 kDa product", "protein_names_refseq": "hemimelic extra toes; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; short digits; sonic hedgehog protein isoform 1 precursor; sonic hedgehog protein", "tax_id": 10090, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly II (Disease Ontology:DOID:0060986); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); Parkinsonism (Disease Ontology:DOID:0080855); holoprosencephaly 3 (Disease Ontology:DOID:0110875); solitary median maxillary central incisor (Disease Ontology:DOID:0111380); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); membranous glomerulonephritis (Disease Ontology:DOID:10976); polydactyly (Disease Ontology:DOID:1148); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); biliary atresia (Disease Ontology:DOID:13608); hypothyroidism (Disease Ontology:DOID:1459); VACTERL association (Disease Ontology:DOID:14679); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); IgA glomerulonephritis (Disease Ontology:DOID:2986); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); holoprosencephaly (Disease Ontology:DOID:4621); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (mmu:20423); (R-MMU-5358346); (R-MMU-5362798); (R-MMU-5632681); (R-MMU-5635838)", "pathway_count": 5, "publication_count": 29, "publication_id_list": "11389830;11430830;11486055;12679031;14687547;15075292;15315762;16282375;18081866;18477453;18794898;19561611;20519495;21357747;22677548;22902404;23112049;23118222;24522195;24863049;29622726;31657721;33038332;7477329;7720571;7736596;7891723;7916661;8824192", "class_list": "glycogene", "function": "Precursor of sonic hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:11389830, PubMed:31657721, PubMed:7736596, PubMed:7891723, PubMed:8824192). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, Sonic hedgehog protein N-product and C-product (ShhN and ShhC, respectively) and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated ShhN (PubMed:7736596, PubMed:7891723, PubMed:8824192). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (PubMed:21357747). Following additional lipidation, ShhN acts as a morphogen, while ShhC is degraded in the endoplasmic reticulum (PubMed:21357747)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The dually lipidated sonic hedgehog protein N-product (ShhN) is a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:11389830, PubMed:14687547, PubMed:29622726, PubMed:7736596, PubMed:7916661). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (PubMed:31657721). In the absence of SHH, patched represses the constitutive signaling activity of SMO (PubMed:31657721). ShhN is widely expressed and plays a key role in the patterning of the central nervous system and limb development (PubMed:11430830, PubMed:12679031, PubMed:15315762, PubMed:24863049). Induces ventral cell fate in the neural tube and somites (PubMed:11430830, PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (PubMed:15315762). Essential for axon guidance (PubMed:12679031)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.4.25.1;5.3.4.1;3.6.4.-;3.1.-.-;3.6.4.6;2.3.1.-;3.1.1.98;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005539 glycosaminoglycan binding;GO:0005113 patched binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0030878 thyroid gland development;GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q62226-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SZT6-1", "uniprot_id": "Q5SZT6_MOUSE", "mass": 54069.0, "length": 480, "protein_name": "Zinc finger with KRAB and SCAN domains 4", "gene_name": "Zkscan4", "organism": "Mouse", "refseq_name": "zinc finger protein with KRAB and SCAN domains 4", "refseq_ac": "NP_001034204", "gene_names_uniprotkb": "Zkscan4", "gene_names_refseq": "Gm11272; Zkscan4", "protein_names_uniprotkb": "Zinc finger with KRAB and SCAN domains 4", "protein_names_refseq": "zinc finger protein with KRAB and SCAN domains 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:544922); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SZT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BI45-1", "uniprot_id": "A2BI45_MOUSE", "mass": 27190.0, "length": 236, "protein_name": "X-linked lymphocyte-regulated 5A", "gene_name": "Xlr5a", "organism": "Mouse", "refseq_name": "X-linked lymphocyte-regulated 5A", "refseq_ac": "NP_001039004", "gene_names_uniprotkb": "Xlr5a; Xlr5b", "gene_names_refseq": "Xlr5a; Xlr5d", "protein_names_uniprotkb": "X-linked lymphocyte-regulated 5A", "protein_names_refseq": "X-linked lymphocyte-regulated 5A; X-linked lymphocyte-regulated 5D", "tax_id": 10090, "disease": "", "pathway": " (mmu:574438)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BI45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X987-1", "uniprot_id": "GIMA9_MOUSE", "mass": 33298.0, "length": 291, "protein_name": "GTPase IMAP family member 9", "gene_name": "Gimap9", "organism": "Mouse", "refseq_name": "GTPase IMAP family member 9 isoform 1", "refseq_ac": "NP_777620", "gene_names_uniprotkb": "Gimap9; Ian7", "gene_names_refseq": "A630002K24; Gimap9; IAN-7", "protein_names_uniprotkb": "GTPase IMAP family member 9; IAN-7; Immune-associated nucleotide-binding protein 7; Immunity-associated nucleotide-binding protein 7", "protein_names_refseq": "GTPase IMAP family member 9 isoform 1; immune associated nucleotide family member; immune-associated nucleotide-binding protein 7; immunity-associated nucleotide-binding protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:317758)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16509771;21750661;25605945;34428180", "class_list": "", "function": "This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9U6;Q8CGH1", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3X987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RVI8-1", "uniprot_id": "ST2A6_MOUSE", "mass": 33317.0, "length": 285, "protein_name": "Sulfotransferase 2A6", "gene_name": "Sult2a6", "organism": "Mouse", "refseq_name": "sulfotransferase 2A6", "refseq_ac": "NP_001074794", "gene_names_uniprotkb": "Sult2a6; Gm6957", "gene_names_refseq": "BAST I; EG629219; Gm6957; ST2A6; Sult2a6", "protein_names_uniprotkb": "Sulfotransferase 2A6; 2.8.2.14; 2.8.2.2; BAST I; Bile acid:3'phosphoadenosine-5'phosphosulfate:sulfotransferase I; ST2A6", "protein_names_refseq": "bile acid:3'phosphoadenosine-5'phosphosulfate:sulfotransferase I; sulfotransferase 2A6; sulfotransferase family 2A member 1 family member", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:629219)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of the hydroxyl group of hydroxysteroids and bile acids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.4", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity;GO:0050294 steroid sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RVI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V2A7-1", "uniprot_id": "QRIC2_MOUSE", "mass": 66541.0, "length": 592, "protein_name": "Glutamine-rich protein 2", "gene_name": "Qrich2", "organism": "Mouse", "refseq_name": "glutamine-rich protein 2", "refseq_ac": "NP_001028439", "gene_names_uniprotkb": "Qrich2; Gm66", "gene_names_refseq": "Gm66; Qrich2", "protein_names_uniprotkb": "Glutamine-rich protein 2", "protein_names_refseq": "glutamine-rich protein 2", "tax_id": 10090, "disease": "spermatogenic failure 35 (Disease Ontology:DOID:0111914)", "pathway": " (mmu:217341)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;30683861;34415320;37352829;38597976;38772286", "class_list": "", "function": "A Key regulatory protein QRICH2 governing sperm function with profound antioxidant properties, enhancing sperm viability., [RefSeq, PubMed]; Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility., [UniProtKB, PubMed]; Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development., [RefSeq, PubMed]; Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm. Publication Status: Online-Only, [RefSeq, PubMed]; The findings strongly suggest that the genetic mutations of QRICH2 can lead to male infertility with multiple morphological abnormalities of the flagella, and that QRICH2 is essential for sperm flagellar formation. Erratum:[Nat Commun. 2019 May 20;10(1):2289. doi: 10.1038/s41467-019-10313-x. PMID: 31110204] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKM0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0036126 sperm flagellum", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:0030031 cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V2A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R5I6-1", "uniprot_id": "GSTM4_MOUSE", "mass": 25519.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 4", "gene_name": "Gstm4", "organism": "Mouse", "refseq_name": "glutathione S-transferase Mu 4 isoform 1", "refseq_ac": "NP_081040", "gene_names_uniprotkb": "Gstm4; Gstm7-7; Gstm7", "gene_names_refseq": "1110004G14Rik; GSTM4-4; GSTM7-7; Gstb-4; Gstb4; Gstm4", "protein_names_uniprotkb": "Glutathione S-transferase Mu 4; 2.5.1.18; 4.4.1.20; GST class-mu 4; GSTM4-4; Glutathione transferase GSTM7-7; Leukotriene C4 synthase GSTM4", "protein_names_refseq": "GST class-mu 4; glutathione S-transferase Mu 4 isoform 1; glutathione transferase GSTM7-7; leukotriene C4 synthase GSTM4", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14865); (R-MMU-156590); (R-MMU-9026762)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11991805;12069689;21750661", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;2.5.1.-;5.3.99.2;5.3.99.3;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0004464 leukotriene-C4 synthase activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0042759 long-chain fatty acid biosynthetic process;GO:0006749 glutathione metabolic process;GO:0018916 nitrobenzene metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R5I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1W2P739-1", "uniprot_id": "A0A1W2P739_MOUSE", "mass": 22905.0, "length": 225, "protein_name": "Keratin associated protein 10-29", "gene_name": "Krtap10-29", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC675294", "refseq_ac": "NP_001357753", "gene_names_uniprotkb": "Krtap10-29; Gm9639", "gene_names_refseq": "675294; Gm9639; Krtap10-29", "protein_names_uniprotkb": "Keratin associated protein 10-29", "protein_names_refseq": "uncharacterized protein LOC675294", "tax_id": 10090, "disease": "", "pathway": " (mmu:675294); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFZ4-1", "uniprot_id": "Q8VFZ4_MOUSE", "mass": 37438.0, "length": 326, "protein_name": "Olfactory receptor", "gene_name": "Or10a3m", "organism": "Mouse", "refseq_name": "olfactory receptor family 10 subfamily A member 3M", "refseq_ac": "NP_666935", "gene_names_uniprotkb": "Or10a3m; Olfr512", "gene_names_refseq": "MOR268-3; Olfr512; Or10a3m", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-11043421-11044365; olfactory receptor 512; olfactory receptor MOR268-3; olfactory receptor family 10 subfamily A member 3M", "tax_id": 10090, "disease": "", "pathway": " (mmu:258719)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIE4-1", "uniprot_id": "PAR10_MOUSE", "mass": 103679.0, "length": 960, "protein_name": "Protein mono-ADP-ribosyltransferase PARP10", "gene_name": "Parp10", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP10", "refseq_ac": "NP_001157047", "gene_names_uniprotkb": "Parp10", "gene_names_refseq": "ARTD10; PARP-10; Parp10", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP10; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 10; ARTD10; PARP-10; Poly [ADP-ribose] polymerase 10", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 10; poly [ADP-ribose] polymerase 10; protein mono-ADP-ribosyltransferase PARP10", "tax_id": 10090, "disease": "", "pathway": " (mmu:671535)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30097860;33020597", "class_list": "", "function": "ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA., [UniProtKB, UniProtKB]; Murine Artd8 macrodomain constructs can serve as a tool to evaluate intracellular ARTD10 auto-modification levels using the described methods, while the human ARTD8 macrodomains are less suited because of ADPr-independent binding to ARTD10. Protocols for co-immunoprecipitation and co-localization experiments are described in detail., [RefSeq, PubMed]; The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F6Z9X8;Q3TLV7;Q3U6C0;Q8BSZ1;Q8C8L6;Q8R133;Q8R1U9", "ec_number_list": "2.4.2.-;2.4.2.30;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003714 transcription corepressor activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0006281 DNA repair;GO:0010629 negative regulation of gene expression;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0048147 negative regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CIE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G5E8D7-1", "uniprot_id": "OOSP3_MOUSE", "mass": 22638.0, "length": 195, "protein_name": "Oocyte-secreted protein 3", "gene_name": "Oosp3", "organism": "Mouse", "refseq_name": "oocyte-secreted protein 3 precursor", "refseq_ac": "NP_001028455", "gene_names_uniprotkb": "Oosp3", "gene_names_refseq": "Gm97; Oosp3", "protein_names_uniprotkb": "Oocyte-secreted protein 3", "protein_names_refseq": "oocyte-secreted protein 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:225923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12237121;21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EIY2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G5E8D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z120-1", "uniprot_id": "FOXI3_MOUSE", "mass": 42015.0, "length": 399, "protein_name": "Forkhead box protein I3", "gene_name": "Foxi3", "organism": "Mouse", "refseq_name": "forkhead box protein I3", "refseq_ac": "NP_001094934", "gene_names_uniprotkb": "Foxi3", "gene_names_refseq": "Foxi3", "protein_names_uniprotkb": "Forkhead box protein I3", "protein_names_refseq": "forkhead box protein I3", "tax_id": 10090, "disease": "Goldenhar syndrome (Disease Ontology:DOID:2907)", "pathway": " (mmu:232077)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15376323;21750661;23441037;24650709;26450968;26550799;26992132;30467319;31412026;37041148;37756587;38433559", "class_list": "", "function": "Eda and activin A are upstream regulators of Foxi3 in skin appendage placodes, [RefSeq, PubMed]; Foxi3 expressed in a broad region of the pan-placodal ectoderm adjacent to the neural plate from E6.75 to first somite stage; expression restricted to ectoderm & endoderm of branchial pouches at E10.5, [RefSeq, PubMed]; Identification of potential molecular mechanism related to craniofacial dysmorphism caused by FOXI3 deficiency., [RefSeq, PubMed]; The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border., [RefSeq, PubMed]; Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development (PubMed:24650709, PubMed:26550799, PubMed:26992132, PubMed:30467319). May act as a pioneer transcription factor during pharyngeal arch development (PubMed:26550799, PubMed:26992132). Required for epithelial cell differentiation within the epidermis (PubMed:26450968). Acts at multiple stages of otic placode induction: necessary for preplacodal ectoderm to execute an inner ear program (PubMed:26550799). Required for hair follicle stem cell specification (PubMed:26992132). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (PubMed:31412026)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E0CZH3", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060017 parathyroid gland development;GO:0006351 DNA-templated transcription;GO:0048538 thymus development;GO:0001942 hair follicle development;GO:0042475 odontogenesis of dentin-containing tooth", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "D3Z120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63ZW6-1", "uniprot_id": "CO4A5_MOUSE", "mass": 161807.0, "length": 1691, "protein_name": "Collagen alpha-5(IV) chain", "gene_name": "Col4a5", "organism": "Mouse", "refseq_name": "collagen alpha-5(IV) chain isoform 1 precursor", "refseq_ac": "NP_001156627", "gene_names_uniprotkb": "Col4a5", "gene_names_refseq": "Col4a5", "protein_names_uniprotkb": "Collagen alpha-5(IV) chain", "protein_names_refseq": "collagen alpha-5(IV) chain isoform 1 precursor; collagen alpha-5(IV) chain; collagen type IV alpha5 chain; procollagen type IV alpha 5", "tax_id": 10090, "disease": "X-linked Alport syndrome (Disease Ontology:DOID:0110034); Alport syndrome (Disease Ontology:DOID:10983); dilated cardiomyopathy (Disease Ontology:DOID:12930); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:12830); (R-MMU-1442490); (R-MMU-1566977); (R-MMU-1650814); (R-MMU-2022090); (R-MMU-216083); (R-MMU-2243919); (R-MMU-3000157); (R-MMU-3000171)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "10965041;25428506", "class_list": "", "function": "Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F7CK55;Q3TP61;Q9ESQ2", "ec_number_list": "", "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0005604 basement membrane;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63ZW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z5S8-1", "uniprot_id": "TET5A_MOUSE", "mass": 50793.0, "length": 447, "protein_name": "Terminal nucleotidyltransferase 5A", "gene_name": "Tent5a", "organism": "Mouse", "refseq_name": "terminal nucleotidyltransferase 5A isoform 1", "refseq_ac": "NP_001153850", "gene_names_uniprotkb": "Tent5a; Fam46a", "gene_names_refseq": "BAP014; D930050G01Rik; Fam46a; Tent5a", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5A; 2.7.7.19", "protein_names_refseq": "family with sequence similarity 46, member A; terminal nucleotidyltransferase 5A isoform 1", "tax_id": 10090, "disease": "osteogenesis imperfecta type 18 (Disease Ontology:DOID:0111848); lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:212943)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19740458;21750661;26803617;29358272;33882302", "class_list": "", "function": "By RT-PCR analysis, we detected specific expression of FAM46A in human osteoblasts andinterestingly, a nonsense mutation in Fam46a has been recently identified in an ENU-derived (N-ethyl-N-nitrosourea) mouse model characterised by decreased body length, limb, rib, pelvis, and skull deformities and reduced cortical thickness in long bones., [RefSeq, PubMed]; Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation (PubMed:33882302). Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (PubMed:26803617, PubMed:33882302)., [UniProtKB, PubMed, PubMed]; Expressed in ameloblasts' nuclei of tooth germs and might act together with morphogenetic factors important for the formation of enamel in mouse tooth, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0009617 response to bacterium;GO:0030501 positive regulation of bone mineralization;GO:0030278 regulation of ossification;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3Z5S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G5E8L3-1", "uniprot_id": "G5E8L3_MOUSE", "mass": 25500.0, "length": 226, "protein_name": "N-acetyltransferase 8 (GCN5-related) family member 4", "gene_name": "Nat8f4", "organism": "Mouse", "refseq_name": "N-acetyltransferase family 8 member 4 isoform 1", "refseq_ac": "NP_083607", "gene_names_uniprotkb": "Nat8f4; 1700019G17Rik", "gene_names_refseq": "1700019G17Rik; Nat8f4", "protein_names_uniprotkb": "N-acetyltransferase 8 (GCN5-related) family member 4", "protein_names_refseq": "N-acetyltransferase family 8 member 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75541)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008080 N-acetyltransferase activity;GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0018003 peptidyl-lysine N6-acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G5E8L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGC6-1", "uniprot_id": "Q8VGC6_MOUSE", "mass": 34537.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or5ak22", "organism": "Mouse", "refseq_name": "olfactory receptor family 5 subfamily AK member 22", "refseq_ac": "NP_667076", "gene_names_uniprotkb": "Or5ak22; Olfr992", "gene_names_refseq": "MOR203-1; Olfr992; Or5ak22", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-46877170-46876241; olfactory receptor 992; olfactory receptor MOR203-1; olfactory receptor family 5 subfamily AK member 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:258865)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VGC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PVU2-1", "uniprot_id": "E9PVU2_MOUSE", "mass": 42811.0, "length": 379, "protein_name": "RIKEN cDNA 4931429L15 gene", "gene_name": "4931429L15Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC74361", "refseq_ac": "NP_898927", "gene_names_uniprotkb": "4931429L15Rik", "gene_names_refseq": "4931429L15Rik", "protein_names_uniprotkb": "RIKEN cDNA 4931429L15 gene", "protein_names_refseq": "uncharacterized protein LOC74361", "tax_id": 10090, "disease": "", "pathway": " (mmu:74361)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PVU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AV10-1", "uniprot_id": "A2AV10_MOUSE", "mass": 35176.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or4c101", "organism": "Mouse", "refseq_name": "olfactory receptor 1188", "refseq_ac": "NP_667130", "gene_names_uniprotkb": "Or4c101; Olfr1188", "gene_names_refseq": "MOR238-2; Olfr1188; Or4c101", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-50046879-50047784; olfactory receptor 1188; olfactory receptor MOR238-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258921)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AV10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z689-1", "uniprot_id": "D3Z689_MOUSE", "mass": 53593.0, "length": 485, "protein_name": "ADAMTS-like 5", "gene_name": "Adamtsl5", "organism": "Mouse", "refseq_name": "ADAMTS-like protein 5", "refseq_ac": "NP_001272364", "gene_names_uniprotkb": "Adamtsl5", "gene_names_refseq": "2010109H09Rik; Adamtsl5; Thsd6", "protein_names_uniprotkb": "ADAMTS-like 5", "protein_names_refseq": "ADAMTS-like protein 5; thrombospondin, type I domain containing 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66548); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0050436 microfibril binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z689-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGX1-1", "uniprot_id": "Q8VGX1_MOUSE", "mass": 35839.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Or7g17", "organism": "Mouse", "refseq_name": "olfactory receptor family 7 subfamily G member 17", "refseq_ac": "NP_667278", "gene_names_uniprotkb": "Or7g17; Olfr829", "gene_names_refseq": "MOR147-1; Olfr829; Or7g17", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-12599710-12600648; olfactory receptor 829; olfactory receptor MOR147-1; olfactory receptor family 7 subfamily G member 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:259070)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q8L6-1", "uniprot_id": "E9Q8L6_MOUSE", "mass": 33101.0, "length": 297, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r132", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 132", "refseq_ac": "NP_001116154", "gene_names_uniprotkb": "Vmn1r132; 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Dutp", "gene_names_refseq": "5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Dutp; Dut; dUTPase", "protein_names_uniprotkb": "Deoxyuridine 5'-triphosphate nucleotidohydrolase; 3.6.1.23; dUTPase", "protein_names_refseq": "deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:110074); (R-MMU-499943)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22645316;28528544;30987342;38849394", "class_list": "", "function": "Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (By similarity). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (PubMed:30987342)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Characterization of dUTPase expression in mouse postnatal development and adult neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; DUTPase is essential for embryonic development since early dut -/- embryos die shortly after implantation. dut +/- animals are viable while having decreased dUTPase levels. 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Olfr582; Olfr584", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:259055)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TRS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VET5-1", "uniprot_id": "Q8VET5_MOUSE", "mass": 35057.0, "length": 316, "protein_name": "Olfactory receptor family 10 subfamily D member 4B", "gene_name": "Or10d4b", "organism": "Mouse", "refseq_name": "olfactory receptor family 10 subfamily D member 4B", "refseq_ac": "NP_666391", "gene_names_uniprotkb": "Or10d4b; Olfr960", "gene_names_refseq": "MOR224-12; Olfr960; Or10d4b", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily D member 4B", "protein_names_refseq": "GA_x6K02T2PVTD-33320043-33320987; olfactory receptor 960; olfactory receptor MOR224-12; olfactory receptor family 10 subfamily D member 4B", "tax_id": 10090, "disease": "", "pathway": " (mmu:258276)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VET5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61554-1", "uniprot_id": "FBN1_MOUSE", "mass": 312298.0, "length": 2873, "protein_name": "Fibrillin-1", "gene_name": "Fbn1", "organism": "Mouse", "refseq_name": "fibrillin-1 preproprotein", "refseq_ac": "NP_032019", "gene_names_uniprotkb": "Fbn1; Fbn-1", "gene_names_refseq": "B430209H23; Fbn1; Fib-1; Tsk", "protein_names_uniprotkb": "Fibrillin-1", "protein_names_refseq": "fibrillin-1 preproprotein; tight skin", "tax_id": 10090, "disease": "Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); CREST syndrome (Disease Ontology:DOID:0060218); scoliosis (Disease Ontology:DOID:0060249); aortic dissection (Disease Ontology:DOID:0080685); autosomal dominant isolated ectopia lentis 1 (Disease Ontology:DOID:0111150); acromicric dysplasia (Disease Ontology:DOID:0111243); stiff skin syndrome (Disease Ontology:DOID:0111561); geleophysic dysplasia 2 (Disease Ontology:DOID:0111726); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); Marfan syndrome (Disease Ontology:DOID:14323); glomerulonephritis (Disease Ontology:DOID:2921); mixed connective tissue disease (Disease Ontology:DOID:3492); aortic aneurysm (Disease Ontology:DOID:3627); systemic scleroderma (Disease Ontology:DOID:418); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); liver cirrhosis (Disease Ontology:DOID:5082); type 2 diabetes mellitus (Disease Ontology:DOID:9352); refractive error (Disease Ontology:DOID:9835); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:14118); (R-MMU-1474228); (R-MMU-1566948); (R-MMU-2129379); (R-MMU-216083); (R-MMU-2173789); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 8, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;16407178;19940141;20855508;21183079;24039232;27087445;29106398;30997682;31230984;31798959;32337066;33705351;36288343;39927985;7829516", "class_list": "", "function": "Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:30997682, PubMed:31230984). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:31230984). Binds the olfactory receptor Olfr734 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (PubMed:33705351). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (PubMed:29106398). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (PubMed:29106398, PubMed:32337066). Activates orexigenic AgRP neurons via binding to the olfactory receptor Olfr734 (PubMed:32337066). May also play a role in sperm motility in testis via interaction with Olfr734 receptor (PubMed:31798959)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (By similarity). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Homozygous knockout mice for this gene exhibit impaired aortic development and early postnatal death, which was attributed to a deficiency in the fibrillin-1 protein. Mice with a hypomorphic allele of this gene exhibit impaired glucose homeostasis, likely due to a reduction in serum asprosin levels. [provided by RefSeq, Apr 2016]., [RefSeq]", "predicted_glycosites": 32, "predicted_n_glycosites": 11, "predicted_o_glycosites": 21, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 20, "glyco_site_count": 36, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ53;Q60826", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0001527 microfibril", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0048286 lung alveolus development;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q61554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61555-1", "uniprot_id": "FBN2_MOUSE", "mass": 313818.0, "length": 2907, "protein_name": "Fibrillin-2", "gene_name": "Fbn2", "organism": "Mouse", "refseq_name": "fibrillin-2 precursor", "refseq_ac": "NP_034311", "gene_names_uniprotkb": "Fbn2; Fbn-2", "gene_names_refseq": "Fbn2; Fib-2; mKIAA4226; sne; sy", "protein_names_uniprotkb": "Fibrillin-2", "protein_names_refseq": "fibrillin-2 precursor; syndatyly ems", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); scoliosis (Disease Ontology:DOID:0060249); congenital contractural arachnodactyly (Disease Ontology:DOID:0111595); Marfan syndrome (Disease Ontology:DOID:14323)", "pathway": " (mmu:14119); (R-MMU-1474228); (R-MMU-1566948); (R-MMU-2129379)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11470817;16407178;20855508;24039232;25428506;32329225;7744963;8307578", "class_list": "", "function": "Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles (PubMed:20855508). Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508)., [UniProtKB, PubMed]; Hormone secreted by trophoblasts that promotes trophoblast invasiveness (By similarity). Has glucogenic activity: is able to increase plasma glucose levels (PubMed:32329225)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 42, "predicted_n_glycosites": 12, "predicted_o_glycosites": 30, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 42, "binding_glycan_count": 0, "secondary_ac_list": "E9QJZ4;Q63957", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0001890 placenta development;GO:0030326 embryonic limb morphogenesis;GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NS60-1", "uniprot_id": "FBX41_MOUSE", "mass": 94331.0, "length": 873, "protein_name": "F-box only protein 41", "gene_name": "Fbxo41", "organism": "Mouse", "refseq_name": "F-box only protein 41", "refseq_ac": "NP_001001160", "gene_names_uniprotkb": "Fbxo41; D6Ertd538e; Kiaa1940", "gene_names_refseq": "9630017H13; D6Ertd538e; Fbxo41", "protein_names_uniprotkb": "F-box only protein 41", "protein_names_refseq": "F-box only protein 41", "tax_id": 10090, "disease": "", "pathway": " (mmu:330369); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16452087;21183079;22517741;22645316;24129315;31160656;32848054;34678516;40885482", "class_list": "", "function": "Fbxo41 Promotes Disassembly of Neuronal Primary Cilia. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7W4;Q6ZPG1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse", "go_biological_process": "GO:0001764 neuron migration;GO:0007268 chemical synaptic transmission;GO:0021766 hippocampus development;GO:0010467 gene expression;GO:0021542 dentate gyrus development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6NS60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76LL6-1", "uniprot_id": "FHOD3_MOUSE", "mass": 175655.0, "length": 1578, "protein_name": "FH1/FH2 domain-containing protein 3", "gene_name": "Fhod3", "organism": "Mouse", "refseq_name": "FH1/FH2 domain-containing protein 3 isoform 2", "refseq_ac": "NP_001276583", "gene_names_uniprotkb": "Fhod3; Fhos2; Kiaa1695", "gene_names_refseq": "A930009H06Rik; FHOS2; Fhod3; mKIAA1695", "protein_names_uniprotkb": "FH1/FH2 domain-containing protein 3; Formin homolog overexpressed in spleen 2; mFHOS2", "protein_names_refseq": "FH1/FH2 domain-containing protein 3 isoform 2; FH1/FH2 domain-containing protein 3; formin homolog overexpressed in spleen 2; formin-family protein FHOS2", "tax_id": 10090, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326)", "pathway": " (mmu:225288)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15966898;19706596;21149568;21183079;21750661;22509354;22872234;23052206;30016717;30779550;33251537;34418053;34428180;36288343;38498576", "class_list": "", "function": "Actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells., [RefSeq, PubMed]; Altered Fhod3 expression involved in progressive high-frequency hearing loss via dysregulation of actin polymerization stoichiometry in the cuticular plate. Publication Status: Online-Only, [RefSeq, PubMed]; Analysis of casein kinase 2 alpha knockout mice showed that phosphorylation by casein kinase 2 is also required for proper targeting of muscle Fhod3 to the myofibrils in embryonic cardiomyocytes in situ., [RefSeq, PubMed]; Embryonic heart of mice specifically expresses the Fhod3 mRNA isoform harboring the three alternative exons, [RefSeq, PubMed]; Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex., [RefSeq, PubMed]; May play a role in actin filament polymerization in cardiomyocytes (By similarity). Actin-organizing protein that may cause stress fiber formation together with cell elongation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RQR3;Q5DTV7;Q76HP7;Q76LL5", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0030018 Z disc", "go_biological_process": "GO:0007015 actin filament organization;GO:0051496 positive regulation of stress fiber assembly;GO:0055003 cardiac myofibril assembly;GO:0045214 sarcomere organization;GO:0051639 actin filament network formation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q76LL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922J9-1", "uniprot_id": "FACR1_MOUSE", "mass": 59435.0, "length": 515, "protein_name": "Fatty acyl-CoA reductase 1", "gene_name": "Far1", "organism": "Mouse", "refseq_name": "fatty acyl-CoA reductase 1 isoform 2", "refseq_ac": "NP_001272760", "gene_names_uniprotkb": "Far1", "gene_names_refseq": "2600011M19Rik; 2900034E22Rik; 3732409C05Rik; Far1; Mlstd2", "protein_names_uniprotkb": "Fatty acyl-CoA reductase 1; 1.2.1.84; Far1", "protein_names_refseq": "fatty acyl-CoA reductase 1 isoform 2; male sterility domain containing 2", "tax_id": 10090, "disease": "rhizomelic chondrodysplasia punctate type 4 (Disease Ontology:DOID:0081243)", "pathway": " (mmu:67420); (R-MMU-9640463)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15220348;15220349;21750661;31219806;34428180;37828378", "class_list": "", "function": "Catalyzes the reduction of fatty acyl-CoA to fatty alcohols., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:15220349). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (By similarity). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (PubMed:15220349)., [UniProtKB, UniProtKB, PubMed, PubMed]; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids, [RefSeq, PubMed]; Wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZS2;Q9CXE8;Q9D0Q1;Q9DAU2", "ec_number_list": "1.2.1.84", "go_molecular_function": "GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0008611 ether lipid biosynthetic process;GO:0046474 glycerophospholipid biosynthetic process;GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:0010025 wax biosynthetic process;GO:1901568 fatty acid derivative metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q922J9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPY9-1", "uniprot_id": "FIGL1_MOUSE", "mass": 74850.0, "length": 683, "protein_name": "Fidgetin-like protein 1", "gene_name": "Fignl1", "organism": "Mouse", "refseq_name": "fidgetin-like protein 1 isoform 1", "refseq_ac": "NP_001156831", "gene_names_uniprotkb": "Fignl1", "gene_names_refseq": "Fignl1", "protein_names_uniprotkb": "Fidgetin-like protein 1; 3.6.4.-", "protein_names_refseq": "fidgetin-like protein 1 isoform 1; fidgetin-like protein 1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742)", "pathway": " (mmu:60530); (R-MMU-5693568); (R-MMU-912446)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11017077;17352653;21750661;22110678;22872234;25428506;30779550;31219806;34428180;35820727;37439366;37828378;37891173;39147779;39636933", "class_list": "", "function": "ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:37439366, PubMed:37891173, PubMed:39636933). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:39636933). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (PubMed:37439366, PubMed:37891173, PubMed:39147779). May regulate osteoblast proliferation and differentiation (PubMed:17352653)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination. Publication Status: Online-Only, [RefSeq, PubMed]; FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation., [RefSeq, PubMed]; The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF48;Q8C2I6;Q9ERZ5", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;5.6.2.1;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;2.7.11.1;3.4.21.53;2.7.7.7;2.7.7.49;2.3.1.48;2.3.1.-;2.7.4.3", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000228 nuclear chromosome;GO:1990391 DNA repair complex", "go_biological_process": "GO:0033687 osteoblast proliferation;GO:0051013 microtubule severing;GO:0043066 negative regulation of apoptotic process;GO:0001649 osteoblast differentiation;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BPY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPG6-1", "uniprot_id": "TAFA3_MOUSE", "mass": 14426.0, "length": 132, "protein_name": "Chemokine-like protein TAFA-3", "gene_name": "Tafa3", "organism": "Mouse", "refseq_name": "chemokine-like protein TAFA-3 precursor", "refseq_ac": "NP_899047", "gene_names_uniprotkb": "Tafa3; Fam19a3", "gene_names_refseq": "7530404M11Rik; Fam19a3; Sam3; Tafa-3; Tafa3", "protein_names_uniprotkb": "Chemokine-like protein TAFA-3", "protein_names_refseq": "chemokine-like protein TAFA-3 precursor; chemokine-like protein TAFA-3; family with sequence similarity 19, member A3; protein FAM19A3", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:329731)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15028294;22426341;25595455", "class_list": "", "function": "Plays a role in the regulation of microglia polarization., [UniProtKB, PubMed]; The data suggest that TAFA-3 is a signaling molecule from the hypophysial pars tuberalis., [RefSeq, PubMed]; This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q147Z7", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:1903980 positive regulation of microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TPG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQM9-1", "uniprot_id": "GLRX3_MOUSE", "mass": 37778.0, "length": 337, "protein_name": "Glutaredoxin-3", "gene_name": "Glrx3", "organism": "Mouse", "refseq_name": "glutaredoxin-3 isoform 1", "refseq_ac": "NP_075629", "gene_names_uniprotkb": "Glrx3; Picot; Txnl2", "gene_names_refseq": "Glrx3; PICOT; Txnl2", "protein_names_uniprotkb": "Glutaredoxin-3; PICOT; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2", "protein_names_refseq": "PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; glutaredoxin-3 isoform 1; thioredoxin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:30926)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10636891;16809552;18258855;18929570;21750661;22645316;30084848;31033205;31176019;33300544;34345213;34428180;36739698;37507081;39927985", "class_list": "", "function": "Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Grx3 CKO mice exhibited increase of ROS production, impaired Ca2+ handling, left ventricular hypertrophy and heart failure., [RefSeq, PubMed]; Liver specific disruption of Glutaredoxin 3 leads to iron accumulation and impaired cellular iron homeostasis., [RefSeq, PubMed]; PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response., [RefSeq, PubMed]; PICOT inhibits cardiac hypertrophy induced by pressure overload; overexpression increased ventricular function and cardiomyocyte contractility measured by ejection fraction & end-systolic pressure of transgenic hearts & peak shortening of cardiomyocytes, [RefSeq, PubMed]; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (PubMed:16809552, PubMed:18258855, PubMed:18929570). Required for hemoglobin maturation. Does not possess any thioredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0V8;Q9JLZ2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030425 dendrite;GO:0030018 Z disc", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0045454 cell redox homeostasis;GO:0002026 regulation of the force of heart contraction;GO:0010614 negative regulation of cardiac muscle hypertrophy", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9CQM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUH0-1", "uniprot_id": "GLRX1_MOUSE", "mass": 11871.0, "length": 107, "protein_name": "Glutaredoxin-1", "gene_name": "Glrx", "organism": "Mouse", "refseq_name": "glutaredoxin-1", "refseq_ac": "NP_444338", "gene_names_uniprotkb": "Glrx; Glrx1; Grx1; Grx", "gene_names_refseq": "D13Wsu156e; Glrx1; Glrx; Grx1; TTase", "protein_names_uniprotkb": "Glutaredoxin-1; TTase-1; Thioltransferase-1", "protein_names_refseq": "TTase-1; glutaredoxin (thioltransferase); glutaredoxin 1 (thioltransferase); glutaredoxin-1; thioltransferase-1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:93692); (R-MMU-499943)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10517541;10647820;21750661;23806337;26740625;34428180;37277061;37277068;37735974;38061313", "class_list": "", "function": "Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation., [RefSeq, PubMed]; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins., [UniProtKB, UniProtKB, UniProtKB]; Macrophage-restricted overexpression of glutaredoxin 1 protects against atherosclerosis by preventing nutrient stress-induced macrophage dysfunction and reprogramming., [RefSeq, PubMed]; NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m[6] A methylation through upregulation of METTL3 transcription., [RefSeq, PubMed]; The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015038 glutathione disulfide oxidoreductase activity;GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0060355 positive regulation of cell adhesion molecule production;GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0032024 positive regulation of insulin secretion;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0071392 cellular response to estradiol stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QUH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Y14-1", "uniprot_id": "GLRX5_MOUSE", "mass": 16292.0, "length": 152, "protein_name": "Glutaredoxin-related protein 5, mitochondrial", "gene_name": "Glrx5", "organism": "Mouse", "refseq_name": "glutaredoxin-related protein 5, mitochondrial", "refseq_ac": "NP_082695", "gene_names_uniprotkb": "Glrx5", "gene_names_refseq": "Glrx5", "protein_names_uniprotkb": "Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin-5", "protein_names_refseq": "glutaredoxin 5 homolog; glutaredoxin-related protein 5, mitochondrial; monothiol glutaredoxin-5", "tax_id": 10090, "disease": "autosomal recessive pyridoxine-refractory sideroblastic anemia 3 (Disease Ontology:DOID:0080343)", "pathway": " (mmu:73046); (R-MMU-1362409)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16110529;19442627;21183079;21750661;23806337;28542222;36288343;38100056", "class_list": "", "function": "Exosomes from hypoxic pretreated ADSCs attenuate ultraviolet light-induced skin injury via GLRX5 delivery and ferroptosis inhibition., [RefSeq, PubMed]; Grx5 is an important determinant of osteoblast apoptosis and acts via a molecular pathway that involves regulation of ROS production, cardiolipin oxidation, caspase activity, Fe-S cluster formation, and MnSOD activity., [RefSeq, PubMed]; Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:19442627). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Study reports a decrease of Grx expression levels in pancreatic islets of diabetic mice which was accompanied by declining insulin secretion, increase of reactive oxygen species (ROS) production level, and cell cycle alterations. These data demonstrate the essential role of the Grx system for the beta-cell during metabolic stress which may provide a new target for diabetes mellitus type 2 treatment. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in the human gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3YML1;Q9D6E9", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "GO:0030097 hemopoiesis;GO:0051604 protein maturation;GO:0044571 [2Fe-2S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80Y14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55095-1", "uniprot_id": "GLUC_MOUSE", "mass": 20906.0, "length": 180, "protein_name": "Pro-glucagon", "gene_name": "Gcg", "organism": "Mouse", "refseq_name": "pro-glucagon preproprotein", "refseq_ac": "NP_032126", "gene_names_uniprotkb": "Gcg", "gene_names_refseq": "GLP-1; Gcg; Glu; PPG", "protein_names_uniprotkb": "Pro-glucagon", "protein_names_refseq": "glucagon-like peptide I; pro-glucagon preproprotein; pro-glucagon", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); prediabetes syndrome (Disease Ontology:DOID:11716)", "pathway": " (mmu:14526); (R-MMU-163359); (R-MMU-381676); (R-MMU-381771); (R-MMU-416476); (R-MMU-418555); (R-MMU-420092); (R-MMU-422085)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10322410;10605628;11356850;12554744;12626323;14719035;1886889;21183079;21750661;22037645;25333865;25428506;32152506;7730317;9407057", "class_list": "", "function": "May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life., [UniProtKB, PubMed, PubMed]; Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Binds to and activates the glucagon receptor GCGR, which couples to the G(s) G protein and elevates intracellular cAMP, triggering downstream metabolic responses., [UniProtKB, PubMed, PubMed]; Potent stimulator of glucose-dependent insulin release (PubMed:22037645). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness., [UniProtKB, PubMed, PubMed]; Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFE9", "ec_number_list": "", "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031767 gastric inhibitory polypeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0034774 secretory granule lumen;GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0071377 cellular response to glucagon stimulus;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P55095-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88958-1", "uniprot_id": "GNPI1_MOUSE", "mass": 32549.0, "length": 289, "protein_name": "Glucosamine-6-phosphate deaminase 1", "gene_name": "Gnpda1", "organism": "Mouse", "refseq_name": "glucosamine-6-phosphate deaminase 1", "refseq_ac": "NP_036067", "gene_names_uniprotkb": "Gnpda1; Gnpi", "gene_names_refseq": "GNPDA; Gnp1; Gnpda1; Gnpi; oscillin", "protein_names_uniprotkb": "Glucosamine-6-phosphate deaminase 1; 3.5.99.6; GlcN6P deaminase 1; Glucosamine-6-phosphate isomerase 1; Protein oscillin", "protein_names_refseq": "GNPDA 1; glcN6P deaminase 1; glucosamine-6-phosphate deaminase 1; glucosamine-6-phosphate isomerase 1; glucose-6-phosphate isomerase; protein oscillin", "tax_id": 10090, "disease": "", "pathway": " (mmu:26384); (R-MMU-70171)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10481053;10862010;21183079;21750661;31219806;34428180;37507081", "class_list": "glycogene", "function": "Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (By similarity). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WJ4;Q9R188", "ec_number_list": "3.5.99.6", "go_molecular_function": "GO:0004342 glucosamine-6-phosphate deaminase activity;GO:0042802 identical protein binding;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006043 glucosamine catabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0007340 acrosome reaction;GO:0046370 fructose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88958-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XP5-1", "uniprot_id": "GLRA3_MOUSE", "mass": 53709.0, "length": 464, "protein_name": "Glycine receptor subunit alpha-3", "gene_name": "Glra3", "organism": "Mouse", "refseq_name": "glycine receptor subunit alpha-3 isoform 1 precursor", "refseq_ac": "NP_536686", "gene_names_uniprotkb": "Glra3", "gene_names_refseq": "Glra3", "protein_names_uniprotkb": "Glycine receptor subunit alpha-3", "protein_names_refseq": "glycine receptor subunit alpha-3 isoform 1 precursor; glycine receptor subunit alpha-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:110304); (R-MMU-112314)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12975813;15131310;19723286;20978350;21183079;21750661;37598301;39125713", "class_list": "", "function": "A phospho-deficient alpha3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons., [RefSeq, PubMed]; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15131310, PubMed:20978350). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:15131310). Contributes to increased pain perception in response to increased prostaglandin E2 levels (PubMed:15131310). Plays a role in the regulation of breathing rhythm, especially of the duration of the postinspiratory phase (PubMed:20978350). Plays a role in cellular responses to ethanol (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Study on the Mechanisms of Glralpha3 in Pain Sensitization of Endometriosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSQ2", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022852 glycine-gated chloride ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0016594 glycine binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016935 glycine-gated chloride channel complex;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0097688 glutamate receptor clustering;GO:0051260 protein homooligomerization;GO:0071361 cellular response to ethanol;GO:1902476 chloride transmembrane transport;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91XP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08795-1", "uniprot_id": "GLU2B_MOUSE", "mass": 58793.0, "length": 521, "protein_name": "Glucosidase 2 subunit beta", "gene_name": "Prkcsh", "organism": "Mouse", "refseq_name": "glucosidase 2 subunit beta isoform 1 precursor", "refseq_ac": "NP_001280579", "gene_names_uniprotkb": "Prkcsh", "gene_names_refseq": "80K-H; PKCSH; Prkcsh", "protein_names_uniprotkb": "Glucosidase 2 subunit beta; 80K-H protein; Glucosidase II subunit beta; PKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain", "protein_names_refseq": "alpha glucosidase II, beta-subunit; carbohydrate processing enzyme of the endoplasmic reticulum; glucosidase 2 subunit beta isoform 1 precursor; glucosidase 2 subunit beta; glucosidase II beta-subunit; hepatocystin; protein kinase C substrate 60.1 kDa protein heavy chain", "tax_id": 10090, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic liver disease 1 (Disease Ontology:DOID:0060980); liver disease (Disease Ontology:DOID:409)", "pathway": " (mmu:19089); (R-MMU-381426); (R-MMU-8957275); (R-MMU-9768727)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;21685914;21750661;22645316;23806337;26495903;27462106;30899004;31219806;31599954;31616917;32152506;37453647;37828378;40997131;9148925", "class_list": "glycogene", "function": "Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:27462106, PubMed:9148925). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (PubMed:21685914)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q921X2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0044325 transmembrane transporter binding;GO:0051219 phosphoprotein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043231 intracellular membrane-bounded organelle;GO:0017177 glucosidase II complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0010977 negative regulation of neuron projection development;GO:0006491 N-glycan processing;GO:0071941 nitrogen cycle metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O08795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18872-1", "uniprot_id": "GNAO_MOUSE", "mass": 40085.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(o) subunit alpha", "gene_name": "Gnao1", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(o) subunit alpha isoform B", "refseq_ac": "NP_001106855", "gene_names_uniprotkb": "Gnao1; Gna0; Gnao", "gene_names_refseq": "Galphao; Gnao1; Gnao; Hg1g; alphaO", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(o) subunit alpha; 3.6.5.-", "protein_names_refseq": "GTP-binding protein alpha-o subunit; Go alpha; guanine nucleotide-binding protein G(o) subunit alpha isoform B; guanine nucleotide-binding protein G(o) subunit alpha; heterotrimeric guanine nucleotide-binding protein 1g", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 17 (Disease Ontology:DOID:0080450); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); neurodevelopmental disorder with involuntary movements (Disease Ontology:DOID:0112276); McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:14681); (R-MMU-4086398)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10926822;15585744;16479539;1697681;18434540;21750661;22645316;23022564;28528544;31219806;33300544;34203471;34428180;38331815;38866563", "class_list": "", "function": "AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; The Schwann cell-specific G-protein Galphao (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P18873", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0003924 GTPase activity;GO:0005102 signaling receptor binding;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0043547 positive regulation of GTPase activity;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P18872-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47806-1", "uniprot_id": "GLI1_MOUSE", "mass": 118560.0, "length": 1111, "protein_name": "Transcription activator GLI1", "gene_name": "Gli1", "organism": "Mouse", "refseq_name": "zinc finger protein GLI1", "refseq_ac": "NP_034426", "gene_names_uniprotkb": "Gli1; Gli", "gene_names_refseq": "Gli1; Zfp-5; Zfp5", "protein_names_uniprotkb": "Transcription activator GLI1; Glioma-associated oncogene homolog", "protein_names_refseq": "glioma-associated oncogene homolog; zinc finger protein 5; zinc finger protein GLI1", "tax_id": 10090, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly I (Disease Ontology:DOID:0060987); spina bifida (Disease Ontology:DOID:0080016); multiple sclerosis (Disease Ontology:DOID:2377); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); gallbladder cancer (Disease Ontology:DOID:3121); gastric papillary adenocarcinoma (Disease Ontology:DOID:5593); gastric tubular adenocarcinoma (Disease Ontology:DOID:6595); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (mmu:14632); (R-MMU-5610780); (R-MMU-5610787); (R-MMU-5632684)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10433919;10725236;11748151;17442700;19015273;19592253;20956384;8364225;9524201", "class_list": "", "function": "Transcription activator that acts as a key effector of the smoothened signaling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract (PubMed:10433919, PubMed:10725236, PubMed:11748151, PubMed:17442700, PubMed:19015273). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:17442700). Activated in response to smoothened signaling: in presence of hedgehog (DHH, IHH or SHH) and subsequent activation of smoothened, GLI1 translocates to the nucleus and promotes expression of target genes (PubMed:11748151). In contrast to GLI2 and GLI3, does not contain a repressor domain and only acts as a transcription activator (PubMed:10433919)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G5E857;Q9QYK1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007418 ventral midline development;GO:0009913 epidermal cell differentiation;GO:0021696 cerebellar cortex morphogenesis;GO:0060032 notochord regression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48168-1", "uniprot_id": "GLRB_MOUSE", "mass": 55951.0, "length": 496, "protein_name": "Glycine receptor subunit beta", "gene_name": "Glrb", "organism": "Mouse", "refseq_name": "glycine receptor subunit beta isoform 7", "refseq_ac": "NP_001268898", "gene_names_uniprotkb": "Glrb", "gene_names_refseq": "Glrb; Glyrb; spastic; spa", "protein_names_uniprotkb": "Glycine receptor subunit beta; Glycine receptor 58 kDa subunit", "protein_names_refseq": "glycine receptor 58 kDa subunit; glycine receptor subunit beta isoform 7; glycine receptor subunit beta; inhibitory glycine receptor", "tax_id": 10090, "disease": "hyperekplexia 2 (Disease Ontology:DOID:0060697)", "pathway": " (mmu:14658); (R-MMU-112314)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12809985;16672662;17145751;19723286;21750661;21829170;22592841;25955356;30899004;33300544;35820727;7920630;7946325", "class_list": "", "function": "A species-specific thymine-to-guanine sequence variation in the Glrb gene has been identified which gives rise to species-specific splice donor sites in the Glrb genes of mouse and bushbaby. Publication Status: Online-Only, [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:12809985, PubMed:16672662)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. This gene is transcribed throughout the central nervous system of neonatal and adult mice. In humans, mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]; Transcripts are detected in cerebral cortex, liver, and heart. Lack of exon 7 results in a profoundly altered prediction of transmembrane topology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U5X3", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0044877 protein-containing complex binding;GO:0016594 glycine binding", "go_cellular_component": "GO:0016935 glycine-gated chloride channel complex;GO:0098982 GABA-ergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0001964 startle response;GO:0060012 synaptic transmission, glycinergic;GO:0006811 monoatomic ion transport;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P48168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R0H7-1", "uniprot_id": "GNAS1_MOUSE", "mass": 121505.0, "length": 1133, "protein_name": "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "gene_name": "Gnas", "organism": "Mouse", "refseq_name": "protein GNAS isoform XLas", "refseq_ac": "NP_034439", "gene_names_uniprotkb": "Gnas; Gnas1; MNCb-5546", "gene_names_refseq": "5530400H20Rik; A930027G11Rik; C130027O20Rik; GPSA; GSP; Galphas; Gnas1; Gnasxl; Gnas; Gs-alpha; Gsa; Nesp55; Nespl; Nesp; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; 3.6.5.-; Adenylate cyclase-stimulating G alpha protein; Extra large alphas protein; XLalphas", "protein_names_refseq": "GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; Gs alpha subunit; adenylate cyclase-stimulating G alpha protein; alternative gene product encoded by XL-exon; extra large alphas protein; neuroendocrine secretory protein 55; protein ALEX; protein GNAS isoform XLas; secretogranin VI; stimulatory G-protein alpha subunit", "tax_id": 10090, "disease": "pseudohypoparathyroidism type 1C (Disease Ontology:DOID:0051013); pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222); polycystic kidney disease (Disease Ontology:DOID:0080322); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); ACTH-independent macronodular adrenal hyperplasia 1 (Disease Ontology:DOID:0111623); pituitary adenoma 3 (Disease Ontology:DOID:0112010); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pancreatic cancer (Disease Ontology:DOID:1793); McCune Albright syndrome (Disease Ontology:DOID:1858); pseudopseudohypoparathyroidism (Disease Ontology:DOID:4183); pseudohypoparathyroidism (Disease Ontology:DOID:4184); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14683); (R-MMU-381676); (R-MMU-392851); (R-MMU-418555); (R-MMU-420092); (R-MMU-432040); (R-MMU-9634597); (R-MMU-9856530)", "pathway_count": 8, "publication_count": 22, "publication_id_list": "10097123;10610704;10716699;10749992;10931851;12145344;15148396;15798190;21467038;21750661;22645316;23994616;25428506;2826231;3092218;33300544;34203471;34428180;36288343;40997131;8227063;9860993", "class_list": "", "function": "Data report that the XL exon of Gsalpha is longer than presumed and contributes an additional 364 codons to XLalphas., [RefSeq, PubMed]; Gnas gene exhibits a complex imprinted pattern, giving rise to transcripts that are maternally, paternally, or biallelically expressed., [RefSeq, PubMed]; Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation. Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP., [UniProtKB, UniProtKB]; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Maternally expressed Nesp55 plays a role in controlling exploratory behavior., [RefSeq, PubMed]; May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame., [UniProtKB, UniProtKB]; This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2A607;A2A608;Q6R0H4;Q6R0H5;Q6R2J5;Q9JJX0;Q9Z1N8", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0010856 adenylate cyclase activator activity;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005834 heterotrimeric G-protein complex;GO:0005634 nucleus;GO:0005768 endosome", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis;GO:0071107 response to parathyroid hormone", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q6R0H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UVX5-1", "uniprot_id": "GRM5_MOUSE", "mass": 131865.0, "length": 1203, "protein_name": "Metabotropic glutamate receptor 5", "gene_name": "Grm5", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 5 isoform b precursor", "refseq_ac": "NP_001137306", "gene_names_uniprotkb": "Grm5; Gprc1e; Mglur5", "gene_names_refseq": "6430542K11Rik; Glu5R; Gprc1e; Grm5; mGluR5b; mGluR5", "protein_names_uniprotkb": "Metabotropic glutamate receptor 5; mGluR5", "protein_names_refseq": "G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; metabotropic glutamate receptor 5 isoform b precursor; metabotropic glutamate receptor 5; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:108071); (R-MMU-416476); (R-MMU-420499); (R-MMU-6794361)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22645316;24129315;30899004;32848054;33300544;34678516;35822049;40021952;40885482", "class_list": "", "function": "G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity (By similarity)., [UniProtKB]; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 9, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001639 PLC activating G protein-coupled glutamate receptor activity;GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0035106 operant conditioning;GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:1900039 positive regulation of cellular response to hypoxia;GO:0001659 temperature homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q3UVX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61598-1", "uniprot_id": "GDIB_MOUSE", "mass": 50537.0, "length": 445, "protein_name": "Rab GDP dissociation inhibitor beta", "gene_name": "Gdi2", "organism": "Mouse", "refseq_name": "rab GDP dissociation inhibitor beta", "refseq_ac": "NP_032138", "gene_names_uniprotkb": "Gdi2; Gdi3", "gene_names_refseq": "GDI-B; GDIB; Gdi2; Gdi3", "protein_names_uniprotkb": "Rab GDP dissociation inhibitor beta; GDI-2; GDI-3; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta", "protein_names_refseq": "GDI-2; GDI-3; RAB GDP dissociation inhibitor beta-2; guanosine diphosphate (GDP) dissociation inhibitor 2; guanosine diphosphate (GDP) dissociation inhibitor 3; guanosine diphosphate dissociation inhibitor 2; rab GDI beta; rab GDP dissociation inhibitor beta", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:14569); (R-MMU-6798695); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "11871104;21750661;22645316;23806337;25605945;25860027;26740625;31219806;33300544;34428180;35689892;36210013;36288343;37453647;37507081;37828378;38382624;39627609;39927985;7782346", "class_list": "", "function": "GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease., [RefSeq, PubMed]; GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP., [UniProtKB, UniProtKB, UniProtKB]; Role in regulatory mechanism of neurotransmitter release Review article, [RefSeq, PubMed]; Targeted disruption of Gdi2 causes early embryonic lethality., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541Z9;Q8C530;Q9D8M9", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005093 Rab GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0043209 myelin sheath;GO:0045202 synapse", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:1903565 negative regulation of protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61598-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61603-1", "uniprot_id": "GLRA4_MOUSE", "mass": 52514.0, "length": 456, "protein_name": "Glycine receptor subunit alpha-4", "gene_name": "Glra4", "organism": "Mouse", "refseq_name": "glycine receptor subunit alpha-4 isoform 1 precursor", "refseq_ac": "NP_034427", "gene_names_uniprotkb": "Glra4", "gene_names_refseq": "Glra4", "protein_names_uniprotkb": "Glycine receptor subunit alpha-4", "protein_names_refseq": "glycine receptor subunit alpha-4 isoform 1 precursor; glycine receptor subunit alpha-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:14657)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10762330;17154252;21850450;22592841;25428506;7507926", "class_list": "", "function": "Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:10762330). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (Probable)., [UniProtKB, PubMed]; The alpha4 subunit was localized in the inner plexiform layer (IPL) in brightly fluorescent puncta, which represent postsynaptically clustered glycine receptors., [RefSeq, PubMed]; The distinct developmental regulation of GlyRalpha4 in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AEA9;Q45V76;Q8VHF3", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0016594 glycine binding;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0034707 chloride channel complex;GO:0098690 glycinergic synapse", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61603-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64018-1", "uniprot_id": "GLRA1_MOUSE", "mass": 52657.0, "length": 457, "protein_name": "Glycine receptor subunit alpha-1", "gene_name": "Glra1", "organism": "Mouse", "refseq_name": "glycine receptor subunit alpha-1 isoform 1 precursor", "refseq_ac": "NP_001277750", "gene_names_uniprotkb": "Glra1", "gene_names_refseq": "Glra1; nmf11; oscillator; ot; spasmodic; spd", "protein_names_uniprotkb": "Glycine receptor subunit alpha-1; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit", "protein_names_refseq": "glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1 isoform 1 precursor; glycine receptor subunit alpha-1", "tax_id": 10090, "disease": "hyperekplexia (Disease Ontology:DOID:0060695); hyperekplexia 1 (Disease Ontology:DOID:0060696)", "pathway": " (mmu:14654); (R-MMU-112314)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12975813;16672662;17114051;21750661;24801766;36175550;7507926;7874121;7920629;9145798", "class_list": "", "function": "Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice., [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (PubMed:16672662, PubMed:17114051, PubMed:24801766). Plays an important role in the down-regulation of neuronal excitability (PubMed:9145798). Contributes to the generation of inhibitory postsynaptic currents (PubMed:16672662, PubMed:17114051, PubMed:24801766). Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (PubMed:24801766)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCT8;Q64019;Q9R0Y6;Q9R0Y7", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0030977 taurine binding;GO:0004888 transmembrane signaling receptor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016935 glycine-gated chloride channel complex;GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0001964 startle response;GO:0051970 negative regulation of transmission of nerve impulse;GO:0060012 synaptic transmission, glycinergic;GO:0097305 response to alcohol", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64018-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNC8-1", "uniprot_id": "GLRA2_MOUSE", "mass": 52062.0, "length": 452, "protein_name": "Glycine receptor subunit alpha-2", "gene_name": "Glra2", "organism": "Mouse", "refseq_name": "glycine receptor subunit alpha-2 isoform a precursor", "refseq_ac": "NP_906272", "gene_names_uniprotkb": "Glra2", "gene_names_refseq": "Glra2", "protein_names_uniprotkb": "Glycine receptor subunit alpha-2", "protein_names_refseq": "glycine receptor subunit alpha-2 isoform a precursor; glycine receptor subunit alpha-2", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Pilorge type (Disease Ontology:DOID:0070422)", "pathway": " (mmu:237213); (R-MMU-112314)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15329889;16847326;21924294;26370147;35396272", "class_list": "", "function": "GLRA2 gene mutations cause high myopia in humans and mice., [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (By similarity). Plays a role in synaptic plasticity (PubMed:26370147). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022852 glycine-gated chloride ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0016594 glycine binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection;GO:0098690 glycinergic synapse", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0034220 monoatomic ion transmembrane transport;GO:0071361 cellular response to ethanol;GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7TNC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XE0-1", "uniprot_id": "GLYAT_MOUSE", "mass": 34098.0, "length": 296, "protein_name": "Glycine N-acyltransferase", "gene_name": "Glyat", "organism": "Mouse", "refseq_name": "glycine N-acyltransferase", "refseq_ac": "NP_666047", "gene_names_uniprotkb": "Glyat", "gene_names_refseq": "A330009E03Rik; ACGNAT; CAT; GAT; Glyat", "protein_names_uniprotkb": "Glycine N-acyltransferase; 2.3.1.13; 2.3.1.71; AAc; Acyl-CoA:glycine N-acyltransferase; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase", "protein_names_refseq": "AAc; acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralkyl acyl-CoA:amino acid N-acyltransferase; benzoyl-coenzyme A:glycine N-acyltransferase; glycine N-acyltransferase; glycine N-benzoyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:107146); (R-MMU-159424); (R-MMU-177128); (R-MMU-177135); (R-MMU-70895); (R-MMU-9749641)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "23576753;23806337;24576660;30084848;34428180;37453647", "class_list": "", "function": "Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid., [UniProtKB, UniProtKB]; Mouse glycine N-acyltransferase was successfully overexpressed and purified from Escherichia coli. Benzoyl-CoA and glycine were the substrates with the highest (kcat/Km)app values., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05DG2", "ec_number_list": "2.3.1.13;2.3.1.-;2.3.1.71", "go_molecular_function": "GO:0047962 glycine N-benzoyltransferase activity;GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009636 response to toxic substance;GO:0006544 glycine metabolic process;GO:0032787 monocarboxylic acid metabolic process;GO:1901787 benzoyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91XE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0T4-1", "uniprot_id": "KATL1_MOUSE", "mass": 55165.0, "length": 488, "protein_name": "Katanin p60 ATPase-containing subunit A-like 1", "gene_name": "Katnal1", "organism": "Mouse", "refseq_name": "katanin p60 ATPase-containing subunit A-like 1", "refseq_ac": "NP_705800", "gene_names_uniprotkb": "Katnal1", "gene_names_refseq": "Katnal1", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A-like 1; 5.6.1.1; Katanin p60 subunit A-like 1; p60 katanin-like 1", "protein_names_refseq": "katanin p60 ATPase-containing subunit A-like 1; p60 katanin-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231912)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;22654668;30448058;31219806;31485656;34203471;34428180;35979014;36210013;37882691", "class_list": "", "function": "Circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Katanin p60 ATPase-containing subunit A-like 1 was predominant in the ovaries and oocytes, indicating its essential roles in oocyte meiosis. It was also revealed that p60 kataninlike 1 was concentrated at the spindle poles and colocalized and interacted with gammatubulin, indicating that it may be involved in pole organization., [RefSeq, PubMed]; More active and more stable katanin subunit, KATNAL1, plays more important role in process elongation., [RefSeq, PubMed]; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (PubMed:22654668). Has microtubule-severing activity in vitro (By similarity)., [UniProtKB, UniProtKB, PubMed]; The identification of KATNAL1 as an essential regulator of male fertility provides a significant novel entry point into advancing our understanding of how SC microtubule dynamics promotes male fertility, [RefSeq, PubMed]; The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0008352 katanin complex;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0051013 microtubule severing;GO:0007283 spermatogenesis;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K0T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C605-1", "uniprot_id": "KGP1_MOUSE", "mass": 76350.0, "length": 671, "protein_name": "cGMP-dependent protein kinase 1", "gene_name": "Prkg1", "organism": "Mouse", "refseq_name": "cGMP-dependent protein kinase 1 isoform alpha", "refseq_ac": "NP_001013855", "gene_names_uniprotkb": "Prkg1; Prkg1b; Prkgr1a; Prkgr1b", "gene_names_refseq": "CGKI; Gm19690; Prkg1b; Prkg1; Prkgr1b", "protein_names_uniprotkb": "cGMP-dependent protein kinase 1; 2.7.11.12; cGK 1; cGK1; cGKI; cGMP-dependent protein kinase I", "protein_names_refseq": "cGK 1; cGK1; cGMP-dependent protein kinase 1 isoform alpha; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); hypertension (Disease Ontology:DOID:10763); thoracic aortic aneurysm (Disease Ontology:DOID:14004); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); hypogonadism (Disease Ontology:DOID:1924); allergic rhinitis (Disease Ontology:DOID:4481); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19091); (R-MMU-392517); (R-MMU-418457)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10085070;10209042;11055988;16154279;16990611;19156199;21183079;21750661;31219806;34428180;34863181;35820727;9606187;9920894", "class_list": "", "function": "Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14DK6;Q9Z0Z0", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004692 cGMP-dependent protein kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0016358 dendrite development;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0C605-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15388-1", "uniprot_id": "KCNC1_MOUSE", "mass": 57928.0, "length": 511, "protein_name": "Voltage-gated potassium channel KCNC1", "gene_name": "Kcnc1", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel KCNC1 isoform 2", "refseq_ac": "NP_032447", "gene_names_uniprotkb": "Kcnc1", "gene_names_refseq": "C230009H10Rik; KShIIIB; KV4; Kcnc1; Kcr2-1; Kv3.1; NGK2; Shaw", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC1; NGK2; Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4", "protein_names_refseq": "potassium voltage-gated channel subfamily C member 1; voltage-gated potassium channel KCNC1 isoform 2; voltage-gated potassium channel KCNC1; voltage-gated potassium channel subunit Kv3.1; voltage-gated potassium channel subunit Kv4", "tax_id": 10090, "disease": "progressive myoclonus epilepsy 7 (Disease Ontology:DOID:0111447)", "pathway": " (mmu:16502); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11517255;1400413;15217387;16923152;21183079;2599109;33300544;9037088", "class_list": "", "function": "Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient (PubMed:1400413, PubMed:2599109). The mechanism is time-dependent and inactivation is slow (PubMed:2599109). Plays an important role in the rapid repolarization of fast-firing brain neurons. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9PVV3", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding;GO:0019894 kinesin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0032589 neuron projection membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:1990089 response to nerve growth factor;GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P15388-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58391-1", "uniprot_id": "KCNN3_MOUSE", "mass": 81333.0, "length": 732, "protein_name": "Small conductance calcium-activated potassium channel protein 3", "gene_name": "Kcnn3", "organism": "Mouse", "refseq_name": "small conductance calcium-activated potassium channel protein 3", "refseq_ac": "NP_536714", "gene_names_uniprotkb": "Kcnn3; Sk3", "gene_names_refseq": "KCa2.3; Kcnn3; SK3; SKCA3", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 3; KCa2.3; SK3; SKCa 3; SKCa3", "protein_names_refseq": "SKCa 3; small conductance calcium-activated potassium channel 3; small conductance calcium-activated potassium channel protein 3", "tax_id": 10090, "disease": "paranoid schizophrenia (Disease Ontology:DOID:1229); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:140493); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11557517;12805243;12813145;12882916;16055520;20689065;21183079;22645316;30084848;36951065;38012158", "class_list": "", "function": "Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis., [RefSeq, PubMed]; Endothelial SK3 channels exert a profound, tonic, hyperpolarizing influence in resistance arteries and suggest that the level of SK3 channel expression in endothelial cells is a fundamental determinant of vascular tone and blood pressure, [RefSeq, PubMed]; SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion., [RefSeq, PubMed]; Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11557517). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens (PubMed:11557517). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; These channels have a significant role in the control of non-voiding contractions of the urinary bladder in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUY9", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0044877 protein-containing complex binding;GO:0016286 small conductance calcium-activated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body;GO:0030175 filopodium", "go_biological_process": "GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P58391-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P68181-1", "uniprot_id": "KAPCB_MOUSE", "mass": 40708.0, "length": 351, "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "Prkacb", "organism": "Mouse", "refseq_name": "cAMP-dependent protein kinase catalytic subunit beta isoform 2", "refseq_ac": "NP_001157670", "gene_names_uniprotkb": "Prkacb; Pkacb", "gene_names_refseq": "CbPKA; PKA C-beta; Pkacb; Prkacb", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit beta; 2.7.11.11; PKA C-beta", "protein_names_refseq": "Cbeta2 PKA; cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic subunit beta isoform 2; cAMP-dependent protein kinase catalytic subunit beta", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:18749); (R-MMU-163615); (R-MMU-164378); (R-MMU-180024); (R-MMU-381676); (R-MMU-392517); (R-MMU-422356); (R-MMU-432040); (R-MMU-4420097); (R-MMU-442720); (R-MMU-5610785); (R-MMU-5610787); (R-MMU-5621575); (R-MMU-5687128); (R-MMU-8853659); (R-MMU-8963896); (R-MMU-9634597); (R-MMU-983231); (R-MMU-9856530)", "pathway_count": 19, "publication_count": 11, "publication_id_list": "12106288;18034455;21750661;25428506;2833513;28973931;30084848;3023318;33300544;37828378;9368018", "class_list": "", "function": "Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (By similarity). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:9368018). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). Phosphorylates GPKOW which regulates its ability to bind RNA (By similarity). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (By similarity)., [UniProtKB, PubMed, UniProtKB]; Protein kinase A signaling explains vasopressin-mediated regulation of membrane trafficking and gene transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05206;Q3TQH5;Q3UDD0;Q3UTH5", "ec_number_list": "2.7.11.1;2.7.11.25;3.1.4.-;3.1.4.53;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.1;7.6.2.1;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;1.14.13.39;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0001843 neural tube closure;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P68181-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TTY5-1", "uniprot_id": "K22E_MOUSE", "mass": 70923.0, "length": 707, "protein_name": "Keratin, type II cytoskeletal 2 epidermal", "gene_name": "Krt2", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 2 epidermal", "refseq_ac": "NP_034798", "gene_names_uniprotkb": "Krt2; K2e; Krt2-17; Krt2a", "gene_names_refseq": "Krt2-17; Krt2-2; Krt2e; Krt2", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 2 epidermal; CK-2e; Cytokeratin-2e; Epithelial keratin-2e; K2e; Keratin-2 epidermis; Keratin-2e; Type-II keratin Kb2", "protein_names_refseq": "CK-2e; K2e; cytokeratin-2e; epithelial keratin-2e; keratin 2 epidermis; keratin complex 2, basic, gene 17; keratin complex 2, gene 17; keratin, type II cytoskeletal 2 epidermal; keratin-2e; type-II keratin Kb2", "tax_id": 10090, "disease": "bullous congenital ichthyosiform erythroderma (Disease Ontology:DOID:0060877); ichthyosis (Disease Ontology:DOID:1697)", "pathway": " (mmu:16681); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "12533510;15118396;20485683;22645316;24129315;2448177;24751727;26603179;34203471;34418053;34428180;34887587;36583994;37453647;39627609;40997131;41018975;7508961;9378767", "class_list": "", "function": "Structural component of intermediate filaments in suprabasal keratinocytes of stratified epidermis. Forms heteropolymers with type I keratins (e.g., KRT10), assembling into keratin intermediate filament networks that support epidermal differentiation and barrier integrity (PubMed:24751727, PubMed:26603179). Contributes to terminal differentiation and cornification of keratinocytes and plays a role in establishing the epidermal barrier, particularly in plantar (sole) skin and in the epidermis of the ear and tail (PubMed:24751727, PubMed:26603179)., [UniProtKB, PubMed, PubMed]; This study demonstrates that the loss of the main cytoskeletal components of plantar epidermis, i.e. K2 and K10, can be only partly compensated by the upregulation of other keratins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 23, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 23, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 23, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBW1;Q61869", "ec_number_list": "", "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045111 intermediate filament cytoskeleton;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0032980 keratinocyte activation;GO:0051546 keratinocyte migration;GO:0031424 keratinization;GO:0008544 epidermis development;GO:0003334 keratinocyte development", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q3TTY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q562E2-1", "uniprot_id": "KCD19_MOUSE", "mass": 104820.0, "length": 927, "protein_name": "BTB/POZ domain-containing protein KCTD19", "gene_name": "Kctd19", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD19 isoform 2", "refseq_ac": "NP_001288102", "gene_names_uniprotkb": "Kctd19", "gene_names_refseq": "4922504H04Rik; Kctd19", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD19", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD19 isoform 2; BTB/POZ domain-containing protein KCTD19", "tax_id": 10090, "disease": "", "pathway": " (mmu:279499)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18849567;21183079;21750661;25428506;33961623;34075040;35341968;37192818;37257643;37921559", "class_list": "", "function": "Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia., [RefSeq, PubMed]; Homozygous nonsense variants of KCTD19 cause male infertility in humans and mice., [RefSeq, PubMed]; KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes (PubMed:33961623, PubMed:34075040, PubMed:35341968). Regulates progression of the pachytene stage of meiotic prophase and promotes the transcriptional activation activity ZNF541 (PubMed:35341968). Required for the organization of chromosomes during metaphase I (PubMed:33961623, PubMed:34075040)., [UniProtKB, PubMed, PubMed, PubMed]; ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C628", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051260 protein homooligomerization;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q562E2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VJ8-1", "uniprot_id": "KASH5_MOUSE", "mass": 72444.0, "length": 648, "protein_name": "Protein KASH5", "gene_name": "Kash5", "organism": "Mouse", "refseq_name": "protein KASH5", "refseq_ac": "NP_958762", "gene_names_uniprotkb": "Kash5; Ccdc155", "gene_names_refseq": "Ccdc155; Gm1434; Kash5", "protein_names_uniprotkb": "Protein KASH5; Coiled-coil domain-containing protein 155; KASH domain-containing protein 5", "protein_names_refseq": "KASH domain-containing protein 5; coiled-coil domain containing 155; coiled-coil domain-containing protein 155; protein KASH5", "tax_id": 10090, "disease": "spermatogenic failure 88 (Disease Ontology:DOID:0070587); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:384619)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "22826121;24062341;24586178;25380821;25892231;26842404;35674372;35708642", "class_list": "", "function": "Ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome., [RefSeq, PubMed]; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation., [UniProtKB, PubMed, PubMed, PubMed]; Homozygous Variant in KASH5 Causes Premature Ovarian Insufficiency by Disordered Meiotic Homologous Pairing., [RefSeq, PubMed]; It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex., [RefSeq, PubMed]; Novel bi-allelic variants in KASH5 are associated with meiotic arrest and non-obstructive azoospermia., [RefSeq, PubMed]; Results provide evidence that SUN1 and KASH5 are essential factors in the regulation of meiotic resumption and spindle formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNS3;E9QQ69", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0090619 meiotic spindle pole;GO:0005640 nuclear outer membrane;GO:0000800 lateral element;GO:0000781 chromosome, telomeric region;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation;GO:0007015 actin filament organization;GO:0007283 spermatogenesis;GO:0000724 double-strand break repair via homologous recombination;GO:0051653 spindle localization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80VJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z351-1", "uniprot_id": "KCNQ2_MOUSE", "mass": 84450.0, "length": 759, "protein_name": "Potassium voltage-gated channel subfamily KQT member 2", "gene_name": "Kcnq2", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily KQT member 2 isoform 6", "refseq_ac": "NP_001006675", "gene_names_uniprotkb": "Kcnq2; Kqt2", "gene_names_refseq": "HNSPC; KQT2; Kcnq2; Nmf134", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2", "protein_names_refseq": "KQT-like 2; potassium channel subunit alpha KvLQT2; potassium voltage-gated channel subfamily KQT member 2 isoform 6; potassium voltage-gated channel subfamily KQT member 2; voltage-gated potassium channel subunit Kv7.2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); heart conduction disease (Disease Ontology:DOID:10273); benign neonatal seizures (Disease Ontology:DOID:14264); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:16536)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10854243;12223552;16452087;21183079;21750661;27979964;30059200;38052789;38440182;9666519", "class_list": "", "function": "Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:12223552). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:12223552). M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTI0;Q8R498;Q9QWN9;Q9Z342;Q9Z343;Q9Z344;Q9Z345;Q9Z346;Q9Z347;Q9Z348;Q9Z349;Q9Z350", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005267 potassium channel activity;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0030506 ankyrin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1903701 substantia propria of cornea development;GO:0098976 excitatory chemical synaptic transmission;GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35082-1", "uniprot_id": "KLOT_MOUSE", "mass": 116398.0, "length": 1014, "protein_name": "Klotho", "gene_name": "Kl", "organism": "Mouse", "refseq_name": "klotho precursor", "refseq_ac": "NP_038851", "gene_names_uniprotkb": "Kl", "gene_names_refseq": "Kl; alpha-kl", "protein_names_uniprotkb": "Klotho; 3.2.1.31", "protein_names_refseq": "klotho precursor; secreted form of Klotho protein", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); hyperphosphatemic familial tumoral calcinosis (Disease Ontology:DOID:0111063); retinitis pigmentosa (Disease Ontology:DOID:10584); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); secondary hyperparathyroidism (Disease Ontology:DOID:12466); spondylosis (Disease Ontology:DOID:2247); coronary artery disease (Disease Ontology:DOID:3393); intracranial embolism (Disease Ontology:DOID:4372); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:16591); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190374); (R-MMU-5654219); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654726); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 12, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10631108;11016890;11095966;11411791;12204354;14528024;14701853;15135068;15485693;15665504;16123266;17086194;17114649;35820727;39094831;39277686;9363890;9537505", "class_list": "glycogene;glycosylhydrolase", "function": "Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes (PubMed:14701853). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (PubMed:14701853). Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis (PubMed:17086194)., [UniProtKB, PubMed, PubMed]; Sex-dependent changes in AMPAR expression and Na, K-ATPase activity in the cerebellum and hippocampus of alpha-Klotho-Hypomorphic mice., [RefSeq, PubMed]; Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b. Publication Status: Online-Only, [RefSeq, PubMed]; The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 61, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 15, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2RR78;O70175;O70621", "ec_number_list": "3.2.1.31;2.7.1.153;2.7.1.137;2.7.10.2;2.7.10.1;3.6.5.2;2.7.11.17;3.2.2.6;3.1.3.48;2.3.2.27;2.7.11.1;2.7.11.24;3.1.4.11;2.7.1.154", "go_molecular_function": "GO:0017134 fibroblast growth factor binding;GO:0004566 beta-glucuronidase activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0005975 carbohydrate metabolic process;GO:0006112 energy reserve metabolic process;GO:0014823 response to activity;GO:0030501 positive regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O35082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61166-1", "uniprot_id": "MARE1_MOUSE", "mass": 30016.0, "length": 268, "protein_name": "Microtubule-associated protein RP/EB family member 1", "gene_name": "Mapre1", "organism": "Mouse", "refseq_name": "microtubule-associated protein RP/EB family member 1", "refseq_ac": "NP_031922", "gene_names_uniprotkb": "Mapre1", "gene_names_refseq": "5530600P05Rik; BIM1p; D2Ertd459e; Eb1; Mapre1", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 1; APC-binding protein EB1; EB1; End-binding protein 1", "protein_names_refseq": "APC-binding protein EB1; adenomatosis polyposis coli binding protein Eb1; end-binding protein 1; microtubule-associated protein RP/EB family member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13589); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8854518); (R-MMU-9648025)", "pathway_count": 16, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15311282;18854161;19553473;21357749;21646404;23055941;24706950;30787442;32755434;34092082;37074918", "class_list": "", "function": "Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth., [RefSeq, PubMed]; Photo-Excited Toluidine Blue Disaggregates the Repeat Tau and Modulates End-Binding Protein EB1, Cytoskeletal Structure in Neuronal Cells., [RefSeq, PubMed]; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (PubMed:15311282). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with DSP, thereby facilitating gap junction intracellular communication (By similarity). May play a role in cell migration (PubMed:15311282)., [UniProtKB, UniProtKB, PubMed]; Results show an evolutionarily conserved pathway for microtubule capture, and suggest that mDia functions as a scaffold protein for EB1 and APC to stabilize microtubules and promote cell migration., [RefSeq, PubMed]; Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN34", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0030981 cortical microtubule cytoskeleton;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005925 focal adhesion", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0046785 microtubule polymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0016477 cell migration;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UQN2-1", "uniprot_id": "FCHO2_MOUSE", "mass": 88734.0, "length": 809, "protein_name": "F-BAR domain only protein 2", "gene_name": "Fcho2", "organism": "Mouse", "refseq_name": "F-BAR domain only protein 2", "refseq_ac": "NP_766179", "gene_names_uniprotkb": "Fcho2", "gene_names_refseq": "5832424M12Rik; Fcho2", "protein_names_uniprotkb": "F-BAR domain only protein 2", "protein_names_refseq": "F-BAR domain only protein 2; FCH domain only protein 2", "tax_id": 10090, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894)", "pathway": " (mmu:218503); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;20448150;21183079;21750661;21762413;21883765;22323290;22517741;25428506;31219806;34428180;35822049;36210013;36852467;37828378;40885482", "class_list": "", "function": "FCHO2 regulates clathrin-mediated endocytosis through its interactions with membranes and Eps15., [RefSeq, PubMed]; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor., [UniProtKB, PubMed, PubMed]; Study reports FCHo1/2 were required for plasma membrane clathrin-coated vesicle (CCV) budding & marked sites of CCV formation Erratum:[Science. 2025 Nov 13;390(6774):eaed1654. doi: 10.1126/science.aed1654. PMID: 41232007], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJ91;Q7TMS9;Q8C0I2", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0001786 phosphatidylserine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0045202 synapse;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0010324 membrane invagination;GO:0072659 protein localization to plasma membrane;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q3UQN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLM8-1", "uniprot_id": "DCLK1_MOUSE", "mass": 84153.0, "length": 756, "protein_name": "Serine/threonine-protein kinase DCLK1", "gene_name": "Dclk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase DCLK1 isoform 1", "refseq_ac": "NP_064362", "gene_names_uniprotkb": "Dclk1; Dcamkl1; Dclk", "gene_names_refseq": "1700113D08Rik; 2810480F11Rik; Click-I; Cpg16; Dcamkl1; Dclk1; Dclk; Dcl; mKIAA0369", "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK1; 2.7.11.1; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1", "protein_names_refseq": "CLICK-I beta; doublecortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin-like and CAM kinase-like 1; serine/threonine-protein kinase DCLK1 isoform 1; serine/threonine-protein kinase DCLK1", "tax_id": 10090, "disease": "dyslexia (Disease Ontology:DOID:4428)", "pathway": " (mmu:13175)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10533048;11473121;15345747;16452087;18034455;19131326;21183079;21750661;22645316;25153642;33300544;39174821", "class_list": "", "function": "DCLK is a physiological substrate for the cysteine protease calpain. In neurons cleavage of DCLK by calpain represents a calcium responsive mechanism to regulate localization of the DCLK kinase domain, [RefSeq, PubMed]; Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P207", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0030900 forebrain development;GO:0035556 intracellular signal transduction;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JLM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13020-1", "uniprot_id": "GELS_MOUSE", "mass": 85942.0, "length": 780, "protein_name": "Gelsolin", "gene_name": "Gsn", "organism": "Mouse", "refseq_name": "gelsolin isoform 1 precursor", "refseq_ac": "NP_666232", "gene_names_uniprotkb": "Gsn; Gsb", "gene_names_refseq": "ADF; Gsn", "protein_names_uniprotkb": "Gelsolin; ADF; Actin-depolymerizing factor; Brevin", "protein_names_refseq": "actin-depolymerizing factor; brevin; gelsolin isoform 1 precursor", "tax_id": 10090, "disease": "Finnish type amyloidosis (Disease Ontology:DOID:0050637); pre-eclampsia (Disease Ontology:DOID:10591); hypothyroidism (Disease Ontology:DOID:1459); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); rheumatic myocarditis (Disease Ontology:DOID:8481); lung disease (Disease Ontology:DOID:850); gas gangrene (Disease Ontology:DOID:9159)", "pathway": " (mmu:227753); (R-MMU-264870); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "12742020;21750661;22633459;22645316;23806337;24743229;2546951;26495903;26740625;28695858;31199804;31209405;34428180;34887587;35984892;36288343;36522181;36583994;37126682;37507081;37828378;38777258;39627609;7523108", "class_list": "", "function": "Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis via the Actin Cytoskeleton., [RefSeq, PubMed]; Gelsolin regulates receptor-mediated and fluid-phase endocytosis in platelets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPB1;Q8R590", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0014891 striated muscle atrophy;GO:0071801 regulation of podosome assembly;GO:0097017 renal protein absorption;GO:1902174 positive regulation of keratinocyte apoptotic process;GO:1903903 regulation of establishment of T cell polarity", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P13020-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00860-1", "uniprot_id": "DCOR_MOUSE", "mass": 51177.0, "length": 461, "protein_name": "Ornithine decarboxylase", "gene_name": "Odc1", "organism": "Mouse", "refseq_name": "ornithine decarboxylase isoform 1", "refseq_ac": "NP_038642", "gene_names_uniprotkb": "Odc1; Odc", "gene_names_refseq": "ODC; Odc1", "protein_names_uniprotkb": "Ornithine decarboxylase; 4.1.1.17; ODC", "protein_names_refseq": "ornithine decarboxylase isoform 1", "tax_id": 10090, "disease": "atrichia with papular lesions (Disease Ontology:DOID:0060689)", "pathway": " (mmu:18263); (R-MMU-350562); (R-MMU-351202)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10378276;1730582;18973822;2026163;21750661;24967154;2982844;30084848;31219806;3362685;3372502;34428180;3456155;38216963;3856848;8106349;8243470;8350350;8504104", "class_list": "", "function": "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61997;Q61998;Q6PB87", "ec_number_list": "3.4.19.12;3.4.25.1;4.1.1.17;1.6.5.2", "go_molecular_function": "GO:0004586 ornithine decarboxylase activity;GO:0042803 protein homodimerization activity;GO:0042978 ornithine decarboxylase activator activity;GO:0003824 catalytic activity;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0001822 kidney development;GO:0009615 response to virus;GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P00860-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UJB9-1", "uniprot_id": "EDC4_MOUSE", "mass": 152484.0, "length": 1406, "protein_name": "Enhancer of mRNA-decapping protein 4", "gene_name": "Edc4", "organism": "Mouse", "refseq_name": "enhancer of mRNA-decapping protein 4 isoform 1", "refseq_ac": "NP_001288029", "gene_names_uniprotkb": "Edc4", "gene_names_refseq": "Edc4", "protein_names_uniprotkb": "Enhancer of mRNA-decapping protein 4", "protein_names_refseq": "enhancer of mRNA-decapping protein 4 isoform 1; enhancer of mRNA-decapping protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:234699); (R-MMU-430039)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16314453;17242355;19144319;20639877;21183079;21750661;22645316;23583643;28135057;28254886;28528544;31219806;31599954;34428180;39627609;40997131;7520377", "class_list": "", "function": "Ge-1, the human ortholog of mouse Edc4, was shown to localize to mRNA processing bodies (P-body)in a human cell line. The C-terminal region is required for this localization., [RefSeq, PubMed]; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The human Ge-1 gene (also known as Hedls and Edc4)is an ortholog of mouse Edc4. The gene was identified by screening a cDNA expression library using serum from a patient with Sjogren's syndrome., [RefSeq, PubMed]; The protein encoded by this gene is thought to promote mRNA decay, and is known to interact with several mRNA decapping proteins. In humans, decreased expression of this gene prevents the accumulation of mRNA decapping proteins to mRNA processing bodies (P-body). Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6U8;Q7TS78;Q8R223", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005737 cytoplasm", "go_biological_process": "GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q3UJB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDQ2-1", "uniprot_id": "CHD4_MOUSE", "mass": 217751.0, "length": 1915, "protein_name": "ATP-dependent chromatin remodeler CHD4", "gene_name": "Chd4", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD4 isoform g", "refseq_ac": "NP_001333539", "gene_names_uniprotkb": "Chd4", "gene_names_refseq": "9530019N15Rik; Chd4; D6Ertd380e; Mi-2beta; mKIAA4075", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD4; 3.6.4.-; CHD-4; Chromo domain-containing protein 4", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD4 isoform g; ATP-dependent chromatin remodeler CHD4; CHD-4; Mi-2 beta; chromo domain-containing protein 4", "tax_id": 10090, "disease": "lymphoma (Disease Ontology:DOID:0060058); left ventricular noncompaction (Disease Ontology:DOID:0060480); Sifrim-Hitz-Weiss syndrome (Disease Ontology:DOID:0070529); lung cancer (Disease Ontology:DOID:1324); rectum cancer (Disease Ontology:DOID:1993); colon adenocarcinoma (Disease Ontology:DOID:234); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:107932); (R-MMU-3214815); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9031628); (R-MMU-9937850); (R-MMU-9940465); (R-MMU-9940951)", "pathway_count": 9, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11003653;17242355;17938210;19144319;21183079;21750661;22645316;25428506;25605945;27806305;29187734;30084848;30228260;30327463;30779550;34203471;34428180;36852467;39627609", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:17938210). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (By similarity). Involved in neurogenesis (PubMed:27806305)., [UniProtKB, UniProtKB, PubMed, PubMed]; ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;2.3.1.48;2.3.1.-;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;3.5.1.-;3.5.1.98;7.6.2.1;3.6.1.5;2.1.1.37;2.1.1.-;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;1.14.11.-;1.14.11.65;1.14.99.66;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;2.1.1.367;1.21.99.4", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000785 chromatin", "go_biological_process": "GO:0072553 terminal button organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q6PDQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXS4-1", "uniprot_id": "CENPV_MOUSE", "mass": 27541.0, "length": 252, "protein_name": "Centromere protein V", "gene_name": "Cenpv", "organism": "Mouse", "refseq_name": "centromere protein V", "refseq_ac": "NP_082724", "gene_names_uniprotkb": "Cenpv; Prr6", "gene_names_refseq": "3110013H01Rik; Cenpv; Prr6", "protein_names_uniprotkb": "Centromere protein V; CENP-V; Proline-rich protein 6", "protein_names_refseq": "CENP-V; centromere protein V; proline-rich polypeptide 6; proline-rich protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:73139)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;24129315;33300544;37453647;39927985", "class_list": "", "function": "Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RWK8;B9EK22;Q5SX21;Q6PIA5", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0016846 carbon-sulfur lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0051382 kinetochore assembly;GO:0031508 pericentric heterochromatin formation;GO:0007059 chromosome segregation;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CXS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q09XV5-1", "uniprot_id": "CHD8_MOUSE", "mass": 290847.0, "length": 2582, "protein_name": "ATP-dependent chromatin remodeler CHD8", "gene_name": "Chd8", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD8", "refseq_ac": "NP_963999", "gene_names_uniprotkb": "Chd8; Kiaa1564", "gene_names_refseq": "5830451P18Rik; Chd-8; Chd8; Duplin; HELSNF1; mKIAA1564", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD8; 3.6.4.-; Axis duplication inhibitor; CHD-8; Chromo domain-containing protein 8; Duplin", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD8; ATP-dependent helicase CHD8; axis duplication inhibitor; chromo domain-containing protein 8; helicase with SNF2 domain 1", "tax_id": 10090, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:67772); (R-MMU-3769402); (R-MMU-9943962)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;15367660;16949368;19144319;19151705;21183079;21750661;22645316;25428506;25605945;30084848;30779550;32782141;34203471;34428180;35820727;36537238;36852467;38560770;40885482;40997131", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL., [UniProtKB, PubMed, PubMed, HAMAP, PubMed]; Chd8 haploinsufficiency impacts rearing experience in C57BL/6 mice., [RefSeq, PubMed]; This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene causes early embryonic lethality due to widespread apoptosis. Heterozygous loss of function mutations result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV89;Q5I1Z2;Q6ZPM8", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0071339 MLL1 complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001964 startle response;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q09XV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1T5-1", "uniprot_id": "DEAF1_MOUSE", "mass": 59633.0, "length": 566, "protein_name": "Deformed epidermal autoregulatory factor 1 homolog", "gene_name": "Deaf1", "organism": "Mouse", "refseq_name": "deformed epidermal autoregulatory factor 1 homolog isoform 1", "refseq_ac": "NP_058570", "gene_names_uniprotkb": "Deaf1", "gene_names_refseq": "C230009B13Rik; Deaf1; NUDR", "protein_names_uniprotkb": "Deformed epidermal autoregulatory factor 1 homolog; NUDR; Nuclear DEAF-1-related transcriptional regulator", "protein_names_refseq": "deformed epidermal autoregulatory factor 1 homolog isoform 1; deformed epidermal autoregulatory factor 1 homolog; nuclear DEAF-1-related transcriptional regulator; suppressin", "tax_id": 10090, "disease": "Vulto-van Silfout-de Vries syndrome (Disease Ontology:DOID:0070054)", "pathway": " (mmu:54006)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14966286;18826651;19668219;21183079;21750661;22723967;24726472;25428506;30059200;31145909;31783086;35981081;40997131;9860983", "class_list": "", "function": "Data indicate an important role for LMO4 and Deaf-1 in pathways affecting neural tube closure and skeletal patterning, most likely reflecting their presence in a functional complex in vivo., [RefSeq, PubMed]; Expansion and mechanistic insights into de novo DEAF1 variants in DEAF1-associated neurodevelopmental disorders., [RefSeq, PubMed]; Impaired memory and marble burying activity in deformed epidermal autoregulatory factor 1 (Deaf1) conditional knockout mice., [RefSeq, PubMed]; Lower peripheral tissue antigens (PTA) expression resulting from the alternative splicing of DEAF1 may contribute to the pathogenesis of type 1 diabetes., [RefSeq, PubMed]; This study shows that Deaf1 promotes eccrine gland formation, [RefSeq, PubMed]; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3 (By similarity). May also involved in behavior (PubMed:24726472)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "C7SHZ9;Q3UJA4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008542 visual learning;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z1T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJK6-1", "uniprot_id": "CHD7_MOUSE", "mass": 334061.0, "length": 2986, "protein_name": "ATP-dependent chromatin remodeler CHD7", "gene_name": "Chd7", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD7 isoform 1", "refseq_ac": "NP_001264078", "gene_names_uniprotkb": "Chd7", "gene_names_refseq": "A730019I05Rik; Chd7; Cycn; Cyn; Dz; Edy; Flo; GENA 47; GENA 60; Gena 52; Lda; Mt; Obt; Todo; WBE1; Whi; metis", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD7; 3.6.4.-; CHD-7; Chromo domain-containing protein 7", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD7 isoform 1; ATP-dependent chromatin remodeler CHD7; ATP-dependent helicase CHD7; chromo domain-containing protein 7", "tax_id": 10090, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); hypogonadotropic hypogonadism 5 with or without anosmia (Disease Ontology:DOID:0090084); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:320790); (R-MMU-9943962)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16400610;20507341;21750661;24129315;25605945;29311329;34428180;35820727", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a protein containing two chromodomains and an ATP-binding helicase domain that functions as a regulator of transcription. Mutations in this gene result in an array of development defects, including inner ear problems. Mice defective for this gene exhibit many of the clinical features of the CHARGE syndrome caused by mutations in the homologous gene in human. [provided by RefSeq, Sep 2015]., [RefSeq]; [review] recent and ongoing analyses of CHD7 function in mouse models and cell-based systems Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA86;Q3TAG7;Q3TBU4;Q8C986;Q8K244", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0003226 right ventricular compact myocardium morphogenesis;GO:0021545 cranial nerve development;GO:0021553 olfactory nerve development;GO:0030540 female genitalia development;GO:0036302 atrioventricular canal development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2AJK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PNC0-1", "uniprot_id": "DMXL1_MOUSE", "mass": 336008.0, "length": 3013, "protein_name": "DmX-like protein 1", "gene_name": "Dmxl1", "organism": "Mouse", "refseq_name": "dmX-like protein 1", "refseq_ac": "NP_001074840", "gene_names_uniprotkb": "Dmxl1", "gene_names_refseq": "C630007L23Rik; D030030C22; Dmxl1", "protein_names_uniprotkb": "DmX-like protein 1; X-like 1 protein", "protein_names_refseq": "X-like 1 protein; dmX-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:240283)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;20173027;21183079;21750661;22872234;25428506;30084848;30779550;31219806;34203471;34428180;35820727;36210013", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLG8;Q6PHM6;Q8BQF2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043291 RAVE complex", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0007035 vacuolar acidification;GO:0070070 proton-transporting V-type ATPase complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6PNC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YE7-1", "uniprot_id": "DAPK1_MOUSE", "mass": 161442.0, "length": 1442, "protein_name": "Death-associated protein kinase 1", "gene_name": "Dapk1", "organism": "Mouse", "refseq_name": "death-associated protein kinase 1 isoform 2", "refseq_ac": "NP_001272846", "gene_names_uniprotkb": "Dapk1", "gene_names_refseq": "D13Ucla1; DAP-Kinase; Dapk1", "protein_names_uniprotkb": "Death-associated protein kinase 1; 2.7.11.1; DAP kinase 1", "protein_names_refseq": "DAP kinase 1; death-associated protein kinase 1 isoform 2", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); uterine fibroid (Disease Ontology:DOID:13223)", "pathway": " (mmu:69635)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11485996;14530257;15729359;17242355;18806755;20141836;21183079;21750661;23071094;25605945;30016717;31219806;33052227;33250715;34428180;37775722;38851140", "class_list": "", "function": "Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3 (By similarity). Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Cellular activities of DAPK are critical for antagonizing caspase-dependent apoptosis to promote cell survival under normal cell growth conditions., [RefSeq, PubMed]; Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke., [RefSeq, PubMed]; Quantitative Proteomic and Phosphoproteomic Analyses Reveal a Role of Death-Associated Protein Kinase 1 in Regulating Hippocampal Synapse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80YE6;Q8R341;Q8VDN6;Q9CSD4;Q9JJP7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:2000310 regulation of NMDA receptor activity", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q80YE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R5F8-1", "uniprot_id": "ES8L1_MOUSE", "mass": 80028.0, "length": 716, "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 1", "gene_name": "Eps8l1", "organism": "Mouse", "refseq_name": "epidermal growth factor receptor kinase substrate 8-like protein 1 isoform 1", "refseq_ac": "NP_001277345", "gene_names_uniprotkb": "Eps8l1; Eps8r1", "gene_names_refseq": "2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1; Eps8l1", "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8-like protein 1; EPS8-like protein 1; EPS8-related protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1", "protein_names_refseq": "EPS8-like protein 1; EPS8-related protein 1; epidermal growth factor receptor kinase substrate 8-like protein 1 isoform 1; epidermal growth factor receptor kinase substrate 8-like protein 1; epidermal growth factor receptor pathway substrate 8-related protein 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:67425)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12620401;14565974;21183079;21750661;30084848", "class_list": "", "function": "Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0D6;Q9D2M6", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0042608 T cell receptor binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032587 ruffle membrane;GO:0001726 ruffle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0016601 Rac protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R5F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57776-1", "uniprot_id": "EF1D_MOUSE", "mass": 31293.0, "length": 281, "protein_name": "Elongation factor 1-delta", "gene_name": "Eef1d", "organism": "Mouse", "refseq_name": "elongation factor 1-delta isoform b", "refseq_ac": "NP_001272358", "gene_names_uniprotkb": "Eef1d", "gene_names_refseq": "EF-1-delta; Eef1d", "protein_names_uniprotkb": "Elongation factor 1-delta; EF-1-delta", "protein_names_refseq": "elongation factor 1-delta isoform b; eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)", "tax_id": 10090, "disease": "", "pathway": " (mmu:66656); (R-MMU-156842)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14971650;17242355;17622165;18630941;19131326;19144319;21183079;21750661;23806337;26495903;30084848;35820727;37453647;37507081", "class_list": "", "function": "EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome., [UniProtKB]; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE)., [UniProtKB, UniProtKB]; The up-regulation of expression of TEF-1delta is a novel molecular mechanism responsible, at least in part, for cadmium carcinogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68FG5;Q9CWW2;Q9CWY1;Q9CYD4;Q9CYJ5", "ec_number_list": "", "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0071479 cellular response to ionizing radiation;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P57776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z261-1", "uniprot_id": "CLD7_MOUSE", "mass": 22359.0, "length": 211, "protein_name": "Claudin-7", "gene_name": "Cldn7", "organism": "Mouse", "refseq_name": "claudin-7", "refseq_ac": "NP_001180548", "gene_names_uniprotkb": "Cldn7", "gene_names_refseq": "Cldn7", "protein_names_uniprotkb": "Claudin-7", "protein_names_refseq": "claudin-7", "tax_id": 10090, "disease": "", "pathway": " (mmu:53624)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10601346;14722018;21750661;38654000;9892664", "class_list": "", "function": "Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling. Publication Status: Online-Only, [RefSeq, PubMed]; Claudin-7 was found in the same nephron segments as claudin-8, but it was expressed primarily at the basolateral membrane, [RefSeq, PubMed]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJX4", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0031333 negative regulation of protein-containing complex assembly;GO:2000147 positive regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z261-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05017-1", "uniprot_id": "IGF1_MOUSE", "mass": 17093.0, "length": 153, "protein_name": "Insulin-like growth factor 1", "gene_name": "Igf1", "organism": "Mouse", "refseq_name": "insulin-like growth factor 1 isoform 4 preproprotein", "refseq_ac": "NP_001104745", "gene_names_uniprotkb": "Igf1; Igf-1", "gene_names_refseq": "C730016P09Rik; Igf-1; Igf-I; Igf1", "protein_names_uniprotkb": "Insulin-like growth factor 1; IGF-I; Insulin-like growth factor I; Somatomedin", "protein_names_refseq": "insulin-like growth factor 1 isoform 4 preproprotein; insulin-like growth factor I; somatomedin", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); rheumatic heart disease (Disease Ontology:DOID:0050827); stroke (Disease Ontology:DOID:0051061); pycnodysostosis (Disease Ontology:DOID:0080038); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); PEHO syndrome (Disease Ontology:DOID:0080539); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); microcephaly (Disease Ontology:DOID:10907); IgA vasculitis (Disease Ontology:DOID:11123); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Graves' disease (Disease Ontology:DOID:12361); acoustic neuroma (Disease Ontology:DOID:12689); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); cholestasis (Disease Ontology:DOID:13580); folic acid deficiency anemia (Disease Ontology:DOID:14026); alcoholic neuropathy (Disease Ontology:DOID:14183); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); carotid artery disease (Disease Ontology:DOID:3407); Noonan syndrome (Disease Ontology:DOID:3490); Turner syndrome (Disease Ontology:DOID:3491); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); coronary stenosis (Disease Ontology:DOID:4248); borna disease (Disease Ontology:DOID:5154); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); uveal melanoma (Disease Ontology:DOID:6039); acne (Disease Ontology:DOID:6543); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634); vascular dementia (Disease Ontology:DOID:8725); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); Laron syndrome (Disease Ontology:DOID:9521); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:16000); (R-MMU-114608); (R-MMU-2404192); (R-MMU-2428928); (R-MMU-2428933); (R-MMU-381426); (R-MMU-422085)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "20685873;20881139;21496647;21750661;2474537;3467309;3774549", "class_list": "", "function": "The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (PubMed:21496647). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05018;Q6LDP4;Q8C4U6", "ec_number_list": "", "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0098794 postsynapse", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0014896 muscle hypertrophy;GO:0014904 myotube cell development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05017-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35216-1", "uniprot_id": "CENPA_MOUSE", "mass": 15509.0, "length": 134, "protein_name": "Histone H3-like centromeric protein A", "gene_name": "Cenpa", "organism": "Mouse", "refseq_name": "histone H3-like centromeric protein A isoform 2", "refseq_ac": "NP_001289058", "gene_names_uniprotkb": "Cenpa", "gene_names_refseq": "Cenp-A; Cenpa", "protein_names_uniprotkb": "Histone H3-like centromeric protein A; CENP-A; Centromere protein A", "protein_names_refseq": "centromere autoantigen A; centrosomin A; histone H3-like centromeric protein A isoform 2; histone H3-like centromeric protein A", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336); oligospermia (Disease Ontology:DOID:14228); cancer (Disease Ontology:DOID:162); autoimmune disease (Disease Ontology:DOID:417); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12615); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "12011073;21750661;27499292;28186195;37742188;9465302", "class_list": "", "function": "Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]., [RefSeq]; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:27499292)., [UniProtKB, PubMed, UniProtKB]; Variation in the CENP-A sequence association landscape across diverse inbred mouse strains., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545C9", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0071459 protein localization to chromosome, centromeric region;GO:0000281 mitotic cytokinesis;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35216-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VU6-1", "uniprot_id": "DCA11_MOUSE", "mass": 61992.0, "length": 549, "protein_name": "DDB1- and CUL4-associated factor 11", "gene_name": "Dcaf11", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 11", "refseq_ac": "NP_001185938", "gene_names_uniprotkb": "Dcaf11; D14Ucla1; Wdr23", "gene_names_refseq": "0710008A13Rik; D14Ucla1; Dacf11; Dcaf11; GLO14; Wdr23", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 11; WD repeat-containing protein 23", "protein_names_refseq": "DDB1- and CUL4-associated factor 11; WD repeat domain 23; WD repeat-containing protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:28199); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17242355;21183079;21750661;38242270;38301772", "class_list": "", "function": "Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain., [RefSeq, PubMed]; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB, UniProtKB, UniProtKB]; WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U836;Q8JZV8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0003016 respiratory system process;GO:0006979 response to oxidative stress;GO:0007613 memory;GO:0050890 cognition;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91VU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TV8-1", "uniprot_id": "CLAP1_MOUSE", "mass": 169227.0, "length": 1535, "protein_name": "CLIP-associating protein 1", "gene_name": "Clasp1", "organism": "Mouse", "refseq_name": "CLIP-associating protein 1 isoform 4", "refseq_ac": "NP_001280229", "gene_names_uniprotkb": "Clasp1; Kiaa0622", "gene_names_refseq": "1700030C23Rik; 5730583A19Rik; B130045P17Rik; CLASP1alpha; Clasp1", "protein_names_uniprotkb": "CLIP-associating protein 1; Cytoplasmic linker-associated protein 1", "protein_names_refseq": "CLIP-associating protein 1 isoform 4; cytoplasmic linker-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76707); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-68877); (R-MMU-8854518); (R-MMU-9648025)", "pathway_count": 15, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11290329;15345747;16452087;18854161;21183079;21750661;25428506;30779550;33300544;34418053;34428180;36288343;39627609", "class_list": "", "function": "Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q505G6;Q6DI75;Q6PG14;Q8BNS4;Q99JH5;Q99JI2;Q9CVU1", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0002162 dystroglycan binding;GO:0051010 microtubule plus-end binding;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0030981 cortical microtubule cytoskeleton;GO:0031592 centrosomal corona;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0031111 negative regulation of microtubule polymerization or depolymerization;GO:0051294 establishment of spindle orientation;GO:0051893 regulation of focal adhesion assembly;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80TV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMD2-1", "uniprot_id": "DZIP1_MOUSE", "mass": 97263.0, "length": 852, "protein_name": "Cilium assembly protein DZIP1", "gene_name": "Dzip1", "organism": "Mouse", "refseq_name": "cilium assembly protein DZIP1 isoform 1", "refseq_ac": "NP_080219", "gene_names_uniprotkb": "Dzip1; Kiaa0996", "gene_names_refseq": "2510025K24Rik; 2810422M04Rik; Dzip1", "protein_names_uniprotkb": "Cilium assembly protein DZIP1; DAZ-interacting protein 1 homolog; DAZ-interacting zinc finger protein 1", "protein_names_refseq": "DAZ-interacting protein 1 homolog; DAZ-interacting zinc finger protein 1; cilium assembly protein DZIP1 isoform 1; cilium assembly protein DZIP1; zinc finger protein DZIP1", "tax_id": 10090, "disease": "spermatogenic failure 47 (Disease Ontology:DOID:0112175); coloboma (Disease Ontology:DOID:12270); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:66573); (R-MMU-5632684)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15081113;16368222;21878643;23955340;25428506;25860027;27979967;31118289;32051257;33811421", "class_list": "", "function": "DZIP1 regulates mammalian cardiac valve development through a Cby1-beta-catenin mechanism., [RefSeq, PubMed]; Data indicate that the centrosomal protein DZIP1 interacts with GLI3 transcription factor in the cytoplasm and regulates Hedgehog signaling and ciliogenesis., [RefSeq, PubMed]; Dzip1S mRNA was confined to the spermatogenic lineage, specifically premeiotic spermatogonia, [RefSeq, PubMed]; Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF., [RefSeq, PubMed]; Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:23955340, PubMed:25860027, PubMed:31118289, PubMed:32051257). At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (PubMed:25860027). Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium (PubMed:27979967). It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (PubMed:23955340). Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (PubMed:23955340). It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum (PubMed:32051257). Also indirectly involved in heart development through its function in ciliogenesis (PubMed:31118289)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling., [RefSeq, PubMed]; This gene encodes a zinc finger protein that has been demonstrated to interact with the deleted in azoospermia (DAZ) protein. DAZ plays an important role early in germ cell development to maintain the initial germ cell population. Deletion of this gene in mice compromises Hedgehog signaling during embryogenesis. Mouse embryos lacking the encoded protein show severe developmental defects with dorsalized neural tubes and underdeveloped somites. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 5. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQM0;Q6ZQ10;Q9CRK5", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0140311 protein sequestering activity;GO:0062063 BBSome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0045184 establishment of protein localization;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BMD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAL8-1", "uniprot_id": "DEN5A_MOUSE", "mass": 146653.0, "length": 1287, "protein_name": "DENN domain-containing protein 5A", "gene_name": "Dennd5a", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 5A isoform 2", "refseq_ac": "NP_001298068", "gene_names_uniprotkb": "Dennd5a; Rab6ip1", "gene_names_refseq": "1500012B19Rik; Dennd5a; ORF37; Rab6ip1; mKIAA1091", "protein_names_uniprotkb": "DENN domain-containing protein 5A; Rab6-interacting protein 1; Rab6IP1", "protein_names_refseq": "DENN domain-containing protein 5A isoform 2; DENN domain-containing protein 5A; DENN/MADD domain containing 5A; Rab6 interacting protein 1; rab6-interacting protein 1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 49 (Disease Ontology:DOID:0080441)", "pathway": " (mmu:19347); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17725553;19141279;21183079;21543860;21750661;22558185;30084848;34428180;7782346", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days, [RefSeq, PubMed]; May couple Rab6 and Rab11 function throughout the cell cycle; R6IP1 overexpression alters the distribution of peripheral recycling endosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62146;Q8C829;Q8VDF6;Q9QYZ2", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0030904 retromer complex", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6PAL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DMN7-1", "uniprot_id": "DCAM1_MOUSE", "mass": 38272.0, "length": 334, "protein_name": "S-adenosylmethionine decarboxylase proenzyme 1", "gene_name": "Amd1", "organism": "Mouse", "refseq_name": "S-adenosylmethionine decarboxylase proenzyme 1", "refseq_ac": "NP_033795", "gene_names_uniprotkb": "Amd1", "gene_names_refseq": "AdoMetDC; Amd-1; Amd1; SAMDC 1; SAMDC; adoMetDC1", "protein_names_uniprotkb": "S-adenosylmethionine decarboxylase proenzyme 1; 4.1.1.50; AdoMetDC 1; SAMDC 1", "protein_names_refseq": "S-adenosylmethionine decarboxylase proenzyme 1; adoMetDC 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:11702); (R-MMU-351202)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10570962;11856372;1449493;21750661;22391449;31219806;33203990;33783988;8344293", "class_list": "", "function": "AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth., [RefSeq, PubMed]; AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation., [RefSeq, PubMed]; Amd1 is a major regulator of embryonic stem cell self-renewal and that its essential role lies in its regulation of Myc levels within the cell, [RefSeq, PubMed]; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P31154;P82184;Q58E47", "ec_number_list": "4.1.1.50", "go_molecular_function": "GO:0019810 putrescine binding;GO:0042802 identical protein binding;GO:0004014 adenosylmethionine decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process;GO:0046500 S-adenosylmethionine metabolic process;GO:0006595 polyamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0DMN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K382-1", "uniprot_id": "DEN1A_MOUSE", "mass": 111538.0, "length": 1016, "protein_name": "DENN domain-containing protein 1A", "gene_name": "Dennd1a", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 1A isoform 2", "refseq_ac": "NP_666234", "gene_names_uniprotkb": "Dennd1a", "gene_names_refseq": "6030446I19Rik; Dennd1a; connecdenn", "protein_names_uniprotkb": "DENN domain-containing protein 1A; Connecdenn 1; Connecdenn", "protein_names_refseq": "DENN domain-containing protein 1A isoform 2; DENN domain-containing protein 1A; DENN/MADD domain containing 1A; connecdenn 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227801); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17182770;19144319;20159556;21183079;21750661;24129315;30884041;31599954;32848054;35820727;40885482", "class_list": "", "function": "Connecdenn is a component of the endocytic machinery functioning in synaptic vesicle endocytosis, providing the first evidence of a role for a DENN domain-containing protein in endocytosis., [RefSeq, PubMed]; Dennd1a is essential for embryogenesis, probably through the mediation of endocytic recycling of selective cargos that are involved in cell signaling crucial for the development of multiple embryonic organ systems., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:17182770, PubMed:20159556). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (PubMed:20159556)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A0MCI0;A2ALU2", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0006897 endocytosis;GO:0015031 protein transport;GO:0043547 positive regulation of GTPase activity;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K382-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4S8-1", "uniprot_id": "DEN2A_MOUSE", "mass": 113094.0, "length": 1000, "protein_name": "DENN domain-containing protein 2A", "gene_name": "Dennd2a", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 2A isoform a", "refseq_ac": "NP_766065", "gene_names_uniprotkb": "Dennd2a", "gene_names_refseq": "B930096L08Rik; C130031G22; Dennd2a; mKIAA1277", "protein_names_uniprotkb": "DENN domain-containing protein 2A", "protein_names_refseq": "DENN domain-containing protein 2A isoform a; DENN domain-containing protein 2A; DENN/MADD domain containing 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:209773); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJU2;Q3TUG3;Q3UXA3", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C4S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88809-1", "uniprot_id": "DCX_MOUSE", "mass": 40613.0, "length": 366, "protein_name": "Neuronal migration protein doublecortin", "gene_name": "Dcx", "organism": "Mouse", "refseq_name": "neuronal migration protein doublecortin isoform a", "refseq_ac": "NP_001103692", "gene_names_uniprotkb": "Dcx; Dcn", "gene_names_refseq": "Dbct; Dcx", "protein_names_uniprotkb": "Neuronal migration protein doublecortin; Doublin; Lis-X; Lissencephalin-X", "protein_names_refseq": "doublecortex; doublin; lis-X; lissencephalin-X; lissencephaly, X-linked (doublecortin); neuronal migration protein doublecortin isoform a; neuronal migration protein doublecortin", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); subcortical band heterotopia (Disease Ontology:DOID:0111169); X-linked lissencephaly 1 (Disease Ontology:DOID:0112239); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain infarction (Disease Ontology:DOID:3454); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:13193)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15099191;15345747;20715151;21183079;22807455;25088421;31219806;9668176;9837748", "class_list": "", "function": "Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration., [UniProtKB, UniProtKB]; This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6E5A4", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0001764 neuron migration;GO:0021766 hippocampus development;GO:0007420 brain development;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88809-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1T9-1", "uniprot_id": "DEN1B_MOUSE", "mass": 85526.0, "length": 766, "protein_name": "DENN domain-containing protein 1B", "gene_name": "Dennd1b", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 1B isoform 1", "refseq_ac": "NP_001159973", "gene_names_uniprotkb": "Dennd1b", "gene_names_refseq": "4632404N19Rik; 4930467M19Rik; 6820401H01Rik; Dennd1b; F730008N07Rik", "protein_names_uniprotkb": "DENN domain-containing protein 1B; Connecdenn 2", "protein_names_refseq": "ASL1/9AS1-1 fusion; DENN domain-containing protein 1B isoform 1; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; connecdenn 2", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); asthma (Disease Ontology:DOID:2841); intrinsic asthma (Disease Ontology:DOID:9360); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:329260); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21750661;25428506;26774822;33135087", "class_list": "", "function": "A novel DENND1B-localized structure found at the basal side of adherent cells., [RefSeq, PubMed]; Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RUR7;E9Q246;Q8CG96;Q9D5B9", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0043547 positive regulation of GTPase activity;GO:0050852 T cell receptor signaling pathway;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U1T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T85-1", "uniprot_id": "DCAF5_MOUSE", "mass": 103676.0, "length": 946, "protein_name": "DDB1- and CUL4-associated factor 5", "gene_name": "Dcaf5", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 5 isoform 1", "refseq_ac": "NP_796241", "gene_names_uniprotkb": "Dcaf5; Kiaa1824; Wdr22", "gene_names_refseq": "9430020B07Rik; BCRG2; BCRP2; Dcaf5; Wdr22", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 5; WD repeat-containing protein 22", "protein_names_refseq": "DDB1- and CUL4-associated factor 5 isoform 1; WD repeat domain 22; WD repeat-containing protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:320808); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;29691401;30442713;34428180", "class_list": "", "function": "Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4), involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2 (PubMed:30442713). The complex CRL4-DCAF5 is also involved in the ubiquitination of methylated DNMT1 and E2F1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Knockdown of L3MBTL3 or DCAF5 is sufficient to restore the protein levels of SOX2 and rescue the defects of mouse embryonic stem cells caused by LSD1 or PHF20L1 deficiency., [RefSeq, PubMed]; L3MBTL3 binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80VT3;Q80ZW6;Q8BIP8;Q8BVK5;Q8K0Q6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0016567 protein ubiquitination;GO:0030163 protein catabolic process;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80T85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8N7N5-1", "uniprot_id": "DCAF8_MOUSE", "mass": 66031.0, "length": 591, "protein_name": "DDB1- and CUL4-associated factor 8", "gene_name": "Dcaf8", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 8 isoform 1", "refseq_ac": "NP_705783", "gene_names_uniprotkb": "Dcaf8; D1Ucla4; H326; Wdr42a", "gene_names_refseq": "D1Dau35e; D1Ucla4; Dcaf8; H326; Wdr42a", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 8; WD repeat-containing protein 42A", "protein_names_refseq": "DDB1- and CUL4-associated factor 8 isoform 1; WD repeat domain 42A; WD repeat-containing protein 42A", "tax_id": 10090, "disease": "giant axonal neuropathy 2 (Disease Ontology:DOID:0090069)", "pathway": " (mmu:98193); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11401431;17208939;21183079;21750661;33855678;34428180", "class_list": "", "function": "DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis., [RefSeq, PubMed]; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CII7;Q8CIK6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0014904 myotube cell development;GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8N7N5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIC3-1", "uniprot_id": "DCR1A_MOUSE", "mass": 113567.0, "length": 1026, "protein_name": "DNA cross-link repair 1A protein", "gene_name": "Dclre1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dclre1a; Kiaa0086; Snm1a; Snm1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA cross-link repair 1A protein; 3.5.2.6; Beta-lactamase MBLAC2; SNM1 homolog A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:55947); (R-MMU-6783310)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10848582;15542852;21183079;21750661;31219806;35820727", "class_list": "", "function": "May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q571H5;Q6GQR6", "ec_number_list": "3.4.13.19;3.5.2.6;3.1.21.-;3.1.4.1;3.6.4.13;3.4.19.12;3.1.2.2;3.1.-.-;3.1.22.-;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008800 beta-lactamase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0051301 cell division;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JIC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXT1-1", "uniprot_id": "DAPP1_MOUSE", "mass": 32167.0, "length": 280, "protein_name": "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide", "gene_name": "Dapp1", "organism": "Mouse", "refseq_name": "dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1", "refseq_ac": "NP_036062", "gene_names_uniprotkb": "Dapp1; Bam32", "gene_names_refseq": "Bam32; Dapp1", "protein_names_uniprotkb": "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa; mDAPP1", "protein_names_refseq": "B-cell adapter molecule of 32 kDa; b lymphocyte adapter protein Bam32; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide", "tax_id": 10090, "disease": "", "pathway": " (mmu:26377); (R-MMU-983695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10432293;10770799;15989784;17947660;19144319;25605945;25875604;31219806;31869344;32536926;33673180;34428180", "class_list": "", "function": "Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species in WKYMVm-Induced Microvascular Hyperpermeability. Publication Status: Online-Only, [RefSeq, PubMed]; May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K., [UniProtKB]; Results functionally demonstrated that Dapp1 modulates lung resistance in response to diesel exhaust particles exposure, thus providing evidence for a novel gene-environment interaction that influences asthma-related traits in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment. Publication Status: Online-Only, [RefSeq, PubMed]; The interaction of Bam32 with Lyn leads to Bam32 phosphorylation, which might play an important role in activating downstream signaling molecules., [RefSeq, PubMed]; These data show that Bam32 is important for optimal anti-trypanosome IgG antibody response and suppression of disease-promoting proinflammatory cytokines. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R178", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QXT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYB2-1", "uniprot_id": "DACH1_MOUSE", "mass": 77972.0, "length": 751, "protein_name": "Dachshund homolog 1", "gene_name": "Dach1", "organism": "Mouse", "refseq_name": "dachshund homolog 1 isoform 2", "refseq_ac": "NP_001033699", "gene_names_uniprotkb": "Dach1; Dach", "gene_names_refseq": "Dach1; Dach; Dac", "protein_names_uniprotkb": "Dachshund homolog 1; Dach1", "protein_names_refseq": "dachshund 1; dachshund homolog 1 isoform 2; dachshund homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13134)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10502109;10502110;11543628;12130660;12215533;14628042;21183079;30084848;9651501;9915577", "class_list": "", "function": "The mouse dachshund gene is related to the Ski proto-oncogene and is expressed in eye and limb., [RefSeq, PubMed]; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RUG1;O88716;Q8BPQ0;Q8C8D7;Q9QY47;Q9R218;Q9Z0Y5", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001967 suckling behavior;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QYB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQF5-1", "uniprot_id": "DPYS_MOUSE", "mass": 56725.0, "length": 519, "protein_name": "Dihydropyrimidinase", "gene_name": "Dpys", "organism": "Mouse", "refseq_name": "dihydropyrimidinase", "refseq_ac": "NP_001157938", "gene_names_uniprotkb": "Dpys", "gene_names_refseq": "1200017I10Rik; 1300004I01Rik; DHPase; DHP; Dpys", "protein_names_uniprotkb": "Dihydropyrimidinase; 3.5.2.2; DHPase; DHP; Dihydropyrimidine amidohydrolase; Hydantoinase", "protein_names_refseq": "dihydropyrimidinase; dihydropyrimidine amidohydrolase; hydantoinase", "tax_id": 10090, "disease": "dihydropyrimidinase deficiency (Disease Ontology:DOID:0111629); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (mmu:64705); (R-MMU-73621)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10956643;21750661;23806337;31616917;34428180;37453647", "class_list": "", "function": "Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99PP1;Q9DBK3;Q9DBP7", "ec_number_list": "3.5.2.2", "go_molecular_function": "GO:0002058 uracil binding;GO:0002059 thymine binding;GO:0004157 dihydropyrimidinase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006208 pyrimidine nucleobase catabolic process;GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process;GO:0019860 uracil metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EQF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35393-1", "uniprot_id": "EFNB3_MOUSE", "mass": 35885.0, "length": 340, "protein_name": "Ephrin-B3", "gene_name": "Efnb3", "organism": "Mouse", "refseq_name": "ephrin-B3 precursor", "refseq_ac": "NP_031937", "gene_names_uniprotkb": "Efnb3", "gene_names_refseq": "EFL-6; ELF-3; Efnb3; Elk-L3; Epl8; LERK-8; NLERK-2", "protein_names_uniprotkb": "Ephrin-B3", "protein_names_refseq": "ephrin-B3 precursor", "tax_id": 10090, "disease": "movement disease (Disease Ontology:DOID:480)", "pathway": " (mmu:13643); (R-MMU-2682334); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10704386;19349973;24129315;27446912;30789343;38142837;9484836", "class_list": "", "function": "Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons., [UniProtKB, PubMed]; Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0098839 postsynaptic density membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse", "go_biological_process": "GO:0016198 axon choice point recognition;GO:0048013 ephrin receptor signaling pathway;GO:0031295 T cell costimulation;GO:0007628 adult walking behavior;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35393-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33609-1", "uniprot_id": "DPOLA_MOUSE", "mass": 167340.0, "length": 1465, "protein_name": "DNA polymerase alpha catalytic subunit", "gene_name": "Pola1", "organism": "Mouse", "refseq_name": "DNA polymerase alpha catalytic subunit", "refseq_ac": "NP_032918", "gene_names_uniprotkb": "Pola1; Pola", "gene_names_refseq": "Pola1; Pola", "protein_names_uniprotkb": "DNA polymerase alpha catalytic subunit; 2.7.7.7; DNA polymerase alpha catalytic subunit p180", "protein_names_refseq": "DNA polymerase alpha 1, 180 kDa; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha catalytic subunit; G7a/Bat6Hom; polymerase, alpha 1", "tax_id": 10090, "disease": "X-linked reticulate pigmentary disorder (Disease Ontology:DOID:0111834); Van Esch-O'Driscoll syndrome (Disease Ontology:DOID:0111840)", "pathway": " (mmu:18968); (R-MMU-113501); (R-MMU-174411); (R-MMU-174430); (R-MMU-68952); (R-MMU-68962); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "21183079;23806337;28528544;31006512;33711210;34428180;39627609;8026492;8125989;8253737;8463324", "class_list": "", "function": "Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:8026492, PubMed:8253737). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses., [UniProtKB, UniProtKB, PubMed, PubMed]; The intrinsically disordered N-terminal region of mouse DNA polymerase alpha mediates its interaction with POT1a/b at telomeres., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.49;3.1.11.-;2.7.7.31;3.1.21.-;2.7.7.102;3.6.4.12;2.7.7.7;3.1.-.-;4.2.99.-;2.7.11.22;5.6.2.-;4.2.99.18;5.6.2.4;2.7.11.1", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003887 DNA-directed DNA polymerase activity;GO:0019103 pyrimidine nucleotide binding;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006272 leading strand elongation;GO:0006273 lagging strand elongation;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P33609-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61010-1", "uniprot_id": "DTX1_MOUSE", "mass": 68119.0, "length": 627, "protein_name": "E3 ubiquitin-protein ligase DTX1", "gene_name": "Dtx1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase DTX1 isoform b", "refseq_ac": "NP_032078", "gene_names_uniprotkb": "Dtx1", "gene_names_refseq": "Dtx1; Fxit1; mKIAA4160", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DTX1; 2.3.2.27; Deltex1; FXI-T1; Protein deltex-1; RING-type E3 ubiquitin transferase DTX1; mDTX1", "protein_names_refseq": "E3 ubiquitin-protein ligase DTX1 isoform b; E3 ubiquitin-protein ligase DTX1; FXI-T1; RING-type E3 ubiquitin transferase DTX1; deltex 1 homolog; deltex1; fractionated x-irradiation induced transcript 1; mDTX1; protein deltex-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14357); (R-MMU-2122948)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11226752;11731257;15684388;25695215;32736174;36374959;8853908", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination and proteasomal degradation of MEKK1, thereby modulating signaling pathways involved in cell fate determination (PubMed:15684388). Regulates the Notch signaling pathway, acting predominantly as a positive regulator but functioning as a context-dependent negative regulator in specific developmental or cellular settings. Mediates the antineural activity of Notch signaling, likely by inhibiting transcriptional activation mediated by MATCH1. Negatively regulates Notch signaling by controlling the activity of PIP4K2C, a lipid kinase that promotes recycling of Notch receptors from RAB4A-positive endosomes to the cell surface. Participates in several developmental and immune processes, including neurogenesis, lymphogenesis, and myogenesis. Influences lymphocyte differentiation by promoting B-cell development at the expense of T-cell development, suggesting functional antagonism of NOTCH1 in this context. Also promotes degradation of PRKCQ via the endosome-lysosome pathway, contributing to PKCtheta downregulation during T-cell anergy. In addition, facilitates differentiation of Th17 cells by inducing expression and DNA-binding activity of RORgT (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 protein Publication Status: Online-Only, [RefSeq, PubMed]; MiR-210-3p Impairs Pancreatic beta-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TER5;Q8C2H2;Q9ER09", "ec_number_list": "3.4.23.-;2.3.2.27;2.3.2.26", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0031625 ubiquitin protein ligase binding;GO:0005112 Notch binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0045665 negative regulation of neuron differentiation;GO:1990830 cellular response to leukemia inhibitory factor;GO:0016567 protein ubiquitination;GO:0010001 glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGS6-1", "uniprot_id": "DPOLQ_MOUSE", "mass": 280714.0, "length": 2544, "protein_name": "DNA polymerase theta", "gene_name": "Polq", "organism": "Mouse", "refseq_name": "DNA polymerase theta isoform 2", "refseq_ac": "NP_001152841", "gene_names_uniprotkb": "Polq; Chaos1", "gene_names_refseq": "A430110D14Rik; Polq", "protein_names_uniprotkb": "DNA polymerase theta; 2.7.7.49; Chromosome aberrations occurring spontaneously protein 1; DNA polymerase eta; RNA-directed DNA polymerase POLQ", "protein_names_refseq": "DNA polymerase eta; DNA polymerase theta isoform 2; DNA polymerase theta; chromosome aberrations occurring spontaneously protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77782); (R-MMU-5685939)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "12663541;14735462;15542845;16172387;16222339;16890500;17449470;18485835;19630521;21883722;25275444;25642960;25642963;28687761;29058711;29079701;30773314;31537809;34428180", "class_list": "", "function": "DNA Pol theta has a specialized function in lymphocytes and in tumor progression, [RefSeq, PubMed]; Low-fidelity DNA polymerase with a putative helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:21883722, PubMed:25275444, PubMed:25642960, PubMed:25642963, PubMed:29079701, PubMed:31537809). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25275444, PubMed:25642960, PubMed:25642963, PubMed:29079701, PubMed:31537809). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (By similarity). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (PubMed:30773314). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (By similarity). It then extends each strand from the base-paired region using the opposing overhang as a template (By similarity). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (By similarity). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (By similarity). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (By similarity). Promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:29058711). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642960, PubMed:25642963, PubMed:29058711). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (By similarity). May also have lyase activity (By similarity). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (PubMed:16172387, PubMed:16222339, PubMed:16890500, PubMed:17449470). However, POLQ does not play a major role in somatic hypermutation (PubMed:18485835). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28687761)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Polq has a role in maintaining genomic integrity, which is probably distinctive from the major homologous recombination pathway regulated by ATM, [RefSeq, PubMed]; Polq-inactive mice exhibited a reduced level of serum IgM and IgG1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTE0", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;2.7.7.49;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.1.11.-;2.7.7.31;3.1.21.-;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;2.7.7.7;3.6.4.6;4.2.99.-;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;2.7.7.102;3.4.21.53;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0051260 protein homooligomerization;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8CGS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE01-1", "uniprot_id": "DUS18_MOUSE", "mass": 21119.0, "length": 188, "protein_name": "Dual specificity protein phosphatase 18", "gene_name": "Dusp18", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 18", "refseq_ac": "NP_776106", "gene_names_uniprotkb": "Dusp18", "gene_names_refseq": "4930527G07Rik; DSP18; DUSP20; Dusp18; LMWDSP20", "protein_names_uniprotkb": "Dual specificity protein phosphatase 18; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 18; low molecular weight dual specificity phosphatase 20", "tax_id": 10090, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404)", "pathway": " (mmu:75219)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18385140;31219806;38346942;38992029", "class_list": "", "function": "Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). In bone tissue, upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, DUSP18 is recruited to the KISS1R C-terminus, where it dephosphorylates SRC resulting in down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (PubMed:38346942)., [UniProtKB, UniProtKB, PubMed]; Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane, [RefSeq, PubMed]; Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0006612 protein targeting to membrane;GO:0006626 protein targeting to mitochondrion;GO:0046677 response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VE01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBM2-1", "uniprot_id": "ECHP_MOUSE", "mass": 78301.0, "length": 718, "protein_name": "Peroxisomal bifunctional enzyme", "gene_name": "Ehhadh", "organism": "Mouse", "refseq_name": "peroxisomal bifunctional enzyme", "refseq_ac": "NP_076226", "gene_names_uniprotkb": "Ehhadh; L-pbe", "gene_names_refseq": "1300002P22Rik; Ehhadh; HD; L-PBE; LBFP; LBP; MFE1; MFP-1; MFP1; MFP; PBFE", "protein_names_uniprotkb": "Peroxisomal bifunctional enzyme; L-PBE; L-peroxisomal bifunctional enzyme; MFE1; MFP-1; Multifunctional enzyme 1; Multifunctional protein 1; PBE; PBFE", "protein_names_refseq": "L-bifunctional enzyme; L-peroxisomal bifunctional enzyme; L-specific multifunctional beta-oxdiation protein; PBE; multifunctional enzyme 1; multifunctional protein 1; peroxisomal bifunctional enzyme", "tax_id": 10090, "disease": "Fanconi renotubular syndrome 3 (Disease Ontology:DOID:0080759)", "pathway": " (mmu:74147); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "17442273;21183079;23576753;23806337;24075987;34110423;34428180;36064721;37453647", "class_list": "", "function": "Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis., [RefSeq, PubMed]; Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (PubMed:17442273, PubMed:24075987). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (Probable). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (PubMed:24075987). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W49", "ec_number_list": "1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.3.3.8;4.2.1.17;2.3.1.-;1.1.1.211", "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0019899 enzyme binding;GO:0070403 NAD+ binding;GO:0004300 enoyl-CoA hydratase activity;GO:0018812 3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006637 acyl-CoA metabolic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DBM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5MJS3-1", "uniprot_id": "FA20C_MOUSE", "mass": 65766.0, "length": 579, "protein_name": "Extracellular serine/threonine protein kinase FAM20C", "gene_name": "Fam20c", "organism": "Mouse", "refseq_name": "extracellular serine/threonine protein kinase FAM20C isoform 1", "refseq_ac": "NP_085042", "gene_names_uniprotkb": "Fam20c; Dmp4; Kiaa4081", "gene_names_refseq": "DMP-4; DMP4; Fam20c; GEF-CK; mKIAA4081", "protein_names_uniprotkb": "Extracellular serine/threonine protein kinase FAM20C; 2.7.11.1; DMP-4; Dentin matrix protein 4; GEF-CK; Golgi-enriched fraction casein kinase", "protein_names_refseq": "dentin matrix protein 4; extracellular serine/threonine protein kinase FAM20C isoform 1; extracellular serine/threonine protein kinase Fam20C; family with sequence similarity 20, member C; golgi-enriched fraction casein kinase", "tax_id": 10090, "disease": "X-linked hypophosphatemic rickets (Disease Ontology:DOID:0050445); rickets (Disease Ontology:DOID:10609); amelogenesis imperfecta (Disease Ontology:DOID:2187)", "pathway": " (mmu:80752); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17369251;17924334;20644212;21549343;21750661;22732358;22900076;25789606;30084848;34428180;36914045;37357253;37698039;38552750", "class_list": "", "function": "Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation., [RefSeq, PubMed]; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22732358, PubMed:22900076, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (By similarity). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (By similarity). This is critical to maintain ER proteostasis and reduce cell death under ER stress (By similarity). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (By similarity). Required for osteoblast differentiation and mineralization (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome., [RefSeq, PubMed]; Knocking out FAM20C in pre-osteoblasts leads to up-regulation of osteoclast differentiation to affect long bone development., [RefSeq, PubMed]; Mutations of family with sequence similarity 20-member C gene causing lethal and nonlethal Raine syndrome causes hypophosphatemia rickets., [RefSeq, PubMed]; Temporospatial expression profile of FAM20C, [RefSeq, PubMed]; This study defines the causative role of FAM20C in this lethal osteosclerotic disorder and its crucial role in normal bone development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJP0;Q571A3;Q6PKA8;Q8JZP7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;3.4.24.81;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;3.6.4.-;2.7.11.17;5.3.4.1;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;3.4.21.69;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;2.3.1.48;3.4.21.-;2.4.1.145;4.1.1.32;3.1.1.4;3.1.1.3;1.8.3.2;2.7.11.38;3.1.1.98;3.6.1.-;3.2.1.51;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;3.4.21.112;2.7.1.150", "go_molecular_function": "GO:0002020 protease binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0036179 osteoclast maturation;GO:0051174 regulation of phosphorus metabolic process;GO:0097187 dentinogenesis;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q5MJS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35250-1", "uniprot_id": "EXOC7_MOUSE", "mass": 79960.0, "length": 697, "protein_name": "Exocyst complex component 7", "gene_name": "Exoc7", "organism": "Mouse", "refseq_name": "exocyst complex component 7 isoform 2", "refseq_ac": "NP_001156344", "gene_names_uniprotkb": "Exoc7; Exo70", "gene_names_refseq": "Exo70; Exoc7; sec70", "protein_names_uniprotkb": "Exocyst complex component 7; Exocyst complex component Exo70", "protein_names_refseq": "exocyst complex component 7 isoform 2; exocyst complex component Exo70; exocyst component protein 70 kDa homolog", "tax_id": 10090, "disease": "microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:53413); (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12687004;16601687;17583731;21750661;30779550;31197029;31740584;34428180;38325858", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion. It is required for neuron survival and plays an essential role in cortical development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice., [RefSeq, PubMed]; Exo70 mediates AMPA receptor insertion at the postsynaptic membrane, but it does not participate in receptor targeting., [RefSeq, PubMed]; Given the low level of sequence conservation within Exo70, this structure provides new insights into our understanding of many species-specific functions of the exocyst, [RefSeq, PubMed]; Here we show that microtubule stabilization, triggered by engagement of the B cell receptor, acts as a cue to release centrosome-associated Exo70, which is redistributed to the immune synapse. This process is coupled to the recruitment and activation of GEF-H1, which is required for assembly of the exocyst complex, used to promote tethering and fusion of lysosomes at the immune synapse., [RefSeq, PubMed]; Insulin-stimulated GLUT4 exocytosis was markedly inhibited in Exoc7 KO adipocytes., [RefSeq, PubMed]; The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K121", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0005815 microtubule organizing center", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0051963 regulation of synapse assembly;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35250-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20934-1", "uniprot_id": "EVI2A_MOUSE", "mass": 24087.0, "length": 223, "protein_name": "Protein EVI2A", "gene_name": "Evi2a", "organism": "Mouse", "refseq_name": "protein EVI2A precursor", "refseq_ac": "NP_001028883", "gene_names_uniprotkb": "Evi2a; Evi-2a; Evi-2; Evi2", "gene_names_refseq": "Evi-2; Evi2a; Evi2", "protein_names_uniprotkb": "Protein EVI2A; EVI-2A; Ecotropic viral integration site 2A protein", "protein_names_refseq": "EVI-2A; ecotropic viral integration site 2A protein; protein EVI2A precursor; protein EVI2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:14017)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11465105;19144319;2167436;21750661;26495903;27802388;28011936;29187734;30899004;34428180;35984892", "class_list": "", "function": "May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6DKP1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0035869 ciliary transition zone", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P20934-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70429-1", "uniprot_id": "EVL_MOUSE", "mass": 44337.0, "length": 414, "protein_name": "Ena/VASP-like protein", "gene_name": "Evl", "organism": "Mouse", "refseq_name": "ena/VASP-like protein isoform 1", "refseq_ac": "NP_001156866", "gene_names_uniprotkb": "Evl", "gene_names_refseq": "Evl; b2b2600Clo", "protein_names_uniprotkb": "Ena/VASP-like protein; Ena/vasodilator-stimulated phosphoprotein-like", "protein_names_refseq": "ena/VASP-like protein isoform 1; ena/VASP-like protein", "tax_id": 10090, "disease": "tauopathy (Disease Ontology:DOID:680)", "pathway": " (mmu:14026); (R-MMU-376176); (R-MMU-5663220)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10069337;10087267;10404224;10945997;10993894;14506234;19144319;21183079;21750661;25428506;26495903;29187734;33512764;8861907", "class_list": "", "function": "EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis., [RefSeq, PubMed]; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERU8", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030027 lamellipodium;GO:0001725 stress fiber", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:1900028 negative regulation of ruffle assembly;GO:0051289 protein homotetramerization;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P70429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61545-1", "uniprot_id": "EWS_MOUSE", "mass": 68462.0, "length": 655, "protein_name": "RNA-binding protein EWS", "gene_name": "Ewsr1", "organism": "Mouse", "refseq_name": "RNA-binding protein EWS isoform 2", "refseq_ac": "NP_031994", "gene_names_uniprotkb": "Ewsr1; Ewsh; Ews", "gene_names_refseq": "Ewsh; Ewsr1; Ews", "protein_names_uniprotkb": "RNA-binding protein EWS", "protein_names_refseq": "Ewing sarcoma homolog; RNA-binding protein EWS isoform 2; RNA-binding protein EWS", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 6 (Disease Ontology:DOID:0060198); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Ewing sarcoma (Disease Ontology:DOID:3369); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:14030)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "12509448;18250455;19224205;20173027;21750661;23386199;23806337;24129315;24928395;27605304;27932493;31219806;33300544;34418053;34428180;34887587;35921433;35984892;37507081;37709831;39627609;40997131;7829090", "class_list": "", "function": "Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). Might function as a transcriptional repressor (By similarity)., [UniProtKB, UniProtKB]; EWS has a role in mesodermal cell differentiation, [RefSeq, PubMed]; Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses., [RefSeq, PubMed]; In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2P0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q61545-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VP1-1", "uniprot_id": "EPN1_MOUSE", "mass": 60212.0, "length": 575, "protein_name": "Epsin-1", "gene_name": "Epn1", "organism": "Mouse", "refseq_name": "epsin-1 isoform 1", "refseq_ac": "NP_001239383", "gene_names_uniprotkb": "Epn1", "gene_names_refseq": "Epn1; Ibp1", "protein_names_uniprotkb": "Epsin-1; EPS-15-interacting protein 1; Ibp1; Intersectin-EH-binding protein 1", "protein_names_refseq": "EPS-15-interacting protein 1; epsin-1 isoform 1; intersectin-EH-binding protein 1", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:13854); (R-MMU-182971); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "15345747;16574660;17242355;19144319;19666558;21183079;21750661;22517741;22645316;23187125;24129315;25428506;27802388;30779550;31219806;32770009;32848054;32960814;34440686;35820727;40021952;40885482;9813051;9920862", "class_list": "", "function": "Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Epsin has a role as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling in mammals, [RefSeq, PubMed]; Epsin is an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface, [RefSeq, PubMed]; Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development., [RefSeq, PubMed]; Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of epsins 1 and 2 impaired endocytosis and degradation of VEGFR2, resulting in excessive VEGF signaling and compromised tumor vascular function., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "O70446;Q6NX78", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0044325 transmembrane transporter binding;GO:0030276 clathrin binding;GO:0035615 clathrin adaptor activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1905445 positive regulation of clathrin coat assembly;GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0007219 Notch signaling pathway;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q80VP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHU3-1", "uniprot_id": "EPN2_MOUSE", "mass": 63472.0, "length": 595, "protein_name": "Epsin-2", "gene_name": "Epn2", "organism": "Mouse", "refseq_name": "epsin-2 isoform 3", "refseq_ac": "NP_001239118", "gene_names_uniprotkb": "Epn2", "gene_names_refseq": "9530051D10Rik; Epn2; Ibp2", "protein_names_uniprotkb": "Epsin-2; EPS-15-interacting protein 2; Ibp2; Intersectin-EH-binding protein 2", "protein_names_refseq": "EPS-15-interacting protein 2; epsin-2 isoform 3; intersectin-EH-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13855); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "15345747;21183079;21750661;22872234;24129315;25428506;30059200;30084848;31219806;34428180;34440686;34678516;35822049;36852467;40021952;40885482;9813051", "class_list": "", "function": "Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the formation of clathrin-coated invaginations and endocytosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O70447;Q5NCM4;Q8BZ85", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030128 clathrin coat of endocytic vesicle;GO:0098843 postsynaptic endocytic zone", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0007219 Notch signaling pathway;GO:0030100 regulation of endocytosis;GO:0045747 positive regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8CHU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0F8-1", "uniprot_id": "FAHD1_MOUSE", "mass": 24521.0, "length": 221, "protein_name": "Oxaloacetate tautomerase FAHD1, mitochondrial", "gene_name": "Fahd1", "organism": "Mouse", "refseq_name": "oxaloacetate tautomerase FAHD1, mitochondrial", "refseq_ac": "NP_075969", "gene_names_uniprotkb": "Fahd1; MNCb-4134", "gene_names_refseq": "1110025H10Rik; ApH; Fahd1; ODx", "protein_names_uniprotkb": "Oxaloacetate tautomerase FAHD1, mitochondrial; 3.7.1.5; 4.1.1.112; 5.3.2.2; Acylpyruvase FAHD1; Acylpyruvate hydrolase; ApH; Fumarylacetoacetate hydrolase domain-containing protein 1; OAA decarboxylase; ODx; Oxaloacetate decarboxylase", "protein_names_refseq": "OAA decarboxylase; acylpyruvase FAHD1, mitochondrial; acylpyruvate hydrolase; fumarylacetoacetate hydrolase domain-containing protein 1; oxaloacetate decarboxylase, mitochondrial; oxaloacetate decarboxylase; oxaloacetate tautomerase FAHD1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68636); (R-MMU-70268)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;21878618;23576753;23806337;25575590;32068790;34440809;37507081", "class_list": "", "function": "Based on molecular modeling and subsequent biochemical investigations, the study identified FAHD1 as a eukaryotic oxaloacetate decarboxylase enzyme., [RefSeq, PubMed]; High Glycolytic Activity Enhances Stem Cell Reprogramming of Fahd1-KO Mouse Embryonic Fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Identified mammalian FAHD1 as a novel mitochondrial enzyme with acylpyruvate hydrolase activity., [RefSeq, PubMed]; Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse., [RefSeq, PubMed]; Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (By similarity). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (By similarity). Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle (Probable) (PubMed:25575590, PubMed:32068790). Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (PubMed:32068790)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U020;Q3UQY4;Q8BLJ7;Q9JJB2", "ec_number_list": "1.1.1.40;5.3.2.2;3.7.1.5;4.1.1.112;1.1.1.38", "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0018773 acetylpyruvate hydrolase activity;GO:0034545 fumarylpyruvate hydrolase activity;GO:0047621 acylpyruvate hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R0F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R123-1", "uniprot_id": "FAD1_MOUSE", "mass": 54766.0, "length": 492, "protein_name": "Bifunctional FAD diphosphatase/FAD synthase", "gene_name": "Flad1", "organism": "Mouse", "refseq_name": "bifunctional FAD diphosphatase/FAD synthase", "refseq_ac": "NP_796015", "gene_names_uniprotkb": "Flad1", "gene_names_refseq": "A930017E24Rik; Flad1; Pp591", "protein_names_uniprotkb": "Bifunctional FAD diphosphatase/FAD synthase; FAD pyrophosphatase; FADHy; FADPPase; FMN adenylyltransferase; FMNAT; Flavin adenine dinucleotide synthase; NADH diphosphatase", "protein_names_refseq": "FAD pyrophosphorylase; FAD synthase; FAD synthetase; FMN adenylyltransferase; RFad1, flavin adenine dinucleotide synthetase, homolog; bifunctional FAD diphosphatase/FAD synthase; flavin adenine dinucleotide synthase", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:319945); (R-MMU-196843)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21750661;23576753;23806337;31219806", "class_list": "", "function": "This enzyme has two activities: FAD diphosphatase activity and FAD synthase activity. FAD diphosphatase acts on FAD and NADH to produce FMN and NMNH(2-), respectively. FAD synthase catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In addition to its catalytic activities, the protein also facilitates the delivery of FAD to client apo-flavoproteins. The balance between FAD synthesis and hydrolysis may be regulated by redox-sensing cysteine residues. At a much lower rate, FAD synthase catalyzes the reverse pyrophosphorolytic reaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSN6;Q8BXQ1", "ec_number_list": "3.6.1.22;3.6.1.18;3.6.1.-;2.7.7.2", "go_molecular_function": "GO:0003919 FMN adenylyltransferase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0035529 NADH pyrophosphatase activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006747 FAD biosynthetic process;GO:0006771 riboflavin metabolic process;GO:0006796 phosphate-containing compound metabolic process;GO:0090407 organophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBR2-1", "uniprot_id": "FA13C_MOUSE", "mass": 66981.0, "length": 601, "protein_name": "Protein FAM13C", "gene_name": "Fam13c", "organism": "Mouse", "refseq_name": "protein FAM13C isoform 1", "refseq_ac": "NP_077206", "gene_names_uniprotkb": "Fam13c; Fam13c1", "gene_names_refseq": "1200015N20Rik; C030038O19Rik; Fam13c; mKIAA1796", "protein_names_uniprotkb": "Protein FAM13C", "protein_names_refseq": "protein FAM13C isoform 1; protein FAM13C", "tax_id": 10090, "disease": "", "pathway": " (mmu:71721)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19144319;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3YTZ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DBR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K5B1-1", "uniprot_id": "IL31R_MOUSE", "mass": 80580.0, "length": 716, "protein_name": "Interleukin-31 receptor subunit alpha", "gene_name": "Il31ra", "organism": "Mouse", "refseq_name": "interleukin-31 receptor subunit alpha precursor", "refseq_ac": "NP_647460", "gene_names_uniprotkb": "Il31ra; Glmr", "gene_names_refseq": "CRL3; GLM-R; GPL; Glmr; Il31ra; NR10", "protein_names_uniprotkb": "Interleukin-31 receptor subunit alpha; GLM-R; GPL; Gp130-like monocyte receptor; Gp130-like receptor; IL-31 receptor A; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; NR10; Novel cytokine receptor 10; ZcytoR17; mGLM-R", "protein_names_refseq": "IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; class I cytokine receptor; cytokine receptor NR10; gp130-like monocyte receptor; gp130-like receptor; interleukin 31RA; interleukin-31 receptor subunit alpha precursor; interleukin-31 receptor subunit alpha short peptide; interleukin-31 receptor subunit alpha; mGLM-R; novel cytokine receptor 10; zcytoR17", "tax_id": 10090, "disease": "primary localized cutaneous amyloidosis 2 (Disease Ontology:DOID:0080931)", "pathway": " (mmu:218624); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11877449;14699500;15184896;16926070;17379091;21750661;24373353;25381841;25428506;25847241;38081868", "class_list": "", "function": "Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro., [UniProtKB, UniProtKB]; Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (By similarity). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR. These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated. In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Gp130(757F/F) mice rapidly develop distal stomach tumors, with loss of SHP2/Erk/AP-1 transcriptional regulation exemplified by decreased TFF1 expression and increased STAT1/3 regulated genes such as Reg I., [RefSeq, PubMed]; Interleukin 31 receptor alpha promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ31;Q6EAL6;Q6EAL7;Q6NZF0;Q8BSU3;Q8R501", "ec_number_list": "", "go_molecular_function": "GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0002067 glandular epithelial cell differentiation;GO:0098542 defense response to other organism;GO:0008284 positive regulation of cell population proliferation;GO:0002438 acute inflammatory response to antigenic stimulus;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8K5B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YD3-1", "uniprot_id": "DCP1A_MOUSE", "mass": 65219.0, "length": 602, "protein_name": "mRNA-decapping enzyme 1A", "gene_name": "Dcp1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dcp1a; Mitc1; Smif", "gene_names_refseq": "", "protein_names_uniprotkb": "mRNA-decapping enzyme 1A; 3.6.1.62; MAD homolog 4-interacting transcription coactivator 1; Smad4-interacting transcriptional co-activator; Transcription factor SMIF", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:75901); (R-MMU-430039); (R-MMU-450385); (R-MMU-450513); (R-MMU-975957)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11836524;17242355;19861488;21183079;21750661;22517741;25428506;25605945;30059200;32782141;32848054;33813271;34678516;35822049;36210013;36852467;40021952;40885482", "class_list": "", "function": "Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity). Essential for embryonic development (PubMed:11836524)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZE3", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.4.13;3.1.-.-;4.2.99.18;3.1.3.16;3.1.13.-;3.6.5.-;2.7.11.1;3.1.26.-;5.6.2.3;5.6.2.5;3.6.1.59;3.6.1.52;3.6.1.10;3.6.1.61", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding;GO:0019894 kinesin binding;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0000932 P-body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:1903608 protein localization to cytoplasmic stress granule;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0045893 positive regulation of DNA-templated transcription;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q91YD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61062-1", "uniprot_id": "DVL3_MOUSE", "mass": 78123.0, "length": 716, "protein_name": "Segment polarity protein dishevelled homolog DVL-3", "gene_name": "Dvl3", "organism": "Mouse", "refseq_name": "segment polarity protein dishevelled homolog DVL-3 isoform 1", "refseq_ac": "NP_031915", "gene_names_uniprotkb": "Dvl3", "gene_names_refseq": "Dvl3; b2b2866Clo", "protein_names_uniprotkb": "Segment polarity protein dishevelled homolog DVL-3; DSH homolog 3; Dishevelled-3", "protein_names_refseq": "dishevelled 3, dsh homolog; segment polarity protein dishevelled homolog DVL-3 isoform 1; segment polarity protein dishevelled homolog DVL-3", "tax_id": 10090, "disease": "autosomal dominant Robinow syndrome 3 (Disease Ontology:DOID:0060767); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:13544); (R-MMU-201688); (R-MMU-4086400); (R-MMU-4641258); (R-MMU-4641262); (R-MMU-5663220)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "12805222;15456783;21750661;22227309;31219806;37501340;8922524", "class_list": "", "function": "Involved in the signal transduction pathway mediated by multiple Wnt genes., [UniProtKB, PubMed]; Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E820", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046330 positive regulation of JNK cascade;GO:0032880 regulation of protein localization;GO:0045893 positive regulation of DNA-templated transcription;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61062-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UYI6-1", "uniprot_id": "FUZZY_MOUSE", "mass": 45588.0, "length": 415, "protein_name": "Protein fuzzy homolog", "gene_name": "Fuz", "organism": "Mouse", "refseq_name": "protein fuzzy homolog isoform 2", "refseq_ac": "NP_081652", "gene_names_uniprotkb": "Fuz", "gene_names_refseq": "2600013E07Rik; Fuz; b2b1273Clo", "protein_names_uniprotkb": "Protein fuzzy homolog", "protein_names_refseq": "protein fuzzy homolog isoform 2; protein fuzzy homolog", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (mmu:70300); (R-MMU-5610787)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19767740;19877275;20962855;21750661;27158779;35427153;37794731;39369306", "class_list": "", "function": "Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia., [RefSeq, PubMed]; Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals., [RefSeq, PubMed]; Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development., [RefSeq, PubMed]; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:19767740, PubMed:19877275, PubMed:27158779). May regulate the morphogenesis of hair follicles which depends on functional primary cilia (PubMed:20962855). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (PubMed:35427153)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0P9", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005929 cilium", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0090301 negative regulation of neural crest formation;GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0021513 spinal cord dorsal/ventral patterning;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UYI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4X7-1", "uniprot_id": "MNARL_MOUSE", "mass": 21854.0, "length": 193, "protein_name": "Major intrinsically disordered NOTCH2-binding receptor 1-like homolog", "gene_name": "Minar2", "organism": "Mouse", "refseq_name": "major intrinsically disordered NOTCH2-binding receptor 1-like homolog isoform a", "refseq_ac": "NP_776120", "gene_names_uniprotkb": "Minar2; A730017C20Rik", "gene_names_refseq": "A730017C20Rik; Minar2", "protein_names_uniprotkb": "Major intrinsically disordered NOTCH2-binding receptor 1-like homolog; Major intrinsically disordered NOTCH2-associated receptor 2; Membrane integral NOTCH2-associated receptor 2", "protein_names_refseq": "UPF0258 protein KIAA1024-like homolog; major intrinsically disordered NOTCH2-associated receptor 2; major intrinsically disordered NOTCH2-binding receptor 1-like homolog isoform a; major intrinsically disordered Notch2-binding receptor 1-like homolog", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:225583)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15345747;21750661;32954300;35727972;37245847", "class_list": "", "function": "Binds cholesterol and may regulate the distribution and homeostasis of cholesterol in hair cells (By similarity). May play a role in angiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Erratum:[Mol Metab. 2025 Jul;97:102160. doi: 10.1016/j.molmet.2025.102160. PMID: 40345243], [RefSeq, PubMed]; Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0Q0;E9Q5J6;Q6DI98", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032420 stereocilium;GO:0012505 endomembrane system", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0001525 angiogenesis;GO:0007626 locomotory behavior;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C4X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70348-1", "uniprot_id": "DXO_MOUSE", "mass": 45280.0, "length": 397, "protein_name": "Decapping and exoribonuclease protein", "gene_name": "Dxo", "organism": "Mouse", "refseq_name": "decapping and exoribonuclease protein isoform 1", "refseq_ac": "NP_001157242", "gene_names_uniprotkb": "Dxo; Dom3z; Ng6", "gene_names_refseq": "Dom3z; Dxo; NG6", "protein_names_uniprotkb": "Decapping and exoribonuclease protein; 3.1.13.-; 3.6.1.-; 5'-3' exoribonuclease DXO; DXO; DeNADding enzyme DXO; Dom-3 homolog Z; NAD-capped RNA hydrolase DXO", "protein_names_refseq": "5'-3' exoribonuclease DXO; NAD-capped RNA hydrolase DXO; deNADding enzyme DXO; decapping and exoribonuclease protein isoform 1; decapping and exoribonuclease protein; protein Dom3Z", "tax_id": 10090, "disease": "", "pathway": " (mmu:112403)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14656967;19194460;21183079;21750661;23523372;28283058;30180947;31777937;32374864;32432673", "class_list": "", "function": "A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes has been reported. Erratum:[Nucleic Acids Res. 2021 Jul 21;49(13):7806. doi: 10.1093/nar/gkab570. PMID: 34165569], [RefSeq, PubMed]; DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs., [RefSeq, PubMed]; Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Report Dom3Z has role in pre-mRNA 5' end capping quality control mechanism and suggest link between proper 5' end capping and subsequent pre-mRNA processing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KD8", "ec_number_list": "3.1.13.-;3.6.1.-;3.6.1.62;3.6.1.64", "go_molecular_function": "GO:0034353 mRNA 5'-diphosphatase activity;GO:0000287 magnesium ion binding;GO:0003729 mRNA binding;GO:0000166 nucleotide binding;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0050779 RNA destabilization;GO:0071028 nuclear mRNA surveillance;GO:0006402 mRNA catabolic process;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0110155 NAD-cap decapping", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70348-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14B80-1", "uniprot_id": "KCNC2_MOUSE", "mass": 70503.0, "length": 642, "protein_name": "Voltage-gated potassium channel KCNC2", "gene_name": "Kcnc2", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel KCNC2 isoform 1", "refseq_ac": "NP_001346681", "gene_names_uniprotkb": "Kcnc2", "gene_names_refseq": "B230117I07; KShIIIA; Kcnc2; Kv3.2", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC2; Potassium voltage-gated channel subfamily C member 2; Shaw-like potassium channel; Voltage-gated potassium channel Kv3.2", "protein_names_refseq": "potassium voltage-gated channel subfamily C member 2; shaw-like potassium channel; voltage-gated potassium channel KCNC2 isoform 1; voltage-gated potassium channel KCNC2; voltage-gated potassium channel Kv3.2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 103 (Disease Ontology:DOID:0070389); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:268345); (R-MMU-1296072); (R-MMU-381676)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10414303;10531438;10561420;10903572;11124984;11506885;12000114;15317859;15852012;15917463;17761775;21183079;21414897;21750661;21912965;22539821", "class_list": "", "function": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10414303, PubMed:10561420, PubMed:10903572, PubMed:11124984, PubMed:11506885, PubMed:15317859, PubMed:15917463, PubMed:17761775, PubMed:21414897). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:10414303, PubMed:10561420, PubMed:10903572, PubMed:15317859). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10531438, PubMed:12000114). Channel properties may be modulated by either the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in thalamocortical and suprachiasmatic nucleus (SCN) neurons, in hippocampal and neocortical interneurons and in retinal ganglion cells (PubMed:10561420, PubMed:10903572, PubMed:11506885, PubMed:17761775). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner (PubMed:10903572). Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release (PubMed:15917463). Required for long-range synchronization of gamma oscillations over distance in the neocortex (PubMed:22539821). Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (PubMed:21414897)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0071242 cellular response to ammonium ion;GO:1990089 response to nerve growth factor;GO:0045471 response to ethanol;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q14B80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LB2-1", "uniprot_id": "DHRS4_MOUSE", "mass": 29885.0, "length": 279, "protein_name": "Dehydrogenase/reductase SDR family member 4", "gene_name": "Dhrs4", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 4 isoform 1", "refseq_ac": "NP_001033027", "gene_names_uniprotkb": "Dhrs4; D14Ucla2", "gene_names_refseq": "CR; D14Ucla2; Dhrs4; NDRD; PHCR; PSCD; RRD; mouNRDR", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 4; 1.1.1.184; 1.1.1.300; CR; NADPH-dependent carbonyl reductase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; PSCD; Peroxisomal short-chain alcohol dehydrogenase; Protein SDR25C2; Short chain dehydrogenase/reductase family 25C member 2; mouNRDR", "protein_names_refseq": "NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase SDR family member 4 isoform 1; peroxisomal short-chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 25C member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:28200); (R-MMU-5365859); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;23036705;23576753;23806337;27323117;31219806;34428180;37453647;37507081;39927985", "class_list": "", "function": "An analysis of the relationship between the promoter characteristics and RNA expression of the DHRS4 gene cluster indicated that the development of CpG islands, in addition to the promoter sequence, during mammalian evolution could modulate the dose compensatory regulation of the copy number-varied DHRS4 gene cluster Publication Status: Online-Only, [RefSeq, PubMed]; M. musculus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. M. musculus genes are orthologs of human DHRS2 and DHRS4 genes respectively., [RefSeq, PubMed]; NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3X8V7;Q9EQU4", "ec_number_list": "1.1.1.184;2.3.2.27;1.1.1.300;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;1.1.1.21;1.1.1.372;1.1.1.54;2.3.1.137;2.3.1.7;1.1.1.189;1.1.1.197;1.1.1.196;1.1.1.71;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;1.1.1.-;2.3.1.42;1.5.3.13;1.6.5.10;2.3.1.65;1.4.3.1;4.1.1.9;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0018455 alcohol dehydrogenase [NAD(P)+] activity;GO:0042802 identical protein binding;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0042574 retinal metabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99LB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TS7-1", "uniprot_id": "DEND_MOUSE", "mass": 76407.0, "length": 710, "protein_name": "Dendrin", "gene_name": "Ddn", "organism": "Mouse", "refseq_name": "dendrin", "refseq_ac": "NP_001013763", "gene_names_uniprotkb": "Ddn; Gm748; Kiaa0749", "gene_names_refseq": "Ddn; Gm748", "protein_names_uniprotkb": "Dendrin", "protein_names_refseq": "dendrin", "tax_id": 10090, "disease": "", "pathway": " (mmu:13199)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17251388;17537921;18356187;21183079;21606645;21750661;24376653;26073036;32848054;37134307;40885482", "class_list": "", "function": "Ablation of the podocyte death-promoting protein dendrin delays onset of end-stage kidney disease, thereby expanding the life span of mice lacking the adapter protein CD2AP. Ablation of dendrin delays onset and severity of proteinuria and podocyte loss., [RefSeq, PubMed]; Dendrin is dispensable for the function of the normal glomerular filtration barrier, and it interacts with Wtip and Gadd45a. Publication Status: Online-Only, [RefSeq, PubMed]; In glomerulogenesis, dendrin mRNA and protein appeared first at the early capillary loop stage. It was concentrated to the pre-podocytes on the basal side of podocalyxin, an apical cell membrane marker., [RefSeq, PubMed]; Inhibition of Importin- alpha -Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis., [RefSeq, PubMed]; Nuclear relocation of dendrin promotes apoptosis of podocytes., [RefSeq, PubMed]; Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein., [UniProtKB, PubMed]; Relocation of dendrin from the slit diaphragm to the podocyte nucleus in adriamycin-induced glomerulosclerosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPT2;Q3TY46", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80TS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A088MLT8-1", "uniprot_id": "IQIP1_MOUSE", "mass": 61917.0, "length": 559, "protein_name": "IQCJ-SCHIP1 readthrough transcript protein", "gene_name": "Iqcj-Schip1", "organism": "Mouse", "refseq_name": "IQCJ-SCHIP1 readthrough transcript protein", "refseq_ac": "NP_001106890", "gene_names_uniprotkb": "Iqcj-Schip1; Iqschfp; Schip1", "gene_names_refseq": "Gm21949; Iqcj-schip1; Iqschfp; Schip-1-iqcj; Schip1", "protein_names_uniprotkb": "IQCJ-SCHIP1 readthrough transcript protein", "protein_names_refseq": "IQ motif containing J-schwannomin interacting protein 1 fusion protein; IQ motif containing J-schwannomin interacting protein 1 readthrough; IQCJ-SCHIP1 readthrough transcript protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100505386)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18550753;25950943;25953347;27979964;34678516", "class_list": "", "function": "May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943, PubMed:25953347, PubMed:27979964). May also play a role in axon outgrowth and guidance (PubMed:25953347)., [UniProtKB, PubMed, PubMed, PubMed]; This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (Iqcj) and schwannomin interacting protein 1 (Schip1) genes. This locus produces a transcript that is composed of in-frame exons from each individual gene. The resulting fusion protein is thought to be a component of the multimolecular complexes of axon initial segments and nodes of Ranvier, and it may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8IJC6;A8IJD0;A8IJD3;F6YL02;F8WI70;Q3TI53;Q52KH1;Q6P9Y8;Q9CX07;Q9JLR0", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0044325 transmembrane transporter binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0033268 node of Ranvier;GO:0043194 axon initial segment", "go_biological_process": "GO:0051494 negative regulation of cytoskeleton organization;GO:0008366 axon ensheathment;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A088MLT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERS7-1", "uniprot_id": "ILRL2_MOUSE", "mass": 65108.0, "length": 574, "protein_name": "Interleukin-1 receptor-like 2", "gene_name": "Il1rl2", "organism": "Mouse", "refseq_name": "interleukin-1 receptor-like 2 precursor", "refseq_ac": "NP_573456", "gene_names_uniprotkb": "Il1rl2", "gene_names_refseq": "IL-1Rrp2; Il1rl2", "protein_names_uniprotkb": "Interleukin-1 receptor-like 2; 3.2.2.6; IL-1Rrp2; IL-36 receptor; IL1R-rp2; Interleukin-1 receptor-related protein 2", "protein_names_refseq": "IL-36 receptor; IL1R-rp2; interleukin-1 receptor related protein 2; interleukin-1 receptor-like 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:107527); (R-MMU-9007892); (R-MMU-9014826)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10882729;21750661;21860022;21965679;23064362;38727323", "class_list": "", "function": "Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.5;2.4.2.31;3.2.2.6;2.4.99.20;3.2.2.-", "go_molecular_function": "GO:0004909 interleukin-1, type I, activating receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0004896 cytokine receptor activity;GO:0004908 interleukin-1 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ERS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPL8-1", "uniprot_id": "IPO7_MOUSE", "mass": 119486.0, "length": 1038, "protein_name": "Importin-7", "gene_name": "Ipo7", "organism": "Mouse", "refseq_name": "importin-7 isoform 1", "refseq_ac": "NP_852658", "gene_names_uniprotkb": "Ipo7; Ranbp7", "gene_names_refseq": "A330055O14Rik; C330016G14; Imp7; Ipo7; Ranbp7", "protein_names_uniprotkb": "Importin-7; Imp7; Ran-binding protein 7; RanBP7", "protein_names_refseq": "RAN binding protein 7; importin-7 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233726)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11493596;11528126;21183079;21750661;25428506;25605945;28315936;30084848;31219806;31599954;33300544;33548622;34428180;34995814;35820727;35922041;37004548;37828378;39627609", "class_list": "", "function": "Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level., [RefSeq, PubMed]; Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (PubMed:33548622, PubMed:35922041). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (PubMed:34995814). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (PubMed:35922041). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (PubMed:35922041). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (PubMed:11493596)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation., [RefSeq, PubMed]; Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38., [RefSeq, PubMed]; The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN09;Q7TQ63;Q8BKD8;Q8BYI0", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0046332 SMAD binding;GO:0042393 histone binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1901331 positive regulation of odontoblast differentiation;GO:0045087 innate immune response;GO:1900182 positive regulation of protein localization to nucleus;GO:0045668 negative regulation of osteoblast differentiation;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9EPL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FD9-1", "uniprot_id": "K1549_MOUSE", "mass": 209221.0, "length": 1940, "protein_name": "UPF0606 protein KIAA1549", "gene_name": "D630045J12Rik; Kiaa1549", "organism": "Mouse", "refseq_name": "UPF0606 protein KIAA1549 precursor", "refseq_ac": "NP_918950", "gene_names_uniprotkb": "D630045J12Rik; Kiaa1549", "gene_names_refseq": "D630045J12Rik; Kiaa1549; mKIAA1549", "protein_names_uniprotkb": "UPF0606 protein KIAA1549", "protein_names_refseq": "UPF0606 protein KIAA1549 precursor", "tax_id": 10090, "disease": "retinitis pigmentosa 86 (Disease Ontology:DOID:0112143)", "pathway": " (mmu:330286)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;21750661;22645316;26495903;30120214;30899004;32848054;33300544;37828378;40885482", "class_list": "", "function": "May play a role in photoreceptor function., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPN1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q68FD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DU25-1", "uniprot_id": "IQEC2_MOUSE", "mass": 161787.0, "length": 1478, "protein_name": "IQ motif and SEC7 domain-containing protein 2", "gene_name": "Iqsec2", "organism": "Mouse", "refseq_name": "IQ motif and SEC7 domain-containing protein 2 isoform X4", "refseq_ac": "XP_006528908", "gene_names_uniprotkb": "Iqsec2; Kiaa0522", "gene_names_refseq": "Brag1; Iqsec2", "protein_names_uniprotkb": "IQ motif and SEC7 domain-containing protein 2", "protein_names_refseq": "IQ motif and SEC7 domain-containing protein 2 isoform X4", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 1 (Disease Ontology:DOID:0112038)", "pathway": " (mmu:245666)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16452087;18034455;19144319;21183079;21750661;22645316;24129315;25428507;30059200;34418053", "class_list": "", "function": "Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QK46", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0099092 postsynaptic density, intracellular component;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0051965 positive regulation of synapse assembly;GO:0016192 vesicle-mediated transport;GO:0050804 modulation of chemical synaptic transmission;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5DU25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ21-1", "uniprot_id": "KAT6A_MOUSE", "mass": 224919.0, "length": 2003, "protein_name": "Histone acetyltransferase KAT6A", "gene_name": "Kat6a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kat6a; Moz; Myst3", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone acetyltransferase KAT6A; 2.3.1.48; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MOZ; MYST-3; Monocytic leukemia zinc finger homolog; Monocytic leukemia zinc finger protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "Arboleda-Tham syndrome (Disease Ontology:DOID:0070062); DiGeorge syndrome (Disease Ontology:DOID:11198); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:244349); (R-MMU-3214847); (R-MMU-6804758)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11742995;19144319;21183079;21750661;23806337;30084848;31219806;34428180;34678516;36852467;40997131", "class_list": "", "function": "Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (By similarity). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (PubMed:11742995). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity). May play a role in leukemogenic gene transcription (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BW52;Q8BYH1;Q8C1F3", "ec_number_list": "2.3.1.48;2.3.1.-;3.5.1.-;3.5.1.98;2.7.11.1;3.6.4.-;2.3.1.259;2.3.1.57;2.3.1.80;4.2.1.-", "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016605 PML body", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0035162 embryonic hemopoiesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BZ21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35174-1", "uniprot_id": "KCNS2_MOUSE", "mass": 54289.0, "length": 477, "protein_name": "Delayed-rectifier potassium channel regulatory subunit KCNS2", "gene_name": "Kcns2", "organism": "Mouse", "refseq_name": "delayed-rectifier potassium channel regulatory subunit KCNS2", "refseq_ac": "NP_001258633", "gene_names_uniprotkb": "Kcns2", "gene_names_refseq": "E130006J24Rik; Kcns2; Kv9.2", "protein_names_uniprotkb": "Delayed-rectifier potassium channel regulatory subunit KCNS2; Delayed-rectifier K(+) channel alpha subunit 2; Delayed-rectifier potassium channel subunit Kv9.2; Potassium voltage-gated channel subfamily S member 2", "protein_names_refseq": "delayed-rectifier K(+) channel alpha subunit 2; delayed-rectifier potassium channel regulatory subunit KCNS2; delayed-rectifier potassium channel subunit Kv9.2; potassium voltage-gated channel subfamily S member 2; voltage-gated potassium channel subunit Kv9.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16539); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9305895", "class_list": "", "function": "Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values (PubMed:9305895). While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2 (PubMed:9305895). Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process (PubMed:9305895)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543P3", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04104-1", "uniprot_id": "K2C1_MOUSE", "mass": 65606.0, "length": 637, "protein_name": "Keratin, type II cytoskeletal 1", "gene_name": "Krt1", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 1", "refseq_ac": "NP_032499", "gene_names_uniprotkb": "Krt1; Krt2-1", "gene_names_refseq": "Krt-2.1; Krt1; Krt2-1; Krt86", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 1; 67 kDa cytokeratin; CK-1; Cytokeratin-1; K1; Keratin-1; Type-II keratin Kb1", "protein_names_refseq": "67 kDa cytokeratin; CK-1; K1; cytokeratin-1; keratin 86; keratin complex 2, basic, gene 1; keratin, type II cytoskeletal 1; type-II keratin Kb1", "tax_id": 10090, "disease": "KRT1-related nonepidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0070550); epidermolytic palmoplantar keratoderma 2 (Disease Ontology:DOID:0070551); keratosis palmoplantaris striata 3 (Disease Ontology:DOID:0081110); epidermolytic hyperkeratosis 1 (Disease Ontology:DOID:0081358); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603)", "pathway": " (mmu:16678); (R-MMU-6798695); (R-MMU-6805567); (R-MMU-6809371); (R-MMU-9855719); (R-MMU-9970672)", "pathway_count": 6, "publication_count": 24, "publication_id_list": "11408584;11841545;16528356;21183079;22645316;24129315;24751727;24940650;25428506;2581964;26495903;27802388;28011936;31219806;32069316;32152506;34428180;34887587;35820727;36064721;36583994;37453647;37828378;39627609", "class_list": "", "function": "Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers with a type I keratin, assembling into keratin intermediate filament networks that provide mechanical strength and structural stability to differentiating epidermal cells. May regulate the activity of kinases such as PKC and SRC by interacting with integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP, acts as a high-affinity receptor for kininogen-1 (HMWK)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q149E0;Q9D2K8", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0030246 carbohydrate binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0061436 establishment of skin barrier;GO:0050728 negative regulation of inflammatory response;GO:0051290 protein heterotetramerization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P04104-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05784-1", "uniprot_id": "K1C18_MOUSE", "mass": 47538.0, "length": 423, "protein_name": "Keratin, type I cytoskeletal 18", "gene_name": "Krt18", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 18", "refseq_ac": "NP_034794", "gene_names_uniprotkb": "Krt18; Kerd; Krt1-18", "gene_names_refseq": "CK18; K18; Krt1-18; Krt18", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 18; CK-18; Cytokeratin endo B; Cytokeratin-18; K18; Keratin D; Keratin-18", "protein_names_refseq": "cytokeratin endo B; cytokeratin-18; keratin D; keratin complex 1, acidic, gene 18; keratin, type I cytoskeletal 18", "tax_id": 10090, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary biliary cholangitis (Disease Ontology:DOID:12236); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:16668); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;1691189;16973199;17213200;17242355;20724476;21183079;2416755;2454868;2467843;24940650;25617501;28011936;30042374;31616917;32152506;32848054;34428180;36210013;37453647;39169838;39627609;7504637;7507912;9298992", "class_list": "", "function": "Skeletal muscle adaptations following eccentric contractions are not mediated by keratin 18., [RefSeq, PubMed]; Structural component of intermediate filaments in simple epithelial cells. Forms obligate heteropolymers with a type II keratin KRT8, mechanical stability and resilience to epithelial cells (PubMed:1691189). KRT8/KRT18 filaments are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (By similarity). Organization and orientation of KRT8/KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules (By similarity). Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading (By similarity). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane (By similarity). Involved in interleukin-6 (IL-6)-mediated barrier protection (PubMed:17213200)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIX1;Q3TJH6;Q3TJW7;Q61766", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0097191 extrinsic apoptotic signaling pathway;GO:0043001 Golgi to plasma membrane protein transport;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0097284 hepatocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P05784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07744-1", "uniprot_id": "K2C4_MOUSE", "mass": 56283.0, "length": 525, "protein_name": "Keratin, type II cytoskeletal 4", "gene_name": "Krt4", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 4", "refseq_ac": "NP_032501", "gene_names_uniprotkb": "Krt4; Krt2-4", "gene_names_refseq": "K4; Krt-2.4; Krt2-4; Krt4", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 4; CK-4; Cytokeratin-4; Cytoskeletal 57 kDa keratin; K4; Keratin-4; Type-II keratin Kb4", "protein_names_refseq": "57kDa keratin; 57kd keratin; CK-4; cytokeratin-4; cytoskeletal 57 kDa keratin; keratin complex 2, basic, gene 4; keratin, type II cytoskeletal 4; type-II keratin Kb4", "tax_id": 10090, "disease": "white sponge nevus (Disease Ontology:DOID:0050448); white sponge nevus 1 (Disease Ontology:DOID:0081287)", "pathway": " (mmu:16682); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "24129315;2418416;34019948;34428180;36583994;37507081", "class_list": "", "function": "Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type I keratin KRT13, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6D6;Q6P3F5", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0009986 cell surface;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0031424 keratinization;GO:0050680 negative regulation of epithelial cell proliferation;GO:0007010 cytoskeleton organization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTW7-1", "uniprot_id": "RESF1_MOUSE", "mass": 169044.0, "length": 1521, "protein_name": "Retroelement silencing factor 1", "gene_name": "Resf1", "organism": "Mouse", "refseq_name": "retroelement silencing factor 1", "refseq_ac": "NP_001276590", "gene_names_uniprotkb": "Resf1; 2810474O19Rik; Kiaa1551", "gene_names_refseq": "2810474O19Rik; 6720435I21Rik; GET; Resf1", "protein_names_uniprotkb": "Retroelement silencing factor 1", "protein_names_refseq": "likely orthologue of H. sapiens chromosome 12 open reading frame 35 (C12orf35); retroelement silencing factor 1; uncharacterized protein C12orf35 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67246)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21183079;21606357;21750661;29728365;31219806;32782141;34428180;34607919;34678516;36852467;38722825;40997131", "class_list": "", "function": "Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells., [UniProtKB, PubMed]; Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWH0;Q7TNT1;Q8CCW3;Q8CCZ9;Q9CSA5;Q9CU82", "ec_number_list": "", "go_molecular_function": "GO:1990226 histone methyltransferase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0009617 response to bacterium;GO:0141005 transposable element silencing by heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q5DTW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IFZ6-1", "uniprot_id": "K2C1B_MOUSE", "mass": 61359.0, "length": 572, "protein_name": "Keratin, type II cytoskeletal 1b", "gene_name": "Krt77", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 1b", "refseq_ac": "NP_001003667", "gene_names_uniprotkb": "Krt77; Krt1b", "gene_names_refseq": "4732484G22Rik; CK-1B; K1emb; K77; Krt239; Krt77; mK1b", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 1b; CK-1B; Cytokeratin-1B; Embryonic type II keratin-1; K77; Keratin-77; Type-II keratin Kb39", "protein_names_refseq": "cytokeratin-1B; embryonic type II keratin 1; keratin 1b; keratin complex 2, basic, gene 39; keratin, type II cytoskeletal 1b; type II keratin Kb39; type-II intermediate filament protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:406220); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15085952;15619433;17330888;24129315;28011936;34428180;34887587;39603462;41018975", "class_list": "", "function": "Krt77 is the highest expressed gene among keratins in epidermis embryonic development., [RefSeq, PubMed]; Sequence of novel type II keratin site-specifically deiminated in embryonic mouse epidermis., [RefSeq, PubMed]; Structural component of intermediate filaments in epithelial cells of stratified epithelia. Assembles into heteropolymers with a type I keratin, forming keratin intermediate filament networks contributing to epithelial integrity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6IFZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W32-1", "uniprot_id": "DRC9_MOUSE", "mass": 49168.0, "length": 419, "protein_name": "Dynein regulatory complex protein 9", "gene_name": "Drc9", "organism": "Mouse", "refseq_name": "dynein regulatory complex protein 9", "refseq_ac": "NP_848465", "gene_names_uniprotkb": "Drc9; Iqcg", "gene_names_refseq": "2400003L07Rik; Drc9; G1-374-12; Iqcg; esgd12d; repro1; stubby12d", "protein_names_uniprotkb": "Dynein regulatory complex protein 9; IQ domain-containing protein G", "protein_names_refseq": "IQ domain-containing protein G; dynein regulatory complex protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:69707)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24362311;24787902;24849454;25428506;35547804", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (By similarity). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility (PubMed:24362311, PubMed:24849454)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Iqcg is specifically required for spermiogenesis in mammals Publication Status: Online-Only, [RefSeq, PubMed]; Loss of Iqcg disrupts spermiogenesis such that tail formation either occurs incompletely or breaks apart from the sperm heads. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0031514 motile cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007286 spermatid development;GO:0044782 cilium organization;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80W32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP00-1", "uniprot_id": "IQCB1_MOUSE", "mass": 68734.0, "length": 598, "protein_name": "IQ calmodulin-binding motif-containing protein 1", "gene_name": "Iqcb1", "organism": "Mouse", "refseq_name": "IQ calmodulin-binding motif-containing protein 1", "refseq_ac": "NP_796102", "gene_names_uniprotkb": "Iqcb1; Kiaa0036", "gene_names_refseq": "6820449I09Rik; Iqcb1; NPHP5", "protein_names_uniprotkb": "IQ calmodulin-binding motif-containing protein 1", "protein_names_refseq": "IQ calmodulin-binding motif-containing protein 1", "tax_id": 10090, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); retinitis pigmentosa 3 (Disease Ontology:DOID:0110414); nephronophthisis (Disease Ontology:DOID:12712); Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:320299); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15723066;21245082;21565611;25428506;27328943;30713422;30779550", "class_list": "", "function": "Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy., [RefSeq, PubMed]; In the Nphp5-/- and cone-only Nphp5-/-; Nrl-/- mice, cone outer segments did not form, but mutant cones continued to express cone pigments in the inner segments without obvious signs of cone cell death. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Nphp5(-/-) photoreceptor degeneration was complete at 1 mo of age but was delayed significantly in Nphp5(-/-);Nrl(-/-) (cone only) retina, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNK4;Q8K306", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0062063 BBSome binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0032391 photoreceptor connecting cilium;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0048496 maintenance of animal organ identity;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:0061824 cytosolic ciliogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BP00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER47-1", "uniprot_id": "KCNH7_MOUSE", "mass": 135062.0, "length": 1195, "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH7", "gene_name": "Kcnh7", "organism": "Mouse", "refseq_name": "voltage-gated inwardly rectifying potassium channel KCNH7", "refseq_ac": "NP_573470", "gene_names_uniprotkb": "Kcnh7; Erg3", "gene_names_refseq": "9330137I11Rik; Kcnh7; Kv11.3; erg3", "protein_names_uniprotkb": "Voltage-gated inwardly rectifying potassium channel KCNH7; ERG-3; Eag-related protein 3; Ether-a-go-go-related gene potassium channel 3; Ether-a-go-go-related protein 3; Potassium voltage-gated channel subfamily H member 7; Voltage-gated potassium channel subunit Kv11.3", "protein_names_refseq": "ERG-3; eag-related protein 3; ether-a-go-go-related gene potassium channel 3; ether-a-go-go-related protein 3; potassium channel protein erg3; potassium voltage-gated channel subfamily H member 7; voltage-gated inwardly rectifying potassium channel KCNH7; voltage-gated potassium channel subunit Kv11.3", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273); epilepsy (Disease Ontology:DOID:1826); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:170738); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;14643686;19359372;21183079;39365861", "class_list": "", "function": "ERG3 K+ channels contribute to threshold excitability of mouse auditory brainstem neurons., [RefSeq, PubMed]; Erg3 gene expression pattern in the developing embryo., [RefSeq, PubMed]; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification., [UniProtKB, UniProtKB]; Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-a-go-go-related gene) K[+] channel subunits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AUY8", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity;GO:0020037 heme binding;GO:0005249 voltage-gated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ER47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z320-1", "uniprot_id": "K1C27_MOUSE", "mass": 49105.0, "length": 448, "protein_name": "Keratin, type I cytoskeletal 27", "gene_name": "Krt27", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 27", "refseq_ac": "NP_034796", "gene_names_uniprotkb": "Krt27; Krt1-c29; c29", "gene_names_refseq": "CK-27; Krt1-c29; Krt27; mIRSa3.1; stpm", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 27; CK-27; Cytokeratin-27; K27; Keratin complex-1, acidic, gene C29; Keratin-27; Type I inner root sheath-specific keratin-K25irs3", "protein_names_refseq": "cytokeratin-27; keratin complex-1, acidic, gene C29; keratin complex-1, gene C29; keratin, type I cytoskeletal 27; type I inner root sheath-specific keratin-K25irs3", "tax_id": 10090, "disease": "", "pathway": " (mmu:16675); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10087197;14996088;17920809;25428506;28011936", "class_list": "", "function": "Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs)., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The mouse type I keratin genes are clustered in a region of chromosome 11. The encoded protein is involved in the formation of intermediate filaments in the inner root sheath. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z320-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55222-1", "uniprot_id": "ILK_MOUSE", "mass": 51373.0, "length": 452, "protein_name": "Scaffold protein ILK", "gene_name": "Ilk", "organism": "Mouse", "refseq_name": "scaffold protein ILK", "refseq_ac": "NP_001155196", "gene_names_uniprotkb": "Ilk; ILK1; ILK2", "gene_names_refseq": "ESTM24; ILK-1; ILK-2; Ilk; p59ILK", "protein_names_uniprotkb": "Scaffold protein ILK; ILK-1; ILK-2; Inactive integrin-linked kinase; p59ILK", "protein_names_refseq": "59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; inactive integrin-linked kinase; integrin binding protein kinase; integrin-linked protein kinase; scaffold protein ILK", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); dilated cardiomyopathy (Disease Ontology:DOID:12930); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526)", "pathway": " (mmu:16202); (R-MMU-446343); (R-MMU-446353)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "16737959;18325335;18483218;20951348;21750661;23806337;25428506;25605945;25738875;26495903;28011936;28528544;30084848;30779550;34428180;35820727;37828378;38077324;38483756;38951739;9366252", "class_list": "", "function": "ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3beta/beta-catenin pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Integrin-Linked Kinase in the Development of Gastric Tumors Induced by Helicobacter pylori: Regulation and Prevention Potential., [RefSeq, PubMed]; Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (By similarity). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (By similarity). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (By similarity). Acts as an upstream effector of both AKT1/PKB and GSK3 (By similarity). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (PubMed:20951348). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (By similarity). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78KK2", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0072697 protein localization to cell cortex;GO:0006468 protein phosphorylation;GO:0007229 integrin-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O55222-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH86-1", "uniprot_id": "GLUCM_MOUSE", "mass": 66366.0, "length": 617, "protein_name": "D-glutamate cyclase, mitochondrial", "gene_name": "Dglucy", "organism": "Mouse", "refseq_name": "D-glutamate cyclase, mitochondrial isoform 2 precursor", "refseq_ac": "NP_663423", "gene_names_uniprotkb": "Dglucy; 9030617O03Rik", "gene_names_refseq": "9030617O03Rik; Dglucy", "protein_names_uniprotkb": "D-glutamate cyclase, mitochondrial; 4.2.1.48", "protein_names_refseq": "D-glutamate cyclase, mitochondrial isoform 2 precursor; D-glutamate cyclase, mitochondrial; UPF0317 protein C14orf159 homolog, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:217830)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23576753;28266638;30084848", "class_list": "", "function": "D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Further analysis of D-glutamate metabolism indicated that 9030617O03Rik is a D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNN0;Q8VC99", "ec_number_list": "4.2.1.48", "go_molecular_function": "GO:0047820 D-glutamate cyclase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006536 glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BH86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZU6-1", "uniprot_id": "DYST_MOUSE", "mass": 834218.0, "length": 7393, "protein_name": "Dystonin", "gene_name": "Dst", "organism": "Mouse", "refseq_name": "dystonin isoform 4", "refseq_ac": "NP_034211", "gene_names_uniprotkb": "Dst; Bpag1; Macf2", "gene_names_refseq": "2310001O04Rik; A830042E19Rik; BP230; BPAG1-n; Bpag1; Bpag; Dst; Macf2; ah; athetoid; dt; mKIAA0728; nmf203; nmf339", "protein_names_uniprotkb": "Dystonin; BPA; Bullous pemphigoid antigen 1; Dystonia musculorum protein; Hemidesmosomal plaque protein; Microtubule actin cross-linking factor 2", "protein_names_refseq": "BPA; dystonia musculorum protein; dystonin isoform 4; hemidesmosomal plaque protein; microtubule actin cross-linking factor 2", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); hereditary sensory and autonomic neuropathy type 6 (Disease Ontology:DOID:0070151); cancer (Disease Ontology:DOID:162); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (mmu:13518); (R-MMU-446107); (R-MMU-9013420); (R-MMU-9013424); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 7, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;10357897;10428034;11514586;14576348;14581450;16289082;16452087;16797530;17161423;17242355;17287360;18250455;18638474;19932097;20209123;21183079;21750661;22645316;25428506;25428507;30084848;31219806;31599954;34203471;34428180;35820727;35984892;36210013;37603210;37883475;38465459;7670468;7736575;8752219;9971739", "class_list": "", "function": "Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity., [UniProtKB, UniProtKB, UniProtKB]; Required for bundling actin filaments around the nucleus., [UniProtKB, UniProtKB, UniProtKB]; Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues. Review article, [RefSeq, PubMed]; The DST gene in neurobiology. Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9PXE5;E9QL23;Q1KP04;Q3I6J6;Q60824;Q60845;Q8K5D4;Q91ZU7;Q91ZU8;Q9WU50;S4R1U5", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0008090 retrograde axonal transport;GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q91ZU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIK4-1", "uniprot_id": "DOCK9_MOUSE", "mass": 235312.0, "length": 2055, "protein_name": "Dedicator of cytokinesis protein 9", "gene_name": "Dock9", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dock9; D14Wsu89e; Kiaa1058; Ziz1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 9; Cdc42 guanine nucleotide exchange factor zizimin-1; Zizimin-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:105445); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-983231)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "17114649;21183079;21750661;22494997;25428506;25729399;25851601;31219806;31599954;34428180;35820727", "class_list": "", "function": "Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:25851601). Overexpression induces filopodia formation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921Y6", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0012505 endomembrane system", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BIK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32037-1", "uniprot_id": "GTR3_MOUSE", "mass": 53479.0, "length": 493, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 3", "gene_name": "Slc2a3", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 3 isoform b", "refseq_ac": "NP_035531", "gene_names_uniprotkb": "Slc2a3; Glut3", "gene_names_refseq": "Glut-3; Glut3; Slc2a3", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 3; GLUT-3; Glucose transporter type 3, brain", "protein_names_refseq": "glucose transporter type 3, brain; solute carrier family 2, facilitated glucose transporter member 3 isoform b", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); acanthosis nigricans (Disease Ontology:DOID:3138); cataract (Disease Ontology:DOID:83); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20527); (R-MMU-189200); (R-MMU-196836); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;1730609;18299400;19349973;21183079;21750661;25605945;26495903;26740625;29187734;33300544;35618043;35810171;38246582", "class_list": "glycogene", "function": "Facilitative glucose transporter (PubMed:35810171). Can also mediate the uptake of various other monosaccharides across the cell membrane (By similarity). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (By similarity). Does not mediate fructose transport (By similarity). Required for mesendoderm differentiation (PubMed:35810171)., [UniProtKB, UniProtKB, PubMed]; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport., [UniProtKB, UniProtKB]; Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation., [UniProtKB, UniProtKB]; LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0019900 kinase binding;GO:0016936 galactoside binding;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0043066 negative regulation of apoptotic process;GO:0015757 galactose transmembrane transport;GO:0015749 monosaccharide transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32037-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ET47-1", "uniprot_id": "ESPN_MOUSE", "mass": 94497.0, "length": 871, "protein_name": "Espin", "gene_name": "Espn", "organism": "Mouse", "refseq_name": "espin isoform 1", "refseq_ac": "NP_997570", "gene_names_uniprotkb": "Espn", "gene_names_refseq": "Espn; je", "protein_names_uniprotkb": "Espin; Ectoplasmic specialization protein", "protein_names_refseq": "actin cytoskeletal regulatory protein; ectoplasmic specialization protein; espin isoform 1; jerker", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 36 (Disease Ontology:DOID:0110494)", "pathway": " (mmu:56226)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10588661;10975527;12598619;14657236;15190118;16569662;19287378;21183079;21455486;21750661;22264607;26754646;26926603;34428180;35844198", "class_list": "", "function": "Espin overexpression causes stereocilia defects and provides an anti-capping effect on actin polymerization., [RefSeq, PubMed]; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:14657236, PubMed:15190118). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486). Involved in the elongation of actin in stereocilia (PubMed:19287378, PubMed:22264607). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (PubMed:26926603)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AK06;A2AK09;A2AK13;B1AWP3;B1AWP6;B1AWQ2;Q6GYS0;Q6GYS1;Q80ZC0;Q80ZC1;Q80ZC2;Q80ZC3;Q9QY27", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0043197 dendritic spine", "go_biological_process": "GO:0030046 parallel actin filament bundle assembly;GO:0051494 negative regulation of cytoskeleton organization;GO:0007626 locomotory behavior;GO:0051017 actin filament bundle assembly;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9ET47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11276-1", "uniprot_id": "FINC_MOUSE", "mass": 272538.0, "length": 2477, "protein_name": "Fibronectin", "gene_name": "Fn1", "organism": "Mouse", "refseq_name": "fibronectin isoform a precursor", "refseq_ac": "NP_034363", "gene_names_uniprotkb": "Fn1", "gene_names_refseq": "E330027I09; Fn-1; Fn1; Fn", "protein_names_uniprotkb": "Fibronectin; FN", "protein_names_refseq": "fibronectin isoform a precursor", "tax_id": 10090, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); spondylometaphyseal dysplasia corner fracture type (Disease Ontology:DOID:0112297); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); submandibular gland disease (Disease Ontology:DOID:12897); VACTERL association (Disease Ontology:DOID:14679); renovascular hypertension (Disease Ontology:DOID:1591); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:14268); (R-MMU-114608); (R-MMU-1474228); (R-MMU-1566977); (R-MMU-202733); (R-MMU-2129379); (R-MMU-216083); (R-MMU-3000170); (R-MMU-3000178); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-381426); (R-MMU-5674135); (R-MMU-8874081); (R-MMU-8957275); (R-MMU-9634597); (R-MMU-9860927)", "pathway_count": 18, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;11737251;1327855;16944957;17242355;17330941;17699513;18630941;19131326;19349973;19656770;21183079;21750661;21768292;21913724;2521606;26954549;29777959;30059200;31219806;3124113;34089617;34428180;36792666;36812915;37507081;37828378;39627609;39927985;40997131;7673336;8299972;9312106;9533887", "class_list": "", "function": "Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (By similarity). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (PubMed:21768292). Participates in the regulation of type I collagen deposition by osteoblasts (PubMed:21768292). Acts as a ligand for the Lilrb4a receptor, inhibiting Fcgr1/CD64-mediated monocyte activation (PubMed:34089617)., [UniProtKB, PubMed, UniProtKB, PubMed]; Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 20, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "G5E8B8;Q61567;Q61568;Q61569;Q64233;Q80UI4", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0005577 fibrinogen complex", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:0051702 biological process involved in interaction with symbiont;GO:0048484 enteric nervous system development;GO:0007044 cell-substrate junction assembly;GO:0007161 calcium-independent cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P11276-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920Q2-1", "uniprot_id": "REV1_MOUSE", "mass": 137341.0, "length": 1249, "protein_name": "Translesion synthesis protein REV1", "gene_name": "Rev1", "organism": "Mouse", "refseq_name": "translesion synthesis protein REV1 isoform 1", "refseq_ac": "NP_062516", "gene_names_uniprotkb": "Rev1; Rev1l", "gene_names_refseq": "1110027I23Rik; Rev1l; Rev1", "protein_names_uniprotkb": "Translesion synthesis protein REV1; 2.7.7.-; Molecular adapter protein REV1; REV1 homolog; Rev1-like terminal deoxycytidyl transferase; Reversionless protein 1 homolog; Template-dependent deoxycytidyl transferase REV1", "protein_names_refseq": "DNA repair protein REV1; REV1 homolog; molecular adapter protein REV1; rev1-like terminal deoxycytidyl transferase; reversionless protein 1 homolog; template-dependent deoxycytidyl transferase REV1; translesion synthesis protein REV1 isoform 1; translesion synthesis protein REV1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56210); (R-MMU-110312); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "11711549;14657033;15653636;16476771;16857592;16982685;21750661;22700975;22859295;27683219;28970491;31219806;34428180;35156394", "class_list": "", "function": "Bifunctional protein involved in the maintenance of genome stability through translesion DNA synthesis (TLS) and antibody diversification via somatic hypermutation (PubMed:14657033, PubMed:16476771, PubMed:22859295). Functions as a molecular adapter protein at stalled DNA replication, coordinating polymerases recruitment, selection, and switching, in a manner independent of its deoxycytidyl transferase activity (PubMed:14657033, PubMed:22859295). At the site of DNA lesion, recruits and mediates the switch between low-fidelity inserter DNA polymerases, such as POLK, that incorporate nucleotides opposite lesions and the extender DNA polymerase zeta complex which continues DNA synthesis from distorted primer termini (PubMed:14657033, PubMed:22859295). In vitro, acts as a template-dependent deoxycytidyl transferase that preferentially incorporates deoxycytidine residues from dCTP to the 3'-end of a DNA primer opposite apurinic/apyrimidinic (AP) site, uracil, undamaged DNA templates (G > A > C > T) and a variety of damaged DNA templates (PubMed:11711549). Opposite template guanine, efficiently incorporates not only dCMP but also non-complementary dGMP and dTMP, with lower efficiency for dAMP, demonstrating low fidelity on undamaged DNA (PubMed:11711549). This catalytic activity has been implicated in somatic hypermutation, likely achieved by incorporation of deoxycytidine opposite abasic sites, generated at cytidines via activation-induced deoxycytidine deaminase (AID)-mediated deamination and uracil DNA glycosylase (UNG) activity, respectively (PubMed:16476771). In addition, exhibits a 5'-deoxyribose-5-phosphate lyase activity in vitro, though its necessity in vivo is not confirmed (PubMed:16476771)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Rev1 contributes to proper mitochondrial function via the PARP-NAD-SIRT1-PGC1A axis. Erratum:[Sci Rep. 2018 Mar 6;8(1):4245. doi: 10.1038/s41598-018-20586-9. PMID: 29511198] Publication Status: Online-Only, [RefSeq, PubMed]; Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females., [RefSeq, PubMed]; The BRCT domain of Rev1 is involved in regulating DNA replication during the mutagenic bypass of spontaneous and induced DNA lesions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXV2", "ec_number_list": "3.4.19.12;2.7.7.7;2.3.2.27;6.3.2.n3;2.7.7.-;6.2.1.-;2.3.2.23", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0035861 site of double-strand break;GO:0090734 site of DNA damage", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006281 DNA repair;GO:0009411 response to UV;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q920Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEF1-1", "uniprot_id": "ASTRA_MOUSE", "mass": 80699.0, "length": 722, "protein_name": "Protein Aster-A", "gene_name": "Gramd1a", "organism": "Mouse", "refseq_name": "protein Aster-A isoform 2", "refseq_ac": "NP_082174", "gene_names_uniprotkb": "Gramd1a; D7Bwg0611e; Kiaa1533", "gene_names_refseq": "1300003M23Rik; D7Bwg0611e; Gramd1a", "protein_names_uniprotkb": "Protein Aster-A; GRAM domain-containing protein 1A", "protein_names_refseq": "GRAM domain-containing protein 1A; protein Aster-A isoform 2; protein Aster-A", "tax_id": 10090, "disease": "", "pathway": " (mmu:52857)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;21913724;27585821;30220461;31219806;32719109", "class_list": "", "function": "Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). May play a role in tumor progression (PubMed:27585821). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U914;Q3UD89;Q69ZH2;Q8BNF1", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0071397 cellular response to cholesterol;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VEF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64347-1", "uniprot_id": "CLCN1_MOUSE", "mass": 109794.0, "length": 994, "protein_name": "Chloride channel protein 1", "gene_name": "Clcn1", "organism": "Mouse", "refseq_name": "chloride channel protein 1", "refseq_ac": "NP_038519", "gene_names_uniprotkb": "Clcn1; Clc1", "gene_names_refseq": "Clc-1; Clc1; Clcn1; SMCC1; adr; mto; myotonia; nmf355", "protein_names_uniprotkb": "Chloride channel protein 1; Chloride channel protein, skeletal muscle; ClC-1", "protein_names_refseq": "arrested development of righting response; chloride channel protein 1; chloride channel protein, skeletal muscle", "tax_id": 10090, "disease": "Becker disease (Disease Ontology:DOID:0081335); Thomsen disease (Disease Ontology:DOID:0081336); myotonia congenita (Disease Ontology:DOID:2106); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:12723); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1659665;18008009;21078869;21149546;21183079;21750661;25428506;31219806;8119941;9321463", "class_list": "", "function": "Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (By similarity) (PubMed:18008009, PubMed:21078869, PubMed:21149546). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (By similarity). Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization. Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ41;Q9QVY5", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0034707 chloride channel complex;GO:0030315 T-tubule;GO:0016020 membrane", "go_biological_process": "GO:0006936 muscle contraction;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0019227 neuronal action potential propagation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHW4-1", "uniprot_id": "EI2BE_MOUSE", "mass": 80086.0, "length": 717, "protein_name": "Translation initiation factor eIF2B subunit epsilon", "gene_name": "Eif2b5", "organism": "Mouse", "refseq_name": "translation initiation factor eIF2B subunit epsilon isoform 1", "refseq_ac": "NP_758469", "gene_names_uniprotkb": "Eif2b5", "gene_names_refseq": "Eif2b5", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon", "protein_names_refseq": "eIF-2B GDP-GTP exchange factor subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon; translation initiation factor eIF-2B subunit epsilon; translation initiation factor eIF2B subunit epsilon isoform 1; translation initiation factor eIF2B subunit epsilon", "tax_id": 10090, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 5 (Disease Ontology:DOID:0070367)", "pathway": " (mmu:224045); (R-MMU-72731)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;12773302;17242355;18630941;18701453;19131326;19144319;20173027;20826436;21183079;21750661;24129315;25428506;30779550;31219806;31599954;34203471;34428180;35820727;36210013;37507081;38454603;39927985", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB]; In vivo base editing of a pathogenic Eif2b5 variant improves vanishing white matter phenotypes in mice., [RefSeq, PubMed]; Inactivation of glycogen synthase kinase 3beta (GSK3beta) by high glucose and high insulin induces increase in synthesis of laminin beta1 via activation of eIF2Bepsilon., [RefSeq, PubMed]; Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha phosphorylation, reduction of eIF2B activity, and inhibition of eIF4F complex formation., [RefSeq, PubMed]; Mouse model of EIF2B-related leukodystrophy; findings provide evidence that hypomorphic Eif2b5 alleles lead to delayed and abnormal development and maintenance of CNS white matter, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU39", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0002183 cytoplasmic translational initiation;GO:0043065 positive regulation of apoptotic process;GO:0021766 hippocampus development;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8CHW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6VGS5-1", "uniprot_id": "DAPLE_MOUSE", "mass": 226535.0, "length": 2009, "protein_name": "Protein Daple", "gene_name": "Ccdc88c", "organism": "Mouse", "refseq_name": "protein Daple isoform 1", "refseq_ac": "NP_080957", "gene_names_uniprotkb": "Ccdc88c; Daple", "gene_names_refseq": "0610010D24Rik; Ccdc88c; Daple; mKIAA1509", "protein_names_uniprotkb": "Protein Daple; Coiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues", "protein_names_refseq": "DVL-binding protein DAPLE; coiled-coil domain-containing protein 88C; dvl-associating protein with a high frequency of leucine residues; protein Daple isoform 1; protein Daple", "tax_id": 10090, "disease": "spinocerebellar ataxia 40 (Disease Ontology:DOID:0050986); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:68339)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14750955;21750661;22643886;29229865;30948426;31219806;34428180;34642354", "class_list": "", "function": "Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules. Publication Status: Online-Only, [RefSeq, PubMed]; Findings indicate that Daple interacts with Dishevelled to direct the Dishevelled/protein kinase lambda protein complex to activate Rac, which in turn mediates the non-canonical Wnt signalling pathway required for cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of Daple, a Dvl-binding protein, that suppresses Wnt signalling pathway., [RefSeq, PubMed]; Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling. Promotes apical constriction of cells via ARHGEF18., [UniProtKB, UniProtKB]; Results suggest that the primary cilium or an associated structure influences the domain of cell-intrinsic signals that shape the hair bundle. Daple is therefore essential to orient and pattern sensory hair bundles., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVI2", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0008017 microtubule binding;GO:0046983 protein dimerization activity;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030054 cell junction", "go_biological_process": "GO:1902691 respiratory basal cell differentiation;GO:0046330 positive regulation of JNK cascade;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0007264 small GTPase-mediated signal transduction;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6VGS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64368-1", "uniprot_id": "DAZL_MOUSE", "mass": 33313.0, "length": 298, "protein_name": "Deleted in azoospermia-like", "gene_name": "Dazl", "organism": "Mouse", "refseq_name": "deleted in azoospermia-like isoform 2", "refseq_ac": "NP_001264792", "gene_names_uniprotkb": "Dazl; Dazl1; Dazla", "gene_names_refseq": "Daz-like; Dazh; Dazl1; Dazla; Dazl; Tpx-2; Tpx2", "protein_names_uniprotkb": "Deleted in azoospermia-like; DAZ-like autosomal; Deleted in azoospermia-like 1", "protein_names_refseq": "DAZ-like autosomal; deleted in azoospermia-like 1; deleted in azoospermia-like isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13164)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10903443;11410654;15378723;21750661;22021443;23298641;36852467;8661148;8679003;8845845;9288969", "class_list": "", "function": "Alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8., [RefSeq, PubMed]; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005840 ribosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007147 female meiosis II;GO:0045836 positive regulation of meiotic nuclear division;GO:0007283 spermatogenesis;GO:0001556 oocyte maturation;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q64368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61214-1", "uniprot_id": "DYR1A_MOUSE", "mass": 85494.0, "length": 763, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 1A", "gene_name": "Dyrk1a", "organism": "Mouse", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1", "refseq_ac": "NP_001106860", "gene_names_uniprotkb": "Dyrk1a; Dyrk", "gene_names_refseq": "2310043O08Rik; D16Ertd272e; D16Ertd493e; Dyrk1a; Dyrk; Gm10783; Mnbh; Mp86; mmb", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 1A; 2.7.11.23; 2.7.12.1; Dual specificity YAK1-related kinase; MNBH; MP86; Protein kinase minibrain homolog", "protein_names_refseq": "dual specificity YAK1-related kinase; dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a; protein kinase minibrain homolog", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 7 (Disease Ontology:DOID:0070037); intellectual disability (Disease Ontology:DOID:1059); dilated cardiomyopathy (Disease Ontology:DOID:12930); Down syndrome (Disease Ontology:DOID:14250); renovascular hypertension (Disease Ontology:DOID:1591); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:13548); (R-MMU-1538133)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15199138;18034455;18938227;20123978;20167603;21183079;21750661;22998443;25428506;34428180;8975710;9070862", "class_list": "", "function": "Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:18938227, PubMed:20123978). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (By similarity). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (By similarity). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (By similarity). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (PubMed:20167603). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (PubMed:20167603). This in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (PubMed:18938227)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9C475", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.10.1;2.7.12.1;2.7.11.22;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0010629 negative regulation of gene expression;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61214-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47811-1", "uniprot_id": "MK14_MOUSE", "mass": 41287.0, "length": 360, "protein_name": "Mitogen-activated protein kinase 14", "gene_name": "Mapk14", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 14 isoform 2", "refseq_ac": "NP_001161980", "gene_names_uniprotkb": "Mapk14; Crk1; Csbp1; Csbp2", "gene_names_refseq": "CSBP2; Crk1; Csbp1; Mapk14; Mxi2; PRKM14; PRKM15; p38-alpha; p38MAPK; p38alpha; p38a; p38", "protein_names_uniprotkb": "Mitogen-activated protein kinase 14; 2.7.11.24; CRK1; MAP kinase 14; MAP kinase p38 alpha; MAPK 14; Mitogen-activated protein kinase p38 alpha", "protein_names_refseq": "MAP kinase 14; MAP kinase p38 alpha; MAPK 14; mitogen-activated protein kinase 14 isoform 2; mitogen-activated protein kinase p38 alpha; p38 MAP kinase alpha; p38 MAPK", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); gastric adenocarcinoma (Disease Ontology:DOID:3717); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:26416); (R-MMU-168638); (R-MMU-171007); (R-MMU-198753); (R-MMU-2559580); (R-MMU-418592); (R-MMU-432142); (R-MMU-4420097); (R-MMU-450302); (R-MMU-450341); (R-MMU-525793); (R-MMU-5668599); (R-MMU-6798695); (R-MMU-6804756); (R-MMU-69601); (R-MMU-9824585)", "pathway_count": 16, "publication_count": 83, "publication_id_list": "10601328;10704466;10943842;11909979;12086621;12391307;12452429;15735649;15837310;15837333;16288922;16751104;17055984;17242355;17371971;17395714;17947660;18034455;18437630;18669639;18835932;19011223;19619499;20070884;20386595;20626350;20844314;21183079;21533046;21715315;21750661;22069638;22375048;22415879;23536762;24023826;25034973;25147596;25635535;25839158;26020972;26194913;26247726;26289811;26542706;27233083;27239443;27375022;27789289;27902771;28066266;28173800;28329851;28537905;29085990;29141658;29368134;29864522;30202652;30210577;30524949;30609248;30693443;31219806;31243298;31293510;31641103;31653890;31780635;31780731;32164260;32433643;34366869;34428180;35477177;36210013;37507081;39197168;39299237;7839144;7914033;8444355;9122194", "class_list": "", "function": "Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis., [RefSeq, PubMed]; Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Phosphorylates S100A9 at 'Thr-113' (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KF37;B2KF38;O08666;Q3U6R5;Q3UZS3;Q8C289;Q9JLV8;Q9QZ80", "ec_number_list": "2.7.11.1;2.7.11.25;2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;2.7.11.24;2.7.12.2;3.4.22.52;2.7.12.1;2.7.11.22;3.4.19.12;2.7.10.2;2.7.11.-;2.7.11.4;3.4.22.27;2.7.11.10;1.1.1.42;3.4.21.46;4.1.2.13;2.7.11.11;5.3.1.9;5.1.3.-;3.6.4.10;2.7.11.26;2.7.11.19;2.4.2.7;2.7.11.17;2.7.2.3;1.16.3.1;2.7.11.12;3.6.5.-;4.2.1.24;3.4.22.1;2.7.11.23;3.2.1.31;2.7.1.11;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;2.7.10.1;3.4.24.35;2.7.1.153;2.7.1.137;3.6.1.-;3.1.3.48;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.1.40;2.7.11.21;3.5.4.5;1.13.11.20;3.6.5.2;3.4.25.1;2.7.11.39;2.3.1.-;3.6.4.6;2.7.1.1;2.7.1.-;2.7.11.31;3.1.1.47;3.6.4.13;2.3.2.26;5.4.2.2;5.4.2.7;2.3.1.48;2.3.2.27;3.1.6.14;4.1.1.32;2.7.1.35;2.7.11.38;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;3.6.-.-;2.3.2.5;5.4.2.11;5.4.2.4;3.1.26.-;2.7.11.34;2.4.1.1;2.7.1.154;2.7.11.8;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-;2.7.1.150", "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0042307 positive regulation of protein import into nucleus;GO:0030316 osteoclast differentiation;GO:0071493 cellular response to UV-B;GO:0090400 stress-induced premature senescence", "synthesized_glycan_count": 0, "hit_score": 8.6, "record_id": "P47811-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62225-1", "uniprot_id": "CISH_MOUSE", "mass": 28537.0, "length": 257, "protein_name": "Cytokine-inducible SH2-containing protein", "gene_name": "Cish", "organism": "Mouse", "refseq_name": "cytokine-inducible SH2-containing protein isoform 2", "refseq_ac": "NP_001304283", "gene_names_uniprotkb": "Cish; Cis", "gene_names_refseq": "CIS-1; CIS1; Cish; Cis; F17; F23; SOCS", "protein_names_uniprotkb": "Cytokine-inducible SH2-containing protein; CIS-1; CIS; SOCS; Suppressor of cytokine signaling", "protein_names_refseq": "cytokine-inducible SH2 protein; cytokine-inducible SH2-containing protein isoform 2; suppressor of cytokine signaling", "tax_id": 10090, "disease": "malaria (Disease Ontology:DOID:12365); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (mmu:12700); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;28038963;36083102;37628937;37892192;7796808;9129017", "class_list": "", "function": "Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB)., [RefSeq, PubMed]; Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)., [UniProtKB, PubMed]; The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH) in the Regulation of Basal and Cytokine-Mediated Myelopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC70", "ec_number_list": "", "go_molecular_function": "GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination;GO:0019221 cytokine-mediated signaling pathway;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62225-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49452-1", "uniprot_id": "CENPC_MOUSE", "mass": 102154.0, "length": 906, "protein_name": "Centromere protein C", "gene_name": "Cenpc", "organism": "Mouse", "refseq_name": "centromere protein C isoform 1", "refseq_ac": "NP_001332831", "gene_names_uniprotkb": "Cenpc; Cenpc1", "gene_names_refseq": "CENP-C; Cenpc1; Cenpc", "protein_names_uniprotkb": "Centromere protein C; CENP-C 1; CENP-C; Centromere autoantigen C; Centromere protein C 1", "protein_names_refseq": "centromere autoantigen C1; centromere protein C isoform 1", "tax_id": 10090, "disease": "CREST syndrome (Disease Ontology:DOID:0060218); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:12617); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "21183079;25428506;25533956;30084848;30779550;31219806;7959789", "class_list": "", "function": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions., [UniProtKB, UniProtKB]; This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EK81", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0019237 centromeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0000776 kinetochore;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051382 kinetochore assembly;GO:0051455 spindle attachment to meiosis I kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49452-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKC6-1", "uniprot_id": "CEND_MOUSE", "mass": 14987.0, "length": 149, "protein_name": "Cell cycle exit and neuronal differentiation protein 1", "gene_name": "Cend1", "organism": "Mouse", "refseq_name": "cell cycle exit and neuronal differentiation protein 1", "refseq_ac": "NP_067291", "gene_names_uniprotkb": "Cend1; Bm88", "gene_names_refseq": "1500001H12Rik; BM88; Cend1", "protein_names_uniprotkb": "Cell cycle exit and neuronal differentiation protein 1; BM88 antigen", "protein_names_refseq": "BM88 antigen; cell cycle exit and neuronal differentiation protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57754)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11311134;16949349;17971443;18499894;21183079;23658157;35732922", "class_list": "", "function": "BM88 is widely expressed in the embryonic CNS and PNS, in both nestin-positive neuroepithelial cells and post-mitotic betaIII-tubulin positive neurons., [RefSeq, PubMed]; BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels, [RefSeq, PubMed]; CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease., [RefSeq, PubMed]; Involved in neuronal differentiation., [UniProtKB, PubMed]; Results implicate BM88 in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBA0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0031982 vesicle", "go_biological_process": "GO:0021686 cerebellar granular layer maturation;GO:0021933 radial glia guided migration of cerebellar granule cell;GO:0021941 negative regulation of cerebellar granule cell precursor proliferation;GO:0007628 adult walking behavior;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JKC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08967-1", "uniprot_id": "CYH3_MOUSE", "mass": 46280.0, "length": 399, "protein_name": "Cytohesin-3", "gene_name": "Cyth3", "organism": "Mouse", "refseq_name": "cytohesin-3 isoform 1", "refseq_ac": "NP_035312", "gene_names_uniprotkb": "Cyth3; Grp1; Pscd3", "gene_names_refseq": "ARNO3; CLM3; Cyth3; Grp1; Pscd3", "protein_names_uniprotkb": "Cytohesin-3; ARF nucleotide-binding site opener 3; CLM3; General receptor of phosphoinositides 1; Grp1; PH, SEC7 and coiled-coil domain-containing protein 3; Protein ARNO3; SEC7 homolog C; mSec7-3", "protein_names_refseq": "ARF nucleotide-binding site opener 3; PH, SEC7 and coiled-coil domain-containing protein 3; SEC7 homolog C; cytohesin-3 isoform 1; general receptor of phosphoinositides 1; mSec7-3; pleckstrin homology, Sec7 and coiled-coil domains 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19159); (R-MMU-6811438)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10605025;10828067;10983984;10983985;15359279;18042453;20080746;21750661;31601460;33026967;9072969;9744817", "class_list": "", "function": "Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (PubMed:18042453). Plays a role in the epithelial polarization (PubMed:20080746)., [UniProtKB, PubMed, PubMed]; Structural organization and dynamics of Grp1 and cytohesin-2 in solution and on membranes has been described., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI93", "ec_number_list": "", "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0016192 vesicle-mediated transport;GO:0090162 establishment of epithelial cell polarity;GO:0048193 Golgi vesicle transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08967-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC22-1", "uniprot_id": "DCAF6_MOUSE", "mass": 97588.0, "length": 876, "protein_name": "DDB1- and CUL4-associated factor 6", "gene_name": "Dcaf6", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 6", "refseq_ac": "NP_083035", "gene_names_uniprotkb": "Dcaf6; Iqwd1", "gene_names_refseq": "1200006M05Rik; Dcaf6; Iqwd1; PC326", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; NRIP; Nuclear receptor interaction protein", "protein_names_refseq": "DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; NRIP; nuclear receptor interaction protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74106); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;29608040;33773096;39927985;40885482", "class_list": "", "function": "Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis., [RefSeq, PubMed]; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB]; We demonstrated that deprivation of NRIP decreases myogenin expression at NMJ, possibly leading to abnormal NMJ formation, denervation of acetylcholine receptor, and subsequent loss of spinal motor neuron., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK50", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DC22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923B1-1", "uniprot_id": "DBR1_MOUSE", "mass": 62289.0, "length": 550, "protein_name": "Lariat debranching enzyme", "gene_name": "Dbr1", "organism": "Mouse", "refseq_name": "lariat debranching enzyme isoform 1", "refseq_ac": "NP_113580", "gene_names_uniprotkb": "Dbr1", "gene_names_refseq": "Dbr1", "protein_names_uniprotkb": "Lariat debranching enzyme; 3.1.4.-", "protein_names_refseq": "debranching enzyme homolog 1; lariat debranching enzyme isoform 1; lariat debranching enzyme", "tax_id": 10090, "disease": "brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:83703)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11355701;19144319;21183079;21750661;28135057;28528544", "class_list": "", "function": "Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:11355701). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1T9;Q8C7J7;Q99MT1", "ec_number_list": "", "go_molecular_function": "GO:0008419 RNA lariat debranching enzyme activity;GO:0046872 metal ion binding;GO:0016788 hydrolase activity, acting on ester bonds;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0050821 protein stabilization;GO:0000398 mRNA splicing, via spliceosome;GO:0000292 RNA fragment catabolic process;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q923B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0PHV7-1", "uniprot_id": "DACT3_MOUSE", "mass": 63287.0, "length": 610, "protein_name": "Dapper homolog 3", "gene_name": "Dact3", "organism": "Mouse", "refseq_name": "dapper homolog 3", "refseq_ac": "NP_001075124", "gene_names_uniprotkb": "Dact3", "gene_names_refseq": "Dact3; EG666671; naa-3", "protein_names_uniprotkb": "Dapper homolog 3; Dapper antagonist of catenin 3", "protein_names_refseq": "dact 3; dapper antagonist of catenin 3; dapper homolog 3, antagonist of beta-catenin; dapper homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:629378)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16881060;20170752;21183079;21718540;23580654;24129315;33054518", "class_list": "", "function": "Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3., [RefSeq, PubMed]; Conserved role for Dact3 protein in kinase-regulated biochemistry involving Vangl and Dvl. Publication Status: Online-Only, [RefSeq, PubMed]; Dact3 may contribute to early tooth formation by modulation of Wnt signaling pathways in the mesenchyme, including preodontoblasts, [RefSeq, PubMed]; Dact3, not previously described in any organism, is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, and in the embryonic CNS, [RefSeq, PubMed]; Dapper3 antagonizes the fibrotic actions of Wnt signaling in kidney., [RefSeq, PubMed]; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0051018 protein kinase A binding;GO:0070097 delta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030308 negative regulation of cell growth;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0010719 negative regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q0PHV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZJ7-1", "uniprot_id": "DCNL2_MOUSE", "mass": 30068.0, "length": 259, "protein_name": "DCN1-like protein 2", "gene_name": "Dcun1d2", "organism": "Mouse", "refseq_name": "DCN1-like protein 2 isoform a", "refseq_ac": "NP_001019675", "gene_names_uniprotkb": "Dcun1d2; Dcun1l2; SCCRO2", "gene_names_refseq": "DCNL2; Dcun1d2; mFLJ10704", "protein_names_uniprotkb": "DCN1-like protein 2; DCNL2; DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2; Squamous cell carcinoma-related oncogene 2", "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 2; DCN1-like protein 2 isoform a; DCN1-like protein 2; DCUN1 domain-containing protein 2; defective in cullin neddylation protein 1-like protein 2; squamous cell carcinoma-related oncogene 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:102323); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;21750661;26792857", "class_list": "", "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1U0;Q7TMX3", "ec_number_list": "", "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation;GO:2000434 regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BZJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4J0-1", "uniprot_id": "DCR1C_MOUSE", "mass": 78834.0, "length": 705, "protein_name": "Protein artemis", "gene_name": "Dclre1c", "organism": "Mouse", "refseq_name": "protein artemis isoform 3", "refseq_ac": "NP_001103684", "gene_names_uniprotkb": "Dclre1c; Art; Snm1l", "gene_names_refseq": "9930121L06Rik; Art; Dclre1c; Snm1l", "protein_names_uniprotkb": "Protein artemis; 3.1.-.-; DNA cross-link repair 1C protein; SNM1-like protein; mArt", "protein_names_refseq": "DNA cross-link repair 1A, PSO2 homolog; DNA cross-link repair 1C protein; DNA cross-link repair 1C, PSO2 homolog; SNM1-like protein; protein artemis isoform 3; protein artemis", "tax_id": 10090, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency with sensitivity to ionizing radiation (Disease Ontology:DOID:0090012); common variable immunodeficiency (Disease Ontology:DOID:12177); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:227525); (R-MMU-5693571)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12177301;12504013;12615897;15699179;21183079;21750661;25428506;25818648;30084848;31219806;34428180;36210013", "class_list": "", "function": "ATM phosphorylates DNA-PKcs to recruit Artemis and promote end-processing., [RefSeq, PubMed]; Data show that Artemis appears to be required for a subset of nonhomologous DNA end joining reactions that require end processing [Artemis]., [RefSeq, PubMed]; Deficient mice have a phenotype similar to that of DNA-PKcs-deficient mice-including severe combined immunodeficiency associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing radiation sensitivity (artemis), [RefSeq, PubMed]; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein likely exhibits single-strand specific 5'-3' exonuclease activity in isolation, and may acquire endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity may be required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the SNM1 family of nucleases and is involved in V(D)J recombination and DNA repair. This protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Homozygous knockout mice for this gene exhibit severe combined immunodeficiency with sensitivity to ionizing radiation. Mutations in this gene in humans can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJG6;A2AJG7;A2AJG8;Q8BG72;Q8BTT1", "ec_number_list": "4.2.99.18;5.6.2.4;2.3.2.23;3.6.-.-;2.7.11.1;2.3.2.26;3.1.-.-;2.3.2.27;3.1.4.-;6.5.1.1;2.1.1.357;2.3.1.48;2.3.1.-;2.7.7.7;4.2.99.-", "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0000014 single-stranded DNA endodeoxyribonuclease activity;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0002250 adaptive immune response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K4J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KJ8-1", "uniprot_id": "DCTN2_MOUSE", "mass": 44117.0, "length": 402, "protein_name": "Dynactin subunit 2", "gene_name": "Dctn2", "organism": "Mouse", "refseq_name": "dynactin subunit 2 isoform 3", "refseq_ac": "NP_081427", "gene_names_uniprotkb": "Dctn2", "gene_names_refseq": "2310042E05Rik; C130077D06Rik; DCTN-50; Dctn2; GMP23-48K; RBP50; p50", "protein_names_uniprotkb": "Dynactin subunit 2; 50 kDa dynein-associated polypeptide; DCTN-50; Dynactin complex 50 kDa subunit; GMP23-48K; Growth cone membrane protein 23-48K; p50 dynamitin", "protein_names_refseq": "50 kDa dynein-associated polypeptide; dynactin complex 50 kDa subunit; dynactin subunit 2 isoform 3; dynactin subunit 2; growth cone membrane protein 23-48K; p50 dynamitin", "tax_id": 10090, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:69654); (R-MMU-2132295); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-8854518)", "pathway_count": 12, "publication_count": 15, "publication_id_list": "11483508;14983524;15345747;18034455;21183079;22645316;22956769;28315936;28528544;31219806;34428180;36210013;36288343;37507081;9144527", "class_list": "", "function": "Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes., [RefSeq, PubMed]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (PubMed:14983524)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0016020 membrane;GO:0030426 growth cone", "go_biological_process": "GO:0007080 mitotic metaphase chromosome alignment;GO:0032402 melanosome transport;GO:0007052 mitotic spindle organization;GO:0071539 protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99KJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ62-1", "uniprot_id": "DECR_MOUSE", "mass": 36214.0, "length": 335, "protein_name": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial", "gene_name": "Decr1", "organism": "Mouse", "refseq_name": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor", "refseq_ac": "NP_080448", "gene_names_uniprotkb": "Decr1", "gene_names_refseq": "1200012F07Rik; Decr1; Decr; Nadph", "protein_names_uniprotkb": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 1.3.1.124; 2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]", "protein_names_refseq": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 2,4-dienoyl-CoA reductase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:67460); (R-MMU-77288)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19578400;23576753;23806337;30084848;31219806;35820727;36288343;37453647;37507081;39927985", "class_list": "", "function": "Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the Enoyl-CoA delta isomerase 1 (ECI1) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Acts primarily on polyunsaturated fatty acids. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally., [UniProtKB, UniProtKB]; Fasted Decr(-/-) mice displayed increased serum acylcarnitines and unimpaired ketogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCI7", "ec_number_list": "1.3.1.124", "go_molecular_function": "GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:1902494 catalytic complex", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CQ62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAR7-1", "uniprot_id": "DCPS_MOUSE", "mass": 38988.0, "length": 338, "protein_name": "m7GpppX diphosphatase", "gene_name": "Dcps", "organism": "Mouse", "refseq_name": "m7GpppX diphosphatase", "refseq_ac": "NP_081306", "gene_names_uniprotkb": "Dcps; Dcs1; Hint5", "gene_names_refseq": "1700001E16Rik; DCS-1; Dcps; HINT-5", "protein_names_uniprotkb": "m7GpppX diphosphatase; 3.6.1.59; DCS-1; Decapping scavenger enzyme; HINT-5; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; Scavenger mRNA-decapping enzyme DcpS", "protein_names_refseq": "decapping scavenger enzyme; hint-related 7meGMP-directed hydrolase; histidine triad nucleotide-binding protein 5; histidine triad protein member 5; m7GpppX diphosphatase; mRNA decapping enzyme; scavenger mRNA-decapping enzyme DcpS", "tax_id": 10090, "disease": "", "pathway": " (mmu:69305); (R-MMU-429958)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16001405;17242355;21183079;21750661;22872234;23386199;23806337;30858142;31219806;34203471;34428180", "class_list": "", "function": "Amino acid sequence and xray crystallograpy structure given, [RefSeq, PubMed]; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death., [UniProtKB]; NATTD as a regulator of DcpS transcription through epigenetic mechanisms, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5I7", "ec_number_list": "3.6.1.59;3.6.1.52;3.6.1.62;3.6.1.10;3.6.1.61", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0045292 mRNA cis splicing, via spliceosome;GO:0110156 mRNA methylguanosine-cap decapping", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9DAR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08553-1", "uniprot_id": "DPYL2_MOUSE", "mass": 62278.0, "length": 572, "protein_name": "Dihydropyrimidinase-related protein 2", "gene_name": "Dpysl2", "organism": "Mouse", "refseq_name": "dihydropyrimidinase-related protein 2 isoform 2", "refseq_ac": "NP_034085", "gene_names_uniprotkb": "Dpysl2; Crmp2; Ulip2", "gene_names_refseq": "Crmp2; DRP2; Dpysl2; Musunc33; TOAD-64; Ulip2", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 2; DRP-2; ULIP-2; Unc-33-like phosphoprotein 2", "protein_names_refseq": "DRP-2; ULIP-2; collapsin response mediator protein 2; dihydropyrimidinase-related protein 2 isoform 2; dihydropyrimidinase-related protein 2; unc-33-like phosphoprotein 2", "tax_id": 10090, "disease": "hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:12934); (R-MMU-399956); (R-MMU-437239)", "pathway_count": 3, "publication_count": 63, "publication_id_list": "10.1101/2023.09.13.557529;10956643;15345747;15466885;15648052;15676027;16230462;17683481;18034455;19131326;21183079;21750661;21943307;22057101;22279220;22517741;22544872;22645316;23022559;23470087;23806337;24129315;24227739;25073924;25153642;26250894;26495903;26740625;28524835;28528544;28638064;28657654;29434807;29758318;30031227;30046097;30194029;30375127;31453382;31599954;31771416;32019603;32049584;32848054;32848595;32860158;33300544;33318403;34428180;34678516;35589915;35820727;35822049;36288343;36293516;37507081;37669863;37828378;40021952;40684658;40885482;9375656;9652388", "class_list": "", "function": "Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Synapse-Enriched m[6]A-Modified Malat1 Interacts with the Novel m[6]A Reader, DPYSL2, and Is Required for Fear-Extinction Memory., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5D0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0014049 positive regulation of glutamate secretion;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 8.1, "record_id": "O08553-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35098-1", "uniprot_id": "DPYL4_MOUSE", "mass": 61962.0, "length": 572, "protein_name": "Dihydropyrimidinase-related protein 4", "gene_name": "Dpysl4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dpysl4; Crmp3; Ulip4", "gene_names_refseq": "", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 4; CRMP-3; Collapsin response mediator protein 3; DRP-4; ULIP-4; UNC33-like phosphoprotein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-399956)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10956643;14685275;18034455;21183079;21750661;40684658;9375656;9652388", "class_list": "", "function": "Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08886;Q3UL94", "ec_number_list": "", "go_molecular_function": "GO:0051219 phosphoprotein binding;GO:0031005 filamin binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016787 hydrolase activity;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70133-1", "uniprot_id": "DHX9_MOUSE", "mass": 149475.0, "length": 1380, "protein_name": "ATP-dependent RNA helicase A", "gene_name": "Dhx9", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase A isoform 2", "refseq_ac": "NP_031868", "gene_names_uniprotkb": "Dhx9; Ddx9", "gene_names_refseq": "Ddx9; Dhx9; HEL-5; NDHII; RHA; mHEL-5", "protein_names_uniprotkb": "ATP-dependent RNA helicase A; 3.6.4.13; DEAH box protein 9; NDH II; Nuclear DNA helicase II; RHA; RNA helicase A; mHEL-5", "protein_names_refseq": "ATP-dependent RNA helicase A isoform 2; ATP-dependent RNA helicase A; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 9; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 9; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box protein 9; leukophysin; nuclear DNA helicase II", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 75 (Disease Ontology:DOID:0061048); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:13211); (R-MMU-1810476); (R-MMU-3134963); (R-MMU-72163); (R-MMU-9770562); (R-MMU-9833482)", "pathway_count": 6, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;10413677;14691545;17242355;17251188;17303075;18068128;18630941;19229320;21183079;21750661;22767893;23806337;24129315;28011936;28355180;28636595;31219806;34428180;34887587;37369308;37467750;37507081;37828378;38247850;38594251;39627609;9480750", "class_list": "", "function": "DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease., [RefSeq, PubMed]; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA- and RNA-based G-quadruplexes. Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA. Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A. Plays a role in DNA replication at origins of replication and cell cycle progression. Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1. Binds to the CDKN2A promoter. Plays several roles in post-transcriptional regulation of gene expression. In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (By similarity). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (PubMed:22767893). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs. Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation. Also plays a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35931;O54703;Q5FWY1;Q6R5F7;Q9CSA2", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.1.3.16;3.1.3.53;3.6.1.15;3.1.4.-;2.7.10.2;2.7.11.1;5.6.2.-;3.4.19.12;7.2.2.-;7.6.2.16;2.7.7.19;3.4.21.53;2.7.7.7;2.7.7.49;2.7.7.52;2.7.4.3;2.7.1.78;5.2.1.8;3.1.27.-", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0043138 3'-5' DNA helicase activity;GO:0001069 regulatory region RNA binding;GO:0045142 triplex DNA binding;GO:0061676 importin-alpha family protein binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:1903608 protein localization to cytoplasmic stress granule;GO:0032741 positive regulation of interleukin-18 production;GO:0039695 DNA-templated viral transcription", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "O70133-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51141-1", "uniprot_id": "DVL1_MOUSE", "mass": 75359.0, "length": 695, "protein_name": "Segment polarity protein dishevelled homolog DVL-1", "gene_name": "Dvl1", "organism": "Mouse", "refseq_name": "segment polarity protein dishevelled homolog DVL-1 isoform 1", "refseq_ac": "NP_034221", "gene_names_uniprotkb": "Dvl1; Dvl", "gene_names_refseq": "Dvl1; Dvl; mKIAA4029", "protein_names_uniprotkb": "Segment polarity protein dishevelled homolog DVL-1; DSH homolog 1; Dishevelled-1", "protein_names_refseq": "DSH homolog 1; dishevelled, dsh homolog 1; dishevelled-1; segment polarity protein dishevelled homolog DVL-1 isoform 1; segment polarity protein dishevelled homolog DVL-1", "tax_id": 10090, "disease": "autosomal dominant Robinow syndrome 2 (Disease Ontology:DOID:0060765); DiGeorge syndrome (Disease Ontology:DOID:11198); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:13542); (R-MMU-201688); (R-MMU-4086400); (R-MMU-4641258); (R-MMU-4641262); (R-MMU-5663220)", "pathway_count": 6, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;11101902;12165471;12941796;14636582;15353129;15454084;15456783;16604061;16965538;19637179;20227366;21189423;22517741;27214281;32782141;35822049;40885482;7958461;9132266;9298901", "class_list": "", "function": "Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2D3;Q60868", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P51141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56387-1", "uniprot_id": "DYLT3_MOUSE", "mass": 12958.0, "length": 116, "protein_name": "Dynein light chain Tctex-type 3", "gene_name": "Dynlt3", "organism": "Mouse", "refseq_name": "dynein light chain Tctex-type 3", "refseq_ac": "NP_080251", "gene_names_uniprotkb": "Dynlt3; Tcte1l", "gene_names_refseq": "2310075M16Rik; Dynlt3; Tcte1l", "protein_names_uniprotkb": "Dynein light chain Tctex-type 3; Protein 91/23; T-complex-associated testis-expressed 1-like", "protein_names_refseq": "dynein light chain Tctex-type 3; protein 91/23", "tax_id": 10090, "disease": "", "pathway": " (mmu:67117)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16800626;17289665;21693773;33772156", "class_list": "", "function": "A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Publication Status: Online-Only, [RefSeq, PubMed]; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis., [UniProtKB]; Data suggest that DNYLT3 is required for chromosome alignment and homologous segregation during mouse oocyte meiosis., [RefSeq, PubMed]; Subpopulation of dynein, containing the DYNLT3 light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000776 kinetochore;GO:0005868 cytoplasmic dynein complex;GO:0061673 mitotic spindle astral microtubule", "go_biological_process": "GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56387-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63168-1", "uniprot_id": "DYL1_MOUSE", "mass": 10366.0, "length": 89, "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "Dynll1", "organism": "Mouse", "refseq_name": "dynein light chain 1, cytoplasmic", "refseq_ac": "NP_062656", "gene_names_uniprotkb": "Dynll1; Dlc1; Dncl1; Dnclc1", "gene_names_refseq": "Dlc8; Dnclc1; Dynll1; Pin", "protein_names_uniprotkb": "Dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; PIN; Protein inhibitor of neuronal nitric oxide synthase; mPIN", "protein_names_refseq": "8 kDa dynein light chain; 8kD LC; 8kDa LC; dynein light chain 1, cytoplasmic; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; mPIN; protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase", "tax_id": 10090, "disease": "cardiac arrest (Disease Ontology:DOID:0060319); hypertension (Disease Ontology:DOID:10763); impotence (Disease Ontology:DOID:1875); middle cerebral artery infarction (Disease Ontology:DOID:3525); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:56455); (R-MMU-111446); (R-MMU-141430); (R-MMU-141444); (R-MMU-1632852); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5620924); (R-MMU-5663220); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8854518); (R-MMU-9646399); (R-MMU-9648025)", "pathway_count": 24, "publication_count": 9, "publication_id_list": "21478148;22956769;23806337;28135057;33300544;33649389;34428180;34543116;36210013", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (By similarity). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (By similarity). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (By similarity). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (By similarity). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (By similarity). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (By similarity). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-kappaB Pathway Activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q15701;Q3UGE7", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051881 regulation of mitochondrial membrane potential;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P63168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61483-1", "uniprot_id": "DLL1_MOUSE", "mass": 78449.0, "length": 722, "protein_name": "Delta-like protein 1", "gene_name": "Dll1", "organism": "Mouse", "refseq_name": "delta-like protein 1 precursor", "refseq_ac": "NP_031891", "gene_names_uniprotkb": "Dll1", "gene_names_refseq": "Delta1; Dll1", "protein_names_uniprotkb": "Delta-like protein 1; Delta1; Drosophila Delta homolog 1", "protein_names_refseq": "delta like-1; delta-like 1; delta-like protein 1 precursor; delta-like protein 1; drosophila Delta homolog 1", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:13388); (R-MMU-9013507)", "pathway_count": 2, "publication_count": 37, "publication_id_list": "10.1101/2023.09.13.557529;10958687;12794186;15146182;15788413;15908431;16495313;17003037;17194759;17960184;18676613;18997111;19144989;19217325;19389377;19562077;19723503;20081190;21238454;21572390;21750661;21915337;21985982;22015720;22096075;22282195;22529374;22940113;23688253;23695674;23699523;23806616;24449764;24715457;25220152;26114479;7671806", "class_list": "", "function": "Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:10958687, PubMed:21985982). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerization; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (PubMed:10958687, PubMed:18676613). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:16495313, PubMed:17194759, PubMed:17960184, PubMed:18997111, PubMed:19144989, PubMed:19389377, PubMed:19562077, PubMed:20081190, PubMed:21238454, PubMed:21572390, PubMed:22096075, PubMed:22282195, PubMed:22529374, PubMed:22940113, PubMed:23688253, PubMed:23695674, PubMed:23699523, PubMed:23806616, PubMed:25220152, PubMed:26114479, PubMed:7671806). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner (PubMed:18997111, PubMed:7671806). During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries (PubMed:23699523). During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway (PubMed:23688253). At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway (PubMed:19389377, PubMed:26114479). Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis (PubMed:20081190). Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell (PubMed:23695674). Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B cells (PubMed:15146182, PubMed:19217325). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (By similarity). Upon MMP14 cleavage, negatively regulates Notch signaling in haematopoietic progenitor cells to specifically maintain normal B-cell development in bone marrow (PubMed:21572390). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation (PubMed:17194759). Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression (PubMed:22940113). During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression (PubMed:25220152). Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium (PubMed:22529374). Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels (PubMed:22096075). During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression (PubMed:19144989). Controls sprouting angiogenesis and subsequent vertical branch formation through regulation on tip cell differentiation (PubMed:22282195). Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine (PubMed:21238454, PubMed:21915337). Plays a role during inner ear development; negatively regulates auditory hair cell differentiation (PubMed:16495313). Plays a role during nephron development through Notch signaling pathway (PubMed:23806616). Regulates growth, blood pressure and energy homeostasis (PubMed:19562077)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFV7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0030957 Tat protein binding;GO:0097110 scaffold protein binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0021688 cerebellar molecular layer formation;GO:0021693 cerebellar Purkinje cell layer structural organization;GO:0032693 negative regulation of interleukin-10 production;GO:0045605 negative regulation of epidermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q61483-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6WQJ1-1", "uniprot_id": "DGLA_MOUSE", "mass": 115375.0, "length": 1044, "protein_name": "Diacylglycerol lipase-alpha", "gene_name": "Dagla", "organism": "Mouse", "refseq_name": "diacylglycerol lipase-alpha", "refseq_ac": "NP_932782", "gene_names_uniprotkb": "Dagla; Kiaa0659; Nsddr", "gene_names_refseq": "Dagla; Nsddr", "protein_names_uniprotkb": "Diacylglycerol lipase-alpha; 3.1.1.116; DAGL-alpha; DGL-alpha; Neural stem cell-derived dendrite regulator; Sn1-specific diacylglycerol lipase alpha", "protein_names_refseq": "DAGL-alpha; DGL-alpha; diacylglycerol lipase-alpha; neural stem cell-derived dendrite regulator; sn1-specific diacylglycerol lipase alpha", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:269060); (R-MMU-426048)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14610053;16452087;16723519;17584991;20147530;20159446;21183079;21750661;23103940;23502535;25428506;25466252;26668358;26779719;31219806;33300544;34428180;38265773", "class_list": "", "function": "Astrocytic Dagla Deletion Decreases Hedonic Feeding in Female Mice., [RefSeq, PubMed]; Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid (eCB), 2-arachidonoylglycerol (2-AG) (PubMed:17584991, PubMed:23103940). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:17584991). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS) (PubMed:20147530, PubMed:20159446, PubMed:25466252, PubMed:26668358, PubMed:26779719). Controls the activity of 2-AG as a retrograde messenger at neuronal synapses (PubMed:20147530, PubMed:20159446, PubMed:26668358). Supports axonal growth during development and adult neurogenesis (PubMed:20147530). Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors (PubMed:25466252). Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (PubMed:26779719)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8WFL4;Q6ZQ76", "ec_number_list": "3.1.1.32;3.1.1.3;3.1.1.5;3.1.1.116", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0031901 early endosome membrane;GO:0032590 dendrite membrane;GO:0043196 varicosity", "go_biological_process": "GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:0045471 response to ethanol;GO:0046340 diacylglycerol catabolic process;GO:0007405 neuroblast proliferation;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6WQJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RWS6-1", "uniprot_id": "EP300_MOUSE", "mass": 263305.0, "length": 2412, "protein_name": "Histone acetyltransferase p300", "gene_name": "Ep300", "organism": "Mouse", "refseq_name": "histone acetyltransferase p300", "refseq_ac": "NP_808489", "gene_names_uniprotkb": "Ep300; P300", "gene_names_refseq": "A430090G16; A730011L11; Ep300; KAT3B; p300 HAT; p300", "protein_names_uniprotkb": "Histone acetyltransferase p300; 2.3.1.-; 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Protein 2-hydroxyisobutyryltransferase p300; Protein isonicotinyltransferase p300; Protein lactyltransferas p300; Protein propionyltransferase p300; p300 HAT", "protein_names_refseq": "E1A-associated protein p300; histone acetyltransferase p300; histone butyryltransferase p300; histone crotonyltransferase p300; protein 2-hydroxyisobutyryltransferase p300; protein isonicotinyltransferase p300; protein lactyltransferas p300; protein propionyltransferase p300", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cardiomyopathy (Disease Ontology:DOID:0050700); cardiac arrest (Disease Ontology:DOID:0060319); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); transient cerebral ischemia (Disease Ontology:DOID:224); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:328572); (R-MMU-1234158); (R-MMU-201722); (R-MMU-2122947); (R-MMU-3134973); (R-MMU-3371568); (R-MMU-3899300); (R-MMU-5250924); (R-MMU-5621575); (R-MMU-5689901); (R-MMU-6804758); (R-MMU-6804760); (R-MMU-6811555); (R-MMU-8866907); (R-MMU-8936459); (R-MMU-8939243); (R-MMU-8941856); (R-MMU-8941858); (R-MMU-8951936); (R-MMU-9018519); (R-MMU-9029569); (R-MMU-933541); (R-MMU-9617629); (R-MMU-9701898); (R-MMU-9759194); (R-MMU-9856649)", "pathway_count": 26, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;10593900;10722728;11115394;12709428;14645221;15601857;16917507;18486321;19324970;20810990;20940255;20955178;21183079;21750661;23806337;24216764;25200183;25428506;27105113;28576496;28883095;30059200;30084848;30546087;31219806;34428180;35075301;35409338;36852467;37828378;40885482;40997131;9512516", "class_list": "", "function": "Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (By similarity). Acetylates all four core histones in nucleosomes (By similarity). Histone acetylation gives an epigenetic tag for transcriptional activation (By similarity). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (By similarity). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (By similarity). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (By similarity). In response to DNA damage, catalyzes acetylation of histone H1 at 'Lys-75' (H1K75ac) following histone H1 deamidation by CTPS1, increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins (By similarity). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRDM16, PRMT1, SIRT2, STAT3, ZNF76 or GLUL (PubMed:28576496, PubMed:28883095, PubMed:35075301). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (By similarity). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (By similarity). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (By similarity). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (By similarity). Acetylates HDAC1 leading to its inactivation and modulation of transcription (By similarity). Acetylates 'Lys-247' of EGR2 (PubMed:28576496). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (By similarity). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium (By similarity). Promotes cardiac myocyte enlargement (By similarity). Can also mediate transcriptional repression (By similarity). Acetylates FOXO1 and enhances its transcriptional activity (By similarity). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (By similarity). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (By similarity). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (By similarity). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:14645221, PubMed:9512516). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates MEF2D (By similarity). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (PubMed:25200183). Acetylates PCK1 and promotes PCK1 anaplerotic activity (By similarity). Acetylates RXRA and RXRG (By similarity). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (By similarity). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (By similarity). Acetylates RICTOR, leading to activation of the mTORC2 complex (By similarity). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:18486321, PubMed:24216764). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA, propanoyl-CoA (propionyl-CoA) or isonicotinyl-CoA, and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation, propionylation or isonicotinylation, respectively (PubMed:27105113). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (By similarity). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:27105113). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (By similarity). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes. Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 0, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 20, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "E9PYJ8", "ec_number_list": "2.3.2.26;2.3.1.48;2.3.1.-;2.1.1.364;3.1.13.1;3.6.4.13;5.6.2.6;3.6.4.-;3.5.1.-;3.5.1.98;2.7.7.6;2.3.2.27;2.3.2.-;1.14.11.68;2.7.11.2;2.7.11.-;3.4.21.79;3.1.13.-;2.7.7.48;1.14.19.1;2.7.11.22;2.7.11.23;6.2.1.3;6.2.1.24;6.2.1.15;2.1.1.-;3.6.4.10;2.3.1.21;6.2.1.1;6.2.1.17;2.1.1.356;2.3.1.15;3.4.19.-;2.7.11.1;2.3.1.199;2.1.1.320;2.3.1.51;2.3.1.286;2.3.1.259;2.3.1.20;2.3.1.76;2.3.1.57;2.1.1.319;2.3.1.80;4.2.1.-;2.7.10.2", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0061733 protein-lysine-acetyltransferase activity;GO:0061920 protein propionyltransferase activity;GO:0097157 pre-mRNA intronic binding;GO:0140065 peptide butyryltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1904263 positive regulation of TORC1 signaling;GO:0006475 internal protein amino acid acetylation;GO:0061921 peptidyl-lysine propionylation;GO:0090043 regulation of tubulin deacetylation", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "B2RWS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0G8-1", "uniprot_id": "ESRP2_MOUSE", "mass": 77361.0, "length": 717, "protein_name": "Epithelial splicing regulatory protein 2", "gene_name": "Esrp2", "organism": "Mouse", "refseq_name": "epithelial splicing regulatory protein 2", "refseq_ac": "NP_789808", "gene_names_uniprotkb": "Esrp2; Rbm35b", "gene_names_refseq": "9530027K23Rik; Esrp2; Rbm35b", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 2; RNA-binding motif protein 35B; RNA-binding protein 35B", "protein_names_refseq": "RNA binding motif protein 35b; RNA-binding motif protein 35B; RNA-binding protein 35B; epithelial splicing regulatory protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77411)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14681479;17242355;19285943;21183079;21750661;22037216;30084848;31599954;34428180;40997131", "class_list": "", "function": "DeltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta-induced EMT and the progression of breast cancers, [RefSeq, PubMed]; Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 splicing., [RefSeq, PubMed]; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEK2", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0050679 positive regulation of epithelial cell proliferation;GO:0060445 branching involved in salivary gland morphogenesis;GO:0060441 epithelial tube branching involved in lung morphogenesis;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K0G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61539-1", "uniprot_id": "ERR2_MOUSE", "mass": 48328.0, "length": 433, "protein_name": "Steroid hormone receptor ERR2", "gene_name": "Esrrb", "organism": "Mouse", "refseq_name": "steroid hormone receptor ERR2 isoform 2", "refseq_ac": "NP_001152972", "gene_names_uniprotkb": "Esrrb; Err-2; Err2; Nr3b2", "gene_names_refseq": "Err2; Errb; Esrrb; Estrrb; Nr3b2", "protein_names_uniprotkb": "Steroid hormone receptor ERR2; ERR-beta; Estrogen receptor-like 2; Estrogen-related receptor beta; Nuclear receptor subfamily 3 group B member 2", "protein_names_refseq": "ERR-beta; estrogen receptor related 2; estrogen receptor-like 2; nuclear receptor subfamily 3 group B member 2; steroid hormone receptor ERR2 isoform 2; steroid hormone receptor ERR2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 35 (Disease Ontology:DOID:0110493); dilated cardiomyopathy (Disease Ontology:DOID:12930); azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:26380); (R-MMU-383280)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "17765677;18472334;18662995;18957414;20534447;21750661;23019124;23040477;23040478;23169531;23508100;26206133;26523946;27601327;27723719;31492838;34397088;39361745;8652414;9285590", "class_list": "", "function": "Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity (PubMed:18662995, PubMed:18957414, PubMed:20534447, PubMed:23019124, PubMed:23169531, PubMed:23508100, PubMed:26206133, PubMed:27601327, PubMed:27723719). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways (PubMed:18957414, PubMed:20534447, PubMed:23019124, PubMed:23040477, PubMed:23040478, PubMed:23169531, PubMed:26206133, PubMed:34397088). Involved in morula development (2-16 cells embryos) by acting as a regulator at the 8-cell stage (PubMed:39361745). Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells (PubMed:26206133). Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (PubMed:20534447). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:18662995, PubMed:18957414, PubMed:23508100). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase (PubMed:27723719). Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation (PubMed:18662995, PubMed:23019124, PubMed:23169531, PubMed:26206133). This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program (PubMed:23169531). Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (PubMed:17765677, PubMed:9285590)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTQ7;O09067;O09146;Q8C7A6", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000793 condensed chromosome", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14753-1", "uniprot_id": "EPOR_MOUSE", "mass": 55194.0, "length": 507, "protein_name": "Erythropoietin receptor", "gene_name": "Epor", "organism": "Mouse", "refseq_name": "erythropoietin receptor isoform 1 precursor", "refseq_ac": "NP_034279", "gene_names_uniprotkb": "Epor", "gene_names_refseq": "Epor", "protein_names_uniprotkb": "Erythropoietin receptor; EPO-R", "protein_names_refseq": "EPO-R; erythropoietin receptor isoform 1 precursor", "tax_id": 10090, "disease": "familial erythrocytosis 1 (Disease Ontology:DOID:0060652); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); retinopathy of prematurity (Disease Ontology:DOID:13025); hepatic encephalopathy (Disease Ontology:DOID:13413); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); high grade glioma (Disease Ontology:DOID:3070); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); polycythemia (Disease Ontology:DOID:8432); polycythemia vera (Disease Ontology:DOID:8997); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:13857); (R-MMU-9006335); (R-MMU-9027276); (R-MMU-9027284)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10660611;11290583;11443118;12444928;12859190;12930840;1656233;1849897;21183685;2162479;21750661;2175360;2539263;35820727;7559499;7889566;8068943;8341708;8382775;8617735;8639815;8657137;8665851;9573010;9774439", "class_list": "", "function": "Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:2539263, PubMed:8341708, PubMed:8382775, PubMed:8617735). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (PubMed:2539263, PubMed:8382775, PubMed:8617735). In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase (PubMed:9573010)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 1, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 1, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 1, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 1, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 112, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63852", "ec_number_list": "", "go_molecular_function": "GO:0004900 erythropoietin receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016607 nuclear speck;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P14753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42567-1", "uniprot_id": "EPS15_MOUSE", "mass": 98471.0, "length": 897, "protein_name": "Epidermal growth factor receptor substrate 15", "gene_name": "Eps15", "organism": "Mouse", "refseq_name": "epidermal growth factor receptor substrate 15 isoform B", "refseq_ac": "NP_001153436", "gene_names_uniprotkb": "Eps15", "gene_names_refseq": "2410112D09Rik; Eps15", "protein_names_uniprotkb": "Epidermal growth factor receptor substrate 15; Protein AF-1p; Protein Eps15", "protein_names_refseq": "epidermal growth factor pathway substrate 15; epidermal growth factor receptor substrate 15 isoform B; epidermal growth factor receptor substrate 15; protein AF-1p", "tax_id": 10090, "disease": "", "pathway": " (mmu:13858); (R-MMU-182971); (R-MMU-6807004); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9766229)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "10393179;10471276;10953014;12057195;12616489;16159959;17242355;17626015;19144319;20448150;21183079;21750661;21762413;22648170;25153642;33820972;37828378;39627609;7689153", "class_list": "", "function": "Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2., [UniProtKB, UniProtKB, UniProtKB]; Liquid-like protein interactions catalyse assembly of endocytic vesicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C431", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006897 endocytosis;GO:0042127 regulation of cell population proliferation;GO:0032880 regulation of protein localization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P42567-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60902-1", "uniprot_id": "EP15R_MOUSE", "mass": 99309.0, "length": 907, "protein_name": "Epidermal growth factor receptor substrate 15-like 1", "gene_name": "Eps15l1", "organism": "Mouse", "refseq_name": "epidermal growth factor receptor substrate 15-like 1 isoform b", "refseq_ac": "NP_001116304", "gene_names_uniprotkb": "Eps15l1; Eps15-rs; Eps15R", "gene_names_refseq": "9830147J04Rik; Eps15-rs; Eps15R; Eps15l1", "protein_names_uniprotkb": "Epidermal growth factor receptor substrate 15-like 1; Epidermal growth factor receptor pathway substrate 15-related sequence; Eps15-related protein; Eps15-rs; Eps15R", "protein_names_refseq": "epidermal growth factor receptor pathway substrate 15-related sequence; epidermal growth factor receptor substrate 15-like 1 isoform b; eps15-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13859); (R-MMU-182971); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "15592455;16452087;17114649;17242355;19144319;20448150;21183079;21750661;22648170;26495903;28972287;35820727;7568168;9446614", "class_list": "", "function": "A novel interaction motif in Eps15R, DPFxxLDPF, is shown to bind directly to the clathrin terminal domain in vitro. Interaction between Eps15R and clathrin is required for EphB2-mediated cell repulsion. Erratum:[Traffic. 2025 Apr-Jun;26(4-6):e70012. doi: 10.1111/tra.70012. PMID: 40474590], [RefSeq, PubMed]; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7L9;Q3UIS9;Q8CB60;Q8CB70;Q91WH8", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0030132 clathrin coat of coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0016197 endosomal transport;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q60902-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNS8-1", "uniprot_id": "EPOP_MOUSE", "mass": 38095.0, "length": 369, "protein_name": "Elongin BC and Polycomb repressive complex 2-associated protein", "gene_name": "Epop", "organism": "Mouse", "refseq_name": "elongin BC and Polycomb repressive complex 2-associated protein", "refseq_ac": "NP_780541", "gene_names_uniprotkb": "Epop; E13", "gene_names_refseq": "E130012A19Rik; E13; Epop; esPRC2p48", "protein_names_uniprotkb": "Elongin BC and Polycomb repressive complex 2-associated protein; ES cell-specific PRC2 subunit p48; Embryonic stem cell-specific PRC2 subunit p48; esPRC2p48", "protein_names_refseq": "ES cell-specific PRC2 subunit p48; elongin BC and Polycomb repressive complex 2-associated protein; elongin and polycomb associated protein; embryonic stem cell-specific PRC2 subunit p48; uncharacterized protein C17orf96 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:103551)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21732481;23180766;27462409;27863225;27863226;33311485;33688077;34011527", "class_list": "", "function": "Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity., [RefSeq, PubMed]; PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrated that E130012A19Rik (E13), is a protein-coding gene implicated in regulating the commitment towards the different neuronal subtypes and glia cells., [RefSeq, PubMed]; Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs) (PubMed:27863225, PubMed:27863226). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex (PubMed:27863225, PubMed:27863226). Interaction with USP7 promotes deubiquitination of H2B at promoter sites (PubMed:27863226). Acts as a regulator of neuronal differentiation (PubMed:23180766)., [UniProtKB, PubMed, PubMed, PubMed]; Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations., [RefSeq, PubMed]; These studies identify JARID2, MTF2, and esPRC2p48 as important regulatory subunits of PRC2 in ES cells and reveal critical functions of these subunits., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN79;Q99JK6", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0048663 neuron fate commitment;GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TNS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0S2-1", "uniprot_id": "ERIC5_MOUSE", "mass": 38527.0, "length": 362, "protein_name": "Glutamate-rich protein 5", "gene_name": "Erich5", "organism": "Mouse", "refseq_name": "glutamate-rich protein 5", "refseq_ac": "NP_775597", "gene_names_uniprotkb": "Erich5", "gene_names_refseq": "Erich5", "protein_names_uniprotkb": "Glutamate-rich protein 5", "protein_names_refseq": "glutamate-rich protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:239368)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS52;Q3UX98", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K0S2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LY2-1", "uniprot_id": "GDPD3_MOUSE", "mass": 38488.0, "length": 330, "protein_name": "Lysophospholipase D GDPD3", "gene_name": "Gdpd3", "organism": "Mouse", "refseq_name": "lysophospholipase D GDPD3", "refseq_ac": "NP_077190", "gene_names_uniprotkb": "Gdpd3; Gde7", "gene_names_refseq": "1110015E22Rik; Gdpd3", "protein_names_uniprotkb": "Lysophospholipase D GDPD3; 3.1.4.-; Glycerophosphodiester phosphodiesterase 7; Glycerophosphodiester phosphodiesterase domain-containing protein 3", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 7; glycerophosphodiester phosphodiesterase domain-containing protein 3; lysophospholipase D GDPD3", "tax_id": 10090, "disease": "", "pathway": " (mmu:68616)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "25528375;26714588;27637550;32943626;34523685;38769197", "class_list": "", "function": "Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid. Erratum:[J Biochem. 2022 Mar 31;171(4):467. doi: 10.1093/jb/mvab152. PMID: 35137094], [RefSeq, PubMed]; GDPD3 Deficiency Alleviates Neuropathic Pain and Reprograms Macrophagic Polarization Through PGE2 and PPARgamma Pathway., [RefSeq, PubMed]; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25528375, PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:25528375). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (PubMed:25528375)., [UniProtKB, PubMed, PubMed]; The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; This study identified Gdpd3 as a candidate genetic marker for memory T cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1C0", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;3.1.1.4;3.1.1.32;3.1.1.3;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;3.1.4.54;3.1.4.-;3.1.4.44;3.1.4.39;3.1.4.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0046475 glycerophospholipid catabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99LY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88273-1", "uniprot_id": "GREM2_MOUSE", "mass": 19334.0, "length": 168, "protein_name": "Gremlin-2", "gene_name": "Grem2", "organism": "Mouse", "refseq_name": "gremlin-2 precursor", "refseq_ac": "NP_035955", "gene_names_uniprotkb": "Grem2; Cktsf1b2; Prdc", "gene_names_refseq": "Grem2; Gremlin2; Prdc", "protein_names_uniprotkb": "Gremlin-2; Cysteine knot superfamily 1, BMP antagonist 2; PRDC; Protein related to DAN and cerberus", "protein_names_refseq": "Gremlin1; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2 homolog, cysteine knot superfamily; gremlin-2 precursor; gremlin-2; protein related to DAN and cerberus", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591)", "pathway": " (mmu:23893); (R-MMU-201451)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15039429;17222801;23063586;23850456;26416033;37880751;38839844;39349059;9639362", "class_list": "", "function": "BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety. Publication Status: Online-Only, [RefSeq, PubMed]; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells., [UniProtKB, PubMed, PubMed, PubMed]; GREM2 inactivation increases trabecular bone mass in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Ovarian PRDC expressed in granulosa cells could be involved in follicular development by antagonizing the actions of theca cell-derived Bone morphogenetic proteins, [RefSeq, PubMed]; The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; We propose that PRDC might serve as a mediator to antagonize BMP-4 signaling by Wnt., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0060300 regulation of cytokine activity;GO:0030514 negative regulation of BMP signaling pathway;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PEM6-1", "uniprot_id": "GRM2B_MOUSE", "mass": 49272.0, "length": 445, "protein_name": "GRAM domain-containing protein 2B", "gene_name": "Gramd2b", "organism": "Mouse", "refseq_name": "GRAM domain-containing protein 2B isoform 1", "refseq_ac": "NP_001347846", "gene_names_uniprotkb": "Gramd2b; Gramd3", "gene_names_refseq": "9030613F08Rik; 9130427A09Rik; Gramd2b; Gramd3; NS3TP2", "protein_names_uniprotkb": "GRAM domain-containing protein 2B; GRAM domain-containing protein 3", "protein_names_refseq": "GRAM domain containing 3; GRAM domain-containing protein 2B isoform 1; GRAM domain-containing protein 2B; GRAM domain-containing protein 3; HCV NS3-transactivated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:107022)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q8C6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005881 cytoplasmic microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PEM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61221-1", "uniprot_id": "HIF1A_MOUSE", "mass": 93516.0, "length": 836, "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "Hif1a", "organism": "Mouse", "refseq_name": "hypoxia-inducible factor 1-alpha isoform 1", "refseq_ac": "NP_001300848", "gene_names_uniprotkb": "Hif1a", "gene_names_refseq": "HIF-1-alpha; HIF1-alpha; HIF1alpha; Hif1a; MOP1; bHLHe78", "protein_names_uniprotkb": "Hypoxia-inducible factor 1-alpha; ARNT-interacting protein; HIF-1-alpha; HIF1-alpha", "protein_names_refseq": "ARNT-interacting protein; hypoxia-inducible factor 1-alpha isoform 1; hypoxia-inducible factor 1-alpha", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); glycogen storage disease VII (Disease Ontology:DOID:11721); morbid obesity (Disease Ontology:DOID:11981); varicocele (Disease Ontology:DOID:12337); retinal ischemia (Disease Ontology:DOID:12510); hepatic encephalopathy (Disease Ontology:DOID:13413); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); glycogen storage disease V (Disease Ontology:DOID:2746); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); olfactory neuroblastoma (Disease Ontology:DOID:369); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); mycosis fungoides (Disease Ontology:DOID:8691); decubitus ulcer (Disease Ontology:DOID:8717); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15251); (R-MMU-1234158); (R-MMU-1234174); (R-MMU-1234176); (R-MMU-5689880); (R-MMU-8857538); (R-MMU-8951664)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "11707426;15225651;16777103;17981124;20889502;21546903;21750661;22009797;22100406;25428506;26245371;30084848;31219806;34428180;36210013;37558878;8660378;8702901;9210478;9368100", "class_list": "", "function": "Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:15225651, PubMed:17981124, PubMed:22009797). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:15225651, PubMed:17981124, PubMed:22009797, PubMed:22100406, PubMed:37558878). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 50, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08741;O08993;Q61664;Q61665;Q8C681;Q8CC19;Q8CCB6;Q8R385;Q9CYA8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0060574 intestinal epithelial cell maturation;GO:1903672 positive regulation of sprouting angiogenesis;GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:0003208 cardiac ventricle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61221-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61696-1", "uniprot_id": "HS71A_MOUSE", "mass": 70079.0, "length": 641, "protein_name": "Heat shock 70 kDa protein 1A", "gene_name": "Hspa1a", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 1A", "refseq_ac": "NP_034609", "gene_names_uniprotkb": "Hspa1a; Hsp70-3; Hsp70A1", "gene_names_refseq": "Hsp70-3; Hsp70.3; Hsp72; Hspa1a; hsp68; hsp70A1", "protein_names_uniprotkb": "Heat shock 70 kDa protein 1A; HSP70.3; Heat shock 70 kDa protein 3; Hsp68", "protein_names_refseq": "68 kDa heat shock protein; heat shock 70 kDa protein 1A; heat shock 70 kDa protein 3; heat shock 70kDa protein 1A; heat shock protein 1A; heat shock protein, 70 kDa 3; inducible heat shock protein 70", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); lymphoma (Disease Ontology:DOID:0060058); Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); paranoid schizophrenia (Disease Ontology:DOID:1229); vitiligo (Disease Ontology:DOID:12306); cardiovascular system disease (Disease Ontology:DOID:1287); Kawasaki disease (Disease Ontology:DOID:13378); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); systemic lupus erythematosus (Disease Ontology:DOID:9074); systolic heart failure (Disease Ontology:DOID:9651); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (mmu:193740); (R-MMU-3371453); (R-MMU-3371497); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-450408); (R-MMU-6798695); (R-MMU-9833482); (R-MMU-9841251)", "pathway_count": 9, "publication_count": 16, "publication_id_list": "14585845;14656967;19052621;21183079;23973223;27014269;2868009;31219806;34428180;34887587;35820727;35822049;35984892;37828378;38703814;8076831", "class_list": "", "function": "Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors., [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61697;Q7TQD8;Q9QWJ5", "ec_number_list": "", "go_molecular_function": "GO:0031249 denatured protein binding;GO:0055131 C3HC4-type RING finger domain binding;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0033120 positive regulation of RNA splicing;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q61696-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1M1-1", "uniprot_id": "IGS10_MOUSE", "mass": 285598.0, "length": 2594, "protein_name": "Immunoglobulin superfamily member 10", "gene_name": "Igsf10", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 10 precursor", "refseq_ac": "NP_001156356", "gene_names_uniprotkb": "Igsf10", "gene_names_refseq": "6530405F15Rik; 9030224D03; Adlican2; CMF608; Igsf10", "protein_names_uniprotkb": "Immunoglobulin superfamily member 10; IgSF10", "protein_names_refseq": "immunoglobulin superfamily member 10 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:242050)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27137492;30084848;34418053;34428180", "class_list": "", "function": "Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (PubMed:27137492). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPM4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042246 tissue regeneration;GO:0001503 ossification;GO:2001222 regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q3V1M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61371-1", "uniprot_id": "IFT88_MOUSE", "mass": 92994.0, "length": 824, "protein_name": "Intraflagellar transport protein 88 homolog", "gene_name": "Ift88", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 88 homolog isoform 1", "refseq_ac": "NP_033402", "gene_names_uniprotkb": "Ift88; Tg737Rpw; Tg737; TgN737Rpw; Ttc10", "gene_names_refseq": "Ift88; Tg737Rpw; Tg737; TgN737Rpw; Ttc10; flexo; fxo; orpk; polaris", "protein_names_uniprotkb": "Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737; TPR repeat protein 10; Tetratricopeptide repeat protein 10; TgN(Imorpk)737Rpw", "protein_names_refseq": "TPR repeat protein 10; intraflagellar transport 88 homolog; intraflagellar transport protein 88 homolog isoform 1; intraflagellar transport protein 88 homolog; recessive polycystic kidney disease protein Tg737; tetratricopeptide repeat domain 10; tetratricopeptide repeat protein 10; tgN(Imorpk)737Rpw; transgene insert site 737, insertional mutation, polycystic kidney disease", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); silicosis (Disease Ontology:DOID:10325); scimitar syndrome (Disease Ontology:DOID:4297); mitral valve disease (Disease Ontology:DOID:61); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:21821); (R-MMU-5610787); (R-MMU-5620924); (R-MMU-9646399)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "11062270;17312020;19253336;20230748;21289087;21750661;23386061;23810713;23955340;24089209;24469809;25428506;30084848;31219806;31761534;34124066;34428180;37352829;38038747;8191288", "class_list": "", "function": "Positively regulates primary cilium biogenesis (PubMed:11062270, PubMed:21289087, PubMed:31761534). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment., [UniProtKB, PubMed, PubMed, PubMed]; Positively regulates primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKU0;Q3UXY9;Q921J5", "ec_number_list": "", "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0021513 spinal cord dorsal/ventral patterning;GO:0001889 liver development;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35492-1", "uniprot_id": "HUTH_MOUSE", "mass": 72258.0, "length": 657, "protein_name": "Histidine ammonia-lyase", "gene_name": "Hal", "organism": "Mouse", "refseq_name": "histidine ammonia-lyase", "refseq_ac": "NP_034531", "gene_names_uniprotkb": "Hal; Hsd; Huth", "gene_names_refseq": "Hal; Hsd; histidase; his", "protein_names_uniprotkb": "Histidine ammonia-lyase; 4.3.1.3; Histidase", "protein_names_refseq": "histidine ammonia-lyase", "tax_id": 10090, "disease": "histidinemia (Disease Ontology:DOID:0060168)", "pathway": " (mmu:15109); (R-MMU-70921)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17242355;20686493;21183079;21750661;30084848;34428180;8486363", "class_list": "", "function": "Photoprotective role of endogenous urocanic acid in the murine skin using histidinemic mice, in which the gene encoding histidase is mutated, [RefSeq, PubMed]; This gene encodes a member of the histidase protein family. The encoded protein is a cytosolic enzyme which catalyzes the first reaction in histidine catabolism. Defects in this protein cause histidinemia, which is characterized by increased histidine in blood, urine, and cerebrospinal fluid. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.3.1.3", "go_molecular_function": "GO:0004397 histidine ammonia-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHR7-1", "uniprot_id": "IDE_MOUSE", "mass": 117772.0, "length": 1019, "protein_name": "Insulin-degrading enzyme", "gene_name": "Ide", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ide", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin-degrading enzyme; 3.4.24.56; Insulin protease; Insulinase; Insulysin", "protein_names_refseq": "", "tax_id": 10090, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-MMU-5689880); (R-MMU-77387); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12634421;12732730;21576244;22504074;23806337;24847884;26394692;31219806;34428180;37828378;9830016", "class_list": "", "function": "Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:12634421, PubMed:12732730, PubMed:24847884, PubMed:26394692, PubMed:9830016). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (PubMed:24847884, PubMed:26394692). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:9830016). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (By similarity). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (By similarity). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;5.2.1.8;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;3.4.23.5;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;3.4.19.12;3.6.5.-;1.5.3.13;3.1.1.29;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0031626 beta-endorphin binding;GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0010992 ubiquitin recycling;GO:1901142 insulin metabolic process;GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0050435 amyloid-beta metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JHR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JII1-1", "uniprot_id": "INP5E_MOUSE", "mass": 71915.0, "length": 647, "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "gene_name": "Inpp5e", "organism": "Mouse", "refseq_name": "phosphatidylinositol polyphosphate 5-phosphatase type IV isoform b", "refseq_ac": "NP_001277366", "gene_names_uniprotkb": "Inpp5e", "gene_names_refseq": "1200002L24Rik; 72kDa; Inpp5e; mKIAA0123", "protein_names_uniprotkb": "Phosphatidylinositol polyphosphate 5-phosphatase type IV; 3.1.3.36; 3.1.3.86; 72 kDa inositol polyphosphate 5-phosphatase; Inositol polyphosphate-5-phosphatase E; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "protein_names_refseq": "72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate-5-phosphatase, 72 kDa; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV isoform b; phosphatidylinositol polyphosphate 5-phosphatase type IV; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); Joubert syndrome 1 (Disease Ontology:DOID:0110980); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:64436); (R-MMU-1660514); (R-MMU-5624958)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10806194;19668215;21183079;21750661;26051944;35196065", "class_list": "", "function": "Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10806194). Can also remove the 5-phosphate from 1D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) (By similarity). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (PubMed:19668215)., [UniProtKB, UniProtKB, PubMed, PubMed]; Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCC9", "ec_number_list": "3.1.3.67;3.1.3.86;3.1.3.95;3.1.3.36;3.1.3.56;3.1.3.-;3.1.3.16", "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0017148 negative regulation of translation;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046856 phosphatidylinositol dephosphorylation;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JII1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47873-1", "uniprot_id": "IL11_MOUSE", "mass": 21522.0, "length": 199, "protein_name": "Interleukin-11", "gene_name": "Il11", "organism": "Mouse", "refseq_name": "interleukin-11 isoform 1 precursor", "refseq_ac": "NP_032376", "gene_names_uniprotkb": "Il11", "gene_names_refseq": "IL-11; Il11", "protein_names_uniprotkb": "Interleukin-11; IL-11", "protein_names_refseq": "interleukin-11 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:16156); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10026196;21750661;22253262;23948300;38758184;39020175;39294742;39358385;8913282", "class_list": "", "function": "Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina. Publication Status: Online-Only, [RefSeq, PubMed]; Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:22253262, PubMed:23948300). The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Inhibition of IL-11 signalling extends mammalian healthspan and lifespan., [RefSeq, PubMed]; Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Mesenchymal stromal cells protect tissues from Th1 immune responses via IL-11 secretion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005142 interleukin-11 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0043235 receptor complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046888 negative regulation of hormone secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47873-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35664-1", "uniprot_id": "INAR2_MOUSE", "mass": 56578.0, "length": 513, "protein_name": "Interferon alpha/beta receptor 2", "gene_name": "Ifnar2", "organism": "Mouse", "refseq_name": "interferon alpha/beta receptor 2 isoform b precursor", "refseq_ac": "NP_001103968", "gene_names_uniprotkb": "Ifnar2", "gene_names_refseq": "IFN-R-2; Ifnar-2; Ifnar2", "protein_names_uniprotkb": "Interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; Type I interferon receptor 2", "protein_names_refseq": "IFN-alpha/beta receptor 2; interferon alpha/beta receptor 2 isoform b precursor; interferon alpha/beta receptor 2; interferon receptor 2a'; interferon receptor 2c; type I interferon alpha/beta receptor 2a; type I interferon receptor 2", "tax_id": 10090, "disease": "immunodeficiency 45 (Disease Ontology:DOID:0111994); hepatitis B (Disease Ontology:DOID:2043)", "pathway": " (mmu:15976); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11939908;16944957;19144319;21750661;30084848;33552080;9295335;9322767", "class_list": "", "function": "Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. Review article Publication Status: Online-Only, [RefSeq, PubMed]; May be potent inhibitors of type I IFN receptor activity., [UniProtKB, PubMed, PubMed]; Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9704, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O35238;O35663;O35983;Q923Z5", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019955 cytokine binding;GO:0004905 type I interferon receptor activity;GO:0019962 type I interferon binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:1900182 positive regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35664-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09535-1", "uniprot_id": "IGF2_MOUSE", "mass": 20030.0, "length": 180, "protein_name": "Insulin-like growth factor 2", "gene_name": "Igf2", "organism": "Mouse", "refseq_name": "insulin-like growth factor 2 isoform 2 preproprotein", "refseq_ac": "NP_001116208", "gene_names_uniprotkb": "Igf2; Igf-2", "gene_names_refseq": "Igf-2; Igf-II; Igf2; M6pr; Mpr; Peg2", "protein_names_uniprotkb": "Insulin-like growth factor 2; IGF-II; Insulin-like growth factor II; Multiplication-stimulating polypeptide", "protein_names_refseq": "insulin-like growth factor 2 isoform 2 preproprotein; insulin-like growth factor II; multiplication-stimulating polypeptide", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol-associated liver disease (Disease Ontology:DOID:0070658); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); Silver-Russell syndrome (Disease Ontology:DOID:14681); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); ventricular septal defect (Disease Ontology:DOID:1657); multiple sclerosis (Disease Ontology:DOID:2377); brain infarction (Disease Ontology:DOID:3454); choriocarcinoma (Disease Ontology:DOID:3594); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); multiple system atrophy (Disease Ontology:DOID:4752); liver cirrhosis (Disease Ontology:DOID:5082); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16002); (R-MMU-114608); (R-MMU-2404192); (R-MMU-2428928); (R-MMU-2428933); (R-MMU-381426)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "11716772;12087403;16901893;16912056;1702294;19706595;1997210;21750661;2330056;24593700;2537977;28522536;29440408;32557799;34203471;3780370;8265819;9039503", "class_list": "", "function": "Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The insulin-like growth factors possess growth-promoting activity (PubMed:29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed:12087403, PubMed:2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed:16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed:32557799)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLW5", "ec_number_list": "", "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P09535-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70227-1", "uniprot_id": "ITPR3_MOUSE", "mass": 304275.0, "length": 2670, "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3", "gene_name": "Itpr3", "organism": "Mouse", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR3", "refseq_ac": "NP_542120", "gene_names_uniprotkb": "Itpr3", "gene_names_refseq": "IP3R 3; IP3R-3; Ip3r3; Itpr-3; Itpr3; tf", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; IP3 receptor isoform 3; IP3R-3; Inositol 1,4,5-trisphosphate receptor type 3; InsP3R3; Type 3 InsP3 receptor; Type 3 inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "IP3 receptor; inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; type 3 InsP3 receptor; type 3 inositol 1,4,5-trisphosphate receptor", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); immunodeficiency 133 (Disease Ontology:DOID:0061096); pre-eclampsia (Disease Ontology:DOID:10591); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); gestational diabetes (Disease Ontology:DOID:11714); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16440); (R-MMU-114508); (R-MMU-139853); (R-MMU-381676); (R-MMU-5578775); (R-MMU-9717207); (R-MMU-983695)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11149946;1374893;15632133;17242355;20071408;20813840;20843799;21030605;21183079;23650607;25428506;25605945;29187734;30084848;31219806;33300544;34428180;36210013;9065779", "class_list": "", "function": "Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:15632133, PubMed:20813840, PubMed:9065779). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (By similarity). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5DWM4;Q8CED5;Q91Z08", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007613 memory;GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P70227-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63ZW7-1", "uniprot_id": "INADL_MOUSE", "mass": 198517.0, "length": 1834, "protein_name": "InaD-like protein", "gene_name": "Patj", "organism": "Mouse", "refseq_name": "inaD-like protein isoform 2", "refseq_ac": "NP_001005784", "gene_names_uniprotkb": "Patj; Cipp; Inadl", "gene_names_refseq": "Cipp; Inadl; Patj", "protein_names_uniprotkb": "InaD-like protein; Channel-interacting PDZ domain-containing protein; Inadl protein; Pals1-associated tight junction protein; Protein associated to tight junctions", "protein_names_refseq": "PALS1-associated tight junction protein; channel-interacting PDZ domain protein; channel-interacting PDZ domain-containing protein; inaD-like protein isoform 2; inaD-like protein; inactivation no after-potential D-like protein; novel ankyrin-repeat protein; protein associated to tight junctions", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:12695)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11872753;12403818;12527193;14988405;15466885;17242355;17452640;20399730;21183079;21750661;30059200;30084848;34428180;36210013;37318097;9647694", "class_list": "", "function": "PATJ and MPDZ are required for trophectoderm lineage specification in early mouse embryos. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11872753). Required for the correct formation of tight junctions and epithelial apico-basal polarity (By similarity). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (PubMed:11872753). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Scaffolding protein that facilitates the localization of proteins to the cell membrane. Required for the correct formation of tight junctions and epithelial apico-basal polarity. Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier. Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells. Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries., [UniProtKB, UniProtKB]; This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ADS7;O70471;Q5PRG3;Q6P6J1;Q80YR8;Q8BPB9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction", "go_biological_process": "GO:0120192 tight junction assembly;GO:0035089 establishment of apical/basal cell polarity", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q63ZW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKC5-1", "uniprot_id": "IPO5_MOUSE", "mass": 123591.0, "length": 1097, "protein_name": "Importin-5", "gene_name": "Ipo5", "organism": "Mouse", "refseq_name": "importin-5 isoform 1", "refseq_ac": "NP_076068", "gene_names_uniprotkb": "Ipo5; Kpnb3; Ranbp5", "gene_names_refseq": "1110011C18Rik; 5730478E03Rik; IMB3; Ipo5; Kpnb3; Ranbp5; imp5", "protein_names_uniprotkb": "Importin-5; Imp5; Importin subunit beta-3; Karyopherin beta-3; Ran-binding protein 5; RanBP5", "protein_names_refseq": "RAN binding protein 5; importin beta 3; importin subunit beta-3; importin-5 isoform 1; karyopherin (importin) beta 3; karyopherin beta-3", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:70572)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11493596;17143267;20173027;21183079;22730302;23541588;25153642;25428506;25605945;26689472;28528544;30084848;31219806;33300544;34428180;36120598;37453647;37507081;39627609", "class_list": "", "function": "Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (PubMed:22730302)., [UniProtKB, PubMed, PubMed, PubMed]; IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEG2;Q7TQC6;Q9EQ30", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0006610 ribosomal protein import into nucleus;GO:0071230 cellular response to amino acid stimulus;GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BKC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54071-1", "uniprot_id": "IDHP_MOUSE", "mass": 50906.0, "length": 452, "protein_name": "Isocitrate dehydrogenase [NADP], mitochondrial", "gene_name": "Idh2", "organism": "Mouse", "refseq_name": "isocitrate dehydrogenase [NADP], mitochondrial precursor", "refseq_ac": "NP_766599", "gene_names_uniprotkb": "Idh2", "gene_names_refseq": "E430004F23; IDPm; Idh-2; Idh2", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP], mitochondrial; 1.1.1.42; ICD-M; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase", "protein_names_refseq": "ICD-M; IDH; IDP; NADP(+)-specific ICDH; NADP+-specific isocitrate dehydrogenase; isocitrate dehydrogenase [NADP], mitochondrial precursor; isocitrate dehydrogenase [NADP], mitochondrial; oxalosuccinate decarboxylase", "tax_id": 10090, "disease": "bone remodeling disease (Disease Ontology:DOID:0080005); D-2-hydroxyglutaric aciduria 2 (Disease Ontology:DOID:0111352); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:269951); (R-MMU-2151201); (R-MMU-71403); (R-MMU-9837999); (R-MMU-9854311)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "11278619;21750661;23576753;23806337;28528544;31219806;34428180;35820727;36288343;37453647;37507081;39256649;39927985;8867815", "class_list": "", "function": "IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in intermediary metabolism and energy production (PubMed:8867815). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:8867815)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2R9;Q9EQK1", "ec_number_list": "3.5.3.1;1.8.1.4;5.3.3.21;3.1.2.-;3.1.2.2;3.4.21.92;1.1.1.42;1.1.1.37;1.15.1.1;4.98.1.1;1.4.1.3;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;1.1.1.35;1.1.1.30;2.7.11.2;2.3.1.9;2.3.1.-;2.3.1.286;2.3.1.37;7.1.1.2;1.1.1.38;4.2.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;6.2.1.-;6.2.1.1;6.2.1.17;6.2.1.4", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006741 NADP+ biosynthetic process;GO:1903976 negative regulation of glial cell migration;GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:0006099 tricarboxylic acid cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P54071-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08581-1", "uniprot_id": "KCNK1_MOUSE", "mass": 38201.0, "length": 336, "protein_name": "Potassium channel subfamily K member 1", "gene_name": "Kcnk1", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 1", "refseq_ac": "NP_032456", "gene_names_uniprotkb": "Kcnk1", "gene_names_refseq": "Kcnk1; TWIK-1", "protein_names_uniprotkb": "Potassium channel subfamily K member 1; Inward rectifying potassium channel protein TWIK-1", "protein_names_refseq": "inward rectifying potassium channel protein TWIK-1; potassium channel subfamily K member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16525); (R-MMU-1299308); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "12855359;15540117;16025300;16847696;17079103;17114649;18222039;19959478;21750661;22431633;24368895;24496152;25339226;25406588;25530075;34685731;36291187;9013852;9559671", "class_list": "", "function": "Beta-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:16847696, PubMed:22431633, PubMed:24368895). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:24496152, PubMed:9013852). Channel activity is modulated by activation of serotonin receptors (PubMed:24368895). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (PubMed:24496152). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (PubMed:25406588). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (PubMed:25406588). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G protein-coupled receptors, such as F2R and CNR1 (PubMed:24496152). Required for normal ion and water transport in the kidney (PubMed:16025300). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (PubMed:22431633). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:15540117). Permeable to monovalent cations with ion selectivity for K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Specifically localized in 'non-sensory' cells of inner ear, in dark cells of vestibule and in strial marginal cells of cochlea. May have role in regulation of K(+) homeostasis in dark cells and in strial marginal cells., [RefSeq, PubMed]; TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 Expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99L99", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005267 potassium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0034705 potassium channel complex;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035094 response to nicotine;GO:0006813 potassium ion transport;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0014047 glutamate secretion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O08581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H8H5-1", "uniprot_id": "KCNB2_MOUSE", "mass": 102336.0, "length": 907, "protein_name": "Potassium voltage-gated channel subfamily B member 2", "gene_name": "Kcnb2", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily B member 2", "refseq_ac": "NP_001091998", "gene_names_uniprotkb": "Kcnb2", "gene_names_refseq": "9630047L19Rik; Kcnb2; Kv2.2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2", "protein_names_refseq": "potassium voltage-gated channel subfamily B member 2; voltage-gated potassium channel subunit Kv2.2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (mmu:98741); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10414301;18511484;30091655;35820727", "class_list": "", "function": "It was concluded that Kv2.2-containing channels have a distinctive initial segment location and crucial function in maintaining AP amplitude by regulating the interspike potential during high frequency firing., [RefSeq, PubMed]; These findings demonstrate a conserved in vivo function for Kv2 family members in remodeling neuronal endoplasmic reticulum-plasma membrane junctions., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q5T7", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046982 protein heterodimerization activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0072659 protein localization to plasma membrane;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A6H8H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05627-1", "uniprot_id": "JUN_MOUSE", "mass": 35944.0, "length": 334, "protein_name": "Transcription factor Jun", "gene_name": "Jun", "organism": "Mouse", "refseq_name": "transcription factor Jun", "refseq_ac": "NP_034721", "gene_names_uniprotkb": "Jun", "gene_names_refseq": "AP-1; Junc; Jun; c-jun", "protein_names_uniprotkb": "Transcription factor Jun; AH119; AP1; Activator protein 1; Jun A; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog", "protein_names_refseq": "AH119; AP1; Jun oncogene; V-jun avian sarcoma virus 17 oncogene homolog; activator protein 1; immediate early; jun A; jun proto-oncogene; proto-oncogene c-jun; transcription factor AP-1 subunit Jun; transcription factor AP-1; transcription factor Jun", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); pulmonary tuberculosis (Disease Ontology:DOID:2957); renal cell carcinoma (Disease Ontology:DOID:4450); renal carcinoma (Disease Ontology:DOID:4451); Hodgkin's lymphoma (Disease Ontology:DOID:8567); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:16476); (R-MMU-2559580); (R-MMU-2871796); (R-MMU-450341)", "pathway_count": 4, "publication_count": 69, "publication_id_list": "10080190;10851065;11397794;11704680;11909946;12040039;12169099;14707112;15081267;15147972;15172983;15711095;16061693;16740738;17210646;19118012;19144319;19525941;19649203;20395206;20516211;20852630;21177766;21183079;21750661;21783678;21948257;22159078;22539006;22606284;22933572;22992673;23041047;23139803;23501261;23806337;24349637;24466034;2457172;24742962;2498083;25428506;26091349;26469961;26948947;27257624;27458189;27531992;27795299;29079852;29237092;29272704;30012597;3136397;31434493;31450635;31776360;3186736;32038174;32117051;32719328;33898323;34428180;35567901;7499226;8055649;9022811;9447996;9779822", "class_list": "", "function": "Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:14707112). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (PubMed:2498083). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005096 GTPase activator activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0019046 release from viral latency;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 7.5, "record_id": "P05627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TS72-1", "uniprot_id": "IP3KC_MOUSE", "mass": 74493.0, "length": 678, "protein_name": "Inositol-trisphosphate 3-kinase C", "gene_name": "Itpkc", "organism": "Mouse", "refseq_name": "inositol-trisphosphate 3-kinase C", "refseq_ac": "NP_853624", "gene_names_uniprotkb": "Itpkc", "gene_names_refseq": "9130023N17Rik; IP3K C; Itpkc", "protein_names_uniprotkb": "Inositol-trisphosphate 3-kinase C; 2.7.1.127; IP3 3-kinase C; IP3K C; Inositol 1,4,5-trisphosphate 3-kinase C; InsP 3-kinase C", "protein_names_refseq": "IP3 3-kinase C; inositol-trisphosphate 3-kinase C; insP 3-kinase C", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:233011); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17355905;21183079;27036498;35820727", "class_list": "", "function": "Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (By similarity). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The expression of ITPKC in various ciliated tissues suggest a role for the enzyme either in the development or in the function of these specialized cellular structures., [RefSeq, PubMed]; These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U384", "ec_number_list": "2.7.1.127", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TS72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WQ4-1", "uniprot_id": "TRM9B_MOUSE", "mass": 50277.0, "length": 447, "protein_name": "Probable tRNA methyltransferase 9B", "gene_name": "Trmt9b", "organism": "Mouse", "refseq_name": "probable tRNA methyltransferase 9B isoform 1", "refseq_ac": "NP_795926", "gene_names_uniprotkb": "Trmt9b; Kiaa1456; Trmt9l", "gene_names_refseq": "6430573F11Rik; Kiaa1456; TRM9L; Trmt9b", "protein_names_uniprotkb": "Probable tRNA methyltransferase 9B; 2.1.1.-; Probable tRNA methyltransferase 9-like protein", "protein_names_refseq": "probable tRNA methyltransferase 9-like protein; probable tRNA methyltransferase 9B isoform 1; probable tRNA methyltransferase 9B", "tax_id": 10090, "disease": "", "pathway": " (mmu:319582)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTX8;Q8CA94;Q8CAM3", "ec_number_list": "", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0000049 tRNA binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0106335 tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80WQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BT20-1", "uniprot_id": "ISK6_MOUSE", "mass": 11609.0, "length": 105, "protein_name": "Serine protease inhibitor Kazal-type 6", "gene_name": "Spink6", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 6 isoform 1 precursor", "refseq_ac": "NP_001013819", "gene_names_uniprotkb": "Spink6", "gene_names_refseq": "EG433180; Spink6", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 6", "protein_names_refseq": "serine protease inhibitor Kazal-type 6 isoform 1 precursor; serine protease inhibitor Kazal-type 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:433180); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;24352040", "class_list": "", "function": "Our study indicates that Spink6 is a potent inhibitor of kallikrein related peptidases and involved in skin barrier function., [RefSeq, PubMed]; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK5 and human KLK2, KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit human KLK1 and KLK8., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045861 negative regulation of proteolysis;GO:1900004 negative regulation of serine-type endopeptidase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BT20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXM1-1", "uniprot_id": "JMY_MOUSE", "mass": 110586.0, "length": 983, "protein_name": "Junction-mediating and -regulatory protein", "gene_name": "Jmy", "organism": "Mouse", "refseq_name": "junction-mediating and -regulatory protein", "refseq_ac": "NP_067285", "gene_names_uniprotkb": "Jmy", "gene_names_refseq": "Jmy", "protein_names_uniprotkb": "Junction-mediating and -regulatory protein", "protein_names_refseq": "junction-mediating and -regulatory protein; p300 transcriptional cofactor JMY", "tax_id": 10090, "disease": "", "pathway": " (mmu:57748); (R-MMU-6804760)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10518217;11511361;17170761;17242355;19287377;19897726;21183079;21266449;21750661;23552571;25015719;30463620;31219806;32152506;32279424", "class_list": "", "function": "Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (By similarity). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; JMY activates MRTF-SRF independently of F-actin via WH2/V-mediated competition with the RPEL region for G-actin binding in the cytoplasm Publication Status: Online-Only, [RefSeq, PubMed]; JMY drives vesicular trafficking in the trans-Golgi region and at ER-membrane contact sites, distinct from other Arp2/3 activators involved in vesicle transport processes such as the related WHAMM or WASH., [RefSeq, PubMed]; JMY expression by Sertoli cells contributes to mediating spermatogenesis in mice., [RefSeq, PubMed]; JMY is required for spindle migration, asymmetric division and cytokinesis during mouse oocyte maturation., [RefSeq, PubMed]; Results of the present study show that the nucleation-promoting factors JMY and WAVE2 are critical for cytokinesis during development of mouse embryos., [RefSeq, PubMed]; These results define a new functional relationship between the p53 cofactor JMY and Mdm2, and indicate that transcription cofactors that facilitate p53 activity are important targets for Mdm2 in suppressing the p53 response., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQZ0;Q5BL16;Q6NST0;Q8CBP9;Q8VDZ3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0031252 cell leading edge", "go_biological_process": "GO:0070358 actin polymerization-dependent cell motility;GO:0070060 'de novo' actin filament nucleation;GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NCY0-1", "uniprot_id": "KDM6B_MOUSE", "mass": 176355.0, "length": 1641, "protein_name": "Lysine-specific demethylase 6B", "gene_name": "Kdm6b", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 6B", "refseq_ac": "NP_001017426", "gene_names_uniprotkb": "Kdm6b; Jmjd3; Kiaa0346", "gene_names_refseq": "1700064E03Rik; Jmjd3; Kdm6b", "protein_names_uniprotkb": "Lysine-specific demethylase 6B; 1.14.11.68; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; [histone H3]-trimethyl-L-lysine(27) demethylase 6B", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(27) demethylase 6B; jmjC domain-containing protein 3; jumonji domain containing 3; jumonji domain-containing protein 3; lysine-specific demethylase 6B", "tax_id": 10090, "disease": "Stolerman neurodevelopmental syndrome (Disease Ontology:DOID:0081443); alcohol use disorder (Disease Ontology:DOID:1574); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:216850); (R-MMU-2559580); (R-MMU-3214842)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "17825402;17928865;18003914;21095589;32042044;34203471;34428180;34678516;36852467;40997131;41485575;9854018", "class_list": "", "function": "Data reveal that SMRT represses expression of JMJD3, a direct retinoic-acid-receptor target that functions as a histone H3 trimethyl K27 demethylase and which is capable of activating specific components of the neurogenic program, [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (PubMed:21095589)., [UniProtKB, PubMed, PubMed]; Jmjd3 binds polycomb group protein target genes and regulates their histone H3 lysine 27 trimethylation levels and transcriptional activity. Provides a link between inflammation and reprogramming of the epigenome., [RefSeq, PubMed]; UTX and JMJD3 may function as H3K27 demethylases in vivo GeneRIF: JMJD3 demethylates di- and trimethylated lysine 27 of histone H3 in vitro and in cells., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWY9;Q4VC26;Q6ZQD3", "ec_number_list": "1.14.11.68;1.14.11.65", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008013 beta-catenin binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002437 inflammatory response to antigenic stimulus;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5NCY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHI5-1", "uniprot_id": "IVD_MOUSE", "mass": 46325.0, "length": 424, "protein_name": "Isovaleryl-CoA dehydrogenase, mitochondrial", "gene_name": "Ivd", "organism": "Mouse", "refseq_name": "isovaleryl-CoA dehydrogenase, mitochondrial isoform 1 precursor", "refseq_ac": "NP_062800", "gene_names_uniprotkb": "Ivd", "gene_names_refseq": "1300016K07Rik; 6720455E18Rik; Ivd", "protein_names_uniprotkb": "Isovaleryl-CoA dehydrogenase, mitochondrial; 1.3.8.1; 1.3.8.4; Butyryl-CoA dehydrogenase; IVD", "protein_names_refseq": "butyryl-CoA dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial isoform 1 precursor; isovaleryl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "isovaleric acidemia (Disease Ontology:DOID:14753); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:56357); (R-MMU-70895)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11404023;23576753;23806337;31599954;34428180;35820727;36288343;37453647;37507081;39927985", "class_list": "", "function": "A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYI3;Q9DBD7", "ec_number_list": "1.3.8.7;1.3.8.8;1.3.8.1;1.3.8.5;1.3.8.4", "go_molecular_function": "GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0009083 branched-chain amino acid catabolic process;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JHI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q9D5-2", "uniprot_id": "RBL2A_MOUSE", "mass": 25610.0, "length": 223, "protein_name": "Rab-like protein 2A", "gene_name": "Rabl2", "organism": "Mouse", "refseq_name": "rab-like protein 2A", "refseq_ac": "NP_081093", "gene_names_uniprotkb": "Rabl2; Rabl2a", "gene_names_refseq": "1110031N17Rik; Rabl2a; Rabl2", "protein_names_uniprotkb": "Rab-like protein 2A; 3.6.5.2", "protein_names_refseq": "RAB, member of RAS oncogene family-like 2A; rab-like protein 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68708)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23055941;28625565;33075816;33241915", "class_list": "", "function": "CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange., [RefSeq, PubMed]; Our data demonstrate a novel function for the RABL protein family, an essential role for RABL2 in male fertility and a previously uncharacterised mechanism for protein delivery to the flagellum., [RefSeq, PubMed]; Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling., [RefSeq, PubMed]; Small GTPase that plays an essential role in male fertility, sperm intra-flagellar transport, and sperm tail assembly (PubMed:23055941). Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail., [UniProtKB, PubMed]; Variants in RABL2A causing male infertility and ciliopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDG7;Q8K2P9;Q9D133", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0012505 endomembrane system;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030317 flagellated sperm motility;GO:0007338 single fertilization;GO:0060271 cilium assembly;GO:0008594 photoreceptor cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q9D5-2", "record_type": "protein" }, { "uniprot_canonical_ac": "P17433-1", "uniprot_id": "SPI1_MOUSE", "mass": 31349.0, "length": 272, "protein_name": "Transcription factor PU.1", "gene_name": "Spi1", "organism": "Mouse", "refseq_name": "transcription factor PU.1 isoform 2", "refseq_ac": "NP_035485", "gene_names_uniprotkb": "Spi1; Sfpi-1; Sfpi1", "gene_names_refseq": "Dis-1; Dis1; PU.1; Sfpi-1; Sfpi1; Spi-1; Spi1; Tcfpu1; Tfpu.1", "protein_names_uniprotkb": "Transcription factor PU.1; 31 kDa-transforming protein; SFFV proviral integration 1 protein", "protein_names_refseq": "31 kDa-transforming protein; SFFV proviral integration 1 protein; hematopoietic transcription factor PU.1; spleen focus forming virus (SFFV) proviral integration oncogene; transcription factor PU.1 isoform 2", "tax_id": 10090, "disease": "agammaglobulinemia 10 (Disease Ontology:DOID:0081142); alcohol use disorder (Disease Ontology:DOID:1574); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:20375)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12612065;17197705;19144319;1985210;21750661;2180582;2594367;34428180;36210013;38734693;7594592;7797077;8079170;8602247;8626664;9029125", "class_list": "", "function": "Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Abeta amyloidosis. Publication Status: Online-Only, [RefSeq, PubMed]; Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites (PubMed:8079170). Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:8079170). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:2180582). In vitro can bind RNA and interfere with pre-mRNA splicing (PubMed:8626664)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L57", "ec_number_list": "", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0051525 NFAT protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0002573 myeloid leukocyte differentiation;GO:0030851 granulocyte differentiation;GO:1904238 pericyte cell differentiation;GO:0002327 immature B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P17433-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCW4-1", "uniprot_id": "UN93B_MOUSE", "mass": 66981.0, "length": 598, "protein_name": "Protein unc-93 homolog B1", "gene_name": "Unc93b1", "organism": "Mouse", "refseq_name": "protein unc-93 homolog B1 isoform b", "refseq_ac": "NP_001154900", "gene_names_uniprotkb": "Unc93b1; Unc93b", "gene_names_refseq": "Unc-93B1; Unc93b1; Unc93b", "protein_names_uniprotkb": "Protein unc-93 homolog B1; Unc-93B1", "protein_names_refseq": "protein unc-93 homolog B1 isoform b; protein unc-93 homolog B1", "tax_id": 10090, "disease": "brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:54445); (R-MMU-1679131)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16415873;17452530;18305481;19451267;21750661;26495903;26740625;29187734;33432245;9798653", "class_list": "", "function": "Identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9, [RefSeq, PubMed]; Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 26, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O89077;Q3TNR9;Q710D2;Q8CIK1;Q8R3D0", "ec_number_list": "", "go_molecular_function": "GO:0035325 Toll-like receptor binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane;GO:0032009 early phagosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VCW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26361-1", "uniprot_id": "CFTR_MOUSE", "mass": 167870.0, "length": 1476, "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "Cftr", "organism": "Mouse", "refseq_name": "cystic fibrosis transmembrane conductance regulator", "refseq_ac": "NP_066388", "gene_names_uniprotkb": "Cftr; Abcc7", "gene_names_refseq": "Abcc7; Cftr", "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; ATP-binding cassette sub-family C member 7; CFTR; Channel conductance-controlling ATPase; cAMP-dependent chloride channel", "protein_names_refseq": "ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); bronchiectasis 1 (Disease Ontology:DOID:0080526); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111862); autosomal recessive congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111864); cholelithiasis (Disease Ontology:DOID:10211); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); lung cancer (Disease Ontology:DOID:1324); typhoid fever (Disease Ontology:DOID:13258); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); duodenal ulcer (Disease Ontology:DOID:1724); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); alcoholic pancreatitis (Disease Ontology:DOID:4988); salpingitis (Disease Ontology:DOID:5733); dental enamel hypoplasia (Disease Ontology:DOID:693); gastrointestinal system disease (Disease Ontology:DOID:77); lung disease (Disease Ontology:DOID:850); diabetes mellitus (Disease Ontology:DOID:9351); bronchiectasis (Disease Ontology:DOID:9563)", "pathway": " (mmu:12638); (R-MMU-382556); (R-MMU-5627083); (R-MMU-5689880); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9013406); (R-MMU-9646399)", "pathway_count": 8, "publication_count": 21, "publication_id_list": "10655503;14685259;15619636;1712752;1716243;19033647;20231442;21183079;21750661;21884936;21976599;22265409;23542070;25428506;26823428;30084848;30659401;35820727;7526924;7685652;7691356", "class_list": "", "function": "Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:20231442, PubMed:22265409). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (By similarity). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This gene encodes the cystic fibrosis transmembrane regulator and a chloride channel that controls the regulation of other transport pathways. Mutations in this gene have been associated with autosomal recessive disorders such as cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternative splicing of exons 4, 5, and 11 have been observed, but full-length transcripts have not yet been fully described. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63893;Q63894;Q9JKQ6", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;7.6.2.2;7.6.2.-;7.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;3.4.19.12;7.6.2.1;3.6.1.5;3.4.25.1;3.4.24.-;3.6.-.-;3.6.5.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.5.2;3.6.5.5;3.6.4.6;2.3.2.23;3.6.1.15;3.1.4.-;2.7.10.1;5.6.2.-;7.2.2.-;2.7.11.1;7.6.2.16;2.7.1.153;2.7.1.137;2.7.1.154;3.1.3.86;3.1.3.56;3.1.3.36;3.1.3.-;1.8.-.-;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.1.2.-;3.5.1.-;3.5.1.124;2.3.2.31;1.8.5.1", "go_molecular_function": "GO:0005260 intracellularly ATP-gated chloride channel activity;GO:0019869 chloride channel inhibitor activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0030324 lung development;GO:0042311 vasodilation;GO:1904322 cellular response to forskolin;GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P26361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61602-1", "uniprot_id": "GLI3_MOUSE", "mass": 171655.0, "length": 1583, "protein_name": "Transcription activator GLI3", "gene_name": "Gli3", "organism": "Mouse", "refseq_name": "transcriptional activator GLI3", "refseq_ac": "NP_032156", "gene_names_uniprotkb": "Gli3", "gene_names_refseq": "Bph; GLI3-190; GLI3FL; Gli3; Pdn; Xt; add", "protein_names_uniprotkb": "Transcription activator GLI3; GLI3 C-terminally truncated form; GLI3 form of 190 kDa; GLI3 form of 83 kDa; GLI3 full-length protein; GLI3-190; GLI3-83; GLI3FL", "protein_names_refseq": "GLI3 form of 190 kDa; GLI3 full length protein; anterior digit pattern deformity; brachyphalangy; extra toes; polydactyly Nagoya; transcriptional activator GLI3; zinc finger protein GLI3", "tax_id": 10090, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly type IV (Disease Ontology:DOID:0060985); hypospadias (Disease Ontology:DOID:10892); syndactyly (Disease Ontology:DOID:11193); polydactyly (Disease Ontology:DOID:1148); clubfoot (Disease Ontology:DOID:11836); anodontia (Disease Ontology:DOID:13714); Greig cephalopolysyndactyly syndrome (Disease Ontology:DOID:14761); liver cirrhosis (Disease Ontology:DOID:5082); Pallister-Hall syndrome (Disease Ontology:DOID:9248)", "pathway": " (mmu:14634); (R-MMU-5610785); (R-MMU-5610787); (R-MMU-5632684)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10051311;10693759;11053430;16611981;17400206;19389374;19549984;19592253;19622347;1983115;20360384;20956384;21750661;23955340;24129315;29263200;31219806;32782141;36852467;38261656;8387379;8688459;9731531", "class_list": "", "function": "Major transcription repressor, which inhibits expression of target genes in the absence of smoothened (SMO) signaling (PubMed:10693759, PubMed:16611981). Generated by proteolytic processing of the full-length GLI3 form in the absence of hedgehog (DHH, IHH or SHH), when SMO transducer is inhibited (PubMed:10693759, PubMed:16611981). Constitutes the major form of GLI3, while the transcription activator form only plays a minor role (PubMed:10693759)., [UniProtKB, PubMed, PubMed]; Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in the development and patterning of various body structures, including the brain and limbs (PubMed:10693759, PubMed:11053430, PubMed:17400206, PubMed:19389374, PubMed:20360384). Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA-3' to activate or repress the expression of target genes (PubMed:11053430). Functions both as a transcriptional activator and repressor: the full-length GLI3 form (Transcription activator GLI3) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI3R, which is generated in absence of smoothened, acts as a transcription repressor (By similarity). The repressor form (GLI3R) constitutes the major form of GLI3 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Transcription factor, which activates expression of target genes in response to smoothened (SMO) activation (PubMed:19389374). Constitutes a minor form of GLI3, while the transcription repressor form (GLI3R) plays a major role (By similarity). In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 11, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0021544 subpallium development;GO:0007442 hindgut morphogenesis;GO:0021861 forebrain radial glial cell differentiation;GO:0022018 lateral ganglionic eminence cell proliferation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q61602-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMB0-1", "uniprot_id": "GKAP1_MOUSE", "mass": 41763.0, "length": 366, "protein_name": "G kinase-anchoring protein 1", "gene_name": "Gkap1", "organism": "Mouse", "refseq_name": "G kinase-anchoring protein 1", "refseq_ac": "NP_062806", "gene_names_uniprotkb": "Gkap1; Gkap42", "gene_names_refseq": "42kDa; 4933400B15Rik; D13Ertd340e; Gkap1; Gkap42", "protein_names_uniprotkb": "G kinase-anchoring protein 1; cGMP-dependent protein kinase-anchoring protein of 42 kDa", "protein_names_refseq": "42 kD cGMP-dependent protein kinase anchoring protein; G kinase-anchoring protein 1; cGMP-dependent protein kinase anchoring protein; cGMP-dependent protein kinase-anchoring protein of 42 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:56278)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10671526;15028281;21183079;21750661;25586176;28528544;31318116", "class_list": "", "function": "Data show that cGMP-dependent kinase (cGK-Ialpha) knockdown partially rescued TNF-alpha-induced decrease in 42-kDa cGMP-dependent protein kinase-anchoring protein (GKAP42) and impairment of insulin signals., [RefSeq, PubMed]; Hese results suggest that a deficiency of GKAP1 in mouse testis could increase sperm production through a reduction of the spontaneous apoptosis of germ cells in the testis, possibly because of a change in the activity of the cGK-Ialpha pathway., [RefSeq, PubMed]; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUD8", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007165 signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JMB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17710-1", "uniprot_id": "HXK1_MOUSE", "mass": 108303.0, "length": 974, "protein_name": "Hexokinase-1", "gene_name": "Hk1", "organism": "Mouse", "refseq_name": "hexokinase-1 isoform HK1-sb", "refseq_ac": "NP_034568", "gene_names_uniprotkb": "Hk1", "gene_names_refseq": "Hk-1; Hk1-s; Hk1; dea; mHk1-s", "protein_names_uniprotkb": "Hexokinase-1; 2.7.1.1; HK I; Hexokinase type I; Hexokinase, tumor isozyme", "protein_names_refseq": "HK I; downeast anemia; hexokinase type I; hexokinase, tumor isozyme; hexokinase-1 isoform HK1-sb", "tax_id": 10090, "disease": "congenital nonspherocytic hemolytic anemia 5 (Disease Ontology:DOID:0051006); retinitis pigmentosa 79 (Disease Ontology:DOID:0061108); Charcot-Marie-Tooth disease type 4G (Disease Ontology:DOID:0110196); retinitis pigmentosa (Disease Ontology:DOID:10584); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); anemia (Disease Ontology:DOID:2355); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); glucose metabolism disease (Disease Ontology:DOID:4194); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15275)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10567428;19889946;21750661;23055941;2318862;25428506;27374331;29125738;30084848;31219806;31599954;33300544;34428180;36288343;37507081;37973885;40684658;8396993;9450953", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Hemokinin-1 is a mediator of chronic restraint stress-induced pain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PXQ3;Q61659;Q64476;Q64479", "ec_number_list": "2.7.1.1;2.7.1.-", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0042834 peptidoglycan binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005929 cilium;GO:0045121 membrane raft", "go_biological_process": "GO:0002931 response to ischemia;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P17710-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDR9-1", "uniprot_id": "DOCK6_MOUSE", "mass": 233267.0, "length": 2080, "protein_name": "Dedicator of cytokinesis protein 6", "gene_name": "Dock6", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 6 isoform 1", "refseq_ac": "NP_796004", "gene_names_uniprotkb": "Dock6; Kiaa1395", "gene_names_refseq": "2410095B20Rik; 4931431C02Rik; C330023D02Rik; Dock6; mKIAA1395", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 6", "protein_names_refseq": "dedicator of cytokinesis protein 6 isoform 1; dedicator of cytokinesis protein 6", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:319899); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-983231)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17196961;17242355;21183079;21750661;21820096;23462102;24129315;30084848;31219806;34428180;36084651", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases (By similarity). Through its activation of CDC42 and RAC1, regulates neurite outgrowth in an vitro differentiation system., [UniProtKB]; Dock6 is the GEF specific for both Rac1 and Cdc42 and may be one of physiological regulators of neurite outgrowth., [RefSeq, PubMed]; Phosphorylation status of Dock6 at Ser(1194) determines whether it promotes axon extension or branching in sensory neurons, revealing interplay between kinase and phosphatase action on a Rho-GEF during axon growth Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKQ0;Q3UM59;Q6PFY0;Q8BJS1;Q9D461", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VDR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RT24-1", "uniprot_id": "CENPE_MOUSE", "mass": 286525.0, "length": 2474, "protein_name": "Centromere-associated protein E", "gene_name": "Cenpe", "organism": "Mouse", "refseq_name": "centromere-associated protein E", "refseq_ac": "NP_776123", "gene_names_uniprotkb": "Cenpe", "gene_names_refseq": "312kDa; C530022J18; CENP-E; Cenpe; Kif10", "protein_names_uniprotkb": "Centromere-associated protein E; CENP-E; Centromere protein E; KIF10; Kinesin superfamily protein 10; Motor domain of KIF10", "protein_names_refseq": "N-7 kinesin; centromere autoantigen E; centromere-associated protein E; centromeric protein E; kinesin 10; kinesin superfamily protein 10; motor domain of KIF10", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 13 (Disease Ontology:DOID:0070283)", "pathway": " (mmu:229841); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-6811434); (R-MMU-68877); (R-MMU-9648025); (R-MMU-983189)", "pathway_count": 11, "publication_count": 20, "publication_id_list": "12361599;12925705;18299400;21750661;21952136;22872234;25428506;25605945;30084848;31219806;33649389;34203471;34418053;34428180;35037651;35680098;35820727;37828378;40885482;9275178", "class_list": "", "function": "Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In Vivo Inhibition, Immunofluorescence and Flow Cytometry. Publication Status: Online-Only, [RefSeq, PubMed]; Kinesin-7 CENP-E is essential for chromosome alignment and spindle assembly of mouse spermatocytes., [RefSeq, PubMed]; Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated. Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends. Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (By similarity). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:12925705). The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC (PubMed:12361599). Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (PubMed:12925705)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35059;Q3KQQ6;Q3V044;Q6PD00;Q7TPX4;Q80YB4;Q8BWX6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0003777 microtubule motor activity;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0005634 nucleus;GO:0005874 microtubule;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051382 kinetochore assembly;GO:0051984 positive regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q6RT24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64317-1", "uniprot_id": "DLX1_MOUSE", "mass": 27309.0, "length": 255, "protein_name": "Homeobox protein DLX-1", "gene_name": "Dlx1", "organism": "Mouse", "refseq_name": "homeobox protein DLX-1", "refseq_ac": "NP_034183", "gene_names_uniprotkb": "Dlx1", "gene_names_refseq": "DII B; Dlx-1; Dlx1; Dlx", "protein_names_uniprotkb": "Homeobox protein DLX-1", "protein_names_refseq": "homeobox protein DLX-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13390)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1676488;21750661;21875655;30084848;8812481", "class_list": "", "function": "Plays a role as a transcriptional activator or repressor (PubMed:21875655). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1676488). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (PubMed:1676488)., [UniProtKB, UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0021879 forebrain neuron differentiation;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0021544 subpallium development;GO:0021893 cerebral cortex GABAergic interneuron fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R062-1", "uniprot_id": "GLYG_MOUSE", "mass": 37402.0, "length": 333, "protein_name": "Glycogenin-1", "gene_name": "Gyg1", "organism": "Mouse", "refseq_name": "glycogenin-1 isoform 2", "refseq_ac": "NP_038783", "gene_names_uniprotkb": "Gyg1; Gyg", "gene_names_refseq": "GN1; Gyg1; Gyg", "protein_names_uniprotkb": "Glycogenin-1; 2.4.1.186; GN-1; GN1", "protein_names_refseq": "glycogenin-1 isoform 2; glycogenin", "tax_id": 10090, "disease": "glycogen storage disease XV (Disease Ontology:DOID:0050579); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:27357); (R-MMU-3322077); (R-MMU-6798695); (R-MMU-70221)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10542328;18782850;21750661;24982189;26495903;26740625;36288343;37507081;39927985", "class_list": "glycogene;glycosyltransferase", "function": "Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Injection of recombinant adeno-associated virus-1 vector expressing glycogen synthase short hairpin ribonucleic acids into mice with type II glycogen storage disease leads to significant reduction in impaired glycogen accumulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWR9", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;3.2.1.20;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;2.4.1.18;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-;2.4.1.11", "go_molecular_function": "GO:0008466 glycogenin glucosyltransferase activity;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0005536 D-glucose binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1902494 catalytic complex", "go_biological_process": "GO:0005978 glycogen biosynthetic process;GO:0160249 glycogen biosynthetic process via UDP-glucose", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R062-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7X8-1", "uniprot_id": "GGCT_MOUSE", "mass": 21166.0, "length": 188, "protein_name": "Gamma-glutamylcyclotransferase", "gene_name": "Ggct", "organism": "Mouse", "refseq_name": "gamma-glutamylcyclotransferase", "refseq_ac": "NP_080913", "gene_names_uniprotkb": "Ggct", "gene_names_refseq": "A030007L17Rik; Gctg; Ggct; Ggc", "protein_names_uniprotkb": "Gamma-glutamylcyclotransferase; 4.3.2.9", "protein_names_refseq": "gamma-glutamylcyclotransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:110175); (R-MMU-174403)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;34409610;35820727;39191500", "class_list": "", "function": "Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis., [UniProtKB, UniProtKB]; Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by gamma-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells., [RefSeq, PubMed]; Ggct (gamma-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URJ2;Q66JQ5", "ec_number_list": "4.3.2.9", "go_molecular_function": "GO:0003839 gamma-glutamylcyclotransferase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001836 release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D7X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89033-1", "uniprot_id": "CDC6_MOUSE", "mass": 62614.0, "length": 562, "protein_name": "DNA replication factor CDC6", "gene_name": "Cdc6", "organism": "Mouse", "refseq_name": "cell division control protein 6 homolog isoform b", "refseq_ac": "NP_001020950", "gene_names_uniprotkb": "Cdc6", "gene_names_refseq": "CDC18L; Cdc6; p62(cdc6)", "protein_names_uniprotkb": "DNA replication factor CDC6; CDC6-related protein; Cell division control protein 6 homolog; p62(cdc6)", "protein_names_refseq": "CDC6-related protein; cell division control protein 6 homolog isoform b; cell division control protein 6 homolog; cell division cycle 6 homolog", "tax_id": 10090, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 5 (Disease Ontology:DOID:0080516)", "pathway": " (mmu:23834); (R-MMU-176187); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962); (R-MMU-69017)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "21183079;21750661;31219806;35236105;9774682", "class_list": "", "function": "Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMD0;Q8C3S5;Q9CZT0", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0051984 positive regulation of chromosome segregation;GO:1904385 cellular response to angiotensin;GO:0051301 cell division;GO:1904117 cellular response to vasopressin;GO:0048146 positive regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O89033-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIQ7-1", "uniprot_id": "DOCK3_MOUSE", "mass": 232910.0, "length": 2027, "protein_name": "Dedicator of cytokinesis protein 3", "gene_name": "Dock3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dock3; Moca", "gene_names_refseq": "", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 3; Modifier of cell adhesion; PBP; PS binding protein; Presenilin-binding protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:208869); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9032759); (R-MMU-983231)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10854253;12093789;19129390;21183079;21750661;30084848;33300544;34428180;40885482", "class_list": "", "function": "Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CIQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06537-1", "uniprot_id": "GCR_MOUSE", "mass": 87164.0, "length": 792, "protein_name": "Glucocorticoid receptor", "gene_name": "Nr3c1", "organism": "Mouse", "refseq_name": "glucocorticoid receptor", "refseq_ac": "NP_032199", "gene_names_uniprotkb": "Nr3c1; Grl1; Grl", "gene_names_refseq": "GR; Grl-1; Grl1; Nr3c1", "protein_names_uniprotkb": "Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1", "protein_names_refseq": "glucocorticoid receptor 1; glucocorticoid receptor subtype P; glucocorticoid receptor", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); lupus nephritis (Disease Ontology:DOID:0080162); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); lipoid nephrosis (Disease Ontology:DOID:10966); opioid abuse (Disease Ontology:DOID:11206); polycystic ovary syndrome (Disease Ontology:DOID:11612); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic neuropathy (Disease Ontology:DOID:14183); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); mood disorder (Disease Ontology:DOID:3324); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); primary hyperaldosteronism (Disease Ontology:DOID:446); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767); end stage renal disease (Disease Ontology:DOID:783); cocaine abuse (Disease Ontology:DOID:809); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); anorexia nervosa (Disease Ontology:DOID:8689); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14815); (R-MMU-3371497); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 4, "publication_count": 39, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;10678832;10848625;11278753;11435610;11555652;11751894;12949501;15037546;17012242;2019585;20660300;21183079;21750661;21994940;22170608;22517741;24129315;24736997;25153642;25676786;25847991;2702670;27686098;28135057;28751364;2911477;30698747;32782141;32848054;35822049;36852467;3780669;40021952;40885482;9195923;9528750;9742105", "class_list": "", "function": "Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity). Loses this transcription modulator function on its own (By similarity). Has no hormone-binding activity (PubMed:20660300). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity). Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity)., [UniProtKB, PubMed, UniProtKB]; Has transcriptional activation and repression activity (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (PubMed:21994940)., [UniProtKB, PubMed, UniProtKB, PubMed]; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 50, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E0ZPU5;E9PUR6;E9PYV1;Q06VW2;Q3U126;Q3U2M7;Q61628;Q61629", "ec_number_list": "", "go_molecular_function": "GO:0004883 nuclear glucocorticoid receptor activity;GO:0034056 estrogen response element binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0046685 response to arsenic-containing substance;GO:0048708 astrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P06537-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VGT2-1", "uniprot_id": "GLI2_MOUSE", "mass": 165031.0, "length": 1544, "protein_name": "Transcription activator GLI2", "gene_name": "Gli2", "organism": "Mouse", "refseq_name": "zinc finger protein GLI2", "refseq_ac": "NP_001074594", "gene_names_uniprotkb": "Gli2", "gene_names_refseq": "Gli2", "protein_names_uniprotkb": "Transcription activator GLI2", "protein_names_refseq": "Tax helper protein; zinc finger protein GLI2", "tax_id": 10090, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); spina bifida (Disease Ontology:DOID:0080016); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); Culler-Jones syndrome (Disease Ontology:DOID:0080328); holoprosencephaly 9 (Disease Ontology:DOID:0110873); biliary atresia (Disease Ontology:DOID:13608)", "pathway": " (mmu:14633); (R-MMU-5610787); (R-MMU-5632684)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10433919;10725236;10806483;11238441;16611981;16880529;17283082;19131326;20956384;21750661;22007132;23034632;25644602;25808752;26565916;31279575;35969743;38096226;38261656;40141354;9006072;9636069;9655799;9731531", "class_list": "", "function": "Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in skeleton development (PubMed:10806483, PubMed:16611981, PubMed:16880529, PubMed:22007132, PubMed:9006072, PubMed:9655799, PubMed:9731531). Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA-3' to activate or repress the expression of target genes (By similarity). Functions both as a transcriptional activator and repressor: the full-length GLI2 form (Transcription activator GLI2) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI2R, which is generated in absence of smoothened, acts as a transcription repressor (PubMed:10433919, PubMed:10806483). The transcriptional activator form constitutes the major form of GLI2 (PubMed:16611981)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Transcription factor, which activates expression of target genes in response to smoothened (SMO) activation (PubMed:10806483, PubMed:16611981, PubMed:16880529). Constitutes a major form of GLI2, while the transcription repressor form (GLI2R) plays a minor role (PubMed:16611981)., [UniProtKB, PubMed, PubMed, PubMed]; Transcription repressor, which inhibits expression of target genes in the absence of smoothened (SMO) signaling (PubMed:10433919). Generated by proteolytic processing of the full-length GLI2 form in the absence of hedgehog (DHH, IHH or SHH), when SMO transducer is inhibited (By similarity). Constitutes a minor form of GLI2, while the transcription activator GLI2 form plays a major role in smoothened signaling (PubMed:10433919)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PYJ4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0007418 ventral midline development;GO:0007442 hindgut morphogenesis;GO:0009913 epidermal cell differentiation;GO:0021696 cerebellar cortex morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q0VGT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M54-1", "uniprot_id": "CDCA3_MOUSE", "mass": 28708.0, "length": 266, "protein_name": "Cell division cycle-associated protein 3", "gene_name": "Cdca3", "organism": "Mouse", "refseq_name": "cell division cycle-associated protein 3", "refseq_ac": "NP_038566", "gene_names_uniprotkb": "Cdca3; C8; Grcc8; Tome1", "gene_names_refseq": "2410005A12Rik; C8; Cdca3; Grcc8; Tome-1", "protein_names_uniprotkb": "Cell division cycle-associated protein 3; Gene-rich cluster protein C8; TOME-1; Trigger of mitotic entry protein 1", "protein_names_refseq": "cell division cycle-associated protein 3; gene rich cluster, C8; gene-rich cluster protein C8; trigger of mitotic entry 1; trigger of mitotic entry protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14793)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12679038;15733861;19144319;21183079;21750661;9445485", "class_list": "", "function": "A repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site, and mutations within this element diminished the cell-cycle-dependent transcriptional regulation of Tome-1, [RefSeq, PubMed]; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88837;Q8R2V1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99M54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11352-1", "uniprot_id": "GPX1_MOUSE", "mass": 22329.0, "length": 201, "protein_name": "Glutathione peroxidase 1", "gene_name": "Gpx1", "organism": "Mouse", "refseq_name": "glutathione peroxidase 1 isoform 2", "refseq_ac": "NP_001316456", "gene_names_uniprotkb": "Gpx1", "gene_names_refseq": "CGPx; GPx-1; GSHPx-1; Gpx1; Gpx", "protein_names_uniprotkb": "Glutathione peroxidase 1; 1.11.1.12; 1.11.1.9; Cellular glutathione peroxidase; GPx-1; GSHPx-1; Phospholipid-hydroperoxide glutathione peroxidase GPX1; Selenium-dependent glutathione peroxidase 1", "protein_names_refseq": "cellular glutathione peroxidase; glutathione peroxidase 1 isoform 2; phospholipid-hydroperoxide glutathione peroxidase GPX1; selenium-dependent glutathione peroxidase 1", "tax_id": 10090, "disease": "Keshan disease (Disease Ontology:DOID:0050083); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); myeloid neoplasm (Disease Ontology:DOID:0070004); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); iron deficiency anemia (Disease Ontology:DOID:11758); nephrotic syndrome (Disease Ontology:DOID:1184); leukemia (Disease Ontology:DOID:1240); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); calcinosis (Disease Ontology:DOID:182); colon cancer (Disease Ontology:DOID:219); anemia (Disease Ontology:DOID:2355); nephrosis (Disease Ontology:DOID:2527); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); hairy cell leukemia (Disease Ontology:DOID:285); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); coronary artery disease (Disease Ontology:DOID:3393); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); Crohn's disease (Disease Ontology:DOID:8778); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14775); (R-MMU-2142712); (R-MMU-2142770); (R-MMU-3299685)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10754271;17242355;17503775;21420488;21750661;23576753;23806337;2771650;30084848;3015592;32358195;34428180;36608588;37453647;9126277;9195979;9712879", "class_list": "", "function": "Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:10754271, PubMed:21420488, PubMed:36608588, PubMed:9126277, PubMed:9195979, PubMed:9712879). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:10754271, PubMed:21420488, PubMed:36608588, PubMed:9126277, PubMed:9195979, PubMed:9712879). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:9195979)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 49, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P12079;Q544W3;Q5RJH8;Q9CR54", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.11.1.12;1.11.1.9;5.3.3.-;1.11.1.27;1.16.3.1;1.16.3.4;2.5.1.-;5.3.99.3", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:1990782 protein tyrosine kinase binding;GO:0004601 peroxidase activity;GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0097413 Lewy body", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0051702 biological process involved in interaction with symbiont;GO:0009609 response to symbiotic bacterium;GO:0001659 temperature homeostasis;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P11352-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P5F9-1", "uniprot_id": "XPO1_MOUSE", "mass": 123093.0, "length": 1071, "protein_name": "Exportin-1", "gene_name": "Xpo1", "organism": "Mouse", "refseq_name": "exportin-1", "refseq_ac": "NP_001399335", "gene_names_uniprotkb": "Xpo1; Crm1", "gene_names_refseq": "Crm1; Exp1; Xpo1", "protein_names_uniprotkb": "Exportin-1; Chromosome region maintenance 1 protein homolog; Exp1", "protein_names_refseq": "chromosome region maintenance 1 protein homolog; exportin 1, CRM1 homolog; exportin-1", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); extrahepatic bile duct carcinoma (Disease Ontology:DOID:4682); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:103573); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3769402); (R-MMU-450520); (R-MMU-5663220); (R-MMU-5687128); (R-MMU-68877); (R-MMU-69273); (R-MMU-9634638); (R-MMU-9648025); (R-MMU-9707616); (R-MMU-9856649)", "pathway_count": 15, "publication_count": 25, "publication_id_list": "10786834;18250455;18299400;20173027;20921223;21750661;23806337;25428506;25428507;25605945;28528544;30084848;30779550;31219806;33300544;33649389;34428180;34887587;35820727;36037515;36087493;37097386;37507081;37828378;39627609", "class_list": "", "function": "Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations., [RefSeq, PubMed]; Hydrocortisone alleviates sepsis-induced acute kidney injury through HSF-1-mediated transcriptional suppression of XPO1., [RefSeq, PubMed]; Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity)., [UniProtKB, PubMed]; Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0071401 cellular response to triglyceride;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006406 mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q6P5F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D824-1", "uniprot_id": "FIP1_MOUSE", "mass": 64959.0, "length": 581, "protein_name": "Pre-mRNA 3'-end-processing factor FIP1", "gene_name": "Fip1l1", "organism": "Mouse", "refseq_name": "pre-mRNA 3'-end-processing factor FIP1 isoform 1", "refseq_ac": "NP_001153045", "gene_names_uniprotkb": "Fip1l1", "gene_names_refseq": "1300019H17Rik; Fip1l1; Rje", "protein_names_uniprotkb": "Pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1 protein", "protein_names_refseq": "FIP1 like 1; FIP1-like 1 protein; pre-mRNA 3'-end-processing factor FIP1 isoform 1; pre-mRNA 3'-end-processing factor FIP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66899); (R-MMU-159231); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "16690743;17242355;19144319;19224921;21183079;21750661;22517741;22645316;25605945;30059200;30084848;30779550;32848054;34428180;34887587;35822049;36852467;40021952;40885482;40997131", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity)., [UniProtKB]; FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWX7;Q99LH0;Q9DBB2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0031124 mRNA 3'-end processing;GO:0031440 regulation of mRNA 3'-end processing;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9D824-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39689-1", "uniprot_id": "CDN1A_MOUSE", "mass": 17785.0, "length": 159, "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "Cdkn1a", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase inhibitor 1", "refseq_ac": "NP_001104569", "gene_names_uniprotkb": "Cdkn1a; Cip1; Waf1", "gene_names_refseq": "CAP20; CDKI; CIP1; Cdkn1a; Cdkn1; P21; SDI1; Waf1; mda6; p21Cip1; p21WAF", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein; p21", "protein_names_refseq": "CDK-interacting protein 1; cyclin-dependent kinase inhibitor 1; melanoma differentiation-associated protein", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); prostate cancer (Disease Ontology:DOID:10283); primary open angle glaucoma (Disease Ontology:DOID:1070); renal hypertension (Disease Ontology:DOID:1073); cholesteatoma of middle ear (Disease Ontology:DOID:10964); lipoid nephrosis (Disease Ontology:DOID:10966); sarcoidosis (Disease Ontology:DOID:11335); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); primary biliary cholangitis (Disease Ontology:DOID:12236); acoustic neuroma (Disease Ontology:DOID:12689); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); papilloma (Disease Ontology:DOID:2615); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); high grade glioma (Disease Ontology:DOID:3070); serous cystadenocarcinoma (Disease Ontology:DOID:3114); inverted papilloma (Disease Ontology:DOID:3179); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); pancreatic carcinoma (Disease Ontology:DOID:4905); stomach carcinoma (Disease Ontology:DOID:5517); sebaceous gland neoplasm (Disease Ontology:DOID:5759); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); maxillary sinus squamous cell carcinoma (Disease Ontology:DOID:7910); retinal degeneration (Disease Ontology:DOID:8466); ulcerative colitis (Disease Ontology:DOID:8577); psoriasis (Disease Ontology:DOID:8893); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); liver benign neoplasm (Disease Ontology:DOID:916); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (mmu:12575); (R-MMU-187577); (R-MMU-198323); (R-MMU-2559582); (R-MMU-2559586); (R-MMU-6804116); (R-MMU-69202); (R-MMU-69231); (R-MMU-69563); (R-MMU-69656); (R-MMU-8852276); (R-MMU-9616222)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "15851482;20154723;20231440;23007395;25329316;36689330;37178686;7796420;8084607;8242752", "class_list": "", "function": "May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity)., [UniProtKB, PubMed, UniProtKB]; Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:37178686). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (PubMed:37178686). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (PubMed:36689330)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Tested the hypothesis that p21 down-regulation could functionally induce a regenerative response in an appendage of an otherwise nonregenerating mouse strain, [RefSeq, PubMed]; This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 42, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0070557 PCNA-p21 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:2000278 regulation of DNA biosynthetic process;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39689-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62962-1", "uniprot_id": "PROF1_MOUSE", "mass": 14957.0, "length": 140, "protein_name": "Profilin-1", "gene_name": "Pfn1", "organism": "Mouse", "refseq_name": "profilin-1", "refseq_ac": "NP_035202", "gene_names_uniprotkb": "Pfn1", "gene_names_refseq": "Pfn1; Pfn", "protein_names_uniprotkb": "Profilin-1; Profilin I", "protein_names_refseq": "actin binding protein; profilin I; profilin-1", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 18 (Disease Ontology:DOID:0060209); pancreatic cancer (Disease Ontology:DOID:1793); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920)", "pathway": " (mmu:18643); (R-MMU-376176); (R-MMU-4086400); (R-MMU-5663220)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;16075062;21750661;23000962;25428506;26740625;2717414;32152506;33725478;34428180;37451478;37453647;37507081;37828378;37847555;38722279;39627609", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules., [RefSeq, PubMed]; Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P10924", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005102 signaling receptor binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0032233 positive regulation of actin filament bundle assembly;GO:0008064 regulation of actin polymerization or depolymerization;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P62962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08585-1", "uniprot_id": "CLCA_MOUSE", "mass": 25604.0, "length": 235, "protein_name": "Clathrin light chain A", "gene_name": "Clta", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Clta", "gene_names_refseq": "", "protein_names_uniprotkb": "Clathrin light chain A; Lca", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-177504); (R-MMU-190873); (R-MMU-196025); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722); (R-MMU-437239); (R-MMU-5099900); (R-MMU-5140745); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8866427); (R-MMU-8964038)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "21183079;21750661;23806337;25605945;30779550;34203471;34428180;36288343;37453647;37828378", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0042277 peptide binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030118 clathrin coat;GO:0030125 clathrin vesicle coat;GO:0098835 presynaptic endocytic zone membrane;GO:0005768 endosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0051301 cell division;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08585-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08796-1", "uniprot_id": "EF2K_MOUSE", "mass": 81739.0, "length": 724, "protein_name": "Eukaryotic elongation factor 2 kinase", "gene_name": "Eef2k", "organism": "Mouse", "refseq_name": "eukaryotic elongation factor 2 kinase isoform a", "refseq_ac": "NP_001254639", "gene_names_uniprotkb": "Eef2k", "gene_names_refseq": "Eef2k; eEF-2K", "protein_names_uniprotkb": "Eukaryotic elongation factor 2 kinase; 2.7.11.20; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K", "protein_names_refseq": "calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eukaroytic elongation factor 2 kinase; eukaryotic elongation factor 2 kinase isoform a", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:13631); (R-MMU-166208)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12213630;17242355;17991718;20045915;21183079;21540332;21750661;22645316;26495903;28955910;31219806;34428180;34815424;37875468;38320351;9144159", "class_list": "", "function": "Control of CD4[+] T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase. Publication Status: Online-Only, [RefSeq, PubMed]; During late embryonic and early postnatal stages, elongation factor 2 kinase is up-regulated in the cerebral cortex and hippocampal pyramidal cell layer., [RefSeq, PubMed]; Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma., [RefSeq, PubMed]; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation (PubMed:34815424, PubMed:9144159). Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive (PubMed:34815424, PubMed:9144159). In turn, the rate of protein synthesis is reduced (PubMed:34815424, PubMed:9144159)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.20;2.7.11.1", "go_molecular_function": "GO:0004686 elongation factor-2 kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0008135 translation factor activity, RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:1990637 response to prolactin;GO:0002931 response to ischemia;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O08796-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXK7-1", "uniprot_id": "DPP10_MOUSE", "mass": 90827.0, "length": 797, "protein_name": "Inactive dipeptidyl peptidase 10", "gene_name": "Dpp10", "organism": "Mouse", "refseq_name": "inactive dipeptidyl peptidase 10 isoform 1", "refseq_ac": "NP_950186", "gene_names_uniprotkb": "Dpp10", "gene_names_refseq": "6430601K09Rik; DPP X; Dpp10; Dprp3", "protein_names_uniprotkb": "Inactive dipeptidyl peptidase 10; DPP X; Dipeptidyl peptidase X", "protein_names_refseq": "dipeptidyl peptidase X; inactive dipeptidyl peptidase 10 isoform 1; inactive dipeptidyl peptidase 10", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:269109)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14566338;15671030;21750661;22311982;30084848;30899004;33300544;35820727;40885482", "class_list": "glycogene", "function": "Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:22311982). Has no dipeptidyl aminopeptidase activity (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6P554;Q8K1H0", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis;GO:0072659 protein localization to plasma membrane;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q6NXK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Y83-1", "uniprot_id": "DIXC1_MOUSE", "mass": 80215.0, "length": 711, "protein_name": "Dixin", "gene_name": "Dixdc1", "organism": "Mouse", "refseq_name": "dixin isoform 2", "refseq_ac": "NP_001297998", "gene_names_uniprotkb": "Dixdc1; Ccd1; Kiaa1735", "gene_names_refseq": "4930563F16Rik; Ccd1Aalpha1L; Ccd1Abeta1L; Ccd1BalphaL; Ccd1BbetaL; Ccd1CL; Ccd1; Dixdc1; mKIAA1735", "protein_names_uniprotkb": "Dixin; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1", "protein_names_refseq": "DIX domain-containing protein 1; coiled-coil protein DIX1; coiled-coil-DIX1; dixin isoform 2; dixin", "tax_id": 10090, "disease": "", "pathway": " (mmu:330938)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12792787;15262978;15857680;16378754;21183079;21750661;35144597", "class_list": "", "function": "DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; DIXDC1 encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain, [RefSeq, PubMed]; Mouse Ccd1 functions as a positive regulator of the Wnt/beta-catenin pathway. Furthermore, Ccd1 is highly expressed and co-localized with Wnt signaling molecules in the embryonic and adult brain., [RefSeq, PubMed]; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPF4;Q3UQ90;Q5DPZ2;Q5DPZ3;Q5DPZ4;Q5DPZ6;Q6ZPJ2;Q8C467;Q8R1C1", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0043015 gamma-tubulin binding;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0021799 cerebral cortex radially oriented cell migration;GO:0021869 forebrain ventricular zone progenitor cell division;GO:0032956 regulation of actin cytoskeleton organization;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80Y83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1ERP8-1", "uniprot_id": "CLM9_MOUSE", "mass": 36756.0, "length": 331, "protein_name": "CMRF35-like molecule 9", "gene_name": "Cd300lg", "organism": "Mouse", "refseq_name": "CMRF35-like molecule 9 isoform 1 precursor", "refseq_ac": "NP_001154183", "gene_names_uniprotkb": "Cd300lg; Clm9; D11Ertd736e", "gene_names_refseq": "2310016B05Rik; Cd300lg; Clm9; D11Ertd736e", "protein_names_uniprotkb": "CMRF35-like molecule 9; CD300 antigen-like family member G; CLM-9; Nepmucin", "protein_names_refseq": "CD300 antigen like family member G; CLM-9; CMRF-35-like molecule-9; CMRF35-like molecule 9 isoform 1 precursor; CMRF35-like molecule 9; nepmucin", "tax_id": 10090, "disease": "", "pathway": " (mmu:52685); (R-MMU-198933)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14662855;16754720;16876123;18675811;21750661;24376728", "class_list": "", "function": "Nepmucin may serve as a dual-functioning in peripheral node addressin in endothial venules mediating both lymphocyte rolling and binding via different functional domains., [RefSeq, PubMed]; Nepmucin/CD300LG expression in microvascular endothelial cells Publication Status: Online-Only, [RefSeq, PubMed]; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte., [UniProtKB, PubMed, PubMed]; These results suggest that endothelial nepmucin promotes lymphocyte transendothelial migration using multiple adhesion pathways., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "A2A503;Q1ERP9;Q1ERQ0;Q3UU12;Q6SJP9;Q9D7B8", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001791 IgM binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0032585 multivesicular body membrane", "go_biological_process": "GO:0002414 immunoglobulin transcytosis in epithelial cells;GO:0007165 signal transduction;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q1ERP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51791-1", "uniprot_id": "CLCN3_MOUSE", "mass": 90812.0, "length": 818, "protein_name": "H(+)/Cl(-) exchange transporter 3", "gene_name": "Clcn3", "organism": "Mouse", "refseq_name": "H(+)/Cl(-) exchange transporter 3 isoform e", "refseq_ac": "NP_776299", "gene_names_uniprotkb": "Clcn3; Clc3", "gene_names_refseq": "Clc3; Clcn3", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 3; Chloride channel protein 3; Chloride transporter ClC-3; ClC-3", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 3 isoform e; chloride channel 3; chloride channel protein 3; chloride transporter ClC-3; clC-3; h(+)/Cl(-) exchange transporter 3", "tax_id": 10090, "disease": "Dent disease (Disease Ontology:DOID:0050699); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (mmu:12725)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15504734;16222710;18923035;21750661;24603049;25428506;26342074;28972156;31219806;34428180;35792204;36210013;36536096;7665160;9678416", "class_list": "", "function": "De novo CLCN3 variants affecting Gly327 cause severe neurodevelopmental syndrome with brain structural abnormalities., [RefSeq, PubMed]; Knockdown of CLC-3 may improve cognitive impairment caused by diabetic encephalopathy., [RefSeq, PubMed]; May influence large dense-core vesicle exocytosis in adrenal chromaffin cells., [UniProtKB]; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF45;Q8K4X0;Q8K4X1", "ec_number_list": "", "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005216 monoatomic ion channel activity;GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0006911 phagocytosis, engulfment;GO:0008344 adult locomotory behavior;GO:0070050 neuron cellular homeostasis;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P51791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQK0-1", "uniprot_id": "CCNT2_MOUSE", "mass": 80252.0, "length": 723, "protein_name": "Cyclin-T2", "gene_name": "Ccnt2", "organism": "Mouse", "refseq_name": "cyclin-T2", "refseq_ac": "NP_082675", "gene_names_uniprotkb": "Ccnt2", "gene_names_refseq": "2900041I18Rik; Ccnt2; CycT2a; CycT2b; CycT2", "protein_names_uniprotkb": "Cyclin-T2; CycT2", "protein_names_refseq": "cyclin T2a; cyclin T2b; cyclin-T2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72949); (R-MMU-112382); (R-MMU-2173796); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6807505); (R-MMU-75955)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "12037670;16245309;19364821;21183079;21740905;23060074;25428506;31219806;34428180;34678516;40021952", "class_list": "", "function": "Activation of MyoD-dependent transcription by cdk9/cyclin T2, [RefSeq, PubMed]; Both isoforms of Cyclin T2 are able to activate the myogenic program but Cyclin T2b has a predominant role, in particular during the latest stages., [RefSeq, PubMed]; MiR-15a inhibited muscle differentiation at least in part by targeting Ccnt2; roles in spermatogenesis., [RefSeq, PubMed]; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA (By similarity). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (PubMed:12037670, PubMed:16245309, PubMed:23060074). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (By similarity). Involved in early embryo development (PubMed:19364821)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "K4N0L9;K4N2S3", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0070063 RNA polymerase binding;GO:0001223 transcription coactivator binding;GO:0097322 7SK snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0019085 early viral transcription;GO:0019086 late viral transcription;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7TQK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28033-1", "uniprot_id": "CEBPB_MOUSE", "mass": 31446.0, "length": 296, "protein_name": "CCAAT/enhancer-binding protein beta", "gene_name": "Cebpb", "organism": "Mouse", "refseq_name": "CCAAT/enhancer-binding protein beta isoform b", "refseq_ac": "NP_001274667", "gene_names_uniprotkb": "Cebpb", "gene_names_refseq": "C/EBPbeta; CRP2; Cebpb; IL-6DBP; LAP; LIP; NF-IL6; NF-M; Nfil6", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein beta; AGP/EBP; C/EBP beta; IL-6DBP; Interleukin-6-dependent-binding protein; LAP; Liver-enriched transcriptional activator", "protein_names_refseq": "AGP/EBP; C/EBP BETA; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta isoform b; interleukin-6-dependent-binding protein; liver-enriched transcriptional activator; nuclear protein Il6", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); osteochondrodysplasia (Disease Ontology:DOID:2256); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:12608); (R-MMU-2559582)", "pathway_count": 2, "publication_count": 51, "publication_id_list": "10635333;11018027;11684016;11726507;11756662;11792321;12213825;1314426;15314150;15367685;15509779;15644333;15860545;15879117;15985551;16585579;1701020;17301242;17433708;17601773;17911624;1840554;18486321;18647749;19015024;19324970;19440205;19478079;19641492;19940121;20111005;20194620;20730378;21183079;21292824;21602272;22245780;22355693;24061474;24216764;25428506;25451943;27923061;28135057;31219806;34428180;40997131;7598808;9303532;9727068;9742105", "class_list": "", "function": "Acts as a dominant negative through heterodimerization with isoform 2 (By similarity). Promotes osteoblast differentiation and osteoclastogenesis (PubMed:19440205)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing., [UniProtKB, PubMed]; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16585579, PubMed:17911624, PubMed:18486321, PubMed:20111005). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:10635333, PubMed:17301242, PubMed:17601773, PubMed:19478079, PubMed:24061474, PubMed:24216764, PubMed:9727068). The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA (PubMed:15509779). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:10635333, PubMed:16585579, PubMed:9727068). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (PubMed:17911624). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:15985551, PubMed:17301242, PubMed:17601773, PubMed:20194620). Essential for female reproduction because of a critical role in ovarian follicle development (PubMed:9303532). Restricts osteoclastogenesis (PubMed:19440205). Together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0036488 CHOP-C/EBP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0002432 granuloma formation;GO:0035711 T-helper 1 cell activation;GO:0072574 hepatocyte proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P28033-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53568-1", "uniprot_id": "CEBPG_MOUSE", "mass": 16400.0, "length": 150, "protein_name": "CCAAT/enhancer-binding protein gamma", "gene_name": "Cebpg", "organism": "Mouse", "refseq_name": "CCAAT/enhancer-binding protein gamma", "refseq_ac": "NP_034014", "gene_names_uniprotkb": "Cebpg", "gene_names_refseq": "C/EBP[g]; C/EBPgamma; Cebpg; GPE1-BP; Gpe1bp; Ig/EBP", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein gamma; C/EBP gamma; GPE1-BP; GPE1-binding protein; Granulocyte colony-stimulating factor promoter element 1-binding protein; IG/EBP-1; Immunoglobulin enhancer-binding protein 1", "protein_names_refseq": "CCAAT/enhancer binding protein (C/EBP), gamma; CCAAT/enhancer-binding protein gamma; G-CSF promoter element 1 binding protein; GPE1-BP (C/EBP gamma); GPE1-binding protein; IG/EBP-1; c/EBP gamma; granulocyte colony-stimulating factor promoter element 1-binding protein; immunoglobulin enhancer-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12611)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1709121;2121606;21602272;29567783;31309319;35801910;37210575", "class_list": "", "function": "CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Specific deletion of Cebpg in the murine hematopoietic system did not alter hematopoietic stem and progenitor cell properties, their ability to commit to the myeloid lineage, and produce granulocytes in normal and stress conditions., [RefSeq, PubMed]; Systemic approaches using single cell transcriptome reveal that C/EBPgamma regulates autophagy under amino acid starved condition., [RefSeq, PubMed]; The results suggest the role of C/EBPgamma on ATF5 (activating transcription factor 5)-regulated vomeronasal sensory neurons differentiation in early postnatal development., [RefSeq, PubMed]; Transcription factor that binds to the promoter and the enhancer regions of target genes (PubMed:21602272). Binds to the promoter and the enhancer of the immunoglobulin heavy chain (PubMed:2121606). Binds to GPE1, a cis-acting element in the G-CSF gene promoter (PubMed:1709121). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044377 RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending;GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0044877 protein-containing complex binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0043353 enucleate erythrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53568-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SS90-1", "uniprot_id": "CG057_MOUSE", "mass": 32895.0, "length": 291, "protein_name": "Uncharacterized protein C7orf57 homolog", "gene_name": "Gm11992", "organism": "Mouse", "refseq_name": "uncharacterized protein C7orf57 homolog", "refseq_ac": "NP_001033017", "gene_names_uniprotkb": "Gm11992", "gene_names_refseq": "Gm11992", "protein_names_uniprotkb": "Uncharacterized protein C7orf57 homolog", "protein_names_refseq": "uncharacterized protein C7orf57 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:626870)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SS90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IRU5-1", "uniprot_id": "CLCB_MOUSE", "mass": 25172.0, "length": 229, "protein_name": "Clathrin light chain B", "gene_name": "Cltb", "organism": "Mouse", "refseq_name": "clathrin light chain B isoform a", "refseq_ac": "NP_001334441", "gene_names_uniprotkb": "Cltb", "gene_names_refseq": "2310046E19Rik; Cltb; lcb", "protein_names_uniprotkb": "Clathrin light chain B; Lcb", "protein_names_refseq": "clathrin light chain B isoform a; clathrin, light polypeptide (Lcb)", "tax_id": 10090, "disease": "", "pathway": " (mmu:74325); (R-MMU-190873); (R-MMU-196025); (R-MMU-432720); (R-MMU-5099900); (R-MMU-5140745); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "21750661;23806337;25428506;26495903;30084848;30779550;31209405;31599954;34428180;37923360", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB]; Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BR04;Q8CDX9;Q9CV35", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0042277 peptide binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0030118 clathrin coat;GO:0030125 clathrin vesicle coat;GO:0098835 presynaptic endocytic zone membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6IRU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BT07-1", "uniprot_id": "CEP55_MOUSE", "mass": 53930.0, "length": 462, "protein_name": "Centrosomal protein of 55 kDa", "gene_name": "Cep55", "organism": "Mouse", "refseq_name": "centrosomal protein of 55 kDa isoform 1", "refseq_ac": "NP_001157834", "gene_names_uniprotkb": "Cep55", "gene_names_refseq": "1200008O12Rik; 2700032M20Rik; Cep55", "protein_names_uniprotkb": "Centrosomal protein of 55 kDa; Cep55", "protein_names_refseq": "centrosomal protein of 55 kDa isoform 1; centrosomal protein of 55 kDa", "tax_id": 10090, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (Disease Ontology:DOID:0080327); hydranencephaly (Disease Ontology:DOID:4626)", "pathway": " (mmu:74107)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;20176808;20186884;21183079;26495903;36658310;37381005", "class_list": "", "function": "Alpha-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55., [RefSeq, PubMed]; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney., [UniProtKB, UniProtKB]; TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge., [RefSeq, PubMed]; The results suggest that Cep55 and pericentrin are required for the stable bridge between germ cells during spermatogenesis and spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2J0;Q8K2I8;Q8R2Y4;Q9DBZ8", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0032154 cleavage furrow;GO:0005814 centriole", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1904888 cranial skeletal system development;GO:0045184 establishment of protein localization;GO:0000281 mitotic cytokinesis;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BT07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WS0-1", "uniprot_id": "CISD1_MOUSE", "mass": 12097.0, "length": 108, "protein_name": "CDGSH iron-sulfur domain-containing protein 1", "gene_name": "Cisd1", "organism": "Mouse", "refseq_name": "CDGSH iron-sulfur domain-containing protein 1", "refseq_ac": "NP_598768", "gene_names_uniprotkb": "Cisd1; D10Ertd214e; Zcd1", "gene_names_refseq": "Cisd1; D10Ertd214e; Zcd1; mitoNEET", "protein_names_uniprotkb": "CDGSH iron-sulfur domain-containing protein 1; 2.6.1.3; Cysteine transaminase CISD1; MitoNEET", "protein_names_refseq": "CDGSH iron-sulfur domain-containing protein 1; cysteine transaminase CISD1; zinc finger, CDGSH-type domain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52637)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14570702;17376863;23576753;28528544;34428180;34509082;36288343;37507081;39927985", "class_list": "", "function": "CISD1 protects against atherosclerosis by suppressing lipid accumulation and inflammation via mediating Drp1., [RefSeq, PubMed]; L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (By similarity). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (By similarity). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (PubMed:17376863). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (By similarity)., [UniProtKB, UniProtKB, PubMed]; Mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates, [RefSeq, PubMed]; MitoNEET is located in mitochondrial fraction of adipocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2I3;Q8WUQ5", "ec_number_list": "2.6.1.1;2.6.1.3", "go_molecular_function": "GO:0005506 iron ion binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0047801 L-cysteine transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0032473 cytoplasmic side of mitochondrial outer membrane", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0010506 regulation of autophagy;GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91WS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z260-1", "uniprot_id": "CLD8_MOUSE", "mass": 24947.0, "length": 225, "protein_name": "Claudin-8", "gene_name": "Cldn8", "organism": "Mouse", "refseq_name": "claudin-8", "refseq_ac": "NP_061248", "gene_names_uniprotkb": "Cldn8", "gene_names_refseq": "Cldn8", "protein_names_uniprotkb": "Claudin-8", "protein_names_refseq": "claudin-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:54420)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10601346;20921420;25831548;32245797;9892664", "class_list": "", "function": "Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:20921420, PubMed:25831548). Cannot form tight junction strands on its own (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Interaction between Epithelial Sodium Channel gamma-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct., [RefSeq, PubMed]; This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a paracellular cation barrier. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016327 apicolateral plasma membrane", "go_biological_process": "GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0160184 paracellular transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6L5-1", "uniprot_id": "CGAS_MOUSE", "mass": 58194.0, "length": 507, "protein_name": "Cyclic GMP-AMP synthase", "gene_name": "Cgas", "organism": "Mouse", "refseq_name": "cyclic GMP-AMP synthase", "refseq_ac": "NP_775562", "gene_names_uniprotkb": "Cgas; E330016A19Rik; Mb21d1", "gene_names_refseq": "Cgas; E330016A19Rik; Mb21d1", "protein_names_uniprotkb": "Cyclic GMP-AMP synthase; 2'3'-cGAMP synthase; 2.7.7.86; Mab-21 domain-containing protein 1; cGAMP synthase; cGAS; m-cGAS", "protein_names_refseq": "2'3'-cGAMP synthase; Mab-21 domain containing 1; cGAMP synthase; cyclic GMP-AMP synthase; mab-21 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:214763)", "pathway_count": 1, "publication_count": 47, "publication_id_list": "21750661;23258413;23647843;23722158;23929945;23989956;24077100;24332030;24462292;25525874;26229117;26440888;26829768;27637147;28095500;28214358;28314590;28363908;28738408;28759028;28902841;28963528;29426904;29625897;29976794;30007416;30356214;30827685;30878284;31219806;31534008;31544964;31808743;31992625;32351706;32457395;32474700;32814054;32911480;32911481;32913000;33688080;35210392;35460603;38200309;38418882;39322678", "class_list": "", "function": "CGAS first catalyses the synthesis of a linear 2'-5'-linked dinucleotide, which is then subject to cGAS-dependent cyclization in a second step through a 3'-5' phosphodiester linkage; this ring structure defines a novel class of second messenger molecules, [RefSeq, PubMed]; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23647843, PubMed:23722158, PubMed:26829768, PubMed:28214358, PubMed:29426904, PubMed:29625897, PubMed:32814054). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:23258413, PubMed:23647843, PubMed:23722158, PubMed:26829768, PubMed:28214358). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:23722158, PubMed:28095500, PubMed:28314590, PubMed:28363908, PubMed:39322678). Preferentially binds long dsDNA (around 45 bp) and forms ladder-like networks that function cooperatively to stabilize individual cGAS-dsDNA complexes (PubMed:28902841). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:23722158, PubMed:28314590, PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:23258413, PubMed:23647843, PubMed:23722158). Also acts as an innate immune sensor of infection by retroviruses by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (By similarity). Also detects the presence of DNA from bacteria (By similarity). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100, PubMed:31992625). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229117). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (By similarity). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759028). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (PubMed:28759028). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (By similarity). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31808743, PubMed:32911480, PubMed:32911481, PubMed:32913000). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964, PubMed:35210392). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study shows that, upon dsDNA binding, cGAS is activated through conformational transitions, resulting in formation of a catalytically competent and accessible nucleotide-binding pocket for generation of c[G(2',5')pA(3',5')p]., [RefSeq, PubMed]; The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]; These results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP., [RefSeq, PubMed]; These results indicate that cGAS is an innate immune sensor of HIV and other retroviruses., [RefSeq, PubMed]; This study shows that cells from cGAS-deficient (cGas(-/-)) mice, including fibroblasts, macrophages, and dendritic cells, failed to produce type I interferons and other cytokines in response to DNA transfection or DNA virus infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 47, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULW3", "ec_number_list": "2.7.7.86", "go_molecular_function": "GO:0061501 2',3'-cyclic GMP-AMP synthase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0002221 pattern recognition receptor signaling pathway;GO:0002637 regulation of immunoglobulin production;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q8C6L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ62-1", "uniprot_id": "CEP97_MOUSE", "mass": 94641.0, "length": 856, "protein_name": "Centrosomal protein of 97 kDa", "gene_name": "Cep97", "organism": "Mouse", "refseq_name": "centrosomal protein of 97 kDa isoform 2", "refseq_ac": "NP_001152836", "gene_names_uniprotkb": "Cep97; Lrriq2", "gene_names_refseq": "2810403B08Rik; 4932439K18Rik; Cep97; E130116N02Rik; Lrriq2", "protein_names_uniprotkb": "Centrosomal protein of 97 kDa; Cep97; Leucine-rich repeat and IQ domain-containing protein 2", "protein_names_refseq": "centrosomal protein of 97 kDa isoform 2; centrosomal protein of 97 kDa; leucine-rich repeat and IQ domain-containing protein 2; leucine-rich repeats and IQ motif containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74201); (R-MMU-5620912); (R-MMU-9013424)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21183079;30375385;34428180;35301795;40885482", "class_list": "", "function": "Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome (By similarity)., [UniProtKB, UniProtKB]; ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL35", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0032991 protein-containing complex", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0030030 cell projection organization;GO:1901673 regulation of mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZ62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0G9-1", "uniprot_id": "CLD3_MOUSE", "mass": 23285.0, "length": 219, "protein_name": "Claudin-3", "gene_name": "Cldn3", "organism": "Mouse", "refseq_name": "claudin-3", "refseq_ac": "NP_034032", "gene_names_uniprotkb": "Cldn3; Cpetr2", "gene_names_refseq": "Cldn3; Cpetr2; mRVP1", "protein_names_uniprotkb": "Claudin-3; CPE-R 2; CPE-receptor 2; Clostridium perfringens enterotoxin receptor 2", "protein_names_refseq": "CPE-R 2; CPE-receptor 2; claudin-3; clostridium perfringens enterotoxin receptor 2", "tax_id": 10090, "disease": "peptic esophagitis (Disease Ontology:DOID:13976)", "pathway": " (mmu:12739)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10508613;10562289;10601346;17242355;24588076;25678664;34428180;39115555;9878248;9892664", "class_list": "", "function": "Absence of claudin-3 does not alter intestinal absorption of phosphate in mice., [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology. [provided by RefSeq, Aug 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X40", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0090559 regulation of membrane permeability;GO:0007155 cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z0G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0S6-1", "uniprot_id": "CLD10_MOUSE", "mass": 24695.0, "length": 231, "protein_name": "Claudin-10", "gene_name": "Cldn10", "organism": "Mouse", "refseq_name": "claudin-10 isoform a_i1", "refseq_ac": "NP_001153568", "gene_names_uniprotkb": "Cldn10; Cldn10a", "gene_names_refseq": "6720456I16Rik; Cldn10a; Cldn10b; Cldn10; D14Ertd728e", "protein_names_uniprotkb": "Claudin-10", "protein_names_refseq": "claudin 10B; claudin-10 isoform a_i1; claudin-10A", "tax_id": 10090, "disease": "", "pathway": " (mmu:58187)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14698084;16520537;16804102;17075866;19383724;20460438;22891322;26495903;28771254;35031570;38612818", "class_list": "", "function": "Claudin-10 Expression and the Gene Expression Pattern of Thick Ascending Limb Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Claudin-10 is expressed at the variety of epithelial tissues in the coclea of inner ear including Organ of Corti, stria vascularis, Reissner's membrane, and spiral limbus., [RefSeq, PubMed]; Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis., [UniProtKB, PubMed, PubMed, PubMed]; Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability., [UniProtKB, PubMed, PubMed, PubMed]; This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight unction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Six alternatively spliced transcript variants have been identified, which encode different isoforms with distinct electric charge of the first extracellular loop and with or without the fourth transmembrane region. These isoforms exhibit distinct localization and function in paracellular anion or cation permeability. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PVC8;E9PWP4;E9QMP1;Q8VC62;Q9CX57", "ec_number_list": "5.6.1.6;1.8.-.-;2.7.11.1;1.8.5.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070160 tight junction", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0043269 regulation of monoatomic ion transport;GO:0160184 paracellular transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z0S6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13864-1", "uniprot_id": "DNMT1_MOUSE", "mass": 183189.0, "length": 1620, "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "Dnmt1", "organism": "Mouse", "refseq_name": "DNA (cytosine-5)-methyltransferase 1 isoform 1", "refseq_ac": "NP_001186360", "gene_names_uniprotkb": "Dnmt1; Dnmt; Met1; Uim", "gene_names_refseq": "Cxxc9; Dnmt1o; Dnmt1; Dnmt; MCMT; MTase; Met-1; Met1; MommeD2; m.MmuI", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 1; 2.1.1.37; DNA MTase MmuI; DNA methyltransferase MmuI; Dnmt1; M.MmuI; MCMT; Met-1", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 1 isoform 1; DNA (cytosine-5)-methyltransferase 1; DNA MTase MmuI; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase MmuI", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autosomal dominant cerebellar ataxia, deafness and narcolepsy (Disease Ontology:DOID:0050968); hereditary sensory neuropathy type 1E (Disease Ontology:DOID:0070158); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Graves' disease (Disease Ontology:DOID:12361); lung cancer (Disease Ontology:DOID:1324); congenital heart disease (Disease Ontology:DOID:1682); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); choline deficiency disease (Disease Ontology:DOID:8456); chronic myeloid leukemia (Disease Ontology:DOID:8552); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:13433); (R-MMU-212300); (R-MMU-4655427)", "pathway_count": 3, "publication_count": 57, "publication_id_list": "10.1101/2023.09.13.557529;10615135;10715201;10888872;11063128;11290321;11399088;15550930;15634679;16085498;1628623;16357870;17242355;17371843;17576694;17893328;17965600;18299400;19144319;20173027;20192920;20484733;21163962;21183079;21268065;21518897;21750661;21952136;22323818;23806337;25428506;25605945;26065575;28528544;28842251;29053958;29237092;30084848;30779550;31219806;31599954;3210246;33649389;34203471;34428180;34887587;35820727;36210013;37828378;39627609;40155743;8898232;8917520;8940105;9211941;9449671;9830015", "class_list": "", "function": "DNA methyltransferase that methylates CpG residues (PubMed:11290321, PubMed:11399088, PubMed:17576694, PubMed:17893328, PubMed:22323818). Preferentially methylates hemimethylated DNA (PubMed:11399088, PubMed:17576694, PubMed:17893328, PubMed:22323818). Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance (PubMed:11399088, PubMed:17576694, PubMed:22323818). Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication (PubMed:11399088, PubMed:15550930, PubMed:17576694). It is responsible for maintaining methylation patterns established in development (PubMed:11399088, PubMed:17576694). DNA methylation is coordinated with methylation of histones (By similarity). Mediates transcriptional repression by direct binding to HDAC2 (By similarity). In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9 (By similarity). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (By similarity). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Data suggest that the biological functions of DNA methyltransferase 1 are exerted through the methylation of DNA., [RefSeq, PubMed]; Structure of DNMT1 composed of CXXC, tandem bromo-adjacent homology (BAH1/2), and methyltransferase domains bound to DNA-containing unmethylated CpG sites; studies identify an autoinhibitory mechanism of DNA methylation, [RefSeq, PubMed]; This enzyme is a target of DNA methylation in embryogenesis., [RefSeq, PubMed]; This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 28, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97413;Q80ZU3;Q9CSC6;Q9QXX6", "ec_number_list": "3.5.1.-;3.5.1.98;2.1.1.37;2.1.1.-;2.3.2.-;2.1.1.356;2.3.2.27;3.6.4.-", "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005657 replication fork;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043045 epigenetic programming of gene expression;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "P13864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54823-1", "uniprot_id": "DDX6_MOUSE", "mass": 54192.0, "length": 483, "protein_name": "Probable ATP-dependent RNA helicase DDX6", "gene_name": "Ddx6", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX6 isoform 1", "refseq_ac": "NP_001104296", "gene_names_uniprotkb": "Ddx6; Hlr2; Rck", "gene_names_refseq": "1110001P04Rik; C430015D01Rik; Ddx6; E230023J21Rik; HLR2; mRCK/P54; p54; rck", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX6; 3.6.4.13; ATP-dependent RNA helicase p54; DEAD box protein 6; Oncogene RCK homolog", "protein_names_refseq": "ATP-dependent RNA helicase p54; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 6; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 6; DEAD box protein 6; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6; oncogene RCK homolog; probable ATP-dependent RNA helicase DDX6 isoform 1; probable ATP-dependent RNA helicase DDX6", "tax_id": 10090, "disease": "", "pathway": " (mmu:13209); (R-MMU-430039)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10704462;18250455;18299400;20173027;20639877;21952136;25428506;25428507;25605945;26098573;26495903;26740625;28528544;30084848;30779550;33649389;34428180;34887587;35820727;37083226;37507081;37828378;8543178;9883581", "class_list": "", "function": "Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (By similarity). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). In the process of mRNA degradation, plays a role in mRNA decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54979;Q3UFI3;Q8BW68", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;3.6.1.62;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0097227 sperm annulus;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019074 viral RNA genome packaging;GO:0045665 negative regulation of neuron differentiation;GO:0017148 negative regulation of translation;GO:0019827 stem cell population maintenance;GO:0035278 miRNA-mediated gene silencing by inhibition of translation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P54823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q570Y9-1", "uniprot_id": "DPTOR_MOUSE", "mass": 46120.0, "length": 409, "protein_name": "DEP domain-containing mTOR-interacting protein", "gene_name": "Deptor", "organism": "Mouse", "refseq_name": "DEP domain-containing mTOR-interacting protein isoform b", "refseq_ac": "NP_001033026", "gene_names_uniprotkb": "Deptor; Depdc6; Kiaa4200", "gene_names_refseq": "Depdc6; Deptor", "protein_names_uniprotkb": "DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6", "protein_names_refseq": "DEP domain-containing mTOR-interacting protein isoform b; DEP domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:97998)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21607293;21750661;22883231;26795633;34428180;36535626;36548081", "class_list": "", "function": "DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis., [RefSeq, PubMed]; DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice., [RefSeq, PubMed]; Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR kinase substrates, 4E-BP1 and S6K1, and concomitantly increased protein synthesis., [RefSeq, PubMed]; Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity., [UniProtKB, UniProtKB]; The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UM00;Q3UT08", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0004860 protein kinase inhibitor activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0070300 phosphatidic acid binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0007186 G protein-coupled receptor signaling pathway;GO:0006469 negative regulation of protein kinase activity;GO:0010507 negative regulation of autophagy;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q570Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C147-1", "uniprot_id": "DOCK8_MOUSE", "mass": 238978.0, "length": 2100, "protein_name": "Dedicator of cytokinesis protein 8", "gene_name": "Dock8", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 8", "refseq_ac": "NP_083061", "gene_names_uniprotkb": "Dock8", "gene_names_refseq": "1200017A24Rik; 5830472H07Rik; A130095G14Rik; Dock8", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 8", "protein_names_refseq": "dedicator of cytokinesis protein 8", "tax_id": 10090, "disease": "hyper IgE recurrent infection syndrome 2 (Disease Ontology:DOID:0080594); immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (Disease Ontology:DOID:0090110); bacterial infectious disease (Disease Ontology:DOID:104); hepatitis B (Disease Ontology:DOID:2043); atopic dermatitis (Disease Ontology:DOID:3310); viral infectious disease (Disease Ontology:DOID:934); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:76088); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013409); (R-MMU-983231)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "19144319;19898472;21178273;21183079;21969276;22461490;25605945;25713392;28028151;31219806;34428180;35820727;38185418;39627609", "class_list": "", "function": "Characterisation of the DOCK8-deficient mouse revealed T-cell lymphopenia, with increased T-cell turnover and decreased survival., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (PubMed:22461490, PubMed:25713392). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Humoral immunodeficiency due to Dock8 mutation provides evidence that organization of the immunological synapse is critical for signaling the survival of B cell subsets required for long-lasting immunity. Erratum:[Nat Immunol. 2010 Jul;11(7):644. Johnson, Andy [corrected to Johnson, Andy L]], [RefSeq, PubMed]; Mutation of the DOCK8 protein in mice has profound effects on humoral immunity with a failure to sustain the antibody response and failure of germinal center B cell persistence. (Review) Review article, [RefSeq, PubMed]; Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAM7;Q6PIS0;Q7TMQ5;Q8CAP6;Q8K105;Q9DBQ2", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031252 cell leading edge;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0061485 memory T cell proliferation;GO:1903905 positive regulation of establishment of T cell polarity;GO:1990869 cellular response to chemokine;GO:0043547 positive regulation of GTPase activity;GO:2000406 positive regulation of T cell migration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8C147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WC9-1", "uniprot_id": "DGLB_MOUSE", "mass": 73905.0, "length": 669, "protein_name": "Diacylglycerol lipase-beta", "gene_name": "Daglb", "organism": "Mouse", "refseq_name": "diacylglycerol lipase-beta", "refseq_ac": "NP_659164", "gene_names_uniprotkb": "Daglb", "gene_names_refseq": "Daglb; E330036I19Rik", "protein_names_uniprotkb": "Diacylglycerol lipase-beta; 3.1.1.116; 3.1.1.3; DAGL-beta; DAGLbeta; DGL-beta; PUFA-specific triacylglycerol lipase; Sn1-specific diacylglycerol lipase beta", "protein_names_refseq": "DAGL-beta; DAGLbeta; DGL-beta; PUFA-specific triacylglycerol lipase; diacylglycerol lipase-beta; sn1-specific diacylglycerol lipase beta", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:231871); (R-MMU-426048)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14610053;20147530;20159446;21183079;23103940;26779719;27802388;30084848;31105063;31991095;34428180;35715418", "class_list": "", "function": "Authors identify DAGLbeta pathways as a means for attenuating DC inflammatory signaling while sparing critical adaptive immune functions and further expand the utility of targeting lipid pathways for immunomodulation., [RefSeq, PubMed]; DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages., [RefSeq, PubMed]; Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:20147530, PubMed:20159446, PubMed:23103940). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (By similarity). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses (PubMed:23103940, PubMed:26779719). Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages (PubMed:31991095). Plays an important role to support the metabolic and signaling demands of macrophages (PubMed:23103940, PubMed:31991095)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The control of adult neurogenesis in the hippocampus and subventricular zone is compromised in the DAGLalpha(-/-) and/or DAGLbeta(-/-) mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BU39;Q8BU97;Q8BV05", "ec_number_list": "3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.13;3.1.1.6;3.1.1.116;3.1.1.-;2.3.1.51", "go_molecular_function": "GO:0016298 lipase activity;GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0050727 regulation of inflammatory response;GO:0046340 diacylglycerol catabolic process;GO:0007405 neuroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91WC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YW3-1", "uniprot_id": "DNJC3_MOUSE", "mass": 57464.0, "length": 504, "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "Dnajc3", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 3 precursor", "refseq_ac": "NP_032955", "gene_names_uniprotkb": "Dnajc3; P58ipk", "gene_names_refseq": "Dnajc3a; Dnajc3b; Dnajc3; Prkri; mp58; p58IPK; p58", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 3; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 3A; DnaJ (Hsp40) homolog, subfamily C, member 3B; dnaJ homolog subfamily C member 3 precursor; dnaJ homolog subfamily C member 3; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein kinase, interferon inducible double stranded RNA dependent inhibitor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100037258); (R-MMU-381426); (R-MMU-6798695); (R-MMU-8957275); (R-MMU-9833482)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "12446838;19224205;20173027;20184891;22872234;25329545;25428506;30084848;30779550;31219806;34428180;35820727;37329998;37371028;37828378;38279270;8666242", "class_list": "", "function": "Congenital Hyperinsulinism in Humans and Insulin Secretory Dysfunction in Mice Caused by Biallelic DNAJC3 Variants. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (PubMed:25329545). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Neuronal p58[IPK] Protects Retinal Ganglion Cells Independently of Macrophage/Microglia Activation in Ocular Hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Progranulin inhibits fibrosis by interacting with and up-regulating DNAJC3 during mouse skin wound healing., [RefSeq, PubMed]; The stress of unfolded proteins in the ER activates P58(IPK) transcription through an ER stress-response element in its promoter. P58(IPK) interacts with & inhibits PERK, which protects cells during the ER-stress response by reducing protein synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60873", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004860 protein kinase inhibitor activity;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0036494 positive regulation of translation initiation in response to endoplasmic reticulum stress;GO:0070417 cellular response to cold;GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91YW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBB1-1", "uniprot_id": "DUS6_MOUSE", "mass": 42408.0, "length": 381, "protein_name": "Dual specificity protein phosphatase 6", "gene_name": "Dusp6", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 6", "refseq_ac": "NP_080544", "gene_names_uniprotkb": "Dusp6; Mkp3", "gene_names_refseq": "1300019I03Rik; Dusp6; MKP-3; MKP3; PYST1", "protein_names_uniprotkb": "Dual specificity protein phosphatase 6; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 3; MKP-3; Mitogen-activated protein kinase phosphatase 3", "protein_names_refseq": "MAP kinase phosphatase 3; dual specificity protein phosphatase 6; mitogen-activated protein kinase phosphatase 3", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 19 with or without anosmia (Disease Ontology:DOID:0090090); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:67603); (R-MMU-112409); (R-MMU-202670); (R-MMU-5675221)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11960712;12128234;12766772;12776124;21750661;24155322;28405172;32232156;34428180;35820727", "class_list": "", "function": "Cloning and expression analysis during embryogenesis, [RefSeq, PubMed]; Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family (By similarity). Plays an important role in alleviating acute postoperative pain (PubMed:24155322, PubMed:28405172). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (PubMed:24155322). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (PubMed:28405172)., [UniProtKB, UniProtKB, PubMed, PubMed]; During mouse limb bud development, Mkp3, a known MAPK/ERK regulator, is induced in the mesoderm by FGF8 signaling, through the PI3/Akt pathway., [RefSeq, PubMed]; MKP3 mediates the cellular response to FGF8 in the mouse limb., [RefSeq, PubMed]; MPyst1 messenger RNA is found in important signaling centers associated with cell proliferation and patterning in developing mouse embryos, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542I5;Q9D7L4", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;2.7.11.24;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;2.7.11.22;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0060420 regulation of heart growth;GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0051409 response to nitrosative stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DBB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35261-1", "uniprot_id": "E2F3_MOUSE", "mass": 48757.0, "length": 457, "protein_name": "Transcription factor E2F3", "gene_name": "E2f3", "organism": "Mouse", "refseq_name": "transcription factor E2F3 isoform E2f3a", "refseq_ac": "NP_034223", "gene_names_uniprotkb": "E2f3", "gene_names_refseq": "E2F3b; E2f3a; E2f3", "protein_names_uniprotkb": "Transcription factor E2F3; E2F-3", "protein_names_refseq": "transcription factor E2F3 isoform E2f3a; transcription factor E2F3", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:13557); (R-MMU-68911); (R-MMU-69231)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15716352;20176812;21750661;25428506;31219806;34873170;36276637;9149906;9376316", "class_list": "", "function": "Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state. Publication Status: Online-Only, [RefSeq, PubMed]; Matrix stiffness modulates hepatic stellate cell activation into tumor-promoting myofibroblasts via E2F3-dependent signaling and regulates malignant progression. Erratum:[Cell Death Dis. 2022 Jan 28;13(1):91. doi: 10.1038/s41419-022-04528-y. PMID: 35091557] Publication Status: Online-Only, [RefSeq, PubMed]; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (PubMed:20176812)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5T0I6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0070345 negative regulation of fat cell proliferation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35261-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09112-1", "uniprot_id": "DUS8_MOUSE", "mass": 68847.0, "length": 663, "protein_name": "Dual specificity protein phosphatase 8", "gene_name": "Dusp8", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 8", "refseq_ac": "NP_032774", "gene_names_uniprotkb": "Dusp8; Nttp1", "gene_names_refseq": "5530400B01Rik; Dusp8; Nttp1", "protein_names_uniprotkb": "Dual specificity protein phosphatase 8; 3.1.3.16; 3.1.3.48; Neuronal tyrosine threonine phosphatase 1", "protein_names_refseq": "dual specificity protein phosphatase 8; neuronal tyrosine threonine phosphatase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18218); (R-MMU-112409); (R-MMU-5675221)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;32917360;33131190;34197726;37909329;7561881;8733137", "class_list": "", "function": "Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration., [RefSeq, PubMed]; DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha. Publication Status: Online-Only, [RefSeq, PubMed]; Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans., [RefSeq, PubMed]; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation (PubMed:7561881). Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues (Probable)., [UniProtKB, PubMed]; Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;2.7.11.24;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016311 dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O09112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHU4-1", "uniprot_id": "DYHC1_MOUSE", "mass": 532045.0, "length": 4644, "protein_name": "Cytoplasmic dynein 1 heavy chain 1", "gene_name": "Dync1h1", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 1 heavy chain 1", "refseq_ac": "NP_084514", "gene_names_uniprotkb": "Dync1h1; Dhc1; Dnch1; Dnchc1; Dyhc", "gene_names_refseq": "9930018I23Rik; DHC1a; DHC1; DNCL; Dnchc1; Dnec1; Dnecl; Dync1h1; Loa; MAP1C; P22; Swl; mKIAA0325", "protein_names_uniprotkb": "Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic", "protein_names_refseq": "cytoplasmic dynein 1 heavy chain 1; cytoplasmic dynein heavy chain 1; dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic, heavy chain 1; legs at odd angle; sprawling", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); congenital muscular dystrophy (Disease Ontology:DOID:0050557); complex cortical dysplasia with other brain malformations 13 (Disease Ontology:DOID:0061144); autosomal dominant intellectual developmental disorder 13 (Disease Ontology:DOID:0070043); spinal muscular atrophy with lower extremity predominant 1 (Disease Ontology:DOID:0070351); Charcot-Marie-Tooth disease axonal type 2O (Disease Ontology:DOID:0110175); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:13424); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8854518); (R-MMU-9646399); (R-MMU-9648025)", "pathway_count": 21, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;12730604;16496424;18034455;18250455;18299400;19224205;20173027;21183079;21750661;21952136;22956769;23806337;25428506;25428507;25605945;26495903;26740625;28011936;30084848;31219806;31599954;33300544;33649389;34203471;34428180;35820727;35984892;36210013;37507081;37828378;39025270;39627609;39927985", "class_list": "", "function": "Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression., [UniProtKB, UniProtKB]; Patient-specific mutation of Dync1h1 in mice causes brain and behavioral deficits., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QM71", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005938 cell cortex", "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0090235 regulation of metaphase plate congression;GO:1905832 positive regulation of spindle assembly;GO:0008090 retrograde axonal transport;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q9JHU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61168-1", "uniprot_id": "DRD2_MOUSE", "mass": 50930.0, "length": 444, "protein_name": "D(2) dopamine receptor", "gene_name": "Drd2", "organism": "Mouse", "refseq_name": "D(2) dopamine receptor isoform 1", "refseq_ac": "NP_034207", "gene_names_uniprotkb": "Drd2", "gene_names_refseq": "D2R; Drd-2; Drd2", "protein_names_uniprotkb": "D(2) dopamine receptor; Dopamine D2 receptor", "protein_names_refseq": "D(2) dopamine receptor isoform 1; d(2) dopamine receptor; dopamine receptor 2", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); migraine with aura (Disease Ontology:DOID:10024); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); hyperprolactinemia (Disease Ontology:DOID:12700); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug psychosis (Disease Ontology:DOID:1742); anxiety disorder (Disease Ontology:DOID:2030); brain ischemia (Disease Ontology:DOID:2316); alcohol-induced mental disorder (Disease Ontology:DOID:251); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); toxic encephalopathy (Disease Ontology:DOID:3602); primary hyperaldosteronism (Disease Ontology:DOID:446); movement disease (Disease Ontology:DOID:480); schizophrenia (Disease Ontology:DOID:5419); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:13489); (R-MMU-390651)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1991517;21233214;25428506;25865831;30936473", "class_list": "", "function": "Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (PubMed:30936473)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P13953;Q0VGH9", "ec_number_list": "", "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure;GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0021984 adenohypophysis development;GO:0034776 response to histamine", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70169-1", "uniprot_id": "DOC2B_MOUSE", "mass": 45853.0, "length": 412, "protein_name": "Double C2-like domain-containing protein beta", "gene_name": "Doc2b", "organism": "Mouse", "refseq_name": "double C2-like domain-containing protein beta", "refseq_ac": "NP_031899", "gene_names_uniprotkb": "Doc2b", "gene_names_refseq": "Doc2b", "protein_names_uniprotkb": "Double C2-like domain-containing protein beta; Doc2-beta", "protein_names_refseq": "doc2-beta; double C2 protein beta; double C2-like domain-containing protein beta", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:13447)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17548353;18596155;19033398;19410553;20150444;21183079;30369065;33758996;35500882;38242640;8902635", "class_list": "", "function": "Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; DOC2B is a negative regulator of Wnt/beta-catenin signaling pathway in cervical cancer., [RefSeq, PubMed]; Disease-linked mutations in Munc18-1 deplete synaptic Doc2., [RefSeq, PubMed]; Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence., [RefSeq, PubMed]; The protein encoded by this gene is a calcium sensor involved in glucose-stimulated insulin secretion, spontaneous neurotransmitter release, and enhanced SNARE-dependent vesicle fusion. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SS41;Q6NXK3", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0008104 intracellular protein localization;GO:0031340 positive regulation of vesicle fusion;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0048791 calcium ion-regulated exocytosis of neurotransmitter", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P70169-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q148W8-1", "uniprot_id": "STYL2_MOUSE", "mass": 128575.0, "length": 1138, "protein_name": "Serine/threonine/tyrosine-interacting-like protein 2", "gene_name": "Styxl2", "organism": "Mouse", "refseq_name": "serine/threonine/tyrosine-interacting-like protein 2", "refseq_ac": "NP_001028516", "gene_names_uniprotkb": "Styxl2; Dusp27", "gene_names_refseq": "C130085G02Rik; Dusp27; Gm209; Styxl2", "protein_names_uniprotkb": "Serine/threonine/tyrosine-interacting-like protein 2; Inactive dual specificity phosphatase 27", "protein_names_refseq": "dual specificity phosphatase 27 (putative); inactive dual specificity phosphatase 27; serine/threonine/tyrosine-interacting-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:240892)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;35820727;38829202", "class_list": "", "function": "May be required for myofiber maturation., [UniProtKB, UniProtKB]; Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQN8;Q6PCZ9;Q8BX87", "ec_number_list": "", "go_molecular_function": "GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030017 sarcomere", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q148W8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499E4-1", "uniprot_id": "DZI1L_MOUSE", "mass": 87594.0, "length": 774, "protein_name": "Cilium assembly protein DZIP1L", "gene_name": "Dzip1l", "organism": "Mouse", "refseq_name": "cilium assembly protein DZIP1L isoform 2", "refseq_ac": "NP_001298071", "gene_names_uniprotkb": "Dzip1l; wpy", "gene_names_refseq": "2610524A10Rik; Dzip1l", "protein_names_uniprotkb": "Cilium assembly protein DZIP1L; DAZ-interacting zinc finger protein 1-like; Protein warpy", "protein_names_refseq": "DAZ-interacting protein 1-like protein; DAZ-interacting zinc finger protein 1-like; cilium assembly protein DZIP1L isoform 2; cilium assembly protein DZIP1L; protein warpy; zinc finger protein DZIP1L", "tax_id": 10090, "disease": "polycystic kidney disease 5 (Disease Ontology:DOID:0080273); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861)", "pathway": " (mmu:72507)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;28530676;29487109;34428180", "class_list": "", "function": "Dzip1L knockout mice (wpy mutants) display progressive cystic kidney disease and hepatic defects as well as polydactyly, facial clefts, and other embryonic malformations., [RefSeq, PubMed]; Dzip1l promotes ciliary bud formation and is required for the integrity of the transition zone. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in primary cilium formation (PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZI8;Q8C182;Q9CSR1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0021532 neural tube patterning;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q499E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6KAR6-1", "uniprot_id": "EXOC3_MOUSE", "mass": 86455.0, "length": 755, "protein_name": "Exocyst complex component 3", "gene_name": "Exoc3", "organism": "Mouse", "refseq_name": "exocyst complex component 3", "refseq_ac": "NP_796307", "gene_names_uniprotkb": "Exoc3; Sec6l1", "gene_names_refseq": "2810050O03Rik; E430013E20Rik; Exoc3; Sec6l1; Sec6", "protein_names_uniprotkb": "Exocyst complex component 3; Exocyst complex component Sec6", "protein_names_refseq": "SEC6-like 1; exocyst complex component 3; exocyst complex component Sec6", "tax_id": 10090, "disease": "", "pathway": " (mmu:211446); (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15878854;17827149;18480549;21750661;25428506;25605945;30084848;30779550;31219806;34428180;38325858", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice., [RefSeq, PubMed]; The exocyst complex serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0030667 secretory granule membrane;GO:0030496 midbody", "go_biological_process": "GO:0051601 exocyst localization;GO:0015031 protein transport;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0090148 membrane fission", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6KAR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35505-1", "uniprot_id": "FAAA_MOUSE", "mass": 46176.0, "length": 419, "protein_name": "Fumarylacetoacetase", "gene_name": "Fah", "organism": "Mouse", "refseq_name": "fumarylacetoacetase", "refseq_ac": "NP_034306", "gene_names_uniprotkb": "Fah", "gene_names_refseq": "Fah; swst", "protein_names_uniprotkb": "Fumarylacetoacetase; 3.7.1.2; Beta-diketonase; FAA; Fumarylacetoacetate hydrolase", "protein_names_refseq": "FAA; beta-diketonase; fumarylacetoacetase", "tax_id": 10090, "disease": "tyrosinemia type I (Disease Ontology:DOID:0050726); hypertension (Disease Ontology:DOID:10763); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:14085); (R-MMU-8963684)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10508789;11154690;11209059;1524868;1644288;1741389;21183079;21750661;34428180;37453647;37828378;39927985", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY87;Q9QW65", "ec_number_list": "3.7.1.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004334 fumarylacetoacetase activity", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:1902000 homogentisate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P35505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19785-1", "uniprot_id": "ESR1_MOUSE", "mass": 66955.0, "length": 599, "protein_name": "Estrogen receptor", "gene_name": "Esr1", "organism": "Mouse", "refseq_name": "estrogen receptor isoform 1", "refseq_ac": "NP_001289460", "gene_names_uniprotkb": "Esr1; Esr; Estra; Estr; Nr3a1", "gene_names_refseq": "ER-alpha; ERalpha; ERa; ER; ESR; Esr1; Estra; Estr; Nr3a1", "protein_names_uniprotkb": "Estrogen receptor; ER-alpha; ER; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1", "protein_names_refseq": "C-terminally-truncated estrogen receptor alpha product-4; C-terminally-truncated estrogen receptor alpha product-5; C-terminally-truncated estrogen receptor alpha product-6; C-terminally-truncated estrogen receptor alpha product-7; estradiol receptor; estrogen receptor isoform 1; nuclear receptor subfamily 3 group A member 1", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); vitiligo (Disease Ontology:DOID:12306); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); Leydig cell tumor (Disease Ontology:DOID:2696); endometriosis (Disease Ontology:DOID:289); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); infertility (Disease Ontology:DOID:5223); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); sporadic breast cancer (Disease Ontology:DOID:8029); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13982); (R-MMU-1251985); (R-MMU-1257604); (R-MMU-383280); (R-MMU-4090294); (R-MMU-5689896); (R-MMU-6811558); (R-MMU-8866910); (R-MMU-8931987); (R-MMU-8939211); (R-MMU-9009391); (R-MMU-9018519); (R-MMU-9841251)", "pathway_count": 13, "publication_count": 25, "publication_id_list": "10207113;10788465;10840033;10899303;11226831;11704680;15140878;15988012;17595322;20005806;21750661;22031296;24386386;2484714;26585153;31219806;32727504;33067917;34428180;35119658;35119660;7641693;8999954;9192892;9448000", "class_list": "", "function": "Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 0, "mined_o_glycosites": 3, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 25, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJT5;Q9QY51;Q9QY52", "ec_number_list": "", "go_molecular_function": "GO:0031798 type 1 metabotropic glutamate receptor binding;GO:0001093 TFIIB-class transcription factor binding;GO:0034056 estrogen response element binding;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0060523 prostate epithelial cord elongation;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0060745 mammary gland branching involved in pregnancy;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P19785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q148V8-1", "uniprot_id": "FA83H_MOUSE", "mass": 131115.0, "length": 1209, "protein_name": "Protein FAM83H", "gene_name": "Fam83h", "organism": "Mouse", "refseq_name": "protein FAM83H", "refseq_ac": "NP_001161725", "gene_names_uniprotkb": "Fam83h", "gene_names_refseq": "Fam83h; Sack1h", "protein_names_uniprotkb": "Protein FAM83H", "protein_names_refseq": "family with sequence similarity 83, member H; protein FAM83H", "tax_id": 10090, "disease": "amelogenesis imperfecta type 3A (Disease Ontology:DOID:0110055)", "pathway": " (mmu:105732)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17242355;18252228;18630941;19144319;21183079;21750661;23545224;29676651;29709481;31060110;34428180;34887587;36272714;37028581", "class_list": "", "function": "Compared with the control, the Fam83h mutation altered the expression and localization of Fam83h, CK1alpha and beta-catenin in LS8 ameloblasts, inhibited mineralization and down-regulated the expression of mineralization factors., [RefSeq, PubMed]; Effects of Fam83h truncation mutation on enamel developmental defects in male C57/BL6J mice., [RefSeq, PubMed]; Fam83h mutation causes mandible underdevelopment via CK1alpha-mediated Wnt/beta-catenin signaling in male C57/BL6J mice., [RefSeq, PubMed]; Fam83h-/- mice showed no enamel phenotype. Fam83h Tr/Tr (p.Tyr297*) mutation disturbed amelogenesis through a neomorphic mechanism and caused obvious enamel malformations., [RefSeq, PubMed]; Findings demonstrate that over-expression of FAM83H in mice does not produce a phenotype in dentine or enamel., [RefSeq, PubMed]; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration., [UniProtKB, UniProtKB]; These findings shed new light on the association of Fam83h and fluorosis and indicated that high fluoride decreased the expression of Fam83h in morphological and cytological development. This may be one of the reasons for the occurrence of fluorosis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZF6;Q8CI79;Q8R5C2;Q8R5D0", "ec_number_list": "", "go_molecular_function": "GO:1990254 keratin filament binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:0044380 protein localization to cytoskeleton;GO:0031214 biomineral tissue development;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q148V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2PZL6-1", "uniprot_id": "FAT4_MOUSE", "mass": 540316.0, "length": 4981, "protein_name": "Protocadherin Fat 4", "gene_name": "Fat4", "organism": "Mouse", "refseq_name": "protocadherin Fat 4 precursor", "refseq_ac": "NP_899044", "gene_names_uniprotkb": "Fat4; Fatj", "gene_names_refseq": "6030410K14Rik; 9430004M15; Fat4", "protein_names_uniprotkb": "Protocadherin Fat 4; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J", "protein_names_refseq": "FAT tumor suppressor homolog 4; fat-like cadherin protein FAT-J; protocadherin Fat 4 precursor; protocadherin Fat 4", "tax_id": 10090, "disease": "Hennekam syndrome (Disease Ontology:DOID:0060366); Van Maldergem syndrome 2 (Disease Ontology:DOID:0080586); neurodegenerative disease (Disease Ontology:DOID:1289); carcinoma (Disease Ontology:DOID:305); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:329628)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16059920;18604206;19048595;19506035;20485683;21303848;24056717;25605945;30899004;31219806;34418053;34428180;37658376;39927985", "class_list": "", "function": "Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation., [UniProtKB, PubMed, PubMed]; FAT4 overexpression promotes antitumor immunity by regulating the beta-catenin/STT3/PD-L1 axis in cervical cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Fat4 may be a breast tumor suppressor gene, [RefSeq, PubMed]; Results highlight the importance of the Fat4-Dachsous1-Pals1 complex in organizing the apical membrane architecture of neural progenitor cells., [RefSeq, PubMed]; Study shows that Fat4 is an essential gene that has a key role in vertebrate core planar cell polarity; loss of Fat4 disrupts oriented cell divisions and tubule elongation during kidney development, leading to cystic kidney disease., [RefSeq, PubMed]", "predicted_glycosites": 25, "predicted_n_glycosites": 21, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 17, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 18, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 18, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 18, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 5, "glyco_site_count": 46, "binding_glycan_count": 0, "secondary_ac_list": "E9QMR9;Q68FE0;Q8BM82;Q8CD68", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell", "go_biological_process": "GO:0072006 nephron development;GO:0043931 ossification involved in bone maturation;GO:0072137 condensed mesenchymal cell proliferation;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0007009 plasma membrane organization", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q2PZL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EBJ4-1", "uniprot_id": "ERMIN_MOUSE", "mass": 32148.0, "length": 281, "protein_name": "Ermin", "gene_name": "Ermn", "organism": "Mouse", "refseq_name": "ermin", "refseq_ac": "NP_084248", "gene_names_uniprotkb": "Ermn; Kiaa1189", "gene_names_refseq": "A330104H05Rik; Ermn; ermin; mKIAA1189", "protein_names_uniprotkb": "Ermin; JN; Juxtanodin", "protein_names_refseq": "JN; ermin; juxtanodin", "tax_id": 10090, "disease": "", "pathway": " (mmu:77767)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16421295;21183079;25605945;28815590;32848054", "class_list": "", "function": "Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis, [RefSeq, PubMed, UniProtKB]; This study demonstrated that the Juxtanodin expression in rat retinal pigment epithelial cells, and Juxtanodin functional roles in regulating actin cytoskeleton architecture and morphology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVY3;Q5DTZ8;Q8C5L8;Q9CTR3", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0043025 neuronal cell body", "go_biological_process": "GO:0031344 regulation of cell projection organization;GO:0007015 actin filament organization;GO:0008360 regulation of cell shape;GO:0001763 morphogenesis of a branching structure", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5EBJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERL9-1", "uniprot_id": "GCYA1_MOUSE", "mass": 77588.0, "length": 691, "protein_name": "Guanylate cyclase soluble subunit alpha-1", "gene_name": "Gucy1a1", "organism": "Mouse", "refseq_name": "guanylate cyclase soluble subunit alpha-1", "refseq_ac": "NP_068696", "gene_names_uniprotkb": "Gucy1a1; Gucy1a3", "gene_names_refseq": "1200016O07Rik; GCS-alpha-1; GCS-alpha-3; Gucy1a1; Gucy1a3; sGC-alpha1", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit alpha-1; 4.6.1.2; GCS-alpha-1; GCS-alpha-3; Guanylate cyclase soluble subunit alpha-3; Soluble guanylate cyclase large subunit", "protein_names_refseq": "guanylate cyclase 1, soluble, alpha 3; guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; soluble guanylate cyclase large subunit", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); primary open angle glaucoma (Disease Ontology:DOID:1070); Moyamoya disease (Disease Ontology:DOID:13099)", "pathway": " (mmu:60596); (R-MMU-445355)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10984516;21183079;21750661;30899004;34428180;35820727;37343646;38064974", "class_list": "", "function": "Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE[-/-] mice corpus cavernosum microcirculation., [RefSeq, PubMed]; Loss of Gucy1a3 causes poor post-stroke recovery by reducing angiogenesis via the HIF-1alpha/VEGFA signaling pathway in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTG0;Q9DBQ3", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0020037 heme binding;GO:0070026 nitric oxide binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0008074 guanylate cyclase complex, soluble;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0008217 regulation of blood pressure;GO:0060087 relaxation of vascular associated smooth muscle;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0010750 positive regulation of nitric oxide mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9ERL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60759-1", "uniprot_id": "GCDH_MOUSE", "mass": 48606.0, "length": 438, "protein_name": "Glutaryl-CoA dehydrogenase, mitochondrial", "gene_name": "Gcdh", "organism": "Mouse", "refseq_name": "glutaryl-CoA dehydrogenase, mitochondrial", "refseq_ac": "NP_032123", "gene_names_uniprotkb": "Gcdh", "gene_names_refseq": "9030411L18; GCD; Gcdh", "protein_names_uniprotkb": "Glutaryl-CoA dehydrogenase, mitochondrial; 1.3.8.6; GCD", "protein_names_refseq": "glutaryl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "glutaric acidemia I (Disease Ontology:DOID:0111254)", "pathway": " (mmu:270076); (R-MMU-71064)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16452087;21750661;23576753;23806337;24703693;34428180;35639256;37453647;7490088", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor., [UniProtKB]; Disturbance of Mitochondrial Dynamics, Endoplasmic Reticulum-Mitochondria Crosstalk, Redox Homeostasis, and Inflammatory Response in the Brain of Glutaryl-CoA Dehydrogenase-Deficient Mice: Neuroprotective Effects of Bezafibrate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8N6", "ec_number_list": "1.3.8.6", "go_molecular_function": "GO:0004361 glutaryl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046949 fatty-acyl-CoA biosynthetic process;GO:0019395 fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q60759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43027-1", "uniprot_id": "GDF5_MOUSE", "mass": 54895.0, "length": 495, "protein_name": "Growth/differentiation factor 5", "gene_name": "Gdf5", "organism": "Mouse", "refseq_name": "growth/differentiation factor 5 preproprotein", "refseq_ac": "NP_032135", "gene_names_uniprotkb": "Gdf5; Bmp14; Bp; Gdf-5", "gene_names_refseq": "BMP-14; Cdmp-1; Gdf5; bp; brp", "protein_names_uniprotkb": "Growth/differentiation factor 5; BMP-14; Bone morphogenetic protein 14; GDF-5", "protein_names_refseq": "bone morphogenetic protein 14; cartilage-derived morphogenetic protein-1; growth/differentiation factor 5 preproprotein", "tax_id": 10090, "disease": "fibular hypoplasia and complex brachydactyly (Disease Ontology:DOID:0050790); multiple synostoses syndrome (Disease Ontology:DOID:0050794); developmental dysplasia of the hip 1 (Disease Ontology:DOID:0060931); acromesomelic dysplasia, Hunter-Thompson type (Disease Ontology:DOID:0080051); acromesomelic dysplasia, Grebe type (Disease Ontology:DOID:0080052); proximal symphalangism 2 (Disease Ontology:DOID:0080788); multiple synostoses syndrome 1 (Disease Ontology:DOID:0081317); multiple synostoses syndrome 2 (Disease Ontology:DOID:0081318); brachydactyly type A1 (Disease Ontology:DOID:0110964); brachydactyly type A2 (Disease Ontology:DOID:0110965); brachydactyly type C (Disease Ontology:DOID:0110970); brachydactyly type A1C (Disease Ontology:DOID:0110977); Parkinson's disease (Disease Ontology:DOID:14330); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:14563); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14973287;15206957;24076600;35820727;8145850", "class_list": "", "function": "Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity)., [UniProtKB, PubMed, UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ARK2", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:0040014 regulation of multicellular organism growth;GO:0045666 positive regulation of neuron differentiation;GO:0050680 negative regulation of epithelial cell proliferation;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P43027-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FF6-1", "uniprot_id": "GIT1_MOUSE", "mass": 85300.0, "length": 770, "protein_name": "ARF GTPase-activating protein GIT1", "gene_name": "Git1", "organism": "Mouse", "refseq_name": "ARF GTPase-activating protein GIT1 isoform 1", "refseq_ac": "NP_001004144", "gene_names_uniprotkb": "Git1", "gene_names_refseq": "Cat-1; Git1; p95Cat", "protein_names_uniprotkb": "ARF GTPase-activating protein GIT1; ARF GAP GIT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1", "protein_names_refseq": "ARF GAP GIT1; ARF GTPase-activating protein GIT1 isoform 1; ARF GTPase-activating protein GIT1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:216963); (R-MMU-3928664); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424)", "pathway_count": 8, "publication_count": 43, "publication_id_list": "10.1101/2023.09.13.557529;12153727;12695502;14701758;15182672;15592455;15923189;16452087;16959763;17242355;17310244;18034455;19131326;19273721;19383529;20043896;21183079;21499268;21750661;22517741;22645316;23108400;24297929;24586541;25138700;25742295;25792865;26113791;29554125;30084848;31219806;31502302;32460388;32848054;33010377;33300544;34428180;34678516;35066604;35505090;36963288;38899731;40885482", "class_list": "", "function": "Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility., [RefSeq, PubMed]; GIT1 has a role as a scaffold for ERK1/2 activation in focal adhesions, [RefSeq, PubMed]; GIT1 is an untolerized autoantigen involved in immunologic disturbance of spermatogenesis., [RefSeq, PubMed]; GIT1 serves as a scaffold protein to facilitate c-Src-dependent activation of MEK1-ERK1/2 in response to both G protein-coupled receptors and tyrosine kinase-coupled receptors, [RefSeq, PubMed]; GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase. Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (By similarity). May promote cell motility both by regulating focal complex dynamics and by the activation of RAC1 (By similarity). May act as scaffold for MAPK1/3 signal transduction, recruiting MAPK1/3 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (By similarity). Plays a role in brain development and function (PubMed:25792865, PubMed:33010377). Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (PubMed:20043896, PubMed:29554125). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (By similarity). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (PubMed:21499268). Required for successful bone regeneration during fracture healing (PubMed:24586541, PubMed:25138700, PubMed:32460388). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (PubMed:32460388). May play a role in angiogenesis during fracture healing (PubMed:24586541, PubMed:31502302). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (By similarity). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling., [RefSeq, PubMed]; Macrophage GIT1 promotes oligodendrocyte precursor cell differentiation and remyelination after spinal cord injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0044305 calyx of Held;GO:0005739 mitochondrion;GO:0005768 endosome", "go_biological_process": "GO:2000646 positive regulation of receptor catabolic process;GO:0032013 negative regulation of ARF protein signal transduction;GO:0007626 locomotory behavior;GO:0048013 ephrin receptor signaling pathway;GO:0032691 negative regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q68FF6-1", "record_type": "protein" } ]